{"hash":"857778427401118245","title":"Macrophage lipid-mediated inflammation","description":"These proteins cluster around lipid metabolism and inflammatory signaling in macrophages: leukotriene biosynthesis and lipid remodeling point to synthesis and remodeling of lipid mediators; production of IL-8 and IL-1 and foam cell differentiation indicate inflammatory activation; phospholipase activity regulation and lipid storage tie lipid signaling to macrophage function. The combination suggests a theme of macrophage-driven inflammatory responses powered by lipid mediators.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"members":[{"accession":"XP_002698051.2","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]},{"accession":"NP_001095992.1","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]},{"accession":"XP_002685775.1","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]}],"graph":[["XP_002685775.1","XP_002698051.2",0.67],["XP_002685775.1","NP_001095992.1",0.648],["XP_002698051.2","NP_001095992.1",0.704]],"all_go_terms":{"GO:0019370":3,"GO:0044240":3,"GO:0010518":3,"GO:0045740":3,"GO:0032637":3,"GO:0010744":3,"GO:0036148":3,"GO:0036152":3,"GO:0032612":3,"GO:0010884":3,"GO:0042130":3,"GO:0051977":3,"GO:0002227":3,"GO:0036151":3,"GO:0090370":3,"GO:0070374":3,"GO:0036149":3,"GO:0043030":3,"GO:0032308":3,"GO:0002361":3,"GO:0002446":3,"GO:0034374":3,"GO:0050482":3,"GO:0019731":3,"GO:0050830":3,"GO:0006654":3,"GO:0090238":3,"GO:0036150":3},"recipe_readded":[]}