{"hash":"2158550191139186063","title":"RNA and histone methylation regulating transcription","description":"The cluster is dominated by methylation-related GO terms across RNA processing (rRNA methylation, mRNA capping, RNA methylation) and histone/protein methylation (histone H4-R3 methylation, peptidyl-arginine/lysine methylation), with a link to transcriptional control (negative regulation of RNA Pol II). This suggests a cohesive role in methylation-mediated regulation of RNA processing and chromatin state, impacting cell growth and senescence.","confidence":"High","size":14,"edges":45,"triangles":51,"max_degree":10,"top_function":null,"members":[{"accession":"NP_001070364.1","go_terms":["GO:0006479","GO:0030488","GO:1903108","GO:0000462","GO:0031167","GO:0006391"]},{"accession":"NP_001076987.1","go_terms":["GO:0018027","GO:0000183","GO:0018023","GO:0031167","GO:0018013"]},{"accession":"NP_001092397.1","go_terms":["GO:0070901"]},{"accession":"XP_002698734.4","go_terms":["GO:0070131","GO:0042254","GO:0042256","GO:1902626","GO:0006355","GO:0000463","GO:0070475","GO:0002127"]},{"accession":"XP_010816027.2","go_terms":["GO:0016049","GO:0000122","GO:0009236","GO:0018364","GO:0090398","GO:0043985","GO:0031167","GO:0019919","GO:0046690"]},{"accession":"NP_001098439.1","go_terms":["GO:0018027","GO:0000183","GO:0018023","GO:0031167","GO:0018013"]},{"accession":"NP_001300993.1","go_terms":["GO:0009236","GO:0017000","GO:0035690","GO:0006656","GO:0019919","GO:0009102","GO:0030488","GO:0016049","GO:0018012","GO:0006744","GO:0010189","GO:0016126","GO:0043985","GO:0070476","GO:0046690","GO:0002098","GO:0000056","GO:0001300","GO:0090398","GO:0030961","GO:0006370","GO:0009877","GO:0031167","GO:0018364","GO:0036068","GO:0018026","GO:0018027","GO:0036265","GO:1901052","GO:0006596","GO:0000154"]},{"accession":"NP_803471.2","go_terms":["GO:0036265","GO:0031100","GO:0042493","GO:0010243","GO:0006370","GO:0042418"]},{"accession":"XP_059735625.1","go_terms":["GO:0016049","GO:0000122","GO:0009236","GO:0018364","GO:0090398","GO:0043985","GO:0031167","GO:0019919","GO:0046690","GO:0036265","GO:0017000","GO:0006596","GO:0002098","GO:0030488","GO:0000154","GO:0006370","GO:0009877","GO:0018012"]},{"accession":"XP_059735626.1","go_terms":[]},{"accession":"NP_001019723.2","go_terms":["GO:0006351","GO:0016049","GO:0000122","GO:0009236","GO:0090398","GO:0009452","GO:0043985","GO:0070901","GO:0031591","GO:0006364","GO:0034970","GO:0019919","GO:0002939"]},{"accession":"NP_001014922.1","go_terms":["GO:0018027","GO:0000183","GO:0018023","GO:0031167","GO:0018013","GO:0016049","GO:0000122","GO:0009236","GO:0090398","GO:0043985","GO:0019919"]},{"accession":"NP_001179577.1","go_terms":["GO:0036265","GO:0031100","GO:0042493","GO:0010243","GO:0006370","GO:0042418"]},{"accession":"XP_015330111.2","go_terms":["GO:0036265","GO:0031100","GO:0042493","GO:0010243","GO:0006370","GO:0042418"]}],"graph":[["NP_001019723.2","NP_001092397.1",0.757],["NP_001019723.2","NP_001179577.1",0.867],["NP_001019723.2","XP_002698734.4",0.636],["NP_001019723.2","XP_010816027.2",0.809],["NP_001019723.2","XP_015330111.2",0.809],["NP_001019723.2","XP_059735625.1",0.848],["NP_001019723.2","XP_059735626.1",0.89],["XP_002698734.4","NP_001300993.1",0.502],["XP_002698734.4","XP_015330111.2",0.792],["XP_002698734.4","XP_059735626.1",0.67],["XP_002698734.4","NP_001014922.1",0.623],["XP_002698734.4","NP_001070364.1",0.507],["XP_002698734.4","NP_001076987.1",0.604],["XP_002698734.4","NP_001092397.1",0.777],["XP_002698734.4","NP_001098439.1",0.816],["XP_002698734.4","NP_001179577.1",0.631],["NP_001092397.1","NP_001014922.1",0.692],["NP_001092397.1","NP_001070364.1",0.867],["NP_001092397.1","NP_001076987.1",0.71],["NP_001092397.1","NP_001179577.1",0.502],["NP_001092397.1","XP_010816027.2",0.817],["NP_001092397.1","XP_059735625.1",0.699],["NP_001092397.1","XP_059735626.1",0.688],["NP_803471.2","NP_001300993.1",0.538],["NP_803471.2","XP_059735626.1",0.585],["NP_803471.2","NP_001014922.1",0.664],["NP_803471.2","NP_001076987.1",0.617],["NP_803471.2","NP_001179577.1",0.611],["NP_001300993.1","XP_015330111.2",0.712],["NP_001300993.1","NP_001179577.1",0.593],["XP_059735626.1","NP_001179577.1",0.539],["XP_059735626.1","XP_010816027.2",0.691],["XP_059735626.1","XP_059735625.1",0.707],["XP_059735626.1","NP_001070364.1",0.613],["XP_010816027.2","XP_059735625.1",0.697],["XP_010816027.2","NP_001070364.1",0.546],["XP_059735625.1","NP_001070364.1",0.619],["NP_001098439.1","NP_001014922.1",0.637],["NP_001098439.1","NP_001076987.1",0.64],["NP_001179577.1","NP_001070364.1",0.576],["NP_001179577.1","XP_015330111.2",0.789],["NP_001076987.1","NP_001014922.1",0.513],["NP_001076987.1","XP_015330111.2",0.555],["NP_001014922.1","NP_001070364.1",0.535],["NP_001070364.1","XP_015330111.2",0.568]],"all_go_terms":{"GO:0006391":1,"GO:1903108":1,"GO:0031167":7,"GO:0030488":3,"GO:0000462":1,"GO:0006479":1,"GO:0018023":3,"GO:0018027":4,"GO:0018013":3,"GO:0000183":3,"GO:0070901":2,"GO:1902626":1,"GO:0070475":1,"GO:0002127":1,"GO:0042254":1,"GO:0000463":1,"GO:0070131":1,"GO:0042256":1,"GO:0006355":1,"GO:0009236":5,"GO:0016049":5,"GO:0043985":5,"GO:0019919":5,"GO:0090398":5,"GO:0018364":3,"GO:0046690":3,"GO:0000122":4,"GO:0002098":2,"GO:0016126":1,"GO:0000056":1,"GO:0001300":1,"GO:0006596":2,"GO:0017000":2,"GO:0000154":2,"GO:0036068":1,"GO:0006656":1,"GO:0018012":2,"GO:0035690":1,"GO:1901052":1,"GO:0009877":2,"GO:0006744":1,"GO:0009102":1,"GO:0070476":1,"GO:0018026":1,"GO:0006370":5,"GO:0030961":1,"GO:0036265":5,"GO:0010189":1,"GO:0042418":3,"GO:0042493"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