{"hash":"2049325387643925562","title":"Protein quality control via ubiquitin-proteasome system","description":"The cluster\u2019s top GO terms heavily center on ubiquitin-dependent protein degradation (ERAD, proteasomal catabolic processes, aggresome assembly, deubiquitination/deneddylation) and regulation of translation initiation, which together indicate a cohesive proteostasis module for tagging, degrading misfolded proteins, and managing aggregates. Occasional links to nucleotide excision repair appear less central. Overall, this set strongly supports a protein quality control function.","confidence":"High","size":13,"edges":75,"triangles":255,"max_degree":12,"top_function":"DNA replication","members":[{"accession":"XP_059747828.1","go_terms":["GO:0010458","GO:0060542","GO:0070911","GO:0007035","GO:0000086","GO:2000766","GO:0009734","GO:0031146","GO:0042787","GO:0016032","GO:0009873","GO:0007059","GO:0045910","GO:0007275"]},{"accession":"NP_001029386.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"NP_001039958.1","go_terms":["GO:0010458","GO:0060542","GO:0070911","GO:0007035","GO:0000086","GO:2000766","GO:0009734","GO:0031146","GO:0042787","GO:0016032","GO:0009873","GO:0007059","GO:0045910","GO:0007275"]},{"accession":"XP_010800590.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412","GO:0000055"]},{"accession":"NP_001107198.1","go_terms":["GO:0042254","GO:0001172","GO:0006360","GO:0006366","GO:0006386","GO:0006385","GO:0042797"]},{"accession":"NP_001422372.1","go_terms":["GO:0000266","GO:0048140","GO:1990182","GO:0001731","GO:0075522","GO:0016559","GO:0043161","GO:0035871","GO:0070452","GO:0070537","GO:0006281","GO:0000338","GO:0006446","GO:0045471","GO:0010387","GO:0035522","GO:0010950","GO:0014067","GO:0000393","GO:0034286","GO:0051726","GO:1902906","GO:0000398","GO:1903894"]},{"accession":"XP_002690959.3","go_terms":["GO:0051123","GO:1903357","GO:0006413","GO:0070893","GO:0007283","GO:0045893","GO:0006352","GO:0042790","GO:0070898","GO:0006383","GO:0006359"]},{"accession":"XP_059738384.1","go_terms":["GO:0006295","GO:0006294","GO:0006296","GO:0006293","GO:0006298","GO:0036297","GO:0042769","GO:0007004","GO:0000722","GO:0034502","GO:0031571","GO:0006260","GO:0030491","GO:0006284","GO:0010569","GO:0006289","GO:0042276","GO:0000724","GO:0070987","GO:2000001"]},{"accession":"NP_001030389.2","go_terms":["GO:0032436","GO:0001701","GO:0048142","GO:0043248","GO:0007127","GO:0075525","GO:0000122","GO:0008283","GO:0002188","GO:0035914","GO:1902416","GO:0071033","GO:0006283","GO:0030182","GO:0070196","GO:0000338","GO:0075522","GO:0006446","GO:0034260","GO:0070321","GO:0010972","GO:0048863","GO:0001732","GO:0001731","GO:0048140","GO:0036099","GO:0090054","GO:0090052","GO:0000715","GO:0000973","GO:0006511"]},{"accession":"NP_001033636.1","go_terms":["GO:0061738","GO:0031117","GO:0051260","GO:0030420","GO:2001171","GO:0034214","GO:1903862","GO:0032968","GO:0070842","GO:0001824","GO:0006260","GO:0034551","GO:0070682","GO:0033314","GO:0032979","GO:0051013","GO:0046034","GO:1901800","GO:1990171","GO:0016485","GO:0045899","GO:0030968","GO:0006272","GO:0070987","GO:0043335","GO:0070676","GO:0070370","GO:1903007","GO:0090261","GO:0070914","GO:0061641","GO:0061166","GO:1903715","GO:0051301","GO:0006888","GO:0045053","GO:0001319","GO:0035494","GO:0019079","GO:0070414","GO:0097352","GO:0071218","GO:0016562","GO:2000158","GO:0070389","GO:0018279","GO:0006406","GO:0051131","GO:0048219","GO:0030433","GO:1903724","GO:0034599","GO:0090296","GO:0072389","GO:0045041","GO:0016558","GO:0000733","GO:0070407","GO:0070651","GO:0071712","GO:0035617","GO:0090305","GO:0071897"]},{"accession":"NP_001039666.1","go_terms":["GO:0030466","GO:1902985","GO:0006270","GO:0006260"]},{"accession":"NP_001069258.1","go_terms":["GO:0000266","GO:0048140","GO:1990182","GO:0001731","GO:0075522","GO:0016559","GO:0043161","GO:0035871","GO:0070452","GO:0070537","GO:0006281","GO:0000338","GO:0006446","GO:0045471","GO:0010387","GO:0035522","GO:0010950","GO:0014067","GO:0000393","GO:0034286","GO:0051726","GO:1902906","GO:0000398","GO:1903894"]},{"accession":"NP_001092686.1","go_terms":["GO:0035640","GO:1904379","GO:0071218","GO:0035520","GO:0070932","GO:0071108","GO:0048455","GO:0048317","GO:1903644","GO:1903551","GO:0048482","GO:1904669","GO:1903543","GO:0045053","GO:0006886","GO:1904293","GO:0035871","GO:0006511","GO:0045324","GO:0070536"]}],"graph":[["XP_010800590.1","NP_001422372.1",0.746],["XP_010800590.1","XP_002690959.3",0.532],["XP_010800590.1","XP_059747828.1",0.612],["XP_010800590.1","NP_001029386.1",0.729],["XP_010800590.1","NP_001030389.2",0.653],["XP_010800590.1","NP_001033636.1",0.602],["XP_010800590.1","NP_001039958.1",0.69],["XP_010800590.1","NP_001069258.1",0.756],["XP_010800590.1","NP_001092686.1",0.763],["XP_010800590.1","NP_001107198.1",0.754],["NP_001029386.1","NP_001092686.1",0.709],["NP_001029386.1","NP_001069258.1",0.637],["NP_001029386.1","NP_001039958.1",0.733],["NP_001029386.1","NP_001033636.1",0.693],["NP_001029386.1","NP_001039666.1",0.554],["NP_001029386.1","NP_001030389.2",0.566],["NP_001029386.1","NP_001422372.1",0.68],["NP_001029386.1","NP_001107198.1",0.767],["NP_001029386.1","XP_002690959.3",0.705],["NP_001029386.1","XP_059747828.1",0.701],["NP_001039958.1","NP_001030389.2",0.653],["NP_001039958.1","NP_001033636.1",0.635],["NP_001039958.1","NP_001039666.1",0.66],["NP_001039958.1","NP_001069258.1",0.688],["NP_001039958.1","NP_001092686.1",0.621],["NP_001039958.1","NP_001107198.1",0.659],["NP_001039958.1","NP_001422372.1",0.685],["NP_001039958.1","XP_002690959.3",0.67],["NP_001039958.1","XP_059738384.1",0.636],["NP_001039958.1","XP_059747828.1",0.759],["NP_001422372.1","XP_002690959.3",0.704],["NP_001422372.1","XP_059747828.1",0.695],["NP_001422372.1","XP_059738384.1",0.624],["NP_001422372.1","NP_001030389.2",0.702],["NP_001422372.1","NP_001033636.1",0.73],["NP_001422372.1","NP_001039666.1",0.729],["NP_001422372.1","NP_001069258.1",0.676],["NP_001422372.1","NP_001092686.1",0.647],["NP_001422372.1","NP_001107198.1",0.879],["XP_002690959.3","XP_059747828.1",0.631],["XP_002690959.3","XP_059738384.1",0.64],["XP_002690959.3","NP_001030389.2",0.752],["XP_002690959.3","NP_001033636.1",0.784],["XP_002690959.3","NP_001039666.1",0.765],["XP_002690959.3","NP_001069258.1",0.741],["XP_002690959.3","NP_001092686.1",0.595],["XP_002690959.3","NP_001107198.1",0.866],["XP_059738384.1","NP_001107198.1",0.75],["XP_059738384.1","XP_059747828.1",0.842],["XP_059738384.1","NP_001030389.2",0.673],["XP_059738384.1","NP_001033636.1",0.801],["XP_059738384.1","NP_001039666.1",0.697],["XP_059738384.1","NP_001069258.1",0.554],["XP_059738384.1","NP_001092686.1",0.717],["NP_001107198.1","XP_059747828.1",0.638],["NP_001107198.1","NP_001030389.2",0.7],["NP_001107198.1","NP_001033636.1",0.744],["NP_001107198.1","NP_001039666.1",0.688],["NP_001107198.1","NP_001069258.1",0.785],["NP_001107198.1","NP_001092686.1",0.694],["NP_001092686.1","NP_001030389.2",0.646],["NP_001092686.1","NP_001033636.1",0.743],["NP_001092686.1","NP_001039666.1",0.698],["NP_001092686.1","NP_001069258.1",0.657],["NP_001092686.1","XP_059747828.1",0.568],["NP_001030389.2","NP_001033636.1",0.695],["NP_001030389.2","NP_001039666.1",0.679],["NP_001030389.2","NP_001069258.1",0.672],["NP_001030389.2","XP_059747828.1",0.673],["NP_001069258.1","NP_001033636.1",0.718],["NP_001069258.1","NP_001039666.1",0.749],["NP_001069258.1","XP_059747828.1",0.652],["NP_001039666.1","NP_001033636.1",0.71],["NP_001039666.1","XP_059747828.1",0.662],["XP_059747828.1","NP_001033636.1",0.596]],"all_go_terms":{"GO:2000766":2,"GO:0045910":2,"GO:0007059":2,"GO:0060542":2,"GO:0070911":4,"GO:0000086":2,"GO:0031146":2,"GO:0007035":2,"GO:0016032":2,"GO:0010458":2,"GO:0042787":2,"GO:0009734":2,"GO:0009873":2,"GO:0007275":2,"GO:1900186":2,"GO:1903071":2,"GO:0030433":3,"GO:0043433":2,"GO:0034126":2,"GO:1904049":2,"GO:0090204":2,"GO:0000028":2,"GO:0010216":2,"GO:0006357":2,"GO:0032436":3,"GO:0014070":2,"GO:0034140":2,"GO:0030578":2,"GO:0002109":2,"GO:0010637":2,"GO:1904021":2,"GO:0051572":2,"GO:0060334":2,"GO:0035186":2,"GO:0045944":2,"GO:0017085":2,"GO:0035973":2,"GO:0010286":2,"GO:0071276":2,"GO:1901799":2,"GO:0006412":2,"GO:0071816":2,"GO:1902260":2,"GO:0045759":2,"GO:0016579":2,"GO:0006517":2,"GO:1904378":2,"GO:1901896":2,"GO:0006289":3,"GO:0070842":3,"GO:0000753":2,"GO:0097237":2,"GO:1901340":2,"GO:0030474":2,"GO:0021888":2,"GO:0051865":2,"GO:0016925":2,"GO:1903265":2,"GO:0043392":2,"GO:1902283":2,"GO:0086004":2,"GO:1902236":2,"GO:0000423":2,"GO:0033132":2,"GO:0045648":2,"GO:0010636":2,"GO:1905366":2,"GO:1901097":2,"GO:0000055":1,"GO:0006386":1,"GO:0001172":1,"GO:0042254":1,"GO:0006366":1,"GO:0006360":1,"GO:0006385":1,"GO:0042797":1,"GO:0006446":3,"GO:0048140":3,"GO:0035522":2,"GO:0001731":3,"GO:0010950":2,"GO:0035871":3,"GO:0070452":2,"GO:0014067":2,"GO:0000393":2,"GO:0000266":2,"GO:0070537":2,"GO:0000338":3,"GO:1902906":2,"GO:0045471":2,"GO:0010387":2,"GO:0043161":2,"GO:0000398":2,"GO:0016559":2,"GO:1903894":2,"GO:0075522":3,"GO:0051726":2,"GO:0006281":2,"GO:0034286":2,"GO:1990182":2,"GO:0070893":1,"GO:0006383":1,"GO:0051123":1,"GO:0006413":1,"GO:0006359":1,"GO:0070898":1,"GO:0042790":1,"GO:0006352":1,"GO:1903357":1,"GO:0045893":1,"GO:0007283":1,"GO:0034502":1,"GO:0010569":1,"GO:0000722":1,"GO:0006293":1,"GO:0036297":1,"GO:0006296":1,"GO:0006295":1,"GO:0006298":1,"GO:0007004":1,"GO:2000001":1,"GO:0042769":1,"GO:0006294":1,"GO:0006284":1,"GO:0030491":1,"GO:0000724":1,"GO:0042276":1,"GO:0006260":3,"GO:0070987":2,"GO:0031571":1,"GO:0043248":1,"GO:0070321":1,"GO:0048863":1,"GO:0006283":1,"GO:0000122":1,"GO:0002188":1,"GO:0071033":1,"GO:0001732":1,"GO:1902416":1,"GO:0070196":1,"GO:0008283":1,"GO:0030182":1,"GO:0034260":1,"GO:0035914":1,"GO:0048142":1,"GO:0010972":1,"GO:0090054":1,"GO:0001701":1,"GO:0000973":1,"GO:0000715":1,"GO:0090052":1,"GO:0006511":2,"GO:0007127":1,"GO:0075525":1,"GO:0036099":1,"GO:0045053":2,"GO:0045041":1,"GO:0006272":1,"GO:0061166":1,"GO:0031117":1,"GO:0035494":1,"GO:0097352":1,"GO:0070682":1,"GO:0019079":1,"GO:0048219":1,"GO:2000158":1,"GO:0051301":1,"GO:1903007":1,"GO:0070407":1,"GO:0046034":1,"GO:0016485":1,"GO:0070676":1,"GO:0070389":1,"GO:1903862":1,"GO:1903715":1,"GO:0071897":1,"GO:0071218":2,"GO:0090305":1,"GO:0034214":1,"GO:0034551":1,"GO:1990171":1,"GO:2001171":1,"GO:0051013":1,"GO:0070370":1,"GO:0061641":1,"GO:0000733":1,"GO:0072389":1,"GO:0051260":1,"GO:1901800":1,"GO:0016562":1,"GO:0032968":1,"GO:0030968":1,"GO:0001319":1,"GO:0070651":1,"GO:0070414":1,"GO:0061738":1,"GO:1903724":1,"GO:0032979":1,"GO:0070914":1,"GO:0034599":1,"GO:0016558":1,"GO:0035617":1,"GO:0090296":1,"GO:0033314":1,"GO:0045899":1,"GO:0043335":1,"GO:0090261":1,"GO:0001824":1,"GO:0006888":1,"GO:0018279":1,"GO:0006406":1,"GO:0071712":1,"GO:0030420":1,"GO:0051131":1,"GO:0006270":1,"GO:1902985":1,"GO:0030466":1,"GO:0035640":1,"GO:1903644":1,"GO:0048455":1,"GO:0048317":1,"GO:0035520":1,"GO:1904669":1,"GO:1903543":1,"GO:0045324":1,"GO:0070536":1,"GO:1904379":1,"GO:1903551":1,"GO:0070932":1,"GO:1904293":1,"GO:0071108":1,"GO:0048482":1,"GO:0006886":1},"recipe_readded":[]}