{"hash":"1418595625654280473","title":"Pore Formation and Pyroptosis","description":"The cluster is dominated by GO terms for pore formation in membranes, pore complex assembly, and pyroptotic inflammatory response, pointing to a module centered on pore-mediated inflammatory cell death. The inclusion of positive regulation of intrinsic apoptotic signaling and defense against Gram-positive bacteria supports an immune/inflammatory theme. Several terms describe ectodermal development (eye, skin structures) but these appear ancillary; the primary signal across the top terms is pore formation and pyroptosis.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"members":[{"accession":"XP_010799757.1","go_terms":[]},{"accession":"NP_001071558.1","go_terms":["GO:0001949","GO:0051886","GO:0036331","GO:0046931","GO:0007605","GO:0001942","GO:0050718","GO:0070269","GO:2001244","GO:0015768","GO:0050830","GO:0035915","GO:0060113"]},{"accession":"NP_001039625.1","go_terms":["GO:0001949","GO:0051886","GO:0036331","GO:0046931","GO:0007605","GO:0001942","GO:0050718","GO:0070269","GO:2001244","GO:0015768","GO:0050830","GO:0035915","GO:0060113"]},{"accession":"XP_024844521.1","go_terms":["GO:0003289","GO:0043966","GO:0045190","GO:0003290","GO:0051571","GO:0051573","GO:1903758","GO:0051096","GO:0006349","GO:0000414","GO:0043046","GO:0010452","GO:0003149","GO:0006346","GO:1903025","GO:0016446","GO:0043045","GO:0048298"]},{"accession":"XP_059749189.1","go_terms":["GO:0001949","GO:0051886","GO:0036331","GO:0046931","GO:0007605","GO:0001942","GO:0050718","GO:0070269","GO:2001244","GO:0015768","GO:0050830","GO:0035915","GO:0060113"]}],"graph":[["NP_001039625.1","XP_010799757.1",0.749],["NP_001039625.1","XP_059749189.1",0.567],["XP_059749189.1","XP_010799757.1",0.749],["NP_001071558.1","XP_010799757.1",0.749],["XP_010799757.1","XP_024844521.1",0.6]],"all_go_terms":{"GO:0035915":3,"GO:0070269":3,"GO:0007605":3,"GO:0036331":3,"GO:2001244":3,"GO:0046931":3,"GO:0001949":3,"GO:0001942":3,"GO:0050830":3,"GO:0060113":3,"GO:0050718":3,"GO:0015768":3,"GO:0051886":3,"GO:0043966":1,"GO:0003290":1,"GO:1903025":1,"GO:0000414":1,"GO:0051571":1,"GO:0016446":1,"GO:0051096":1,"GO:0003289":1,"GO:1903758":1,"GO:0043046":1,"GO:0043045":1,"GO:0006349":1,"GO:0003149":1,"GO:0048298":1,"GO:0006346":1,"GO:0045190":1,"GO:0010452":1,"GO:0051573":1},"recipe_readded":[]}