{"hash":"328392266691786650","title":"P53-regulated cell cycle and protein stability","description":"Based on the enrichment of GO terms related to p53-mediated signaling, regulation of the cell cycle, protein stabilization, and modulation of ubiquitin-dependent degradation, this cluster appears to center on controlling cell cycle progression under stress and maintaining stability of key proteins, potentially via ubiquitin-proteasome regulation. The translation term is present but secondary to the core theme of cell cycle control and protein stability; the single cobalamin term is likely incidental. Overall, the cluster coherently maps to p53-associated cell cycle regulation and protein stabilization mechanisms.","confidence":"High","size":8,"edges":24,"triangles":36,"max_degree":7,"top_function":null,"members":[{"accession":"XP_005775765.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"XP_005785080.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"XP_005787078.1","go_terms":["GO:0006614","GO:0006616","GO:0006617","GO:0006461","GO:0009236","GO:0051301","GO:0044781"]},{"accession":"XP_005793609.1","go_terms":["GO:0006412"]},{"accession":"XP_005776467.1","go_terms":["GO:0032049","GO:0046838","GO:0030836","GO:0016311","GO:0032361","GO:0009244","GO:0071318","GO:0097171","GO:0031247","GO:0009103"]},{"accession":"XP_005759284.1","go_terms":["GO:0071353","GO:0006412","GO:0000027"]},{"accession":"XP_005787678.1","go_terms":["GO:0017148","GO:0042255","GO:0060702","GO:0046677","GO:0006351","GO:0006353","GO:0006412"]},{"accession":"XP_005770719.1","go_terms":[]}],"graph":[["XP_005775765.1","XP_005776467.1",0.901],["XP_005775765.1","XP_005787078.1",0.929],["XP_005775765.1","XP_005787678.1",0.941],["XP_005775765.1","XP_005793609.1",0.663],["XP_005775765.1","XP_005759284.1",0.869],["XP_005770719.1","XP_005776467.1",0.987],["XP_005770719.1","XP_005785080.1",0.696],["XP_005770719.1","XP_005787678.1",0.99],["XP_005770719.1","XP_005759284.1",0.977],["XP_005759284.1","XP_005776467.1",0.927],["XP_005759284.1","XP_005785080.1",0.811],["XP_005759284.1","XP_005787078.1",0.907],["XP_005759284.1","XP_005787678.1",0.9],["XP_005759284.1","XP_005793609.1",0.9],["XP_005787078.1","XP_005776467.1",0.894],["XP_005787078.1","XP_005785080.1",0.928],["XP_005787078.1","XP_005793609.1",0.937],["XP_005787078.1","XP_005787678.1",0.889],["XP_005793609.1","XP_005776467.1",0.914],["XP_005793609.1","XP_005785080.1",0.764],["XP_005793609.1","XP_005787678.1",0.9],["XP_005776467.1","XP_005785080.1",0.93],["XP_005776467.1","XP_005787678.1",0.943],["XP_005785080.1","XP_005787678.1",0.89]],"all_go_terms":{"GO:1901798":2,"GO:0071158":2,"GO:0071157":2,"GO:0050821":2,"GO:0032986":2,"GO:2000059":2,"GO:1904667":2,"GO:0072717":2,"GO:0006412":5,"GO:0009236":1,"GO:0006614":1,"GO:0006461":1,"GO:0051301":1,"GO:0006616":1,"GO:0044781":1,"GO:0006617":1,"GO:0009103":1,"GO:0030836":1,"GO:0097171":1,"GO:0032361":1,"GO:0009244":1,"GO:0016311":1,"GO:0071318":1,"GO:0032049":1,"GO:0046838":1,"GO:0031247":1,"GO:0000027":1,"GO:0071353":1,"GO:0060702":1,"GO:0017148":1,"GO:0042255":1,"GO:0046677":1,"GO:0006353":1,"GO:0006351":1},"recipe_readded":[]}