{"hash":"2298127855140376985","title":"Acetyl-CoA\u2013driven central carbon metabolism and lipid biosynthesis","description":"These proteins show a coherent signal for central carbon metabolism, with glycolysis and pyruvate decarboxylation feeding into acetyl-CoA, which then fuels the TCA cycle, gluconeogenesis, and lipid biosynthesis (malonyl-CoA and long-chain fatty acids). Amino-acid catabolism of leucine and lysine also contributes acetyl-CoA, supporting energy production and lipid synthesis. Some terms like sodium transport and pyrimidine metabolism are peripheral, but the core theme is acetyl-CoA\u2013centered metabolism.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"members":[{"accession":"XP_005772896.1","go_terms":["GO:0033512","GO:0006814","GO:0006099","GO:2001295","GO:0042759","GO:0006096","GO:0006086","GO:0006552","GO:0006213","GO:0006094"]},{"accession":"XP_005782421.1","go_terms":["GO:0033512","GO:0006814","GO:0006099","GO:2001295","GO:0042759","GO:0006096","GO:0006086","GO:0006552","GO:0006213","GO:0006094"]},{"accession":"XP_005786033.1","go_terms":["GO:0033512","GO:0006814","GO:0006099","GO:2001295","GO:0042759","GO:0006096","GO:0006086","GO:0006552","GO:0006213","GO:0006094","GO:0009249","GO:0019464"]}],"graph":[["XP_005772896.1","XP_005782421.1",0.873],["XP_005772896.1","XP_005786033.1",0.973],["XP_005782421.1","XP_005786033.1",0.978]],"all_go_terms":{"GO:0033512":3,"GO:2001295":3,"GO:0006099":3,"GO:0006814":3,"GO:0006096":3,"GO:0006552":3,"GO:0006086":3,"GO:0006213":3,"GO:0006094":3,"GO:0042759":3,"GO:0019464":1,"GO:0009249":1},"recipe_readded":[]}