{"hash":"175514259414267356","title":"ER Stress Response and Protein Quality Control","description":"The cluster is dominated by terms tied to heat-induced stress responses and protein homeostasis: heat response, unfolded protein response, ER protein folding, and ubiquitin-proteasome\u2013mediated quality control, suggesting a functional group focused on managing misfolded proteins during stress. Some terms like DNA replication and translational frameshifting appear as secondary associations, but the core theme centers on ER-associated folding and degradation pathways under heat stress.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","members":[{"accession":"XP_005789144.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_005777326.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_005756112.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]}],"graph":[["XP_005789144.1","XP_005777326.1",0.891],["XP_005789144.1","XP_005756112.1",0.864],["XP_005777326.1","XP_005756112.1",0.836]],"all_go_terms":{"GO:0009408":3,"GO:0006260":3,"GO:1900035":3,"GO:1901621":3,"GO:0034975":3,"GO:0006452":3,"GO:0051259":3,"GO:0006986":3,"GO:0097428":3,"GO:0071630":3,"GO:0070389":3,"GO:0030433":3,"GO:0006626":3,"GO:0071374":3,"GO:0070843":3,"GO:0090084":3,"GO:0032781":3,"GO:0031204":3,"GO:0036494":3,"GO:0035719":3,"GO:0001707":3,"GO:0046825":3,"GO:0006458":3,"GO:0006469":3,"GO:0045454":3},"recipe_readded":[]}