{"hash":"1684080559714124281","title":"ER Protein Folding and Unfolded Protein Response","description":"The strongest shared functional theme among the top GO terms is protein folding in the endoplasmic reticulum and the cellular response to unfolded proteins, accompanied by a heat-shock/ER-stress context (GO:0034975, GO:0006986, GO:0009408). These indicate a proteostasis/ER stress response cluster, with other terms like translational frameshifting and protein complex oligomerization likely reflecting broader cellular quality-control processes. Overall, the data support a cohesive theme around ER-associated protein folding and stress response rather than a single other pathway.","confidence":"High","size":10,"edges":20,"triangles":10,"max_degree":8,"top_function":null,"members":[{"accession":"XP_005793814.1","go_terms":[]},{"accession":"XP_005772990.1","go_terms":[]},{"accession":"XP_005778219.1","go_terms":[]},{"accession":"XP_005786839.1","go_terms":[]},{"accession":"XP_005760743.1","go_terms":["GO:0000244","GO:0000245","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0071230","GO:0046011","GO:1900365","GO:0071456","GO:1900248","GO:0008069","GO:0061158","GO:0060213","GO:0007310","GO:0032869","GO:0002931","GO:0045451","GO:0050847","GO:0048096","GO:0060212","GO:0035413","GO:0007289","GO:0045314","GO:0001556","GO:1901315","GO:2000623","GO:2000780","GO:0033160"]},{"accession":"XP_005778838.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_005779519.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_005793358.1","go_terms":["GO:0006843","GO:0015709","GO:0030302","GO:0000303","GO:0035352","GO:0034198","GO:0032869","GO:0006828","GO:0015886","GO:0090149","GO:0000002","GO:0030974","GO:0000066","GO:1990616","GO:1990544","GO:0035435","GO:0097274","GO:0031921","GO:0060546","GO:0015866","GO:0048250","GO:1990314","GO:0036233","GO:1990845","GO:0061179","GO:0035349","GO:0008637","GO:0046902","GO:0051881","GO:0043490","GO:0007565","GO:0070542","GO:0090152","GO:1990519","GO:0097421","GO:0015742"]},{"accession":"XP_005774419.1","go_terms":[]},{"accession":"XP_005780211.1","go_terms":[]}],"graph":[["XP_005772990.1","XP_005778219.1",0.736],["XP_005772990.1","XP_005779519.1",0.52],["XP_005772990.1","XP_005786839.1",0.533],["XP_005772990.1","XP_005793358.1",0.812],["XP_005772990.1","XP_005793814.1",0.557],["XP_005793814.1","XP_005774419.1",0.875],["XP_005793814.1","XP_005786839.1",0.513],["XP_005780211.1","XP_005774419.1",0.853],["XP_005780211.1","XP_005778838.1",0.835],["XP_005780211.1","XP_005779519.1",0.583],["XP_005780211.1","XP_005786839.1",0.884],["XP_005786839.1","XP_005774419.1",0.871],["XP_005786839.1","XP_005778219.1",0.827],["XP_005786839.1","XP_005778838.1",0.626],["XP_005786839.1","XP_005793358.1",0.658],["XP_005786839.1","XP_005760743.1",0.917],["XP_005778838.1","XP_005778219.1",0.974],["XP_005793358.1","XP_005760743.1",0.817],["XP_005778219.1","XP_005779519.1",0.862],["XP_005774419.1","XP_005760743.1",0.88]],"all_go_terms":{"GO:0071456":1,"GO:0061158":1,"GO:0046011":1,"GO:0000381":1,"GO:0016556":1,"GO:0008069":1,"GO:0032869":2,"GO:0002931":1,"GO:0035413":1,"GO:0007310":1,"GO:2000623":1,"GO:0000245":1,"GO:0000244":1,"GO:1901315":1,"GO:0050847":1,"GO:0001825":1,"GO:1900365":1,"GO:0031047":1,"GO:0035278":1,"GO:0097010":1,"GO:0007289":1,"GO:2000780":1,"GO:0071230":1,"GO:0034462":1,"GO:0006376":1,"GO:0048255":1,"GO:0001731":1,"GO:0075522":1,"GO:1902625":1,"GO:1900363":1,"GO:0048026":1,"GO:0045292":1,"GO:0001556":1,"GO:0060211":1,"GO:1903586":1,"GO:0060213":1,"GO:1905663":1,"GO:0033160":1,"GO:0006378":1,"GO:0060212":1,"GO:0006406":1,"GO:0045314":1,"GO:0006446":1,"GO:0045451":1,"GO:0002188":1,"GO:1900248":1,"GO:0010610":1,"GO:0048025":1,"GO:0048096":1,"GO:1901407":1,"GO:0000380":1,"GO:0075525":1,"GO:0009408":2,"GO:0006260":2,"GO:1900035":2,"GO:1901621":2,"GO:0034975":2,"GO:0006452":2,"GO:0051259":2,"GO:0006986":2,"GO:0097428":2,"GO:0071630":2,"GO:0070389":2,"GO:0030433":2,"GO:0006626":2,"GO:0071374":2,"GO:0070843":2,"GO:0090084":2,"GO:0032781":2,"GO:0031204":2,"GO:0036494":2,"GO:0035719":2,"GO:0001707":2,"GO:0046825":2,"GO:0006458":2,"GO:0006469":2,"GO:0045454":2,"GO:0046902":1,"GO:0051881":1,"GO:0015742":1,"GO:1990314":1,"GO:1990544":1,"GO:1990616":1,"GO:0015866":1,"GO:0000303":1,"GO:0090152":1,"GO:0034198":1,"GO:0035349":1,"GO:0070542":1,"GO:0006843":1,"GO:0008637":1,"GO:0097274":1,"GO:0030974":1,"GO:0035435":1,"GO:0035352":1,"GO:1990845":1,"GO:0031921":1,"GO:1990519":1,"GO:0000002":1,"GO:0097421":1,"GO:0015709":1,"GO:0030302":1,"GO:0061179":1,"GO:0006828":1,"GO:0015886":1,"GO:0036233":1,"GO:0007565":1,"GO:0043490":1,"GO:0060546":1,"GO:0000066":1,"GO:0090149":1,"GO:0048250":1},"recipe_readded":[]}