{"hash":"1315205777057608554","title":"Amino acid catabolism and vitamin/cofactor biosynthesis","description":"This cluster is dominated by amino acid catabolic processes (valine, alanine, kynurenine) and multiple vitamin/cofactor biosynthetic steps (phylloquinone, menaquinone), along with central carbon metabolism activities (pyruvate biosynthesis, fatty acid beta-oxidation). These terms point to a cohesive metabolic module focused on energy-yielding pathways and cofactor production, rather than signaling or regulatory functions. The Notch signaling term appears less represented and may be a peripheral or outlier signal. Overall, the cluster best represents metabolism centered on amino acid breakdown and vitamin/cofactor biosynthesis.","confidence":"Medium","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"members":[{"accession":"XP_005711074.1","go_terms":["GO:0009116","GO:0019464","GO:0055114"]},{"accession":"XP_005717483.1","go_terms":["GO:0006635","GO:0042372","GO:0017000","GO:0010124","GO:0009234","GO:0006574"]},{"accession":"XP_005717634.1","go_terms":["GO:0072756","GO:0009228","GO:0072747","GO:0046166","GO:0061732","GO:0006098","GO:0006096","GO:0055114","GO:0052865","GO:0005999","GO:0040008","GO:0010510","GO:0006006","GO:0016114","GO:0061034","GO:0006099"]},{"accession":"XP_005718838.1","go_terms":["GO:0019367","GO:0051790","GO:0017000","GO:0051792"]},{"accession":"XP_005710379.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_005711985.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_005713616.1","go_terms":["GO:0006635","GO:0042372","GO:0017000","GO:0010124","GO:0009234","GO:0006574"]},{"accession":"XP_005713935.1","go_terms":["GO:0006635","GO:0042372","GO:0017000","GO:0010124","GO:0009234","GO:0006574"]},{"accession":"XP_005715608.1","go_terms":["GO:0019878","GO:0006090","GO:0006637","GO:0009098","GO:0043640","GO:0070542","GO:0006552","GO:0006814","GO:0001889","GO:0042594","GO:0019336","GO:0046951","GO:0007584","GO:0007005","GO:0006094"]},{"accession":"XP_005716362.1","go_terms":["GO:0006635","GO:0042372","GO:0017000","GO:0010124","GO:0009234","GO:0006574"]},{"accession":"XP_005717438.1","go_terms":["GO:0006545","GO:0006567","GO:0006570","GO:0006569","GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_005718068.1","go_terms":["GO:2001234","GO:0071269","GO:1904831","GO:0051092","GO:0019450","GO:0070814","GO:0019346","GO:0019343","GO:0018272","GO:0044524","GO:0019279","GO:0043123"]},{"accession":"XP_005718094.1","go_terms":["GO:0006635","GO:0042372","GO:0017000","GO:0010124","GO:0009234","GO:0006574"]},{"accession":"XP_005718986.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"YP_007627470.1","go_terms":["GO:0044268","GO:0019552","GO:0042759","GO:2001295","GO:0006633"]},{"accession":"XP_005716159.1","go_terms":["GO:0033353","GO:0006556","GO:0009087","GO:0006730"]},{"accession":"XP_005716285.1","go_terms":["GO:0006642","GO:0032504","GO:0046166","GO:0009658","GO:0061621","GO:0006098","GO:0080022","GO:0019563","GO:0006094"]},{"accession":"YP_007627396.1","go_terms":["GO:0033512","GO:0006814","GO:0006099","GO:2001295","GO:0042759","GO:0006096","GO:0006086","GO:0006552","GO:0006213","GO:0006094"]},{"accession":"XP_005712435.1","go_terms":["GO:0006635","GO:0042372","GO:0017000","GO:0010124","GO:0009234","GO:0006574"]},{"accession":"XP_005718578.1","go_terms":["GO:0006635","GO:0042372","GO:0017000","GO:0010124","GO:0009234","GO:0006574"]},{"accession":"XP_005711220.1","go_terms":["GO:0009113","GO:0006189","GO:0006750"]},{"accession":"XP_005719153.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103"]}],"graph":[["XP_005716159.1","XP_005710379.1",0.924],["XP_005716159.1","XP_005711074.1",0.982],["XP_005716159.1","XP_005711220.1",0.972],["XP_005716159.1","XP_005711985.1",0.985],["XP_005716159.1","XP_005712435.1",0.98],["XP_005716159.1","XP_005713616.1",0.973],["XP_005716159.1","XP_005713935.1",0.987],["XP_005716159.1","XP_005715608.1",0.98],["XP_005716159.1","YP_007627396.1",0.987],["XP_005716159.1","YP_007627470.1",0.962],["XP_005716159.1","XP_005718838.1",0.984],["XP_005716159.1","XP_005718986.1",0.976],["XP_005716159.1","XP_005719153.1",0.935],["XP_005716159.1","XP_005718578.1",0.989],["XP_005716159.1","XP_005717634.1",0.978],["XP_005716159.1","XP_005718068.1",0.954],["XP_005716159.1","XP_005718094.1",0.99],["XP_005716159.1","XP_005717438.1",0.979],["XP_005716159.1","XP_005717483.1",0.972],["XP_005716159.1","XP_005716285.1",0.974],["XP_005716159.1","XP_005716362.1",0.99],["XP_005716362.1","XP_005710379.1",0.969],["XP_005716362.1","XP_005711074.1",0.981],["XP_005716362.1","XP_005711220.1",0.992],["XP_005716362.1","XP_005711985.1",0.987],["XP_005716362.1","XP_005712435.1",0.978],["XP_005716362.1","XP_005713616.1",0.982],["XP_005716362.1","XP_005713935.1",0.977],["XP_005716362.1","XP_005715608.1",0.99],["XP_005716362.1","YP_007627396.1",0.973],["XP_005716362.1","YP_007627470.1",0.982],["XP_005716362.1","XP_005718838.1",0.982],["XP_005716362.1","XP_005718986.1",0.991],["XP_005716362.1","XP_005719153.1",0.968],["XP_005716362.1","XP_005718578.1",0.96],["XP_005716362.1","XP_005717634.1",0.992],["XP_005716362.1","XP_005718068.1",0.986],["XP_005716362.1","XP_005718094.1",0.986],["XP_005716362.1","XP_005717438.1",0.979],["XP_005716362.1","XP_005717483.1",0.982],["XP_005716362.1","XP_005716285.1",0.969],["XP_005718986.1","XP_005710379.1",0.971],["XP_005718986.1","XP_005711074.1",0.972],["XP_005718986.1","XP_005711220.1",0.99],["XP_005718986.1","XP_005711985.1",0.991],["XP_005718986.1","XP_005712435.1",0.986],["XP_005718986.1","XP_005713616.1",0.984],["XP_005718986.1","XP_005713935.1",0.987],["XP_005718986.1","XP_005715608.1",0.983],["XP_005718986.1","XP_005716285.1",0.983],["XP_005718986.1","XP_005717438.1",0.973],["XP_005718986.1","XP_005717483.1",0.982],["XP_005718986.1","XP_005717634.1",0.989],["XP_005718986.1","XP_005718068.1",0.988],["XP_005718986.1","XP_005718094.1",0.988],["XP_005718986.1","XP_005718578.1",0.977],["XP_005718986.1","XP_005718838.1",0.989],["XP_005718986.1","XP_005719153.1",0.983],["XP_005718986.1","YP_007627396.1",0.98],["XP_005718986.1","YP_007627470.1",0.971],["XP_005717438.1","XP_005710379.1",0.979],["XP_005717438.1","XP_005711074.1",0.984],["XP_005717438.1","XP_005711220.1",0.988],["XP_005717438.1","XP_005711985.1",0.987],["XP_005717438.1","XP_005712435.1",0.985],["XP_005717438.1","XP_005713616.1",0.985],["XP_005717438.1","XP_005713935.1",0.99],["XP_005717438.1","XP_005715608.1",0.989],["XP_005717438.1","XP_005716285.1",0.986],["XP_005717438.1","YP_007627396.1",0.981],["XP_005717438.1","YP_007627470.1",0.982],["XP_005717438.1","XP_005718838.1",0.991],["XP_005717438.1","XP_005719153.1",0.985],["XP_005717438.1","XP_005718578.1",0.99],["XP_005717438.1","XP_005717483.1",0.984],["XP_005717438.1","XP_005717634.1",0.987],["XP_005717438.1","XP_005718068.1",0.986],["XP_005717438.1","XP_005718094.1",0.988],["XP_005718068.1","XP_005710379.1",0.889],["XP_005718068.1","XP_005711074.1",0.981],["XP_005718068.1","XP_005711220.1",0.988],["XP_005718068.1","XP_005711985.1",0.966],["XP_005718068.1","XP_005712435.1",0.972],["XP_005718068.1","XP_005713616.1",0.983],["XP_005718068.1","XP_005713935.1",0.986],["XP_005718068.1","XP_005715608.1",0.991],["XP_005718068.1","XP_005716285.1",0.961],["XP_005718068.1","XP_005717483.1",0.977],["XP_005718068.1","XP_005717634.1",0.991],["XP_005718068.1","XP_005718094.1",0.986],["XP_005718068.1","XP_005718578.1",0.986],["XP_005718068.1","XP_005718838.1",0.989],["XP_005718068.1","XP_005719153.1",0.94],["XP_005718068.1","YP_007627396.1",0.99],["XP_005718068.1","YP_007627470.1",0.979],["XP_005711985.1","XP_005710379.1",0.985],["XP_005711985.1","XP_005711074.1",0.99],["XP_005711985.1","XP_005711220.1",0.99],["XP_005711985.1","XP_005712435.1",0.989],["XP_005711985.1","XP_005713616.1",0.992],["XP_005711985.1","XP_005713935.1",0.99],["XP_005711985.1","XP_005715608.1",0.988],["XP_005711985.1","XP_005716285.1",0.953],["XP_005711985.1","XP_005717483.1",0.99],["XP_005711985.1","XP_005717634.1",0.985],["XP_005711985.1","XP_005718094.1",0.987],["XP_005711985.1","XP_005718578.1",0.986],["XP_005711985.1","XP_005718838.1",0.989],["XP_005711985.1","XP_005719153.1",0.984],["XP_005711985.1","YP_007627396.1",0.988],["XP_005711985.1","YP_007627470.1",0.98],["YP_007627396.1","XP_005710379.1",0.988],["YP_007627396.1","XP_005711074.1",0.985],["YP_007627396.1","XP_005711220.1",0.976],["YP_007627396.1","XP_005712435.1",0.99],["YP_007627396.1","XP_005713616.1",0.978],["YP_007627396.1","XP_005713935.1",0.986],["YP_007627396.1","XP_005715608.1",0.986],["YP_007627396.1","XP_005716285.1",0.983],["YP_007627396.1","XP_005717483.1",0.978],["YP_007627396.1","XP_005717634.1",0.981],["YP_007627396.1","XP_005718094.1",0.977],["YP_007627396.1","XP_005718578.1",0.982],["YP_007627396.1","XP_005718838.1",0.967],["YP_007627396.1","XP_005719153.1",0.988],["YP_007627396.1","YP_007627470.1",0.96],["XP_005713935.1","XP_005710379.1",0.982],["XP_005713935.1","XP_005711074.1",0.985],["XP_005713935.1","XP_005711220.1",0.993],["XP_005713935.1","XP_005712435.1",0.984],["XP_005713935.1","XP_005713616.1",0.981],["XP_005713935.1","YP_007627470.1",0.991],["XP_005713935.1","XP_005718838.1",0.981],["XP_005713935.1","XP_005719153.1",0.977],["XP_005713935.1","XP_005718578.1",0.982],["XP_005713935.1","XP_005717634.1",0.988],["XP_005713935.1","XP_005718094.1",0.984],["XP_005713935.1","XP_005717483.1",0.982],["XP_005713935.1","XP_005716285.1",0.984],["XP_005713935.1","XP_005715608.1",0.983],["XP_005716285.1","XP_005710379.1",0.839],["XP_005716285.1","XP_005711074.1",0.991],["XP_005716285.1","XP_005711220.1",0.984],["XP_005716285.1","XP_005712435.1",0.986],["XP_005716285.1","XP_005713616.1",0.985],["XP_005716285.1","XP_005715608.1",0.992],["XP_005716285.1","YP_007627470.1",0.989],["XP_005716285.1","XP_005718838.1",0.98],["XP_005716285.1","XP_005719153.1",0.927],["XP_005716285.1","XP_005718578.1",0.988],["XP_005716285.1","XP_005717634.1",0.989],["XP_005716285.1","XP_005718094.1",0.987],["XP_005716285.1","XP_005717483.1",0.986],["XP_005717483.1","XP_005710379.1",0.984],["XP_005717483.1","XP_005711074.1",0.985],["XP_005717483.1","XP_005711220.1",0.992],["XP_005717483.1","XP_005712435.1",0.981],["XP_005717483.1","XP_005713616.1",0.976],["XP_005717483.1","XP_005715608.1",0.985],["XP_005717483.1","YP_007627470.1",0.985],["XP_005717483.1","XP_005718838.1",0.988],["XP_005717483.1","XP_005719153.1",0.979],["XP_005717483.1","XP_005718578.1",0.976],["XP_005717483.1","XP_005717634.1",0.986],["XP_005717483.1","XP_005718094.1",0.98],["XP_005712435.1","XP_005710379.1",0.98],["XP_005712435.1","XP_005711074.1",0.986],["XP_005712435.1","XP_005711220.1",0.988],["XP_005712435.1","XP_005713616.1",0.977],["XP_005712435.1","XP_005715608.1",0.984],["XP_005712435.1","XP_005717634.1",0.989],["XP_005712435.1","XP_005718094.1",0.985],["XP_005712435.1","XP_005718578.1",0.982],["XP_005712435.1","XP_005718838.1",0.98],["XP_005712435.1","XP_005719153.1",0.975],["XP_005712435.1","YP_007627470.1",0.989],["XP_005713616.1","XP_005710379.1",0.987],["XP_005713616.1","XP_005711074.1",0.978],["XP_005713616.1","XP_005711220.1",0.991],["XP_005713616.1","XP_005715608.1",0.984],["XP_005713616.1","XP_005717634.1",0.984],["XP_005713616.1","XP_005718094.1",0.989],["XP_005713616.1","XP_005718578.1",0.978],["XP_005713616.1","XP_005718838.1",0.988],["XP_005713616.1","XP_005719153.1",0.962],["XP_005713616.1","YP_007627470.1",0.985],["XP_005711220.1","XP_005710379.1",0.988],["XP_005711220.1","XP_005711074.1",0.986],["XP_005711220.1","XP_005715608.1",0.989],["XP_005711220.1","XP_005717634.1",0.981],["XP_005711220.1","XP_005718094.1",0.988],["XP_005711220.1","XP_005718578.1",0.99],["XP_005711220.1","XP_005718838.1",0.989],["XP_005711220.1","XP_005719153.1",0.985],["XP_005711220.1","YP_007627470.1",0.988],["XP_005718838.1","XP_005710379.1",0.981],["XP_005718838.1","XP_005711074.1",0.987],["XP_005718838.1","XP_005715608.1",0.988],["XP_005718838.1","XP_005717634.1",0.984],["XP_005718838.1","XP_005718094.1",0.975],["XP_005718838.1","XP_005718578.1",0.989],["XP_005718838.1","XP_005719153.1",0.986],["XP_005718838.1","YP_007627470.1",0.991],["XP_005711074.1","XP_005710379.1",0.985],["XP_005711074.1","XP_005715608.1",0.99],["XP_005711074.1","XP_005717634.1",0.99],["XP_005711074.1","XP_005718094.1",0.984],["XP_005711074.1","XP_005718578.1",0.98],["XP_005711074.1","XP_005719153.1",0.97],["XP_005711074.1","YP_007627470.1",0.978],["XP_005718094.1","XP_005710379.1",0.983],["XP_005718094.1","XP_005715608.1",0.99],["XP_005718094.1","XP_005717634.1",0.986],["XP_005718094.1","XP_005718578.1",0.985],["XP_005718094.1","XP_005719153.1",0.982],["XP_005718094.1","YP_007627470.1",0.988],["XP_005718578.1","XP_005710379.1",0.982],["XP_005718578.1","XP_005715608.1",0.987],["XP_005718578.1","XP_005717634.1",0.992],["XP_005718578.1","YP_007627470.1",0.991],["XP_005718578.1","XP_005719153.1",0.986],["XP_005710379.1","YP_007627470.1",0.991],["XP_005710379.1","XP_005719153.1",0.97],["XP_005710379.1","XP_005717634.1",0.991],["XP_005710379.1","XP_005715608.1",0.992],["XP_005717634.1","XP_005715608.1",0.967],["XP_005717634.1","XP_005719153.1",0.993],["XP_005717634.1","YP_007627470.1",0.98],["XP_005715608.1","YP_007627470.1",0.988],["XP_005715608.1","XP_005719153.1",0.983],["YP_007627470.1","XP_005719153.1",0.979]],"all_go_terms":{"GO:0009116":1,"GO:0055114":2,"GO:0019464":1,"GO:0006574":7,"GO:0042372":7,"GO:0006635":7,"GO:0010124":7,"GO:0009234":7,"GO:0017000":9,"GO:0006099":2,"GO:0006006":1,"GO:0010510":1,"GO:0006098":2,"GO:0005999":1,"GO:0072756":1,"GO:0016114":1,"GO:0009228":1,"GO:0046166":2,"GO:0006096":2,"GO:0072747":1,"GO:0052865":1,"GO:0040008":1,"GO:0061732":1,"GO:0061034":1,"GO:0051792":1,"GO:0019367":1,"GO:0051790":1,"GO:0042866":4,"GO:0019805":4,"GO:0006564":4,"GO:0006546":4,"GO:0019448":4,"GO:0051384":4,"GO:0046724":4,"GO:0018283":4,"GO:0019265":4,"GO:0043420":4,"GO:0051591":4,"GO:0044571":4,"GO:0034516":4,"GO:0008615":4,"GO:0019442":4,"GO:0007219":5,"GO:0009436":4,"GO:0070903":4,"GO:0042853":5,"GO:0034354":4,"GO:0019700":4,"GO:0097053":5,"GO:0043640":1,"GO:0006814":2,"GO:0019336":1,"GO:0007584":1,"GO:0009098":1,"GO:0019878":2,"GO:0006094":3,"GO:0070542":1,"GO:0006637":1,"GO:0006552":2,"GO:0006090":1,"GO:0001889":1,"GO:0007005":1,"GO:0046951":1,"GO:0042594":1,"GO:0006570":1,"GO:0006569":1,"GO:0006545":1,"GO:0006567":1,"GO:0019346":1,"GO:0051092":1,"GO:0070814":1,"GO:0044524":1,"GO:0019343":1,"GO:1904831":1,"GO:0019450":1,"GO:0018272":1,"GO:0071269":1,"GO:2001234":1,"GO:0043123":1,"GO:0019279":1,"GO:0042759":2,"GO:0044268":1,"GO:0006633":1,"GO:2001295":2,"GO:0019552":1,"GO:0006556":1,"GO:0033353":1,"GO:0006730":1,"GO:0009087":1,"GO:0080022":1,"GO:0019563":1,"GO:0032504":1,"GO:0006642":1,"GO:0009658":1,"GO:0061621":1,"GO:0006086":1,"GO:0006213":1,"GO:0033512":2,"GO:0006750":1,"GO:0006189":1,"GO:0009113":1,"GO:0009246":1,"GO:0046511":1,"GO:0042218":1,"GO:0006686":1,"GO:0009236":1,"GO:0006532":1,"GO:0009245":1,"GO:0006523":1,"GO:0009835":1,"GO:0006107":1,"GO:0055089":1,"GO:0032869":1,"GO:0071555":1,"GO:0019551":1,"GO:0019550":1,"GO:0019441":1,"GO:0034276":1,"GO:0006782":1,"GO:0006533":1,"GO:0006571":1,"GO:0006783":1,"GO:0019518":1,"GO:0015908":1,"GO:0009102":1,"GO:0033585":1,"GO:0046677":1,"GO:0009862":1,"GO:0033362":1,"GO:0009103":1,"GO:0009243":1,"GO:0000105":1,"GO:0006351":1},"recipe_readded":[]}