[{"hash":"276048391847250496","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0072715","count":29},{"id":"GO:0009432","count":29},{"id":"GO:0000393","count":29},{"id":"GO:0014070","count":29},{"id":"GO:1903608","count":29}]},{"hash":"440235047789404684","title":"Developmental signaling and ECM remodeling","description":"The cluster includes terms tied to organismal and spinal cord development (ventral spinal cord development, multicellular organism development), key signaling pathways (BMP signaling, Wnt signaling), ECM remodeling (extracellular matrix disassembly), and transcription regulation during development, plus muscle-related receptor clustering. Some terms (complement activation, tau regulation) are less connected, but the prevailing pattern supports a developmental signaling/ECM remodeling theme.","confidence":"Medium","size":29,"edges":65,"triangles":58,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0022617","count":3},{"id":"GO:0021517","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0007275","count":3}]},{"hash":"724978476956710264","title":"Motor neuron development and migration","description":"The strongest signals in the cluster are GO terms for lateral motor column neuron migration and spinal cord motor neuron cell fate specification, which point to motor neuron development and placement. Additional terms like cell-matrix adhesion support migration, while other terms (retinol metabolism, NFAT signaling) can relate to neuronal differentiation and signaling rather than a single other function. Taken together, the dominant theme is motor neuron development and migration.","confidence":"High","size":29,"edges":386,"triangles":3180,"max_degree":28,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0097477","count":11},{"id":"GO:0007160","count":11},{"id":"GO:0070527","count":11},{"id":"GO:0042572","count":11},{"id":"GO:2000637","count":10}]},{"hash":"13697404778255294","title":"Developmental signaling and cytoskeletal remodeling","description":"The top GO terms converge on signaling pathways (Wnt, GPCR) and regulation of kinase activity, along with actin filament assembly, pointing to signaling-driven development and cytoskeletal remodeling. Terms like oligodendrocyte differentiation and skeletal muscle tissue regeneration support a theme of differentiation and tissue remodeling, while other terms (pain perception, telomeric localization) may reflect broader roles of these proteins in signaling and genome regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":8},{"id":"GO:0098907","count":8},{"id":"GO:0048709","count":7},{"id":"GO:0016055","count":7},{"id":"GO:0071901","count":7}]},{"hash":"2249058250984944323","title":"Developmental regulation and cell cycle control","description":"The dominant terms point to mitotic cell cycle, developmental processes (skin and multicellular organism development), transcription, and signaling regulation (GTPase and kinase activities), suggesting a cluster of proteins coordinating growth, development, and cell-cycle progression rather than a single linear pathway.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000278","count":7},{"id":"GO:0051028","count":7},{"id":"GO:0008284","count":7},{"id":"GO:0043588","count":7},{"id":"GO:0007275","count":7}]},{"hash":"372582777727143881","title":"Melanocyte development and skin morphogenesis","description":"The top GO terms cluster around pigment cell biology and skin-related development: Kit signaling, melanocyte adhesion, outer ear morphogenesis, and vitamin D3 metabolic processes indicate melanocyte differentiation and skin/tissue morphogenesis. Additional terms like angiogenesis and neutrophil clearance suggest broader developmental and immune contexts, but the core signal centers on pigment cell development and skin/craniofacial morphogenesis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000187","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0097350","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0043552","count":4}]},{"hash":"1210089715815553867","title":"Nociception and Thermosensation","description":"The proteins show strong enrichment for pain-related sensing and response (chemical and mechanical nociception, thermoception) and pain response, indicating a module focused on nociception and temperature sensation. Some other terms (ubiquitination, vasopressin secretion) may reflect broader regulatory roles but do not define the core function.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":7},{"id":"GO:0071651","count":7},{"id":"GO:1903759","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0048265","count":7}]},{"hash":"1914267450084924354","title":"Embryonic development and organogenesis","description":"This cluster\u2019s top GO terms center on embryogenesis and organ formation across multiple tissues (eye/retina, primitive streak formation, lung morphogenesis, pancreas development, osteoblasts, cortex interneuron differentiation), indicating a shared role in vertebrate development and organogenesis rather than a single pathway. While eye development terms are prominent, the diversity supports a broad developmental theme.","confidence":"High","size":29,"edges":396,"triangles":3403,"max_degree":28,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0060041","count":14},{"id":"GO:0090009","count":14},{"id":"GO:0043010","count":14},{"id":"GO:0048048","count":14}]},{"hash":"468994147524032107","title":"Embryogenesis and Morphogenesis","description":"The top GO terms point to a developmental/morphogenetic theme across multiple tissues and organs (cartilage formation, placenta/placental development, heart cushion EMT, left-right patterning, endocrine system development, pancreatic cell development). While there are a couple of general cellular processes (peroxisomal protein import, ubiquitination) present, the shared pattern is embryonic development and tissue morphogenesis, suggesting these proteins collectively participate in organogenesis and pattern formation.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0003323","count":6}]},{"hash":"2047860603940133029","title":"Unknown","description":"The top GO terms spread across neural development (axonal fasciculation, synapse assembly, myelination, otolith morphogenesis) and immune/symbiotic processes (neutrophil extravasation, T cell chemotaxis, symbiont entry into host cell) plus general development and DNA integration, with no edges or coherent core function among the proteins. This lack of a single unifying theme makes a specific, representative label unlikely, so Unknown is most appropriate.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000391","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0032474","count":2}]},{"hash":"705490058819248110","title":"Regulation of translation initiation and reinitiation","description":"The top GO terms cluster tightly around how translation starts and restarts\u2014formation of the preinitiation complex, initiation regulation, reinitiation, and even IRES-dependent viral translation\u2014pointing to a core theme of translational control. Regulatory ncRNA-mediated silencing can influence translation, supporting the overall focus on initiation and reinitiation control. Some terms about growth or development appear ancillary rather than defining the cluster.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0075525","count":3},{"id":"GO:0002188","count":3}]},{"hash":"2137766970382857237","title":"Bone and Nervous System Development","description":"The cluster is enriched for terms related to skeletal/bone maturation and skeletal system development, along with nervous system development and synapse assembly, suggesting a developmental program for bone and neural tissues. Cell adhesion terms further support tissue morphogenesis, linking formation of bone and neural connections. Immune-related terms appear less central to the core theme.","confidence":"High","size":29,"edges":18,"triangles":1,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007156","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0007399","count":6}]},{"hash":"2159526854931865175","title":"Ion Transport and Nutrient Stress Response","description":"These proteins are best characterized by membrane transport functions, with GO terms for sodium and potassium ion transmembrane transport and various nutrient transports (dehydroascorbic acid, vitamins, fructose, lactose-related processes) and stress responses (glucose/osmotic stress). A few terms (e.g., regulation of axon extension) are less cohesive with transport, but overall the cluster centers on ion/nutrient transport and nutrient stress responsiveness.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":3},{"id":"GO:0030516","count":3},{"id":"GO:0042149","count":2},{"id":"GO:0042891","count":2}]},{"hash":"2005189162499999714","title":"Unknown","description":"The Top Terms span nucleic acid metabolism and genome maintenance (DNA integration, miRNA/histone mRNA catabolic processes, DNA damage checkpoint signaling), signaling regulation, metabolism, ion transport, and neuronal development, with no clear single theme or connected module (no edges). Therefore there is no cohesive function to label except Unknown.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031953","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0010587","count":2},{"id":"GO:0071044","count":2}]},{"hash":"566486242352236171","title":"Epigenetic Chromatin Regulation","description":"The GO terms center on nucleosome assembly and histone modifications (H3-K27 methylation/acetylation) and DNA demethylation regulation, pointing to epigenetic chromatin remodeling as the dominant theme. A minority of terms relate to development and hormone signaling, but do not outweigh the epigenetic signal.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901536","count":3},{"id":"GO:0045869","count":3},{"id":"GO:0060669","count":3},{"id":"GO:0070562","count":3},{"id":"GO:0006334","count":2}]},{"hash":"659085530055961343","title":"Cardiac development and ECM remodeling","description":"These proteins are enriched for heart development and cardiac muscle differentiation terms, with concurrent themes in extracellular matrix organization (collagen fibril organization) and angiogenesis, plus proteolysis suggesting ECM remodeling. The presence of cell division and centrosome-related terms may reflect proliferative states common in development. Overall, the cluster appears to center on cardiovascular development and ECM remodeling processes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0003257","count":2},{"id":"GO:2000727","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1670696030692392438","title":"Neuronal differentiation and lineage specification","description":"Proteins in this cluster are enriched for neural development terms, including cerebellar Purkinje cell differentiation, spinal cord motor neuron fate specification, and midbrain dopaminergic neuron differentiation, suggesting a common theme of neuronal lineage specification and maturation. While there are a few outliers (e.g., sulfur oxidation, B cell signaling regulation), the prominent terms point to neural differentiation programs and related signaling pathways such as calcineurin-NFAT.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021702","count":2},{"id":"GO:2000637","count":1},{"id":"GO:0050859","count":1},{"id":"GO:0021520","count":1},{"id":"GO:0019417","count":1}]},{"hash":"2073229056155469854","title":"Embryonic Development and Tissue Differentiation","description":"This cluster is enriched in GO terms tied to developmental processes across multiple tissues (cartilage morphogenesis, endocrine system development, trophoblast giant cell differentiation, placental development, EMT in endocardial cushion formation). While there are also terms for RNA processing and ribosome export, the recurring theme is embryonic development and tissue differentiation, suggesting these proteins participate in differentiation programs rather than a single metabolic pathway.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":3},{"id":"GO:0032298","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0060536","count":3},{"id":"GO:1903026","count":3}]},{"hash":"973887631229131912","title":"Neuroimmune Signaling and Development","description":"This cluster shows strong signals for immune responses (lipopolysaccharide response, GM-CSF stimulus, T cell receptor signaling, IL-2 production, interferon-beta production) alongside neural processes (axonogenesis, corpus callosum development, visual learning, pain-related behavior). The overlap suggests neuroimmune signaling or interactions between immune pathways and neural development/function, so the name captures both domains without overfitting to a single function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0097011","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0032743","count":3},{"id":"GO:0008542","count":3}]},{"hash":"2289285689882860302","title":"Nucleic acid processing and DNA repair","description":"The cluster\u2019s top GO terms cluster around nucleic acid metabolism and genome maintenance, including RNA processing (RNA phosphodiester bond hydrolysis; regulation of mRNA stability), base-excision repair, and DNA recombination. While there are some unrelated terms (cAMP signaling, redox/homeostasis, skin development), the strongest signals point to nucleic acid processing and repair as the core theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0090502","count":5},{"id":"GO:0006310","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0014912","count":3}]},{"hash":"142347649932919451","title":"Cell Cycle and Cytoskeleton Regulation","description":"This cluster is dominated by GO terms linked to the mitotic cell cycle and cytoskeleton regulation, including mitotic cell cycle, cell division, negative regulation of Arp2/3-mediated actin nucleation, and positive regulation of GTPase activity. These collectively point to coordination of cell proliferation and actin dynamics. The remaining terms are more peripheral (gravitropism, dense core granule maturation, proteoglycan biosynthesis, plasminogen activation, lipid metabolism) and do not define a single unified function, so the core theme is cell-cycle and cytoskeleton control with moderate support from other processes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0034316","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0009958","count":2}]},{"hash":"849675643255200701","title":"Developmental transcription and differentiation","description":"These proteins show enrichment for transcriptional regulation and broad developmental processes (skeletal, neural, lens, gonadal development), plus differentiation-associated trafficking (ER\u2013Golgi transport). The cohesive theme is gene regulation during development, with various lineage-specific differentiation terms supporting a developmental program. Confidence: High","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0008584","count":3}]},{"hash":"1228128698769966058","title":"Eye Development and Visual Perception with Pigment Transport","description":"The Top Terms show a clear tilt toward the visual system (retina vasculature development in camera-type eye; visual perception; endosome to melanosome transport), suggesting a theme around eye development and pigment-related trafficking. Junction assembly terms (paranodal/smooth septate) and Notch-related regulation also appear, pointing to broader developmental signaling contexts that accompany ocular tissue organization. Overall, the cluster aligns with eye-specific functions and pigment transport, with some signaling-level terms as supplementary context.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901223","count":3},{"id":"GO:0045071","count":2},{"id":"GO:0061298","count":2},{"id":"GO:0090528","count":2},{"id":"GO:0030913","count":2}]},{"hash":"1809456940484579294","title":"Neural Sensory Signaling and Dopaminergic Pathways","description":"This cluster shows a clear emphasis on neural processing and neurotransmission: pain and visual perception, visual learning, dopaminergic synaptic transmission, and behavioral responses to cocaine. The inclusion of ERK cascade regulation and prostaglandin stimuli points to signaling dynamics in neurons, while temperature- and metabolism-related terms may reflect neuronal regulation of energy balance. A few terms like heart development are less directly connected but can appear in broader developmental signaling contexts. Overall, the dominant theme is neural sensory processing and dopaminergic signaling.","confidence":"Medium","size":28,"edges":167,"triangles":286,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":22},{"id":"GO:0007507","count":19},{"id":"GO:0007601","count":18},{"id":"GO:0070374","count":18},{"id":"GO:0071502","count":18}]},{"hash":"1786964884790160877","title":"Dopaminergic signaling and neural plasticity","description":"The top GO terms cluster around dopamine-related neural signaling and plasticity: dopaminergic synaptic transmission, behavioral response to cocaine, sensory perception (sight and pain), and visual learning. The presence of ERK1/2 cascade regulation and positive regulation of GTPase activity supports intracellular signaling pathways driving synaptic strength and plasticity, fitting a coherent theme of reward-related neural signaling and perception. A few terms (e.g., heart development) are less directly tied but may reflect shared developmental or pleiotropic genes, not changing the overall neural signaling-focused interpretation.","confidence":"High","size":28,"edges":365,"triangles":2958,"max_degree":27,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":25},{"id":"GO:0043547","count":24},{"id":"GO:0008542","count":22},{"id":"GO:0007601","count":22},{"id":"GO:0048148","count":22}]},{"hash":"2044231314319651160","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":15,"triangles":0,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070208","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0002291","count":4},{"id":"GO:0030212","count":4},{"id":"GO:0000480","count":4}]},{"hash":"1424482941960581144","title":"Endothelial activation and angiogenesis with inflammation","description":"The top terms point to endothelial barrier regulation, angiogenesis, and coagulation (plasminogen activation, fibrinolysis) alongside innate immune activity (complement lectin pathway, LPS response, IL-1\u03b2 production). This suggests a coherent cluster of vascular endothelial responses intertwined with inflammatory and coagulation pathways, indicating remodeling and immune activation rather than a single isolated function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":14},{"id":"GO:0045944","count":11},{"id":"GO:0031639","count":11},{"id":"GO:0045766","count":11},{"id":"GO:0001867","count":11}]},{"hash":"1859811221908765104","title":"Neurotransmission and Neural Development","description":"This cluster is dominated by GO terms related to neurotransmitter handling (serotonin uptake, glycine secretion, dopamine catabolic process) and neural development (thalamus development, adenohypophysis development, perineurial glial growth). Although proline transport appears, the overall pattern points to proteins involved in neuronal signaling and brain development, suggesting roles in synaptic function and neural maturation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":7},{"id":"GO:0014064","count":7},{"id":"GO:1905847","count":7},{"id":"GO:1903346","count":7},{"id":"GO:0021984","count":7}]},{"hash":"1292518136891943094","title":"Axon guidance and synaptic vesicle regulation","description":"This cluster is dominated by neuronal development and vesicle trafficking terms (axon guidance, Roundabout signaling, negative regulation of/ regulation of synaptic vesicle exocytosis), with supporting signals for cell migration and morphogenesis (epithelial morphogenesis, mast cell chemotaxis, sprouting angiogenesis). The core theme appears to be neural development and vesicle exocytosis control, with some related migratory processes.","confidence":"Medium","size":28,"edges":97,"triangles":34,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010796","count":6},{"id":"GO:0090307","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0003382","count":5}]},{"hash":"1879506879948454822","title":"Neuronal development and actin remodeling","description":"The cluster\u2019s terms cluster around nervous system development, neuron migration, and cytoskeletal dynamics (microspike assembly and Rho protein signaling), indicating proteins involved in neural development and actin cytoskeleton remodeling. The presence of pathways regulating neuron migration and sympathetic nervous system development, along with actin-related processes, supports a cohesive theme of neural development coordinated by cytoskeletal signaling. While there are scattered terms touching on signaling cascades and endocytosis, the dominant pattern points to neuronal development via actin remodeling and Rho-mediated cytoskeletal control.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0048549","count":2},{"id":"GO:2001240","count":1},{"id":"GO:0001764","count":1}]},{"hash":"2079671904405807533","title":"Nuclear RNA processing and chromatin regulation","description":"The cluster\u2019s top GO terms center on nuclear processes: chromatin-related functions (pericentric heterochromatin formation), RNA processing (spliceosomal disassembly, ribosomal large subunit biogenesis), and regulatory RNA pathways (ncRNA-mediated gene silencing). These suggest roles in transcriptional and post-transcriptional control within the nucleus, with a few terms touching on broader developmental and cellular growth processes. Overall, the common theme is nuclear gene expression regulation and RNA processing rather than cytoplasmic signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034644","count":2},{"id":"GO:0030702","count":2},{"id":"GO:2000270","count":2},{"id":"GO:0060065","count":2},{"id":"GO:2001015","count":2}]},{"hash":"595325801838153218","title":"Cell Signaling and Neural Development","description":"This cluster centers on signaling pathways: peptide hormone response, cAMP, insulin receptor signaling, PI3K/AKT, and GPCR signaling, with additional links to brain development and heart rate regulation. It also includes innate immune signaling and apoptosis, suggesting a broad set of proteins involved in diverse signal transduction and developmental processes rather than a single pathway. The lack of direct interactions (no edges) implies shared functional annotations rather than a tightly connected module. Overall, the common theme is cellular signaling with neurodevelopmental and cardiovascular associations, plus immune responses.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0071375","count":3},{"id":"GO:0071320","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0045087","count":3}]},{"hash":"392686113500148722","title":"Neuronal GPCR Signaling and Ca2+/cAMP","description":"Reasoning: The top GO terms cluster around GPCR-mediated signaling (dopamine, adrenergic, histamine receptors) and downstream second-messenger pathways (activation of adenylate cyclase, release of Ca2+ into the cytosol). Terms like response to morphine and MAPK-activating adrenergic receptor signaling point to neuronal signaling networks, while terms for saliva secretion and visual learning hint at autonomic and central nervous system functions. Taken together, the proteins seem to participate broadly in GPCR-driven signaling with calcium and cAMP as key messengers, rather than a single tightly defined process.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0032675","count":2},{"id":"GO:0046541","count":2},{"id":"GO:0008542","count":2}]},{"hash":"544952993929104299","title":"Cholesterol and steroid metabolism in angiogenesis","description":"This cluster is dominated by GO terms related to cholesterol handling and steroid hormone processes (cholesterol import, cholesterol esterification, glucocorticoid and progesterone biosynthesis, PPAR signaling) along with vascular development activities (heart morphogenesis, endothelial tube lumen extension, regulation of sprouting angiogenesis). Together these suggest a theme where lipid/steroid metabolism intersects with angiogenesis and cardiovascular development; an outlier term about floral organ identity appears as noise but does not negate the overall pattern.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032418","count":2},{"id":"GO:0003007","count":2},{"id":"GO:0008211","count":2},{"id":"GO:0097498","count":2},{"id":"GO:0010873","count":2}]},{"hash":"1398595929894648385","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"The top GO terms cluster around ubiquitin-mediated protein catabolism, ERAD, and autoubiquitination, plus immune signaling pathways like TNF-mediated signaling and NF-\u03baB activation, pointing to a functional theme of ubiquitin-proteasome\u2013dependent turnover linked to immune signaling. Some terms (dosage compensation, V(D)J recombination) are related to broader chromatin regulation or immunological processes and could reflect pleiotropy, but overall the dominant thread is ubiquitination-driven degradation and NF-\u03baB\u2013related signaling.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0030433","count":8},{"id":"GO:0051865","count":8},{"id":"GO:1901253","count":7},{"id":"GO:0033209","count":7}]},{"hash":"1653872144822312113","title":"Thymus development and T cell tolerance","description":"The cluster shows strong enrichment for thymus morphogenesis, regulation of thymocyte migration, and both central and peripheral T cell tolerance, pointing to a shared role in thymic T cell development and selection. Some terms relate to nucleosome assembly and histone modifications, which may reflect broader epigenetic regulation, but the core signal centers on thymus biology and immune tolerance.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002509","count":3},{"id":"GO:0032602","count":3},{"id":"GO:0002458","count":3},{"id":"GO:2000410","count":3},{"id":"GO:0097536","count":3}]},{"hash":"1236417942467525758","title":"Cross-tissue Development and Differentiation","description":"The Top Terms indicate involvement in developmental differentiation across multiple tissues (skeletal muscle, tongue, nervous system, oligodendrocytes) along with relevant signaling pathways (growth hormone receptor signaling, B cell receptor signaling) and regulatory processes (negative regulation of proliferation, mRNA processing). This points to a broad theme of developmental differentiation and signaling rather than a single-tissue function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0008285","count":2}]},{"hash":"1942647263823725674","title":"Rho-Dependent Synaptic Spine Remodeling","description":"This cluster is dominated by terms tied to Rho GTPase signaling, actin cytoskeleton organization, and dendritic spine morphogenesis, all key components of synaptic structural plasticity and remodeling. Additional terms like exocytosis and long-term synaptic depression further support a theme of activity-dependent synapse modulation, so a label centered on Rho-driven spine remodeling and synaptic plasticity fits well. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":7},{"id":"GO:2000009","count":6},{"id":"GO:0007266","count":6},{"id":"GO:0090630","count":6},{"id":"GO:0030036","count":6}]},{"hash":"2271565102923940198","title":"Plant RNA Processing and Splicing","description":"The cluster\u2019s top terms are dominated by RNA processing activities, including mRNA splicing via spliceosome, chloroplast mRNA processing, and polycistronic mRNA processing, pointing to RNA maturation in plant cells. Some other terms appear peripheral or less cohesive, but the central theme aligns with plant RNA metabolism.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0010239","count":1},{"id":"GO:0080163","count":1},{"id":"GO:0043086","count":1}]},{"hash":"421793959374861360","title":"Cellular stress response and apoptosis","description":"The top GO terms indicate a strong emphasis on stress-related cellular responses: response to hydrogen peroxide, hypoxia, and xenobiotic stimuli, as well as cellular response to cAMP, which often mediates stress signaling. The presence of apoptotic process and regulation of mRNA stability suggests coupling between stress sensing and control of cell fate and gene expression. A subset of terms related to biotin and antibiotic biosynthesis hints at metabolic context but does not override the core stress/apoptosis theme. Overall, the cluster seems to group proteins involved in sensing and responding to cellular stress and toggling growth or death decisions.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0043488","count":3},{"id":"GO:0070301","count":3},{"id":"GO:0071320","count":3},{"id":"GO:0042493","count":3}]},{"hash":"1317806440358116339","title":"Translation Initiation and IRES-Driven Regulation","description":"The cluster is dominated by GO terms linked to translation initiation and its regulation, including IRES-dependent viral initiation, initiation complex formation, translation reinitiation, and eIF4F complex assembly. While a few terms touch on RNA processing and transcription, the strongest signal is the machinery and control of initiating translation, suggesting a cohesive theme around translation initiation.","confidence":"High","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0075522","count":5},{"id":"GO:0006446","count":5},{"id":"GO:0075525","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0002188","count":4}]},{"hash":"2051678523818445476","title":"Protein turnover and metabolic regulation","description":"The top terms point to ubiquitin-dependent degradation via the multivesicular body sorting pathway, protein assembly, and energy-related processes (energy homeostasis and circadian entrainment by photoperiod). Together these suggest a group of proteins involved in regulating protein stability and cellular energy state, with membrane signaling potentially linked to energetic status. The viral process term may reflect host-virus interactions rather than a core cluster function. ","confidence":"Medium","size":27,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060081","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0043162","count":2},{"id":"GO:0051262","count":2},{"id":"GO:1901998","count":1}]},{"hash":"588407260574717855","title":"Ubiquitin-regulated protein quality control","description":"The cluster is dominated by GO terms for ubiquitin-related processes (deubiquitination, sumoylation) and ERAD-associated quality control, suggesting a core theme around protein modification and degradation pathways. While some terms point to development and immune functions, the strongest common thread appears to be ubiquitin-mediated regulation and protein quality control.","confidence":"Medium","size":27,"edges":313,"triangles":2339,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":9},{"id":"GO:0016925","count":8},{"id":"GO:1904378","count":7},{"id":"GO:0045648","count":7},{"id":"GO:0051603","count":7}]},{"hash":"1691366474280373208","title":"Ribosome Biogenesis and Chromosome Segregation","description":"The top GO terms indicate strong enrichment for ribosome biogenesis (ribosomal large subunit biogenesis; ribosome biogenesis) along with cell cycle\u2013related processes (mitotic spindle assembly; meiotic sister chromatid cohesion), pointing to a cluster of proteins involved in ribosome production plus nuclear/chromosome maintenance. Some terms (histone modification, mRNA transport) also align with chromatin regulation and RNA handling in the nucleus, though a couple terms (retina development, gamma radiation response) may be secondary or annotation noise. Overall, the dominant theme is ribosome assembly coupled with chromosome segregation/chromatin dynamics. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0071480","count":3},{"id":"GO:0090005","count":2},{"id":"GO:0051754","count":2},{"id":"GO:0070262","count":2}]},{"hash":"307777113409803619","title":"Mitosis and cell division","description":"This cluster is dominated by GO terms tied to mitosis and the cell cycle, including mitotic spindle assembly, sister chromatid segregation, and mitotic DNA replication, along with broader cell division and growth-related processes. The combination suggests proteins functioning in mitotic progression and general cell-cycle control, with supporting ubiquitin-mediated proteolysis and growth signaling. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000060","count":4},{"id":"GO:0031081","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0000070","count":4},{"id":"GO:0051301","count":4}]},{"hash":"481794741069710284","title":"Broad developmental organogenesis and neural signaling","description":"Many top GO terms point to development of multiple organs (midgut, heart, olfactory pit, nose, Harderian gland) and to neural-related functions (righting reflex), as well as signaling pathways involved in development (retinoic acid response) and neuronal metabolism (GABA shunt). The common theme is broad developmental processes across organs with a neural/sensory emphasis, so a label like multi-organ development with neural signaling fits well.","confidence":"Medium","size":27,"edges":110,"triangles":189,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0007494","count":6},{"id":"GO:0060166","count":6},{"id":"GO:0009447","count":6},{"id":"GO:0003007","count":6},{"id":"GO:0019544","count":6}]},{"hash":"1038623527431828180","title":"Ubiquitin-mediated proteostasis and stress signaling","description":"This cluster is enriched for ubiquitin-dependent protein catabolic processes and ERAD, plus TORC1 signaling regulation and innate immune/apoptotic responses, suggesting a cohesive theme of proteostasis under stress and its signaling pathways.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0035372","count":3},{"id":"GO:0006915","count":3},{"id":"GO:1903343","count":3}]},{"hash":"383990682021412473","title":"Unknown","description":"The top GO terms cover a mix of processes: cell polarity regulation, apical/budding growth, septation signaling, phosphorylation regulation, and several development terms (diencephalon, skeletal system, ovarian follicle). There is no single, coherent biological function that ties all 27 proteins together, and the very small counts (mostly single terms) support a diverse or incidental set of annotations rather than a shared pathway. Therefore, a unique, representative label is not evident.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000100","count":1},{"id":"GO:0007118","count":1},{"id":"GO:0000920","count":1},{"id":"GO:0031031","count":1},{"id":"GO:0042327","count":1}]},{"hash":"830408295885928149","title":"RNA processing and translation regulation","description":"The cluster is dominated by terms related to RNA maturation and post-transcriptional control, including mRNA polyadenylation, splicing, regulation of mRNA stability, and regulation of translational initiation, as well as components involved in translation initiation complex assembly and miRNA-mediated silencing. The convergence of these processes suggests proteins that coordinate RNA processing and control of translation, rather than a single pathway. ","confidence":"High","size":27,"edges":350,"triangles":2900,"max_degree":26,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":21},{"id":"GO:0045292","count":21},{"id":"GO:0010610","count":20},{"id":"GO:0097010","count":19},{"id":"GO:1902625","count":19}]},{"hash":"1128728378656862832","title":"Neuronal GPCR signaling and memory plasticity","description":"This cluster\u2019s top GO terms center on neural signaling and memory-related processes: long-term memory, regulation of long-term synaptic plasticity, and GPCR signaling pathways, including adenylate cyclase-inhibiting GPCR activity. Additional terms about potassium ion transport and synaptic vesicle fusion reflect neuronal excitability and synaptic regulation, supporting a theme of neuronal communication and memory formation. Some fish-specific developmental terms (lateral line) may reflect broader neural-development roles but don\u2019t override the core neural signaling/memory theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007616","count":2},{"id":"GO:1903070","count":2},{"id":"GO:0008277","count":2},{"id":"GO:0071805","count":1},{"id":"GO:0031631","count":1}]},{"hash":"1820352311018241781","title":"Genome maintenance with xenobiotic redox response","description":"Top terms point to genome maintenance processes (DNA recombination, base-excision repair) and stress responses (response to xenobiotic stimulus, cell redox homeostasis). While there are some peripheral terms, the dominant signal is DNA repair and detox/redox management, suggesting proteins involved in maintaining genome integrity under chemical stress.","confidence":"Medium","size":27,"edges":307,"triangles":2050,"max_degree":26,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0007568","count":5},{"id":"GO:0006284","count":5},{"id":"GO:0090502","count":5},{"id":"GO:0042493","count":5}]},{"hash":"2269867434654308600","title":"MAPK signaling in neural development","description":"Enriched terms point to neural development and signaling, with multiple entries for ERK and JNK cascades, axon guidance, and regulation of neuronal survival. While there are immune-related terms (T cell signaling, interferon production) and a kidney development term, the strongest and most coherent signal across the cluster is MAPK-mediated processes that drive neural differentiation, connectivity, and apoptotic regulation. Thus the label MAPK signaling in neural development captures the dominant theme.","confidence":"High","size":27,"edges":42,"triangles":3,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043525","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0001822","count":7},{"id":"GO:0050852","count":7}]},{"hash":"2162937760853550984","title":"Craniofacial and neural crest development","description":"This cluster is strongly enriched for embryonic development terms tied to craniofacial structures and neural crest\u2013derived lineages: embryonic cranial skeleton morphogenesis, odontogenesis, neural crest cell migration, and metencephalon development. Additional signals for organ induction and transcriptional regulation (RNA Pol II) support a coordinated developmental regulatory program. Overall, the dominant theme is craniofacial/neuronal crest morphogenesis during embryogenesis.","confidence":"High","size":27,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0048565","count":3},{"id":"GO:0042475","count":3}]},{"hash":"1119637501736005030","title":"Interferon-regulated transcription and endothelial adhesion","description":"The cluster centers on immune signaling via interferon production and transcriptional regulation (DNA-templated transcription, DNA binding), and additionally includes vascular development components (blood vessel maturation, cadherin-mediated cell-cell adhesion). Some glycosylation/transport terms further imply modulation of adhesion molecule maturation. Together, these suggest proteins coordinating immune transcriptional responses with endothelial cell adhesion and vascular remodeling.","confidence":"Medium","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032728","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0032727","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0001955","count":2}]},{"hash":"436225705659336458","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitination and ubiquitin-dependent degradation processes (e.g., ubiquitin-dependent protein catabolic process, autoubiquitination, and K48-linked ubiquitination), indicating the cluster centers on the ubiquitin\u2013proteasome system. Some entries touch on degradation-related pathways (ERAD, receptor catabolism) or degradation-linked processes in specific cellular contexts, but the unifying theme remains ubiquitin-mediated proteolysis and protein turnover.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":23},{"id":"GO:0051865","count":20},{"id":"GO:1900095","count":19},{"id":"GO:0070936","count":19},{"id":"GO:0016558","count":19}]},{"hash":"1006818590413915010","title":"PI3K/AKT signaling and cell polarity in development","description":"Most terms point to PI3K/AKT signaling and related cytoskeleton rearrangement and cell polarity, with angiogenesis and skeletal development indicating a developmental growth module. The immune defense and glucose-stimulated responses likely reflect broader PI3K/AKT-driven signaling cross-talk seen in metabolism and innate immunity.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0071333","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0051897","count":4}]},{"hash":"1423303401393010641","title":"Retinal Development and Axon Guidance","description":"This cluster is dominated by terms tied to eye/retinal development and neuronal pathfinding, including retinal ganglion cell axon guidance, visual perception, ephrin receptor signaling, and retinoic acid\u2013responsive processes, with supporting roles in transcriptional regulation during development. The combination points to a cohesive module focused on retinal/visual system formation and neural wiring.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0031290","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0034446","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0007601","count":3}]},{"hash":"2264709044329737097","title":"Neuronal development and axon guidance","description":"Top GO terms largely point to neuronal differentiation and connectivity: positive regulation of synapse assembly; corticospinal neuron axon guidance; auditory receptor cell development; protein localization to juxtaparanode region of axon; cellular responses related to neuronal development. These indicate a cluster centered on neuronal growth, synapse formation, and axon compartment organization. A few terms (embryonic skeletal system development, internal genitalia morphogenesis, virion attachment, phagocytosis) are more divergent and likely reflect broad developmental functions or pleiotropy, but do not override the main neuronal theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0048671","count":3},{"id":"GO:0048706","count":2},{"id":"GO:0035260","count":2},{"id":"GO:0046814","count":2}]},{"hash":"1919776225150554486","title":"RNA Pol II Transcription Repressors","description":"The top GO terms point strongly toward regulation and negative regulation of transcription by RNA polymerase II, plus general regulation of DNA-templated transcription, suggesting the proteins mainly function as transcriptional repressors or chromatin-associated regulators. A few terms (glomerulus morphogenesis, terminal button organization, interleukin-1 beta production, redox homeostasis) are more diverse and could reflect broader or context-specific roles, but the dominant pattern is transcriptional control.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0072102","count":2},{"id":"GO:0045454","count":2}]},{"hash":"798786178727838082","title":"Vesicle docking and exocytosis regulation","description":"This cluster centers on vesicle trafficking, with prominent terms for vesicle docking in exocytosis and vesicle tethering, and links to synaptic activity regulation. While there are also terms related to signaling and development (Wnt/PCP, SMAD phosphorylation, paraxial mesoderm) and apoptosis, the vesicle trafficking theme is the most recurrent signal tying the proteins together.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902187","count":2},{"id":"GO:0007182","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0006915","count":2},{"id":"GO:2000096","count":2}]},{"hash":"964439006645345020","title":"Developmental morphogenesis and cytoskeletal dynamics","description":"The GO terms cluster around cytoskeletal remodeling (microspike and stress fiber assembly), cell adhesion and spreading, and morphogenesis in developing tissues (imaginal discs, pericardium), with related processes in vascular remodeling and cell movement. Together these suggest a group of proteins coordinating shape changes and tissue formation during development via cytoskeletal regulation, even though some terms touch on related but distinct processes. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":6},{"id":"GO:0060313","count":6},{"id":"GO:0043314","count":6},{"id":"GO:0002692","count":6},{"id":"GO:0022011","count":5}]},{"hash":"665779119897188297","title":"Organogenesis and Angiogenic Signaling","description":"This cluster centers on developmental processes across multiple organs (kidney, lung, cranial skeleton), angiogenesis, and neural development (neuron migration, synapse assembly), with ERK signaling regulation and nuclear import also represented. The combination suggests a group of proteins involved in broad developmental signaling and tissue morphogenesis with vascular and neural components, though an adaptive immune term hints at broader or overlapping roles. Overall, Organogenesis and Angiogenic Signaling captures the common theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1517335595318678144","title":"Unknown","description":"The top terms span vastly different biological processes (muscle differentiation, germinal center formation, swimming, synaptic vesicle endocytosis, renal morphogenesis/absorption, chromosome passenger complex localization, B cell signaling, ubiquitin-dependent protein catabolic process, and nervous system development). With no edges and only a couple of proteins per term, there is no clear shared function or pathway tying the cluster together, so a precise label cannot be assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0036268","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0072156","count":2}]},{"hash":"862216674542958237","title":"Nervous system development and synapse assembly","description":"The cluster is dominated by GO terms related to neural development and synaptic organization, including positive regulation of synapse assembly, paranodal junction assembly, nervous system development, and localization of proteins to axon regions, indicating a coherent neural development/synapse function. A few terms touch on unrelated processes (immune/vascular), but the neural terms are the strongest signal.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0030913","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0007166","count":3},{"id":"GO:0035260","count":2}]},{"hash":"2156764252122217804","title":"Neuronal signaling and dendrite morphogenesis regulation","description":"Top GO terms center on neuronal development and signaling: regulation of dendrite morphogenesis, ephrin receptor signaling, and regulation of small GTPase\u2013mediated signaling, with additional references to glial-derived neurotrophic factor responsiveness. These suggest a theme of neuronal morphology and signaling modulation. Other terms touch on cytoskeletal dynamics (actin cytoskeleton reorganization, microvillus assembly) and growth control (TOR signaling), indicating broader regulation of cellular architecture and growth, but the neuron-focused terms provide a coherent core.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904442","count":1},{"id":"GO:1902350","count":1},{"id":"GO:0031532","count":1},{"id":"GO:0043276","count":1},{"id":"GO:0032007","count":1}]},{"hash":"1805541695137216392","title":"Integrin-Focal Adhesion Signaling and ECM Remodeling","description":"The top GO terms point to adhesion and extracellular matrix dynamics, including regulation of focal adhesion assembly, integrin-mediated signaling, hyaluronan metabolism, and metallopeptidase activity. These together suggest a cluster of proteins involved in cell-ECM interactions and remodeling, with supporting signaling cascades (e.g., JNK, PI3K) and related cytoskeletal effects. While there is a hint of neuronal signaling, the dominant theme is adhesion/ECM biology.","confidence":"High","size":26,"edges":56,"triangles":61,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051893","count":13},{"id":"GO:0048013","count":13},{"id":"GO:0030212","count":12},{"id":"GO:1905050","count":12},{"id":"GO:0007229","count":12}]},{"hash":"383665375848933450","title":"Unknown","description":"The top GO terms are a mix of signaling (intracellular signaling, NOD2 pathway, calcium release), cell cycle, sensory perception, cytoskeletal assembly, neural differentiation, chromosomal localization, and inflammatory chemokine production, with no clear single function tying them together. This cluster appears heterogeneous rather than functionally cohesive.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0035556","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0051209","count":3},{"id":"GO:0007049","count":3}]},{"hash":"926381625367582549","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":324,"triangles":2576,"max_degree":25,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0042254","count":6},{"id":"GO:0009615","count":4},{"id":"GO:0006407","count":4},{"id":"GO:0046677","count":3}]},{"hash":"597551038457570065","title":"Angiogenesis and lymphangiogenesis with basement membrane remodeling","description":"This cluster centers on vascular development and vessel remodeling, highlighted by terms for lymphangiogenesis, sprouting angiogenesis, glomerular basement membrane development, cell adhesion, and growth factor signaling (HGF receptor) plus related pathways (Wnt, Hedgehog). The complement activation term appears as a less central outlier, but the dominant theme is endothelial/vascular morphogenesis and extracellular matrix interactions.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0007155","count":4},{"id":"GO:1901492","count":3},{"id":"GO:0032836","count":3},{"id":"GO:0016055","count":3}]},{"hash":"2148740530233296541","title":"Unknown","description":"The terms include signaling (cellular response to cAMP, phosphatidylinositol dephosphorylation), redox homeostasis, mRNA stability regulation, DNA repair/recombination, and development/aging, plus seemingly unrelated terms like corneocyte development and hemolysis in another organism. There is no clear, cohesive theme tying these functions together, so a single representative label cannot be confidently assigned.","confidence":"","size":26,"edges":7,"triangles":2,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071320","count":13},{"id":"GO:0045454","count":12},{"id":"GO:0014912","count":12},{"id":"GO:0003335","count":12},{"id":"GO:0007568","count":12}]},{"hash":"393655179040803714","title":"Transcriptional Regulation and Differentiation","description":"The top GO terms point to core transcription control activities (RNA polymerase II preinitiation complex assembly, DNA-templated transcription initiation, and negative regulation of transcription). Several terms also indicate roles in cell differentiation and proliferation (granulocyte differentiation, intestinal epithelial differentiation, and stem cell proliferation), suggesting a cluster of proteins involved in regulating gene expression with downstream differentiation outcomes. Additional terms like Notch signaling regulation and glycolysis regulation hint at broader regulatory networks but do not redefine the primary theme.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":2},{"id":"GO:0051123","count":1},{"id":"GO:1903715","count":1},{"id":"GO:0006352","count":1},{"id":"GO:0045892","count":1}]},{"hash":"641239089637748634","title":"GPCR Signaling and Retina Development","description":"The dominant terms point to adenylate cyclase-activating GPCR signaling and cAMP activation, with strong associations to visual processes (visual perception and retina development). This suggests a cluster centered on GPCR-mediated signaling linked to the retina/eye function, while some other terms (e.g., electron transport, peptidoglycan catabolism) may be incidental annotations.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0045777","count":10},{"id":"GO:0035025","count":9},{"id":"GO:0007190","count":8}]},{"hash":"1729392507043065336","title":"DNA Replication and Cellular Stress Response","description":"This cluster centers on DNA metabolism (replication and biosynthesis) and stress-related processes (stress granule disassembly, hypoxia response, radiation response, toxin response), with additional signals tied to differentiation and angiogenesis. The common thread appears to be DNA maintenance coupled with cellular stress signaling and developmental regulation, suggesting these proteins coordinate replication with stress adaptation and growth control.","confidence":"Medium","size":26,"edges":107,"triangles":295,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035617","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0030855","count":3},{"id":"GO:0071456","count":3}]},{"hash":"297703443952495729","title":"Intracellular transport and signaling regulation","description":"This cluster\u2019s top GO terms emphasize intracellular protein transport and vesicle trafficking (ER-to-Golgi, endosome transport, membrane localization), along with regulation of ERK signaling and core cell cycle processes (mitotic spindle assembly, cell division). The combination suggests proteins coordinating intracellular trafficking with growth signaling and cell cycle control, rather than a single narrow function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0048804","count":2},{"id":"GO:0048280","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0006886","count":2}]},{"hash":"819842565045063844","title":"Chromatin organization and mitotic spindle control","description":"This cluster centers on chromatin-related processes (nucleosome assembly, histone modification regulation, heterochromatin formation) together with mitotic machinery (centrosome cycle, spindle assembly), suggesting a cohesive role in chromatin regulation during cell division. Obsolete GO terms reflect historical annotations but still align with chromatin state and mitosis themes.","confidence":"High","size":26,"edges":139,"triangles":340,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0061188","count":10},{"id":"GO:0007098","count":9},{"id":"GO:0051225","count":9},{"id":"GO:0006334","count":8},{"id":"GO:0061087","count":8}]},{"hash":"1071028065606921407","title":"Mitochondrial Transport and Metabolic Regulation","description":"Top GO terms point to mitochondrial transport and metabolism: heme, phosphate ion, citrate, and CoA transmembrane transport; plus regulation of mitochondrial membrane permeability and apoptotic mitochondrial changes. Additional terms reference mitochondrial genome maintenance and hormonal responses (insulin, IGF) with liver regeneration, suggesting a cluster centered on mitochondrial transport/metabolic regulation linked to hormonal signaling.","confidence":"High","size":26,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015886","count":5},{"id":"GO:0035435","count":5},{"id":"GO:0032869","count":5},{"id":"GO:0000002","count":4},{"id":"GO:0008637","count":4}]},{"hash":"2159253008532217359","title":"Nuclear transcription and chromatin modification","description":"This cluster is enriched for core nuclear processes: mRNA processing and DNA-templated transcription, along with histone modification (acetylation/methylation), which point to regulation of gene expression at the chromatin and RNA-processing levels. Some terms like viral mRNA export and developmental processes appear as peripheral annotations, but the dominant theme centers on transcriptional control and chromatin state in the nucleus.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":4},{"id":"GO:0010745","count":3},{"id":"GO:0043981","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0007338","count":2}]},{"hash":"1832927855022482147","title":"Unknown","description":"The GO terms span vitamin D response, spindle assembly, adipocyte differentiation, foam cell differentiation, nociception, chromosome telomere localization, actin bundle assembly, chemokine production, skeletal muscle regeneration, and dendrite development\u2014covering diverse, seemingly unrelated processes with no single unifying function. Therefore, a coherent, specific label is not apparent.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0051225","count":5},{"id":"GO:0045444","count":5},{"id":"GO:0010745","count":5},{"id":"GO:0050968","count":4}]},{"hash":"618658165606393206","title":"Craniofacial development and ECM remodeling","description":"The cluster\u2019s terms center on embryonic cranial skeleton morphogenesis, hyaluronan biosynthesis, proteolysis, and wound healing, pointing to extracellular matrix remodeling during development. Additional terms on multicellular development and Rho signaling support a morphogenesis/motility theme; some head/ear-related functions (sensory perception of sound, synapse organization) fit within craniofacial development contexts. Overall, the shared theme appears to be developmental processes in the head region with ECM dynamics.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060054","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0007605","count":2}]},{"hash":"437984302514417989","title":"GABAergic GPCR Signaling in Neurons","description":"The top GO terms point to neuronal signaling with GPCR pathways and GABA involvement, including inhibition of synaptic vesicle fusion, G protein-coupled receptor signaling, and GABA signaling, complemented by sensory perception and neuronal excitability terms (taste, light perception, electrical stimulus, potassium transport). This suggests a cohesive cluster of proteins functioning in inhibitory GPCR-mediated synaptic transmission and broader sensory/neural signaling.","confidence":"High","size":26,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031631","count":2},{"id":"GO:0007196","count":2},{"id":"GO:0001661","count":2},{"id":"GO:0051930","count":2},{"id":"GO:0050908","count":2}]},{"hash":"154199296727169857","title":"Pain perception and neuronal excitability","description":"Based on the top GO terms, the cluster is enriched for detection of chemical and mechanical stimuli involved in sensory perception of pain, along with neuronal action potential and calcium-channel\u2013mediated membrane depolarization. This points to a theme of pain signaling and neuronal excitability, despite a few unrelated terms (protein repair, pancreatic cell apoptosis). Overall, the proteins appear to be linked to sensory signaling and neural activity.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":3},{"id":"GO:0050966","count":3},{"id":"GO:0030091","count":2},{"id":"GO:0019228","count":2},{"id":"GO:0061577","count":2}]},{"hash":"933390058099223660","title":"Vertebrate Development and Hormone Secretion","description":"The top GO terms cluster around vertebrate development and endocrine signaling: heart-related morphogenesis (atrial septum morphogenesis, endocardial cushion development, mesodermal-to-mesenchymal transition in gastrulation) and reproductive hormone activity (luteinizing and follicle-stimulating hormone secretion), with a fertilization-related term (penetration of zona pellucida) as additional context. A couple of general cellular processes appear, but the dominant theme points to developmental and endocrine functions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0030643","count":2},{"id":"GO:0007341","count":1},{"id":"GO:0001661","count":1},{"id":"GO:0032275","count":1}]},{"hash":"1034988217879565939","title":"Developmental Patterning and Organogenesis","description":"Top GO terms cluster around embryonic development, organ morphogenesis (eye/retina, brain, viscerocranium, palate, haltere, antennal segments), and regulation of transcription, suggesting a cohesive set of genes driving developmental patterning and formation across tissues and species.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0043010","count":2},{"id":"GO:0048703","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0007420","count":2}]},{"hash":"550090367999544760","title":"Core cellular growth and division machinery","description":"This cluster gathers proteins involved in fundamental cellular processes such as ribosome biogenesis and export, transcription, cell division and cytokinesis, vesicle docking, and apoptosis, suggesting a cohesive theme of core growth, protein synthesis, and division machinery. A neuronal development term appears but is not central to the overall pattern.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0006904","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007107","count":2}]},{"hash":"1688175713886057237","title":"Mitochondrial translation machinery","description":"The cluster is dominated by GO terms for translation and multiple mitochondrial tRNA aminoacylation activities (glycyl-, prolyl-, threonyl-, histidyl-), along with mitochondrial DNA metabolic process. This pattern strongly suggests a group of proteins involved in mitochondrial gene expression and protein synthesis, i.e., the mitochondrial translation apparatus. Some terms like angiogenesis or in utero embryonic development appear secondary or broader, but the core signal supports mitochondrial translation as the defining function. RECIPE re-additions imply a cohesive set of related proteins.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0071897","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0070150","count":2},{"id":"GO:0006433","count":2}]},{"hash":"739425210921697677","title":"Cerebellar neural development and signaling","description":"This cluster is enriched for terms tied to cerebellar development, such as cerebellar cortex formation and Bergmann glial cell differentiation, along with neural repair (axon regeneration) and neural signaling pathways. While there are also general cell-cycle and insulin signaling terms, the dominant themes point to cerebellar neural development and associated signaling processes, supporting this label with moderate confidence.","confidence":"Medium","size":26,"edges":29,"triangles":5,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008285","count":22},{"id":"GO:0050852","count":22},{"id":"GO:0006260","count":22},{"id":"GO:0008286","count":21},{"id":"GO:0060020","count":21}]},{"hash":"2101391300827348090","title":"Neural signaling and metabolic regulation","description":"This cluster centers on neural-related processes (visual learning, excitatory postsynaptic potential, response to cocaine) but also includes metabolic and endocrine pathways (glucose metabolism, insulin signaling, thyroid development), suggesting proteins involved in neural signaling with metabolic and hormonal regulation. ","confidence":"Medium","size":26,"edges":324,"triangles":2576,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":26},{"id":"GO:0047484","count":26},{"id":"GO:0008285","count":26},{"id":"GO:0060079","count":26},{"id":"GO:0042220","count":26}]},{"hash":"334361912315621861","title":"Developmental transcriptional regulation in muscle and nerve","description":"The top GO terms point to transcriptional control (negative regulation of RNA Pol II and transcription by Pol II) along with development-related processes such as skeletal muscle development and nervous system development, plus muscle differentiation. Although other terms are diverse (germinal center formation, plant brassinosteroid signaling, swimming, distal tubule morphogenesis), the prevailing pattern is regulation of gene expression during muscle and neural development, justifying this label.","confidence":"Medium","size":26,"edges":11,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1903026","count":5},{"id":"GO:0007519","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0035914","count":4}]},{"hash":"1682359616807288953","title":"Histone Demethylation and Transcription Regulation","description":"The top terms emphasize histone demethylation (H3-K4 and H3-K36), DNA-templated transcription, and regulatory roles in differentiation and signaling (Notch, myoblast differentiation), pointing to epigenetic control of gene expression and developmental transcription programs. Some unrelated terms appear (lipoteichoic acid biosynthesis), likely noise. ","confidence":"High","size":26,"edges":23,"triangles":2,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034720","count":6},{"id":"GO:0045746","count":6},{"id":"GO:0070395","count":6},{"id":"GO:0042265","count":5},{"id":"GO:0061428","count":5}]},{"hash":"354107706373917805","title":"Synaptic Ion Transport and Rho Signaling","description":"The cluster shows enriched GO terms for chemical synaptic transmission, various ion transports across membranes, and synapse organization/localization, along with regulation and activation of Rho GTPase signaling. This suggests proteins operating at the synapse that couple ion transport with Rho-regulated signaling to modulate synaptic function and structure.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007268","count":2},{"id":"GO:0006814","count":2},{"id":"GO:0055085","count":2},{"id":"GO:0071805","count":2}]},{"hash":"1457075505231196363","title":"Intracellular Trafficking and Cytoskeletal Dynamics","description":"The top GO terms cluster around vesicle transport between ER-Golgi and endosomes, and general intracellular protein transport, alongside actin filament severing. Additional terms cover mitotic structures (spindle assembly, centrosome cycle) and cellular stress responses (apoptosis, redox homeostasis), implying a module focused on trafficking and cytoskeletal remodeling with links to cell cycle and survival. Overall, the proteins appear to form a coherent group centered on intracellular transport and cytoskeletal regulation, with auxiliary roles in division and apoptosis.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0051014","count":2}]},{"hash":"277005177319486673","title":"Ubiquitin-regulated tissue development","description":"Top GO terms point to ubiquitin-dependent protein catabolic processes and K33-linked ubiquitination, with several development-related terms across skeletal muscle, hair follicle morphogenesis, distal tubule morphogenesis, and renal function, plus immune signaling and circadian rhythm terms. This suggests the cluster centers on ubiquitin-mediated regulation influencing diverse tissue development and function, though the exact connections vary across the included processes.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0050853","count":5},{"id":"GO:0031069","count":4},{"id":"GO:0002467","count":4},{"id":"GO:0072156","count":4}]},{"hash":"637855493148605628","title":"Collagen ECM Remodeling and Immune Regulation","description":"This cluster centers on extracellular matrix organization (collagen fibril organization) and vascular regulation (negative regulation of angiogenesis), with immune activity signals (defense response to Gram-positive bacteria, B cell proliferation) and cell adhesion/mechanical sensing, suggesting a module combining ECM remodeling with immune signaling. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0002322","count":3}]},{"hash":"691679455885501151","title":"Nervous system development and synaptic trafficking","description":"The top GO terms point to neuronal and synaptic functions, including sensory perception of sound, adult locomotory behavior, peripheral nervous system myelin maintenance, and clathrin-dependent endocytosis with vesicle budding at presynaptic zones. Small GTPase signaling also aligns with neuronal trafficking and membrane dynamics. A few terms (like heart development and obsolete signals) seem incidental, but the dominant theme is nervous system development/maintenance and synaptic vesicle trafficking.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901998","count":4},{"id":"GO:0016185","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0008344","count":4},{"id":"GO:0051092","count":4}]},{"hash":"159505278832030641","title":"Cerebellar neuron development and synaptic organization","description":"Top terms center on synapse organization and cerebellar Purkinje cell layer formation, suggesting a cluster tied to cerebellar neuron development and synaptic architecture. Supporting terms related to neural signaling pathways (Rho, Wnt) and behavior regulation reinforce a neural development/synaptic function theme with cerebellar specificity.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0050808","count":7},{"id":"GO:0035023","count":7},{"id":"GO:2000670","count":6},{"id":"GO:0021694","count":6},{"id":"GO:0008285","count":6}]},{"hash":"995090715036841703","title":"Unknown","description":"The terms span diverse processes\u2014Rho signaling, growth factor responses (GM-CSF, EGF), neural development (dendritic spine), sensory/locomotor functions, cardiac development, B cell homeostasis, membrane tubulation, and ion transport\u2014showing no single unifying function for the cluster.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0061000","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0010765","count":3}]},{"hash":"1815147639512123420","title":"Cell Cycle and Intracellular Transport","description":"This cluster's prominent terms center on mitosis and vesicle trafficking (mitotic spindle assembly; mitotic sister chromatid cohesion; an APC-dependent catabolic process; COPII-coated vesicle budding; nuclear pore localization). A couple of terms point to eye development (retina and lens differentiation) which may reflect tissue-specific expression rather than a cohesive functional module. Overall, the recurring theme is core cellular organization involving cell division and intracellular transport.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0001845","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0031081","count":3},{"id":"GO:0090307","count":3}]},{"hash":"1611369401367161896","title":"Neural crest migration and neural connectivity development","description":"The terms point to neural crest\u2013derived processes (neural crest cell migration, sympathetic nervous system development) and neuronal connectivity (axonal fasciculation, dendrite self-avoidance, synapse assembly), with skeletogenic terms (ossification, bone maturation) likely reflecting crest\u2011derived bone formation. Together they suggest a cluster focused on neural crest\u2013driven neural development and associated skeletal development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0001756","count":2},{"id":"GO:0036486","count":2},{"id":"GO:0010693","count":2},{"id":"GO:1900220","count":2}]},{"hash":"1102926305358685676","title":"Negative regulation of receptor tyrosine kinase signaling","description":"The cluster is dominated by terms about inhibiting tyrosine kinase\u2013driven pathways (MAPK/ERK cascades, T cell receptor signaling, insulin receptor signaling) and dephosphorylating tyrosine residues on kinases. This points to a coherent function centered on protein tyrosine phosphatase activity dampening receptor tyrosine kinase signaling and related proliferative responses, including regulation of oligodendrocyte progenitor proliferation and cell population growth.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":24},{"id":"GO:0070373","count":24},{"id":"GO:0050860","count":24},{"id":"GO:1990264","count":18},{"id":"GO:0061097","count":18}]},{"hash":"1743452828180603382","title":"Neural development and synaptic signaling with cytoskeleton","description":"These terms collectively emphasize neural communication and development (pain perception, dendrite regulation, synaptic plasticity, calcium signaling) and cytoskeletal dynamics (actin bundle assembly), with additional signals related to glial differentiation and muscle turnover, suggesting a cluster centered on neural development and signaling intertwined with cytoskeletal remodeling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":3},{"id":"GO:0070198","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0048709","count":3},{"id":"GO:0071651","count":3}]},{"hash":"997012835927386858","title":"mRNA processing and translation regulation","description":"The top GO terms cluster around regulation of mRNA splicing (positive and negative via the spliceosome), mRNA stability and poly(A) tail dynamics under stress, ncRNA-mediated gene silencing, and steps in translation initiation (eIF4F complex assembly and IRES-dependent initiation). This points to a cohesive theme centered on RNA maturation/processing and control of translation, possibly in stress or viral contexts.","confidence":"High","size":25,"edges":157,"triangles":342,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":16},{"id":"GO:0048025","count":15},{"id":"GO:0031047","count":15},{"id":"GO:0048026","count":15},{"id":"GO:0006378","count":14}]},{"hash":"619899972961261186","title":"Multilineage Development and Differentiation","description":"The listed GO terms cluster around tissue- and cell-type specific development and differentiation across immune (B cell receptor signaling, dendritic cell differentiation), neural (paranodal junction assembly, corpus callosum development, motor neuron axon fasciculation), muscular (skeletal muscle tissue development), and placental/trophoblast lineages, with additional general processes like DNA replication initiation and DNA repair that support cell division. The common thread is developmental/differentiation processes across multiple tissues rather than a single pathway, and there is no strong interaction network evident (Edges 0). ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0050853","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0007519","count":2}]},{"hash":"1023748522189185777","title":"Nuclear Transport and Transcription Regulation","description":"The top GO terms cluster around nuclear processes (mRNA export, ribosomal subunit export, import of NLS-containing proteins) and transcriptional regulation (negative regulation of RNA polymerase II), with additional links to protein modification (desumoylation) and development signaling (Wnt-related terms, endodermal fate). This suggests a core theme of nuclear transport coordinating transcriptional control, with some accompanying signaling/regulatory roles.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044336","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0060188","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0001711","count":2}]},{"hash":"422370475007181993","title":"Cross-tissue Development and Differentiation","description":"The prominent GO terms span developmental and differentiation processes across multiple tissues (pericardium morphogenesis, brain and gonad development, keratinocyte differentiation, and its regulation), with supporting terms on protein localization and oligomerization that hint at signaling complexes involved in development. This points to a broad developmental/differentiation program rather than a single, tight pathway.","confidence":"Medium","size":25,"edges":86,"triangles":109,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0003344","count":3},{"id":"GO:0034394","count":3},{"id":"GO:2001027","count":3},{"id":"GO:0030195","count":3},{"id":"GO:2001205","count":3}]},{"hash":"1351560876822772237","title":"Neural development and synaptic organization","description":"Most top GO terms point to nervous system development and synaptic function, including retina development, inhibitory synapse assembly, synaptic vesicle clustering, terminal button organization, and receptor recycling, suggesting a cohesive theme of neuronal development and synaptic architecture. Transcription by RNA polymerase II supports active neural gene expression, while some terms like xenobiotic response may reflect broader cellular regulation; an unrelated osteoblast development term appears incidental. ","confidence":"Medium","size":25,"edges":296,"triangles":2212,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002087","count":12},{"id":"GO:0060041","count":12},{"id":"GO:0002076","count":12},{"id":"GO:0006366","count":11},{"id":"GO:0042493","count":9}]},{"hash":"294760281453501814","title":"Unknown","description":"The top GO terms span vertebrate development (bone, uterus), growth factor signaling (PDGF receptor pathway), cytoskeletal/adhesion regulation (Rho signaling, cell adhesion, cell shape), transcriptional regulation, immune activity (complement pathway), and even bacterial cell wall processes (peptidoglycan biosynthesis, cell wall organization). With no edges or triangles and no clear shared function among these terms, there is no cohesive theme connecting the proteins into a single interpretable cluster.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":2},{"id":"GO:0048008","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0007155","count":2}]},{"hash":"1395878812197895970","title":"Neural development and synaptic signaling","description":"This cluster is dominated by terms relating to brain development (corpus callosum development), synapse assembly, and neural signaling pathways (neurotrophin TRK signaling, calcium-mediated signaling), as well as related behavioral responses (pain, cocaine) that imply neuronal communication and connectivity rather than metabolic or secretory functions. While a few terms like innate immune response appear, the strongest consistent theme centers on neural development and synaptic activity.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0022038","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0051092","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0048011","count":6}]},{"hash":"701616400118723931","title":"Neurodevelopment and Golgi\u2013ER Transport","description":"The cluster\u2019s top GO terms cluster around neural/sensory development (retina development, brain development, lens fiber cell differentiation) and vesicle trafficking between the Golgi and ER (anterograde and retrograde transport), with positive regulation of GTPase activity supporting trafficking regulation. The combination suggests proteins involved in developmental processes in neural/eye tissues linked to intracellular transport and signaling, rather than a single isolated pathway. Other terms like muscle/skeletal development and RNA processing appear less central to the main theme but indicate broad cellular roles. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006890","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1795127328037041226","title":"Cell growth and signaling regulation","description":"This cluster gathers proteins involved in essential growth and signaling processes: tyrosine phosphorylation signaling, ubiquitin-proteasome\u2013mediated proteolysis, cell division, ribosome biogenesis, actin cytoskeleton remodeling (Arp2/3), transcription, GTPase signaling, and TGF-beta response. The presence of development and signaling terms suggests a coordinated role in growth, proliferation, and gene expression rather than a single specific pathway. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050731","count":4},{"id":"GO:0031146","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:2000601","count":3}]},{"hash":"1466320509176683962","title":"Unknown","description":"The top GO terms span inflammatory signaling (TNF pathway, NF-kB regulation) and LPS response, apoptosis, and diverse developmental/physiological processes (cartilage development, ossification, lipoprotein clearance, renal albumin absorption). There is no single cohesive biological process or pathway tying these proteins together, so a unified label cannot be inferred.","confidence":"","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042347","count":1},{"id":"GO:0033209","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0042771","count":1},{"id":"GO:0034051","count":1}]},{"hash":"296360096910914503","title":"Synaptic localization and spine morphogenesis","description":"Proteins in this cluster are enriched for GO terms related to synapse localization, dendritic spine morphogenesis, receptor clustering, and Rho signaling, suggesting a common role in synapse assembly and spine remodeling. Some terms (e.g., mitotic spindle checkpoint signaling and certain hormone-related processes) are less directly linked and may reflect broader cellular roles or annotation noise, but the dominant theme points to synaptic organization and spine dynamics.","confidence":"High","size":25,"edges":44,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0035418","count":2},{"id":"GO:0007266","count":2},{"id":"GO:0043113","count":2}]},{"hash":"2278286071625091589","title":"Fatty acid biosynthesis and lipid metabolism","description":"The dominant terms relate to fatty acid biosynthesis, long- and medium-chain fatty acid metabolism, and fatty acid import, with lipoteichoic acid and menaquinone biosynthesis indicating bacterial lipid/isoprenoid pathways. The presence of seed-related terms and bioluminescence appears as annotation noise rather than a unifying theme, so the core cluster label centers on lipid metabolism. ","confidence":"Medium","size":25,"edges":218,"triangles":933,"max_degree":24,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0070395","count":11},{"id":"GO:0008218","count":10},{"id":"GO:0001676","count":10},{"id":"GO:0009234","count":10},{"id":"GO:0010214","count":10}]},{"hash":"866918390034885678","title":"Growth control and differentiation signaling","description":"This cluster is enriched for terms tied to cell proliferation and fate decisions (mitotic cell cycle, DNA replication, apoptotic process), tissue differentiation (keratinocyte differentiation), and key growth-regulating pathways (Hippo, canonical Wnt) along with nuclear transport regulation (protein import/export). Together these suggest a cohesive theme of growth control, proliferation, and differentiation signaling in tissue contexts, despite an outlier term related to visual perception. ","confidence":"High","size":25,"edges":132,"triangles":339,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":22},{"id":"GO:0000278","count":22},{"id":"GO:0060044","count":21},{"id":"GO:0030216","count":21},{"id":"GO:0033160","count":21}]},{"hash":"27864346665443723","title":"Neuromuscular signaling and RNAi machinery","description":"The terms strongly point to neuromuscular functions (neural transmission, innervation, motor behavior, neuromuscular process controlling posture). A subset links to transcriptional and post-transcriptional regulation, including RISC complex assembly, suggesting RNAi-related components that may interface with neuromuscular control. Some developmental terms are present, but the dominant theme appears to be neuromuscular signaling with RNAi-related regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007274","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0044387","count":1},{"id":"GO:1900369","count":1},{"id":"GO:0048899","count":1}]},{"hash":"1045109374075377368","title":"Developmental patterning and morphogenesis","description":"The top GO terms point to embryonic development and tissue formation across multiple organs (neural tube closure, left-right patterning, hair follicle morphogenesis, pancreatic cell development). Supporting terms about photoreceptor maintenance, epithelial proliferation regulation, and signaling (prostaglandin response, xenobiotic response, JUN kinase regulation) suggest broader developmental signaling and tissue maintenance roles. Together, these indicate a cohesive theme of developmental patterning and morphogenesis, even though there are no observed interactions within the cluster.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0050680","count":2},{"id":"GO:0042493","count":2}]},{"hash":"96015847255004915","title":"Wnt signaling and neural development regulators","description":"The strongest shared functions are modulation of canonical Wnt signaling and neural development processes (axonogenesis, synapse organization). Additional GO terms reflect broader signaling regulation (JNK, NF-kB) and apoptosis, but the core theme points to regulators of Wnt-driven neural development. Bone development is a minor association. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000009","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0010793","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1081027705884314525","title":"Cardiac Development and Energy Metabolism","description":"This cluster centers on heart-related terms (heart development, cardiac muscle cell differentiation) suggesting proteins involved in cardiac lineage and development. The accompanying metabolic terms (carnitine metabolism, long-chain fatty acid catabolism, leucine catabolic process) point to mitochondrial energy pathways characteristic of cardiac tissue. Additional terms for oxidative stress responses (hydrogen peroxide, cold) fit the cardiac/ cellular stress context, supporting a theme of cardiac development plus metabolic readiness. Overall, the terms cohere around cardiac formation and energy metabolism rather than a single unrelated function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0051291","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0055007","count":2},{"id":"GO:0006552","count":2}]},{"hash":"1343297097867426741","title":"Unknown","description":"The top GO terms span immune activation (germinal center formation, IL-12 regulation, NF-kB activity), viral-host interaction, oxidative and mechanical stress responses, and tissues-specific processes (muscle stretch, SA node/heart-related terms, hepatocyte apoptosis), indicating no single cohesive function links the proteins.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002467","count":3},{"id":"GO:0032088","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0045083","count":2},{"id":"GO:0071260","count":2}]},{"hash":"642182048116771864","title":"Unknown","description":"The GO terms span diverse biological processes\u2014from ischemia response and anesthetic response to neural development, memory, germ-line maintenance, immune signaling, and ion transport\u2014without a unifying function. With no edges or cohesive functional module, it's not possible to assign a single interpretable label beyond Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0002931","count":4},{"id":"GO:2000746","count":3},{"id":"GO:0035545","count":3},{"id":"GO:0072375","count":3},{"id":"GO:0006811","count":3}]},{"hash":"416636023563371754","title":"Transcription Regulation and Intracellular Signaling","description":"The dominant GO terms point to transcriptional regulation (both activation and repression) and intracellular signaling, with supporting roles in phosphorylation and protein trafficking. This combination suggests proteins that modulate gene expression and coordinate intracellular transport and signaling rather than a single pathway, aligning with the proposed label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045494","count":2},{"id":"GO:1902953","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0018105","count":2},{"id":"GO:0035556","count":2}]},{"hash":"539023452818690533","title":"Brassinosteroid Biosynthesis and Plant Epidermal Development","description":"The cluster\u2019s strongest signals are brassinosteroid biosynthetic process and brassinosteroid homeostasis, along with trichome papilla formation, pointing to plant steroid hormone production and epidermal development. Fatty acid elongation complements membrane dynamics in growing epidermal tissues. Some animal steroid terms appear, but the dominant plant-centric theme supports this label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030497","count":2},{"id":"GO:0006702","count":2},{"id":"GO:0030539","count":2},{"id":"GO:0016132","count":2},{"id":"GO:1905499","count":2}]},{"hash":"535635436302065505","title":"Neural development and GABAergic synaptic transmission","description":"This cluster is dominated by terms related to nervous system development, synapse assembly and GABAergic signaling, including synaptic transmission, paranodal junctions, and dendritic spine modulation, suggesting a cohesive set of neural connectivity and communication proteins. A couple of peripheral terms (sensory perception of sound and ossification) are less aligned but do not override the main neural theme.","confidence":"Medium","size":24,"edges":14,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0051932","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1560558652477282951","title":"Embryonic development and organ morphogenesis","description":"The top GO terms cluster around broad developmental processes across multiple tissues (primitive streak formation, neural crest migration, cartilage and organ morphogenesis including kidney, pancreas, midbrain, and peripheral nervous system), with an additional note on transcriptional regulation. This points to a general developmental/morphogenetic theme rather than a single pathway, justifying a label for embryonic development and organ morphogenesis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0090009","count":5},{"id":"GO:0051216","count":5},{"id":"GO:0090190","count":5},{"id":"GO:0001755","count":5}]},{"hash":"1120651443600455951","title":"Hypoxia-Associated Developmental Growth Signaling","description":"This cluster combines GO terms for cellular response to hypoxia, skin and multicellular development, mitotic cell cycle, and positive regulation of various signaling activities (GTPase activity, protein autophosphorylation, serine/threonine kinase activity), suggesting a module coordinating hypoxic stress with developmental growth and proliferation, despite some less central terms like aging.","confidence":"Medium","size":24,"edges":21,"triangles":7,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0007568","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051028","count":4}]},{"hash":"1948639866779519968","title":"Thermogenesis-driven energy metabolism and GPCR signaling","description":"Reason: The cluster is dominated by energy metabolism and thermogenesis signals (diet-induced thermogenesis, electron transport chain, membrane potential) and GPCR signaling terms (adenylate cyclase-activating GPCR signaling), pointing to a metabolic-neural regulatory module. While some terms indicate systemic physiology (blood pressure, saliva), the core theme ties energy production to signaling and temperature response.","confidence":"Medium","size":24,"edges":223,"triangles":1064,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":14},{"id":"GO:0010579","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0002024","count":12},{"id":"GO:0022900","count":12}]},{"hash":"2292362240958719607","title":"DNA Damage Response & Apoptosis","description":"This cluster is dominated by GO terms for DNA repair (base-excision repair; DNA recombination) and programmed cell death (apoptosis), with redox homeostasis suggesting stress signaling. While some terms are less related, the core theme ties to maintaining genome integrity and regulating cell fate under stress.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":7},{"id":"GO:0006915","count":7},{"id":"GO:0045454","count":6},{"id":"GO:0014912","count":6},{"id":"GO:0003335","count":6}]},{"hash":"1055672654006265065","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":2},{"id":"GO:0007200","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000398","count":2}]},{"hash":"1806629192018527593","title":"Telomere maintenance and localization","description":"The top GO terms are dominated by telomere-related processes: protein localization to the telomeric region and positive regulation of telomere maintenance via telomerase, plus a term on telomeric chromatid cohesion. Although other terms touch on development and signaling, the clearest shared theme across the cluster is telomere biology and chromosome-telomere maintenance, suggesting these proteins collectively relate to telomere regulation or localization.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070198","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0060157","count":2},{"id":"GO:1904908","count":2},{"id":"GO:0007205","count":2}]},{"hash":"1452333758364783093","title":"Neural development and retina-associated junctions","description":"Based on the Top Terms, this cluster centers on vision-related processes (visual perception, retina vasculature development) and neural cell interfaces (paranodal and smooth septate junction assembly), with additional signals related to neural development (microglia development) and Notch signaling. The mix suggests a group of proteins involved in CNS/retinal development and cellular junctions, rather than a single isolated pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901223","count":3},{"id":"GO:0061298","count":2},{"id":"GO:0090528","count":2},{"id":"GO:0030913","count":2},{"id":"GO:0043128","count":2}]},{"hash":"1891358455121244056","title":"B cell activation and antibody production signaling","description":"The top GO terms cluster around immune signaling and B cell-related processes, including regulation of IgA class switching, chemokine production, and B cell apoptotic regulation, along with transcriptional regulation and signaling pathways. The presence of extracellular exosome assembly and prostaglandin biosynthesis further supports a role in immune communication and B cell\u2013mediated responses.","confidence":"Medium","size":24,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:2000343","count":2},{"id":"GO:0023019","count":2},{"id":"GO:0048298","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0033138","count":2}]},{"hash":"105396481453501602","title":"Unknown","description":"The top GO terms span reproduction (sperm capacitation), neural signaling and development (excitatory postsynaptic potential, axonogenesis, long-term potentiation, visual perception), plant hormone signaling (abscisic acid-activated), basic cellular processes (ribosomal export, mitotic cell cycle, DNA replication initiation, protein phosphorylation). There is no single cohesive theme tying these functions together, so no specific, representative label can be assigned beyond Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0010800","count":2}]},{"hash":"1209566301631235193","title":"Chromatin, nuclear transport, and cell cycle regulation","description":"The terms cluster around chromatin organization and histone modification, nuclear pore localization, and mitotic spindle assembly, plus supporting signals in TORC1 regulation and protein ubiquitination. Cilium assembly and development-related terms suggest broader growth/development roles, but the core theme ties to chromatin, nuclear transport, and cell cycle control.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0060770","count":4},{"id":"GO:1904263","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0070262","count":3},{"id":"GO:0043966","count":3}]},{"hash":"1863882630997062050","title":"Zinc Transport and Golgi Trafficking","description":"The GO terms cluster around zinc ion transport/homeostasis and intracellular membrane trafficking (endocytosis, Golgi-ER retrograde transport, vesicle budding), indicating proteins involved in zinc handling linked to vesicle trafficking.","confidence":"High","size":24,"edges":37,"triangles":4,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071577","count":4},{"id":"GO:0070574","count":4},{"id":"GO:0006897","count":4},{"id":"GO:0006882","count":4},{"id":"GO:0071230","count":4}]},{"hash":"1958543349226030067","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001403","count":3},{"id":"GO:0051534","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0000278","count":2}]},{"hash":"2060566081347941891","title":"Mitotic regulation and stress-response","description":"The cluster's top GO terms point to mitotic processes (cell division, APC-dependent catabolic process, mitotic cell cycle) and multiple stress-related responses (cellular response to hydrogen peroxide, cadmium ion, and defense against virus) as well as ubiquitin-mediated regulation (K11-linked ubiquitination). Together, these terms suggest a cohesive theme around cell-cycle control coupled with cellular stress signaling and targeted protein turnover. The photoreceptor maintenance term may reflect tissue-specific roles unrelated to core mitotic function, but does not dominate the cluster's function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0045494","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0048873","count":2}]},{"hash":"980452742462400876","title":"Embryonic Organogenesis and Transcriptional Regulation","description":"The major themes are embryonic development and organ formation, evidenced by multiple GO terms for heart, pancreas, midbrain, cranial skeleton morphogenesis, and organ induction. The presence of negative regulation of transcription by RNA polymerase II suggests regulatory control of gene expression during development, which fits a cohesive developmental cluster. An outlier term for complement activation appears incidental rather than core to the cluster\u2019s function. Overall, the proteins seem to participate in embryonic organogenesis and its regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030901","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0003148","count":4},{"id":"GO:0061113","count":4}]},{"hash":"1898802780130843520","title":"ER-Golgi Transport and Wnt Secretion","description":"This cluster is dominated by GO terms for ER-to-Golgi vesicle trafficking, COPI vesicle formation and budding, Golgi ribbon assembly, ER lumen protein retention, and enhanced ER exit, all of which point to a cohesive secretory pathway function. The presence of Wnt protein secretion and related regulatory terms reinforces a specific focus on secretion of signaling ligands. Developmental terms like placenta formation and dorsal-ventral axis specification likely reflect contexts where this secretory machinery is active, but do not override the core trafficking theme.","confidence":"High","size":24,"edges":17,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0001893","count":2},{"id":"GO:0007311","count":2},{"id":"GO:0090161","count":2},{"id":"GO:0048205","count":2}]},{"hash":"1460519239549684155","title":"Innate immune response and inflammasome signaling","description":"This cluster shows enrichment for innate immune response and positive regulation of NLRP3 inflammasome complex assembly, suggesting a core theme around inflammatory signaling. While there are some hints of extracellular matrix remodeling and muscle-related processes, the immune-related terms are most prominent, supporting a primary function in innate immunity and inflammasome regulation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900227","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0035914","count":1}]},{"hash":"2160492360392685946","title":"Unknown","description":"The top terms span multiple unrelated biological themes\u2014from developmental processes (bone marrow, nipple morphogenesis, ventral spinal cord, lung connective tissue) to immune complement activation and neuronal/APP-related processes, plus obsolescent terms about endosome transport and amyloid precursor protein catabolism. There is no coherent, shared function or pathway tying all proteins together, so a single confident label cannot be assigned beyond Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010899","count":1},{"id":"GO:0060658","count":1},{"id":"GO:0048539","count":1},{"id":"GO:1902960","count":1},{"id":"GO:1902963","count":1}]},{"hash":"2075953039297963989","title":"Planar polarity and tissue morphogenesis","description":"This cluster is dominated by GO terms related to planar polarity (establishment of planar polarity, body hair planar orientation, protein localization involved in planar polarity) and developmental morphogenesis (lung morphogenesis, nephron tubule differentiation, synapse assembly, cell adhesion). ER protein folding and redox homeostasis appear less central but may reflect general cellular stress responses accompanying development. Overall, the common theme is polarity-guided tissue organization and morphogenesis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0034975","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0045317","count":2},{"id":"GO:0048105","count":2}]},{"hash":"430116663369157624","title":"Cell-Cell Communication and Adhesion","description":"This cluster centers on processes related to how cells interact and communicate with each other, including synapse organization, cell\u2013cell and cell\u2013matrix adhesion, and modulation of immune cell activity. The presence of antigen presentation via MHC I and growth-factor\u2013related signaling (VEGF/PDGF pathways) suggests both immune surveillance and broader development/vascular signaling, implying a general theme of cell-cell communication and adhesion rather than a single, cohesive pathway. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050808","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0035260","count":2},{"id":"GO:0042590","count":2},{"id":"GO:0090673","count":2}]},{"hash":"507443438779247783","title":"Neural and muscle development signaling","description":"The cluster contains GO terms spanning neural development (axonogenesis, visual perception, glutamate secretion), and signaling modulation (protein dephosphorylation, negative regulation of protein kinase activity), plus muscle/ECM-related processes (collagen fibril organization, satellite cell activation for skeletal muscle regeneration) and responses to mechanical stimuli and endothelial migration. This combination suggests a broad theme of development and signaling in neural and musculoskeletal contexts, rather than a single, tightly defined pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":3},{"id":"GO:0010596","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0014068","count":3}]},{"hash":"178181094102829732","title":"Aminoacyl-tRNA Synthetases and Translation","description":"The top GO terms include glycyl-, leucyl-, histidyl-, and glutamyl-tRNA aminoacylation along with translation, which together strongly indicate a core set of proteins involved in protein synthesis and aminoacylation. Other terms such as muscle contraction, heart morphogenesis, angiogenesis, and interferon response are less represented and may reflect broader or secondary roles. Thus, the primary theme is translation machinery centered on aminoacyl-tRNA synthetases.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031443","count":2},{"id":"GO:0003151","count":2},{"id":"GO:0006426","count":1},{"id":"GO:0071346","count":1},{"id":"GO:0001525","count":1}]},{"hash":"1482113215858380053","title":"Adaptive Immune Signaling","description":"The top GO terms are dominated by adaptive immune processes (IL-2 production, B cell receptor signaling, Fc-epsilon receptor signaling, and adaptive immune response), indicating the proteins mainly cluster around immune activation and signaling pathways, with a few unrelated terms likely incidental.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900042","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0050853","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0038095","count":2}]},{"hash":"253436953726109842","title":"Embryonic morphogenesis and patterning","description":"The top GO terms cluster around developmental processes across multiple tissues\u2014eye/lens formation, forebrain patterning, mesoderm formation, cartilage/bone morphogenesis, and heart field specification\u2014with some regulatory processes (Wnt signaling and ubiquitin ligase activity). This suggests proteins in the cluster are broadly involved in embryonic morphogenesis and patterning rather than a single pathway, supporting the label \"Embryonic morphogenesis and patterning.\"","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035414","count":1},{"id":"GO:0001957","count":1},{"id":"GO:0001743","count":1},{"id":"GO:0007455","count":1},{"id":"GO:0003139","count":1}]},{"hash":"2218201128424147591","title":"Developmental Adhesion and Morphogenesis","description":"This cluster centers on processes involved in tissue development and remodeling, including cell adhesion, apical constriction, end-bud growth, myoblast proliferation, and trophoblast differentiation, with plasminogen activation hinting at extracellular remodeling. While a few terms (like vitellogenesis and cytokine regulation) are more peripheral, the common theme appears to be developmental morphogenesis across diverse tissues. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0007296","count":2},{"id":"GO:0007268","count":2},{"id":"GO:0032733","count":1},{"id":"GO:0003383","count":1}]},{"hash":"1429638026109957509","title":"GPCR-Mediated Stress Signaling","description":"This cluster centers on cellular responses to multiple stimuli (temperature, hypoxia, prostaglandin E) and GPCR-related signaling. Key terms include cellular response to temperature, hypoxia, prostaglandin signaling, GPCR internalization, and Rho-mediated pathways, with additional tissue-context terms such as heart development and thermogenesis that reflect downstream roles. Together they suggest a set of proteins involved in stimulus-triggered signaling, particularly GPCR-driven cascades, rather than a single metabolic function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0097050","count":3}]},{"hash":"1300400803941943610","title":"Unknown","description":"The GO terms are highly diverse, including chloroplast/light-response terms, mitochondrial targeting, spindle/centrosome processes, and various neuron-related localizations, with several obsolete terms. There is no coherent, shared function linking these proteins, so a reliable label cannot be assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009644","count":1},{"id":"GO:0009658","count":1},{"id":"GO:0051225","count":1},{"id":"GO:0007098","count":1},{"id":"GO:0006626","count":1}]},{"hash":"24286124725283233","title":"Innate Immune Signaling and Cytokine Regulation","description":"The cluster's top GO terms cluster around innate immune sensing and signaling (lipopolysaccharide response, TLR8 signaling, I-kappaB phosphorylation, and regulation of cytokine production), suggesting a core function in innate immune activation and cytokine regulation, despite a few unrelated terms present. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0046426","count":1},{"id":"GO:0090260","count":1},{"id":"GO:0086097","count":1},{"id":"GO:0007252","count":1}]},{"hash":"1513274758157953075","title":"DNA replication and repair","description":"The cluster is dominated by GO terms tied to DNA metabolism: mitochondrial, plastid, and viral DNA replication, plus multiple DNA repair processes (base-excision repair, alternative nonhomologous end joining, and gamma radiation response). A couple of terms (nervous system development, response to glucose) seem unrelated outliers. Overall, the proteins appear focused on genome maintenance and DNA synthesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0071333","count":1},{"id":"GO:0097681","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0006287","count":1}]},{"hash":"1751929212164067516","title":"Unknown","description":"The top GO terms span lipid metabolism, proteoglycan biosynthesis, proteolysis, immune response, and developmental signaling, with no single cohesive function tying most proteins together. This makes a confident, unified label difficult, so the cluster is best described as Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030210","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0051005","count":2},{"id":"GO:0070328","count":2},{"id":"GO:0044320","count":2}]},{"hash":"559661248411999646","title":"Vesicle Trafficking and Lipid Transport","description":"The top GO terms cluster around endomembrane processes (regulation of vacuole organization, ER exit, endosome localization) and lipid-related activities (phospholipid translocation, cholesterol storage, foam cell differentiation, protein palmitoleylation), suggesting a shared role in membrane trafficking coupled with lipid handling and modification. Confidence in this label is moderate because some terms are broad or organism-specific, but they coherently point to endomembrane transport and lipid regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044088","count":2},{"id":"GO:0010570","count":2},{"id":"GO:0070863","count":2},{"id":"GO:0036010","count":2},{"id":"GO:0006855","count":2}]},{"hash":"214512855604407612","title":"Mechanotransduction and Ca2+ signaling","description":"Enrichment centers on responses to mechanical stimulus, muscle stretch, regulation of SA node action potential, and release of sequestered calcium into the cytosol, all core to mechanosensitive signaling and excitation-contraction coupling in muscle and heart. Some inflammatory and skin-related terms appear but are less coherent with the main theme, suggesting the primary signal is mechanotransduction coupled to calcium dynamics.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":4},{"id":"GO:0010745","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0048265","count":4},{"id":"GO:0045083","count":4}]},{"hash":"78224110651887987","title":"RNA processing and ribosome biogenesis","description":"The top GO terms center on RNA processing and ribosome assembly\u2014positive regulation of mRNA splicing via spliceosome, regulatory ncRNA-mediated gene silencing, maturation of LSU-rRNA, and ribosomal large subunit biogenesis\u2014indicating a cohesive theme around RNA maturation and ribosome production. Additional terms for DNA replication, cell division, and development suggest broader cell-cycle and developmental roles that accompany these core processes but do not overshadow the primary RNA/ribosome focus.","confidence":"Medium","size":23,"edges":12,"triangles":4,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0000463","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0048701","count":3}]},{"hash":"543012303688769724","title":"Neural and sensory organ development","description":"The proteins show strong enrichment for neural and sensory development terms\u2014brain, midbrain, cerebellum, inner ear, and eye development\u2014along with motor neuron guidance and transcription regulation, suggesting a cohesive neurodevelopmental cluster.","confidence":"High","size":23,"edges":6,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0030901","count":12},{"id":"GO:0007626","count":12},{"id":"GO:0007420","count":12},{"id":"GO:0048839","count":12}]},{"hash":"330709778432524345","title":"Potassium and calcium ion transport and membrane potential regulation","description":"The cluster is dominated by GO terms for potassium ion homeostasis and transmembrane transport (import/export, stabilization of membrane potential) and by calcium ion transport/import, indicating a cohesive group of proteins that regulate ion gradients and membrane excitability. A few additional terms like pain perception and development are present but less central. Overall, the core theme is ion transport and membrane potential control.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":9},{"id":"GO:0097623","count":9},{"id":"GO:0030322","count":9},{"id":"GO:1990573","count":9},{"id":"GO:0019233","count":9}]},{"hash":"1606271237685548178","title":"Vascular immune coagulation and angiogenesis","description":"The cluster is enriched for immune-related activities (complement activation, adaptive immune response) and vascular/coagulation processes (blood coagulation, fibrin clot formation, vasoconstriction, angiogenesis, endothelial cell migration) with signaling linked to receptor tyrosine kinases and ERK cascade, suggesting a cohesive theme of immune-regulated vascular remodeling and coagulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":9},{"id":"GO:0007171","count":8},{"id":"GO:0045907","count":7},{"id":"GO:0002250","count":7},{"id":"GO:0072378","count":6}]},{"hash":"835716988689400576","title":"Redox Homeostasis and Oxidative Stress Response","description":"The cluster is enriched for GO terms tied to redox balance (cell redox homeostasis, oxidation-reduction processes, cellular oxidant detoxification) and oxidative stress response, suggesting proteins function together to manage cellular redox state and defend against oxidants. Additional terms like protein deglutathionylation support redox regulation, while other terms (methylamine metabolism, nucleotide biosynthesis, transcription regulation) may reflect broader metabolic context or incidental associations within the group. Overall, the dominant redox-focused signals point to a cohesive theme of maintaining redox homeostasis and responding to oxidative stress.","confidence":"High","size":23,"edges":250,"triangles":1711,"max_degree":22,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0045454","count":10},{"id":"GO:0055114","count":9},{"id":"GO:0098869","count":9},{"id":"GO:0030416","count":8},{"id":"GO:0003147","count":5}]},{"hash":"428261813823723424","title":"SNARE-Mediated Vesicle Exocytosis","description":"The top GO terms converge on regulated vesicle fusion: synaptic vesicle docking and priming, SNARE complex assembly, calcium-dependent exocytosis, and exocytic insertion events, spanning neuronal, endocrine, and gamete secretion (including insulin release and acrosome reaction). A few terms like cornified envelope assembly are peripheral, but the dominant theme is SNARE-driven vesicle trafficking and secretion across tissues.","confidence":"High","size":23,"edges":62,"triangles":80,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0016081","count":3},{"id":"GO:0055010","count":2},{"id":"GO:0010807","count":2},{"id":"GO:2000010","count":2},{"id":"GO:0098967","count":2}]},{"hash":"55056924523030850","title":"Cell signaling and stress responses","description":"This cluster centers on diverse signaling and cellular response terms, including apoptotic processes, JNK cascade regulation, insulin signaling, and responses to various growth factors and stimuli, with some neuronal-context terms (excitatory postsynaptic potential, cerebellum development). The common thread is general cellular signaling and stress-response pathways rather than a single, cohesive pathway, so a broad label like this best captures the set.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0006349","count":4},{"id":"GO:1903833","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0021549","count":3}]},{"hash":"312146579015566283","title":"Pattern-recognition receptor signaling and cytokine production","description":"The cluster is dominated by GO terms tied to innate immune sensing of microbial components (LPS/TLR4 signaling, muramyl dipeptide detection, dsRNA response) and the resulting cytokine production (IL-8, IL-1\u03b2), with an additional link to xenophagy. This suggests a cohesive theme of PRR-mediated detection and inflammatory signaling, along with antimicrobial autophagy.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002830","count":2},{"id":"GO:0042228","count":2},{"id":"GO:1904417","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0032498","count":2}]},{"hash":"513801858632401597","title":"Epithelial polarity and vesicle trafficking","description":"The cluster shows strong representation of epithelial cell polarity terms (apical/basal polarity, tight junction assembly) along with vesicle trafficking pathways (ER-Golgi transport, COPII regulation) and microtubule organization (tubulin complex assembly), indicating a cohesive function in establishing polarity and coordinating secretory/trafficking processes in epithelial cells. Some brain development and apoptotic process terms may be incidental rather than defining the cluster.","confidence":"High","size":23,"edges":115,"triangles":169,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0034629","count":4},{"id":"GO:0070830","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0007420","count":4}]},{"hash":"1060045408884562033","title":"Unknown","description":"The top GO terms span endosome-lysosome transport, multiple differentiation programs (muscle, germinal center, pro-T cells), immune regulation, and various transport and morphogenesis processes, with no clear, single shared function linking the proteins. The lack of edges and a cohesive theme suggests the cluster does not reflect one specific pathway, so Unknown is most appropriate.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":2},{"id":"GO:0035914","count":2},{"id":"GO:1904431","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0032764","count":2}]},{"hash":"1179170152746143911","title":"Bone and cartilage development","description":"This cluster is dominated by GO terms for ossification and cartilage condensation, with positive regulation of BMP signaling, which are central to skeletal development. Although some terms touch other organs, the strongest co-occurrence points to bone/cartilage formation and BMP-mediated regulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0030513","count":4},{"id":"GO:0007156","count":3},{"id":"GO:0007157","count":3}]},{"hash":"1008293045759300980","title":"Metanephric kidney development and innate immunity","description":"This cluster shows a mix of kidney development terms (metanephric ascending thin limb development, metanephric proximal tubule development, mesonephric duct development) alongside innate immune terms (complement activation lectin pathway, phagocytosis recognition, basophil activation, response to fungal molecules, NK cell chemotaxis regulation). The combination suggests proteins with roles in both kidney organogenesis and immune signaling, or annotations spanning these areas, hence a label capturing both themes. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":15},{"id":"GO:0006910","count":9},{"id":"GO:0072218","count":9},{"id":"GO:0045575","count":9},{"id":"GO:0071226","count":9}]},{"hash":"617557380314824069","title":"Vacuolar amino acid transport","description":"The GO terms cluster around movement of specific amino acids across the vacuolar membrane (e.g., serine, alanine, proline, histidine) and related nutrient-starvation responses, indicating a group of proteins that primarily function in vacuolar amino acid transport and homeostasis.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090516","count":1},{"id":"GO:0090452","count":1},{"id":"GO:0015808","count":1},{"id":"GO:0015824","count":1},{"id":"GO:1901481","count":1}]},{"hash":"1978590199327837701","title":"Neuronal signaling and brain development","description":"GO terms indicate strong emphasis on chemical synaptic transmission, neurotransmitter secretion (GABA and glutamate), and signaling (JUN phosphorylation), alongside brain development processes (angiogenesis and lateral ventricle development). While some general cellular processes appear, the dominant theme is neuronal communication during brain development, justifying this label as a concise representation of the cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":2},{"id":"GO:0014051","count":2},{"id":"GO:0007268","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0014047","count":2}]},{"hash":"1627249779862171935","title":"Hormone and Stress Response Signaling","description":"The top GO terms point to hormonal and stress-related responses (response to dexamethasone, vitamin D) and mechanical stimuli, with associated regulation of transcription and signaling (e.g., PI3K/AKT). Some terms also touch on adipogenesis, liver regeneration, and immune-related processes, suggesting a broad hormone/stress-responsive program rather than a single specific function. Therefore, the label reflects a general theme of hormonal and stress signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051898","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0061408","count":2}]},{"hash":"292097794258886468","title":"Unknown","description":"The top GO terms cover immune signaling (B cell receptor signaling and B cell proliferation), protein turnover (ubiquitin-proteasome pathways), mitochondrial fission, mechanotransduction, collagen fibril organization, and neuron development (axonogenesis). The terms are diverse with no single unifying function or pathway evident, and there are no network edges to reinforce a common role. Therefore, a coherent, specific label cannot be assigned.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0032436","count":3},{"id":"GO:0090141","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0050853","count":3}]},{"hash":"1321843982069663996","title":"Actin cytoskeleton remodeling and cell polarity","description":"This cluster is dominated by terms tied to actin cytoskeleton organization and remodeling (sarcomere organization, actin crosslink formation, microspike assembly, actin cortical patch localization) and by polarity-related signaling (Rho regulation, cell shape/polarity maintenance, Wnt signaling). Together these suggest a cohesive group of proteins that coordinate actin dynamics, cell shape, and polarity, with signaling inputs from Rho and Wnt pathways. A few terms (like IL-2 production) are less central but may reflect downstream immune signaling contexts.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045214","count":6},{"id":"GO:0035023","count":5},{"id":"GO:1900042","count":4},{"id":"GO:0071963","count":3},{"id":"GO:0031532","count":3}]},{"hash":"988550966480224220","title":"Immune and developmental signaling","description":"The top GO terms span innate immune response and Fc-epsilon receptor signaling, lymphoid differentiation, and broad developmental processes such as BMP signaling, skeletal morphogenesis, salivary gland branching, and synapse assembly, suggesting a set of proteins involved in signaling networks that bridge immune functions and development rather than a single narrow function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0002320","count":2},{"id":"GO:0060445","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0038095","count":2}]},{"hash":"891308119857797362","title":"Angiogenesis and Immune Regulation","description":"The cluster is enriched for angiogenesis and renin-angiotensin system terms, plus adaptive immune and antigen-processing processes, suggesting coordination between vascular development and immune signaling.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0019885","count":5},{"id":"GO:0030154","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0007275","count":3}]},{"hash":"687820983631655537","title":"Innate Immune Signaling and Cytokine Regulation","description":"This cluster is enriched for innate immune pathways and cytokine control: TLR8 signaling, LPS-mediated signaling, NF-kB (I-kappaB phosphorylation), and regulation of interferon and other cytokines, along with JAK-STAT regulation. While a couple of terms (collagen fibril organization, Wnt signalosome assembly) are less directly tied to immunity, the dominant theme is immune signaling and cytokine modulation. Confidence: Medium.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0046426","count":1},{"id":"GO:0090260","count":1},{"id":"GO:0007252","count":1},{"id":"GO:0034158","count":1}]},{"hash":"610349511950257260","title":"Drosophila Developmental Signaling","description":"This cluster\u2019s GO terms cover multiple signaling and developmental processes in Drosophila, including Ras and insulin signaling, imaginal disc fusion, tracheal tube length regulation, lens development, and olfactory learning, suggesting a broad theme of insect development and signaling pathways rather than a single concrete function. Confidence: Medium","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008355","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0070307","count":1},{"id":"GO:0010748","count":1},{"id":"GO:0007016","count":1}]},{"hash":"1529507519842659893","title":"Unknown","description":"The cluster shows GO terms spanning ER protein folding, pain perception, metabolism, fibrinolysis, extracellular matrix secretion, liver regeneration, proteolysis, and neural differentiation; there is no single cohesive function that ties these terms together for most proteins, so a specific label cannot be reliably assigned.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":3},{"id":"GO:0050968","count":2},{"id":"GO:0050966","count":2},{"id":"GO:0071333","count":1},{"id":"GO:0030070","count":1}]},{"hash":"802494328629839357","title":"Core Cellular Growth and Trafficking Machinery","description":"The top GO terms cluster around fundamental cellular processes such as cell cycle, cell division, and ribosome biogenesis, plus COPII vesicle budding for trafficking, which together reflect core machinery for growth and maintenance; other terms are supplementary developmental or structural processes, but no single specific pathway dominates.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0003341","count":2},{"id":"GO:0044829","count":2}]},{"hash":"2136847299256912412","title":"Proteasome-Dependent Ubiquitination and Cell Cycle Regulation","description":"These proteins are enriched for ubiquitin-mediated degradation, including SCF- and APC/C-dependent pathways, autoubiquitination, and K11/K48 linkages, plus cell-division processes. A DNA repair (NER) term also appears, which can be linked to ubiquitin signaling. The dominant theme is proteasome-driven proteolysis coordinating the cell cycle, making the label appropriate.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070911","count":22},{"id":"GO:0030433","count":22},{"id":"GO:0051865","count":22},{"id":"GO:0031146","count":19},{"id":"GO:0070979","count":19}]},{"hash":"548815977353333096","title":"Neurodevelopment and Growth Signaling","description":"This cluster centers on developmental processes, especially neurodevelopment (neuron migration, cerebral cortex regionalization, neuron survival) and endocrine growth regulation (growth hormone secretion, somatotropin cell development). Wnt signaling and GTPase regulation support patterning and signaling during development, with a few terms reflecting broader organogenesis (bone, digestive tract) that do not override the primary theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0060124","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0021796","count":2},{"id":"GO:0060133","count":2}]},{"hash":"1695307413940156389","title":"Embryonic Development and Morphogenesis","description":"The top GO terms point to processes across multiple tissues and organs (nervous system, lung mesenchyme, salivary gland morphogenesis, bone/ossification) and general development, adhesion, and tissue organization. This suggests a cohesive role in embryonic tissue formation and organogenesis, rather than a single pathway, hence a developmental/morphogenetic label.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0045162","count":2},{"id":"GO:0060484","count":2},{"id":"GO:0060665","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1847460002130433753","title":"Developmental gene regulation and chromatin remodeling","description":"The top GO terms center on transcriptional control in development (DNA-templated transcription, spleen and placenta morphogenesis) and chromatin-state modulation (histone acetylation/methylation, heterochromatin formation), with additional signals for ribosome biogenesis and rRNA processing that can accompany developmental gene expression programs.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0043984","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0006914","count":2}]},{"hash":"2003951497554221611","title":"Dopaminergic Visual Perception and Cocaine Response","description":"This cluster is dominated by GO terms referencing neural signaling, especially visual perception and learning, visual processing, dopaminergic synaptic transmission, and cocaine-related behavioral responses, all connected through ERK signaling and phosphorylation. Although other terms (e.g., heart development) appear, the core theme points to dopamine-mediated neural circuits underpinning vision and drug-related behaviors, suggesting a coherent neural signaling module.","confidence":"High","size":22,"edges":222,"triangles":1389,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":19},{"id":"GO:0008542","count":18},{"id":"GO:0007601","count":18},{"id":"GO:0048148","count":18},{"id":"GO:0071380","count":18}]},{"hash":"792358962147954856","title":"Unknown","description":"The top GO terms cover mRNA processing, pain stimulus detection, telomere-associated protein localization, actin bundle assembly, oligodendrocyte differentiation, chemokine production, skeletal muscle regeneration, dendrite development regulation, vitamin D response, and calcium transport. There is no clear shared function linking these terms, suggesting the proteins participate in multiple distinct processes or that the annotations are too diverse to define a cohesive theme. ","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006397","count":8},{"id":"GO:0050968","count":7},{"id":"GO:0070198","count":7},{"id":"GO:0051017","count":7},{"id":"GO:0048709","count":7}]},{"hash":"1826685431783877926","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1648018674093340761","title":"RNA processing and translation control","description":"This cluster centers on mRNA maturation and regulation (polyadenylation, splicing, poly(A) tail shortening) alongside translation initiation control (eIF4F complex assembly, translational initiation, IRES-dependent initiation), suggesting a coordinated module that links RNA processing to translation, potentially active under stress.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":14},{"id":"GO:0045292","count":14},{"id":"GO:0010610","count":13},{"id":"GO:1901407","count":12},{"id":"GO:0097010","count":11}]},{"hash":"1603008334969988584","title":"Pain and Inflammation with Vascular Tone Regulation","description":"The cluster is dominated by nociception and inflammatory signals (sensory perception of pain, inflammatory response, LPS response) alongside vascular-related processes (blood coagulation, vasoconstriction). The presence of GPCR signaling and temperature/metabolic terms (thermogenesis, electron transport chain) suggests a coordinated program linking immune and vascular responses with energy metabolism.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0006954","count":15},{"id":"GO:0045986","count":15},{"id":"GO:0032496","count":15},{"id":"GO:0007596","count":15}]},{"hash":"371476625672486647","title":"Hippo/Wnt Growth Control and Apoptosis","description":"These proteins are enriched for Hippo signaling and regulation of canonical Wnt signaling, as well as negative regulation of cell proliferation and apoptotic processes, indicating a core role in growth control and the balance between proliferation and cell death. While other terms (e.g., potassium transport, keratinocyte differentiation, and neural signaling like excitatory postsynaptic potentials and visual learning) suggest tissue-specific roles, the central theme across the cluster appears to be growth regulation through Hippo and Wnt pathways.","confidence":"High","size":22,"edges":24,"triangles":10,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060044","count":13},{"id":"GO:0030216","count":13},{"id":"GO:0035329","count":13},{"id":"GO:0006915","count":13},{"id":"GO:0006813","count":13}]},{"hash":"1691416141620202909","title":"Chromatin organization and transcription regulation","description":"The top GO terms cluster around chromatin structure and transcription control: nucleosome assembly, pericentric and silent mating-type cassette heterochromatin formation, DNA-templated transcription and RNAP II\u2013associated regulation, and preinitiation complex assembly. This pattern suggests a cohesive function centered on chromatin organization and transcriptional regulation, with a few terms like collagen catabolic process appearing as outliers. Overall, the cluster seems to reflect chromatin maintenance coupled with transcriptional control mechanisms.","confidence":"Medium","size":22,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030574","count":2},{"id":"GO:0010801","count":2},{"id":"GO:0030307","count":2},{"id":"GO:0032968","count":1},{"id":"GO:0006334","count":1}]},{"hash":"855082430177839715","title":"Chromatin organization and histone modification","description":"This cluster is centered on chromatin-related processes: nucleosome assembly, heterochromatin organization, and establishment of protein localization to chromatin, with histone methylation marks (H3-K27, H3-K4). Some terms are obsolete, but collectively they point to chromatin structure and epigenetic regulation; nuclear protein quality control terms reflect the shared nuclear context as well.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":1},{"id":"GO:0070828","count":1},{"id":"GO:0006334","count":1},{"id":"GO:0098532","count":1},{"id":"GO:0016584","count":1}]},{"hash":"808123689185622493","title":"Synaptic vesicle trafficking and Golgi transport","description":"The terms cluster around vesicle movement and docking across Golgi, ER, endosomes, and plasma membrane, with processes like vesicle tethering, exocytosis, and synapse assembly, suggesting coordinated neuronal vesicle trafficking and synaptic formation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":1},{"id":"GO:0007166","count":1},{"id":"GO:0051965","count":1},{"id":"GO:0048278","count":1},{"id":"GO:0030242","count":1}]},{"hash":"978064561113700180","title":"Mitochondrial Transport and Dynamics","description":"The cluster centers on mitochondrial processes: regulation of membrane permeability, mitochondrial membrane fission, and various transmembrane transport activities (ADP and ornithine), pointing to energy metabolism and organelle dynamics. While a few terms touch on broader signaling (IGF response, EMT, pregnancy), these appear peripheral to the core theme of mitochondrial transport and remodeling.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007565","count":3},{"id":"GO:0048168","count":2},{"id":"GO:0016540","count":2},{"id":"GO:0001837","count":2},{"id":"GO:1990314","count":2}]},{"hash":"1022633822954450178","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035973","count":2},{"id":"GO:0039702","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0030260","count":2}]},{"hash":"1984560458969182896","title":"Membrane transporters and synaptic vesicle loading","description":"This cluster centers on transmembrane transport of ions and small molecules (potassium, nitrate, sugars, vitamins) and includes neuronal-related processes such as synapse assembly and neurotransmitter loading into synaptic vesicles, indicating a cohesive theme of membrane transport with a synaptic vesicle function group.","confidence":"Medium","size":22,"edges":57,"triangles":36,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0007416","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0006004","count":3},{"id":"GO:0042891","count":3}]},{"hash":"1155024258029862956","title":"Neural and inner ear development","description":"This cluster is dominated by GO terms related to nervous system formation and sensory organ development, including neural tube closure, cochlea and inner ear receptor cell development, and sympathetic ganglion development. A calcium transport term also aligns with neuronal signaling, supporting a neural/sensory morphogenesis theme, though a few terms touch broader embryonic processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042733","count":2},{"id":"GO:0090103","count":2},{"id":"GO:0090179","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0098703","count":2}]},{"hash":"1457641614459880051","title":"Neuroimmune signaling and development","description":"Top GO terms cluster around innate immune responses (interferon-beta production, LPS signaling, defense against Gram-positive bacteria) and neural development (axonogenesis, corpus callosum development), with additional signals for dopamine response and angiogenesis. This suggests a theme of neuroimmune communication intersecting with developmental processes, though broader pathways like PI3K signaling add some heterogeneity.","confidence":"Low","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045359","count":16},{"id":"GO:0007409","count":16},{"id":"GO:0022038","count":16},{"id":"GO:0050830","count":16},{"id":"GO:0031663","count":16}]},{"hash":"2167347363412823046","title":"Membrane Transport and Osmotic Stress Response","description":"The cluster shows enrichment for transmembrane transport and nutrient/ion handling, with multiple GO terms pointing to ion and vitamin transport (potassium ion transmembrane transport, dehydroascorbic acid transport, vitamin transmembrane transport), as well as sugar-related transport (fructose stimulus) and osmotic stress response. The presence of a vesicular trafficking term (neurotransmitter loading into synaptic vesicle) suggests involvement in vesicle-mediated transport as part of cellular homeostasis. A weaker, unrelated term (cellular response to interleukin-4) may reflect annotation noise. Overall, the common theme ties to membrane transport and osmotic/nutrient homeostasis, including vesicular processes.","confidence":"Medium","size":22,"edges":72,"triangles":27,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0071353","count":2},{"id":"GO:0042149","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0070837","count":2}]},{"hash":"2040336049213626100","title":"Cell signaling and cytoskeletal remodeling","description":"The cluster centers on multiple receptor- and small GTPase-mediated signaling pathways (T cell receptor, EGFR, ephrin receptor signaling) that converge on actin cytoskeleton dynamics (actin filament branching, podosome assembly). This points to a cohesive theme of signal transduction driving cytoskeletal remodeling and cell adhesion/migration, with a few terms related to development and xenobiotic response likely reflecting broader roles of these pathways.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0007264","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0048013","count":4},{"id":"GO:0035690","count":4}]},{"hash":"482324394558806074","title":"T Cell Receptor Signaling Modulators","description":"The top GO terms include negative and positive regulation of T cell receptor signaling, along with interferon response and IL-18 production, pointing to proteins that modulate TCR signaling and broader immune activation. Additional terms on transcription elongation and mRNA stability suggest linked regulation of gene expression in immune cells, with ER-related terms possibly reflecting protein processing in activated cells. Overall, the cluster centers on modulation of T cell signaling and immune responses.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0043488","count":2},{"id":"GO:0090502","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1567192924452312909","title":"Unknown","description":"The proteins exhibit diverse GO terms, including endocytosis and iron transport, alongside transcription regulation and cell cycle processes, with no single shared function dominating.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034244","count":2},{"id":"GO:0010972","count":2},{"id":"GO:0007070","count":1},{"id":"GO:0006898","count":1},{"id":"GO:0006760","count":1}]},{"hash":"1909314337809113314","title":"DNA Repair and Stress Response","description":"The cluster is dominated by DNA maintenance processes (DNA recombination, base-excision repair) and RNA stability regulation, with supporting signals of cellular stress responses (response to xenobiotic stimulus, redox homeostasis). Although some terms are tissue-specific or archaic, the strongest and most consistent themes point to genome maintenance and general stress adaptation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0090502","count":7},{"id":"GO:0042493","count":7},{"id":"GO:0045454","count":6},{"id":"GO:0014912","count":6}]},{"hash":"424439655185282629","title":"Unknown","description":"The top terms are a mix: Hedgehog signaling (smoothened), kidney development, chromatin-related processes (nucleosome assembly, histone exchange, regulation of chromatin assembly), a tRNA modification term, and several obsolete terms. With no connecting edges or coherent single theme, there isn\u2019t a clear, representative function for this cluster. ","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0006334","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0010847","count":1}]},{"hash":"894124077313372001","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":28,"triangles":4,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":2},{"id":"GO:0042551","count":2},{"id":"GO:0000350","count":1},{"id":"GO:0000389","count":1},{"id":"GO:0048671","count":1}]},{"hash":"1083152297264308549","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":132,"triangles":399,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":9},{"id":"GO:0035278","count":9},{"id":"GO:1905000","count":8},{"id":"GO:0030036","count":8},{"id":"GO:0048235","count":8}]},{"hash":"1062964948255275705","title":"Developmental signaling and synapse organization","description":"The cluster centers on synapse organization and neuronal plasticity, with supporting developmental processes such as angiogenesis, kidney development, and genital morphogenesis, plus multiple signaling pathways (Rho, PI3K, guanylyl cyclase). This suggests a theme of signaling-driven development affecting neural structure and function, rather than a single, narrow pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050808","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0014068","count":3}]},{"hash":"1930851877558459131","title":"Mitochondrial Transport and Membrane Potential Regulation","description":"The cluster is dominated by mitochondrial-focused GO terms: genome maintenance, apoptotic mitochondrial changes, regulation of membrane permeability and membrane potential, and transmembrane transport of metabolites such as CoA and NAD. Additional terms reference oxidative stress response and metabolism signaling, supporting a shared theme of mitochondrial transport and energy/redox regulation, with some links to broader metabolic states (e.g., IGF signaling and liver regeneration). Overall, these proteins appear to form a module centered on mitochondrial transport and membrane potential control.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":4},{"id":"GO:0008637","count":4},{"id":"GO:0097421","count":4},{"id":"GO:0046902","count":4},{"id":"GO:0006843","count":4}]},{"hash":"2229960422454632324","title":"Spermatid chromatin remodeling","description":"The cluster centers on nucleosome assembly and histone modifications, including spermatid nucleus differentiation, which together point to epigenetic regulation during spermatogenesis. While a few terms touch on signaling or drug response, the strongest and most representative theme is chromatin remodeling in spermatid development.","confidence":"High","size":22,"edges":12,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007289","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0006334","count":2},{"id":"GO:0061087","count":2},{"id":"GO:2001040","count":2}]},{"hash":"426623433037111612","title":"Rho-driven cell migration and epithelial polarity","description":"The top terms cluster around regulation of Rho signaling, establishment of apical/basal polarity, podosome assembly, and cell migration/attachment, all pointing to coordinated cytoskeletal remodeling and adhesion that drive cell movement and epithelial polarization. While a couple terms like B cell differentiation and STAT signaling appear less directly connected, the dominant theme is cytoskeletal signaling governing migration and polarity.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0045198","count":4},{"id":"GO:0071800","count":3},{"id":"GO:0006931","count":3},{"id":"GO:0002315","count":3}]},{"hash":"252522543347505728","title":"DNA-Templated Transcription Regulators","description":"Most enriched GO terms are about DNA-templated transcription and regulation of transcription by RNA polymerase II, which points to a cluster dominated by transcriptional regulators. A few terms (tRNA biosynthesis, dendrite development, endothelial cell migration) are less cohesive with this theme, suggesting some functional noise or multi-function proteins. Overall, the label captures the core function of the cluster.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0008616","count":1},{"id":"GO:0101030","count":1},{"id":"GO:0043535","count":1}]},{"hash":"729397611456695825","title":"Telomere maintenance and telomerase regulation","description":"The top GO terms are dominated by telomere-related processes\u2014telomere maintenance, lengthening, assembly, and localization to chromosome telomeres\u2014with several entries describing negative regulation of telomerase activity or telomere maintenance. This points to a cohesive cluster of proteins involved in telomere biology and its regulation; only one term appears unrelated (epithelial cell proliferation), but the overall theme is clearly telomere maintenance.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050680","count":1},{"id":"GO:0032206","count":1},{"id":"GO:0010833","count":1},{"id":"GO:0070198","count":1},{"id":"GO:0051974","count":1}]},{"hash":"146965751181426331","title":"B cell signaling and lymphoid development","description":"The cluster is enriched for B cell receptor signaling, plus downstream signaling like NF-kappaB, ERK, and PI3K pathways, indicating a core immune signaling theme. Related terms like thymus development and endothelial cell migration/angiogenesis suggest a broader lymphoid development context with vascular involvement. While some terms are obsolete, the dominant pattern points to immune receptor signaling linked to lymphoid organ development. Overall, the label captures the central immune signaling and developmental aspects of the cluster.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0043552","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0070374","count":3}]},{"hash":"824974127006759241","title":"Unknown","description":"These proteins show a mix of processes, including transmembrane transport (vitamins, taurine, xenobiotics), RNA splicing and stability regulation, plant hormone signaling, photosynthesis, and various metabolism/development terms. There is no single dominant function tying all members together, and the cluster has no edges or triangles, indicating a lack of functional cohesion. Therefore, I cannot assign a specific, representative label.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042891","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015734","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0000398","count":3}]},{"hash":"1261412101174074568","title":"Ubiquitin-Dependent Degradation and NF-kB Regulation","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes with multiple ubiquitin chain types (K48, K63, K6), autoubiquitination, and ERAD, along with positive regulation of NF-kB signaling and TNF-mediated pathways. This points to a cohesive set of proteins involved in ubiquitin-mediated proteolysis and its role in inflammatory signaling. The presence of histone catabolism is a potential ancillary connection, but overall the group centers on ubiquitin-driven protein turnover and NF-kB regulation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0051865","count":10},{"id":"GO:0070534","count":8},{"id":"GO:0085020","count":8},{"id":"GO:0030433","count":8}]},{"hash":"753540644234943254","title":"Multisystem Development and Differentiation","description":"The set includes neural development (Purkinje cell layer development) and learning-related terms, tissue remodeling and wound healing (angiogenesis in wound healing, epithelial proliferation), lactation-related processes (lactose biosynthetic process, mammary gland involution), and reproductive/developmental terms (zona pellucida penetration, development of secondary sexual characteristics). This spread suggests a broad theme of developmental and morphogenetic programs across multiple tissues rather than a single specific pathway. The fit is plausible but not tight, so I\u2019d rate the confidence as Medium.","confidence":"Medium","size":22,"edges":56,"triangles":29,"max_degree":10,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":6},{"id":"GO:0006486","count":5},{"id":"GO:0021680","count":4},{"id":"GO:0060055","count":4},{"id":"GO:0060054","count":4}]},{"hash":"942958820732895466","title":"Rho GTPase Signaling and Cytoskeletal Dynamics","description":"The cluster centers on small GTPase pathways (Rho/Ras) and regulators, with strong signals for lamellipodium assembly, cell migration, and adhesion-dependent spreading, indicating a cohesive role in cytoskeletal remodeling and motility. Immune signaling terms (IL-4/IL-7 responses, NK T cell differentiation) suggest additional cross-talk with immune function but do not override the core motility/cytoskeleton theme.","confidence":"High","size":22,"edges":16,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":18},{"id":"GO:0007264","count":16},{"id":"GO:0008286","count":16},{"id":"GO:0032633","count":16},{"id":"GO:1900026","count":16}]},{"hash":"518590473443571044","title":"Mitochondrial Metabolism and Insulin Signaling","description":"This cluster centers on mitochondrial function, with terms about membrane potential, transport of NAD, CoA, and citrate, as well as regulation of mitochondrial permeability, and links to insulin/IGF signaling and liver regeneration, suggesting a cohesive theme of mitochondrial regulation of metabolic signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":4},{"id":"GO:0000002","count":3},{"id":"GO:0008637","count":3},{"id":"GO:0097421","count":3},{"id":"GO:0046902","count":3}]},{"hash":"1587369208286414809","title":"Ciliary and Flagellar Axoneme Assembly and Motility","description":"These proteins cluster around the core structural and dynamic components of cilia/flagella: sperm axoneme and flagellum assembly, cilium movement, and regulation of axoneme dynamics, including tubulin post-translational modifications (polyglycylation, polyglutamylation) and microtubule severing. The terms strongly point to a shared function in building and propelling cilia/flagella, especially in sperm, with a couple of outlier terms (L-arginine catabolic process, endothelial chemotaxis regulation) that are less connected to this theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007288","count":2},{"id":"GO:0018094","count":2},{"id":"GO:0051013","count":2},{"id":"GO:1905419","count":2},{"id":"GO:0018095","count":2}]},{"hash":"1291433284643985266","title":"Organ development and angiogenesis signaling","description":"The GO terms cluster around organogenesis: heart development, kidney development, and angiogenesis are prominent; vascular-related signaling (smoothened pathway, NO biosynthesis) and mechanical stimulus responses also fit vascular/organ development contexts. Despite no edges, the shared terms point to a developmental, vascular-program theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000338","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0014068","count":2}]},{"hash":"2205050975520363","title":"Genome maintenance and cell cycle","description":"The top GO terms cluster around nuclear processes essential for genome integrity and progression through the cell cycle: DNA replication, double-strand break repair via homologous recombination, mitotic sister chromatid cohesion, meiotic cell cycle, and protein ubiquitination. While there are some development-related terms, the dominant signal points to genome maintenance and cell-cycle regulation, making this label a reasonable summary of the cluster.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0071260","count":3}]},{"hash":"2261714108167881060","title":"Innate Antiviral Defense","description":"Based on the top GO terms, the cluster is enriched for antiviral defense and innate immune signaling (defense response to virus, innate immune response, TLR8 signaling, I-kappaB phosphorylation, interferon production), indicating a cohesive antiviral innate immune function. The collagen fibril organization and axonogenesis terms appear as ancillary signals, but do not outweigh the antiviral/immunoregulatory theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051607","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0046426","count":3}]},{"hash":"1260787045989767157","title":"Axon guidance and synapse assembly","description":"This cluster\u2019s GO terms converge on neural development and connectivity: corpus callosum development, axonal fasciculation, axon regeneration regulation, and positive regulation of synapse assembly indicate a module involved in neural wiring and synapse formation. Keratan sulfate proteoglycan biosynthesis suggests extracellular matrix components that support neural tissue organization, while apoptotic and dephosphorylation processes reflect broader regulatory mechanisms during development. Overall, the cluster appears to represent neural development and connectivity functions.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018146","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0008285","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0048681","count":2}]},{"hash":"914665505973214119","title":"Planar polarity signaling and neural axon guidance","description":"The GO terms point to planar polarity signaling and neuronal axon guidance, with linked morphogenesis processes like lung branching and angiogenesis, indicating a cluster of PCP components that also influence neural connectivity.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048105","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0090251","count":2},{"id":"GO:0060490","count":2},{"id":"GO:0001525","count":2}]},{"hash":"117769991316752395","title":"Embryonic Development Signaling and Angiogenesis","description":"The terms reflect embryonic morphogenesis of cranial structures, angiogenesis, signaling pathways (ERK cascade, Kit, growth hormone receptor), and neuron development, indicating a cluster of proteins involved in developmental signal transduction and vascular/neuronal morphogenesis. The presence of angiogenic and growth-factor signaling terms suggests a cohesive module rather than disparate processes.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0042503","count":2},{"id":"GO:0031532","count":2}]},{"hash":"1348314831731846316","title":"Cardiac morphogenesis with transcriptional regulation","description":"The top GO terms highlight cardiac development (outflow tract septum morphogenesis, cardiac muscle cell proliferation) and transcriptional regulation (DNA-templated transcription, negative regulation of transcription by RNA Pol II, miRNA transcription), suggesting a cluster focused on heart morphogenesis governed by transcriptional control. Some pancreas and lung morphogenesis terms appear but are secondary.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0061113","count":3},{"id":"GO:0000122","count":3},{"id":"GO:1902894","count":3},{"id":"GO:1901522","count":3}]},{"hash":"927967243613406329","title":"Chromatin Regulation and Transcription","description":"The top terms cluster around histone modification (H4-K16 acetylation, histone deacetylation, histone displacement) and DNA-templated transcription, indicating chromatin remodeling and transcription control as the core function. Some development-related terms may reflect downstream roles of transcriptional regulators, but the common theme is regulation of gene expression via chromatin state.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001207","count":2},{"id":"GO:0043984","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0016575","count":2}]},{"hash":"16631105773757640","title":"Hypoxia-linked tissue remodeling and immune signaling","description":"This cluster shows GO terms tied to hypoxia response, tissue differentiation, ECM remodeling and cell adhesion, plus immune activation (T cell activation) and ubiquitin-dependent protein turnover. The combination points to processes where hypoxic stress drives tissue remodeling and interacts with immune signaling and extracellular matrix dynamics, rather than a single narrow function. Therefore a name centered on hypoxia-driven remodeling with immune interactions best captures the shared theme.","confidence":"Medium","size":21,"edges":19,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":4},{"id":"GO:0007613","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0060528","count":4},{"id":"GO:0002291","count":3}]},{"hash":"1278551652328858735","title":"Calcium-NFAT signaling in neurons and muscle","description":"The top GO terms center on calcium-dependent signaling at postsynaptic sites (excitatory postsynaptic potential, regulation of postsynaptic calcium), and the calcineurin-NFAT pathway, plus muscle-related processes (regulation of muscle filament sliding speed, cardiac muscle hypertrophy). This points to a shared signaling axis governing neural activity and muscle adaptation, with additional neural developmental terms (astrocyte differentiation, photoreceptor morphogenesis) reflecting broader roles of these pathways in neural tissue development. Overall, they cohere around calcium/NFAT-mediated signaling in neural and muscular contexts.","confidence":"High","size":21,"edges":121,"triangles":390,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032972","count":17},{"id":"GO:0042994","count":17},{"id":"GO:0014898","count":17},{"id":"GO:0048708","count":17},{"id":"GO:0008594","count":17}]},{"hash":"543348687152696640","title":"Developmental Patterning and Organogenesis","description":"The GO terms point to broad embryonic development and body patterning across multiple tissues (primitive streak, anterior/posterior specification, forebrain/midbrain development, heart development, uterus, spleen) along with neural differentiation (PNS neurons, GABAergic interneurons). The inclusion of transcriptional regulation suggests coordinated control of gene expression during these developmental processes, justifying a label focused on developmental patterning and organogenesis.","confidence":"Medium","size":21,"edges":5,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0090009","count":6},{"id":"GO:0048536","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0009952","count":6}]},{"hash":"1476682791042734126","title":"Bacterial membrane transporters and antibiotic response","description":"The GO terms are dominated by membrane-associated transport processes (vitamin and thiamine transport, branched-chain amino acid transport, phospholipid translocation, teichoic acid transport, long-chain fatty acid import) plus antibiotic-related responses (response to antibiotic, bacteriocin immunity). This pattern suggests a cluster of membrane transport proteins linked to bacterial stress/defense, with a note that teichoic acid transport hints at Gram-positive signaling. Overall, these themes cohesively point to membrane transport coupled with antibiotic response.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0015803","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0015888","count":2}]},{"hash":"407405813543606911","title":"Embryogenesis and tissue differentiation","description":"The GO terms cluster around embryonic development and differentiation across multiple tissues (cartilage morphogenesis, heart/placental development, endothelial and pancreatic lineages, left-right patterning, EMT in heart cushion formation), suggesting a general developmental program rather than a single tissue. A minor, non-specific term (mRNA splicing) appears incidental. ","confidence":"High","size":21,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2}]},{"hash":"1431893252422810751","title":"Ubiquitin-dependent proteolysis","description":"The Top Terms are dominated by ubiquitin-mediated processes (ubiquitin-dependent protein catabolic process, ERAD, autoubiquitination, and K48-linked ubiquitination), indicating a cluster centered on ubiquitin-proteasome degradation pathways. While a few terms touch on unrelated areas (peroxisome import, X chromosome dosage effects), the core signal is clear ubiquitin-dependent proteolysis. High","confidence":"","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0030433","count":10},{"id":"GO:0051865","count":10},{"id":"GO:1900095","count":8},{"id":"GO:0070936","count":8}]},{"hash":"2028160736023809537","title":"Skeletal development and cell adhesion","description":"Most terms cluster around cell-cell and cell-matrix adhesion (heterophilic adhesion, integrin-mediated adhesion) and skeletal/tissue formation (ossification in bone maturation, cartilage condensation, metanephric limb development). This suggests the proteins are enriched for roles in skeletal development and cohesive cell interactions during tissue formation. A few terms reference immune activation or neuronal synapse assembly, which may reflect broader developmental or annotation noise, but the dominant theme remains skeletal/adhesive processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0043931","count":5},{"id":"GO:0072218","count":5},{"id":"GO:0051965","count":4},{"id":"GO:0001502","count":4}]},{"hash":"1213539203762534126","title":"Dopaminergic Signaling and Vision","description":"In the cluster, top GO terms heavily feature GPCR and adenylate cyclase signaling, dopaminergic synaptic transmission, and visual processes (visual perception and learning), along with behavioral responses to cocaine and prostaglandin-related signaling. This pattern points to neuronal signaling networks governing dopamine-mediated reward and sensory processing, particularly vision. While some terms like electron transport and blood pressure regulation appear, the dominant theme is dopaminergic signaling linked to visual perception and cocaine responsiveness, giving a cohesive functional label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":20},{"id":"GO:0022900","count":20},{"id":"GO:0045777","count":20},{"id":"GO:0008542","count":19},{"id":"GO:0007190","count":19}]},{"hash":"98587531159043823","title":"Cellular stress response and apoptosis regulation","description":"The top GO terms point to responses to xenobiotic stimuli and peptide hormones, coupled with apoptosis, redox balance, and regulation of mRNA stability\u2014together suggesting a theme of cellular stress response with gene expression control. Some terms like corneocyte development or aging appear less core to this cluster, but the dominant signals are stress response and regulation of survival pathways. The cluster appears sparsely connected (one edge), supporting a broad, multi-function stress/regulatory module rather than a single cohesive pathway.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042493","count":7},{"id":"GO:0071375","count":7},{"id":"GO:0006915","count":7},{"id":"GO:0006310","count":7},{"id":"GO:0090502","count":7}]},{"hash":"1310692088876487881","title":"Unknown","description":"The top GO terms are very diverse, spanning blood coagulation, immune response to lipopolysaccharide, growth factor signaling, epithelial/hair cell differentiation, and neural/axonal guidance processes. There is no single dominant function tying these terms together, suggesting the cluster captures several unrelated biological themes rather than a cohesive module. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0019233","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0048012","count":2},{"id":"GO:0030216","count":2}]},{"hash":"126312665439319174","title":"Neuronal dendrite morphogenesis and axon guidance","description":"These proteins cluster around neural development and connectivity, with multiple terms for dendrite formation, spine morphogenesis, axonogenesis, and axon fasciculation, plus adhesion and SHH signaling. A few outliers are obsolete or unrelated, but the prevailing theme is neuronal morphogenesis and connectivity.","confidence":"High","size":21,"edges":207,"triangles":1275,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060997","count":10},{"id":"GO:1902960","count":8},{"id":"GO:1902955","count":8},{"id":"GO:1905240","count":8},{"id":"GO:0007156","count":8}]},{"hash":"892593535758901050","title":"Neuronal signaling and endocrine regulation","description":"The top GO terms point to neural activity-related processes (visual learning, excitatory postsynaptic potential, response to cocaine) alongside endocrine and growth regulation pathways (insulin receptor signaling, thyroid gland development, regulation of cell proliferation). This suggests a cluster of proteins involved in signaling that links neural activity with hormonal and growth regulatory processes, rather than a single narrow function.","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007100","count":21},{"id":"GO:0008542","count":20},{"id":"GO:0047484","count":20},{"id":"GO:0008285","count":20},{"id":"GO:0060079","count":20}]},{"hash":"974732711347264023","title":"Unknown","description":"This cluster mixes mitochondrial energy metabolism terms (oxidative phosphorylation, aerobic electron transport chain, proton transmembrane transport, complex IV assembly) with nuclear RNA processing/quality-control terms, and there are no connecting terms or interactions tying these functions together, so a single coherent theme cannot be inferred.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008535","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0019646","count":1},{"id":"GO:0006119","count":1},{"id":"GO:0071035","count":1}]},{"hash":"1432856515924924797","title":"Cell Cycle Regulation and Division","description":"The majority of terms point to cell cycle control (DNA-templated transcription for cycle gene expression, G1/S transition), cell division, and chromatid cohesion during meiosis, with both positive regulation of apoptosis and negative regulation of proliferation reinforcing a focus on cell-cycle decisions. Some peripheral terms about migration or immune signaling may reflect broader cellular responses but do not dominate the cluster\u2019s theme.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0006351","count":5},{"id":"GO:0051754","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0016477","count":4}]},{"hash":"715242928116309144","title":"Vesicle trafficking and receptor regulation","description":"Based on the GO terms, the cluster centers on vesicle trafficking (vesicle targeting from trans-Golgi to endosome) and receptor handling (negative regulation of receptor recycling), with supporting signals from G-protein complex assembly and regulation of protein turnover. This points to a cohesive theme of membrane trafficking coupled with modulation of signaling pathways, rather than a single enzymatic function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:0061084","count":1},{"id":"GO:0007329","count":1},{"id":"GO:0008616","count":1},{"id":"GO:2000059","count":1}]},{"hash":"17527405987514968","title":"Sensory perception and neural signaling","description":"The top GO terms cluster around sensory system functions (optic nerve morphogenesis, sensory perception of sound, detection of mechanical stimulus in sound) and neuronal communication (inhibitory postsynaptic potential, potassium ion transport), with supporting signals of locomotory behavior. Minor outliers like triglyceride catabolic process and amyloid regulation appear, but the dominant theme points to sensory processing and synaptic activity.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021631","count":5},{"id":"GO:0007605","count":5},{"id":"GO:0042220","count":5},{"id":"GO:0007626","count":5},{"id":"GO:0050910","count":5}]},{"hash":"1802910285619583051","title":"Neuronal development and synaptic vesicle regulation","description":"This cluster centers on GO terms related to brain development, neuronal signaling, and synaptic vesicle exocytosis/maturation, with supporting terms for intracellular transport and Rho signaling that govern neurite outgrowth and synaptic dynamics. The dominant signal is neural development and synaptic function, justifying a label focused on neuronal development and vesicle regulation.","confidence":"High","size":21,"edges":197,"triangles":1105,"max_degree":20,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0035023","count":6},{"id":"GO:2000300","count":5},{"id":"GO:0031384","count":5},{"id":"GO:0010796","count":5}]},{"hash":"1050470928931412877","title":"Cell signaling regulators","description":"Although several terms appear unrelated or marked obsolete, the strongest recurring theme is regulation of signaling pathways, including positive regulation of TGF-beta signaling, ERBB2 signaling, and interferon signaling, together with phosphorylation processes. This points to a cluster of proteins involved in modulating cellular signaling rather than a single, cohesive pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007268","count":2},{"id":"GO:0030511","count":2},{"id":"GO:1904251","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0015937","count":1}]},{"hash":"2290332678369930652","title":"Unknown","description":"GO terms are too diverse to reveal a single cohesive function; the cluster mixes developmental processes across tissues with xenobiotic and plant hormone biosynthesis, suggesting no clear common theme.","confidence":"","size":21,"edges":11,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":9},{"id":"GO:0008585","count":9},{"id":"GO:0046232","count":9},{"id":"GO:0035902","count":9},{"id":"GO:0061298","count":8}]},{"hash":"969496789126499156","title":"Neural development and signaling regulation","description":"The proteins in this cluster are enriched for central nervous system development and response to morphine, along with regulation of key signaling pathways (Wnt, activin), and associated differentiation and morphogenesis processes (muscle differentiation, endothelial migration, hematopoietic differentiation). This suggests a cohesive theme around developmental signaling with a neural-development emphasis, rather than a single specific function.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":2},{"id":"GO:0035414","count":1},{"id":"GO:0007417","count":1},{"id":"GO:0032926","count":1},{"id":"GO:0035914","count":1}]},{"hash":"2098910401736509821","title":"Rho GTPase\u2013driven actin remodeling and cell polarity","description":"The cluster shows strong enrichment for regulation of GTPase activity and regulation of Rho signaling, plus actin cytoskeleton\u2013related terms (mitotic contractile ring assembly, cortical actin localization) and cell polarity maintenance. This points to a cohesive theme of Rho-mediated actin dynamics governing cell shape and polarity, including cytokinesis-associated structures and GPCR-linked signaling that interfaces with Rho pathways; redox homeostasis appears as a secondary, supporting term. ","confidence":"High","size":21,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":4},{"id":"GO:0035023","count":4},{"id":"GO:1903475","count":3},{"id":"GO:0051666","count":3},{"id":"GO:0071963","count":3}]},{"hash":"590389363380695930","title":"Cerebellar glutamatergic synaptic transmission and LTD","description":"This cluster is dominated by GO terms for glutamatergic synaptic transmission and long-term synaptic depression, with support from cerebellar granule cell differentiation. The terms point to glutamatergic signaling and synaptic plasticity in cerebellar circuits, suggesting the proteins function together in cerebellar synaptic transmission and LTD. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0060316","count":1},{"id":"GO:0034968","count":1}]},{"hash":"276863231593299487","title":"Protein quality control and autophagy","description":"Terms cluster around protein quality control and degradation: chaperone activity, ubiquitin protease regulation, and autophagy/aggresome pathways, indicating a proteostasis-related cluster.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":1},{"id":"GO:1903007","count":1},{"id":"GO:0070389","count":1},{"id":"GO:0018279","count":1},{"id":"GO:0051131","count":1}]},{"hash":"1968900942633529445","title":"DNA repair and redox stress response","description":"The cluster is enriched for DNA repair functions (base-excision repair, DNA recombination) and stress-response processes (response to xenobiotics, redox/homeostasis), suggesting a theme around DNA damage response coupled to oxidative stress management. Some other terms appear peripheral or context-specific (mRNA stability regulation, signaling lipid processes, skin development).","confidence":"Medium","size":21,"edges":187,"triangles":954,"max_degree":20,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0007568","count":5},{"id":"GO:0006284","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0014912","count":4}]},{"hash":"1340869113764670917","title":"Ras/Rho GTPase signaling with actin dynamics","description":"The cluster is driven by GO terms centered on small GTPases (Ras, Rho) and their regulation, including positive regulation of GTPase activity and small GTPase-mediated signal transduction, plus actin filament bundle assembly. These point to a core theme of GTPase signaling controlling cytoskeletal remodeling, with neural and immune processes (synaptic plasticity, myelin maintenance, IL-4 production, NK cell regulation) reflecting downstream contexts. This combination supports a cohesive label focused on GTPase signaling and cytoskeletal dynamics.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007264","count":4},{"id":"GO:0032287","count":4}]},{"hash":"1725074259252484352","title":"Lymphocyte V(D)J Recombination","description":"The top GO terms are dominated by T cell receptor and immunoglobulin V(D)J recombination and pro-B cell differentiation, pointing to adaptive immune receptor rearrangement and lymphocyte development. While other terms reflect general cellular processes, the strongest signal centers on immune receptor assembly; thus the label captures the core theme but with some ambiguity due to support from non-immune terms. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033153","count":2},{"id":"GO:0033152","count":2},{"id":"GO:0002328","count":2},{"id":"GO:0046854","count":2},{"id":"GO:0070212","count":2}]},{"hash":"2229797998367451346","title":"Embryonic Craniofacial and Neural Development","description":"This cluster is dominated by GO terms for embryonic development, especially craniofacial/skelton morphogenesis and neural processes: neural crest cell migration, neuron migration, roof of mouth development, cartilage development, cochlea morphogenesis, organ induction, and metanephric mesenchyme development. The pattern indicates a cohesive role in early development of craniofacial and neural structures.","confidence":"High","size":21,"edges":31,"triangles":0,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":13},{"id":"GO:0021846","count":13},{"id":"GO:0060021","count":13},{"id":"GO:0090103","count":13},{"id":"GO:0001755","count":13}]},{"hash":"2183153723022258450","title":"Desmosomes, Adherens Junctions, and Membrane Trafficking","description":"The top GO terms cluster around cell\u2013cell adhesion structures (adherens junctions, desmosomes, hemidesmosomes) and their organization, plus protein localization to these junctions and Golgi-to-plasma-membrane transport. This, along with a few tissue-specific terms (keratinocytes, cardiac conduction), points to a group of proteins involved in junction assembly and delivery to the cell surface, relevant in epithelial and cardiac tissues. Overall, the theme is junction components and their membrane trafficking.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043001","count":2},{"id":"GO:0098911","count":1},{"id":"GO:0034332","count":1},{"id":"GO:0051548","count":1},{"id":"GO:0030216","count":1}]},{"hash":"1897942724462984365","title":"B cell receptor signaling and germinal center processes","description":"This cluster\u2019s top GO terms point to immune-related functions, notably B cell receptor signaling and germinal center formation. However, the list also includes diverse processes (transcription, tRNA processing, telomere maintenance, ion transport) and there are no edges linking proteins, indicating weak functional coherence. So the label captures the strongest signal but with limited confidence about a unified function.","confidence":"Low","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0031116","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0090342","count":1},{"id":"GO:0006351","count":1}]},{"hash":"1376299169165019020","title":"Actin Cytoskeleton Remodeling in Development","description":"This cluster is enriched for actin-related terms (actin cytoskeleton organization, actin crosslink formation, lamellipodium organization) plus developmental processes (dendrite development, glomerulus morphogenesis, glomerular basement membrane development), pointing to actin-driven morphogenesis across tissues.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032836","count":2},{"id":"GO:0051764","count":1},{"id":"GO:0030036","count":1},{"id":"GO:2000463","count":1},{"id":"GO:0031150","count":1}]},{"hash":"342343500121923239","title":"Unknown","description":"The top GO terms cover a wide range of unrelated processes\u2014from hormone signaling and apoptosis to DNA recombination, RNA metabolism, and various developmental and signaling pathways\u2014without a clear common function. The cluster has no edges, and several terms are obsolete, suggesting a heterogeneous set rather than a coherent functional group. Therefore no specific, representative label can be assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071375","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0090502","count":4},{"id":"GO:0045454","count":3}]},{"hash":"2020074633551434210","title":"Rho GTPase signaling and lamellipodium formation","description":"The top GO terms center on positive regulation of GTPase activity, regulation of Rho signaling, and lamellipodium assembly, all core to actin cytoskeleton remodeling and cell migration. Although some terms reference heart development or sensory perception, the strongest, consistently represented theme is Rho/GTPase-driven cytoskeletal dynamics that promote cell movement.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0030032","count":3}]},{"hash":"412141286752264031","title":"Unknown","description":"The GO terms are highly diverse, covering immune signaling (B cell receptor signaling, phagocytosis), microbial detection (peptidoglycan response), neural development (nervous system development, corticospinal neuron axon guidance), and organ development (kidney), plus structural/transport processes (sarcomere organization, sodium transport, cell junction localization). There isn\u2019t a single cohesive function that ties these proteins together, so a specific label cannot be confidently assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050853","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0001822","count":5},{"id":"GO:0010765","count":5},{"id":"GO:0045214","count":5}]},{"hash":"1708585602766210003","title":"Adherens junctions and epithelial polarity","description":"The top terms point to vesicle traffic and exocytosis, localization to adherens junctions, and maintenance of epithelial cell polarity and barriers, suggesting a cluster focused on cell-cell junctions and epithelial barrier organization. Some immune/sensory terms appear but do not override the core junctional/polarity theme. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006887","count":3},{"id":"GO:0045075","count":2},{"id":"GO:1901206","count":2},{"id":"GO:0071896","count":2},{"id":"GO:0006470","count":2}]},{"hash":"2053384381014663334","title":"Neural signaling and axonogenesis","description":"This cluster is enriched for neural-related functions: exocytosis regulation and calcium release point to neurotransmitter release and synaptic signaling; axonogenesis and visual perception suggest neural development and sensory system roles; Wnt-calcium signaling aligns with neuronal differentiation and signaling in the nervous system. The vascular terms are secondary and do not define the main theme. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045921","count":5},{"id":"GO:0007190","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0007409","count":4}]},{"hash":"1266457737879826417","title":"cAMP- and NFAT-mediated transcription signaling","description":"This cluster's top GO terms cluster around signaling cascades (cellular response to cAMP, growth hormone receptor signaling, regulation of calcineurin-NFAT signaling) that feed into transcriptional regulation (DNA-templated transcription and its regulation). Although there are a few metabolism and guard cell-related terms, the common thread appears to be signaling pathways that influence transcriptional activity, rather than a single metabolic process or structural function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006355","count":2}]},{"hash":"906018260526436592","title":"Cardiac potassium channels and conduction","description":"This cluster centers on GO terms related to cardiac electrophysiology, especially potassium ion transport and membrane processes that govern atrial action potential repolarization and heart rate regulation. The presence of membrane hyperpolarization and potassium import alongside atrial repolarization suggests a cohesive theme around potassium-channel\u2013mediated cardiac conduction, with occasional developmental terms likely reflecting broader roles of some proteins. Thus, a label focusing on cardiac potassium channels and conduction is appropriate.","confidence":"High","size":20,"edges":12,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":10},{"id":"GO:0043588","count":9},{"id":"GO:0051260","count":9},{"id":"GO:0098914","count":9},{"id":"GO:0071805","count":8}]},{"hash":"310700303411549488","title":"Protein Tyrosine Phosphatase Signaling","description":"GO terms emphasize tyrosine dephosphorylation and negative regulation of kinase activity, notably ERK1/ERK2 cascades and T cell receptor signaling. They also point to receptor-type protein tyrosine phosphatases at the cell surface and related signaling pathways, including insulin signaling. The common theme is phosphatase-mediated downregulation of tyrosine kinase\u2013driven signaling, justifying the label.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":19},{"id":"GO:0070373","count":19},{"id":"GO:0050860","count":19},{"id":"GO:1990264","count":15},{"id":"GO:0061097","count":15}]},{"hash":"456117892499856303","title":"Ribosome Biogenesis and rRNA Processing","description":"The top GO terms are centered on ribosome biogenesis, preribosome assembly, and maturation of LSU rRNA, with several entries on cytosolic ribosome assembly and rRNA/tRNA methylation, all pointing to RNA processing and ribosome assembly processes. A few items like transcription regulation and zinc transport are present but do not redefine the core function. Therefore, this label accurately reflects the dominant theme of ribosome production and RNA maturation in the cluster.","confidence":"High","size":20,"edges":121,"triangles":382,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:1902626","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0070475","count":2},{"id":"GO:0002127","count":2}]},{"hash":"800633388824540620","title":"Chromatin regulation and cell division machinery","description":"The top GO terms cluster around chromatin organization, histone modification, nuclear pore localization, and mitotic spindle assembly, suggesting the proteins mainly participate in chromatin regulation and mitotic/cell-cycle processes; other terms like ubiquitination and lysosome-related processes appear peripheral but do not dominate the set. ","confidence":"Medium","size":20,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0001845","count":3},{"id":"GO:0070262","count":2},{"id":"GO:0043966","count":2}]},{"hash":"1677092154710995679","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904251","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0015937","count":1},{"id":"GO:0070584","count":1},{"id":"GO:0061158","count":1}]},{"hash":"1087605243584864971","title":"Ion Transport and Neural Connectivity","description":"This cluster combines neural-related processes (regulation of grooming behavior, motor neuron axon guidance, cell-cell adhesion) with multiple ion transport activities (zinc, calcium, copper, sodium) and signaling at membranes (phospholipid dephosphorylation). While there is a cardiac signaling reference, the dominant theme is neural signaling supported by ion homeostasis, justifying a label focused on ion transport and neural connectivity.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:2000821","count":6},{"id":"GO:0008045","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0071577","count":5}]},{"hash":"1784401794880123105","title":"Neurodevelopment and Cardiac Morphogenesis","description":"This cluster centers on developmental processes across neural and cardiac lineages, with terms for neurogenesis, heart development, dendritic spine morphogenesis, and cell adhesion, plus transcriptional regulation and cytoskeletal signaling (Rho). The mix suggests a developmental/a morphogenesis focus connecting neural connectivity and heart formation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0035584","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0010863","count":2}]},{"hash":"577530190964965569","title":"Ubiquitin-mediated TNF/NF-\u03baB signaling","description":"Dominant terms center on ubiquitin-dependent protein degradation and autoubiquitination, including K63-linked ubiquitination, together with innate immune responses and TNF signaling leading to NF-\u03baB activation. This suggests the cluster comprises proteins regulating inflammatory signaling via ubiquitin-mediated pathways, particularly TNF and NF-\u03baB.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0051865","count":9},{"id":"GO:0030433","count":9},{"id":"GO:1903265","count":8},{"id":"GO:1903721","count":7}]},{"hash":"1407418022924680872","title":"Embryonic morphogenesis and organogenesis","description":"The terms point to embryonic development across multiple tissues: cranial skeleton and eye morphogenesis, habenula development, heart ventricular morphogenesis, and in utero development, plus transcriptional regulation during development and cellular proliferation in muscle. This suggests a coherent theme of early organ formation and tissue differentiation, not limited to a single tissue. ","confidence":"High","size":20,"edges":111,"triangles":299,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048701","count":7},{"id":"GO:0048048","count":6},{"id":"GO:0090394","count":5},{"id":"GO:0001666","count":5},{"id":"GO:0021986","count":5}]},{"hash":"504902415527400651","title":"Retina Development and Visual GPCR Signaling","description":"The top terms cluster around vision and retina biology (retina development, visual perception, visual learning) and GPCR signaling pathways (adenylate cyclase-activating adrenergic receptor signaling, adenosine receptor signaling), suggesting these proteins are tied to retinal development and visual signal transduction via GPCRs. Some general terms on transcription and proliferation appear but do not define the main theme.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0060041","count":4},{"id":"GO:0071880","count":4},{"id":"GO:0001973","count":4},{"id":"GO:0007601","count":4}]},{"hash":"731780986650536719","title":"Neural and sensory organ development","description":"The top GO terms center on brain development, inner ear development, retina development, and neural crest cell migration, which collectively point to neural and sensory tissue formation during embryogenesis. Other terms like endocrine pancreas and digestive tract morphogenesis suggest broader organogenesis, but the strongest signal is neural/sensory development. This label captures the dominant theme while acknowledging some heterogeneity in the full term set.","confidence":"Medium","size":20,"edges":6,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007626","count":12},{"id":"GO:0007420","count":12},{"id":"GO:0048839","count":12},{"id":"GO:0048557","count":10},{"id":"GO:0090190","count":10}]},{"hash":"2058947063565688291","title":"Neural development and axon guidance","description":"The GO terms center on nervous system and CNS development, neurogenesis, axonogenesis, and fasciculation of motor neuron axons, with supporting cell\u2013cell adhesion terms\u2014titting together as a neural development/axon pathfinding module. Some obsolete terms appear but do not alter the core theme. The dense network (edges/triangles) supports a cohesive functional cluster in neural development.","confidence":"High","size":20,"edges":186,"triangles":1072,"max_degree":19,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007399","count":11},{"id":"GO:0007417","count":11},{"id":"GO:0006915","count":11},{"id":"GO:0022008","count":11},{"id":"GO:1902960","count":10}]},{"hash":"2271456704004508340","title":"Unknown","description":"The terms span diverse biological processes\u2014reproduction (oocyte karyosome formation, spermatogenesis, tooth odontogenesis), immune signaling (NF-kB, T cell receptor regulation), nuclear organization (NLS-mediated import, PML body), development (optic nerve morphogenesis), and other functions (potassium transport, amyloid regulation). There is no unifying function tying these proteins together, so a cohesive label cannot be assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030717","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0042475","count":2}]},{"hash":"1581069216179009135","title":"Unknown","description":"The GO terms are highly diverse (translation, signal transduction regulation, hair/skin development, blood vessel maturation, immune differentiation, plus some obsolete or nonsensical terms), showing no coherent shared function among the 20 proteins; thus a meaningful single label cannot be confidently assigned.","confidence":"","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0009966","count":1},{"id":"GO:0043666","count":1},{"id":"GO:0043086","count":1},{"id":"GO:0005977","count":1}]},{"hash":"1640397492187619772","title":"Rho-driven morphogenesis and synapse formation","description":"The terms cluster around developmental morphogenesis across tissues (dendritic spine morphogenesis, cochlea morphogenesis, heart development) together with synaptic organization (protein localization to synapse, receptor clustering) and Rho signaling (Rho protein signal transduction and regulation). This suggests these proteins participate in shaping tissues and neural connections via Rho pathways, justifying a label focused on morphogenesis and synapse formation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0090103","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0035418","count":2}]},{"hash":"2071502453457300890","title":"Epidermal differentiation and wound-healing signaling","description":"The terms cluster around keratinocyte differentiation, wound healing, and integrin-mediated signaling, with cytoskeletal remodeling supporting these processes, pointing to epidermal remodeling and repair as the core theme. A few terms touch on broader developmental programs, but the strongest link is epidermal differentiation and wound healing.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":3},{"id":"GO:0035313","count":2},{"id":"GO:0000186","count":2},{"id":"GO:0031659","count":2},{"id":"GO:0007229","count":2}]},{"hash":"1277491586984675063","title":"Neuronal development and sensory signaling","description":"Top GO terms emphasize neural development and sensory functions: presynapse assembly, sensory neuron axon guidance, and visual perception, suggesting a focus on how neurons form and operate in sensory pathways. Additional terms related to pheromone response and hippo signaling point to development and growth coordination that can influence neural connectivity. While some terms touch on general cell division, the dominant theme is neuronal development and sensory processing. ","confidence":"High","size":20,"edges":181,"triangles":995,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":10},{"id":"GO:0019236","count":10},{"id":"GO:1905608","count":10},{"id":"GO:0007117","count":10},{"id":"GO:0050709","count":10}]},{"hash":"510069534903149774","title":"SNARE-Mediated Vesicle Trafficking","description":"The frequent GO terms point to SNARE complex assembly, Golgi retention, vacuole targeting, and exocytic membrane fusion, suggesting a cluster of proteins that drive vesicle trafficking and membrane fusion in the secretory pathway. While there are hints of other processes (cell division, apoptosis), the dominant signal is intracellular trafficking and membrane fusion.","confidence":"High","size":20,"edges":25,"triangles":3,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0042144","count":4},{"id":"GO:0045053","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0015991","count":3}]},{"hash":"1084739162378945294","title":"Transsulfuration and central carbon metabolism","description":"This cluster is enriched for hydrogen sulfide biosynthesis, transsulfuration, and cysteine biosynthesis terms, alongside oxaloacetate metabolism, the TCA cycle, and glycolysis. The combination points to proteins involved in amino acid sulfur metabolism that interfaces with core energy pathways, suggesting a cohesive role in sulfur amino acid metabolism linked to central metabolism rather than a single isolated pathway. ","confidence":"Medium","size":20,"edges":188,"triangles":1105,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006107","count":6},{"id":"GO:0006099","count":6},{"id":"GO:0070814","count":5},{"id":"GO:0019343","count":5},{"id":"GO:0019346","count":5}]},{"hash":"1440391811332311093","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms point to development and morphogenesis across multiple tissues (pituitary gland, osteoblasts/bone, palate, heart outflow tract, neural crest migration, kidney ureteric branching) along with general transcription and differentiation processes, suggesting a broad embryonic development program rather than a single tissue-specific function.","confidence":"Medium","size":20,"edges":81,"triangles":108,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0002076","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0003148","count":5},{"id":"GO:0006351","count":5}]},{"hash":"201125553977942540","title":"Embryonic vascular and neural crest development","description":"This cluster centers on embryonic morphogenesis with strong signals for vascular formation (angiogenesis, dorsal aorta development) and neural crest\u2013driven processes (neural crest cell migration, melanocyte migration, autonomic nervous system development), plus related CNS development. A few hematopoietic terms are present but overall the pattern points to coordinated vascular and neural crest development during embryogenesis.","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0098869","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0097324","count":2}]},{"hash":"64760099857818207","title":"Skin Development and Actin Cytoskeleton Remodeling","description":"Top GO terms indicate epidermal development and barrier formation (establishment of skin barrier, skin development, keratinocyte migration) together with cytoskeletal dynamics (cortical actin cytoskeleton organization, podosome assembly). This pattern supports a label focusing on keratinocyte adhesion/motility and skin barrier formation, with actin remodeling as a central mechanism. Some terms like complement activation and osteoclast differentiation are less central but may reflect shared actin-related pathways.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0061436","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0090002","count":2},{"id":"GO:0030316","count":2}]},{"hash":"132435167861810452","title":"Embryonic tissue morphogenesis and development","description":"The GO terms cluster around morphogenesis and development across diverse tissues (neuronal dendrite/spine formation, cartilage, placenta/embryo development, heart-associated EMT, endocrine/pancreatic development, left-right patterning). There isn\u2019t a single specific molecular pathway tying them all, but they share the overarching theme of developmental processes and tissue morphogenesis.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0060536","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1}]},{"hash":"794083850257291316","title":"Neurodevelopment","description":"The strongest GO signals are neural-related: brain development, forebrain development, dendrite development, and neuron apoptotic process, indicating the proteins cluster around nervous system development. Some terms (skin development, multicellular organism development, translation-related terms) are broader or less specific, but do not override the overall neural development theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0032782","count":4},{"id":"GO:0016358","count":4},{"id":"GO:0007275","count":3}]},{"hash":"1326071861624581722","title":"Vascular Development and Inflammation","description":"The top GO terms center on endothelial biology (cell surface receptor signaling, endothelial cell migration, regulation of endothelial differentiation, blood vessel development) along with somitogenesis and inflammatory response, suggesting a cluster tied to vascular development and associated inflammatory/signaling processes. DNA damage response adds a layer of stress signaling that can accompany development. Some terms about cocaine response and behavior likely reflect broader or pleiotropic annotations rather than core cluster function. Overall, the group appears to represent vascular development with inflammatory and stress-response components.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007166","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0001756","count":3},{"id":"GO:0042220","count":2},{"id":"GO:0045602","count":2}]},{"hash":"1244925592551153914","title":"Sensory modulation and drug-response signaling","description":"The top GO terms cluster around regulation of sensory perception (pain), neural gating (prepulse inhibition), and modulation of glutamatergic synaptic transmission, with added terms for responses to psychoactive drugs (amphetamine, morphine) and learning. Also present are receptor internalization and ion transport terms tied to neuronal signaling, and a developmental term for a sensory system (lateral line). Together, these suggest a cohesive theme of sensory processing and modulation of neural signaling in response to drugs.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":5},{"id":"GO:0060134","count":5},{"id":"GO:0051967","count":5},{"id":"GO:0001975","count":5},{"id":"GO:0008542","count":4}]},{"hash":"1774950998479938241","title":"Neuronal axon guidance and cell adhesion","description":"This cluster is driven by GO terms related to neuron axon guidance (serotonergic and dopaminergic), protein localization to axon subdomains (paranode/juxtaparanode), and cell adhesion (homophilic and heterophilic). Together, these point to neural development and axon pathfinding with cell adhesion and polarity cues; other terms like planarity and apical localization support broader polarity/morphogenesis themes but the strongest signal centers on neurons. ","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0071205","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0090251","count":2}]},{"hash":"1467409250327868983","title":"Actin Cytoskeleton Dynamics","description":"The top GO terms cluster around actin filament network formation and formin-nucleated actin assembly, with related notes on microtubule regulation and centrosome localization, all pointing to cytoskeletal remodeling. Some context-specific terms (synaptic depression, histamine response) reflect downstream or cell-type contexts of actin dynamics, but the dominant theme is actin cytoskeleton remodeling and its coordination with microtubules.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051639","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0070649","count":2},{"id":"GO:0007182","count":2},{"id":"GO:0007026","count":2}]},{"hash":"239702585188263629","title":"Multiorgan Developmental Signaling","description":"The top GO terms point to development across multiple organs (heart, kidney, spermatid, bone formation) and include regulators of key signaling pathways (Wnt, SMAD) and processes like asymmetric cell division. This suggests a theme of broad developmental regulation and signaling control rather than a single tissue-specific function, justifying a label that captures cross-tissue developmental signaling. The lack of interaction edges does not undermine the thematic connection to developmental processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0007286","count":2},{"id":"GO:0035414","count":2},{"id":"GO:0060394","count":2}]},{"hash":"2042081491125847348","title":"UV-Response DNA Repair and Translesion Synthesis","description":"The top GO terms point to DNA damage response and repair pathways activated by UV damage, including nucleotide-excision repair, DNA gap filling, and both error-prone and error-free translesion synthesis, along with DNA replication. A few transcription-related terms are present, but the strongest signal is UV-induced DNA repair and lesion bypass, suggesting the cluster centers on DNA damage response and translesion synthesis mechanisms.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":1},{"id":"GO:0042795","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0042276","count":1},{"id":"GO:0071494","count":1}]},{"hash":"1947261067506057165","title":"Ectodermal organ development","description":"The top GO terms are dominated by development of ectoderm-derived structures: inner ear (labyrinthine layer development, inner ear development), hair follicle morphogenesis and body hair planar orientation, and craniofacial development (roof of mouth development). A few terms like translation and B cell differentiation appear as minor noise, but the overall signal points to ectodermal organ formation, especially hair and ear. Confidence in this label is Medium.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060711","count":2},{"id":"GO:0048839","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0006412","count":1}]},{"hash":"1869992089283385124","title":"Neural development and cell-cycle regulation","description":"The cluster shows strong signals for cell-cycle\u2013related processes (cell division, APC-dependent catabolic process, K11-linked ubiquitination) alongside neural development terms (axonogenesis, neuron migration, axon guidance), suggesting proteins that may coordinate cell-cycle control with neural differentiation and axon guidance during development, with adhesion and organ identity terms providing context for tissue remodeling. ","confidence":"Medium","size":20,"edges":46,"triangles":64,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:2000324","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0070979","count":4},{"id":"GO:0048496","count":3}]},{"hash":"1988043653739571217","title":"Sensory Neuron Development","description":"The top GO terms indicate neural and sensory development: auditory receptor development, detection of mechanical stimulus in sound, semaphorin-plexin axon guidance, dendrite self-avoidance, and trigeminal nerve organization. Some terms refer to other lineages (megakaryocyte development, lymphoid differentiation, ossification), which may reflect annotation noise; overall the cluster\u2019s common theme is sensory neuron development.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060117","count":2},{"id":"GO:0050910","count":2},{"id":"GO:0070593","count":2},{"id":"GO:0002320","count":2},{"id":"GO:0010693","count":2}]},{"hash":"831225747638683115","title":"Genome maintenance and RNA regulation","description":"Explanation: The dominant GO terms are DNA recombination and base-excision repair, pointing to genome maintenance, along with regulation of mRNA stability, indicating RNA-level control. Some terms (redox homeostasis, phosphatidylinositol dephosphorylation, corneocyte development) appear peripheral or noisy, but the core signal centers on nucleic acid maintenance and RNA regulation, justifying the label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":9},{"id":"GO:0090502","count":9},{"id":"GO:0045454","count":8},{"id":"GO:0014912","count":8},{"id":"GO:0003335","count":8}]},{"hash":"1769073445820284513","title":"Ubiquitin-Dependent Regulation of Signaling and Cell Cycle","description":"The top GO terms emphasize ubiquitination and ubiquitin-dependent protein catabolic processes, alongside regulatory roles in signaling pathways (NF-kappaB, TLR), transcription, necroptosis and apoptosis, and cell cycle control. This suggests a cohesive function in ubiquitin-mediated control of signaling and cell cycle processes, rather than disparate roles. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0060544","count":3}]},{"hash":"1500534883806488119","title":"Angiogenesis and immune signaling","description":"The cluster shows enrichment for angiogenesis (GO:0001525) and a range of immune-related processes, including antigen processing/presentation via MHC I, dendritic cell cytokine production, and regulation of NK/T cell activity, plus VEGF\u2011associated signaling. While a few neural or stress-granule terms appear, the dominant pattern points to coordinated vascular and immune signaling. Confidence: Medium.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0035234","count":3},{"id":"GO:0034063","count":2},{"id":"GO:0071205","count":2},{"id":"GO:0060117","count":2}]},{"hash":"1455070408373200129","title":"Mitotic Spindle Assembly Checkpoint and Chromosome Segregation","description":"This cluster is dominated by GO terms related to the mitotic spindle assembly checkpoint, spindle-kinetochore attachments, and chromosome movement, with ubiquitin-dependent protein catabolic processes suggesting regulation of mitotic progression. While a couple terms (thymus development, T cell proliferation) are unrelated to mitosis, the core signal points to mitotic control and chromosome segregation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0090235","count":1},{"id":"GO:0007094","count":1},{"id":"GO:0044774","count":1},{"id":"GO:1901925","count":1}]},{"hash":"755270195184043948","title":"Vesicle Trafficking and Protein Sorting","description":"The top GO terms show a clear pattern of intracellular vesicle transport and cargo sorting, including Golgi-ER transport in both directions, Golgi to vacuole transport, endocytosis, endosome-to-Golgi retrograde transport, and synaptic vesicle transport. This points to a cohesive role in vesicle trafficking pathways and protein targeting within the cell, with a few peripheral terms (e.g., Purkinje cell maturation, response to virus) likely secondary associations. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901998","count":1},{"id":"GO:0006890","count":1},{"id":"GO:0006897","count":1},{"id":"GO:0006896","count":1},{"id":"GO:0006888","count":1}]},{"hash":"894128294295626979","title":"Vascular development and GTPase signaling cluster","description":"This group shows a clear emphasis on endothelial biology and angiogenesis-related processes (endothelial tube lumen extension, negative regulation of blood vessel remodeling, sprouting angiogenesis) and on small GTPase\u2013mediated signaling, suggesting a vascular development/signaling theme. The presence of other terms (ER unfolded protein response, extrinsic apoptotic signaling, TNF production, osteoclast differentiation) indicates broader, less specific roles, making the overall connection somewhat heterogeneous. With no observed edges linking proteins, the label reflects a dominant vascular signaling axis rather than a tightly cohesive function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900103","count":1},{"id":"GO:0008625","count":1},{"id":"GO:0021816","count":1},{"id":"GO:0060313","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1875614601769780413","title":"Chromatin regulation and cell cycle control","description":"The GO terms point to nuclear processes: transcription, chromatin modification (histone H3 methylation and acetylation), and ubiquitination, plus cell-cycle related activities (G0 to G1 transition, mitotic spindle assembly, nuclear pore localization). This suggests a cohesive theme of chromatin regulation linked to cell-cycle progression rather than a single enzymatic function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051567","count":2},{"id":"GO:0070262","count":1}]},{"hash":"1626081573957772706","title":"Vertebrate Embryonic Organogenesis","description":"This cluster is enriched for diverse vertebrate developmental processes (heart, eye, palate, forebrain, skeletal muscle, cartilage differentiation, somitogenesis) and angiogenesis, suggesting a common theme of embryonic organogenesis and morphogenesis rather than a single tissue function.","confidence":"High","size":19,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0032332","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0043010","count":4}]},{"hash":"2282979227308624404","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around developmental and morphogenetic processes across multiple tissues and lineages (cartilage morphogenesis, trophoblast giant cell differentiation, endocrine system development, endocardial cushion formation, pancreatic cell development, placenta-related differentiation, and left-right pattern formation). A few terms relate to RNA processing and transcription regulation, but the dominant theme is embryonic development and organ/tissue morphogenesis, justifying a label that emphasizes developmental processes. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0003323","count":6}]},{"hash":"746405328879920622","title":"DNA Replication and Transcription Proteins","description":"This cluster is mainly characterized by GO terms tied to DNA replication and transcription, including DNA replication (GO:0006260), DNA-templated transcription (GO:0006351), and DNA strand elongation in replication (GO:0006271). While a few other terms (some obsolete or related to protein modification) appear, the strongest and most frequent annotations point to nucleic acid\u2013metabolic functions, suggesting the proteins are involved in replication and transcription processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006465","count":2}]},{"hash":"2101856989837135856","title":"Cerebellar development and neural signaling","description":"The top GO terms point to cerebellar biology, with cerebellar cortex formation and Bergmann glial differentiation, plus regulation of axon regeneration, suggesting neural development in the cerebellum. The presence of DNA replication and centrosome cycle terms alongside proliferation regulation indicates concurrent cell-cycle control during development. While insulin and T cell receptor signaling appear, the cerebellar development aspects provide the strongest cohesive theme for this cluster.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0007098","count":3},{"id":"GO:0010571","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0008286","count":3}]},{"hash":"1668417197594947053","title":"RNA processing and translation regulation","description":"This cluster centers on RNA lifecycle and control of protein synthesis, as shown by terms like nonsense-mediated decay, regulation of translational initiation, miRNA-mediated silencing by inhibition of translation, mRNA splicing site recognition, and IRES-dependent viral translation. The mix of mRNA processing, stability, and translation initiation/termination suggests a cohesive theme around RNA metabolism and regulation of translation rather than a single pathway.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":2},{"id":"GO:0097010","count":1},{"id":"GO:1902625","count":1},{"id":"GO:0075522","count":1},{"id":"GO:1903586","count":1}]},{"hash":"691748099113464710","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":2},{"id":"GO:2000637","count":2},{"id":"GO:0010586","count":2},{"id":"GO:1903265","count":2},{"id":"GO:1903883","count":2}]},{"hash":"468221395881414587","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0006888","count":3}]},{"hash":"171522280232265296","title":"Organogenesis and Tissue Differentiation","description":"The cluster's top GO terms point to developmental and differentiation processes across diverse tissues: heart development, fat cell differentiation, chondrocyte differentiation, glomerular basement membrane development, semicircular canal morphogenesis, and positive regulation of synapse assembly. There's also a cellular response to mechanical stimulus, consistent with morphogenesis and tissue remodeling; while a few terms touch immune or receptor binding, the dominant signal is organogenesis and tissue differentiation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010745","count":5},{"id":"GO:0045444","count":5},{"id":"GO:0071260","count":4},{"id":"GO:0048752","count":4},{"id":"GO:0007507","count":4}]},{"hash":"1102925528164113297","title":"Neural development and synaptic plasticity","description":"This cluster is dominated by terms tied to neural function: excitatory postsynaptic potential, long-term potentiation, axonogenesis, visual perception, and Schwann cell development, indicating roles in neural development, synaptic maturation, and plasticity. Non-neural terms present (mitotic cell cycle, G2/M, myoblast fusion, abscisic acid signaling) may reflect broader developmental processes or annotation artifacts, but do not override the central neural theme.","confidence":"High","size":19,"edges":119,"triangles":461,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":15},{"id":"GO:0010800","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0009738","count":15},{"id":"GO:0000278","count":15}]},{"hash":"630054757139906678","title":"Tissue morphogenesis and development","description":"The top GO terms cluster around cell adhesion, skin development, ossification, mammary duct growth, myoblast proliferation, apical constriction, and plasminogen activation, all of which point to tissue formation, remodeling, and development across epithelia, bone, muscle, and glands. Calcium transport and synapse assembly terms support signaling and structural changes typical of morphogenesis. Although an immune term appears, the dominant pattern is developmental tissue morphogenesis.","confidence":"High","size":19,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0070588","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0051965","count":2}]},{"hash":"2131522416618972449","title":"Unknown","description":"Top terms are diverse and sparse (each with count 1), spanning ion transmembrane transport, proton motive force-driven ATP synthesis, defense response to virus, eye development, protein targeting to membranes, multicellular development, dsRNA response, mitochondrial fission, and T cell chemotaxis. With no strong shared function or pathways, and no edges among the proteins, there is no coherent theme to label. Therefore, Unknown with confidence None.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0099132","count":1},{"id":"GO:0042777","count":1},{"id":"GO:0002230","count":1},{"id":"GO:0043010","count":1},{"id":"GO:0090314","count":1}]},{"hash":"1874701344105082552","title":"Spermatogenesis and germ cell development","description":"The top terms are dominated by spermatogenesis and spermatid development, with multicellular growth supportive of developmental processes, suggesting the cluster centers on male germ cell formation and maturation. Other terms like ribosomal export and mRNA splicing reflect general cellular machinery but do not override the germ-cell development signal.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0032298","count":1},{"id":"GO:0000398","count":1}]},{"hash":"1989684439820663348","title":"RNA Processing and Translation Regulation","description":"This cluster is characterized by enrichment in GO terms involving regulation of mRNA splicing, polyadenylation, stability, and translation initiation, including IRES-dependent initiation, indicating a theme of RNA maturation and translational control.","confidence":"High","size":19,"edges":88,"triangles":268,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":12},{"id":"GO:0048026","count":12},{"id":"GO:1901407","count":11},{"id":"GO:0006378","count":11},{"id":"GO:0010610","count":11}]},{"hash":"1281694830774766215","title":"Ubiquitination and NF-kappaB signaling regulation","description":"Top terms strongly point to ubiquitin-related protein turnover (autoubiquitination, proteolysis, various polyubiquitin linkages) and regulation of inflammatory signaling (TNF, NF-kappaB), including necroptosis control.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":9},{"id":"GO:0042787","count":9},{"id":"GO:0036205","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0085020","count":8}]},{"hash":"1401085976240291508","title":"Glutamatergic synaptic transmission and plasticity","description":"The proteins in this cluster are enriched for neural signaling terms, including glutamatergic synaptic transmission, neurotransmitter secretion, and long-term potentiation, pointing to a core function in glutamatergic synapses and synaptic plasticity. Some outlier terms (abscisic acid signaling, myoblast fusion, sphingolipid biosynthesis) are present but do not outweigh the central theme of neuronal communication and membrane signaling at synapses.","confidence":"High","size":19,"edges":112,"triangles":304,"max_degree":17,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0034351","count":4},{"id":"GO:0009738","count":4},{"id":"GO:0060963","count":4},{"id":"GO:0035249","count":4},{"id":"GO:0007269","count":4}]},{"hash":"25239821331156124","title":"Embryonic organogenesis","description":"The top GO terms center on development and morphogenesis across multiple organs (midbrain and forebrain patterning, neural crest migration, pituitary development, pancreatic/endocrine development, digestive tract morphogenesis, and ureteric bud branching). A general theme is embryonic tissue differentiation and organ formation, with transcriptional regulation noted as part of developmental control, suggesting this cluster represents embryonic organogenesis rather than a single organ-specific process.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":10},{"id":"GO:0090190","count":7},{"id":"GO:0031018","count":7},{"id":"GO:0048557","count":6}]},{"hash":"1347791846616253784","title":"mRNA processing and translation regulation","description":"This cluster is enriched for mRNA lifecycle terms, including spliceosome-driven splicing, polyadenylation and tail-length regulation, mRNA stability under stress, and translation initiation pathways (eIF4F assembly and IRES-mediated initiation), indicating a cohesive RNA metabolism and translation control module.","confidence":"High","size":19,"edges":153,"triangles":773,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":15},{"id":"GO:0006378","count":14},{"id":"GO:0031047","count":14},{"id":"GO:0048026","count":14},{"id":"GO:0045292","count":14}]},{"hash":"1047117265928471368","title":"Transcriptional Regulation and Epigenetic Control","description":"The top GO terms cluster around negative regulation of transcription by RNA polymerase II, SCF-dependent ubiquitin-proteasome\u2013mediated protein degradation, and regulation of histone methylation, pointing to a theme of gene expression control at transcriptional and epigenetic levels. Developmental and biosynthetic terms are present but appear secondary to the core regulation signal. Overall, the cluster seems best characterized by processes that modulate gene expression rather than a single specific pathway. ","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0031146","count":4},{"id":"GO:0051569","count":4},{"id":"GO:0061087","count":4},{"id":"GO:0061298","count":3}]},{"hash":"1293098097523383558","title":"GTPase-regulated signaling and adhesion","description":"The cluster centers on regulation of GTPase activity (Ras, Rho, GTPase) with accompanying processes like cell-substrate adhesion, angiogenesis, and development, suggesting proteins that modulate signaling pathways controlling cell behavior during development and tissue remodeling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007026","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0010811","count":2},{"id":"GO:0016525","count":2}]},{"hash":"234504249340657989","title":"Plant Meristem and Cell Wall Regulation","description":"The GO terms are dominated by plant-specific processes: meristem maintenance, plasmodesma organization, and plant-type cell wall cellulose biosynthesis/modification, along with transcriptional regulation that fits plant gene expression. These collectively suggest a module governing plant development and intercellular transport, despite a couple of non-plant terms appearing sparsely. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060907","count":2},{"id":"GO:0048843","count":2},{"id":"GO:2001009","count":1},{"id":"GO:0009831","count":1},{"id":"GO:0009663","count":1}]},{"hash":"1344615455128611712","title":"Detoxification and xenobiotic metabolism","description":"The top GO terms emphasize detoxification and responses to toxic substances (cellular oxidant detoxification, response to toxic substance) alongside various catabolic processes (lipid- and glycoside-related) and some biosynthetic activities. This pattern suggests proteins involved in breaking down and neutralizing toxic compounds and processing diverse metabolites, rather than a single specific pathway. Therefore, a concise label focusing on detoxification and general metabolism is appropriate.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0009102","count":4},{"id":"GO:0019433","count":4},{"id":"GO:0046839","count":3},{"id":"GO:0046272","count":3}]},{"hash":"764847340918765109","title":"Embryonic Organ Development","description":"GO terms point to development and morphogenesis across multiple organs: bone ossification, spinal cord and kidney development, heart tissue growth, palatal shelf morphogenesis, and neuronal stem cell maintenance. The consistent theme is embryonic organogenesis and tissue formation, with associated cell-cell adhesion suggesting coordinated tissue structuring.","confidence":"High","size":19,"edges":59,"triangles":117,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0061419","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0021510","count":3}]},{"hash":"2202239411744461238","title":"Ubiquitin-Mediated Protein Regulation","description":"The dominant GO terms center on ubiquitination\u2014polyubiquitination and ubiquitin-dependent protein catabolic processes\u2014suggesting a shared role in tagging proteins for degradation or regulation. Related terms such as circadian rhythm regulation and Golgi vesicle coating may reflect broader cellular regulation, but ubiquitin-mediated control of protein turnover is the core theme.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042752","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0071226","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0048205","count":2}]},{"hash":"1110668561203191401","title":"Angiogenesis and vascular maturation","description":"This cluster is dominated by GO terms related to vascular development and endothelial interactions, including blood vessel maturation and cadherin-mediated cell-cell adhesion, with supporting signals from fibroblast proliferation regulation and development processes. The combination points to a theme of vascular formation and maturation rather than general transcriptional control, making \"Angiogenesis and vascular maturation\" an appropriate, specific label.","confidence":"High","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0048147","count":2},{"id":"GO:0055096","count":2},{"id":"GO:0001955","count":2},{"id":"GO:0044331","count":2}]},{"hash":"1043970809033054182","title":"Proteostasis and Redox Metabolism","description":"The terms point to cellular maintenance of protein folding (ER) and redox balance, plus related metabolic pathways (respiration, insulin signaling, amyloid-beta turnover). While broad terms like viral process and transcription are present, the dominant theme appears to be proteostasis linked to metabolism.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0034975","count":2}]},{"hash":"678440101488954118","title":"Neurodevelopment and eye morphogenesis","description":"This cluster is dominated by vertebrate embryonic development terms centered on neural and eye formation\u2014motor neuron and retinal axon guidance, forebrain and eye morphogenesis\u2014along with broader somite and heart patterning terms that reflect overall organogenesis.","confidence":"High","size":19,"edges":13,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0021759","count":6},{"id":"GO:0008045","count":6},{"id":"GO:0030900","count":6},{"id":"GO:0060971","count":6}]},{"hash":"1336850813248837638","title":"Synaptic vesicle trafficking in neurons","description":"The top GO terms are dominated by synaptic vesicle exocytosis and endocytosis regulation, plus neuron-related development terms (substantia nigra development, dendrite morphogenesis). There are also trafficking-related terms (Golgi to plasma membrane transport, protein transport) that fit with neuronal vesicle cycling. While some terms touch on other processes (angiogenesis, chromatin), the clearest signal is neuronal vesicle trafficking, justifying this label with moderate confidence.","confidence":"Medium","size":19,"edges":19,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006893","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0007205","count":2},{"id":"GO:2000300","count":2}]},{"hash":"267267132663815181","title":"Immune activation and tissue remodeling","description":"This cluster is dominated by GO terms for adaptive and innate immune responses, complement activation, proteolysis, and angiogenesis, pointing to an immune-activated state with extracellular matrix remodeling. Additional terms indicate signaling via the ERK cascade and collagen fibril organization, supporting inflammation-driven tissue remodeling. The neuronal-related terms (glutamatergic synaptic transmission) and host\u2013symbiont entry hints are less central but may reflect immune\u2013neural crosstalk and pathogen interactions. Overall, the common theme is immune activation intertwined with tissue remodeling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":4},{"id":"GO:0006508","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051968","count":3},{"id":"GO:0001525","count":3}]},{"hash":"2217485487471467819","title":"Transmembrane Ion and Metabolite Transporters","description":"The cluster is dominated by GO terms for transmembrane transport, covering ions (sodium, potassium, arsenite, monoatomic anion) and small metabolites (malate, citrate, succinate), plus the general transmembrane transport term. This pattern suggests a cohesive group of membrane transporter proteins rather than a single metabolic enzyme, hence the name. A peptidoglycan catabolic term appears but is less representative of the overall function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009253","count":2},{"id":"GO:0015743","count":1},{"id":"GO:0015746","count":1},{"id":"GO:0006814","count":1},{"id":"GO:0055085","count":1}]},{"hash":"359317855742945659","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0000447","count":1}]},{"hash":"456693826203519976","title":"GPCR-driven cAMP/cGMP Signaling","description":"The cluster is dominated by GPCR-related signaling terms (adenosine receptor signaling, adrenergic receptor signaling) and second messenger production (cAMP and cGMP), plus intracellular signal transduction, pointing to a cohesive set of proteins functioning in GPCR-mediated cyclic nucleotide signaling. The presence of related cues such as blue light signaling and hypoxia detection suggests a broader signaling module rather than a single, narrow pathway. Confidence: High","confidence":"","size":19,"edges":27,"triangles":12,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0009785","count":17},{"id":"GO:0001973","count":17},{"id":"GO:0006171","count":17},{"id":"GO:0071880","count":17},{"id":"GO:0035556","count":17}]},{"hash":"480271434003732707","title":"Organ and tissue development","description":"The top GO terms point to development and growth of multiple organs and tissues (retina vasculature, digestive tract, tongue muscle differentiation, uterus, female genitalia, prostate), suggesting a general organogenesis theme rather than a single pathway.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":19},{"id":"GO:0048565","count":19},{"id":"GO:2001037","count":19},{"id":"GO:0060065","count":19},{"id":"GO:0001516","count":19}]},{"hash":"2285192422536088943","title":"Synaptic and ECM Regulation","description":"The top GO terms point to synapse assembly and maintenance (positive regulation of synapse assembly, maintenance of synapse structure) together with collagen fibril organization, implying a theme where neural connectivity is modulated in concert with extracellular matrix remodeling. Additional terms for BMP response and motor learning support neural development and plasticity, while other terms reflect broader ECM/immune processes, suggesting a central theme with some peripheral signals. Overall, the label captures the core connection between synaptic organization and extracellular matrix dynamics.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0061743","count":1},{"id":"GO:0071773","count":1}]},{"hash":"1034115409359967238","title":"Developmental Morphogenesis and Signaling","description":"This cluster shows proteins associated with multiple developmental and morphogenetic processes, including heart development, cerebellum morphogenesis, blood vessel maturation, and synapse assembly, as well as insulin receptor signaling and DNA-templated transcription. The mix of morphogenesis, neural development, and signaling GO terms suggests a broad developmental/morphogenic program rather than a single, cohesive pathway, with some chromatin-related terms possibly reflecting chromatin remodeling during development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":2},{"id":"GO:0021587","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0030702","count":2},{"id":"GO:0006348","count":2}]},{"hash":"133468663648941415","title":"Epithelial Junctions and Polarity Signaling","description":"This cluster is driven by GO terms that center on cell\u2013cell adhesion and epithelial polarity (protein localization to adherens junction; maintenance of apical/basal polarity) and cytoskeletal regulation (Rho signaling), with supporting notes on broader signaling pathways. The combination strongly points to proteins coordinating junction formation/maintenance and cell polarity in epithelial contexts, rather than a single specific pathway.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0050808","count":2},{"id":"GO:0070433","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0045075","count":1}]},{"hash":"875050290854123581","title":"Synaptic receptor trafficking and spine remodeling","description":"This cluster prominently features GO terms tied to endocytosis and transport of neurotransmitter receptors to the postsynaptic membrane, along with regulation of GTPases (Rho/Rac) that drive cytoskeletal remodeling and dendritic spine modification. The combination points to coordinated receptor trafficking at the synapse and spine plasticity. Additional terms related to BMP signaling, ER stress, and ESCRT-mediated processes may reflect broader neuronal signaling and trafficking contexts, but the core theme centers on synaptic receptor movement and spine structural changes.","confidence":"Medium","size":19,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:1900144","count":2},{"id":"GO:0035024","count":2},{"id":"GO:0098886","count":2},{"id":"GO:0098887","count":2}]},{"hash":"1996486557584025565","title":"Arginine Transport and Macrophage NO Production","description":"Top GO terms indicate import of L-arginine (and related amino acids) across the plasma membrane and nitric oxide biosynthesis within inflammatory macrophage responses, plus regulation of macrophage activation. This points to a theme where amino acid transport feeds macrophage NO signaling during inflammation. Despite no reported edges, the shared annotations suggest a cohesive immune-metabolic function centered on arginine utilization for NO production.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097638","count":1},{"id":"GO:0042116","count":1},{"id":"GO:0006809","count":1},{"id":"GO:0002537","count":1},{"id":"GO:0097640","count":1}]},{"hash":"1670339258346460088","title":"Unknown","description":"The GO terms are highly diverse (behavior, receptor clustering, ubiquitination, mitochondrial import, iron starvation response, snoRNP assembly, chromatin remodeling, and developmental processes), with no clear shared function tying the proteins together, suggesting there is no coherent single module represented.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035640","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0016567","count":1},{"id":"GO:0045041","count":1},{"id":"GO:0010106","count":1}]},{"hash":"1814118691390190806","title":"Rho-GTPase-Mediated Actin Remodeling","description":"This cluster is dominated by GO terms for Rho protein signal transduction and its regulation, plus actin cytoskeleton organization and microvillus assembly, pointing to Rho-driven remodeling of the actin cytoskeleton across cell types. Connections to epithelial barrier formation, sensory hair cell structures, and brain development further support a unifying theme of actin dynamics governed by Rho signaling. A few terms (e.g., dendritic cell apoptotic regulation) are less directly tied but don\u2019t override the central theme. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:2000670","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0019933","count":3},{"id":"GO:0090557","count":3}]},{"hash":"2226493261108650397","title":"Unknown","description":"The GO terms span diverse processes (apoptosis, DNA repair, redox homeostasis, mRNA stability, development) with no clear shared function, and the cluster has few connections, making it hard to assign a coherent, representative label.","confidence":"","size":19,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0043488","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0014912","count":3},{"id":"GO:0003335","count":3}]},{"hash":"320338738202690023","title":"Embryogenesis and Pregnancy-Related Development","description":"The GO terms dominated by embryo implantation, endodermal differentiation, and maternal pregnancy processes indicate a focus on embryonic development and maternal-fetal interactions. Additional terms referencing vascular maturation and ossification fit into broader developmental contexts. While a few terms are more general (protein localization to plasma membrane, hydrogen peroxide metabolism), the core signal centers on developmental events around pregnancy and embryogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":2},{"id":"GO:0072659","count":2},{"id":"GO:0042518","count":2},{"id":"GO:0001955","count":1},{"id":"GO:0007566","count":1}]},{"hash":"839331176581355536","title":"Chromatin remodeling and transcriptional regulation","description":"Based on the top GO terms, this cluster centers on chromatin dynamics (histone exchange, nucleosome mobilization, histone acetylation), transcription initiation at RNA polymerase II promoters, and heterochromatin formation, indicating a role in epigenetic regulation of gene expression. A few terms touch development (segment specification, Wnt/PCP signaling) but the dominant signal is chromatin remodeling and transcription control, consistent with a cohesive functional theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0048510","count":1},{"id":"GO:0042766","count":1},{"id":"GO:0006348","count":1}]},{"hash":"478007525564514346","title":"Unknown","description":"The GO terms span redox homeostasis, RNA stability regulation, DNA repair, lipid signaling, development of corneocytes, aging, and glycogen regulation, with no single dominant process; the list is too heterogeneous to support a coherent, specific function label. Therefore the cluster is best described as Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0014912","count":3},{"id":"GO:0003335","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0043488","count":3}]},{"hash":"785033252034316198","title":"Unknown","description":"The top terms cover very different processes (Wnt signaling, pinocytosis, muscle stretch response, brown fat differentiation, cytokine production, pain detection, calcium release, and SA node electrical activity) with no clear shared function or pathway tying the proteins together. The lack of edges also suggests a heterogeneous set rather than a cohesive cluster, so a single, representative label cannot be confidently assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0035994","count":2},{"id":"GO:1903444","count":2},{"id":"GO:0071642","count":2}]},{"hash":"2031647163351052692","title":"Unknown","description":"The top GO terms are highly diverse and sparse, spanning lipid dephosphorylation, carbohydrate metabolism, redox homeostasis, cell migration, skin development, aging, RNA stability, DNA repair, and recombination. There isn\u2019t a single coherent biological theme tying these functions together, so a unified, intuitive label isn\u2019t justified.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046856","count":3},{"id":"GO:0006044","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2}]},{"hash":"1615849282950796440","title":"Vesicle trafficking and migration signals","description":"The GO terms are dominated by intracellular transport processes (late endosome to Golgi, intra-Golgi vesicle transport, astral microtubule organization) with additional annotations for cell migration and morphogenesis, suggesting a cluster centered on vesicle trafficking pathways that influence movement and development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030953","count":2},{"id":"GO:0034499","count":2},{"id":"GO:0006891","count":1},{"id":"GO:0006931","count":1},{"id":"GO:0002315","count":1}]},{"hash":"739759980749259886","title":"Unknown","description":"The terms span immune activation, ion channel clustering, cell adhesion, multiple developmental processes (olfactory bulb development, chondrocyte ossification, endoderm differentiation), and metabolic/membrane processes, with no clear single function tying the proteins together. Because there is no cohesive theme, this cluster is best labeled Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":2},{"id":"GO:0045162","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0021772","count":2},{"id":"GO:0034381","count":1}]},{"hash":"772864296847389423","title":"CNS Neuronal Migration and Synaptic Localization","description":"The GO terms cluster tightly around neuronal development and placement in the CNS, including ventral spinal cord development, lateral motor column neuron migration, cortical layer formation and tangential migration, and the reelin signaling pathway. They also emphasize synaptic localization and modulation of AMPA receptor activity, indicating a combined theme of neuronal positioning and synaptic establishment/function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":1},{"id":"GO:0021517","count":1},{"id":"GO:0097120","count":1},{"id":"GO:2000969","count":1},{"id":"GO:0097477","count":1}]},{"hash":"2229740754774827918","title":"Leukocyte adhesion and migration signaling","description":"The top GO terms cluster around immune cell adhesion and movement\u2014T cell activation via TCR-MHC, integrin signaling, heterotypic cell adhesion, substrate\u2011dependent migration, and cellular extravasation\u2014pointing to a cohesive role in leukocyte adhesion to endothelium and transmigration. Some other terms (calcium transport, memory) may reflect shared signaling pathways but are less central.","confidence":"Medium","size":18,"edges":48,"triangles":14,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0002291","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0034113","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0006929","count":3}]},{"hash":"2077009644751420467","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0046677","count":4},{"id":"GO:0006364","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0032790","count":3}]},{"hash":"1447357993170835622","title":"Phosphorylation-driven signaling and actin dynamics","description":"Top GO terms indicate coordinated regulation of GTPase activity, serine/threonine and tyrosine kinase activities, autophosphorylation, mitosis, mRNA transport, actin nucleation via Arp2/3, and hypoxia response. This points to a module of phosphorylation-dependent signaling that governs cell cycle progression and cytoskeletal remodeling. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0000278","count":6},{"id":"GO:0051028","count":6},{"id":"GO:0071456","count":6},{"id":"GO:0031954","count":6}]},{"hash":"772892292351691745","title":"Ribosome biogenesis and translation initiation","description":"The cluster\u2019s top GO terms are dominated by ribosome biogenesis, formation of the translation preinitiation complex, and translation reinitiation, all pointing to components and regulation of protein synthesis. While there are additional terms (e.g., hypoxia response, chromatin modification, ciliogenesis, spindle assembly, ubiquitination), they appear less central to the core theme, suggesting the cluster mainly reflects translation machinery and ribosome assembly activities.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0070262","count":2}]},{"hash":"1068284581672980170","title":"Mitochondrial ribosome biogenesis and translation","description":"The top GO terms cluster around translation and ribosome biogenesis (translation, ribosomal large subunit assembly, rRNA maturation, translational termination) with additional hints of a mitochondrial context (protein import into mitochondrial matrix, regulation of mitochondrial autophagy). This suggests the proteins function together in mitochondrial ribosome assembly and protein synthesis.","confidence":"High","size":18,"edges":150,"triangles":771,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0046677","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0006415","count":2},{"id":"GO:0051572","count":2}]},{"hash":"892018168265195176","title":"Neural Development and Signaling","description":"The cluster is enriched for neural-related processes, including axonogenesis, visual perception, and excitatory postsynaptic potential, along with broader multicellular development and signaling terms (adenylate cyclase activation and phosphorylation). This suggests a cohesive theme around neural development and associated signaling pathways.","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0007601","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0008360","count":5}]},{"hash":"2070682399722128344","title":"Unknown","description":"The top GO terms cover development, transcription, stress responses, immune defense, and metal ion response with no single cohesive function linking the proteins; plus there are no edges or clusters of interactions, suggesting a heterogeneous set rather than a single biological module. Confidence: None.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0070059","count":6},{"id":"GO:0030900","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0071276","count":6}]},{"hash":"1035405761082606670","title":"Neuronal development and synaptic signaling","description":"Top GO terms indicate neuron development, axonogenesis, excitatory postsynaptic potentials, and long-term synaptic potentiation, along with DNA-templated transcription and phosphorylation regulation, consistent with proteins involved in neural development and synaptic function/plasticity. Some terms (e.g., visual perception, plant hormone signaling) appear as ancillary signals but do not override the neural signature. ","confidence":"High","size":18,"edges":113,"triangles":434,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0048666","count":9},{"id":"GO:0032435","count":9},{"id":"GO:0060079","count":8},{"id":"GO:0010800","count":8}]},{"hash":"123051400107545944","title":"Diverse biosynthesis pathways","description":"The terms cluster around production of various biomolecules\u2014lipids (fatty acid elongation), hormones (estrogen, androgen), vitamins (phylloquinone, retinoic acid), and pigment synthesis (melanin)\u2014plus other biosynthetic processes like antibiotic biosynthesis. This breadth suggests a general emphasis on biosynthetic/metabolic roles rather than a single tightly defined pathway, hence the broad label.","confidence":"Medium","size":18,"edges":94,"triangles":227,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0017000","count":10},{"id":"GO:0042619","count":10},{"id":"GO:0030324","count":10},{"id":"GO:0042438","count":9}]},{"hash":"678618012050089429","title":"Vertebrate Bone, Brain, and Vascular Development","description":"This cluster\u2019s top GO terms span multiple developmental processes across tissues: bone ossification and growth plate cartilage development, blood vessel maturation, and brain development with sensory perception (sound) and synapse assembly. Cadherin-mediated cell\u2013cell adhesion ties into tissue morphogenesis, supporting a unifying theme of vertebrate organogenesis and tissue formation across skeletal, neural, and vascular systems. Confidence: High","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0001955","count":5},{"id":"GO:0044331","count":5},{"id":"GO:0007566","count":4},{"id":"GO:0003417","count":4}]},{"hash":"1346921292659775354","title":"Embryonic organogenesis and neural development","description":"This cluster's top GO terms span development and differentiation across multiple organs, especially neural and sensory tissues (midbrain-hindbrain boundary morphogenesis, neural retina development, cerebral cortex GABAergic interneuron differentiation, auditory receptor cell fate specification), with additional terms for heart, bronchiole, and neuroendocrine differentiation, indicating a broad embryonic organogenesis theme rather than a single pathway. ","confidence":"Medium","size":18,"edges":138,"triangles":617,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0021555","count":17},{"id":"GO:0003407","count":17},{"id":"GO:0021892","count":17},{"id":"GO:0003144","count":17},{"id":"GO:0071392","count":17}]},{"hash":"5017810274337694","title":"Multicellular Development and Morphogenesis","description":"These proteins cluster around developmental and morphogenetic processes, with GO terms for multicellular organism development, face morphogenesis, endodermal and mesodermal differentiation, imaginal disc eversion, ossification, and embryo implantation, suggesting a broad role in tissue formation and organization.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0060325","count":2},{"id":"GO:0042662","count":2},{"id":"GO:0007561","count":1},{"id":"GO:0001955","count":1}]},{"hash":"292322859546089281","title":"TLR4-NF-\u03baB Innate Immune Signaling","description":"This cluster is dominated by innate immune and NF-\u03baB\u2013related terms, including positive regulation of TLR4 signaling, canonical NF-\u03baB activation, innate immune response, and defense against virus. It also shows negative regulation of JAK-STAT and cytokine production, suggesting a regulatory immune-signaling module; the axon guidance term is a less central, potentially incidental signal.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":4},{"id":"GO:0034145","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0048846","count":3}]},{"hash":"484950782720909471","title":"DNA replication and repair proteins","description":"The top GO terms show DNA replication initiation and elongation, various DNA repair processes including UV-damage excision, telomere maintenance, RNA-templated DNA synthesis, and premeiotic DNA replication, suggesting a cohesive set of proteins focused on genome duplication and maintenance rather than unrelated functions.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042276","count":1},{"id":"GO:0006271","count":1},{"id":"GO:0006270","count":1},{"id":"GO:1904161","count":1},{"id":"GO:0000738","count":1}]},{"hash":"1462807856363725854","title":"Acetylation and polyamine metabolism","description":"The top GO terms cluster around acetylation processes (peptidyl-lysine N6-acetylation, N-terminal peptidyl-glutamic acid acetylation, spermine acetylation) and polyamine-related metabolism (putrescine catabolic process, arginine biosynthetic pathway), with related acetylation-related metabolism like N-acetylglucosamine and mycothiol biosynthesis. While a couple terms (angiogenesis, leaf formation) are more plant/animal-oriented and less directly connected, the core signal points to proteins involved in acetylation and polyamine pathways, supporting a label like \u201cAcetylation and polyamine metabolism.\u201d ","confidence":"Medium","size":18,"edges":102,"triangles":312,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":12},{"id":"GO:0006348","count":9},{"id":"GO:0018003","count":9},{"id":"GO:0018002","count":8},{"id":"GO:0009447","count":8}]},{"hash":"276687786168861008","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034474","count":2},{"id":"GO:0044387","count":2},{"id":"GO:0008033","count":2},{"id":"GO:1900369","count":2},{"id":"GO:0035087","count":2}]},{"hash":"826004042338412971","title":"Diverse Substrate Membrane Transporters","description":"Most of the top GO terms describe transmembrane transport across membranes for a variety of substrates (potassium, sodium, galactose, nitrite/nitrate, vitamins, and other compounds). This suggests the cluster is enriched for membrane transporter proteins with broad substrate specificity. An outlier term (mRNA splicing) does not align with the transport theme, so the label emphasizes the transport function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0098700","count":2}]},{"hash":"894833608683344681","title":"Translation initiation and viral translation regulation","description":"The most frequent GO terms describe translation initiation, preinitiation complex formation, translation reinitiation, and IRES-dependent viral translation, pointing to a group involved in the initiation machinery and viral translation control. A couple non-related terms appear as noise but do not override the dominant theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1797405441668418154","title":"Rho GTPase Signaling and Cytoskeletal Regulation","description":"The cluster centers on regulation of Rho signaling and GTPase activity, with frequent mentions of actin cytoskeleton dynamics, ERK signaling, cell polarity, sarcomere organization, adhesion, and mitotic spindle components. These together point to coordinated control of cytoskeletal remodeling and associated signaling pathways during cell shape changes, division, and adhesion. ","confidence":"High","size":18,"edges":71,"triangles":78,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0071963","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0090307","count":2}]},{"hash":"603453443722350663","title":"ER-Golgi secretory trafficking and Wnt secretion","description":"This cluster is defined by terms for ER-to-Golgi transport, COPI vesicle formation/budding, Golgi ribbon formation, and promoting protein exit from the ER, plus Wnt secretion, pointing to a core secretory pathway for secreted proteins.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001893","count":1},{"id":"GO:0007311","count":1},{"id":"GO:0090161","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0048205","count":1}]},{"hash":"525180916705510982","title":"Neural signaling and visual system development","description":"The cluster is dominated by terms tied to neural signaling and visual function: excitatory postsynaptic potential, neuronal drug responses (cocaine, ethanol), optic nerve morphogenesis, and visual learning. These point to synaptic activity and visual system development as the core theme, with other terms like DNA replication and proliferation regulation likely reflecting broader cellular processes in neural cells. Confidence: High","confidence":"","size":18,"edges":19,"triangles":4,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":17},{"id":"GO:0042220","count":17},{"id":"GO:1901214","count":17},{"id":"GO:0071361","count":17},{"id":"GO:0021631","count":17}]},{"hash":"231378239097482941","title":"Angiogenesis and immune-vascular signaling","description":"The cluster is centered on vascular development and remodeling, with strong signals for angiogenesis, endothelial cell migration, and cell-matrix adhesion, complemented by immune components (complement activation via lectin pathway, adaptive immune response) and coagulation-related processes (platelet activation, vasoconstriction). The ERK1/2 cascade acts as a key signaling hub linking these cues to vascular and immune responses, suggesting a cohesive module where angiogenesis is intertwined with immune and coagulation signaling. The locomotory exploration term is less central but may reflect organismal behavioral context of these pathways. Overall, this label captures a vascular-immune-angiogenesis\u2013related module.","confidence":"High","size":18,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0070374","count":7},{"id":"GO:0001525","count":6},{"id":"GO:0035641","count":5},{"id":"GO:0002250","count":5}]},{"hash":"872646204738592219","title":"Embryonic organ morphogenesis","description":"These terms cluster around development and formation of organs, including kidney, liver, and heart structures (endocardium and outflow tract morphogenesis), as well as left-right asymmetry. Signaling pathways such as BMP and ephrin signaling are linked to morphogenesis; a single term about N-glycan processing is less specific. Overall, the cluster centers on embryonic organ development and morphogenesis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072001","count":1},{"id":"GO:0010977","count":1},{"id":"GO:0006491","count":1},{"id":"GO:0001889","count":1},{"id":"GO:0003151","count":1}]},{"hash":"1938922452879331694","title":"Pain and Mechanosensory Perception","description":"The term set centers on nociception and detection of mechanical, chemical, and temperature stimuli implicated in pain, including mechanosensory behavior. Additional terms about synaptic activity regulation and ion homeostasis support a neuronal signaling context, aligning with pain pathways.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":2},{"id":"GO:0050968","count":2},{"id":"GO:0050965","count":1},{"id":"GO:0046929","count":1},{"id":"GO:0060025","count":1}]},{"hash":"2157019733420243221","title":"Synaptic vesicle trafficking and synapse formation","description":"This cluster is dominated by GO terms related to synapse assembly and synaptic plasticity (e.g., long-term potentiation, dendritic spine development) along with processes of membrane trafficking (endocytosis, intracellular transport, acrosome reaction). Together these suggest proteins involved in vesicle cycling and membrane fusion that underpin synaptic development and function, with broader links to cell polarity and protrusion dynamics seen in mating projection growth. ","confidence":"Medium","size":18,"edges":149,"triangles":755,"max_degree":17,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0031384","count":3},{"id":"GO:0010796","count":3},{"id":"GO:0007416","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0006886","count":3}]},{"hash":"2274230673414581065","title":"Vesicle Exocytosis and Rho Signaling","description":"The cluster\u2019s top GO terms point to regulation of exocytosis (dense core granule and synaptic vesicle exocytosis) and Rho protein signal transduction, suggesting a shared theme of controlling vesicle trafficking via cytoskeletal dynamics. Additional terms related to apoptosis and stress signaling support a broader cell-survival context, with some representation of membrane-associated processes like sterol biosynthesis and centriole elongation that may reflect connected growth or membrane remodeling programs. Overall, the exocytosis/cytoskeleton regulation theme best ties the dominant terms together.","confidence":"Medium","size":18,"edges":101,"triangles":213,"max_degree":14,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0043065","count":6},{"id":"GO:1905415","count":5},{"id":"GO:0032443","count":5},{"id":"GO:0061511","count":5}]},{"hash":"684049797997255178","title":"Ribosome Biogenesis and Translation Machinery","description":"Most terms relate to ribosome production and use in translation: ribosome biogenesis, ribosomal subunit export from the nucleus, translational initiation/termination, ribosome disassembly, and maturation of SSU-rRNA, with a note on nuclear pore complex assembly and mRNA capping. The cluster thus seems to represent proteins involved in assembling ribosomes and mediating translation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0000054","count":1},{"id":"GO:0006415","count":1},{"id":"GO:0060702","count":1},{"id":"GO:0032790","count":1}]},{"hash":"1302435511302232453","title":"Immune signaling and antiviral responses","description":"The cluster features multiple immune-related GO terms, notably B cell receptor signaling, lipopolysaccharide-mediated signaling, cellular response to LPS, positive regulation of interferon-beta production, and response to exogenous dsRNA, pointing to immune and antiviral signaling activity. There are also neural development terms (axonogenesis, corpus callosum development) and a broad Rho signaling component, suggesting some multifunctional or pleiotropic roles. Overall, the dominant theme appears to be immune signaling with additional neural development signals as potential secondary associations.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0035249","count":3},{"id":"GO:0031663","count":3}]},{"hash":"1525553391016296533","title":"Neuroendocrine-Immune Signaling","description":"Top GO terms point to both neuromodulatory pathways (MAPK-activating adrenergic signaling; dopamine receptor signaling) and immune/xenobiotic responses (lipopolysaccharide response; IL-6 production; histamine response; xenobiotic stimulus), plus related tissue functions (heart development; saliva secretion). The cluster seems to group proteins involved in neuroendocrine regulation that modulate immune/inflammatory responses rather than a single precise pathway, justifying the label Neuroendocrine-Immune Signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0032675","count":2},{"id":"GO:0046541","count":2}]},{"hash":"240167477131184251","title":"Multisystem Development and Differentiation","description":"The top GO terms cluster around developmental processes across multiple tissues (brain development, neuron migration and forebrain neuron type commitment; gonad, cartilage, pharyngeal system development; mast cell differentiation; adaptive immune response) plus a note on transcriptional regulation. This suggests a broad role in developmental differentiation rather than a single, coherent pathway, hence a general developmental/differentiation label. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0021902","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0001764","count":3}]},{"hash":"2171222438639917036","title":"Vertebrate Developmental Processes","description":"This cluster is enriched for GO terms spanning embryogenesis and organogenesis across multiple tissues (eye retina, heart, lung, mammary/nipple, etc.). Terms like retina development, in utero embryonic development, heart development, and visual perception indicate broad developmental roles, while transcriptional regulation and mRNA splicing reflect general gene-expression control common during development. Overall, the common theme is diverse vertebrate developmental processes rather than a single tissue-specific function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0007626","count":3}]},{"hash":"119583322537593461","title":"Retina Development and Melanosome Transport","description":"The proteins in this cluster repeatedly map to eye-related functions (retina development, visual perception, retina vasculature development) and pigment-cell trafficking (endosome to melanosome transport; exocytosis), with supporting roles in cell junctions and signaling relevant to retinal tissue organization. This combination suggests a shared theme around retina development and pigment/vesicle transport, justifying the label.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000009","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0006887","count":2},{"id":"GO:0061298","count":2},{"id":"GO:0090528","count":2}]},{"hash":"555139128043531492","title":"Developmental morphogenesis and basement membrane formation","description":"The GO terms cluster around tissue development (intramembranous ossification, chondrocyte/endodermal differentiation, skin morphogenesis) and extracellular matrix/basement membrane assembly (integrin biosynthetic process, glomerular basement membrane development). These shared themes point to roles in developmental morphogenesis and ECM remodeling, with a few related terms (lipoprotein clearance, complement activation) appearing less central. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034381","count":1},{"id":"GO:0003431","count":1},{"id":"GO:2000534","count":1},{"id":"GO:0001957","count":1},{"id":"GO:2000481","count":1}]},{"hash":"1485250674549261247","title":"Rab/Rap GTPase-driven endosomal trafficking","description":"This cluster is dominated by GO terms for Rap signaling, Rab GTPase regulation, and various endosomal transport steps (plasma membrane to endosome, late endosome to Golgi), suggesting a cohesive role in small GTPase\u2013driven vesicle trafficking. A few terms related to mRNA splicing and nuclear maintenance appear but are less connected to the main trafficking theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032486","count":3},{"id":"GO:0090630","count":2},{"id":"GO:0048227","count":2},{"id":"GO:0032483","count":2},{"id":"GO:0034499","count":2}]},{"hash":"2034730791072559667","title":"SNARE-Mediated Vesicle Transport","description":"The cluster centers on membrane trafficking and membrane fusion processes: SNARE complex assembly, intra-Golgi and endosome-to-Golgi transport, vesicle fusion events including exocytosis and neurotransmitter receptor insertion, and autophagosome docking. These together point to a cohesive theme of vesicle trafficking and SNARE-driven membrane fusion, with a secondary note of membrane transport activities like ion translocation. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0048280","count":1},{"id":"GO:0043320","count":1},{"id":"GO:0006891","count":1},{"id":"GO:0098967","count":1}]},{"hash":"2056409506767408110","title":"Unknown","description":"The GO terms are highly heterogeneous and there is no shared biological process or pathway linking the 18 proteins; terms include redox homeostasis, corneocyte development, aging, mRNA stability, phosphatidylinositol dephosphorylation, DNA repair, recombination, and glycogen regulation\u2014each representing distinct processes. With no network edges linking the proteins, a single coherent function label cannot be assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":1},{"id":"GO:0014912","count":1},{"id":"GO:0003335","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0043488","count":1}]},{"hash":"1110396662562813391","title":"Embryonic tissue morphogenesis and placental development","description":"This cluster shows GO terms centered on embryonic development and tissue morphogenesis, including cartilage and collagen organization, heart-related EMT in endocardial cushion formation, placental/trophoblast development, and left-right patterning. A few terms (like innate immune response and palmitoylation) are more peripheral but do not override the overall developmental theme. Confidence: Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0060536","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1}]},{"hash":"738883880827802991","title":"Unknown","description":"The GO terms are extremely diverse and largely non-overlapping, spanning neural retina development, seed dormancy maintenance, root meristem identity, cell growth regulation, epigenetic processes (nucleosome disassembly/mobilization), jasmonic acid signaling, and even host-mediated viral transcription. Several terms are obsolete, and there are no edges or functional modules linking the proteins. Because there is no coherent shared function or pathway for the cluster, a specific label cannot be inferred.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043923","count":1},{"id":"GO:0044109","count":1},{"id":"GO:1900400","count":1},{"id":"GO:0003407","count":1},{"id":"GO:0010231","count":1}]},{"hash":"1470420287631450719","title":"Bacterial metabolism and biosynthesis","description":"The proteins show enrichment across diverse metabolic and biosynthetic processes (amino acid catabolism/biosynthesis, fatty acid oxidation, lipid and cofactor biosynthesis like menaquinone and phylloquinone, L-serine/L-valine pathways, LPS biosynthesis, and TCA cycle), suggesting a cohesive role in bacterial central metabolism and biosynthetic capacity. Confidence: High","confidence":"","size":17,"edges":94,"triangles":290,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0009103","count":4},{"id":"GO:0006635","count":4},{"id":"GO:0006574","count":4},{"id":"GO:0009234","count":4}]},{"hash":"458318150232140366","title":"Transcriptional Regulation and Translation Initiation in Development","description":"This cluster centers on gene expression control, with several GO terms for transcription regulation (DNA-templated transcription, negative regulation of transcription by RNA Pol II) and multiple development-related terms (brain, heart development, lens fiber differentiation). It also includes translation-related steps (translation reinitiation, preinitiation complex formation) and a ubiquitination term, suggesting coordinated regulation of transcription and translation during development and stress responses (cadmium). Overall, the proteins appear to function in developmental gene regulation with translational control components.","confidence":"Medium","size":17,"edges":22,"triangles":9,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0071276","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0070306","count":3},{"id":"GO:0000122","count":3}]},{"hash":"2270634904486000177","title":"Spinal motor neuron development and axon guidance","description":"Dominant GO terms point to motor neuron development, axonogenesis, axon guidance, and spinal cord motor neuron fate specification, suggesting a cohesive function in motor neuron development and pathfinding; additional terms like cell-matrix adhesion may reflect guidance cues and migratory context.","confidence":"High","size":17,"edges":121,"triangles":483,"max_degree":16,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048936","count":7},{"id":"GO:0008045","count":7},{"id":"GO:0097477","count":7},{"id":"GO:0070527","count":7},{"id":"GO:0007160","count":7}]},{"hash":"150539546494281859","title":"RNA processing and ribosome biogenesis","description":"The cluster is dominated by RNA metabolism and ribosome-related terms, including ribosome biogenesis, transcription/translation initiation components, mRNA splicing via spliceosome, mRNA export, and ncRNA-mediated gene silencing, indicating a cohesive module around RNA processing and protein synthesis machinery.","confidence":"Medium","size":17,"edges":6,"triangles":2,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0001731","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":5}]},{"hash":"2031563006359089478","title":"Regulation of Axon Guidance and Neuronal Migration","description":"This cluster is dominated by GO terms tied to axon guidance and neuronal migration, including retinal ganglion and motor neuron axon guidance, tangential migration of olfactory bulb interneurons, chemorepulsion, and paranodal/juxtaparanodal region localization. The mix of guidance, migration, and synapse maturation terms suggests proteins that regulate axon pathfinding and related neuronal development processes. ","confidence":"High","size":17,"edges":54,"triangles":38,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090260","count":10},{"id":"GO:0070100","count":10},{"id":"GO:0071672","count":10},{"id":"GO:0030913","count":10},{"id":"GO:0045463","count":10}]},{"hash":"499285755513140020","title":"Neural signaling and vision development","description":"The top GO terms cluster around neurotransmitter handling and synaptic vesicle exocytosis, i.e., neuronal signaling, and include vision-related terms like visual perception and retina development. While there are a few junction and secretion-related terms, the dominant themes are neural communication and eye/retina development, supporting this label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030073","count":1},{"id":"GO:0031915","count":1},{"id":"GO:0006836","count":1},{"id":"GO:0016079","count":1},{"id":"GO:0046928","count":1}]},{"hash":"1096362207320647493","title":"Fibrinolysis and Tissue Remodeling","description":"This cluster is dominated by fibrinolysis and plasminogen activation signals, with related processes in extracellular matrix remodeling and epithelial morphogenesis (adhesion regulation, apical constriction, mammary duct growth, keratinocyte differentiation). There are additional links to cell-cycle control and immune signaling (IL-10), but the central theme appears to be proteolytic remodeling of tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031639","count":3},{"id":"GO:1902042","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0010812","count":2},{"id":"GO:0007050","count":2}]},{"hash":"115360525400942397","title":"Adaptive immune signaling and T cell regulation","description":"Dominant terms point to adaptive immune processes: positive regulation of canonical NF-kappaB signaling, T cell homeostasis, and T follicular helper cell differentiation. While a few terms touch on nociception or hormone metabolism, the most representative cluster theme is immune signaling and T cell biology, justifying the name. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0050968","count":2},{"id":"GO:1903244","count":2},{"id":"GO:0050966","count":2}]},{"hash":"720816704075173383","title":"Epigenetic regulation of development","description":"Most terms point to chromatin regulation (histone exchange, nucleosome mobilization, histone acetylation, transcription initiation) and to developmental signaling pathways (Wnt/PCP, TGF-beta) and segment specification, suggesting a cluster of proteins involved in controlling gene expression during development via epigenetic mechanisms.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0048510","count":1},{"id":"GO:0042766","count":1},{"id":"GO:0006348","count":1}]},{"hash":"1480933107532175968","title":"Unknown","description":"GO terms are spread across multiple developmental contexts (cartilage morphogenesis, placental/embryonic development, endocrine system development, left-right pattern formation, pancreatic cell development) and include metabolic/lysosomal processes (gluconeogenesis regulation, protein catabolic process in the vacuole), with no single cohesive function dominating. This lack of a unifying theme supports labeling the cluster as Unknown.","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0003323","count":1}]},{"hash":"2090788096185906593","title":"Translation Initiation and Regulation","description":"This cluster centers on eukaryotic translation initiation and its control, with terms for IRES-dependent initiation, regulation of translational initiation, preinitiation complex formation, and eIF4F assembly, plus translation reinitiation. Some associated terms reflect broader post-transcriptional control of mRNA translation (e.g., miRNA-mediated silencing), collectively indicating a cohesive group of proteins involved in initiating and regulating protein synthesis, including viral contexts.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075522","count":10},{"id":"GO:0006446","count":10},{"id":"GO:0075525","count":10},{"id":"GO:0002188","count":10},{"id":"GO:0001731","count":10}]},{"hash":"2256654752043590162","title":"Cytoskeleton Remodeling and Intracellular Transport","description":"This cluster is driven by terms related to microtubule and actin organization and movement, including mitotic spindle assembly, spindle midzone, actin crosslinking, terminal web formation, and plus-end\u2013directed transport. The inclusion of dendritic transport and Purkinje cell layer structure suggests neuronal contexts, while chloroplast movement reflects plant cytoskeletal\u2013mediated transport. Together, the proteins appear to share a core function in cytoskeletal dynamics and intracellular cargo movement across diverse cell types.","confidence":"High","size":17,"edges":43,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0051764","count":2},{"id":"GO:1902896","count":2},{"id":"GO:0098971","count":1},{"id":"GO:0009904","count":1}]},{"hash":"504765049400092280","title":"Ubiquitination and Proteasomal Degradation","description":"The top GO terms point strongly to ubiquitin-related processes (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein polyubiquitination, K11-linked ubiquitination) and degradation via the proteasome (ubiquitin-dependent ERAD pathway), indicating this cluster centers on protein ubiquitination and proteasomal turnover, with related roles in cell cycle and chromatin regulation as downstream effects.","confidence":"High","size":17,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0071276","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0070979","count":4}]},{"hash":"1499091161135701881","title":"Translational Regulation in Spermatogenesis","description":"The cluster shows strong signals for translation and its control (translation, cap-dependent initiation, negative regulation of translation) together with germ cell\u2013specific processes (spermatid differentiation, male meiosis cytokinesis), indicating a coordinated role of protein synthesis control during spermatogenesis. Additional terms related to apoptosis and autophagy regulation, and stem cell maintenance, suggest broader quality-control and developmental dynamics within germ cells. Some other terms may reflect shared components across cell types, but the prevailing theme ties translation control to germ cell differentiation.","confidence":"Medium","size":17,"edges":17,"triangles":7,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0048515","count":1},{"id":"GO:0007112","count":1},{"id":"GO:0045665","count":1}]},{"hash":"255076957485988516","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":1},{"id":"GO:0034414","count":1},{"id":"GO:0034247","count":1},{"id":"GO:0017001","count":1},{"id":"GO:0006364","count":1}]},{"hash":"1876719548131155492","title":"Developmental differentiation and tissue morphogenesis","description":"This cluster centers on diverse developmental and differentiation processes across multiple tissues (nephron differentiation, hair plane orientation, B cell differentiation, blood vessel maturation, synapse assembly, axis specification), with a few more general cellular functions like protein folding and cell cycle regulation. The shared theme appears to be development and organization of tissues rather than a single specific pathway, though the terms span multiple organ systems. ","confidence":"Medium","size":17,"edges":69,"triangles":106,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":2},{"id":"GO:0006457","count":2},{"id":"GO:1905323","count":2},{"id":"GO:0045317","count":1},{"id":"GO:0048105","count":1}]},{"hash":"2277595728568385798","title":"Unknown","description":"The terms span RNA processing (tRNA transcription by RNA Pol III; spliceosomal assembly) to diverse developmental and immune functions (auditory receptor development, endothelial adhesion, various immune antigen presentation and cytokine activities). There is no clear, unified functional theme connecting the majority of terms, and the cluster appears compositionally heterogeneous, so a single descriptive label is not supported.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":2},{"id":"GO:0042797","count":2},{"id":"GO:0000387","count":1},{"id":"GO:0000245","count":1},{"id":"GO:0035260","count":1}]},{"hash":"797361638313960304","title":"Ubiquitin-Dependent NF-\u03baB Signaling","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes and activation of NF-kappaB signaling (including TNF-mediated signaling and IKK activity), pointing to a core role in ubiquitin-regulated immune/inflammatory signaling pathways. While some terms touch on chromatin modification and V(D)J recombination, these can be linked to ubiquitin-mediated regulation of transcription and immune cell development, supporting a cohesive label around ubiquitin-driven NF-\u03baB signaling in immune responses.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:1901253","count":15},{"id":"GO:0033209","count":15},{"id":"GO:1903762","count":15},{"id":"GO:0007250","count":15}]},{"hash":"1309487119584193921","title":"Sugar Catabolism Cluster","description":"The top GO terms are dominated by carbohydrate catabolic processes (glucose, galactose, xylitol, furaldehyde) and related steps (pyruvate fermentation to ethanol, other sugar metabolism). There are a few unrelated terms (nitrosative stress, apoptotic process), but the strongest signal ties to sugar metabolism and energy-yielding pathways, suggesting this cluster centers on carbohydrate breakdown. The lack of edges implies limited direct interactions among members or annotation noise, but the shared theme is metabolic processing of sugars.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0055114","count":1},{"id":"GO:0051160","count":1},{"id":"GO:0043458","count":1},{"id":"GO:0019595","count":1}]},{"hash":"56203268394968386","title":"Embryonic development and organ morphogenesis","description":"Top terms indicate embryonic development and morphogenesis of multiple organs (eye, heart, ovary, prostate, brain region habenula) along with transcriptional regulation during development. The common theme is embryonic organogenesis and tissue differentiation, so the cluster is best described as Embryonic development and organ morphogenesis.","confidence":"High","size":17,"edges":80,"triangles":183,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":12},{"id":"GO:0001701","count":11},{"id":"GO:0055010","count":10},{"id":"GO:0001547","count":10},{"id":"GO:0060528","count":10}]},{"hash":"1610418334035710022","title":"Cytoskeletal dynamics and barrier regulation","description":"The top terms converge on cytoskeletal organization (microvillus assembly, stress fiber regulation) and signaling pathways (Rac, cGMP, PKA) with processes related to barrier function in endothelial/epithelial contexts (endothelial intestinal barrier, glomerulus development). This suggests a cluster of proteins that modulate cell shape, adherence, and signaling to regulate barrier properties, rather than a single enzymatic process. Therefore, a label focused on cytoskeletal dynamics and barrier regulation best captures the shared theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030033","count":3},{"id":"GO:0051497","count":3},{"id":"GO:0035021","count":3},{"id":"GO:2000481","count":2},{"id":"GO:2000670","count":2}]},{"hash":"1294900858605296066","title":"Prostaglandin-driven inflammatory and detoxification response","description":"The cluster shows strong enrichment for prostaglandin biosynthesis, a hallmark of inflammatory signaling, along with multiple detoxification and stress-related processes (oxidant detoxification, glucocorticoid response, ethanol/ascorbic acid responses, nitrogen detoxification) and regulation of immune-related pathways, suggesting a coordinated inflammatory and detoxification/state-stress function.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":15},{"id":"GO:0042994","count":13},{"id":"GO:0098869","count":13},{"id":"GO:2000429","count":13},{"id":"GO:2001237","count":13}]},{"hash":"1017116906213743854","title":"Dopaminergic signaling and neural plasticity","description":"This cluster centers on dopaminergic synaptic transmission, cocaine-related behavioral responses, ERK signaling, calcium mobilization, and sensory processing (vision and pain), suggesting a dopamine-driven neural signaling and plasticity program.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0048148","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0008542","count":3},{"id":"GO:0008285","count":3}]},{"hash":"1352445195564876339","title":"Drosophila neuroblast and germline development","description":"This cluster\u2019s terms cluster around neural progenitor proliferation (neuroblasts), germarium-derived oocyte differentiation, neuronal stem cell maintenance, and related neural/germline development processes in Drosophila, with supporting signals like Wnt pathway regulation and microtubule nucleation. The common theme is developmental programs governing progenitor cell proliferation and differentiation in neural and germline lineages, making a development-focused label appropriate.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030037","count":1},{"id":"GO:0007282","count":1},{"id":"GO:0002052","count":1},{"id":"GO:0021873","count":1},{"id":"GO:0097150","count":1}]},{"hash":"808570993351510198","title":"Neural development and synaptic localization","description":"These proteins show terms tied to brain and spinal cord development and synaptic receptor localization, pointing to neural differentiation and synaptic function as the core theme. However, several top terms reflect general cellular machinery (ER-Golgi transport, ribosome biogenesis/export, mRNA splicing), so the neural development signal is plausible but not exclusive. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0000398","count":2}]},{"hash":"2256435276419375624","title":"Neural development and organ morphogenesis","description":"These terms center on developmental processes (embryogenesis, organ morphogenesis) and neural patterning, with several signaling pathways (Hedgehog/SMO, VEGF-PDGFR, FGF). The common thread is developmental regulation and tissue morphogenesis, including neural wiring, rather than a specific tissue.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060484","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0090272","count":3},{"id":"GO:0035260","count":2}]},{"hash":"1325559714860990892","title":"Cytokine regulation and GPCR signaling","description":"Top GO terms point to immune modulation (regulation of IL-6 and IL-1\u03b2 production, eosinophil chemotaxis) alongside GPCR-driven signaling (adrenergic, histamine, dopamine receptors; activation of adenylate cyclase; MAPK activation). This suggests a theme of coordinated cytokine regulation with GPCR-mediated signal transduction, rather than a single highly specific process. ","confidence":"Medium","size":17,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032675","count":1},{"id":"GO:0046541","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0071883","count":1},{"id":"GO:0034776","count":1}]},{"hash":"1800408355419291998","title":"Innate Immune Signaling and Cytokine Regulation","description":"The top GO terms cluster around innate immune pathways: TLR signaling (TLR8, LPS), NF-kB activation (I-kappaB phosphorylation), and cytokine/interferon production (type II IFN, IFN-\u03b1), plus regulation of cytokine and chemokine signaling. This points to a cohesive function in innate immune responses and cytokine regulation; a minor mention of Wnt signalosome assembly may reflect cross-talk but is not the dominant theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046426","count":4},{"id":"GO:0090260","count":4},{"id":"GO:0007252","count":4},{"id":"GO:0034158","count":4},{"id":"GO:0045078","count":4}]},{"hash":"895033821694863663","title":"GTPase-regulated polarity and vesicle trafficking","description":"This cluster centers on small GTPase signaling and a network of vesicle trafficking and membrane organization: regulation of GTPase activity, endosome-to-lysosome and endosome-to-plasma membrane transport, exocytosis, and lysosomal membrane organization, plus epithelial polarity and podosome assembly. Together they suggest a role in coordinating cytoskeletal dynamics with targeted vesicle trafficking to establish or maintain cell polarity. The floral organ abscission term appears as an outlier from plant biology and does not strongly alter the overall theme.","confidence":"Medium","size":17,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0090162","count":5},{"id":"GO:0030037","count":4},{"id":"GO:1902824","count":4},{"id":"GO:0071803","count":4}]},{"hash":"334116606396970395","title":"Unknown","description":"The top GO terms span neural vesicle endocytosis regulation, circadian rhythm, muscle and retina development, multicellular development, and various transmembrane transport processes (glucose, biotin, myo-inositol, sodium). There are no edges or apparent clustering structure, suggesting no single shared function tying these proteins together. Therefore, a precise, cohesive label isn\u2019t supported; the cluster is Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:0043046","count":2},{"id":"GO:0042748","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1401909527176452856","title":"Serotonin/Dopamine signaling and neural development","description":"This cluster centers on GO terms tied to neurotransmitter handling (serotonin uptake, serotonin secretion regulation, dopamine catabolic process) and neural development (thalamus and adenohypophysis development, glial growth). The mix suggests proteins involved in neuronal signaling and brain development rather than a single pathway, yielding a label that captures the common theme. The zero edges indicate no direct interaction data in this set, but the GO terms collectively point to neural communication and development.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0015824","count":1},{"id":"GO:0014064","count":1},{"id":"GO:1905847","count":1},{"id":"GO:1903346","count":1}]},{"hash":"761232032462888321","title":"Embryonic Morphogenesis and Neural Development","description":"The proteins in this cluster are enriched for embryonic development and morphogenesis across multiple organs (eye, brain, neural crest, branching morphogenesis in lung/ureteric bud, digestive tract). The presence of transcription by RNA polymerase II indicates broad transcriptional activity during development, supporting a cohesive theme of embryonic organ formation and neural development.","confidence":"High","size":17,"edges":3,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043010","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0060441","count":9},{"id":"GO:0006366","count":9},{"id":"GO:0048557","count":9}]},{"hash":"1112488388946644041","title":"Vacuolar amino acid and ion transport","description":"Most of the top GO terms point to transport processes of amino acids (L-alanine, proline, histidine) and serine into the vacuole, as well as lithium ion transport, suggesting a cluster enriched for vacuolar transport activities. A few terms relate to transcription, but these appear peripheral and do not tie the cluster together as clearly as the transport signals. Therefore, \"Vacuolar amino acid and ion transport\" seems like the most representative label for this cluster.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043433","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0090516","count":2},{"id":"GO:0090452","count":2}]},{"hash":"484120696056576544","title":"Rho-regulated Filopodia and Endosomal Transport","description":"This cluster is driven by GO terms pointing to cytoskeletal remodeling and membrane trafficking: filopodium assembly, cell migration, and endosomal transport, all linked through regulation of Rho signaling and related pathways. Additional terms related to mRNA processing or lineage-specific cardiac development appear less central, but the dominant theme is actin-driven protrusions and endocytosis that facilitate cell movement and cargo trafficking.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":2},{"id":"GO:0016197","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0048549","count":2},{"id":"GO:0006397","count":2}]},{"hash":"1579101558057309126","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902570","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0035385","count":2}]},{"hash":"129794089846717822","title":"Developmental morphogenesis and organogenesis","description":"The top GO terms cluster around embryonic tissue shaping, gastrulation movements, organ formation, and cadherin-mediated adhesion, indicating a shared role in morphogenesis and organogenesis; a few terms about steroid biosynthesis may reflect broader developmental signaling contexts rather than a core function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":1},{"id":"GO:0006702","count":1},{"id":"GO:0061332","count":1},{"id":"GO:0060029","count":1},{"id":"GO:0032349","count":1}]},{"hash":"1387622053725258160","title":"Developmental Signaling and Immune Processes","description":"The terms point to a mix of developmental roles (heart development, megakaryocyte development, developmental pigmentation) and signaling pathways (regulation of Rho signaling, PI3K/PLC activity) along with innate immune response and synapse organization, suggesting proteins involved in broad developmental signaling with immune-related regulation rather than a single, tightly focused function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0048070","count":3},{"id":"GO:0035855","count":3},{"id":"GO:0051092","count":3}]},{"hash":"1492781134313301241","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0000472","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0042255","count":1},{"id":"GO:0000480","count":1}]},{"hash":"194929929430556856","title":"Eye development and visual perception","description":"The terms converge on ocular biology: retina vasculature development, visual perception, and endosome-to-melanosome transport in pigment cells, pointing to the eye/retina. Some items (Notch signaling regulation, microglia development, junction assembly) can contribute to retinal development and tissue organization, but the eye/visual system remains the strongest shared theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0007601","count":1}]},{"hash":"691048667315713286","title":"Ubiquitin-Proteasome\u2013Mediated Antiviral Defense","description":"The cluster is driven by GO terms linking innate immune response and defense against viruses, together with ubiquitin\u2013proteasome\u2013system processes (SCF-dependent ubiquitination, deubiquitination, and ERAD-related turnover). This suggests a functional theme around protein quality control and ubiquitin signaling that supports antiviral defenses, even though a few terms (mRNA processing or behavior) may be incidental.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051607","count":2},{"id":"GO:1904378","count":1}]},{"hash":"1168845951388479311","title":"Neural development and brain region specification","description":"This cluster\u2019s top GO terms center on neural development and brain patterning, including midbrain and brain development as well as interneuron differentiation (e.g., GABAergic interneuron differentiation and subpallium neuron fate commitment). While a few terms refer to other organ development (placenta, bronchiole), the dominant signal is neural development and regional specification.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0007626","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0048839","count":6}]},{"hash":"535521115221757327","title":"DNA Repair and Oxidative Stress Response","description":"This cluster centers on DNA maintenance activities (base-excision repair, DNA recombination) alongside cellular responses to oxidative stress (hydrogen peroxide response, redox homeostasis). While a few terms are less directly related (corneocyte development, aging, mRNA stability), the dominant signals point to genome maintenance under oxidative conditions.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":5},{"id":"GO:0070301","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0014912","count":4},{"id":"GO:0003335","count":4}]},{"hash":"47929864812258081","title":"Unknown","description":"The cluster\u2019s top GO terms are diverse (redox homeostasis, corneocyte development, RNA stability regulation, base-excision repair, DNA recombination, lipid signaling, and glycogen regulation) with no single dominant function. This lack of a cohesive biological theme makes a concise, specific label difficult, so the safe choice is Unknown.","confidence":"","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":12},{"id":"GO:0014912","count":12},{"id":"GO:0003335","count":12},{"id":"GO:0007568","count":12},{"id":"GO:0043488","count":12}]},{"hash":"1717854023172313319","title":"Ubiquitin-Mediated Regulation of Muscle and Immune Processes","description":"Several top GO terms center on ubiquitin-dependent protein degradation and ubiquitination, suggesting a core regulatory module. Additionally, terms related to skeletal muscle development/differentiation and immune functions (B cell signaling, germinal center formation) point to a link between ubiquitin regulation and muscle-immune processes, with circadian rhythm involvement also present. The lack of edges means the cluster is a heterogeneous collection sharing a theme of ubiquitin-mediated regulation across muscle and immune contexts.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0042752","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0000209","count":3}]},{"hash":"1578472616211859028","title":"Embryonic Development and Organ Morphogenesis","description":"The top GO terms point to embryonic tissue formation and patterning, including placental (trophoblast differentiation, placenta/endocrine development), heart-related (endocardial EMT), skeletal/cartilage morphogenesis, and left-right patterning. This suggests a cohesive theme of embryonic development and organ morphogenesis, despite a few auxiliary terms (e.g., splicing, ribosomal export). ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2}]},{"hash":"1163688112812455942","title":"Deubiquitinases (DUBs)","description":"The Top Terms are centered on protein deubiquitination across multiple linkages (K48, K11, K63) and ubiquitin-dependent proteolysis, with only a few peripheral terms related to signaling or development. This strongly indicates a cluster of DUB enzymes/regulation, so a label focusing on deubiquitination is appropriate and specific.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071108","count":2},{"id":"GO:0035871","count":2},{"id":"GO:2000349","count":1},{"id":"GO:0070536","count":1},{"id":"GO:0071947","count":1}]},{"hash":"1075368606683867416","title":"Ribosome biogenesis and translation machinery","description":"This cluster centers on proteins involved in making and using ribosomes: translation, ribosome biogenesis, cytosolic ribosome assembly, and snoRNP assembly, with supporting roles in mRNA export and transcription. The preponderance of GO terms related to ribosome production and translation suggests a cohesive functional theme around protein synthesis machinery, despite some secondary developmental annotations. ","confidence":"High","size":16,"edges":115,"triangles":496,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006406","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0001824","count":2}]},{"hash":"1352887854007102213","title":"RNA Processing and Stress Response","description":"This cluster centers on post-transcriptional regulation: multiple GO terms highlight mRNA splicing control (both positive and negative via the spliceosome) and mRNA stability in response to stress, along with ncRNA-mediated gene silencing. Additional signals point to stress granule localization and translation initiation machinery (eIF4F assembly) and IRES-dependent translation, suggesting coordinated RNA processing and translation regulation under cellular stress.","confidence":"High","size":16,"edges":116,"triangles":508,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0010610","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0000398","count":5},{"id":"GO:0048025","count":5}]},{"hash":"2047907995174837884","title":"DNA damage response and apoptosis","description":"This cluster is dominated by terms related to DNA maintenance and programmed cell death, including apoptotic process, base-excision repair, and DNA recombination, suggesting a stress-response/damage-control theme. Redox homeostasis and aging terms further support a cellular maintenance/stress context, though several terms (e.g., corneocyte development, regulation of mRNA stability, PI dephosphorylation) are more peripheral. Overall, the strongest coherent signal is DNA damage response coupled with apoptosis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0007568","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0014912","count":3},{"id":"GO:0003335","count":3}]},{"hash":"2102062034913026148","title":"Diverse Biosynthetic Pathways","description":"The top GO terms point to production and modification of a wide array of metabolites\u2014steroids (androgen/estrogen/glucocorticoid biosynthesis), retinoic acid, fatty acid elongation, melanin, phylloquinone catabolism, antibiotic biosynthesis, and poly-hydroxybutyrate biosynthesis\u2014indicating a cluster centered on broad biosynthetic/metabolic processes rather than a single pathway. The presence of an obsolete oxidation-reduction term is a minor note amid diverse synthesis-related terms.","confidence":"Medium","size":16,"edges":9,"triangles":2,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042376","count":4},{"id":"GO:0042438","count":4},{"id":"GO:0006710","count":4},{"id":"GO:0042619","count":4}]},{"hash":"1650579787828133959","title":"Phosphorylation-Driven Signaling Regulators","description":"These proteins cluster around regulation of phosphorylation and kinase activity (peptidyl-threonine/serine/threonine phosphorylation, protein autophosphorylation, GTPase regulation) and ubiquitin-dependent protein turnover, pointing to modulators of signaling pathways rather than core enzymes. The GO terms suggest a focus on developmental signaling, including myoblast differentiation and insect tracheal system morphogenesis, implying these factors help tune growth and tissue formation. The data show no direct interactions, so this is a functional grouping of regulators rather than a network of physical complexes. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010800","count":2},{"id":"GO:0071404","count":2},{"id":"GO:2000060","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0031954","count":2}]},{"hash":"1728370893544295503","title":"Unknown","description":"GO terms are highly diverse and no single biological theme dominates this cluster (pain detection, chromosome telomere localization, actin assembly, oligodendrocyte differentiation, chemokine production, muscle regeneration, dendrite regulation, vitamin D response, calcium transport, and synaptic plasticity). This lack of a coherent shared function makes it impossible to assign a specific, representative label.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":1},{"id":"GO:0070198","count":1},{"id":"GO:0051017","count":1},{"id":"GO:0048709","count":1},{"id":"GO:0071651","count":1}]},{"hash":"2189781673817550023","title":"Amino acid and cofactor biosynthesis","description":"This cluster shows a convergence on biosynthetic and metabolic pathways, including amino acid production/degradation (alanine, aspartate, lysine), vitamin/cofactor synthesis (biotin, cobalamin), heme precursor production (protoporphyrinogen IX), and central carbon metabolism (TCA cycle, oxaloacetate). The shared theme is biosynthesis of essential building blocks and cofactors within core metabolism.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":6},{"id":"GO:0019878","count":6},{"id":"GO:0006099","count":4},{"id":"GO:0006532","count":4},{"id":"GO:0006782","count":4}]},{"hash":"191888549869173853","title":"ER-Golgi Vesicle Transport","description":"The top GO terms are clearly about vesicle trafficking between the ER and Golgi (both directions), indicating a cohesive function in the secretory pathway. Other terms touch on growth and development, but the strongest and most specific signal is ER-Golgi transport, supporting this label as representative of the cluster\u2019s core function.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0007420","count":3}]},{"hash":"1258268146324614205","title":"Cell adhesion and morphogenesis","description":"The terms cluster around cell-ECM adhesion (hemidesmosome assembly, adhesion-dependent spreading), tissue morphogenesis (tracheal growth, lung morphogenesis, planar orientation), and cell migration (neuron migration), with supporting GPCR signaling; collectively they point to proteins coordinating adhesion, polarity, and developmental remodeling. Some outliers (platelet aggregation, antibiotic biosynthesis) may reflect noise in the dataset. ","confidence":"Medium","size":16,"edges":108,"triangles":409,"max_degree":15,"top_function":"wound healing","top_go_terms":[{"id":"GO:0035001","count":6},{"id":"GO:0031581","count":6},{"id":"GO:0034446","count":6},{"id":"GO:0097477","count":6},{"id":"GO:0070527","count":6}]},{"hash":"678196650397016254","title":"DNA Repair and Cell-Cycle Regulation","description":"This cluster is characterized by strong enrichment for DNA repair and cell-cycle related GO terms (base-excision repair, DNA recombination, and positive regulation of G1/S transition), indicating a theme of genome maintenance and progression through the cell cycle. Additional terms related to redox homeostasis and mRNA stability suggest supportive roles in transcript and redox regulation that can influence genome integrity. While there are some outliers (corneocyte development, hemolysis) that may reflect annotation noise or multifunctionality, the most representative signal points to DNA repair and cell-cycle control as the core function of the cluster.","confidence":"Medium","size":16,"edges":30,"triangles":11,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0007568","count":6},{"id":"GO:0006284","count":6},{"id":"GO:1900087","count":6},{"id":"GO:0045454","count":5},{"id":"GO:0014912","count":5}]},{"hash":"1801910186626593699","title":"DNA replication and RNA processing","description":"The top GO terms cluster around core genome maintenance processes (DNA replication, primer synthesis, DNA unwinding, SOS response) and RNA processing/quality control (mRNA splicing via spliceosome, nonsense-mediated decay), with additional signals of gene expression regulation (translation preinitiation complex formation, protein dephosphorylation, GTPase activity regulation). This suggests a nuclear program coordinating DNA replication/repair with RNA processing and translation readiness, hence the label. ","confidence":"Medium","size":16,"edges":28,"triangles":20,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":2},{"id":"GO:0051754","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0048026","count":2}]},{"hash":"166208273279599201","title":"Wnt signaling and neural crest differentiation","description":"The top GO terms are dominated by Wnt signaling entries (canonical Wnt signaling pathway) and neural crest differentiation, with some historical/obsolete Wnt axis specification terms, indicating a developmental/Wnt-crest theme. There are a few unrelated terms (endosome transport, basement membrane development, receptor signaling), but the main signal centers on Wnt pathways and neural crest development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":1},{"id":"GO:1902955","count":1},{"id":"GO:0010800","count":1},{"id":"GO:0032836","count":1},{"id":"GO:2000055","count":1}]},{"hash":"270617348786674851","title":"Neuroinflammation and Neural Development","description":"The top GO terms emphasize immune response (response to lipopolysaccharide, inflammatory response) alongside neural connectivity processes (axon guidance, chemokine signaling, synapse assembly). This suggests proteins in this cluster participate in inflammatory signaling that intersects with neural development and synaptic remodeling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0090260","count":2}]},{"hash":"776345259693876326","title":"Embryonic and Neurodevelopmental Processes","description":"This cluster is dominated by development-related GO terms (multicellular organism development, forebrain and spinal cord development, skeletal system development) and neural-associated transcription and cell-cycle activities, suggesting a cohesive role in development and neurodevelopment. The presence of stress- and apoptosis-related terms may reflect developmental checkpoints and cellular stress responses.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071276","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0007018","count":4},{"id":"GO:0001501","count":4}]},{"hash":"1071307333321704242","title":"Retinal GABAergic Light Signaling","description":"This cluster\u2019s top GO terms center on detection of light stimulus in visual perception and GABA signaling/secretion, which are characteristic of retinal neurons (photoreceptors and GABAergic interneurons) that process light information and modulate signaling with GABA. Other terms like calcium channel transport and adherens junction localization may reflect shared cellular machinery in neural interfaces and barrier tissues, but the strongest common theme is retinal light perception with inhibitory GABA signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050908","count":2},{"id":"GO:0007214","count":2},{"id":"GO:0046037","count":1},{"id":"GO:0061577","count":1},{"id":"GO:0014051","count":1}]},{"hash":"2181854960657443389","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":2},{"id":"GO:2000637","count":2},{"id":"GO:0010586","count":2},{"id":"GO:1903265","count":2},{"id":"GO:1903883","count":2}]},{"hash":"168354981366302043","title":"Embryonic organ and brain morphogenesis","description":"The top GO terms indicate developmental processes across multiple organs and neural structures, including forebrain/midbrain patterning and GABAergic interneuron differentiation, as well as non-neural organ morphogenesis (spleen, bronchioles, digestive tract, cardiovascular). This suggests a broad role in embryonic development and organogenesis rather than a single pathway.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048536","count":9},{"id":"GO:0090009","count":8},{"id":"GO:0021892","count":8},{"id":"GO:0021798","count":8},{"id":"GO:0030901","count":8}]},{"hash":"606799020058080849","title":"DNA Damage Response and Apoptosis","description":"The cluster\u2019s top GO terms are dominated by apoptotic process, base-excision repair, and DNA recombination, all pointing to cellular responses to DNA damage. Additional terms like redox homeostasis and mRNA stability regulation support a broader stress-response context. While some terms (e.g., corneocyte development, smooth muscle migration regulation) are less directly connected, the core signal appears to be DNA damage response and programmed cell death.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":8},{"id":"GO:0045454","count":7},{"id":"GO:0014912","count":7},{"id":"GO:0003335","count":7},{"id":"GO:0007568","count":7}]},{"hash":"435776300385873487","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around developmental processes: mesoderm development, trophoblast giant cell differentiation, cartilage morphogenesis, endocrine system development, and epithelial-to-mesenchymal transition in endocardial cushion formation. While there are some housekeeping terms (RNA splicing and ribosomal export), the developmental signals dominate, suggesting the cluster groups proteins involved in differentiation and morphogenesis rather than a single molecular function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000055","count":1},{"id":"GO:0032298","count":1},{"id":"GO:0060536","count":1}]},{"hash":"2270809892149373501","title":"Embryonic Eye and Neural Patterning Transcription","description":"This cluster is dominated by transcription-related GO terms (RNA polymerase II transcription, DNA-templated transcription) and several embryonic development terms (embryonic eye morphogenesis, rhombomere development, brain segmentation, segment specification). Together these suggest a set of proteins that regulate gene expression programs governing neural/eye patterning during development, with some temporal regulation indicated by circadian-related transcription. The focus on transcriptional control in early development justifies the label.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0045872","count":5},{"id":"GO:0048048","count":4},{"id":"GO:0021571","count":4}]},{"hash":"549910727517798755","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"This cluster is dominated by ubiquitin-dependent protein catabolism (including K48-linked ubiquitination) and NF-\u03baB\u2013related signaling components (TNF-mediated activation, IKK activity). These terms point to coordinated regulation of protein turnover and inflammatory signaling via the ubiquitin-proteasome system. Some ancillary terms about peroxisomal import and chromatin marks appear less central, but do not override the core theme of ubiquitin-mediated regulation of NF-\u03baB pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:1901253","count":7},{"id":"GO:0033209","count":7},{"id":"GO:1903762","count":7},{"id":"GO:1900095","count":7}]},{"hash":"208506516562789376","title":"Symbiont nitrogen metabolism and host immune evasion","description":"This cluster centers on nitrogen-related processes (nitrogen starvation response, nitrogen fixation, nitrogen catabolite repression) and includes a clear link to host interaction via symbiont-mediated immune evasion, suggesting a theme of metabolic regulation in a symbiotic organism coupled with mechanisms to modulate host defenses. Some terms appear less directly connected (glucose response, insulin-related processes), but the dominant signal is nitrogen metabolism alongside host interaction.","confidence":"Medium","size":16,"edges":22,"triangles":17,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010756","count":5},{"id":"GO:0006542","count":5},{"id":"GO:0044044","count":5},{"id":"GO:0032024","count":5},{"id":"GO:0006995","count":5}]},{"hash":"653641583486345760","title":"Unknown","description":"This cluster provides no GO terms, edges, or shared functional signals to infer a common role among the 16 proteins; the only note is that 20 proteins were re-added by ReCIPE, which does not yield a recognizable functional theme.  ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2285845133057882970","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000056","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000447","count":2}]},{"hash":"869135964270379690","title":"Hormone-responsive development and morphogenesis","description":"The top GO terms cluster around developmental and morphogenetic processes (hair follicle morphogenesis, bone trabecula formation, hard palate development, multicellular organism development) and hormone signaling (cellular response to estradiol stimulus, estrous cycle), with links to epithelial proliferation in wound healing. Together, they suggest a theme of tissue development and remodeling regulated by hormonal cues, with supporting metabolic and immune context.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":2},{"id":"GO:0097284","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0060054","count":2},{"id":"GO:0007275","count":2}]},{"hash":"901249181433358698","title":"Translation Machinery and Ribosome Biogenesis","description":"The dominant GO terms are translation, translational initiation, and cytosolic ribosome assembly, pointing to components of the protein synthesis machinery and ribosome biogenesis. Although a few terms touch on development and energy homeostasis, their presence is secondary to the core translation-related terms, supporting a label around ribosome biogenesis and protein synthesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:1905612","count":1},{"id":"GO:1905618","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0006413","count":1}]},{"hash":"1399785427677116165","title":"Placental development and implantation","description":"This cluster is dominated by placental-related terms: trophoblast giant cell differentiation, embryonic placenta morphogenesis, and embryo implantation, suggesting proteins involved in placental development. Additional terms on transcriptional regulation and chromatin remodeling fit with epigenetic control during early embryogenesis, reinforcing a placental/early development theme. High","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0045869","count":4},{"id":"GO:0000122","count":4},{"id":"GO:1901536","count":4},{"id":"GO:0060669","count":4}]},{"hash":"1532419206886940192","title":"Mitochondrial energy production and respiration","description":"This cluster centers on energy generation via the mitochondrial respiratory chain, including complex II assembly and proton-motive-force\u2013driven ATP synthesis, with associated catabolic pathways (acetate and succinyl-CoA) feeding into respiration. Some terms are obsolete, but the core theme is mitochondrial energy metabolism.","confidence":"High","size":16,"edges":117,"triangles":520,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0099132","count":2},{"id":"GO:0015986","count":2},{"id":"GO:0019427","count":1},{"id":"GO:0019679","count":1}]},{"hash":"2225891504022014189","title":"Neurodevelopmental signaling and axon organization","description":"This cluster\u2019s top GO terms point to developmental signaling pathways (hedgehog/Smoothened; VEGF/PDGF-related signaling) coupled with neural-specific processes such as paranode protein localization, sodium-channel clustering, and synapse organization, suggesting proteins involved in neural development and axon/synaptic connectivity. Some terms reflect broader development, but the neural connectivity themes dominate.","confidence":"High","size":16,"edges":39,"triangles":34,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":13},{"id":"GO:0010863","count":13},{"id":"GO:0038091","count":12},{"id":"GO:0007224","count":12},{"id":"GO:0045162","count":12}]},{"hash":"192579560272173423","title":"Unknown","description":"GO terms are scattered across sensory perception of sound, optic nerve morphogenesis, sprouting angiogenesis, and general signal regulation, with few annotations and no protein-protein connections, yielding no cohesive cluster theme.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0009405","count":1},{"id":"GO:0044179","count":1},{"id":"GO:1900116","count":1},{"id":"GO:1903744","count":1}]},{"hash":"2201110073677750178","title":"Unknown","description":"The top GO terms cover neural synaptic regulation, protein oligomerization, skeletal muscle development, various cardiac electrical activities, calcium release from the sarcoplasmic reticulum, skin development, bone ossification, and pancreatic apoptosis. This mix spans neural, muscular, skeletal, cardiac, and other tissue processes with no single, coherent functional theme tying all proteins together, so a focused, intuitive label isn\u2019t apparent. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0097050","count":2},{"id":"GO:1903244","count":2}]},{"hash":"856566373594588214","title":"Ion Channel\u2013Mediated Excitability and Cyclic Nucleotide Signaling","description":"The terms cluster around voltage-gated calcium channels, sodium import, and membrane depolarization, which together drive action potentials in neurons and cardiac Purkinje cells, along with responses to cyclic nucleotides (cAMP/cGMP). This points to a cohesive theme of ion-channel\u2013driven excitability modulated by cyclic nucleotide signaling. A few terms touch on related signaling pathways (pain perception, immune chemokine production) but do not dominate the set.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":3},{"id":"GO:0019228","count":2},{"id":"GO:0061577","count":2},{"id":"GO:0086047","count":2},{"id":"GO:0098719","count":2}]},{"hash":"1323613114236306067","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0030913","count":2},{"id":"GO:0039702","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0030260","count":2}]},{"hash":"1451989395321055979","title":"Cardiac Action Potential Regulation and T-tubule Localization","description":"The top GO terms overwhelmingly point to cardiac electrophysiology, including regulation of membrane depolarization during cardiac action potentials, atrial/ventricular action potentials, and T-tubule localization, suggesting these proteins are involved in cardiac electrical activity. A few terms related to apoptosis or GTPase regulation are present but secondary, so the core theme remains cardiac action potential control. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900827","count":1},{"id":"GO:0036371","count":1},{"id":"GO:0098907","count":1},{"id":"GO:0086014","count":1},{"id":"GO:0034260","count":1}]},{"hash":"1965239678522486135","title":"Embryogenesis and Morphogenesis","description":"The top GO terms cluster around early development stages (primitive streak formation) and organization of tissues and organs (cranial skeleton, ureteric bud morphogenesis, neural crest migration, pancreas, gonads, digestive tract, PNS development), with transcriptional regulation terms indicating underlying gene expression control during development. This suggests a coherent theme of embryonic development and tissue morphogenesis across multiple organ systems.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0090009","count":5},{"id":"GO:0048701","count":5},{"id":"GO:0090190","count":5},{"id":"GO:0001755","count":5}]},{"hash":"1626725880884646230","title":"Mitochondrial ATP Synthesis and Electron Transport","description":"The cluster is dominated by terms describing mitochondrial energy metabolism, including mitochondrial electron transport (NADH to ubiquinone), components of the respiratory chain, and proton motive force\u2013driven ATP synthesis, pointing to mitochondrial energy production as the overarching theme. A couple of outlier terms (flagellum assembly, angiogenesis, histidine homeostasis) may reflect annotation noise or broader cellular processes but do not override the main mitochondrial signal.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0034553","count":1},{"id":"GO:0042777","count":1},{"id":"GO:0090464","count":1}]},{"hash":"378556914009009696","title":"Eye and Nervous System Development","description":"Dominant terms cluster around visual system development (visual perception, retinal cone cell development) and peripheral nervous system myelination, suggesting a neural/retinal development theme. Supporting terms like cellular hypoxia response and ceramide biosynthesis align with lipid signaling involved in neural/retinal tissues. Some outliers (kidney development, obsolete terms) are present, but the core pattern is eye and nervous system development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042994","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0072205","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0046549","count":2}]},{"hash":"1614304698585406954","title":"Lysosomal acidification and proteolysis","description":"Genes in this cluster heavily feature vacuolar/lysosomal functions: several terms describe proton-pumping V-ATPase activity, vacuolar acidification, and proteolysis within the vacuole. Additional terms about excretion and production of TNF and IL-6 hint at secretory/immune roles that can depend on lysosomal pathways. Overall, the shared theme is lysosome/vacuole acidification driving protein turnover and related metabolism.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032760","count":3},{"id":"GO:0032755","count":2},{"id":"GO:0006797","count":1},{"id":"GO:0015991","count":1},{"id":"GO:0007588","count":1}]},{"hash":"1837225507423937166","title":"Unknown","description":"The Top Terms come from unrelated processes (sound sensing, germ cell development, clathrin-mediated endocytosis, small GTPase signaling, myelin maintenance, spindle assembly, insulin signaling) with no single dominant function tying the proteins together. The cluster also shows no edges or connectivity, and several terms are obsolete, suggesting no coherent biological theme can be inferred from this set.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0007281","count":1},{"id":"GO:0072583","count":1},{"id":"GO:0007264","count":1},{"id":"GO:0032287","count":1}]},{"hash":"2071577594371774448","title":"Muscle cell cytoskeleton and adhesion signaling","description":"Based on the top GO terms, the cluster is enriched for structural and adhesive muscle biology: sarcomere organization, skeletal muscle atrophy, cell adhesion, and remodeling of the cytoskeleton via Rho signaling. Related terms like cell polarity and axon extension also point to cytoskeletal dynamics and cell\u2013cell/matrix interactions in muscle and connected tissues. A few terms (IL-2 production, lactate production) are more peripheral, so the core theme is muscle cytoskeleton and adhesion signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900042","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0048675","count":2}]},{"hash":"1109369344804766912","title":"Unknown","description":"The top GO terms are highly diverse, spanning signaling (Rho regulation), protein quality control (ERAD), neuronal communication (glutamatergic transmission), calcium-channel activity, chromatin modification, endosome dynamics, transcription regulation, receptor recycling, mitotic chromosome behavior, and antibacterial peptide regulation. Several terms are marked obsolete, and there are no edges among the proteins, suggesting little cohesive functional theme. This makes it difficult to assign a single interpretable function to the cluster.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0035249","count":1},{"id":"GO:0060316","count":1},{"id":"GO:0034968","count":1}]},{"hash":"653094693685750163","title":"ECM-Driven Organ Development","description":"The terms point to extracellular matrix (cartilage condensation, collagen fibril organization, UDP-D-xylose metabolism for proteoglycans) and broad organogenesis processes (lung development, nephron/tubule morphogenesis, hair cell differentiation). This suggests a cluster centered on ECM remodeling coordinating developmental morphogenesis across tissues. Confidence: High","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":4},{"id":"GO:0072218","count":4},{"id":"GO:0031659","count":4},{"id":"GO:0030199","count":3},{"id":"GO:2001027","count":3}]},{"hash":"1050430563215714646","title":"Actin Dynamics in Neuronal Signaling","description":"The top GO terms point to actin cytoskeleton remodeling (regulation of Rho signaling, actin filament bundle assembly, microspike assembly, and actin cortical patch localization) and neural signaling components (positive regulation of excitatory postsynaptic potential, social and grooming behaviors). Additional terms related to cell junctions and myelin localization suggest broader membrane-associated roles, but the predominant theme centers on actin dynamics linked to neuronal signaling and behavior. The lack of edges indicates this is a functional, not a connected protein complex, grouping. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0051017","count":2},{"id":"GO:2000821","count":2},{"id":"GO:0035750","count":2},{"id":"GO:0070830","count":2}]},{"hash":"1963788251463397791","title":"Neuronal signaling and energy metabolism","description":"The cluster\u2019s top GO terms center on neural communication and signaling (adenylate cyclase\u2013activating GPCR signaling, prepulse inhibition, glutamatergic transmission, visual learning) alongside metabolic/mitochondrial processes (electron transport chain, diet-induced thermogenesis, temperature response). The presence of inflammatory and cytolytic terms also hints at a neuroimmune or stress-related context. Taken together, the proteins appear tied to neuronal signaling with an energetic/metabolic state and immune response dimension, justifying a single cohesive label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0060134","count":6},{"id":"GO:0051967","count":6},{"id":"GO:0071502","count":6}]},{"hash":"2239258136358671001","title":"Antiviral defense and mitochondrial apoptosis signaling","description":"The top GO terms point to antiviral host defense (positive regulation of defense response to virus; cellular response to exogenous dsRNA) and mitochondrial involvement in apoptosis (positive regulation of mitochondrial fission; regulation of mitochondrial outer membrane permeabilization in apoptotic signaling), along with immune cell signaling (positive regulation of T cell chemotaxis) and proliferation. This suggests a function cluster centered on coordinating antiviral responses with mitochondrial-mediated apoptosis and immune regulation, though an outlier term related to eye development is present. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002230","count":1},{"id":"GO:0043010","count":1},{"id":"GO:0090314","count":1},{"id":"GO:0007275","count":1},{"id":"GO:0032464","count":1}]},{"hash":"733717631446269679","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning plant-specific pathways (photosynthesis, cytokinin signaling) and animal processes (mitotic cell cycle, interferon response, prostate gland development) with several obsolete terms, offering no cohesive functional theme. Hence no single interpretable label.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0009736","count":1},{"id":"GO:0015979","count":1},{"id":"GO:0036494","count":1}]},{"hash":"839827771282090440","title":"Translation Initiation & Reinitiation","description":"The top GO terms are centered on translation initiation and reinitiation, including IRES-dependent initiation, formation of the preinitiation complex, and translation reinitiation, suggesting the proteins act in ribosome recruitment and initiation control. A few obsolete terms and a xenobiotic response term are present but do not define the core signature. Overall, the cluster appears to represent components involved in translation initiation and its regulation, potentially with viral IRES-related activity.","confidence":"High","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0075525","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3}]},{"hash":"2033004900784854255","title":"Embryonic organogenesis and development","description":"The top GO terms cluster around developmental and morphogenetic processes across multiple organs (midbrain, placenta, heart, embryonic eye, habenula, prostate) and include general multicellular organism development, suggesting a shared role in organogenesis rather than tissue-specific function. A single regulatory term is present but does not define the cluster.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030901","count":9},{"id":"GO:0001890","count":9},{"id":"GO:0003148","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0000122","count":9}]},{"hash":"1990871326880432924","title":"Cranial placode and neural crest nervous system development","description":"This cluster centers on nervous system formation from cranial placodes and neural crest derivatives, including otic placode development, facioacoustic and facial nerve organization, sympathetic and other ganglion development, and neural crest migration. A few terms are unrelated (e.g., molt-related processes), but the dominant theme is cranial nerve and placode-derived neural development.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":2},{"id":"GO:0045444","count":2},{"id":"GO:1903375","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0021612","count":1}]},{"hash":"1654097946717927563","title":"Embryonic morphogenesis and epithelial polarity","description":"The top GO terms cluster around developmental processes, especially embryonic body morphogenesis, regulation of gastrulation, and epithelial polarity (e.g., polarity of follicular epithelium, lung morphogenesis). While there are some transport and neural-related terms, the strongest shared theme is morphogenesis and epithelial organization during development, justifying this label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050766","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0021682","count":1},{"id":"GO:0010470","count":1},{"id":"GO:1903798","count":1}]},{"hash":"2218408233561364734","title":"Developmental morphogenesis and cell signaling","description":"This cluster repeatedly hits morphogenesis-related terms (palatal shelf, pericardium development) alongside adhesion and signaling processes (calcium-independent cell-matrix adhesion, receptor clustering, nitric oxide and glutamatergic signaling). The mix suggests a theme around developmental tissue shaping coupled with cell communication and adhesion, with a few outliers (e.g., PHB biosynthesis) not aligning to the main theme. ","confidence":"Medium","size":15,"edges":32,"triangles":20,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0007161","count":6},{"id":"GO:0051968","count":6},{"id":"GO:1990134","count":6},{"id":"GO:0007568","count":6}]},{"hash":"1519023290825258832","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0000472","count":3}]},{"hash":"176038442789886508","title":"Post-transcriptional RNA processing and translation initiation","description":"The terms cluster around spliceosome-mediated mRNA splicing and regulation of mRNA stability, together with assembly of the eIF4F complex and IRES-dependent translation initiation. This pattern points to a functional group focused on post-transcriptional RNA processing and the initiation of translation, i.e., regulation of gene expression after transcription via splicing and translation machinery.","confidence":"Medium","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0006378","count":7},{"id":"GO:0045292","count":7},{"id":"GO:0010610","count":7}]},{"hash":"1549450157194807574","title":"Ubiquitination and Endocytic Regulation","description":"The top GO terms are dominated by ubiquitination-related processes (protein ubiquitination, autoubiquitination, K48- and K63-linked ubiquitination, and negative regulation of ubiquitination) as well as ubiquitin-dependent endocytosis and endocytic recycling. This points to a cluster of proteins centered on ubiquitin signaling that governs endocytosis and trafficking. While a few terms touch on broader signaling and development (GTPase regulation, apoptotic process, convergent extension), the prevailing theme is ubiquitin-mediated regulation of endocytic pathways.","confidence":"High","size":15,"edges":48,"triangles":64,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0070086","count":2},{"id":"GO:0006915","count":2},{"id":"GO:1990126","count":2}]},{"hash":"1091276961695939962","title":"Forebrain and Cortex Interneuron Development","description":"This cluster is strongly enriched for brain development terms, especially cerebral cortex GABAergic interneuron differentiation and fate commitment, along with forebrain patterning and midbrain development, suggesting a coherent theme of neural development and interneuron specification.","confidence":"High","size":15,"edges":35,"triangles":27,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":12},{"id":"GO:0021759","count":12},{"id":"GO:0090009","count":11},{"id":"GO:0021892","count":11},{"id":"GO:0021798","count":11}]},{"hash":"272456843943376965","title":"GPCR-cAMP Signaling and Cytokine Regulation","description":"This cluster is rich in GO terms tied to GPCR signaling and cAMP pathways (activation/inhibition of adenylate cyclase, dopamine receptor signaling) and cytokine production (IL-6, IL-1\u03b2). While a few terms like saliva secretion and viral release are less related, the dominant pattern points to adrenergic GPCR-driven signaling and inflammatory regulation.","confidence":"Medium","size":15,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019076","count":4},{"id":"GO:0032675","count":3},{"id":"GO:0046541","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0071883","count":3}]},{"hash":"772365983887439979","title":"Nuclear import/export and pore assembly","description":"This cluster is dominated by GO terms describing nucleocytoplasmic transport: mRNA export from the nucleus, nuclear pore complex assembly, and import of NLS-bearing and ribosomal proteins into the nucleus, suggesting a core function in nucleocytoplasmic trafficking. Some outliers (lysosomal targeting, synaptic vesicle organization) exist but do not define the main theme. Confidence is high that this label captures the cluster\u2019s representative function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0051292","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0060188","count":2}]},{"hash":"1652552121922327505","title":"Unknown","description":"The GO terms are broad and diverse (immune signaling, heart development, angiogenesis, hypoxia response, metabolism, chromatin remodeling, protein ubiquitination) with no dominant shared function across the 15 proteins. As a result, there is no clear single theme to label the cluster.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0071456","count":2}]},{"hash":"689295964292508307","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for translation, ribosome biogenesis, rRNA maturation, and small subunit assembly, indicating proteins involved in ribosome production and protein synthesis. The additional terms related to stress responses and ubiquitin-mediated regulation likely reflect broader cellular context but do not change the core ribosome-focused theme.","confidence":"High","size":15,"edges":65,"triangles":137,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000462","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000028","count":2},{"id":"GO:0071157","count":1}]},{"hash":"589815674065533595","title":"Neural development and synaptic signaling","description":"This cluster centers on neural development and synaptic activity: axonogenesis, long-term synaptic potentiation, and excitatory postsynaptic potentials point to neuronal signaling, while visual perception suggests retina/vision-related functions. The mixed terms like heart development and abscisic acid signaling may reflect multifunctional proteins or cross-species annotations, but the dominant terms tie to neural growth and synaptic function.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0006469","count":6},{"id":"GO:0007409","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0060079","count":5}]},{"hash":"851204704858844556","title":"GPCR-cAMP Signaling in Growth Hormone Secretion and Neurodevelopment","description":"The GO terms cluster around GPCR pathways that activate adenylate cyclase and raise cAMP, with strong signals for growth hormone secretion and neural processes (neuron migration, synapse maintenance, motor learning). This points to a cohesive theme of GPCR-cAMP signaling coordinating endocrine and neural development functions.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072520","count":4},{"id":"GO:0007200","count":4},{"id":"GO:0061743","count":3},{"id":"GO:0060124","count":3},{"id":"GO:0048105","count":3}]},{"hash":"825746529385724744","title":"Neuroendocrine Signaling","description":"The cluster includes GO terms tied to neural activity and learning (excitatory postsynaptic potential; visual learning; response to cocaine) alongside endocrine pathways (insulin receptor signaling; thyroid gland development). The presence of growth regulation and osmotic stress modulation suggests the proteins participate in broader signaling networks that coordinate neural and endocrine development and responses across tissues. ","confidence":"Medium","size":15,"edges":95,"triangles":362,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007118","count":15},{"id":"GO:0008542","count":14},{"id":"GO:0047484","count":14},{"id":"GO:0008285","count":14},{"id":"GO:0060079","count":14}]},{"hash":"750011865837326756","title":"Cytoskeletal dynamics and trafficking signaling","description":"The terms cluster around cytoskeletal dynamics (actin remodeling, Rho signaling) and membrane trafficking (COPII budding, phosphatidylinositol metabolism), with developmental and signaling contexts in neurons and other cells (dendritic spine and hippocampus development, thrombin signaling, acrosome reaction). This points to a unifying theme of cytoskeleton-driven signaling and trafficking.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060304","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0090307","count":2}]},{"hash":"911402314357036379","title":"Ubiquitin/SUMO Proteostasis and ERAD","description":"The cluster is enriched with GO terms tied to post-translational modification and protein quality control, notably protein sumoylation, ubiquitin-dependent ERAD, and deubiquitination, plus tail-anchored protein insertion into the ER membrane and autophagy-related regulation. This points to a cohesive theme of protein turnover and ER-associated quality control, with additional signals of broader cellular maintenance roles.","confidence":"High","size":15,"edges":98,"triangles":368,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":8},{"id":"GO:0030433","count":5},{"id":"GO:0016579","count":5},{"id":"GO:0071816","count":4},{"id":"GO:0030474","count":4}]},{"hash":"582145352212045622","title":"Neural signaling and Schwann cell development","description":"The top GO terms point to neural activity (excitatory postsynaptic potential, response to cocaine) and Schwann cell development, with related signaling and extracellular matrix processes (integrin signaling, hyaluronan metabolism). While there are cell cycle/dna replication terms suggesting proliferation, the dominant theme appears to be neural signaling alongside Schwann cell development and nerve-associated ECM interactions. Confidence: Medium","confidence":"","size":15,"edges":36,"triangles":31,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":12},{"id":"GO:0042220","count":12},{"id":"GO:0000082","count":12},{"id":"GO:0051321","count":12},{"id":"GO:0014044","count":12}]},{"hash":"1503204876784645025","title":"RNA Processing and Gene Expression Regulation","description":"This cluster centers on transcription initiation/regulation, splicing, and RNA processing, plus translational regulation, indicating a cohesive theme around RNA processing and control of gene expression at transcriptional and translational levels (with a few peripheral terms).","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":2},{"id":"GO:0000388","count":1},{"id":"GO:0010226","count":1},{"id":"GO:0001113","count":1},{"id":"GO:0016032","count":1}]},{"hash":"1436606963721875284","title":"Neural Development and Synaptic Signaling","description":"The cluster is dominated by neural-related GO terms: excitatory postsynaptic potential, visual perception, axonogenesis, and long-term synaptic potentiation, indicating roles in neuronal development and synaptic function. Other terms like mitotic cell cycle, angiogenesis, and myoblast fusion suggest broader developmental processes or pleiotropic roles, but the core signal points to neural development and synaptic signaling.","confidence":"Medium","size":15,"edges":14,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":13},{"id":"GO:0010800","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0009738","count":13},{"id":"GO:0000278","count":13}]},{"hash":"367072729896762313","title":"Golgi-ER trafficking and ciliogenesis","description":"The proteins are enriched for vesicle transport between the Golgi and ER, Golgi localization, and microtubule-related processes (including cilium assembly). While some development-related terms appear, the core signals point to intracellular trafficking supporting ciliogenesis. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0043473","count":2}]},{"hash":"298255043885738061","title":"Mitochondrial import and neuronal signaling","description":"The top GO terms are strongly anchored to mitochondrial physiology: protein import into the mitochondrial matrix, cristae formation, calcium import into the mitochondrion, and related transport processes. These core mitochondrial functions are complemented by terms tied to neuronal activity (synaptic transmission, learning, fear response), suggesting a cluster of mitochondrial proteins with relevance to neuronal signaling and calcium handling. The outlier terms seem less central, so the dominant theme is mitochondria with a neuronal context.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0042407","count":2},{"id":"GO:0006820","count":2},{"id":"GO:0036444","count":2},{"id":"GO:0030855","count":2}]},{"hash":"1948194372181471765","title":"Neuronal GPCR Signaling and Immune Modulation","description":"Based on the top GO terms, this cluster appears enriched for GPCR-mediated signaling in neural and neuroendocrine contexts: activation or inhibition of adenylate cyclase, MAPK-activating adrenergic receptor signaling, and dopamine receptor signaling. Additional terms point to autonomic functions like saliva secretion and circadian regulation that are tightly linked to CNS signaling. The inclusion of immune-related terms (regulation of IL-6 and IL-1\u03b2 production) suggests a concurrent modulation of inflammatory cytokine pathways, common in neuroimmune signaling. Together, these terms suggest a cohesive theme of neuronal GPCR signaling coordinating neuroendocrine and immune responses.","confidence":"Medium","size":15,"edges":16,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042752","count":2},{"id":"GO:0032675","count":1},{"id":"GO:0046541","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0071883","count":1}]},{"hash":"952914671000323154","title":"Ribosome biogenesis and tRNA modification","description":"This cluster is enriched for terms related to ribosome assembly and function (ribosome biogenesis, cytoplasmic translation, ribosomal export) as well as RNA modification (tRNA methylation/modification), suggesting proteins involved in ribosome production and translation; a few other terms (cell cycle, biotin biosynthesis) appear as minor associations.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030488","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0051301","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0042254","count":1}]},{"hash":"2131547627766463797","title":"Mitochondrial and Cytoplasmic Translation Machinery","description":"The cluster is strongly enriched for translation-related GO terms, including mitochondrial translation, cytoplasmic translation, translation itself, initiation, and selenocysteine incorporation, plus regulation of translation in response to amino acid starvation. A couple of terms (glial cell proliferation, cell septum assembly) are less directly connected, likely reflecting ancillary processes or annotation noise, but the dominant signal points to protein synthesis machinery and its regulation.","confidence":"High","size":15,"edges":14,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0014009","count":2},{"id":"GO:0090529","count":2}]},{"hash":"512351715868635883","title":"Cell stress response and DNA repair","description":"This cluster centers on apoptosis, DNA repair (base-excision repair, DNA recombination), and redox homeostasis, all of which are core components of the cellular response to stress and genome maintenance. The presence of PI dephosphorylation hints at signaling pathways that can regulate these stress responses, while other terms like corneocyte development and mRNA stability regulation may be related peripherally to differentiation and gene expression under stress. Overall, the common theme appears to be cellular damage response and survival mechanisms.","confidence":"Medium","size":15,"edges":27,"triangles":10,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046856","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0045454","count":8},{"id":"GO:0014912","count":8},{"id":"GO:0003335","count":8}]},{"hash":"1690728472229420378","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around organism growth and the formation and differentiation of various tissues (hindlimb, fat, retina, trachea cartilage, lymphatic endothelium) as well as neuron differentiation timing, indicating a common theme of developmental regulation rather than a single pathway.","confidence":"High","size":15,"edges":36,"triangles":15,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":4},{"id":"GO:0043124","count":4},{"id":"GO:0035116","count":4},{"id":"GO:0045444","count":4},{"id":"GO:0003406","count":3}]},{"hash":"1331352661972932031","title":"Neuronal signaling and learning","description":"The top GO terms cluster around neural function: excitatory postsynaptic potentials, visual learning, and responses to cocaine, pointing to a brain/neuronal signaling theme. Some other terms (DNA replication, thyroid development, osmotic stress response) appear more general or pleiotropic, but the dominant pattern is neural signaling and learning.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":13},{"id":"GO:0008542","count":10},{"id":"GO:0047484","count":10},{"id":"GO:0008285","count":10},{"id":"GO:0060079","count":10}]},{"hash":"1881549507826245586","title":"Mitotic and Meiotic Cell Cycle Checkpoints","description":"The proteins are enriched for GO terms tied to mitosis and meiotic processes, including mitotic cell cycle, spindle assembly checkpoint signaling, meiotic recombination checkpoint signaling, and regulation of homologous chromosome segregation, with microsporogenesis reinforcing the meiosis-related theme. While a couple of terms touch on transcription regulation, the dominant pattern points to regulators of chromosome segregation and checkpoint control during cell division, covering both mitotic and meiotic contexts.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0042177","count":1},{"id":"GO:0010944","count":1},{"id":"GO:2000678","count":1},{"id":"GO:0051598","count":1}]},{"hash":"1183269872868142763","title":"Unknown","description":"Top GO terms span ubiquitination, chromatin assembly and histone modification, autophagy regulation, intracellular transport of viral material, visual perception, dopaminergic synaptic transmission, estradiol secretion, and septin ring organization. This broad mix lacks a single cohesive functional theme, so a precise, representative name cannot be assigned with confidence.","confidence":"","size":15,"edges":12,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0032226","count":2},{"id":"GO:0006334","count":1}]},{"hash":"578528632861396968","title":"Cardiac and neural excitability via ion channels","description":"The top GO terms cluster around ion channel\u2013driven electrical activity: cardiac muscle action potentials, repolarization, calcium and potassium transport, heart rate regulation, and neuronal action potentials. Some terms about temperature and development are less central but may reflect broader regulatory contexts. Overall, this cluster seems to capture proteins involved in excitable tissue function and conduction.","confidence":"High","size":15,"edges":13,"triangles":3,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071502","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0098914","count":7},{"id":"GO:0086091","count":7}]},{"hash":"2079712852630757482","title":"Developmental signaling and tissue remodeling","description":"This cluster's terms revolve around development and tissue remodeling across organs (glom\u00aderulus, nipple, bone, lung, ovary), indicating a broad developmental role. Additional signaling-related terms (adenylate cyclase activation, IP3 biosynthesis) and processes like acetylcholine metabolism and inflammatory response suggest these proteins participate in general signaling and remodeling across tissues rather than a single, cohesive pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":7},{"id":"GO:0007190","count":5},{"id":"GO:0072224","count":5},{"id":"GO:0060658","count":5},{"id":"GO:0046849","count":5}]},{"hash":"764723007501651372","title":"ER-Golgi vesicle trafficking","description":"The top GO terms are all about endoplasmic reticulum to Golgi transport, ER membrane fusion, and Golgi/ER organization, indicating the proteins mainly participate in vesicle trafficking between ER and Golgi and related membrane organization.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016320","count":1},{"id":"GO:0006890","count":1},{"id":"GO:1902117","count":1},{"id":"GO:1903358","count":1},{"id":"GO:0090158","count":1}]},{"hash":"1903244775525488547","title":"Sodium signaling in sensory neurons","description":"The proteins cluster around sodium ion transport/homeostasis and multiple sensory modalities (pain, salty taste, mechanosensation), along with regulation of neurotransmitter release and synaptic activity, indicating a common theme of sodium-driven neuronal signaling underlying sensory perception.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0050965","count":1},{"id":"GO:0046929","count":1},{"id":"GO:0060025","count":1},{"id":"GO:1905792","count":1}]},{"hash":"2065538779847516668","title":"Neural development and synapse formation","description":"The terms cluster around nervous system/brain development and synaptic functions (glutamatergic transmission, synapse assembly), with regulatory GTPase/Rho signaling that modulates cytoskeletal dynamics critical for neurite outgrowth and synapse formation. Some outliers (ergosterol regulation, obsolete insulin signaling) are less central, but do not override the neural theme.","confidence":"Medium","size":15,"edges":70,"triangles":143,"max_degree":12,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0043087","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0035249","count":4},{"id":"GO:0038028","count":4}]},{"hash":"984335703226499676","title":"Immune and Coagulation Regulation","description":"This cluster is dominated by immune-related GO terms (complement activation via the lectin pathway; adaptive immune response) and hemostasis/coagulation cues (plasminogen activation; negative regulation of platelet aggregation). While metabolic and bone-related terms appear, the strongest shared theme centers on immune signaling intertwined with coagulation and fibrinolysis, justifying a label focused on immune-coagulation regulation.","confidence":"High","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0030210","count":4},{"id":"GO:0031639","count":4},{"id":"GO:0051005","count":4},{"id":"GO:0070328","count":4}]},{"hash":"2129964338858793363","title":"Unknown","description":"The top GO terms are highly diverse, spanning extracellular matrix/heparin proteoglycan synthesis, plasminogen activation, lipid metabolism, adipokine/leptin response, muscle satellite cell proliferation, adaptive immune response, Wnt signaling in osteoblasts, platelet aggregation, and prostate development. With no edges or shared functional theme, there isn\u2019t a single cohesive function that defines this cluster. Therefore the appropriate label is Unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030210","count":1},{"id":"GO:0031639","count":1},{"id":"GO:0051005","count":1},{"id":"GO:0070328","count":1},{"id":"GO:0044320","count":1}]},{"hash":"1167587797410177769","title":"Sugar Catabolism Across Multiple Sugars","description":"Top GO terms cluster around diverse sugar catabolic processes (arabinose, rhamnose, fucose, lyxose) and ascorbate catabolism, suggesting a shared role in carbohydrate breakdown. A couple of membrane-related terms appear but are less representative. Overall, the dominant theme is varied sugar metabolism, justifying this label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006509","count":2},{"id":"GO:0032456","count":2},{"id":"GO:0019854","count":1},{"id":"GO:0019569","count":1},{"id":"GO:0019571","count":1}]},{"hash":"1009574479274554049","title":"Hematopoiesis and Immune Signaling","description":"The top GO terms point to blood cell development and immune-related signaling (kit signaling pathway, megakaryocyte development, angiogenesis, T cell receptor signaling regulation, dendritic cell processes, synapse organization). This suggests a theme around hematopoietic/immune system regulation and signaling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000670","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0038109","count":2}]},{"hash":"1635217942296880485","title":"Unknown","description":"The top GO terms span disparate biological areas (cell proliferation, behavioral responses, insulin regulation, bacterial cell wall and peptidoglycan catabolism, glomerular filtration, viral release, endothelial migration, proteolysis, and collagen remodeling) with no clear shared pathway or function. The cluster has no edges or structure, suggesting either heterogeneous annotations or lack of a cohesive theme. Therefore, there is no confident, representative label.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0001662","count":2},{"id":"GO:0050796","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0003093","count":2}]},{"hash":"573450117013900170","title":"Neural learning and sensory behavior","description":"This cluster's GO terms converge on learning across multiple senses (visual, olfactory, taste) and behavior in response to stimuli, plus neural signaling components (excitatory postsynaptic potentials and potassium transport) and lateral-line sensory system development, suggesting a cohesive theme of experience-dependent neural processing.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0048899","count":1},{"id":"GO:0048169","count":1},{"id":"GO:0001661","count":1}]},{"hash":"64883946250973747","title":"Embryonic development and differentiation","description":"These proteins show GO terms centered on development and differentiation\u2014multicellular organism development, inner cell mass proliferation, and retina vasculature development point to embryogenesis and organ formation, while cell differentiation and nuclear maintenance reflect fate regulation and gene expression control; a few terms about tissue junctions suggest structural organization during development. Overall, the cluster points to developmental programs rather than a single pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":1},{"id":"GO:0030154","count":1},{"id":"GO:0045598","count":1},{"id":"GO:0051457","count":1},{"id":"GO:0007275","count":1}]},{"hash":"1586868489951319191","title":"Translation and Aminoacyl-tRNA Charging","description":"The top terms cluster around protein synthesis: translation in general, regulation of translational fidelity, and several aminoacyl-tRNA synthetases (leucyl-, valyl-, cysteinyl-, methionyl-, isoleucyl-tRNA synthetases). This points to a core function in tRNA charging and translation machinery. A couple of other terms (mycothiol biosynthesis and positive regulation of apoptosis/oxidation) appear as minor outliers and are not central to this cluster.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900119","count":2},{"id":"GO:0006450","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0006429","count":1},{"id":"GO:0006438","count":1}]},{"hash":"1677359692833604039","title":"Immune and vascular development with placental differentiation","description":"The GO terms cluster around immune activity (adaptive immune response, complement activation) and coagulation/fibrinolysis (plasminogen activation, fibrinolysis), along with broad developmental processes including angiogenesis, endocardial EMT, trophoblast differentiation, and other organ development. This suggests a theme of immune-coagulation interplay within vascular and placental development, though individual proteins may participate in multiple contexts.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031639","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0042730","count":3}]},{"hash":"430733134382819588","title":"Unknown","description":"The top GO terms are a mix of general transcription/ RNA polymerase assembly and unrelated processes (e.g., photoreceptor axon guidance, apoptotic cell engulfment), with no clear unifying biological theme linking all proteins in this cluster. Therefore, a coherent, specific label cannot be assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010467","count":2},{"id":"GO:0007021","count":1},{"id":"GO:0031137","count":1},{"id":"GO:0032968","count":1},{"id":"GO:1990113","count":1}]},{"hash":"821916735415864716","title":"Cytokine-regulated immune defense","description":"Based on the GO terms, the proteins are mainly linked to immune signaling and inflammatory responses, especially positive regulation of multiple cytokines (IL-6, IL-5, IL-13, IL-23), defense against viruses and fungi, and granulocyte chemotaxis, with an additional note on B cell apoptosis, all indicating an immune-defense-focused cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":2},{"id":"GO:2000778","count":1},{"id":"GO:2000664","count":1},{"id":"GO:0002230","count":1},{"id":"GO:0050832","count":1}]},{"hash":"753528959322086678","title":"Photoreceptor opsin signaling and GPCR trafficking","description":"This cluster is dominated by GO terms tied to vision and GPCR dynamics: visual perception, opsin-mediated signaling, GPCR internalization, and clathrin-dependent endocytosis, suggesting phototransduction-related receptor cycling and membrane trafficking in photoreceptor cells. Additional terms hint at cytoskeletal rearrangements supporting endocytosis. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0043149","count":2},{"id":"GO:0090327","count":2},{"id":"GO:0002031","count":2},{"id":"GO:0022400","count":2}]},{"hash":"1747973453503509271","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036297","count":1},{"id":"GO:0033683","count":1},{"id":"GO:0061158","count":1},{"id":"GO:0031664","count":1},{"id":"GO:2000637","count":1}]},{"hash":"699375303213489045","title":"Muscle development and membrane dynamics","description":"The top GO terms cluster around muscle-related processes and membrane dynamics, including myoblast fusion, muscle organ morphogenesis, T-tubule organization, and plasma membrane repair, with synaptic vesicle exocytosis also fitting into membrane trafficking contexts often shared with muscle cells. Some terms (nuclear pore assembly, ER-dependent peroxisome organization, eggshell pattern formation) are less directly connected but may reflect broader cellular architecture and development roles. Overall, the cluster appears focused on muscle differentiation and membrane maintenance.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016079","count":2},{"id":"GO:0051292","count":2},{"id":"GO:0032581","count":2},{"id":"GO:0001778","count":1},{"id":"GO:0033292","count":1}]},{"hash":"1456805917858070400","title":"Nucleic acid maintenance and ribosome biogenesis","description":"The cluster centers on DNA damage response and repair (SOS, nucleotide-excision repair) alongside RNA processing and ribosome assembly (mRNA splicing, rRNA maturation, ribosomal subunit biogenesis), suggesting a shared theme of nucleic acid maintenance and ribosome biogenesis; a single outlier term like embryonic development may reflect annotation noise.","confidence":"Medium","size":14,"edges":21,"triangles":3,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009432","count":5},{"id":"GO:0018144","count":4},{"id":"GO:0000184","count":4},{"id":"GO:0006289","count":4},{"id":"GO:0006268","count":4}]},{"hash":"2028223740966256428","title":"Planar Polarity and Neural Guidance","description":"The cluster centers on cadherin-mediated cell-cell adhesion and establishment of planar polarity (PCP), with associated apical localization and body-axis orientation terms, plus serotonergic/dopaminergic axon guidance and synapse-related assembly. This combination points to a cohesive theme of planar polarity processes linked to neural connectivity and epithelial organization.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044331","count":3},{"id":"GO:0007156","count":2},{"id":"GO:0090251","count":2},{"id":"GO:0045176","count":2},{"id":"GO:0036515","count":2}]},{"hash":"2136669098624015024","title":"RNA processing and splicing regulation","description":"The cluster\u2019s top GO terms cluster around post-transcriptional RNA handling: regulation of mRNA stability in stress, mRNA splicing via the spliceosome, regulatory ncRNA-mediated silencing, and positive regulation of splicing, plus assembly of translation initiation factors. Although a few terms are obsolete, the dominant theme is RNA maturation and processing, not a single enzymatic activity, supporting a cohesive RNA-centric function for the group.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0006378","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5}]},{"hash":"839924405736406159","title":"Nuclear transport and ribosome biogenesis","description":"The terms point strongly to nucleocytoplasmic transport and ribosome assembly processes: ribosome biogenesis and large subunit export from the nucleus, mRNA export, nuclear pore complex assembly, and Ran-mediated signaling. Additional terms like tRNA transport and astral microtubule organization suggest coordination with RNA processing and cell division. Together these indicate a cohesive cluster of nuclear transport/ribosome biogenesis functions.","confidence":"High","size":14,"edges":81,"triangles":271,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0035948","count":2},{"id":"GO:0006608","count":2}]},{"hash":"1190149116351057196","title":"Cerebellar neurodevelopment and cell cycle control","description":"This cluster\u2019s top GO terms cluster around cerebellar development (Bergmann glial cell differentiation, cerebellar cortex formation) and neural regeneration, with supporting signals related to cell cycle regulation (DNA replication, negative regulation of CDK activity, negative regulation of cell proliferation) and other signaling pathways. The mix suggests a theme of cerebellar neural development coupled with proliferation control, though broader signaling terms are also present. Overall, a coherent cerebellar development and cell-cycle focus best fits the set.","confidence":"Medium","size":14,"edges":8,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":10},{"id":"GO:0045736","count":10},{"id":"GO:0008285","count":10},{"id":"GO:0008286","count":10},{"id":"GO:0060020","count":10}]},{"hash":"1634176512989298058","title":"Neuronal synapse signaling and neurite morphogenesis","description":"The top GO terms point to excitatory synaptic activity, dendrite/axon development, and associated signaling pathways (ephrin signaling, ERK/JNK cascades, MAPKK activity) as well as hippocampus development, indicating a coherent role in synaptic signaling and neurite outgrowth in neurons.","confidence":"High","size":14,"edges":36,"triangles":32,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":13},{"id":"GO:0051893","count":13},{"id":"GO:0043552","count":13},{"id":"GO:0046330","count":13},{"id":"GO:0000186","count":13}]},{"hash":"389186785930804499","title":"Neuronal signaling and cytoskeletal remodeling","description":"The Top Terms cluster converges on neuronal signal transduction and cytoskeletal dynamics: regulation of Rho signaling (cytoskeleton), glutamatergic synaptic transmission, ephrin signaling, and ERK cascade regulation\u2014all central to synaptic function and plasticity. Negative regulation of dendritic spine development and terms related to cytoskeletal/ECM remodeling (sarcomere organization, hyaluronan metabolism) support a theme of synaptic structure modulation and signaling. Overall, these proteins likely participate in neuronal communication and cytoskeletal rearrangements at synapses.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0035249","count":2},{"id":"GO:0031666","count":2},{"id":"GO:0061000","count":2},{"id":"GO:0043552","count":2}]},{"hash":"2265634433303758674","title":"Nuclear DNA Repair and Transcription","description":"The cluster shows enrichment for DNA damage response via homologous recombination, mRNA splicing, and DNA-templated transcription, suggesting a core theme of nuclear genome maintenance and gene expression. Some terms point to signaling and cytoskeletal processes (GTPase activity regulation, Rho signaling, cilium assembly), but the strongest shared functions appear tied to nuclear DNA processing and transcriptional regulation, justifying the label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000724","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0071560","count":2}]},{"hash":"1350617183271095753","title":"Cranial nerve and ear development","description":"The top GO terms cluster around facioacoustic ganglion and otic placode/ear development, facial nerve organization, and neural crest\u2013driven migration, with related axon domain localization terms, suggesting a shared role in cranial nerve and ear organogenesis and early neuronal connectivity.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903375","count":2},{"id":"GO:0036486","count":2},{"id":"GO:0021612","count":2},{"id":"GO:1905040","count":2},{"id":"GO:0030913","count":2}]},{"hash":"774692478459452545","title":"Neuronal development and signaling","description":"Most informative terms center on neural development and function, notably dendrite morphogenesis and sensory perception of pain, along with broader multicellular development. Additional signals relate to transcriptional regulation, ion transport, glucose response, protein export from the nucleus, and centrosome cycling, which together can accompany neural differentiation and neuron signaling. The presence of an obsolete term (GO:0043552) doesn't affect the overall interpretation. Taken together, this cluster likely represents neuronal development and signaling programs rather than a single enzyme or pathway.","confidence":"Medium","size":14,"edges":7,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043552","count":11},{"id":"GO:0048813","count":11},{"id":"GO:0007275","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0006351","count":11}]},{"hash":"175640780585722640","title":"Adaptive immune and angiogenic signaling","description":"This cluster centers on adaptive immune response and angiogenesis, with positive regulation of endothelial cell migration and ERK1/ERK2 pathway modulation, suggesting proteins involved in immune signaling that also influence vascular development via ERK signaling. Some terms appear unrelated (fungal cell wall synthesis, chaperone-assisted protein folding), possibly reflecting annotation noise or multifunctional proteins, but the core theme remains immune-vascular signaling mediated by ERK pathways.","confidence":"Medium","size":14,"edges":8,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0043536","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0000742","count":2}]},{"hash":"1228234617771381249","title":"Multi-tissue embryonic development and differentiation","description":"The listed GO terms point to a range of development-related processes across tissues (amacrine cell differentiation, floor plate and somitogenesis, lung vasculature, soft palate, mammary alveolus) and general transcriptional activity, suggesting the cluster reflects broad embryonic development and cellular differentiation rather than a single pathway or tissue.","confidence":"Medium","size":14,"edges":87,"triangles":318,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035881","count":6},{"id":"GO:0060426","count":6},{"id":"GO:0033504","count":6},{"id":"GO:0006366","count":6},{"id":"GO:0061030","count":6}]},{"hash":"363688511953926081","title":"Dopaminergic Visual Processing and Cocaine Response","description":"The terms prevalent in this cluster\u2014visual perception/learning, dopaminergic synaptic transmission, and behavioral response to cocaine\u2014plus related signaling (ERK cascade) and membrane potential regulation, collectively point to neural processing of visual information intertwined with reward-related dopaminergic signaling and excitability control.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0048148","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0060134","count":2}]},{"hash":"1860408540132377051","title":"Neuronal synaptic signaling and plasticity","description":"The cluster is dominated by terms tied to neurons and synapses: glutamatergic synaptic transmission, dendritic spine morphogenesis, calcium ion transport, and memory (short-term and long-term). The presence of calcium-dependent signaling (calcineurin-NFAT) and DNA-templated transcription suggests activity-related transcriptional regulation at synapses. Together, these point to proteins involved in synaptic function and plasticity, with auxiliary links to neuronal signaling regulation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1014052616989353018","title":"Circadian and Hormone Regulation of Development","description":"The cluster\u2019s top GO terms emphasize circadian regulation of gene expression and hormonal signaling (estradiol response, androgen receptor pathway), alongside diverse developmental processes in neural and cardiac tissues (retina, cortex interneuron differentiation, heart tube formation). This suggests a theme of transcriptional regulation during development that is modulated by circadian and hormonal inputs, with broader environmental responsiveness reflected by xenobiotic stimulus reaction.","confidence":"Medium","size":14,"edges":77,"triangles":234,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032922","count":9},{"id":"GO:0045668","count":8},{"id":"GO:0060766","count":8},{"id":"GO:0043433","count":8},{"id":"GO:0009410","count":8}]},{"hash":"351393429276790812","title":"Multitissue Developmental Differentiation","description":"The top GO terms span bone ossification, cardiac electrophysiology, hair patterning, vascular maturation, kidney nephron differentiation, B cell differentiation, synapse assembly, and sensory perception, indicating a broad developmental/differentiation theme across multiple tissues rather than a single pathway.","confidence":"Medium","size":14,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0098911","count":2},{"id":"GO:0045317","count":1},{"id":"GO:0048105","count":1},{"id":"GO:0001955","count":1}]},{"hash":"2225849675007842309","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0046677","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0034474","count":3},{"id":"GO:0044387","count":3}]},{"hash":"2204899588905973360","title":"RNA Splicing and Translation Initiation","description":"The top GO terms cluster around mRNA splicing via the spliceosome and multiple stages of translation initiation (including IRES-dependent viral initiation, reinitiation, preinitiation complex formation, and eIF4F complex assembly). This points to a cohesive module involved in RNA processing and the assembly/regulation of translation initiation, rather than a single metabolic pathway.","confidence":"High","size":14,"edges":8,"triangles":1,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0075522","count":6},{"id":"GO:0006446","count":6},{"id":"GO:0075525","count":6},{"id":"GO:0002188","count":6}]},{"hash":"306830483655913083","title":"Drosophila imaginal disc morphogenesis and apoptosis","description":"The top GO terms point to imaginal disc development (eye-antennal and leg discs) and other morphogenesis processes (gonad and organ morphogenesis) along with apoptotic and hormone-mediated apoptotic signaling. A translation term suggests core cellular machinery, and a couple of behavioral terms may reflect downstream phenotypes. Overall, the cluster resembles Drosophila developmental morphogenesis with cell death regulation.","confidence":"Medium","size":14,"edges":14,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070266","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0035297","count":1},{"id":"GO:0061040","count":1}]},{"hash":"1464056008659725286","title":"Unknown","description":"The top terms are broadly scattered across RNA metabolism, transcription regulation, development, and metabolism with no single cohesive theme linking the proteins. Edges are absent, so there\u2019s no network-based rationale to anchor a more specific label.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090660","count":1},{"id":"GO:0072114","count":1},{"id":"GO:0048858","count":1},{"id":"GO:0046709","count":1},{"id":"GO:0045337","count":1}]},{"hash":"2228117116946220853","title":"Vertebrate brain and eye morphogenesis","description":"GO terms in this cluster predominantly point to vertebrate embryonic neural and ocular development (midbrain development, brain segmentation, rhombomere development, camera-type eye development, embryonic eye morphogenesis), with additional signals of transcriptional regulation during development. This pattern suggests a cohesive role in early neural and eye patterning and morphogenesis, making the label representative. ","confidence":"High","size":14,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0030901","count":8},{"id":"GO:0090009","count":5},{"id":"GO:0048935","count":5},{"id":"GO:0043010","count":5}]},{"hash":"2006191844271606890","title":"Membrane transport of lipids, vitamins, and amino acids","description":"The cluster shows enrichment in lipoprotein transport, cholesterol efflux, cholesterol homeostasis, and vitamin and amino acid transport, indicating a shared function in transmembrane transport of small molecules. Some plant- or pigment-related terms appear less central and may reflect annotation noise or context-specific roles.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042953","count":2},{"id":"GO:0033344","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0071366","count":1},{"id":"GO:0031288","count":1}]},{"hash":"1725667107628838679","title":"Muscle mechanotransduction signaling","description":"The top GO terms cluster around mechanical responsiveness and signaling in muscle tissue: cellular response to mechanical stimulus, regulation of muscle contraction (cardiac and skeletal), and cardiac development, together with related signaling pathways such as NF-kappaB and SMAD. This suggests proteins in the cluster participate in mechanosensitive signaling processes that govern muscle function and survival, with ancillary connections to broader signaling (angiotensin/Ca2+-PLC) that can operate in muscle and cardiovascular contexts. Although a few terms are older/obsolete, the dominant theme is muscle mechanotransduction and signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007182","count":3},{"id":"GO:0007026","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0051092","count":3}]},{"hash":"639010601337079761","title":"Inflammatory eicosanoid biosynthesis","description":"The cluster centers on prostaglandin and leukotriene biosynthesis, leukotriene production in inflammatory response, and acute inflammation, indicating synthesis of inflammatory lipid mediators. Supportive terms like cellular response to calcium ion and cellular oxidant detoxification align with inflammatory signaling and oxidative stress during such responses. A couple of terms on differentiation (Leydig/foam cell) are peripheral to the core inflammatory lipid mediator theme, but do not override the dominant signal.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033327","count":2},{"id":"GO:0010742","count":2},{"id":"GO:0043085","count":1},{"id":"GO:0001516","count":1},{"id":"GO:0071277","count":1}]},{"hash":"511639420891450043","title":"Neural Plasticity and Development","description":"The cluster centers on neuronal plasticity and memory-related processes (long-term potentiation, short-term memory, regulation of neuronal plasticity) and neuron projection development, suggesting a brain-related function. Some terms touch on broader development and mechanical response, but the strongest signal is neural signaling and development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0002027","count":2},{"id":"GO:0001822","count":2}]},{"hash":"1976320143395592154","title":"Cytoskeletal organization and stress responses","description":"This cluster centers on microtubule cytoskeleton organization and spindle assembly, indicating a shared role in cytoskeletal dynamics during cell division and morphogenesis (e.g., lens fiber morphogenesis). The presence of aggresome assembly and ubiquitin/ERAD-related terms, along with apoptosis and oxidative stress responses (H2O2, ROS regulation), suggests coordinated proteostasis and stress signaling that intersect with cytoskeletal remodeling. Collectively, the terms point to a thematic link between cytoskeletal machinery and cellular stress responses, justifying the label.","confidence":"High","size":14,"edges":28,"triangles":15,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070309","count":4},{"id":"GO:0070842","count":3},{"id":"GO:0014070","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0006915","count":3}]},{"hash":"1104250728071075152","title":"Cytoskeletal dynamics and vesicle trafficking","description":"This cluster centers on regulation of cytoskeletal signaling (Rho pathway), membrane trafficking (endocytosis/exocytosis), and related structural processes (myoblast fusion, synapse assembly, centriole elongation). The GO terms collectively point to coordinated cytoskeletal remodeling with vesicle trafficking that underpins cell movement, fusion, secretion, and remodeling of tissues such as muscle, nerves, and vessels. ","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":9},{"id":"GO:0007520","count":8},{"id":"GO:0048260","count":7},{"id":"GO:0002692","count":7},{"id":"GO:0060313","count":7}]},{"hash":"1219233817578646796","title":"RNA Pol III Transcription Machinery","description":"Most terms point to RNA polymerase III activity: preinitiation complex assembly, transcription by Pol III, and 5S rRNA transcription by Pol III. A few other terms (sucrose biosynthesis, glucose response, xenobiotic response, dephosphorylation, skeletal muscle differentiation) are not clearly tied to Pol III and may reflect broader regulation or annotation noise. Overall, the strongest shared function is Pol III\u2013mediated transcription.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":1},{"id":"GO:0000999","count":1},{"id":"GO:0001009","count":1},{"id":"GO:0042791","count":1},{"id":"GO:0001041","count":1}]},{"hash":"1273739610700879459","title":"Unknown","description":"The terms span RNA processing, DNA repair and recombination, redox balance, and several unrelated processes (skin development, aging, migration), with no evident cohesive function or interconnections among proteins (Edges: 0). This makes it inappropriate to assign a specific functional label beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043488","count":2},{"id":"GO:0071044","count":2},{"id":"GO:0045454","count":1},{"id":"GO:0014912","count":1},{"id":"GO:0003335","count":1}]},{"hash":"1758226501382128922","title":"Nonsense-Mediated mRNA Decay (NMD)","description":"The top GO term points to nonsense-mediated mRNA decay, indicating the proteins may participate in NMD and mRNA surveillance; even with no network connections, this functional theme is the most specific common thread among the annotated terms.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":1}]},{"hash":"2194204931890002372","title":"Diverse catabolic metabolism","description":"The top GO terms are dominated by various catabolic processes (triglyceride, phospholipid, stilbene, uracil catabolism) and detoxification-related terms, with one lipid-signaling note (regulation of endocannabinoid signaling). The cluster appears to reflect broad metabolic breakdown and defensive detoxification rather than a single cohesive pathway, which fits the absence of edges and supports a general catabolic/detox theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2000124","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0046839","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0046272","count":4}]},{"hash":"682276143046772672","title":"DNA Transposition Proteins","description":"The strongest GO signal is DNA transposition (4 annotations), suggesting many proteins in this cluster are related to transposable element activity. The other terms are quite diverse (development, redox, mRNA regulation, etc.), so the overall functional theme is not cohesive beyond the transposition signal; the label therefore reflects the dominant signal without overstating overall unity.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:1903527","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0001893","count":2},{"id":"GO:0045598","count":2}]},{"hash":"197615025984720923","title":"Detoxification and xenobiotic metabolism","description":"Despite sparse, varied annotations, most GO terms relate to processing and neutralizing foreign compounds and oxidants (cellular oxidant detoxification, response to toxic substance, prostaglandin and glucuronoside catabolic processes, epoxygenase P450 pathway). A few terms (translation, biotin biosynthesis, stilbene catabolic process) appear peripheral, but the dominant theme centers on detoxification and metabolic processing of xenobiotics/oxidative stress. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0046839","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0046272","count":1},{"id":"GO:0055114","count":1}]},{"hash":"1509918804136823898","title":"Unknown","description":"The top GO terms span embryonic/brain development, endothelial barrier establishment, tissue remodeling (collagen catabolic process, plasminogen activation), signaling (Wnt), digestion, and immune responses (complement activation, LPS response). There is no single dominant function tying all proteins together, and the absence of edges suggests no cohesive interaction network. Therefore, this cluster is best labeled Unknown with no clear representative function.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0030574","count":2}]},{"hash":"1925282814515161436","title":"Nutrient Transport and Sugar Response","description":"The terms cluster around transport of nutrients and related metabolites (potassium, vitamins, dehydroascorbic acid, sugars) and sugar- or energy-related responses (glucose starvation, fructose stimulus), suggesting a coherent theme of membrane transport with metabolic sensing, despite a couple of outliers like mitochondrial fission and protein repair.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000266","count":1},{"id":"GO:0030091","count":1},{"id":"GO:0015671","count":1},{"id":"GO:0042149","count":1},{"id":"GO:0071805","count":1}]},{"hash":"1997704547604647036","title":"Unknown","description":"The top GO terms span diverse processes (DNA repair, redox homeostasis, mRNA stability regulation, signaling, development) with no clear common function, and several terms are marked obsolete. This heterogeneity suggests there isn\u2019t a cohesive, interpretable theme tying the cluster together, so a generic Unknown label is warranted.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2},{"id":"GO:0007568","count":2}]},{"hash":"1642984441911608408","title":"Eye Development and Visual Perception","description":"The top GO terms show a strong emphasis on vision-related biology, with retina development in camera-type eye and visual perception having the highest counts. Neural signaling terms like synapse organization and receptor recycling also align with retinal/visual system activity. While there are other developmental terms (heart, osteoblast) that may reflect broader pleiotropy or data noise, the dominant signal centers on eye/vision development, making this label representative though with some contextual caveats.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0051384","count":3},{"id":"GO:0002076","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0007601","count":3}]},{"hash":"347626882562964155","title":"mRNA decay and translation regulation","description":"This cluster is dominated by GO terms for deadenylation, decapping, and cytoplasmic mRNA turnover, plus translation repression, indicating a cohesive role in RNA processing and control of translation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010606","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0017148","count":1},{"id":"GO:0001829","count":1},{"id":"GO:0000749","count":1}]},{"hash":"1123042304134357929","title":"Immune Receptor Signaling","description":"The top GO terms cluster around immune communication and signaling\u2014adaptive (B cell receptor signaling, Fc-epsilon receptor signaling, IL-2 production) and innate responses\u2014along with KIT signaling and Rho pathway regulation, indicating a cohesive theme of immune receptor\u2013mediated signaling and activation across cell types.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":3},{"id":"GO:0050853","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0038095","count":2},{"id":"GO:1900042","count":2}]},{"hash":"224815007760272362","title":"Muscle contraction and cytoskeletal dynamics","description":"The top GO terms include cardiac muscle development, regulation of skeletal muscle contraction, and actin filament uncapping, all pointing to muscle function and cytoskeletal remodeling. Other terms are more divergent (signaling pathways, mitotic movement), but the strongest cohesive theme centers on muscle-related processes and cytoskeletal regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086097","count":1},{"id":"GO:0035626","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0055013","count":1},{"id":"GO:0014728","count":1}]},{"hash":"866149841917510624","title":"Neural development and survival signaling","description":"Top GO terms center on neural development, signaling, and maintenance, including regulation of PI3K/AKT signaling, positive/negative regulation of neuronal survival, myelination, lens fiber development, olfactory learning, and Hedgehog pathway activity; macroautophagy also ties to neuronal maintenance. This pattern suggests a cluster of proteins involved in neural development and neuron survival signaling rather than a single cytoskeletal or metabolic process.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014065","count":2},{"id":"GO:0016236","count":2},{"id":"GO:0031641","count":2},{"id":"GO:0051897","count":2},{"id":"GO:0043524","count":2}]},{"hash":"805300885414319266","title":"Diverse tissue differentiation","description":"This cluster is characterized by GO terms tied to differentiation across multiple tissues and lineages (lens fiber cell differentiation, spinal cord development, skeletal muscle cell differentiation, and regulation of T cell differentiation). While a few terms touch on apoptosis or neural/immune processes, the strongest recurring theme is cell fate specification and tissue maturation across diverse organ systems, suggesting a broad differentiation-centric cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036268","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0006915","count":1},{"id":"GO:0033081","count":1}]},{"hash":"246047959827874758","title":"Secretory Pathway and ECM Modification","description":"The top GO terms center on ER-Golgi transport and vesicle trafficking between these compartments, plus collagen-related processes such as collagen fibril organization and peptidyl-proline hydroxylation, which is essential for collagen maturation. Pigmentation and intracellular oxygen homeostasis also align with secretory and extracellular matrix-related activities that require oxygen for hydroxylation. A weaker outlier like mitotic spindle assembly may reflect shared cellular machinery rather than a core function. Overall, the cluster appears to be linked to protein handling in the secretory pathway and extracellular matrix modification.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0043473","count":2},{"id":"GO:1901874","count":1}]},{"hash":"1121300359332309561","title":"Unknown","description":"This cluster provides no GO terms to define a shared function, and the graph has no edges or triangles, indicating no apparent connectivity among the proteins. Without a common functional signal, a cohesive label cannot be assigned.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2166882141400861504","title":"Nuclear transport and telomere tethering","description":"The top GO terms center on nuclear pore complex assembly, RNA export (mRNA and tRNA), and nuclear pore localization, together with telomere tethering and chromatin silencing at telomeres, plus nuclear membrane dynamics and a general cellular stress response. This pattern suggests a cohesive cluster of proteins involved in nuclear transport and genome organization at the nuclear periphery, possibly modulated by stress.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051292","count":1},{"id":"GO:0034398","count":1},{"id":"GO:0031990","count":1},{"id":"GO:0007077","count":1},{"id":"GO:0031081","count":1}]},{"hash":"2301155975729955573","title":"Nociception and Thermoregulation with Ion Transport","description":"This cluster centers on GO terms for temperature- and thermogenesis-related responses and pain perception/behavior, paired with ion transport across membranes (manganese and potassium). The combination suggests proteins involved in sensing or responding to temperature and pain while managing ion movement. A few terms (ossification, protein homooligomerization, and receptor signaling regulation) are less clearly connected to this core theme, likely reflecting secondary roles or annotation noise. Overall, the theme is thermoregulation and nociception linked with ion transport.","confidence":"Medium","size":13,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0006828","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0097623","count":3}]},{"hash":"1332361680330823957","title":"Neural signaling and sensory perception","description":"The top terms cluster around neural functions: visual perception and learning, dopaminergic synaptic transmission, behavioral responses to cocaine, sensory perception of pain, and ERK signaling regulation, all pointing to neuronal signaling and sensory processing. A few terms (heart development, abscisic acid-activated signaling) seem less related and may reflect annotation noise or multifunction proteins, but the dominant theme supports a neural/sensory interpretation. ","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0008542","count":8},{"id":"GO:0048148","count":8},{"id":"GO:0071380","count":8}]},{"hash":"692889678401189724","title":"Chromatin Regulation and Nuclear Transport in Cell Division","description":"The cluster\u2019s frequent GO terms point to chromatin remodeling (histone H3 acetylation, chromatin organization, ubiquitination), nuclear transport (nuclear pore localization), and division-related machinery (mitotic spindle, cilium assembly) as core themes, with accompanying vesicle trafficking. Developmental terms like skin/retina development appear but are less central, suggesting a focus on chromatin/nuclear processes linked to cell division and intracellular transport during development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0043588","count":7},{"id":"GO:0070262","count":6},{"id":"GO:0043966","count":6},{"id":"GO:0060271","count":6},{"id":"GO:0031081","count":6}]},{"hash":"348146546828553988","title":"Cell Cycle and Growth Regulation","description":"Top GO terms point to cell cycle progression and growth control (DNA replication, cell division, negative regulation of proliferation, Wnt signaling), with supporting roles in gene expression (mRNA export, transcription elongation) and intracellular trafficking (ER-Golgi transport, mitochondrial import). Together these terms indicate a coordinated program governing cell growth, division, and survival rather than a specific metabolic process. Hence the label 'Cell Cycle and Growth Regulation' captures the cluster's shared function.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0032968","count":3},{"id":"GO:0045041","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006888","count":3}]},{"hash":"735516164395303614","title":"Mitochondrial Transport and Membrane Regulation","description":"The terms are dominated by mitochondrial functions\u2014transmembrane transport of NAD, CoA, and citrate; regulation of mitochondrial membrane potential and permeability; apoptotic mitochondrial changes; and even links to liver growth signals\u2014pointing to a coherent theme of mitochondrial transport/metabolism and membrane regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097274","count":8},{"id":"GO:0097421","count":8},{"id":"GO:0000002","count":7},{"id":"GO:0008637","count":7},{"id":"GO:0046902","count":7}]},{"hash":"1725533873151759757","title":"Eukaryotic Translation Initiation and mRNA Processing","description":"The top GO terms cluster around translation initiation and preinitiation complex assembly (translation reinitiation, preinitiation complex formation, EIF4F complex assembly) and also include mRNA splicing via the spliceosome, indicating a protein set involved in RNA processing and the initiation of translation in eukaryotes. Some obsolete terms appear but do not change the overall theme of RNA processing coupled with translation initiation.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0043966","count":2},{"id":"GO:0000414","count":2}]},{"hash":"424632028022355117","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0060528","count":2}]},{"hash":"108284943292532763","title":"Unknown","description":"The GO terms are diverse (apoptotic process, spindle assembly, telomere maintenance, actin filament bundle assembly, mRNA processing, various developmental processes), and there are no observed interactions (edges) tying them into a single cohesive function. Several terms are obsolete, diminishing interpretability. Because there is no clear shared theme across the cluster, no specific, representative label can be confidently assigned.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0051225","count":1},{"id":"GO:0032212","count":1},{"id":"GO:0051017","count":1},{"id":"GO:0090501","count":1}]},{"hash":"398080751073803506","title":"Muscle sarcomere organization and regeneration","description":"The top GO terms point to muscle structure and repair, notably sarcomere organization, actin filament bundle assembly, and skeletal muscle tissue regeneration. Some terms (e.g., nervous system development, various catabolic processes) appear unrelated or general noise, but the strongest signal centers on muscle structural organization and regeneration.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0050968","count":1},{"id":"GO:0070198","count":1},{"id":"GO:0051017","count":1}]},{"hash":"1625203472713983129","title":"Neural development and synaptic function","description":"This cluster is enriched for neural-related processes, especially regulation of synaptic vesicle exocytosis and excitatory postsynaptic potentials, along with brain development; other terms touch on cell polarity and adhesion that support neuronal architecture, making neural development and synaptic function the best unifying theme.","confidence":"High","size":13,"edges":65,"triangles":174,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000300","count":12},{"id":"GO:0031384","count":12},{"id":"GO:0007420","count":12},{"id":"GO:0010796","count":12},{"id":"GO:0035272","count":11}]},{"hash":"213004855516018547","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0030073","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0006836","count":2},{"id":"GO:0016079","count":2}]},{"hash":"914538276136230965","title":"Ribosome Biogenesis and RNA Processing","description":"The proteins cluster around translation and RNA metabolism, with GO terms for translation, maturation of SSU-rRNA, RNA folding, intron splicing, and regulation of translational fidelity, pointing to ribosome assembly and RNA processing as the core function. Some annotations for formate metabolism, methanogenesis, and flagellum assembly appear as peripheral signals but do not redefine the main theme.","confidence":"Medium","size":13,"edges":36,"triangles":27,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0046677","count":2},{"id":"GO:0034337","count":1},{"id":"GO:0033120","count":1},{"id":"GO:0000462","count":1}]},{"hash":"514242549573997960","title":"RNA silencing and translation regulation","description":"The Top Terms cluster around RNA-based post-transcriptional regulation (miRNA processing, RNA interference, gene silencing) and translation initiation/reinitiation processes, suggesting a cohesive group of RNA processing factors linked to translational control. A few peripheral terms (developmental patterning, defense) are present but do not define the core function, so the dominant theme is RNA silencing together with translation regulation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0050829","count":1},{"id":"GO:0033168","count":1},{"id":"GO:2000011","count":1}]},{"hash":"1067762984437107389","title":"mRNA processing and translational control","description":"The terms point to post-transcriptional regulation, including mRNA splicing, stability and deadenylation, and multiple layers of translation initiation and inhibition (eIF4F assembly, translational regulation, IRES-dependent viral translation, and miRNA-mediated silencing), with viral contexts suggesting broader translational control mechanisms.","confidence":"High","size":13,"edges":14,"triangles":0,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":6},{"id":"GO:0010610","count":6},{"id":"GO:0097010","count":5},{"id":"GO:1902625","count":5},{"id":"GO:0075522","count":5}]},{"hash":"626033674170794273","title":"Skeletal Muscle Differentiation and Sarcomere Organization","description":"The top terms center on skeletal muscle differentiation and sarcomere organization, with additional signals for nervous system development and immune differentiation, suggesting a broader developmental program but with a muscle-centric core.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0007422","count":2},{"id":"GO:0097350","count":2}]},{"hash":"573040244271241165","title":"Glandular Morphogenesis and Epithelial Polarity","description":"The terms point to development and morphogenesis of glands and epithelia (mammary gland duct morphogenesis, Harderian and tracheal tissues) and maintenance of epithelial polarity, with some transcription-related terms that are less central to the theme. This suggests a cohesive theme of gland/epithelial development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060534","count":2},{"id":"GO:0060068","count":2},{"id":"GO:0051091","count":2},{"id":"GO:0060750","count":2},{"id":"GO:0006351","count":2}]},{"hash":"76455654786602383","title":"Neural development and axon guidance","description":"The cluster is enriched for terms related to organismal development and nervous system formation, especially peripheral nervous system development and axon guidance, suggesting a cohesive role in neural patterning. While there are a couple of immune differentiation terms (dendritic cell differentiation, neutrophil clearance) and a translation/transcription term, the strongest signal centers on neural development and morphogenesis.","confidence":"Medium","size":13,"edges":12,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0048701","count":2},{"id":"GO:0035584","count":2},{"id":"GO:0007422","count":2},{"id":"GO:0097350","count":2}]},{"hash":"81505436992545948","title":"Organogenesis and lineage differentiation across tissues","description":"This cluster centers on developmental processes across many tissues\u2014heart valve formation via EMT, skeletal muscle, amacrine retina cells, endocrine pancreas development, and lung vasculature, with hemangioblast differentiation also pointing to vascular lineage. The presence of transcription by RNA polymerase II and its regulation suggests these proteins participate in core gene-regulatory programs that drive diverse differentiation pathways, occasionally modulated by hormones (estradiol). Confidence: High","confidence":"","size":13,"edges":74,"triangles":246,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0060217","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0003199","count":4},{"id":"GO:0071392","count":4}]},{"hash":"297170051464171778","title":"Vacuolar amino acid transport","description":"This cluster is dominated by GO terms for import and export of specific amino acids (serine, alanine, proline, histidine) across the vacuolar membrane, i.e., tonoplast transporters. A couple of unrelated or obsolete annotations (viral release, other transport terms) appear as noise, but the core signal points to vacuolar amino acid transmembrane transport proteins.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":2},{"id":"GO:0071407","count":2},{"id":"GO:0090516","count":1},{"id":"GO:0090452","count":1},{"id":"GO:0015808","count":1}]},{"hash":"106121576925666617","title":"Vascular-immune regulation and lipid metabolism","description":"The cluster is enriched for immune-related processes (adaptive immune response, complement activation) and vascular functions (vasoconstriction, plasminogen activation), suggesting immune/coagulation activity within the vasculature. It also includes lipid metabolism signals (lipoprotein lipase regulation, triglyceride homeostasis) and metabolic signaling (leptin response), pointing to a broader theme of vascular immune regulation intertwined with metabolic processes. There are some unrelated terms (muscle/bone differentiation) that may be peripheral noise. ","confidence":"Medium","size":13,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045907","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0030210","count":3},{"id":"GO:0031639","count":3}]},{"hash":"1587615413523624079","title":"Neuronal signaling and learning","description":"This cluster is dominated by neuronal-related GO terms: visual learning, excitatory postsynaptic potential, and response to cocaine point to synaptic transmission and behavioral responses. The presence of glucose metabolic process and insulin receptor signaling suggests a link to brain energy metabolism, while osmotic stress regulation and thyroid gland development add broader endocrine/homeostatic context. Overall, the proteins likely participate in brain signaling and associated metabolic regulation, though the terms are somewhat diverse, so the connection is present but not extremely tight.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":13},{"id":"GO:0047484","count":13},{"id":"GO:0008285","count":13},{"id":"GO:0060079","count":13},{"id":"GO:0042220","count":13}]},{"hash":"2241896513016121018","title":"Developmental morphogenesis and ribosome biogenesis","description":"Based on GO terms, the cluster centers on developmental processes (skeletal system morphogenesis; spinal cord development; multicellular organism development) with a secondary signal for ribosome biogenesis. The presence of ciliogenesis (cilium assembly) also aligns with development. The combined themes point to developmental maturation with a protein synthesis component.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048705","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0007275","count":2},{"id":"GO:2000616","count":1}]},{"hash":"2250228296166701273","title":"General Stress Response and DNA Repair","description":"The terms point to broad cellular maintenance under stress: stress response, redox homeostasis, and DNA repair, with supporting regulatory processes like mRNA stability. Some entries seem peripheral or cross-species (e.g., corneocyte development, host dormancy), but the core theme centers on stress adaptation and genome maintenance.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2}]},{"hash":"1249901568339492800","title":"Vision-related neural signaling","description":"The top GO terms cluster around vision and neural signaling: visual perception, visual learning, and excitatory postsynaptic potential, with additional references to responses to stimuli such as cocaine, all pointing to neural activity tied to the visual system. Some terms about insulin signaling and cell cycle suggest broader pleiotropy, but the dominant theme across the prominent terms is vision-associated neural signaling.","confidence":"Medium","size":13,"edges":53,"triangles":88,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":13},{"id":"GO:0033160","count":13},{"id":"GO:0000278","count":13},{"id":"GO:0008542","count":12},{"id":"GO:0047484","count":12}]},{"hash":"354932109427819563","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":1},{"id":"GO:0031664","count":1},{"id":"GO:2000637","count":1},{"id":"GO:0070512","count":1},{"id":"GO:0036205","count":1}]},{"hash":"1101595104906711269","title":"DNA repair and telomere maintenance","description":"The top terms center on DNA repair pathways (single-strand break repair, DNA replication-associated elongation, and nonhomologous end joining) and telomere-related chromatin dynamics (subtelomeric heterochromatin formation, regulation of recombination at telomeres). This points to a cohesive theme around genome integrity and telomere maintenance, despite some noisy or obsolete terms in the set. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000012","count":1},{"id":"GO:0006271","count":1},{"id":"GO:0097680","count":1},{"id":"GO:0070512","count":1},{"id":"GO:2000232","count":1}]},{"hash":"2039121916128435183","title":"Neuronal ion transport and pain signaling","description":"The GO terms emphasize ion import/export across the plasma membrane for calcium, sodium, and potassium, which points to neuronal ion channels and transporters governing excitability. Additional terms link to pain perception and startle responses, tying the cluster to nociceptive signaling. The presence of circadian sleep regulation and synaptic potentiation hints at links to synaptic plasticity and rhythmic neuronal activity. Overall, this cluster appears to group proteins involved in neuronal signaling, excitability, and pain-related responses, with some connection to circadian/plasticity processes.","confidence":"High","size":13,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0001964","count":4},{"id":"GO:0045188","count":4},{"id":"GO:0048265","count":3}]},{"hash":"1385858691750722979","title":"Unknown","description":"The top GO terms span neural development (neurogenesis, nervous system development), immune signaling (complement activation, B cell receptor signaling), tissue maintenance (GI epithelium), and structural/remodeling processes (sarcomere organization, proteolysis) along with apoptosis and PI3K-related signaling. This broad mix lacks a single cohesive theme, so a precise, representative label cannot be confidently assigned.","confidence":"","size":13,"edges":43,"triangles":44,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0030277","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0048672","count":2}]},{"hash":"324427143408766684","title":"Cell Cycle Regulation and Growth Signaling","description":"This cluster centers on mitotic control and proliferation (cell cycle, CDK activity, kinetochore localization, negative regulation of proliferation) with accompanying growth-related signaling pathways (insulin signaling, T cell receptor signaling). The co-occurrence of cell-cycle\u2013related terms alongside signaling and differentiation terms suggests a module where cell division is integrated with broader regulatory signals.","confidence":"Medium","size":12,"edges":60,"triangles":169,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":6},{"id":"GO:0045736","count":6},{"id":"GO:0035335","count":6},{"id":"GO:0007049","count":4},{"id":"GO:0008285","count":4}]},{"hash":"1852187123035654085","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001649","count":2},{"id":"GO:0070389","count":2},{"id":"GO:0071374","count":2},{"id":"GO:0071630","count":2},{"id":"GO:0006458","count":2}]},{"hash":"1509525273981423134","title":"Chromatin modification and ribosome biogenesis factors","description":"This cluster is enriched for histone modification terms (H3/H4 acetylation and deacetylation) and ribosome biogenesis (including small subunit biogenesis) as well as RNA guanine-N7 methylation, suggesting roles in regulating chromatin state and ribosome assembly. The presence of cell division and cellular senescence terms may reflect links to cell cycle control, indicating a theme of coordinating gene expression with ribosome production. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0043981","count":2},{"id":"GO:0090398","count":2},{"id":"GO:0051301","count":2}]},{"hash":"272165786450789608","title":"Embryonic Neural and Organ Development","description":"The top GO terms cluster around developmental processes across neural tissues (midbrain-hindbrain boundary morphogenesis, neural retina development, GABAergic interneuron differentiation, auditory receptor cell fate) and organogenesis in heart, bronchioles, and stomach neuroendocrine cells, plus related differentiation events. This suggests a broad embryonic development/differentiation program spanning multiple tissues, rather than a single tissue-specific function.","confidence":"Medium","size":12,"edges":58,"triangles":155,"max_degree":11,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021555","count":12},{"id":"GO:0003407","count":12},{"id":"GO:0021892","count":12},{"id":"GO:0003144","count":12},{"id":"GO:0071392","count":12}]},{"hash":"1441883106952553889","title":"Oxidative Stress Response and Apoptosis","description":"Enriched GO terms point to cellular responses to hydrogen peroxide, redox homeostasis, and apoptotic processes, indicating a core theme of stress-induced signaling and cell fate decisions. Additional terms (cadmium response, hormone stimulus) reflect broader environmental stress signaling, with VEGF signaling and some development terms representing contextual pathways. Overall, the dominant pattern is oxidative stress response coupled with apoptosis, supporting this label.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":3},{"id":"GO:0071375","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0048010","count":2},{"id":"GO:0071276","count":2}]},{"hash":"1017588395358015824","title":"Axonogenesis and Myelination","description":"The top GO terms point to neural development and wiring, with emphasis on axonogenesis, axonal fasciculation, synapse assembly, and myelination, suggesting a cluster of proteins involved in nerve development and maturation. Occasional mentions of otolith morphogenesis and mechanosensory responses support a sensory/neural context, while ubiquitination and innate immune terms appear less central to the main theme. Overall, the dominant signal is neuronal development and myelin-related processes.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007409","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0002322","count":2},{"id":"GO:0071260","count":2}]},{"hash":"613563270956793709","title":"Ubiquitin-Proteasome and Immune Signaling","description":"Cluster is driven by deubiquitination, T cell and Fc receptor signaling, and proteasome-related protein turnover, suggesting a shared role in regulating immune signaling via the ubiquitin-proteasome system. While most terms align with ubiquitin-mediated regulation and immune pathways, a few (like plant hypersensitive response and hypoxia-related transcription) appear less directly connected, likely reflecting broader stress-response annotations. Overall, the theme is ubiquitin-proteasome\u2013mediated control of immune signaling.","confidence":"High","size":12,"edges":46,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0038095","count":8},{"id":"GO:0090263","count":8},{"id":"GO:0010363","count":6}]},{"hash":"2133830294904760538","title":"Embryonic organogenesis and transcriptional regulation","description":"This cluster is enriched for DNA-templated transcription and several organ development/morphogenesis terms (heart development, hindlimb morphogenesis, palate formation, outflow tract morphogenesis, spleen development), suggesting a core role in developmental gene regulation. The presence of histone modification and catabolic processes indicates chromatin-level control of transcription, while signals related to immune pathways (I-kappaB phosphorylation, adaptive immune response) imply broader regulatory integration. Overall, the proteins likely coordinate transcription during embryonic organogenesis with chromatin remodeling components.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0035116","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0003148","count":3},{"id":"GO:0048536","count":3}]},{"hash":"1390295718227377742","title":"mRNA Processing and Translation Initiation Regulation","description":"This cluster\u2019s top GO terms point to regulation of translation initiation (including preinitiation complex formation and translation reinitiation) and IRES-dependent initiation, alongside mRNA export and spliceosome-mediated splicing. The convergence on post-transcriptional control of gene expression\u2014especially at the level of translation initiation and mRNA processing\u2014suggests proteins functioning together in this regulatory layer.","confidence":"High","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":3},{"id":"GO:0075522","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0002188","count":2}]},{"hash":"312773181480941195","title":"Neural development and locomotor behavior","description":"The top GO terms are dominated by locomotory behavior and nervous system development, suggesting a neural/motor function focus for this cluster. A few other terms (metabolic and inflammatory) appear incidental or broader in scope, implying some annotation noise rather than a single cohesive pathway. Overall, the cluster seems representative of neural development and movement-related activity.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0090197","count":1}]},{"hash":"2258211011081144295","title":"Rho signaling-driven morphogenesis and synapse development","description":"Top GO terms indicate a core theme of Rho-mediated signal transduction paired with morphogenetic and synaptic processes (including dendritic spine morphogenesis and protein localization to synapse), alongside developmental terms for heart and skeletal system. While there are outliers like DNA repair, the dominant signal ties cytoskeletal signaling to tissue and neuronal morphogenesis.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007266","count":3},{"id":"GO:0007124","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0019233","count":2}]},{"hash":"662195399154860250","title":"RNA processing and vesicle trafficking with signaling","description":"These proteins cluster around RNA regulation (miRNA processing and RNA localization) and intracellular transport along microtubules, complemented by signaling pathways such as NF-kappaB and calcium release. Some terms (ABA biosynthesis, Purkinje cell organization) may reflect annotation cross-talk or noise, but the core theme points to RNA processing/transport linked with signal transduction.","confidence":"Medium","size":12,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035196","count":3},{"id":"GO:0051209","count":2},{"id":"GO:0051237","count":2},{"id":"GO:0072383","count":2},{"id":"GO:0021693","count":2}]},{"hash":"1605012355800093594","title":"Ubiquitin-Proteasome Regulation of Cell Cycle","description":"Based on the strong representation of ubiquitination-related terms (protein polyubiquitination; positive regulation of ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process) and cell cycle checkpoints (mitotic G1 DNA damage checkpoint signaling, regulation of DNA-templated DNA replication initiation), the cluster appears to be centered on ubiquitin-mediated protein turnover that controls cell cycle progression. Some metal response and synapse assembly terms may reflect broader roles but do not override the core theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":1},{"id":"GO:0071406","count":1},{"id":"GO:0030174","count":1},{"id":"GO:0000209","count":1},{"id":"GO:1902916","count":1}]},{"hash":"2250514321631372930","title":"Cell Cycle and Gene Expression","description":"The terms cluster around mitotic cell cycle, APC/C-dependent catabolic process, cell division, transcription, ribosome biogenesis, and ubiquitination, indicating a core theme of cell proliferation and gene expression regulation. Nervous-system terms (retina development, synaptic plasticity, serotonin secretion) are present but less represented, which may reflect broader roles of these proteins rather than a single neuronal pathway. Given the lack of inter-edge connectivity and the mixed signals, the most coherent label focuses on cell-cycle\u2013 and transcription/translation\u2013related processes.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0051301","count":2}]},{"hash":"417703356176222072","title":"Mesodermal development and cartilage formation","description":"This cluster is strongly linked to mesoderm formation and chondrocyte differentiation, with accompanying extracellular matrix remodeling signals, suggesting roles in skeletal tissue development and ECM dynamics; while some other processes are present (apoptosis, xenobiotic response), the developmental theme is most prominent.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071375","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0010614","count":2}]},{"hash":"1097186871553335909","title":"Brain Development and Neuronal Migration","description":"The cluster is enriched for neural development terms (neuron migration, hippocampus development, substantia nigra development) and actin cytoskeleton regulation at cell-cell junctions, suggesting roles in neural differentiation and movement. Additional trafficking-related terms (Golgi to endosome transport, SRP-dependent protein targeting to membrane) may reflect common membrane targeting processes in developing neurons. Overall, the dominant theme points to brain development with associated cytoskeletal and trafficking activities.","confidence":"Medium","size":12,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0090138","count":2},{"id":"GO:0006895","count":2}]},{"hash":"1522013548796773038","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030836","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0097171","count":1},{"id":"GO:0009244","count":1},{"id":"GO:0071318","count":1}]},{"hash":"636836006445777824","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039702","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0010587","count":2}]},{"hash":"704299851327865520","title":"Immune signaling and Tfh cell differentiation","description":"This cluster shows strong representation of immune-related GO terms: adaptive and innate immune responses, spleen development, and regulation of NF-kappaB and JNK signaling, plus a specific term for T follicular helper cell differentiation. The presence of vitamin D response also aligns with immune modulation. Taken together, the core theme is immune activation and Tfh cell development, justifying the name. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070535","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0048536","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0045087","count":4}]},{"hash":"248860059458591880","title":"Transcription Preinitiation Complex (RNA Pol II/III)","description":"The terms center on transcription initiation and preinitiation complex assembly for RNA polymerase II and III, including DNA-templated transcription, promoter initiation, and start-site selection, indicating proteins that function together in the transcription machinery rather than separate pathways.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":1},{"id":"GO:0090074","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0070898","count":1},{"id":"GO:0006351","count":1}]},{"hash":"857355322269084384","title":"Embryonic organ development","description":"GO terms cluster around embryonic organogenesis across multiple tissues (kidney, spinal cord, lung, placenta, cartilage, sensory hair cells), suggesting a broad role in embryonic tissue development rather than a single pathway.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":5},{"id":"GO:0055114","count":3},{"id":"GO:0048903","count":3},{"id":"GO:0033319","count":3},{"id":"GO:0060428","count":3}]},{"hash":"1507747356906960332","title":"Rho GTPase\u2013driven synaptic plasticity and actin regulation","description":"Enriched GO terms point to Rho GTPase signaling, actin dynamics, and synaptic plasticity, linking cytoskeletal control with neuronal signaling and development.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0060292","count":4},{"id":"GO:1900273","count":4},{"id":"GO:0035176","count":4},{"id":"GO:0050830","count":3}]},{"hash":"1250679307578506819","title":"Unknown","description":"The listed GO terms span immune defense, neural/sensory processes, and endocrine/developmental pathways with no single cohesive function tying them together, suggesting a heterogeneous or noisy cluster rather than a specific shared role. This makes it hard to assign a precise label that represents the cluster\u2019s function.","confidence":"","size":12,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0008542","count":2},{"id":"GO:0047484","count":2},{"id":"GO:0008285","count":2}]},{"hash":"1413587658913015116","title":"Neuronal axon guidance and morphogenesis","description":"The top GO terms cluster around axon guidance and neuronal development: ephrin receptor signaling, Roundabout (Slit-Robo) signaling, positive regulation of axon extension, dendrite morphogenesis, and hippocampus development, with MAPK (ERK/JNK) signaling and focal adhesion-related regulation, all pointing to neural development and neurite outgrowth.","confidence":"High","size":12,"edges":39,"triangles":50,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051893","count":9},{"id":"GO:0043552","count":9},{"id":"GO:0046330","count":9},{"id":"GO:0000186","count":9},{"id":"GO:0035385","count":9}]},{"hash":"953456349984355627","title":"Epithelial junctions and polarity in development","description":"The cluster\u2019s GO terms predominantly point to cell-cell junctions (adherens and tight junctions), polarity establishment/maintenance, and processes like focal adhesion regulation and wound healing, all of which together support epithelial organization and tissue remodeling during development and regeneration. Some items (mitotic spindle assembly, excitatory postsynaptic potential) are broader cellular processes but do not override the central theme.","confidence":"Medium","size":12,"edges":33,"triangles":34,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035272","count":12},{"id":"GO:0060079","count":12},{"id":"GO:0090307","count":12},{"id":"GO:1902766","count":12},{"id":"GO:0035088","count":12}]},{"hash":"1647876412307554815","title":"Multi-tissue Development and Differentiation","description":"The terms cluster around development and differentiation across diverse tissues (immune, neural, cardiac, gland/skin, insect blood cells) with Notch signaling implicated, suggesting a broad developmental/differentiation program rather than a single pathway. The breadth makes a concise, cross-tissue label appropriate.","confidence":"Medium","size":12,"edges":10,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0045061","count":7},{"id":"GO:0090260","count":7},{"id":"GO:0007220","count":7},{"id":"GO:0097150","count":7}]},{"hash":"1357754892992801120","title":"Mitochondrial Energy Metabolism and Translation","description":"Top terms point to mitochondrial energy pathways, with the tricarboxylic acid cycle and mitochondrial translation as core signals, complemented by lipid and amino acid biosynthesis and metabolic signaling via insulin. Some terms relate to general protein assembly and RNA processing, but the central theme remains mitochondrial metabolism and protein synthesis. ","confidence":"High","size":12,"edges":26,"triangles":25,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0032869","count":2},{"id":"GO:0032543","count":2}]},{"hash":"1309184517779167661","title":"Actin Cytoskeleton Regulation","description":"Most terms point to actin dynamics and cytoskeletal remodeling, including regulation of GTPase activity and Arp2/3-mediated actin nucleation, as well as lamellipodium assembly. This suggests a common theme of cytoskeleton organization and signaling rather than a single, cohesive function across all proteins. Some items (DNA transposition, hippocampus development, defense against fungus) appear peripheral, indicating multifunctionality or noise, but the dominant signal is actin regulation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0042989","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0071230","count":2}]},{"hash":"181867340074962078","title":"Innate Immune Activation and Recognition","description":"The GO terms clustered here are dominated by innate immune functions: complement activation via the lectin pathway, phagocytosis recognition, responses to fungal origin, basophil activation, platelets, and regulation of NK cell chemotaxis. The few development-related terms (metanephric kidney structures) appear incidental and do not define a cohesive functional theme for the cluster, which is best captured by immune defense processes.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0006910","count":1},{"id":"GO:0072218","count":1},{"id":"GO:0045575","count":1},{"id":"GO:0071226","count":1}]},{"hash":"1877393041536705722","title":"Drosophila Embryogenesis and Germline Development","description":"This cluster centers on developmental regulation in Drosophila, with terms spanning germline and embryonic processes (preblastoderm mitotic cell cycle, germarium cyst encapsulation, follicle cell stalk formation) and broader differentiation events (granulocyte/macrophage/erythrocyte differentiation; muscle development regulation) as well as transcriptional regulation. The shared theme is participation in embryo and germline development and lineage differentiation rather than a single enzymatic function.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0030713","count":1},{"id":"GO:0048706","count":1},{"id":"GO:0030851","count":1},{"id":"GO:0035190","count":1}]},{"hash":"1993707550500972954","title":"Unknown","description":"The top GO terms span neural development, signaling regulation, reproduction, ion transport, proteolysis, and trafficking, with no single coherent function or pathway linking the proteins. The lack of edges and triangles suggests no tight clustering around a shared biological process, so a clear, representative label isn\u2019t supported.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":2},{"id":"GO:0035332","count":2},{"id":"GO:0007289","count":2},{"id":"GO:0010765","count":2},{"id":"GO:0006508","count":2}]},{"hash":"1640089371841961556","title":"Chromatin Remodeling and Epigenetic Regulation","description":"The top GO terms are dominated by chromatin-related processes: nucleosome disassembly, chromatin remodeling, heterochromatin maintenance, and histone modifications (methylation/demethylation), pointing to a consistent theme of chromatin dynamics and epigenetic gene regulation. Some terms reflect tissue-specific or signaling contexts (mammary gland growth, estradiol regulation, glucocorticoid signaling), but the core signal is chromatin remodeling/epigenetic control. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060763","count":1},{"id":"GO:0006337","count":1},{"id":"GO:2000864","count":1},{"id":"GO:0006344","count":1},{"id":"GO:0006338","count":1}]},{"hash":"1152727299375940095","title":"Bacterial energy metabolism and translation","description":"This cluster emphasizes energy production signals (proton transport, NADH to ubiquinone, respiratory chain assembly) alongside fundamental biosynthetic activities like aminoacyl-tRNA charging, pointing to core metabolic processes including translation. The presence of additional biosynthesis and transcription-regulation terms suggests mixed signals or annotation noise, so the label is a best-fit with Medium confidence. ","confidence":"Medium","size":12,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":2},{"id":"GO:0006120","count":1},{"id":"GO:0034553","count":1},{"id":"GO:0006431","count":1},{"id":"GO:0006423","count":1}]},{"hash":"1978357429781593092","title":"Neuron signaling and transport","description":"The cluster includes GO terms tied to neural processes (visual perception, axonogenesis) and signaling (activation of adenylate cyclase) along with multiple membrane transport terms (potassium, vitamin, xenobiotic transport), suggesting a cohesive theme around neuronal signaling coupled with membrane transport. A couple of terms (bone development, chondroitin sulfate cross-linking) are less connected to neural function and may reflect broader developmental roles or annotation noise.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0042908","count":3},{"id":"GO:0006855","count":3}]},{"hash":"504532132636240068","title":"Neuronal signaling and synaptic plasticity in sensory systems","description":"The terms cluster around neuronal signaling and synaptic function (potassium transport, GPCR glutamate signaling, inhibition of vesicle fusion, excitatory postsynaptic potential) and plasticity (regulation of long-term synaptic plasticity), with sensory system development (anterior/posterior lateral line) and learning behavior (conditioned taste aversion). A couple of outliers (peptidoglycan catabolic process, obsolete MAPK activation) likely reflect annotation noise, but the dominant theme ties to sensory neuron signaling and plasticity.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0031631","count":1},{"id":"GO:0000187","count":1},{"id":"GO:0007196","count":1},{"id":"GO:0048899","count":1}]},{"hash":"3771973320082768","title":"Mitochondrial Protein Import and Membrane Regulation","description":"The top GO terms strongly point to mitochondria, especially protein import into the mitochondrial matrix and regulation of mitochondrial membrane permeability, with supporting hints from redox balance and lipid metabolism; while there are some general or less-specific terms, the mitochondrial signals dominate, suggesting a mitochondria-focused functional cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0090502","count":4},{"id":"GO:0070940","count":3},{"id":"GO:0046902","count":3},{"id":"GO:2000134","count":3}]},{"hash":"1401257148143067728","title":"Unknown","description":"Top GO terms cover lipid signaling, redox balance, development, DNA repair, RNA regulation, and energy metabolism, with no single dominant process linking the proteins. The scattered themes do not point to a cohesive, high-level function, so Unknown is the most appropriate label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046856","count":6},{"id":"GO:0045454","count":5},{"id":"GO:0014912","count":5},{"id":"GO:0003335","count":5},{"id":"GO:0007568","count":5}]},{"hash":"1037601769620906969","title":"Sphingolipid and Fatty Acid Biosynthesis","description":"The top GO terms are dominated by lipid metabolism, including sphingosine and sphinganine biosynthesis/metabolism and monounsaturated fatty acid biosynthetic processes, along with cholesterol esterification. While a few terms touch on immune or developmental roles, the lipid-related annotations form the strongest, most coherent signal across the cluster, suggesting these proteins primarily participate in sphingolipid and fatty acid biosynthesis. ","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":3},{"id":"GO:0016567","count":2},{"id":"GO:1903699","count":2},{"id":"GO:0046512","count":2},{"id":"GO:0034435","count":2}]},{"hash":"733817464184562661","title":"Unknown","description":"The top GO terms are a scattered mix (viral transcription activation, neural retina development, seed dormancy, root meristem identity, jasmonic acid signaling, nucleosome disassembly) with several obsolete terms, showing no dominant shared function or pathway. With no coherent theme and no edges linking terms, a single representative label cannot be justified.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043923","count":1},{"id":"GO:0044109","count":1},{"id":"GO:1900400","count":1},{"id":"GO:0003407","count":1},{"id":"GO:0010231","count":1}]},{"hash":"1950108284021352182","title":"Insect eye and wing development signaling","description":"Top GO terms indicate multiple developmental fates (cone cell fate in the compound eye, wing cell fate specification, spermatid differentiation) and signaling regulation (positive regulation of canonical Wnt signaling, EGFR ligand maturation). Other terms touch on protein processing and stress responses (unfolded protein response, ER-to-cytosol proteolysis), which can underpin developmental programs. The cluster thus appears to group proteins involved in insect developmental patterning and signaling rather than a single narrowly defined function, justifying a label focused on eye/wing development signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904211","count":2},{"id":"GO:0048515","count":2},{"id":"GO:0042676","count":2},{"id":"GO:0032815","count":2},{"id":"GO:0035311","count":2}]},{"hash":"1164841509884981104","title":"Complement Activation and Adhesion in Embryogenesis","description":"This cluster shows strong enrichment for complement activation pathways (classical, alternative, lectin) and positive regulation of membrane attack complex activation, along with adhesion-related terms (cell-matrix and heterophilic cell-cell adhesion) and embryonic development. The dominant signal points to proteins involved in the complement system with roles in developmental adhesion/matrix interactions, though the mix of terms suggests additional processes as well. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006957","count":4},{"id":"GO:0001970","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0007157","count":4}]},{"hash":"1017964783951230806","title":"Eye-antennal disc development (Drosophila)","description":"Top terms strongly point to eye development in Drosophila (eye-antennal disc development, R7 differentiation) with some cell-cycle/morphogenesis terms that may accompany disc growth, suggesting this is a developmental-eye cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042023","count":1},{"id":"GO:1901693","count":1},{"id":"GO:0045678","count":1},{"id":"GO:0016321","count":1},{"id":"GO:0070868","count":1}]},{"hash":"1901527067429109709","title":"Ion Transport and Excitability Signaling","description":"This cluster is dominated by GO terms for chloride transmembrane transport and release of calcium into the cytosol, both central to ionic signaling and excitability in cells such as cardiac SA node tissue. While a few terms touch on pain sensing and immune regulation, the core theme points to ion transport and excitability rather than a single specialized pathway, making this label representative though not perfectly uniform.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902476","count":2},{"id":"GO:0035994","count":1},{"id":"GO:1903444","count":1},{"id":"GO:0071642","count":1},{"id":"GO:0050968","count":1}]},{"hash":"154072808827652832","title":"Embryonic Organogenesis and Tissue Differentiation","description":"The cluster is enriched for multiple developmental processes across different organs (kidney development, digestive tract mesoderm development, endodermal differentiation, inner ear receptor cell differentiation, salivary gland morphogenesis, and metanephric basement membrane development), plus guidance and regulation of cell movement (axon guidance, negative regulation of cell migration, Rho signaling). This coherent theme points to organogenesis and tissue differentiation rather than a single specific function.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033564","count":2},{"id":"GO:0060445","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0035024","count":1},{"id":"GO:0030336","count":1}]},{"hash":"1124803894351257979","title":"Neuronal cytoskeleton and axonal transport","description":"The top GO terms point to microtubule-based movement, intracellular transport within neurons, and neuron projection morphogenesis, indicating a cluster focused on neuronal cytoskeleton dynamics and axonal transport that supports neuron structure and synapse development.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":1},{"id":"GO:0007166","count":1},{"id":"GO:0051965","count":1},{"id":"GO:0051493","count":1},{"id":"GO:0007018","count":1}]},{"hash":"782238247336686973","title":"Ubiquitin-Dependent Immune Signaling","description":"Top GO terms point to ubiquitin-mediated protein turnover (ubiquitin-dependent protein catabolic process; K6-linked ubiquitination; protein autoubiquitination) and immune signaling (positive/negative regulation of TNF signaling; adaptive immune response), with histone catabolic process suggesting chromatin turnover linked to ubiquitination. Additional terms related to antiviral defense (negative regulation of intracellular transport of viral material) reinforce a shared theme of ubiquitin-regulated immune processes. Overall, the cluster appears to center on ubiquitin-dependent control of immune signaling and related chromatin dynamics.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:1903265","count":3},{"id":"GO:0036205","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0051865","count":3}]},{"hash":"495328243370589864","title":"Unknown","description":"The GO terms are highly heterogeneous, including cardiac muscle assembly and hypertrophy alongside vision, plant hormone signaling, neural signaling, and cell cycle, with no single clear common function tying all proteins together. This makes it difficult to assign a cohesive, specific label beyond Unknown.","confidence":"","size":11,"edges":11,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055003","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0007118","count":4},{"id":"GO:0014898","count":4},{"id":"GO:0060079","count":4}]},{"hash":"1898242525745937803","title":"Unknown","description":"The GO terms are highly diverse and span unrelated processes from different kingdoms (viral attachment, proteasome/ubiquitin pathways, chlorophyll biosynthesis, plant and insect development, RNA processing, vascular/bone development, skin cell migration). There is no cohesive functional theme linking these proteins, so a concise, representative label cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046813","count":2},{"id":"GO:0043248","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0015995","count":1},{"id":"GO:0048455","count":1}]},{"hash":"2293528617746996696","title":"Neural and Sensory System Development","description":"The top GO terms cluster around development of the nervous system and sensory organs (forebrain, visual system, retinal ganglion cell axon guidance, inner ear, motor neuron axon guidance). There are also broad organogenesis terms (multicellular organism development) and a few other organ-specific development terms (placenta, thyroid), but the dominant theme is neural/sensory tissue development.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":11},{"id":"GO:0019233","count":7},{"id":"GO:0030878","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0001890","count":6}]},{"hash":"2002791931956810657","title":"RNA processing and translation regulation","description":"This cluster is dominated by GO terms tied to RNA metabolism and control of protein synthesis, including translation, translational initiation, and positive regulation of cytoplasmic translation, as well as deadenylation-dependent mRNA decay and spliceosomal tri-snRNP complex assembly, indicating coordinated RNA processing and translational control. A few terms related to neuronal or muscle differentiation appear peripheral to the main theme. ","confidence":"High","size":11,"edges":14,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0035914","count":1},{"id":"GO:0000244","count":1},{"id":"GO:0014009","count":1}]},{"hash":"1649685681463673552","title":"Calcium-dependent neuronal and muscular signaling","description":"The GO terms cluster around calcium-regulated signaling (regulation of postsynaptic calcium, calcineurin-NFAT signaling, activation of adenylate cyclase, excitatory postsynaptic potential) and extend to neural development and muscle-related processes (astrocyte differentiation, photoreceptor morphogenesis, cardiac hypertrophy, muscle filament sliding). This indicates a cohesive theme of calcium-driven signaling across neural and muscular contexts.","confidence":"High","size":11,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902455","count":1},{"id":"GO:0032972","count":1},{"id":"GO:0042994","count":1},{"id":"GO:0014898","count":1},{"id":"GO:0048708","count":1}]},{"hash":"423122113036212097","title":"Viral Infection and Life Cycle","description":"These GO terms cluster around stages of a viral life cycle\u2014virion assembly, uncoating, and release\u2014and include establishment of proviral latency and host entry, suggesting the proteins participate in virus infection and replication or host-virus interactions. Some terms about chaperone activity and lipid droplets may reflect host cell processes co-opted during infection. Overall, the set points to viral infection pathways rather than cellular housekeeping.","confidence":"High","size":11,"edges":52,"triangles":139,"max_degree":10,"top_function":"protein folding","top_go_terms":[{"id":"GO:0019068","count":4},{"id":"GO:0019076","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0030260","count":3},{"id":"GO:2000276","count":3}]},{"hash":"1647541945653951409","title":"Neural development and synaptic signaling","description":"This cluster is dominated by neural-focused GO terms: excitatory postsynaptic potential, long-term synaptic potentiation, axonogenesis, visual perception, and Schwann cell development, suggesting a core role in neural differentiation and synaptic function. The presence of a phosphorylation regulation term fits neuronal signaling networks. Some terms (mitotic cell cycle, plant ABA signaling) are outliers, but they do not override the prevailing neural theme. ","confidence":"High","size":11,"edges":15,"triangles":16,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":7},{"id":"GO:0010800","count":7},{"id":"GO:0007601","count":7},{"id":"GO:0009738","count":7},{"id":"GO:0000278","count":7}]},{"hash":"1407674150537866607","title":"Neural development and synapse assembly","description":"GO terms point to brain development, inner ear development, locomotory behavior, and positive regulation of synapse assembly, indicating a neural development and synaptic organization theme. Lysosome targeting and Golgi-lysosome transport appear as trafficking-related notes but are secondary to the neural/synaptic signals, supporting a label focused on neural development and synapse assembly.","confidence":"High","size":11,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006622","count":2},{"id":"GO:0090160","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007420","count":2}]},{"hash":"1708271245111398212","title":"mRNA Splicing and Translation Initiation Regulation","description":"This cluster is enriched for spliceosome-driven mRNA processing terms (splicing via spliceosome and regulation of mRNA splicing) along with associations to mRNA stability and poly(A) tail regulation, plus components related to translation initiation (including IRES-dependent initiation). The combination points to a cohesive role in post-transcriptional RNA handling and the control of translation, justifying a label focused on mRNA splicing and initiation regulation.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":7},{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0045292","count":5}]},{"hash":"1078277441296210536","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0031145","count":3},{"id":"GO:0070979","count":3}]},{"hash":"2110822932429872760","title":"Photoreceptor Signaling and Dopaminergic Transmission","description":"These proteins cluster around visual processing and GPCR-mediated signaling, highlighted by visual perception, visual learning, and opsin-mediated signaling terms, along with dopaminergic synaptic transmission and GPCR internalization. This suggests a core theme of neural visual signaling with dopaminergic modulation, with peripheral signals related to broader sensory and reward pathways (e.g., cocaine response). Confidence: Medium","confidence":"","size":11,"edges":24,"triangles":21,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0071502","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0008542","count":7},{"id":"GO:0007601","count":7}]},{"hash":"1684809287310718334","title":"Cerebellar development and neuronal signaling","description":"This cluster is dominated by cerebellar-focused terms: Bergmann glial cell differentiation and cerebellar cortex formation, alongside neuronal signaling features like excitatory postsynaptic potentials and visual learning. Insulin signaling and osmotic stress regulation can relate to brain metabolism and homeostasis, while negative regulation of cell proliferation is a broad developmental theme. Some immune-related terms (T cell receptor signaling) likely reflect annotation overlap rather than a core function of this cluster. Overall, the theme centers on cerebellar development and neural signaling.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008285","count":8},{"id":"GO:0008286","count":8},{"id":"GO:0060020","count":8},{"id":"GO:0048679","count":8},{"id":"GO:0050852","count":8}]},{"hash":"530798409930034517","title":"RNA processing and translation initiation regulation","description":"The proteins here are enriched for mRNA processing and splicing (spliceosome, tri-snRNP assembly, mRNA splicing) as well as components involved in translation initiation (eIF4F complex assembly) and mRNA export. This combination suggests a coordinated role in RNA maturation/export that impacts translation initiation, justifying a label that captures both RNA processing and translation control.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0006406","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0031047","count":2}]},{"hash":"2270950677836464710","title":"Plant Hormone Signaling and Photosynthesis","description":"The top GO terms clearly point to plant-specific processes, notably cytokinin-activated signaling and photosynthesis, with additional hints of gibberellin signaling and growth-related regulation, suggesting a plant-growth regulatory module tied to photosynthetic metabolism. Some terms (e.g., interferon response, prostate development) appear unrelated, likely reflecting annotation noise or cross-species mappings, but the dominant signals support a plant hormone signaling and photosynthetic theme.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009736","count":4},{"id":"GO:0015979","count":4},{"id":"GO:0036494","count":4},{"id":"GO:0030850","count":4},{"id":"GO:0016570","count":4}]},{"hash":"1306879393625159503","title":"Bone and Heart Development with Cell Adhesion","description":"This cluster's GO terms cluster around developmental processes (multicellular organism development; forebrain development; ventricular septum development; ossification and osteoblast differentiation) and cell adhesion functions (integrin-mediated adhesion, endothelial cell-cell adhesion, cell-matrix adhesion). Together, they point to proteins involved in tissue morphogenesis, especially bone formation and cardiac/neural development, coordinated by adhesion signaling. The sensory perception of pain term is less central and likely incidental.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0033627","count":2},{"id":"GO:0071603","count":2},{"id":"GO:0007160","count":2}]},{"hash":"2250585253055710592","title":"Translation initiation and regulation","description":"This cluster's top GO terms revolve around the start and control of protein synthesis, including IRES-dependent viral translation initiation, regulation of translational initiation, and formation of the translation preinitiation complex, pointing to a cohesive function in initiation of translation. A few terms related to development and apoptosis appear but are less central to the dominant translation-focused theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034316","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0075525","count":2}]},{"hash":"546708086182007746","title":"Embryonic heart and mesoderm development","description":"The terms point to development of mesodermal derivatives, including heart development, mesoderm formation, chondrocyte differentiation, and cranial skeleton morphogenesis, suggesting a set of proteins involved in embryonic cardiovascular and skeletal formation. Additional terms for DNA replication, transcription, and fatty acid biosynthesis reflect general proliferation and gene expression during development, while nitric oxide signaling can relate to cardiovascular processes. Overall, the cluster seems to capture embryonic mesoderm and heart formation functions.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071732","count":2},{"id":"GO:0010614","count":2},{"id":"GO:0002062","count":2},{"id":"GO:0001707","count":2},{"id":"GO:0048701","count":2}]},{"hash":"1355219084563498743","title":"EGFR-ERK signaling in development and angiogenesis","description":"The cluster is dominated by GO terms for EGFR signaling, the ERK cascade, small GTPase signaling (including Rho), and cell adhesion (adherens junctions), with development-related terms such as CNS development and ossification, plus angiogenesis. This suggests a cohesive developmental signaling module where EGFR-driven ERK signaling and Rho-family GTPases coordinate adhesion, differentiation, and vascular/neuronal development. ","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007173","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0043552","count":3}]},{"hash":"57318011990983820","title":"Proteostasis and Cell Cycle Regulation","description":"Reasoning: The cluster is dominated by ubiquitin-mediated protein turnover (K11-linked ubiquitination, ubiquitin-dependent proteolysis) and the unfolded protein response, indicating a proteostasis focus. The G1/S transition term ties this to cell-cycle control, suggesting the proteins collectively coordinate protein quality with cell-cycle progression, while developmental terms appear more peripheral. ","confidence":"Medium","size":11,"edges":10,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":3},{"id":"GO:0000082","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0006986","count":2}]},{"hash":"1539393342468662181","title":"Seed Lipid Biosynthesis and Germination","description":"The cluster shows enrichment for fatty acid biosynthetic processes and related lipid metabolism (long-chain/medium-chain fatty-acyl-CoA metabolism, long-chain fatty acid import) along with seed-specific processes (seed coat development, positive regulation of seed germination). While a couple of terms (chromatin remodeling, bioluminescence) are less clearly connected, the dominant theme points to seed lipid synthesis and germination regulation.","confidence":"Medium","size":11,"edges":14,"triangles":4,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":2},{"id":"GO:0008218","count":1},{"id":"GO:0001676","count":1},{"id":"GO:0009234","count":1},{"id":"GO:0010214","count":1}]},{"hash":"1033434996788381049","title":"Unknown","description":"The GO terms are scattered across development (blastocyst formation, retina development, skeletal muscle regeneration, olfactory learning) and metabolism (glycolysis, gluconeogenesis) plus cellular processes (ufmylation, vacuole fusion). There is no single cohesive theme linking these terms, and the lack of edges supports a miscellaneous cluster; hence no clear functional label can be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0060041","count":1},{"id":"GO:0008355","count":1},{"id":"GO:0043403","count":1},{"id":"GO:1903298","count":1}]},{"hash":"264453119276117625","title":"Embryonic Organogenesis and Neural Differentiation","description":"The top GO terms cluster around embryonic development across multiple tissues (eye, pancreas, lung) and neural lineage specification (cerebral cortex interneurons, spinal cord motor neurons, oligodendrocyte fate), suggesting proteins involved in coordinating organogenesis with neural differentiation. The RNA polymerase II transcription term is a general process and does not contradict this developmental theme. Therefore, this label is concise and representative of the cluster\u2019s function.","confidence":"High","size":11,"edges":23,"triangles":20,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0048048","count":8},{"id":"GO:0021892","count":8},{"id":"GO:0060435","count":8},{"id":"GO:0060163","count":8}]},{"hash":"1096063051477952045","title":"Membrane transport and osmotic response","description":"The top GO terms cluster around membrane-associated transport (monoatomic cation transmembrane transport, GABA transport, transepithelial ammonium transport) and energy-coupled processes (proton motive force-driven ATP synthesis), with osmotic stress and some immune signaling terms (nitric oxide biosynthesis, macrophage activation) appearing as secondary connections. This points to a cohesive theme of plasma membrane transport and osmoregulation rather than a single narrow pathway, supporting a membrane-transport/osmotic-response label.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903955","count":2},{"id":"GO:0017183","count":1},{"id":"GO:0099132","count":1},{"id":"GO:0042777","count":1},{"id":"GO:0006809","count":1}]},{"hash":"35217578933452611","title":"NF-\u03baB/TNF signaling regulators","description":"The top terms center on NF-\u03baB activation, I\u03baB phosphorylation, and TNF-mediated signaling, with related JNK pathway regulation, suggesting these proteins collectively modulate inflammatory signaling and immune transcription. A few chromatin-related or immune-recombination terms appear, but the core theme remains NF-\u03baB/TNF pathway regulation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":3},{"id":"GO:0051865","count":2},{"id":"GO:0070535","count":2},{"id":"GO:0070512","count":2},{"id":"GO:0036205","count":2}]},{"hash":"267967316579140236","title":"Neural insulin/IGF signaling and behavior","description":"This cluster is centered on insulin/IGF signaling (insulin receptor and IGF receptor pathways) and downstream metabolic regulation (glycogen synthesis, PI3K-related activity). It also contains neural function terms (grooming behavior, social behavior, excitatory postsynaptic potential), suggesting a link between insulin/IGF signaling and neural behavior. A few terms (tight junction assembly, fatty acid import) are less directly connected and may reflect broader membrane-related processes or annotation noise. Confidence: Medium","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0008286","count":2},{"id":"GO:2000821","count":2},{"id":"GO:0070830","count":2},{"id":"GO:2000463","count":2}]},{"hash":"1651462328121521934","title":"Embryonic organ morphogenesis","description":"This cluster centers on embryonic development across multiple organs\u2014neural tube closure, face and eyelid development, heart (cardiac ventricle morphogenesis), cochlea, digits, lung differentiation, and skin barrier formation\u2014indicating a shared theme of organ morphogenesis during embryogenesis. The presence of nucleosome disassembly and DNA methylation regulation hints at chromatin-based regulation of developmental programs, suggesting these proteins act as regulators of developmental gene expression. Edges are absent, so the link is thematic rather than a single pathway.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":2},{"id":"GO:0006337","count":2},{"id":"GO:0060487","count":1},{"id":"GO:0061436","count":1},{"id":"GO:0044030","count":1}]},{"hash":"1182820969991081879","title":"Notch/Wnt developmental signaling","description":"Proteins in this cluster are enriched for embryonic development and morphogenesis terms, including limb morphogenesis, heart looping, somitogenesis, forebrain development, and the canonical Wnt pathway, along with Notch receptor processing. This points to a group involved in coordinating developmental signaling during embryogenesis. Some terms like oxidative stress response, apoptosis, memory, and translation initiation are more general or supportive, but the core theme remains developmental signaling.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030326","count":2},{"id":"GO:0006979","count":2},{"id":"GO:0007220","count":2},{"id":"GO:0001947","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1032532956217860342","title":"Proteostasis and trafficking","description":"This cluster centers on protein homeostasis and intracellular trafficking. Top GO terms cover responses to misfolded proteins, protein processing, oligomerization, ER-Golgi vesicle transport, and import into the mitochondrial intermembrane space, along with microautophagy and proteasomal degradation. Taken together, these proteins appear to participate in maintaining protein quality, processing, and routing through key cellular compartments.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0018279","count":3},{"id":"GO:0061738","count":3},{"id":"GO:0045041","count":3},{"id":"GO:0016485","count":3}]},{"hash":"496791678457804842","title":"Synaptic plasticity and memory signaling","description":"Based on the GO terms, the cluster centers on neuronal signaling and plasticity: excitatory postsynaptic potentials, calcium and ion transport, long-term potentiation/depression, and memory processes, with additional ties to behavior and dopaminergic responses (amphetamine). The convergence on LTP/LTD and memory-related processes supports labeling this cluster as synaptic plasticity and memory signaling.","confidence":"High","size":11,"edges":15,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0006816","count":4},{"id":"GO:0001975","count":4},{"id":"GO:0007616","count":4},{"id":"GO:0007507","count":4}]},{"hash":"1658778601427571559","title":"Epigenetic Regulation & Chromatin Modification","description":"Most GO terms converge on epigenetic control of gene expression through histone modifications (acetylation and multiple methylation states) and related chromatin remodeling. A few terms about imprinting and heart morphogenesis appear as minor outliers, but the dominant signal is histone-based regulation of transcription.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043045","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0006349","count":1},{"id":"GO:0048298","count":1}]},{"hash":"1888180934761227762","title":"Eye development and visual function","description":"This cluster centers on terms tied to eye and visual system biology, notably retina vasculature development in camera-type eye and visual perception. Supporting terms like endosome to melanosome transport point to pigment-related processes in retinal cells, while Notch signaling and microglia development reflect broader neural/eye development. Some terms (junction assembly, virion attachment) are less directly related, suggesting mixed signals, but the core theme appears to be eye/retina-related function.","confidence":"Low","size":11,"edges":11,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0007601","count":1}]},{"hash":"776631110357534114","title":"Developmental signaling and cell migration","description":"The top GO terms point to embryonic development and morphogenesis (cranial skeletal system development, endodermal fate, papilla formation) as well as cell movement (cell migration) and signaling pathways (GTPase activity regulation, B cell receptor signaling, Wnt-related pathways). This mix suggests a cluster of proteins involved in developmental processes and associated cytoskeletal signaling, with some immune-related terms reflecting broader signaling roles. Overall, a developmental signaling and migration theme fits best, though term diversity lowers specificity.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:1904888","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0061324","count":1}]},{"hash":"1449132118515303431","title":"Dendritic spine development and synaptic assembly","description":"The top terms center on neuron development, synapse assembly, and dendritic spine maintenance, with supporting cytoskeletal and signaling processes, indicating a neuronal synapse/spine\u2013related function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048008","count":2},{"id":"GO:0045216","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0007416","count":2},{"id":"GO:2001286","count":1}]},{"hash":"2011553936412927842","title":"Paranodal and juxtaparanodal axon junctions with Rho signaling","description":"The cluster\u2019s top GO terms converge on localization to paranode and juxtaparanode regions of axons and assembly of related junctions, paired with terms for regulation of Rho (and Ras) signaling, suggesting a role in organizing axon\u2013glia junctions and cytoskeletal dynamics. While a few terms touch broader innate immune responses or development, the dominant theme is axonal junction localization and cytoskeletal regulation, supporting this label.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0046580","count":2},{"id":"GO:0071205","count":2},{"id":"GO:0070830","count":2}]},{"hash":"148787794693993165","title":"Cerebellar neuron development and neuroinflammation","description":"This cluster clearly centers on brain development, with neuron projection development and cerebellar cortex development as prominent terms, suggesting cerebellar neuronal development. The presence of inflammatory and stress-response terms (IL-1 signaling, JNK cascade, ER stress\u2013related apoptosis) indicates accompanying neuroinflammatory or stress signaling. The mix points to a theme of cerebellar neuronal development assembled with neuroinflammatory signaling components, hence the chosen label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0021695","count":2},{"id":"GO:0070498","count":2},{"id":"GO:0046330","count":2}]},{"hash":"862689368453051333","title":"Cellular stress and genome maintenance","description":"This cluster features apoptosis, DNA repair (base-excision), redox homeostasis, regulation of mRNA stability, and signaling terms, plus a couple skin-related processes. The assortment suggests a broad theme of cellular stress responses and genome integrity maintenance rather than a single pathway, though the terms are somewhat heterogeneous across functions.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0014912","count":4},{"id":"GO:0003335","count":4},{"id":"GO:0007568","count":4}]},{"hash":"1421943942121521414","title":"Lipid catabolism and membrane lipid turnover","description":"The proteins are enriched for several lipid/glycerolipid catabolic processes: monoacylglycerol, diacylglycerol, triglyceride, and phosphatidylserine catabolism, suggesting a core role in glycerolipid breakdown and membrane lipid remodeling. A secondary signal is regulation of endocannabinoid signaling, which can relate to lipid-derived signaling molecules. While a few terms (cellulose catabolic, menaquinone biosynthesis, and obsolete processes) are present, the dominant pattern points to lipid catabolism as the defining theme of this cluster.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030245","count":5},{"id":"GO:0052651","count":4},{"id":"GO:0006660","count":4},{"id":"GO:2000124","count":4},{"id":"GO:0019433","count":4}]},{"hash":"1899199642926081801","title":"Chromatin Regulation and Genome Maintenance","description":"The top GO terms cluster around nuclear and chromatin-related processes, including nuclear pore localization, chromatin organization, histone modification, and especially double-strand break repair by homologous recombination, along with protein ubiquitination. These collectively point to genome integrity and chromatin dynamics as the core theme, with related cell-cycle functions like spindle assembly and cilium formation appearing as broader context signals. Overall, the cluster appears centered on nuclear/chromatin maintenance and genome stability.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031081","count":3},{"id":"GO:0035948","count":3},{"id":"GO:0070262","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0060271","count":2}]},{"hash":"426912494348742861","title":"Neural development and synapse organization","description":"The top GO terms center on nervous system development, synapse assembly, and axon-specific localization (e.g., juxtaparanode region, auditory receptor cell development), indicating a core theme of neural development and synaptic organization. Some immune or vascular terms appear as outliers, but the dominant signal supports the neural/synaptic theme. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0043314","count":2}]},{"hash":"1659539952546416928","title":"Neural and cardiac developmental signaling","description":"This cluster features strong representation of nervous system development and heart development, plus pathways like GPCR signaling and small GTPase/Rho signaling, as well as calcium-dependent exocytosis and mitochondrial fission. Together, they point to signaling networks guiding neural and cardiac tissue development and maturation, with supportive roles in trafficking and cytoskeletal dynamics.","confidence":"Medium","size":10,"edges":32,"triangles":62,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":7},{"id":"GO:0007124","count":7},{"id":"GO:0000266","count":7},{"id":"GO:0007213","count":7},{"id":"GO:0007264","count":7}]},{"hash":"1809911210045200639","title":"ECM and Vessel Morphogenesis Regulators","description":"Top GO terms indicate extracellular matrix production and organization (collagen biosynthetic process, collagen fibril organization) alongside vascular development signals (negative regulation of angiogenesis, branching involved in blood vessel morphogenesis), pointing to proteins that contribute to ECM structure and vessel formation; additional terms related to synapse maintenance/assembly may reflect ECM roles in neural contexts, but the core theme is ECM-associated vasculature remodeling.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0006958","count":2},{"id":"GO:0061743","count":2},{"id":"GO:0099558","count":2},{"id":"GO:0001569","count":2}]},{"hash":"2041024707628815347","title":"RNA processing and ribosome biogenesis","description":"Most of the top terms cluster around RNA maturation and protein synthesis: ribosome biogenesis, mRNA processing, translation, snoRNP assembly, and splicing/NMD regulation. This points to proteins involved in RNA metabolism and ribosome/translation machinery, with a few less-related terms (insulin signaling, JNK cascade) that may reflect broader regulatory connections or annotation noise.","confidence":"High","size":10,"edges":41,"triangles":92,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0008286","count":2},{"id":"GO:0035948","count":2},{"id":"GO:0000492","count":2}]},{"hash":"1250745629700649249","title":"Mitotic Regulation and Cytoskeletal Remodeling","description":"This cluster shows enrichment for cell division terms such as mitotic spindle assembly and general cell division, as well as cytoskeletal-related processes like Arp2/3-mediated actin nucleation and cilium assembly. It also includes protein modification pathways (phosphorylation, dephosphorylation, ubiquitination) and nuclear transport components, suggesting a group of proteins coordinating mitosis with cytoskeletal dynamics and protein turnover.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0050731","count":4},{"id":"GO:0051301","count":4},{"id":"GO:2000601","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0070262","count":3}]},{"hash":"1283855692635316441","title":"Transcription Regulation and Development","description":"The cluster is dominated by GO terms for transcription control (negative regulation of transcription by RNA polymerase II; DNA-templated transcription) and cell-cycle-related regulation (positive regulation of CDK activity, cell division), along with several differentiation/d developmental terms (mammary gland alveolus development, Leydig cell differentiation, multi-ciliated epithelial cell differentiation). Although there are additional terms related to stress responses (ER unfolded protein response) and tissue remodeling (liver regeneration, leptin response), the strongest signal ties gene regulation to developmental differentiation, suggesting proteins that modulate transcription during development. ","confidence":"Medium","size":10,"edges":29,"triangles":34,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0045737","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0060749","count":5},{"id":"GO:0051301","count":5}]},{"hash":"463341793811123714","title":"RNA processing and translation initiation regulation","description":"This cluster is enriched for GO terms linked to mRNA export, splicing, and translation initiation/reinitiation, plus regulation of translational initiation and ncRNA-mediated gene silencing. Together these terms point to a cohesive theme of RNA processing and control of protein synthesis, rather than a single isolated function.","confidence":"High","size":10,"edges":9,"triangles":4,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":6},{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0006446","count":4},{"id":"GO:1900363","count":4}]},{"hash":"564358616730436975","title":"Unknown","description":"The top GO terms are a mix of diverse metabolic biosynthesis (porphyrin, serine, aromatic amino acids), basic metabolism (pentose-phosphate shunt), chromatin modification (obsolete histone acetylation/methylation), circadian rhythm, immune Switching to IgA, and potassium transport, with no clear single function linking the cluster. This suggests no coherent theme, so label Unknown with none confidence. ","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006813","count":2},{"id":"GO:0006782","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0048298","count":1},{"id":"GO:0009073","count":1}]},{"hash":"571156853436055244","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster around ribosome production and function: translation, maturation of rRNA species, ribosome biogenesis, ribosomal subunit assembly, and translational initiation. This strongly indicates proteins involved in assembling ribosomes and carrying out protein synthesis. A couple of other terms (cell cycle regulation, p53 signaling) are present but infrequent, so the dominant theme remains ribosome-related. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000462","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000466","count":2},{"id":"GO:0006413","count":2}]},{"hash":"405854068771752284","title":"Synaptic signaling and visual system development","description":"This cluster is dominated by neural/synaptic functions (excitatory postsynaptic potential, regulation of exocytosis, postsynaptic calcium) and visual system terms (photoreceptor morphogenesis, visual perception), with astrocyte differentiation supporting CNS context. A few outlier muscle-related terms are present but do not override the primary neural-visual theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0045921","count":4},{"id":"GO:0032972","count":3},{"id":"GO:0042994","count":3},{"id":"GO:0014898","count":3}]},{"hash":"2170322195198698351","title":"Unknown","description":"The top GO terms span redox homeostasis, skin/corneocyte development, aging, mRNA stability, lipid signaling, DNA repair, and other divergent processes, with no clear, single functional theme linking them. This appears to be a heterogeneous cluster without a coherent common function.","confidence":"","size":10,"edges":5,"triangles":0,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":6},{"id":"GO:0014912","count":6},{"id":"GO:0003335","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0043488","count":6}]},{"hash":"2265635144931874392","title":"Cytokine signaling and GPCR-mediated inflammation","description":"The set centers on immune signaling, including regulation of IL-6 and IL-1\u03b2 production and eosinophil chemotaxis, as well as histamine response and GPCR-related pathways (adenylate cyclase activation/inhibition, MAPK-activating adrenergic and dopamine receptor signaling). While a couple of terms (saliva secretion, visual learning) are less aligned, the dominant pattern points to inflammatory cytokine regulation combined with GPCR-driven signaling.","confidence":"Medium","size":10,"edges":10,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0032675","count":1},{"id":"GO:0046541","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0071883","count":1},{"id":"GO:0034776","count":1}]},{"hash":"1393092592217191943","title":"Ubiquitin/SUMO Proteostasis and ERAD","description":"This cluster is dominated by terms linked to protein quality control, including aggresome assembly, ubiquitin-dependent ER-associated degradation (ERAD), and protein sumoylation, pointing to a theme of proteostasis. Some terms (like NER and cell division) are less directly connected and may reflect broader or secondary roles, but the core signals point to ubiquitin/SUMO-regulated protein turnover and misfolded protein handling.","confidence":"High","size":10,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070842","count":3},{"id":"GO:1903071","count":3},{"id":"GO:0016925","count":3},{"id":"GO:0006289","count":3},{"id":"GO:0030433","count":3}]},{"hash":"869591931206147946","title":"Chromatin remodeling and DNA packaging","description":"The terms cluster mainly around chromatin dynamics and nuclear DNA processing: histone exchange, nucleosome mobilization, nuclear speck organization, and regulation of chromosome segregation, along with DNA replication regulation and UV-damage excision repair. Sperm DNA condensation/decondensation also ties to chromatin packaging, reinforcing a common theme of nuclear chromatin architecture and genome maintenance, even though a few terms are more peripheral (circadian clock compensation, hematopoietic differentiation). Overall, the set points to chromatin remodeling and DNA packaging as the core function of this cluster.","confidence":"Medium","size":10,"edges":15,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010378","count":1},{"id":"GO:0002244","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0035092","count":1},{"id":"GO:0070914","count":1}]},{"hash":"1326566311804224955","title":"Immune cell signaling and vesicle trafficking","description":"The top GO terms cluster around immune regulation (positive regulation of T-helper 1 differentiation, neutrophil clearance/apoptotic processes) and vesicle trafficking/cytoskeleton functions (actin cytoskeleton reorganization, receptor recycling, vesicle fusion). While a few terms concern developmental or hormonal contexts, the majority point to immune cell signaling and membrane trafficking, suggesting a cohesive theme of immune regulation coupled with vesicle dynamics.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":2},{"id":"GO:0048146","count":2},{"id":"GO:0001921","count":2},{"id":"GO:0045627","count":1},{"id":"GO:0031340","count":1}]},{"hash":"1315621776328412566","title":"Actin- and Clathrin-Mediated Vesicle Trafficking","description":"The terms cluster around actin cytoskeleton dynamics (Arp2/3 regulation, actin cortical patch assembly) and various vesicle trafficking processes (clathrin-dependent endocytosis, clathrin coat assembly, endosome-to-Golgi transport, synaptic vesicle maturation, vacuole targeting). Together, they point to a theme of coordinating actin-driven membrane remodeling with vesicle formation and transport across endocytic, Golgi- and vacuolar pathways.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034316","count":1},{"id":"GO:0055123","count":1},{"id":"GO:1902963","count":1},{"id":"GO:0072583","count":1},{"id":"GO:0034498","count":1}]},{"hash":"1999928403739414822","title":"Neural and inner ear development","description":"The top terms cluster around neural and sensory development\u2014brain development, neuron cell-cell adhesion, sensory perception of sound, inner ear development, and locomotory behavior\u2014pointing to neural and auditory system formation and function. Some terms (plasminogen activation, triglyceride homeostasis, negative regulation of lipoprotein lipase activity) appear peripheral to this theme, suggesting either broad annotations or incidental overlap.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007158","count":3},{"id":"GO:0090009","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0007420","count":2}]},{"hash":"987864946151111874","title":"Neuromuscular development and junction organization","description":"This cluster combines terms related to muscle-nerve development (neuromuscular process controlling balance; skeletal muscle satellite cell migration), synaptic signaling (excitatory postsynaptic potential), and cell\u2013cell/matrix adhesion and polarity (adherens junction organization; regulation of focal adhesion assembly; establishment/maintenance of apical/basal polarity), with Rab-mediated trafficking. The mix centers on muscle and neuronal development together with junctional and polarity dynamics, supporting a cohesive label around neuromuscular development and junction organization.","confidence":"High","size":10,"edges":21,"triangles":9,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050885","count":5},{"id":"GO:0032482","count":5},{"id":"GO:0050771","count":5},{"id":"GO:0035272","count":4},{"id":"GO:0060079","count":4}]},{"hash":"456487928352546444","title":"Chromatin Remodeling in Embryonic Heart Development","description":"The cluster is driven by chromatin-related processes\u2014histone ubiquitination/acetylation, histone exchange, and transcription initiation\u2014along with polyubiquitination and centrosome/cell cycle activity. These patterns point to coordinated chromatin regulation of gene expression during embryonic development, including heart morphogenesis such as right ventricular development. ","confidence":"High","size":10,"edges":11,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000209","count":4},{"id":"GO:0010571","count":4},{"id":"GO:0007098","count":4},{"id":"GO:0048568","count":4},{"id":"GO:0071894","count":3}]},{"hash":"867573617540821142","title":"Developmental Transcriptional Regulation","description":"The cluster centers on transcriptional control (negative regulation and DNA-templated transcription) with hormone response and multiple developmental contexts (lens, glial, trachea cartilage, embryonic digestive tract morphogenesis), suggesting proteins coordinating transcriptional programs during development and differentiation.","confidence":"Medium","size":10,"edges":36,"triangles":60,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071353","count":8},{"id":"GO:0000122","count":6},{"id":"GO:0006351","count":6},{"id":"GO:2001111","count":6},{"id":"GO:0060534","count":5}]},{"hash":"1536180565693309383","title":"Embryonic Organogenesis","description":"The GO terms cluster around development of diverse organs and tissues in the embryo\u2014kidney (metanephric), spine, cartilage, placenta, lung epithelium, hair cell differentiation, and duct development\u2014indicating a general theme of embryonic organ formation rather than a single pathway.","confidence":"Medium","size":10,"edges":8,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":1},{"id":"GO:0048903","count":1},{"id":"GO:0033319","count":1},{"id":"GO:0060428","count":1},{"id":"GO:0042994","count":1}]},{"hash":"733532135870579987","title":"Neural Sensory Processing and Behavior","description":"The top GO terms cluster around neural sensing and processing: pain perception, temperature response, visual perception and learning, dopaminergic synaptic transmission, cocaine-related behavioral responses, prostaglandin signaling, and ERK cascade regulation. This suggests a function in neural sensation and the resulting behaviors.","confidence":"Medium","size":10,"edges":25,"triangles":29,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0046541","count":4},{"id":"GO:0008542","count":4}]},{"hash":"2274744231490781721","title":"Neuronal development and synaptic vesicle clustering","description":"These proteins show enrichment for neural development and synaptic functions, highlighted by GO terms like positive regulation of synaptic vesicle clustering, nervous system development, and cerebral cortex development, suggesting roles in synapse organization during brain development. Some terms relate to general cellular processes (cell cycle, cytokinesis, sarcomere organization, redox/homeostasis, mitochondrial membrane permeability), but the neural development/synaptic cluster theme is the strongest signal.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000809","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0000910","count":2},{"id":"GO:0021987","count":2}]},{"hash":"415167660972777422","title":"Embryonic organogenesis and morphogenesis","description":"The top GO terms are centered on embryonic development and morphogenesis across multiple organs (eye, pancreas, lung, digestive tract, ureteric bud, neural crest). This points to a common theme of organ formation during development, with some transcriptional regulation terms accompanying the process. Confidence: Medium","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":4},{"id":"GO:0048557","count":3},{"id":"GO:0043010","count":3},{"id":"GO:0090190","count":3},{"id":"GO:0048048","count":3}]},{"hash":"418699080151212390","title":"Spermatogenesis and male gonad development","description":"This cluster is strongly enriched for GO terms related to male gonad development and spermatogenesis, with supporting chromatin-related terms (transcription regulation by RNA Pol II and protein localization to chromatin), indicating a core role in germ cell development and gene expression control. Some terms point to broader developmental and immune processes, but the reproductive development signal is the strongest.","confidence":"Medium","size":10,"edges":28,"triangles":35,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0008584","count":6},{"id":"GO:0007283","count":6},{"id":"GO:0071169","count":5},{"id":"GO:0031639","count":4}]},{"hash":"323411482712600141","title":"GABAergic Synapses and Neurotransmission","description":"The top GO terms converge on neural signaling, especially inhibitory GABAergic transmission: GABA receptor clustering and inhibitory postsynaptic potential, plus calcium and potassium ion transport that govern synaptic activity. Behavioral associations (startle response, conditioned taste aversion, nicotine response) and circadian sleep regulation point to neuronal circuits where GABAergic signaling modulates activity. Developmental and other context terms (optic nerve morphogenesis, amyloid fibril formation regulation) are compatible with neural tissue. Overall, the cluster seems focused on GABAergic synaptic function in neurons.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0001964","count":5},{"id":"GO:0045188","count":5},{"id":"GO:1905906","count":4}]},{"hash":"1608155354506845849","title":"Smooth and cardiac muscle differentiation","description":"The GO terms most represented are smooth muscle cell differentiation, vascular smooth muscle differentiation, and ventricular cardiac muscle cell differentiation, pointing to muscle-development processes. Other terms touch general cellular processes and a few outliers, but the dominant signal aligns with differentiation of muscle lineages.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":1},{"id":"GO:0055012","count":1},{"id":"GO:0097680","count":1},{"id":"GO:0035886","count":1},{"id":"GO:2000721","count":1}]},{"hash":"441389579178143217","title":"ECM remodeling and migratory signaling","description":"The terms point to extracellular matrix organization and turnover (collagen fibril organization, proteolysis, proteoglycan catabolic process) along with regulation of cell adhesion and keratinocyte migration, suggesting remodeling of the ECM to influence cell movement. Also present are signaling-related terms (BMP stimulus response, Notch receptor processing) that can guide these migratory and remodeling processes, with additional but ancillary hints of immune and platelet regulation, supporting a broader tissue remodeling and cell-migration theme.","confidence":"Medium","size":10,"edges":13,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0001953","count":1},{"id":"GO:0071773","count":1},{"id":"GO:0051549","count":1},{"id":"GO:0007220","count":1}]},{"hash":"1853739161112058893","title":"Phosphorylation Signaling Regulators","description":"This cluster centers on GO terms related to regulation and dephosphorylation of phosphorylation events and cGMP/guanylyl cyclase signaling, suggesting proteins that modulate phosphorylation-dependent signaling pathways. Though other terms touch on development or neuronal processes, the dominant theme is regulation of phosphorylation signaling, making this a concise, representative label.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010801","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0071321","count":2},{"id":"GO:0010754","count":2},{"id":"GO:0007608","count":2}]},{"hash":"236394235377068686","title":"Neuronal ion channels and excitability","description":"This cluster centers on calcium and potassium ion transport, voltage-gated calcium channels, and neuronal action potentials, tying the GO terms for startle, locomotory behavior, pain perception, and circadian/sleep regulation together as neural signaling and excitability that drive behavior and state changes.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":6},{"id":"GO:0001964","count":6},{"id":"GO:0045188","count":6},{"id":"GO:0071805","count":5},{"id":"GO:0071502","count":4}]},{"hash":"1219307381749829481","title":"Unknown","description":"The GO terms cover immune response (adaptive immunity, defense against bacteria), development (multicellular organism development, heart development, angiogenesis), and broad signaling processes (Rho and ERK cascades) with no single unifying function, making a cohesive label unlikely.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0061000","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0070374","count":2}]},{"hash":"1209318913422048103","title":"Monoamine neurotransmission and brain development","description":"The top GO terms cluster around neural development (thalamus and adenohypophysis development) and monoamine signaling (serotonin secretion and uptake, dopamine catabolic process), with a note of glial growth. Despite a few general or tangential terms (glycosylation, proline transport), the dominant theme points to brain development and monoaminergic regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":2},{"id":"GO:0015824","count":1},{"id":"GO:0014064","count":1},{"id":"GO:1905847","count":1},{"id":"GO:1903346","count":1}]},{"hash":"81076720471063266","title":"TNF/NF-\u03baB signaling and chromatin regulation","description":"This cluster\u2019s top GO terms cluster around tumor necrosis factor signaling, NF-\u03baB pathway regulation (I-kappaB phosphorylation), JNK cascade control, and histone modification processes, plus a note on immune-related activities like V(D)J recombination and antiviral transport regulation. Together, these points suggest a theme of immune signaling coupled with transcriptional and chromatin regulation, rather than a single metabolic or structural module. Confidence: Medium","confidence":"","size":10,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0070512","count":3},{"id":"GO:0036205","count":3},{"id":"GO:1903721","count":3}]},{"hash":"1964485802598709014","title":"Neuronal signaling and neuromuscular junction organization","description":"The top GO terms are dominated by nervous system\u2013related processes: glutamatergic synaptic transmission, neuron cell\u2013cell adhesion, acetylcholine-gated channel clustering at the neuromuscular junction, and sensory perception of sound, along with regulation of action potentials in muscle. While some immune and developmental terms appear, the strongest signal points to neural communication and NMJ organization, justifying this as the cluster\u2019s main theme.","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0098911","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0007158","count":2}]},{"hash":"1421509026401744301","title":"Unknown","description":"The top GO terms are highly diverse, spanning cell signaling, synapse assembly, metabolism, and chromatin-related processes, with several terms marked obsolete. There is no coherent, single-function theme uniting these terms for this cluster, so the safe label is Unknown and the confidence is None.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":1},{"id":"GO:0007166","count":1},{"id":"GO:0051965","count":1},{"id":"GO:2001172","count":1},{"id":"GO:1903212","count":1}]},{"hash":"2025138700324653472","title":"Neurotransmission and Neuromodulation","description":"The top GO terms cluster around neuronal signaling and neurotransmitter processes (excitatory postsynaptic potential, serotonin metabolism, morphine response, cerebellar granule cell differentiation), pointing to synaptic activity and neuromodulation as the core theme. Some terms reflect broader cellular regulation (cell cycle, ubiquitination, xenobiotic response), but they are secondary to the neuronal signaling signals. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0043278","count":2},{"id":"GO:0042428","count":2},{"id":"GO:0045737","count":2}]},{"hash":"1469658849129031980","title":"Unknown","description":"The top GO terms span sensory perception (sound/auditory) and a variety of unrelated processes (translation, immune regulation, epithelial polarity, cell junctions), with no clear, shared biological function linking the cluster. The lack of edges/triangles also suggests no cohesive interaction pattern to define a specific function. Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0045075","count":1},{"id":"GO:1901206","count":1},{"id":"GO:0071896","count":1}]},{"hash":"1793686608839858055","title":"Unknown","description":"The top GO terms span diverse processes (redox homeostasis, RNA stability, development, aging, DNA repair, signaling, metabolism) with no clear shared function linking all proteins. Without a cohesive theme, a concise label is not supported.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0014912","count":3},{"id":"GO:0003335","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0043488","count":3}]},{"hash":"405820016258290978","title":"Cell fate and genome maintenance","description":"A core theme includes apoptotic process, regulation of G1/S transition, and base-excision repair, pointing to cell fate decisions and genome integrity maintenance. Additional terms for redox homeostasis, mRNA stability, and signaling indicate broader stress response and regulation of cell state, while some terms relate to tissue differentiation. Together, they suggest a cluster centered on cell fate decisions coupled with genome maintenance mechanisms.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:1900087","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0014912","count":3}]},{"hash":"455443906696680676","title":"Unknown","description":"The top GO terms include morphine response, insulin stimulus, cell division, and a variety of metabolic biosynthetic processes (pyruvate, 2-oxobutyrate, serine, homocysteine, cyanide, coenzyme M) with no single cohesive function tying them together. This scattered mix suggests no clear shared molecular role for the cluster as a unit.","confidence":"","size":10,"edges":28,"triangles":36,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042866","count":2}]},{"hash":"509155901941666889","title":"Epithelial microvilli and brush-border assembly","description":"This cluster is dominated by GO terms about microvillus organization and brush border assembly (e.g., terminal web assembly, follicle cell microvillus organization, brush border assembly) and by epithelial dynamics (development, EMT, cell migration, substrate attachment). Together these suggest a shared function in establishing and maintaining epithelial surface structure and polarity, particularly the microvilli/brush-border apparatus and related morphogenetic processes. Some peripheral terms (nitric-oxide regulation, equilibrioception) are less central to the core theme but do not override the main epithelial surface architecture signal.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051000","count":3},{"id":"GO:1902896","count":3},{"id":"GO:0050957","count":3},{"id":"GO:0032529","count":3},{"id":"GO:1904970","count":3}]},{"hash":"2079243182088531462","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904876","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0006370","count":1},{"id":"GO:0000494","count":1},{"id":"GO:0097309","count":1}]},{"hash":"150039350694180999","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0036494","count":1}]},{"hash":"353460474940287010","title":"Translation initiation and mRNA regulation","description":"The top GO terms cluster around eIF4F complex assembly and regulation of translational initiation, plus RNA processing and export activities (splicing, poly(A) tail regulation, mRNA export) and even miRNA-mediated translation silencing, all pointing to coordinated control of translation initiation and RNA metabolism.","confidence":"High","size":10,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097010","count":2},{"id":"GO:1902625","count":2},{"id":"GO:0075522","count":2},{"id":"GO:1903586","count":2},{"id":"GO:0060211","count":2}]},{"hash":"93616966826379411","title":"Unknown","description":"The top GO terms cover many unrelated areas: redox homeostasis, regulation of smooth muscle migration, skin (corneocyte) development, aging, mRNA stability, phosphatidylinositol signaling, base-excision repair, cross-organism hemolysis, DNA recombination, and glycogen synthase regulation. There is no single cohesive biological theme linking these terms, so the cluster appears functionally heterogeneous rather than representing a specific pathway.","confidence":"","size":10,"edges":20,"triangles":16,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":8},{"id":"GO:0014912","count":8},{"id":"GO:0003335","count":8},{"id":"GO:0007568","count":8},{"id":"GO:0043488","count":8}]},{"hash":"1974729382851785027","title":"Unknown","description":"Top GO terms are scattered across distinct biological areas (redox balance, DNA repair/recombination, mRNA stability, lipid signaling, skin cell development, aging, and glycogen regulation). The lack of a unified functional theme makes it hard to assign a precise label, suggesting this cluster is heterogeneous or that annotations reflect multiple roles across proteins.","confidence":"","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":6},{"id":"GO:0014912","count":6},{"id":"GO:0003335","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0043488","count":6}]},{"hash":"41810875702400036","title":"Innate Immune Activation and Vascular Response","description":"The cluster's dominant GO terms point to innate immune and vascular functions: platelet activation, lectin pathway complement activation, basophil activation, phagocytosis recognition, response to fungal origin, and vasoconstriction. Together these suggest proteins involved in immune signaling and inflammatory vascular responses, rather than a single developmental program; a few unrelated kidney development terms may be incidental annotations. Thus the label captures the core theme of innate immune and vascular activity.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":4},{"id":"GO:0001867","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0006910","count":2},{"id":"GO:0072218","count":2}]},{"hash":"1747980744998878398","title":"Immune-Metabolic Signaling","description":"The proteins cluster around immune-related processes (complement activation via lectin pathway; adaptive immune response) and metabolic regulation (triglyceride homeostasis; leptin response; regulation of lipoprotein lipase activity), with supporting signals in tyrosine kinase activation and extracellular matrix/remodeling pathways (heparin proteoglycan biosynthesis; plasminogen activation). This suggests a theme of cross-talk between immune function and metabolism, rather than a single narrow function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0007171","count":4},{"id":"GO:0030210","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0051005","count":2}]},{"hash":"1940348734951278781","title":"Potassium Ion Transport and Membrane Potential","description":"The cluster is dominated by GO terms for potassium ion import/export, transmembrane transport, and membrane repolarization, pointing to proteins that regulate intracellular K+ and cellular excitability. A few terms touch on temperature or pain, but potassium homeostasis and membrane potential appear to be the unifying theme.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0030007","count":4},{"id":"GO:0042493","count":3}]},{"hash":"1714899228717516939","title":"Mitotic cell division and growth machinery","description":"The top GO terms cluster around mitosis and cell proliferation (mitotic spindle assembly, mitotic cell cycle, cell division, cell population proliferation, multicellular organism growth). Additional enrichment for ribosome biogenesis and COPII vesicle trafficking suggests links to overall cellular growth and protein processing. Together, these indicate proteins involved in driving cell division and growth, rather than a single isolated pathway, despite no observed interactions in this cluster.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042254","count":4}]},{"hash":"666408879199516805","title":"RNA Processing and Transcription Termination","description":"This cluster is dominated by RNA metabolism-related GO terms: transcription termination, tRNA processing, spliceosome assembly, and mRNA decay, indicating a core RNA processing module. Some chromatin-related and stress-response terms (pericentric heterochromatin formation, histone mRNA metabolism, ABA response) likely reflect transcription regulation and stress-induced chromatin changes linked to RNA processing.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":7},{"id":"GO:0009414","count":6},{"id":"GO:0008033","count":6},{"id":"GO:1990141","count":6},{"id":"GO:0008334","count":6}]},{"hash":"1452954574289835556","title":"Cell signaling and transcriptional regulation","description":"The cluster includes terms tied to signaling at the cell surface and postsynaptic compartments (excitatory postsynaptic potential, regulation of postsynaptic Ca2+), adhesion and remodeling (cell-cell adhesion, epithelial to mesenchymal transition), and nuclear/dimerization processes (transcription termination by RNA Pol II, regulation of chromatin binding, G1/S cell cycle transition). It also encompasses broad stress and response pathways (response to cocaine, cardiac hypertrophy in response to stress). Taken together, these GO terms point to a network connecting signal reception to transcriptional and chromatin-level responses and structural remodeling, justifying a label around cell signaling and transcriptional regulation. ","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070262","count":9},{"id":"GO:0014898","count":9},{"id":"GO:0098609","count":9},{"id":"GO:0060079","count":9},{"id":"GO:0030846","count":9}]},{"hash":"1256337229940667256","title":"Immune-ECM Adhesion and Remodeling","description":"The cluster shows a cohesive theme of immune signaling (T cell activation via TCR, lectin complement activation, integrin signaling, platelet activation) together with extracellular matrix processes (hyaluronan metabolism, metallopeptidase activity, ECM assembly regulation, cell\u2013ECM and cell\u2013cell adhesion). This suggests proteins function together in immune cell adhesion/communication with the ECM and in remodeling of the extracellular environment during immune responses.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030212","count":5},{"id":"GO:0007229","count":5},{"id":"GO:0002291","count":4},{"id":"GO:1905050","count":4},{"id":"GO:0001867","count":4}]},{"hash":"751915482858174694","title":"Ribosome Biogenesis and Translation","description":"This cluster is highlighted by core ribosome-related processes: ribosome biogenesis and translation, with box C/D snoRNP assembly pointing to RNA processing essential for rRNA maturation. TOR signaling (TORC1/2) links nutrient sensing to ribosome production and protein synthesis, supporting a cohesive theme of ribosome assembly and translational control, while other GO terms hint at broader nuclear/cell-cycle connections.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072443","count":1},{"id":"GO:0007004","count":1},{"id":"GO:1904515","count":1},{"id":"GO:0034502","count":1},{"id":"GO:1904263","count":1}]},{"hash":"373968280732300794","title":"Neural development and axon guidance","description":"Genes in this cluster are enriched for nervous system development and axon guidance terms (forebrain development, axonogenesis, motor neuron axon guidance, lateral motor column neuron migration, retinal ganglion cell axon guidance), indicating a cohesive role in neural circuit formation. Some outlier terms (platelet aggregation, poly-hydroxybutyrate biosynthetic process) likely reflect unrelated functions or noise. Overall, the cluster centers on neural development and axon pathfinding.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042619","count":4},{"id":"GO:0048936","count":3},{"id":"GO:0008045","count":3},{"id":"GO:0097477","count":3}]},{"hash":"1379655658944210250","title":"Cardiac electrophysiology and calcium handling","description":"Most of the top GO terms point to cardiac function, notably regulation of atrial and SA node action potentials and positive regulation of cardiac muscle hypertrophy in response to stress, as well as release of calcium from the sarcoplasmic reticulum. Together, these features suggest a cluster centered on cardiac electrophysiology and calcium handling in heart muscle. The presence of terms related to skin, bone development, and brain region development are peripheral and may reflect broader developmental roles of the proteins, but the cardiac-related terms dominate the cluster.","confidence":"Medium","size":9,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0097050","count":2},{"id":"GO:1903244","count":2},{"id":"GO:0014808","count":2}]},{"hash":"2114195822622467856","title":"Chromatin Modification and Nucleosome Assembly","description":"This cluster is driven by terms related to nucleosome assembly and histone modification (H3-K27 methylation/acetylation, H3-K4 methylation), pointing to chromatin organization and epigenetic regulation of gene expression. Though some entries are obsolete and a couple terms touch on unrelated processes, the core signal is chromatin modification and nucleosome dynamics. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":1},{"id":"GO:0061087","count":1},{"id":"GO:2001040","count":1},{"id":"GO:1901674","count":1},{"id":"GO:1901536","count":1}]},{"hash":"450399812216533920","title":"Neuroimmune signaling and cytokine regulation","description":"These proteins are linked to cytokine production (IL-6 and IL-1\u03b2), eosinophil chemotaxis, and histamine response, while also showing neuromodulatory signaling via adrenergic and dopaminergic pathways that regulate adenylate cyclase and MAPK. The inclusion of saliva secretion points to autonomic/neuroendocrine control of secretory processes, tying together neural signals with immune/inflammatory responses and growth regulation. Overall, this cluster appears to represent a neuroimmune signaling module governing inflammation, secretion, and growth.","confidence":"Medium","size":9,"edges":32,"triangles":59,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032675","count":9},{"id":"GO:0046541","count":9},{"id":"GO:0008542","count":9},{"id":"GO:0071883","count":9},{"id":"GO:0034776","count":9}]},{"hash":"2033293116698077721","title":"Peroxisomal lipid metabolism and adipose development","description":"The cluster centers on lipid handling and energy-related processes: lipid hydroperoxide transport, cholesterol transport, ketone body biosynthesis, and adipose tissue development, with glyoxysome organization suggesting peroxisome involvement in fatty acid metabolism. While a couple terms are less related (response to hormone, isoleucine catabolic process), the core theme is peroxisome-driven lipid metabolism and adipose-related energy storage.","confidence":"Medium","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1902109","count":3},{"id":"GO:1901373","count":3},{"id":"GO:0010111","count":3},{"id":"GO:0009725","count":3},{"id":"GO:0006550","count":3}]},{"hash":"1186753857765012068","title":"Ciliary motility and microtubule transport","description":"The top GO terms are dominated by cilium-related activities (cilium movement, intraciliary retrograde transport, inner dynein arm assembly) and general microtubule-based movement (plus related neuronal transport), indicating a core theme around ciliary motility and microtubule motor transport. Some outliers (peroxisomal import, stress granule assembly) are less representative. Overall, the cluster likely reflects ciliary/motor transport functions.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003341","count":2},{"id":"GO:1990048","count":2},{"id":"GO:0016558","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0010765","count":2}]},{"hash":"1139491960101916125","title":"Golgi-ER Vesicle Trafficking and SNAREs","description":"The top GO terms cluster around vesicle transport between the ER and Golgi, intra-Golgi transport, ER-Golgi organization, and SNARE complex assembly, with additional hints of Golgi ribbon formation and related synaptic vesicle priming and receptor trafficking. This points to a cohesive function in SNARE-mediated Golgi-ER trafficking and Golgi architecture, with secondary links to synaptic vesicle dynamics.","confidence":"High","size":9,"edges":20,"triangles":17,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":6},{"id":"GO:0006891","count":6},{"id":"GO:0006888","count":6},{"id":"GO:0090161","count":6},{"id":"GO:0098967","count":5}]},{"hash":"688646645795771190","title":"Developmental signaling and morphogenesis","description":"The terms repeatedly point to developmental processes across tissues (bone, ear, skeletal muscle, neural plasticity) and include signaling (TGF-beta) and regulation of transcription, suggesting a cluster of proteins involved in development and tissue morphogenesis rather than a single, narrow function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0033234","count":2},{"id":"GO:0030916","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0014718","count":2}]},{"hash":"1474132114266629016","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by ribosome-related processes: translation, maturation of SSU rRNA, and ribosomal subunit biogenesis. Additional signals of RNA folding and regulation of translational fidelity suggest coordination between RNA processing and ribosome assembly, while the antibiotic response term reflects ribosome-targeted stress.","confidence":"High","size":9,"edges":31,"triangles":59,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000462","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0042274","count":2}]},{"hash":"756709428251264285","title":"Neuronal excitability and pain signaling","description":"Top GO terms cluster around electrical excitability and sensory signaling in excitable cells: membrane potential regulation, action potential generation, and ion transport via voltage-gated calcium and sodium channels; plus several pain-related and thermosensory responses, including cellular response to temperature, diet-induced thermogenesis, and detection of chemical stimuli involved in pain. This combination points to a cohesive theme of neuronal (and excitable-cell) signaling and nociception, with some thermosensory context.","confidence":"High","size":9,"edges":10,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0042391","count":4},{"id":"GO:0019228","count":4}]},{"hash":"1700049869081794185","title":"Endomembrane trafficking and GTPase signaling","description":"The cluster shows strong representation of endosome-lysosome and endosome-to-plasma membrane transport, lysosomal membrane organization, and exocytosis, all tied to small GTPase\u2013mediated signaling and regulation of GTPase activity. There are also cytoskeletal remodeling cues (actin/podosome) that support vesicle trafficking. A plant-specific term (floral organ abscission) appears as noise within this set but does not redefine the core endomembrane trafficking theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0030037","count":1},{"id":"GO:1902824","count":1},{"id":"GO:0071803","count":1},{"id":"GO:0045956","count":1}]},{"hash":"239711372619337161","title":"Calcium-dependent signaling and synaptic regulation","description":"The proteins show enrichment for calcium/calmodulin-dependent signaling: calcineurin-NFAT pathway, serine dephosphorylation, and regulation of postsynaptic calcium; terms for excitatory postsynaptic potential and cocaine response point to neuronal signaling, while cardiac hypertrophy in response to stress suggests calcium as a general stress signal. Together these suggest a cluster centered on Ca2+-driven signaling that modulates synaptic activity and related transcriptional and cellular responses.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0051533","count":3},{"id":"GO:0070940","count":3},{"id":"GO:0070262","count":2},{"id":"GO:0014898","count":2}]},{"hash":"274707335239575807","title":"Unknown","description":"The terms span neural development (anterior/posterior axis specification, forebrain regionalization) and diverse aspects of membrane biology and protein processing (myo-inositol transport, ER lumen retention, GPI anchor metabolism, protein-lipid remodeling). The lack of a single coherent biological theme across all terms makes it difficult to assign a specific, representative label for this cluster.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009948","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0006621","count":1},{"id":"GO:0034368","count":1},{"id":"GO:0021871","count":1}]},{"hash":"603196760675540833","title":"Diverse developmental processes","description":"The top GO terms span different tissues and species but all relate to development and differentiation, including ovarian follicle development, intestinal epithelial development, leg segmentation, and B cell differentiation, with a Notch signaling regulatory term also present. The distribution suggests the cluster captures a general developmental theme rather than a single specific function, so the label should reflect that breadth.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016267","count":1},{"id":"GO:0045747","count":1},{"id":"GO:0001541","count":1},{"id":"GO:0002315","count":1},{"id":"GO:0036011","count":1}]},{"hash":"160657887526884642","title":"Chromatin Regulation and Ciliogenesis","description":"The top GO terms point to nuclear and chromatin-related processes (chromatin organization, histone H3 acetylation, nuclear pore localization, protein ubiquitination), while others relate to ciliogenesis (cilium assembly) and retina development, with additional cues from cell cycle components (mitotic spindle assembly) and GTPase signaling. This suggests a theme centered on chromatin regulation with connected ciliary and cell-cycle functions, though the set is somewhat heterogeneous. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0070262","count":3},{"id":"GO:0043966","count":3}]},{"hash":"1243028363828775010","title":"Embryonic development, tissue homeostasis, and apoptosis","description":"The cluster prominently features developmental processes (retina and embryonic development, male gonad development) alongside tissue homeostasis (cell number in tissue, T cell homeostasis) and apoptotic pathways (neuron apoptotic process, ER-stress\u2013driven apoptotic signaling). There are also signals related to hypoxia response and kinase activity regulation, suggesting coordinated signaling control during development and maintenance. This combination points to a cohesive theme of development with regulated apoptosis and signaling rather than a single specific tissue function. ","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0071456","count":2}]},{"hash":"2179172018720729894","title":"Schwann cell-driven axon growth and regeneration","description":"The cluster highlights Schwann cell development, axon extension/regeneration, and sensory neuron fasciculation, along with receptor clustering and cell spreading\u2014together pointing to Schwann cell\u2013mediated axon guidance and nerve repair; ion transport and lipid signaling terms likely reflect supporting cellular signaling in this context.","confidence":"High","size":9,"edges":6,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010751","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0045773","count":4},{"id":"GO:0034446","count":4},{"id":"GO:0048680","count":4}]},{"hash":"1337831556410668491","title":"Ribosome biogenesis and rRNA processing","description":"Most top GO terms cluster around maturation of rRNA (SSU/LSU/5.8S from a tricistronic transcript), ribosomal large subunit biogenesis, and spliceosome-mediated mRNA processing, suggesting this cluster comprises proteins involved in ribosome assembly and RNA processing. Some terms like mitotic spindle assembly and ubiquitination appear less central, but the core signal points to ribosome biogenesis and RNA maturation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0042273","count":2}]},{"hash":"164907108638407076","title":"Regulators of cell proliferation, apoptosis, and migration","description":"This cluster is enriched for terms related to suppressing cell population growth (negative regulation of proliferation), promoting apoptosis, and enabling cell movement (cell migration), along with repression of the Wnt signaling pathway and various cell-cycle processes. The combination with transcription and dephosphorylation/GTPase regulation suggests coordinated signaling controls over growth, division, and motility, supporting a label focused on regulation of proliferation, apoptosis, and migration.","confidence":"High","size":9,"edges":7,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008285","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0090090","count":4},{"id":"GO:0043065","count":4},{"id":"GO:0000278","count":4}]},{"hash":"937320467391150221","title":"Cerebral cortex GABAergic interneuron development","description":"This cluster is dominated by brain-development terms, especially cerebral cortex GABAergic interneuron differentiation and fate commitment, with supporting forebrain patterning and midbrain development terms, indicating a neural-development focused group centered on cortical inhibitory interneurons. Some terms related to inner ear development, primitive streak formation, and cardiovascular morphogenesis may reflect broader embryonic patterning rather than core neural function.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0048839","count":7},{"id":"GO:0090009","count":5},{"id":"GO:0021892","count":5}]},{"hash":"678908752057266033","title":"Developmental signaling and tissue growth","description":"The top GO terms touch on developmental signaling (Notch receptor processing, neuronal stem cell maintenance, limb development) and tissue growth (cardiac muscle tissue growth) with supporting signals like prostaglandin biosynthesis and vitamin D response, plus general metabolism (CoA biosynthetic process). This pattern suggests a broad, multi-tissue developmental signaling theme rather than a single, cohesive pathway, so a label focusing on development and growth is most representative.","confidence":"Medium","size":9,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0071603","count":2},{"id":"GO:0015937","count":2},{"id":"GO:0090260","count":1}]},{"hash":"834176367911148788","title":"Brain development and patterning","description":"These proteins cluster around embryonic development with a focus on neural development: primitive streak formation, forebrain dorsal/ventral patterning, midbrain development, and cerebral cortex GABAergic interneuron differentiation and fate commitment. While a few terms pertain to other organs (thyroid gland and bronchiole morphogenesis, embryonic digestive tract morphogenesis), the recurrent emphasis on brain patterning and interneuron development suggests the core function is early neural specification and cerebral cortex formation. Therefore, this label captures the common theme of neural development driving the cluster.","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":4},{"id":"GO:0021892","count":4},{"id":"GO:0021798","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0048557","count":4}]},{"hash":"318458449362657515","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":28,"triangles":42,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":4},{"id":"GO:0071374","count":4},{"id":"GO:0071630","count":4},{"id":"GO:0006458","count":4},{"id":"GO:0036494","count":4}]},{"hash":"543192759620359101","title":"Neural development and behavior regulation","description":"This cluster is driven by brain-related terms: midbrain development, forebrain morphogenesis, axon target recognition, and adult walking and eating behavior, suggesting a focus on neural development and behavioral regulation. Regulatory processes like transcription control and MAP kinase activity further support signaling roles in neural contexts, while ubiquitin-dependent proteolysis/deubiquitination indicates protein turnover involvement. The presence of an outlier term (macrophage homeostasis) means the signal is not perfectly cohesive, so the label is a best-fit with Medium confidence. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0030901","count":1},{"id":"GO:0048853","count":1},{"id":"GO:0007412","count":1},{"id":"GO:0043407","count":1}]},{"hash":"1751715068971697009","title":"Cerebral Cortex GABAergic Interneuron Development","description":"The top GO terms cluster around neural development, especially differentiation and fate determination of cerebral cortex GABAergic interneurons, along with forebrain and midbrain patterning. While a couple of terms relate to unrelated metabolic or antimicrobial responses (likely annotation noise), the dominant signal points to brain development and interneuron specification, supporting the chosen name.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042208","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0090009","count":2}]},{"hash":"1984779445904853908","title":"RNA processing and translation machinery","description":"This cluster is dominated by GO terms related to RNA metabolism and protein synthesis, including mitochondrial translation, cytoplasmic translation, translational termination and its regulation, splicing complex assembly, and mRNA decay, indicating a shared function in RNA processing and translation control. Some tissue-differentiation terms appear, but the core signal ties to RNA processing and translation. ","confidence":"High","size":9,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":3},{"id":"GO:0006415","count":3},{"id":"GO:0035914","count":2},{"id":"GO:0000244","count":2},{"id":"GO:0006412","count":2}]},{"hash":"2279890353393621561","title":"Neuronal development and synaptic signaling","description":"The terms point to synaptic activity (excitatory postsynaptic potential), followed by signaling (ephrin receptor signaling) and cytoskeletal remodeling (actin branching/polymerization) essential for synapse formation, with substantia nigra development suggesting dopaminergic neuron lineage. Trafficking (ER-to-Golgi) and polarity (epithelial polarity establishment, tight junctions) appear as supporting cellular processes that also underpin neuronal polarization and compartmentalization, making a coherent neuronal development/synaptic theme. ","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0070830","count":2}]},{"hash":"974091010444374625","title":"Embryonic Eye and Vascular Development","description":"The terms show a strong emphasis on embryonic development with explicit eye-related terms (camera-type eye development, embryonic eye morphogenesis, amacrine cell differentiation) and vascular formation (lung vasculature development, venous blood vessel development, positive regulation of vascular wound healing). Additional terms like floor plate development and somitogenesis point to neural patterning in early development. Together, these suggest a cluster centered on early embryonic ocular and vascular morphogenesis.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0042981","count":5},{"id":"GO:0035881","count":4},{"id":"GO:0060426","count":4},{"id":"GO:0033504","count":4}]},{"hash":"1282725539874707301","title":"Golgi\u2013Endosome Transport Regulators","description":"This cluster is enriched for GO terms related to intracellular transport between endosomal compartments and the Golgi, including retrograde transport, late endosome to Golgi transport, and regulation of Rab signaling. While a few terms touch on lens morphogenesis or apoptotic signaling, the strongest recurring theme is vesicle trafficking and Rab-mediated routing, suggesting these proteins function as regulators of Golgi\u2013endosome trafficking and related signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070309","count":2},{"id":"GO:0042771","count":2},{"id":"GO:0032889","count":1},{"id":"GO:0045737","count":1},{"id":"GO:1902018","count":1}]},{"hash":"948651044840189924","title":"Multitissue Embryonic Development and Organogenesis","description":"The cluster is enriched for diverse developmental GO terms across multiple tissues (gonads, brain, placenta, hindlimb, eye, habenula, pituitary, heart outflow tract), plus a general transcriptional regulatory term. This pattern points to proteins involved in broad embryonic development and organogenesis rather than a single pathway, explaining the spread of organ-specific terms.","confidence":"High","size":9,"edges":11,"triangles":4,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":8},{"id":"GO:0007338","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0001890","count":7}]},{"hash":"2231492454117064620","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0016578","count":1},{"id":"GO:0043085","count":1},{"id":"GO:0007412","count":1},{"id":"GO:0045893","count":1}]},{"hash":"499481980427845566","title":"RNA Pol II transcription initiation and chromatin regulation","description":"The cluster includes GO terms related to RNA polymerase II preinitiation complex assembly, regulation of transcription elongation by RNAP II, transcription antitermination, and histone modification regulation, pointing to a common theme of transcription control and chromatin state. A few terms (cilium movement, gas vesicle organization, ribosomal subunit assembly) appear unrelated, suggesting annotation noise; overall, the core theme is transcriptional regulation with chromatin context.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":1},{"id":"GO:0003341","count":1},{"id":"GO:0031412","count":1},{"id":"GO:1990048","count":1},{"id":"GO:0051123","count":1}]},{"hash":"575245836439814149","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"These proteins collectively point to neural signaling and sensory processing: pain perception, temperature response, and visual perception/learning, alongside dopaminergic synaptic transmission and behavioral responses to cocaine, which together suggest neuromodulatory pathways and reward-related signaling. The sodium import term aligns with neuronal excitability. A few terms like aerotaxis and diet-induced thermogenesis are less directly tied to neural signaling but may reflect broader energy-sensing or cell signaling contexts. Overall, the cluster seems to group neural sensory processing and dopamine-driven signaling.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0071502","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0008542","count":3},{"id":"GO:0098719","count":3}]},{"hash":"1764826815191039042","title":"Unknown","description":"The top GO terms span diverse developmental processes across tissues (fat cell, retinal pigment epithelium, tracheal cartilage, lymphatic endothelial fate) as well as RNA processing, with no single coherent function tying the cluster together; thus a specific, representative label isn\u2019t justified.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0003406","count":1},{"id":"GO:0060164","count":1}]},{"hash":"561407897600449314","title":"Neural retina transport and signaling","description":"The top GO terms point to neural/retina-related functions (retina development, neurotransmitter loading into synaptic vesicles) and various membrane transport processes (potassium ion transport, vitamin and dehydroascorbic acid transport) alongside sugar-related responses (glucose/fructose stimuli, lactose biosynthesis) and osmotic stress. This pattern suggests a cluster of proteins involved in neural retinal physiology with membrane transport and metabolic/osmotic signaling roles. Confidence: Medium","confidence":"","size":9,"edges":8,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0042149","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0042891","count":1},{"id":"GO:0070837","count":1}]},{"hash":"354760087016808534","title":"Glycolysis and gluconeogenesis core metabolism","description":"This cluster is dominated by carbohydrate metabolism signals, with core glycolysis (GO:0061621) and gluconeogenesis (GO:0006094) terms, plus related fructose and carbohydrate catabolic processes, suggesting a group of enzymes involved in energy-yielding metabolism. An outlier term for pituitary gland development likely reflects broader or pleiotropic annotations rather than a true functional theme. Overall, the cluster aligns with carbohydrate metabolism, especially glycolysis and gluconeogenesis.","confidence":"High","size":9,"edges":12,"triangles":6,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0061621","count":3},{"id":"GO:0006094","count":3},{"id":"GO:0042853","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0030388","count":2}]},{"hash":"2064050006594803429","title":"Mitotic Entry and Cell Cycle Regulation","description":"The cluster is dominated by terms related to initiating and controlling cell division, including G1/S transition, positive regulation of CDK activity, and re-entry into mitosis, along with chromosome condensation concepts. While there are ancillary terms linked to tissue-specific proliferation (skeletal muscle development, liver regeneration) and stress responses (ER unfolded protein response), the strongest and most frequent signals point to mitotic entry and cell-cycle control. Some annotations (e.g., brassinosteroid signaling) may reflect cross-species annotations and are less central to this cluster\u2019s core function.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000082","count":4},{"id":"GO:0048741","count":3},{"id":"GO:0009742","count":3},{"id":"GO:1903251","count":2},{"id":"GO:0044321","count":2}]},{"hash":"328733970227542956","title":"Chloroplast transcription and iron/tetrapyrrole metabolism","description":"The top GO terms show a clear emphasis on transcriptional regulation (DNA-templated transcription and positive regulation of transcription by RNA polymerase II) alongside chloroplast-related processes (photosynthesis, regulation of tetrapyrrole metabolism) and iron handling (iron ion transport, detoxification of iron, siderophore-iron import). This points to a theme where transcriptional control intersects with iron-dependent chloroplast functions, such as chlorophyll/tetrapyrrole biosynthesis and photosynthetic apparatus assembly. Some terms are obsolete, and the cluster appears functionally cohesive around chloroplast iron metabolism and transcriptional regulation, but with some heterogeneity.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0045944","count":2},{"id":"GO:1904234","count":1},{"id":"GO:0097286","count":1},{"id":"GO:1990461","count":1}]},{"hash":"1467654291496430543","title":"Immune and extracellular remodeling proteins","description":"This cluster is dominated by GO terms related to immune activity (complement activation, adaptive immune response) and extracellular remodeling processes (positive regulation of exocytosis, plasminogen activation, proteoglycan biosynthesis), suggesting secreted or matrix-modifying roles. The presence of triglyceride homeostasis and leptin response hints at metabolic context, but the strongest signal is immune and extracellular proteolysis/ECM remodeling, which justifies a label centered on immune and ECM-related functions.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0045921","count":4},{"id":"GO:0030210","count":3},{"id":"GO:0031639","count":3},{"id":"GO:0051005","count":3}]},{"hash":"2072064479753311120","title":"Cofactor and fatty acid biosynthesis cluster","description":"The top GO terms show a strong emphasis on biosynthetic processes: protoporphyrinogen IX (heme) biosynthesis, biotin biosynthesis, menaquinone biosynthesis, fatty acid biosynthesis and related acyl-CoA metabolism, plus related redox processes. This suggests a cluster of proteins involved across multiple biosynthetic pathways rather than a single pathway, with fatty acid and cofactor (porphyrin/biotin/menaquinone) production as the unifying theme. The seed coat development term is plant-specific and less directly connected, but does not outweigh the predominant biosynthetic pattern. ","confidence":"Medium","size":9,"edges":33,"triangles":63,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0019878","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0055114","count":2}]},{"hash":"386242485229836","title":"Angiogenesis and Endothelial Signaling","description":"Top GO terms show strong enrichment for angiogenesis and endothelial cell migration, including positive regulation of canonical Wnt signaling, suggesting a vascular development and endothelial signaling theme. Additional terms like phosphatidylinositol dephosphorylation and caveolin-mediated endocytosis point to lipid signaling and vesicular regulation of these pathways. Some terms appear peripheral (e.g., DNA transposition), but the dominant signal centers on angiogenic processes in blood vessels.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0043536","count":2}]},{"hash":"1397447375571903627","title":"Neuronal adhesion, guidance, and synapse assembly","description":"The cluster centers on neural connectivity: cell adhesion (homophilic/heterophilic), axon guidance via Robo signaling, synapse assembly, and neuron migration, with related planar polarity and axon localization terms, plus a grooming-behavior association. These collectively point to roles in establishing neural circuits and connectivity.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0021836","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0035385","count":3}]},{"hash":"1984294119241522814","title":"Cell Cycle and Transcription Regulation","description":"The strongest signals are cell-cycle related: spindle assembly and centrosome cycle, pointing to microtubule- and centrosome-associated processes. There are also transcription-related GO terms (RNA polymerase II initiation and regulation), suggesting a secondary theme around transcription control. The mix of cell division and transcription terms indicates a broad functional set, with weaker ties to other processes like differentiation and development; thus a concise label capturing both primary themes is \"Cell Cycle and Transcription Regulation.\"","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0007098","count":2},{"id":"GO:0006367","count":1},{"id":"GO:0042795","count":1},{"id":"GO:0006355","count":1}]},{"hash":"2045825238219846805","title":"Unknown","description":"This cluster shows no single shared function: GO terms span redox homeostasis, RNA stability regulation, DNA repair, signaling, development, aging, and metabolism, among others. The terms describe diverse biological processes rather than a cohesive pathway, making a concise, specific label inappropriate.","confidence":"","size":9,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":7},{"id":"GO:0014912","count":7},{"id":"GO:0003335","count":7},{"id":"GO:0007568","count":7},{"id":"GO:0043488","count":7}]},{"hash":"11373185999296606","title":"GABAergic Synapses and Sensory Processing","description":"Top terms point to inhibitory neurotransmission (GABA receptor clustering, inhibitory postsynaptic potential, negative regulation of transmission of nerve impulse) and sensory processing (sound perception), with supporting links to neural development and drug responses (nicotine, cocaine). This suggests a cohesive cluster centered on GABAergic synapses and neural signaling involved in sensory function.","confidence":"High","size":9,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1905906","count":7},{"id":"GO:0021631","count":7},{"id":"GO:0060080","count":7},{"id":"GO:0035094","count":7},{"id":"GO:0097112","count":7}]},{"hash":"330475602383711871","title":"Developmental ECM remodeling and cell adhesion","description":"The top GO terms point to bone development (osteoblast differentiation, bone trabecula formation) alongside extracellular matrix disassembly and cell\u2013cell adhesion (homophilic/heterophilic), and even planar polarity and various tissue development terms (forebrain, hair follicle, muscle satellite cells). This suggests a theme of ECM remodeling and cell adhesion guiding morphogenesis across multiple tissues rather than a single tissue-specific process. ","confidence":"Medium","size":9,"edges":13,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045669","count":3},{"id":"GO:0060346","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1925333979553168308","title":"Lamellipodium assembly and neutrophil migration","description":"The cluster shows strong representation for lamellipodium assembly and neutrophil chemotaxis, indicating a shared involvement in actin cytoskeleton remodeling and directional cell movement. Other terms are more diverse (transcription initiation, DNA transposition, stem cell maintenance, signaling pathways, adhesion, microtubule anchoring) and may reflect background annotations, but the dominant theme is motility.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0030593","count":2},{"id":"GO:0006367","count":1},{"id":"GO:0006313","count":1}]},{"hash":"47660272614226995","title":"Cardiovascular development and skeletal differentiation","description":"This cluster shows strong signals for heart and vascular development (endothelial adhesion, VEGF signaling, sprouting angiogenesis, ventricular septum and valve morphogenesis, integrin-mediated adhesion) and also skeletal formation processes (cartilage condensation, osteoblast differentiation), implying a shared mesenchymal program that influences both cardiac vasculature and skeletal tissues.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071603","count":2},{"id":"GO:0003281","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0045669","count":2},{"id":"GO:0031659","count":2}]},{"hash":"68479728503042637","title":"Embryonic organ differentiation and morphogenesis","description":"The top GO terms point to tissue and organ differentiation across multiple systems (endocardial, tracheal cartilage, mesenchymal, respiratory, digestive tract, and glial development). This suggests a broad developmental/morphogenetic theme rather than a single pathway, with a couple of outliers (immune signaling and apoptosis regulation) that do not override the overall pattern.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046533","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0060956","count":2},{"id":"GO:2000741","count":2},{"id":"GO:0003016","count":2}]},{"hash":"1229886758214557361","title":"ECM Remodeling and Metabolic Signaling","description":"The top GO terms cluster around extracellular matrix interactions (cell-matrix adhesion, proteoglycan biosynthesis) and remodeling (plasminogen activation), coupled with metabolic signals (lipoprotein lipase regulation, triglyceride homeostasis, leptin response) and muscle-related processes (satellite cell proliferation), with minor immune and platelet regulation\u2014together suggesting a tissue remodeling context where ECM dynamics intersect metabolic and signaling pathways.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0030210","count":1},{"id":"GO:0031639","count":1},{"id":"GO:0051005","count":1},{"id":"GO:0070328","count":1}]},{"hash":"199475228379423921","title":"Rho-Driven Cytoskeletal Remodeling","description":"The GO terms cluster around actin cytoskeleton dynamics, including Rho GTPase activation, Rho signaling, lamellipodium and stress fiber assembly, and cell spreading, along with related processes like spindle assembly and morphogenesis. This suggests a set of proteins coordinating cytoskeletal remodeling, adhesion, and migration, with broader roles in development-related morphogenesis. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":3},{"id":"GO:0060124","count":2},{"id":"GO:0060313","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0090307","count":2}]},{"hash":"771584671660243730","title":"Unknown","description":"The top GO terms span very diverse processes (redox homeostasis, aging, skin/corneocyte development, lipid signaling, RNA stability, DNA repair/recombination, and glycogen regulation) with no clear, unifying function across the proteins, so a single representative label is not evident.","confidence":"","size":8,"edges":7,"triangles":2,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0014912","count":3},{"id":"GO:0003335","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0046856","count":3}]},{"hash":"301365673565224295","title":"RNA processing and chromatin dynamics","description":"This cluster centers on RNA metabolism\u2014P-body assembly, tRNA processing, mRNA decapping, and spliceosomal assembly\u2014alongside chromatin-related processes such as pericentric heterochromatin formation and histone mRNA metabolism. The presence of stress-related and cell-cycle terms (response to water deprivation, abscisic acid, negative regulation of G0 to G1) suggests a coordinated program linking RNA processing with chromatin regulation during stress and growth transitions. Confidence: Medium","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0033962","count":8},{"id":"GO:0009414","count":7},{"id":"GO:0008033","count":7},{"id":"GO:1990141","count":7},{"id":"GO:0008334","count":7}]},{"hash":"900982994912985427","title":"mRNA processing and translation initiation","description":"This cluster is enriched with GO terms tying together mRNA maturation (spliceosome-mediated splicing and alternative splicing) and translation initiation processes (preinitiation complex formation, reinitiation, and IRES-dependent initiation). The presence of terms for splicing and for eIF4F complex assembly suggests proteins involved in both mRNA processing and the control of translation, possibly linking stress-responsive regulation of mRNA stability to initiation. Overall, the set appears to reflect a module at the intersection of mRNA maturation and initiation of protein synthesis.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0000380","count":4},{"id":"GO:0010610","count":4},{"id":"GO:0000398","count":3}]},{"hash":"1998605249895778281","title":"RNA processing and translational regulation","description":"This cluster centers on RNA metabolism and control of translation, with emphasis on translation initiation (eIF4F complex) and IRES-dependent initiation, plus associated mRNA processing steps (splicing, poly(A) tail regulation, export). These shared functions suggest the proteins work together in RNA processing and regulation of protein synthesis.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0097010","count":3},{"id":"GO:1902625","count":3},{"id":"GO:0075522","count":3},{"id":"GO:1903586","count":3},{"id":"GO:0060211","count":3}]},{"hash":"2199525539082712273","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":10,"triangles":6,"max_degree":5,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0042766","count":2},{"id":"GO:0016584","count":2},{"id":"GO:0048568","count":2}]},{"hash":"1637459285267838029","title":"Developmental Signaling and Cytoskeletal Regulation","description":"This cluster centers on positive regulation of phosphorylation (peptidyl-threonine/tyrosine), which points to signaling roles, alongside Arp2/3-mediated actin nucleation, supporting cytoskeletal dynamics. Coupled with GO terms for mitotic cell cycle and various developmental processes (skin, retinal cone cells, multicellular organism development) and mRNA transport, the proteins together imply a role in signaling-driven development and cellular organization. Hence a label around developmental signaling with cytoskeletal regulation captures the shared theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010800","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0035690","count":2}]},{"hash":"1126172977923549130","title":"Epigenetic Regulation in Early Development","description":"The cluster shows enrichment for embryogenesis-related processes (embryonic placenta morphogenesis, blastocyst formation) alongside chromatin and epigenetic regulation (nucleosome assembly, histone H3K27 methylation regulation). This suggests a common theme where chromatin remodeling and epigenetic marks guide early developmental programs, despite a few peripheral or obsolete terms present. ","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045869","count":3},{"id":"GO:1901536","count":3},{"id":"GO:0060669","count":3},{"id":"GO:0001825","count":2},{"id":"GO:0006334","count":2}]},{"hash":"1804940179078730816","title":"Transcription and ribosome biogenesis","description":"Dominant themes are transcription (DNA-templated) and ribosome biogenesis/translation, plus ribosomal subunit assembly and SRP-dependent cotranslational targeting to membranes, with chromatin modification terms also present. This points to a cluster of proteins involved in gene expression regulation and the protein synthesis machinery. The IL-4 response is minor, and overall the signal centers on transcription and ribosome-related processes.","confidence":"High","size":8,"edges":10,"triangles":4,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0034729","count":2},{"id":"GO:0006349","count":2}]},{"hash":"327918634699526368","title":"Microtubule-driven transport and spindle dynamics","description":"Top GO terms cluster around movement and transport along microtubules and around mitotic spindle dynamics: anterograde dendritic transport, plus-end\u2013directed vesicle transport, spindle assembly/elongation, spindle midzone formation, and nuclear migration along microtubules. A neuronal structure term (Purkinje cell layer organization) hints at specialized cytoskeletal roles in neurons, while chloroplast movement is a plant-related process also relying on microtubules. Overall, the shared theme is microtubule-based transport and spindle/mitotic organization across cell types.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098971","count":7},{"id":"GO:0009904","count":7},{"id":"GO:0090307","count":7},{"id":"GO:0072383","count":7},{"id":"GO:0051255","count":7}]},{"hash":"2121203676633799218","title":"Cross-tissue Regulation of Transcription and Signaling","description":"The top GO terms point to broad regulatory roles (regulation of cytokinesis, GTPase activity, transcription by RNA Pol II, calcium signaling at synapses, muscle dynamics, and developmental processes across lung, kidney, and visual systems), suggesting a cluster of proteins involved in general regulation rather than a single pathway, across multiple tissues.","confidence":"Medium","size":8,"edges":5,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032465","count":8},{"id":"GO:0060487","count":8},{"id":"GO:0043547","count":7},{"id":"GO:0045944","count":6},{"id":"GO:0032972","count":4}]},{"hash":"1331487885451299791","title":"Microtubule-based transport and spindle dynamics","description":"Most top GO terms describe microtubule-dependent transport (anterograde dendritic transport of receptor complexes, plus-end-directed vesicle transport) and mitotic spindle activities (assembly, elongation, spindle midzone, nuclear migration along microtubules). The Purkinje cell layer organization term reflects neuronal cytoskeletal architecture, and the chloroplast movement term aligns with cytoskeletal cargo transport; together they indicate a cluster of proteins involved in microtubule dynamics and cargo movement in both mitotic and neuronal contexts.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098971","count":8},{"id":"GO:0009904","count":8},{"id":"GO:0090307","count":8},{"id":"GO:0072383","count":8},{"id":"GO:0051255","count":8}]},{"hash":"1490001850153393154","title":"Developmental Signaling and Adhesion Regulators","description":"The GO terms cluster around modulation of major developmental signaling pathways (notably negative regulation of TGF-beta receptor signaling and BMP signaling) and cell adhesion (homophilic cell-cell adhesion, endothelial adhesion). Additional terms point to neural development and synapse assembly, suggesting roles in nervous system maturation and tissue organization during development. A few terms (genital morphogenesis, antigen processing) are more divergent, but do not alter the core theme. Confidence: Medium","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030512","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0035260","count":1},{"id":"GO:0071205","count":1},{"id":"GO:0060117","count":1}]},{"hash":"1686355520339519763","title":"Mitotic Chromosome Organization and Spindle Assembly","description":"This cluster is best described as mitosis-related chromatin dynamics and spindle assembly. It is enriched for mitotic cell cycle, cell division, chromatin organization, and spindle assembly terms, with supporting hints from histone modification and ubiquitination. The additional terms (nuclear pore localization and Golgi-to-ER transport) may reflect broader cellular reorganization during division.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0070262","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0060271","count":2}]},{"hash":"2254944207742466657","title":"Neural Development and Synaptic Signaling","description":"This cluster is dominated by neural-related terms: excitatory postsynaptic potential, visual perception, axonogenesis, and long-term synaptic potentiation point to neuronal development and synaptic function. While other terms (mitotic cell cycle, angiogenesis, myoblast fusion, ABA signaling) appear, they seem ancillary to the main neural-focused theme. Hence the label reflects the core function of the group with moderate confidence due to some non-neural terms in the mix.","confidence":"Medium","size":8,"edges":11,"triangles":6,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0010800","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0009738","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1925268739569959665","title":"Developmental transcription and signaling","description":"The cluster's GO terms center on regulation of gene expression and signaling in development: DNA-templated transcription, mRNA transport, and signaling pathways such as NF-kappaB and actin nucleation, plus development-related terms like skin development and multicellular organism development. Hormonal responses (glucocorticoid, cAMP) further support regulation during development and tissue differentiation. While broad, the recurring theme is how transcription and signaling coordinate developmental outcomes. ","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0050731","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0051591","count":2},{"id":"GO:0051028","count":2}]},{"hash":"410808713408953437","title":"Embryonic organogenesis and morphogenesis","description":"The GO terms point to broad developmental roles across multiple organs (ureteric bud morphogenesis, embryonic digestive tract morphogenesis, neural crest migration, nephron tubule formation, lacrimal and pituitary gland development, pancreas and skeletal muscle differentiation) with accompanying transcriptional regulation, suggesting a cluster of proteins involved in embryonic organ development and tissue morphogenesis.","confidence":"High","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090190","count":6},{"id":"GO:0048557","count":5},{"id":"GO:0001755","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0031018","count":5}]},{"hash":"1181461763377487007","title":"Neurodevelopment and Brain Morphogenesis","description":"The cluster is dominated by neural development terms: brain development, forebrain patterning, midbrain development, and GABAergic interneuron differentiation, plus inner ear development and broader embryonic morphogenesis. A few terms point to transcriptional regulation during development, suggesting regulatory factors guiding neurodevelopment. Overall, these proteins appear to participate in neural patterning and brain morphogenesis, with some related embryonic development processes.","confidence":"High","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0048839","count":3},{"id":"GO:0060303","count":2}]},{"hash":"750843494942086802","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0006397","count":2}]},{"hash":"330158093753379258","title":"Embryonic organ and tissue development","description":"This cluster is dominated by GO terms describing development of multiple organs and tissues (mammary gland, spinal cord, placenta, retina vasculature, digestive tract, uterus, etc.), pointing to a shared theme of embryonic organogenesis and tissue differentiation. Prostaglandin biosynthesis may support developmental signaling, while the camphor catabolic term appears incidental. Overall, the grouping reflects broad developmental programs rather than a single pathway.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007548","count":3},{"id":"GO:0030879","count":3},{"id":"GO:0021510","count":2},{"id":"GO:0001892","count":2},{"id":"GO:0061298","count":2}]},{"hash":"978647205351493220","title":"Unknown","description":"GO terms span hair cycle and body patterning, angiogenesis, kidney and neural development, immune differentiation, synapse and hearing development, and lipid signaling, with no single unifying function.","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045317","count":3},{"id":"GO:0048105","count":3},{"id":"GO:0001955","count":3},{"id":"GO:0051796","count":3},{"id":"GO:0002315","count":3}]},{"hash":"1640428358193016219","title":"DNA replication and cell division with angiogenesis","description":"This cluster centers on core DNA replication and cell cycle processes (cell division, DNA replication, telomere maintenance, replication fork reversal) indicating proliferative, genome-maintaining activity. In addition, GO terms related to angiogenesis and endothelial cell migration suggest a vascular development or endothelial-proliferation context. Some obsolete terms add noise, but the dominant theme links DNA replication/cell division with angiogenic signaling.","confidence":"Medium","size":8,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0043536","count":2}]},{"hash":"1944409433619827741","title":"Neuronal vesicle trafficking and synaptic transport","description":"The top GO terms cluster around intracellular trafficking of vesicles in the secretory pathway (ER\u2013Golgi, Golgi\u2013ER, Golgi to vacuole, endosome to melanosome) and synaptic vesicle cycling (anterograde transport, endocytosis), with brain-specific hints (Purkinje cell maturation, cocaine response). This points to a cohesive theme of neuronal vesicle transport and synaptic vesicle dynamics.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0006890","count":1},{"id":"GO:0006896","count":1}]},{"hash":"1506981716432521975","title":"TNF-NF-kB immune signaling and ubiquitination","description":"This cluster\u2019s top GO terms cluster around TNF-mediated signaling, NF-kB activation, and K48-linked ubiquitination, pointing to immune signaling and ubiquitin-proteasome\u2013mediated regulation as a core theme. Although a few terms touch on peroxisome import and chromatin/dosage regulation, the dominant pattern is immune-related signaling and protein modification, justifying a label reflecting immune signaling with ubiquitination.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901253","count":7},{"id":"GO:0033209","count":7},{"id":"GO:1903762","count":7},{"id":"GO:1900095","count":7},{"id":"GO:0070936","count":7}]},{"hash":"1778459948660043543","title":"Translational Regulation and mRNA Processing","description":"The top GO terms point to control of translation initiation (eIF4F assembly, regulation of translation initiation, IRES-dependent translation) alongside post-transcriptional mRNA processing and export (splicing, poly(A) tail regulation, nuclear export) and miRNA-mediated translational silencing. This suggests a cluster of proteins involved in coordinating when mRNAs are translated and how they are processed and exported, rather than a single enzymatic activity.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097010","count":2},{"id":"GO:1902625","count":2},{"id":"GO:0075522","count":2},{"id":"GO:1903586","count":2},{"id":"GO:0060211","count":2}]},{"hash":"224037551904480687","title":"Embryonic development and organ morphogenesis","description":"The Top Terms include multicellular organism development and a mix of neural-specific terms (forebrain patterning, cerebral cortex GABAergic interneuron differentiation/fate commitment, midbrain development) along with morphogenesis of other organs (bronchiole development, digestive tract morphogenesis, vascular morphogenesis, primitive streak formation). This points to a broad embryonic development program shaping multiple tissues, with emphasis on neural differentiation. ","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0090009","count":2},{"id":"GO:0021892","count":2},{"id":"GO:0021798","count":2},{"id":"GO:0030901","count":2}]},{"hash":"1082560198837863092","title":"GPCR-Mediated Cytokine Signaling","description":"Top GO terms indicate regulation of cytokine production (IL-6, IL-1\u03b2) and eosinophil chemotaxis, pointing to immune/inflammatory activity. The presence of GPCR-related signaling terms (dopamine/adrenergic receptor pathways, adenylate cyclase activation/inhibition) suggests a module where GPCR activity influences cytokine responses and immune cell recruitment. Some terms like saliva secretion and visual learning are less directly related and may reflect annotation noise, but do not override the dominant GPCR-immune theme. This leads to a concise label focusing on GPCR-driven immune signaling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032675","count":2},{"id":"GO:0046541","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0071883","count":2},{"id":"GO:0034776","count":2}]},{"hash":"2159497742175224638","title":"Golgi trafficking and sorting","description":"This cluster is dominated by GO terms related to the Golgi apparatus and intracellular transport, including Golgi ribbon formation, various Golgi- and endosome-to-Golgi transport processes, protein localization to the Golgi, and Golgi-to-plasma membrane traffic, as well as microtubule anchoring which helps position the Golgi. These collectively point to a shared role in Golgi maintenance and cargo sorting within the secretory pathway. Some terms (like mating behavior and axon extension) appear peripheral to this core theme, likely reflecting broader functional annotations rather than a primary cluster driver.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":1},{"id":"GO:0034453","count":1},{"id":"GO:0048047","count":1},{"id":"GO:0034499","count":1},{"id":"GO:0006622","count":1}]},{"hash":"27977359269143153","title":"Drosophila embryonic morphogenesis and epithelial polarity","description":"The top GO terms cluster around developmental morphogenesis and tissue organization\u2014especially epithelial polarity (follicular epithelium), imaginal disc\u2013derived wing vein specification, and broader embryonic development (gastrulation, nerve maturation, synaptic regulation). This pattern strongly points to a Drosophila developmental program governing morphogenesis and epithelial remodeling.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021682","count":1},{"id":"GO:0010470","count":1},{"id":"GO:1903798","count":1},{"id":"GO:0007016","count":1},{"id":"GO:0060441","count":1}]},{"hash":"977609836650512317","title":"RNA processing and translational control in neurons","description":"The GO terms are dominated by RNA maturation and post-transcriptional regulation (mRNA capping, regulation of translational initiation, primary miRNA processing, siRNA processing, miRNA-mediated silencing, histone mRNA metabolism, and pre-mRNA processing), with one neuronal synapse\u2013related term (neuroligin clustering) suggesting a neuronal context. This points to a cluster centered on RNA processing and control of translation, likely in neurons.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097118","count":2},{"id":"GO:1905612","count":1},{"id":"GO:1905618","count":1},{"id":"GO:0006370","count":1},{"id":"GO:0008315","count":1}]},{"hash":"1453915587511702392","title":"Unknown","description":"The GO terms are scattered across unrelated processes: redox homeostasis, regulation of mRNA stability, DNA repair, corneocyte development, cell migration, glycogen synthase regulation, PI dephosphorylation, and even an obsolete aging term or cross-species hemolysis. There is no cohesive functional theme that ties the proteins together, and no dominant pathway or molecular function emerges from the Top Terms. Therefore a concise, representative label cannot be assigned.","confidence":"","size":8,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045454","count":4},{"id":"GO:0014912","count":4},{"id":"GO:0003335","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0043488","count":4}]},{"hash":"1145870725359551744","title":"Embryonic morphogenesis and growth regulation","description":"Many terms cluster around embryonic development (forebrain development, embryonic cranial skeleton morphogenesis), regulation of proliferation and apoptosis (negative regulation of cell population proliferation, apoptotic process, positive regulation of apoptotic process), and key growth-signaling pathways (Wnt, Hippo). The combination suggests proteins involved in developmental morphogenesis and growth control during embryogenesis.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008285","count":7},{"id":"GO:0016477","count":7},{"id":"GO:0090090","count":7},{"id":"GO:0043065","count":7},{"id":"GO:0060044","count":7}]},{"hash":"2093880259471452295","title":"Unknown","description":"The top GO terms are highly diverse, spanning immune cell death, germ cell development, endocytosis, small GTPase signaling, myelin maintenance, insulin signaling, and cytokine responses. There is no clear, single functional theme tying the proteins together, suggesting either multi-functionality or heterogeneous annotations. ","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006924","count":2},{"id":"GO:0007281","count":1},{"id":"GO:0072583","count":1},{"id":"GO:0007264","count":1},{"id":"GO:0032287","count":1}]},{"hash":"105738440516661068","title":"Unknown","description":"The GO terms span neural signaling (visual learning, excitatory postsynaptic potential, response to cocaine) as well as metabolic and developmental processes (glucose metabolism, insulin signaling, thyroid gland development), with some terms not clearly related. There isn\u2019t a single cohesive function that ties these proteins together, so a concise, unified label is not justifiable. ","confidence":"","size":8,"edges":25,"triangles":41,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":8},{"id":"GO:0047484","count":8},{"id":"GO:0060079","count":8},{"id":"GO:0042220","count":8},{"id":"GO:0060258","count":8}]},{"hash":"1827734969184338044","title":"Neuroendocrine Signaling and Learning","description":"The GO terms point to a mix of neural activity (excitatory postsynaptic potential, visual learning, cocaine response), immune signaling (LPS-mediated signaling, TNF production), and endocrine pathways (insulin receptor signaling, thyroid gland development), suggesting cross-talk among nervous, immune, and endocrine signaling that could influence learning and homeostasis.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031663","count":7},{"id":"GO:0042535","count":7},{"id":"GO:0008542","count":6},{"id":"GO:0047484","count":6},{"id":"GO:0008285","count":6}]},{"hash":"852295386367639326","title":"Endothelial Angiogenesis and Inflammatory Regulation","description":"This cluster centers on endothelial cell functions involved in new blood vessel formation and signaling, including sprouting angiogenesis, endothelial migration, and integrin signaling, alongside regulation of inflammatory cytokines (both pro- and anti-inflammatory). The presence of receptor-mediated endocytosis and lipoprotein clearance terms further supports a vascular/endothelial context where proteolytic processing and hormonal regulation may also occur. Taken together, the dominant theme is endothelial signaling governing angiogenesis with immune-modulatory activity.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":2},{"id":"GO:0002040","count":1},{"id":"GO:0031638","count":1},{"id":"GO:0034381","count":1},{"id":"GO:0043542","count":1}]},{"hash":"1928834485569442616","title":"Signaling for Cell Shape and Polarity","description":"The top GO terms point to multiple signaling pathways (thrombin receptor signaling, Wnt, angiotensin/PLC) and regulation of Rho signaling, all converging on cytoskeletal dynamics, cell adhesion/spreading, and establishing or maintaining cell polarity. This suggests a cohesive theme of signaling networks that govern cell morphology and movement, even though a few terms (DNA transposition, muscle atrophy, lactate metabolism) are less connected and may reflect incidental annotations. Confidence: Medium","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070493","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0048549","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0006313","count":1}]},{"hash":"440554527811498817","title":"Transmembrane Transport of Ions and Metabolites","description":"The GO terms show multiple transmembrane transport activities for sulfate, chloride, fructose, aspartate, oxalate, and bicarbonate, plus related pH changes, suggesting a core function in moving small molecules and ions across membranes. Some unrelated terms (sperm capacitation, sensory perception of sound) appear but do not define the cluster; overall the cohesion is membrane transport.","confidence":"Medium","size":8,"edges":18,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1902358","count":1},{"id":"GO:0048240","count":1},{"id":"GO:1902476","count":1},{"id":"GO:0015755","count":1},{"id":"GO:0051454","count":1}]},{"hash":"1921481682319993604","title":"Neuronal and Cardiac Excitability Signaling","description":"The cluster's GO terms cluster around electrical signaling and ion-channel activity, including neuronal action potential, calcium and sodium ion transport, and membrane depolarization in Purkinje myocytes, indicating ion-channel\u2013driven excitability in neurons and cardiac tissue. Additional signals like cGMP response and Rho pathway regulation support broader signaling network involvement. Some terms (skin development, pancreatic cell apoptosis, pain detection) are less directly connected and may reflect annotation breadth, but the dominant theme is excitability and ion transport.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035024","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0019228","count":2},{"id":"GO:0061577","count":2},{"id":"GO:0086047","count":2}]},{"hash":"864309344526798592","title":"Meiotic Chromosome Organization and DNA Repair","description":"The top GO terms emphasize meiotic processes and chromatin dynamics, notably synaptonemal complex organization, double-strand break repair via homologous recombination, and chromatin regulation. These point to proteins involved in meiotic chromosome pairing and DNA repair, with supporting signals from chromatin remodeling and spindle-related terms, suggesting a cohesive role in meiosis and chromosome maintenance rather than general metabolism. The embryonic development term is broader but does not override the stronger meiosis/chromatin signals.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070193","count":8},{"id":"GO:0070459","count":8},{"id":"GO:0010620","count":8},{"id":"GO:0031497","count":8},{"id":"GO:0051569","count":8}]},{"hash":"197532848401311988","title":"Neural development and calcium signaling","description":"The top GO terms are centered on neural development and brain-related functions (negative regulation of neuron differentiation, visual learning, neuromuscular balance, norepinephrine response) along with calcium handling (regulation of calcium ion import, ER calcium homeostasis). Although there\u2019s some vascular/ECM context, the dominant theme appears to be neural differentiation/signaling and associated calcium dynamics, suggesting a neural development\u2013calcium signaling cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045665","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0030198","count":1},{"id":"GO:1905949","count":1},{"id":"GO:0051563","count":1}]},{"hash":"960526438312176937","title":"Golgi- and endosome-lysosome vesicle trafficking","description":"The GO terms cluster around Golgi localization and a suite of vesicle trafficking steps: Golgi-to-plasma membrane transport, ER-to-Golgi transport, endosome-to-lysosome/vacuole trafficking, and lysosomal membrane organization, all with regulation by small GTPases and exocytosis cues. This points to a cohesive module governing Golgi- and endosome/lysosome\u2013associated vesicle trafficking and membrane traffic.","confidence":"High","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000042","count":4},{"id":"GO:0043001","count":4},{"id":"GO:1902824","count":3},{"id":"GO:0045956","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1701901314985614623","title":"Unknown","description":"The top GO terms are highly heterogeneous: includes nitric oxide signaling and biosynthesis, biosynthesis of porphyrinogen IX and biotin, tRNA methylation, fatty acid oxidation, hydrogen peroxide\u2013related programmed cell death, and developmental processes like chondrocyte differentiation. With no edges and only singleton terms, there is no clear shared function linking these proteins. Therefore a concise, representative label cannot be assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032332","count":2},{"id":"GO:0014740","count":1},{"id":"GO:0007263","count":1},{"id":"GO:0006809","count":1},{"id":"GO:0006782","count":1}]},{"hash":"1019802288460979167","title":"Rac/Rho GTPase\u2013driven actin remodeling","description":"This cluster centers on small GTPase signaling (Rac, Rho) and actin cytoskeleton dynamics, including lamellipodium assembly and cell spreading, indicating a cohesive theme of GTPase-regulated cytoskeletal remodeling. While some terms like insulin signaling, heart development, and myelin maintenance point to broader roles, the dominant signal is coordinated regulation of the actin cytoskeleton by Rac/Rho pathways.","confidence":"High","size":8,"edges":8,"triangles":1,"max_degree":6,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0008286","count":8},{"id":"GO:0030032","count":8},{"id":"GO:0035020","count":8},{"id":"GO:0007264","count":8},{"id":"GO:0032287","count":8}]},{"hash":"529932406850250416","title":"GABAergic Auditory/Sensory Synaptic Signaling","description":"The top GO terms cluster around GABAergic inhibition in sensory processing, especially auditory pathways, with terms for GABA receptor clustering, inhibitory postsynaptic potentials, and reduced nerve impulse transmission, plus supporting cues from sound perception and neural development/learning. This suggests a cohesive theme of GABA-mediated synaptic signaling in sensory circuits.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":4},{"id":"GO:0071805","count":3},{"id":"GO:1905906","count":3},{"id":"GO:0021631","count":3},{"id":"GO:0060080","count":3}]},{"hash":"503247459621349246","title":"Unknown","description":"The terms span membrane protein maturation (GPI anchor biosynthesis/attachment), mitochondrial import, oxidative stress responses and redox balance, metal ion homeostasis, autophagy regulation, and signaling/sensory perception, with no clear unifying function or pathway. Given the heterogeneity and lack of edges connecting the proteins, there isn\u2019t a coherent cluster theme to name beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046425","count":1},{"id":"GO:0050976","count":1},{"id":"GO:0006506","count":1},{"id":"GO:0016255","count":1},{"id":"GO:0045041","count":1}]},{"hash":"203503275880164839","title":"Female reproductive organ development","description":"The strongest signals come from GO terms for uterus development and female gonad development, suggesting a theme around development of female reproductive tissues. Digestive tract development is also present, which may reflect broader developmental roles or annotation noise, and several metabolic terms appear but don\u2019t form a cohesive alternative function. Therefore the label centers on female reproductive organ development. ","confidence":"Medium","size":8,"edges":9,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048565","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0008585","count":3},{"id":"GO:0019518","count":3},{"id":"GO:0033076","count":2}]},{"hash":"999764565848378362","title":"Unknown","description":"The top GO terms are highly diverse, including apoptotic process, herbicide response, several biosynthetic and catabolic pathways (porphyrin, lipoate, quinolinate, auxin, camphor, dopamine, glutamate), and even sperm capacitation. There is no single shared pathway or cohesive functional theme linking these terms, and the cluster has no edges, suggesting random or unrelated proteins. Therefore no intuitive, representative label can be assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0009635","count":1},{"id":"GO:0006782","count":1},{"id":"GO:0048240","count":1},{"id":"GO:0009106","count":1}]},{"hash":"2074923163114718029","title":"Plant pigment and pollen-wall biosynthesis","description":"The top GO terms point to plant-specific secondary metabolism (anthocyanin biosynthesis) and pollen-wall formation (sporopollenin biosynthesis). Additional terms for nucleotide-sugar biosynthesis (UDP-L-arabinose, dTDP-rhamnose, galacturonate, GDP-mannose) fit the production of polysaccharides and cell-wall components necessary for pollen coats and related structures. While an outlier like B cell chemotaxis appears, the dominant signal is plant pigment and pollen-wall biosynthesis, justifying this label.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009718","count":3},{"id":"GO:0035754","count":3},{"id":"GO:0006541","count":2},{"id":"GO:0033358","count":2}]},{"hash":"878685056442931162","title":"Structural polymer biosynthesis","description":"The GO terms cluster around biosynthetic processes for structural polymers and related glycans (lipopolysaccharide, suberin, sporopollenin, polyhydroxybutyrate) and their sugar-nucleotide precursors (dTDP-rhamnose, GDP-mannose), spanning diverse organisms. This suggests a shared theme of polymer assembly rather than a single precise pathway, justifying the label.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":1},{"id":"GO:0019305","count":1},{"id":"GO:0035002","count":1},{"id":"GO:0019673","count":1},{"id":"GO:0055114","count":1}]},{"hash":"995884739360107041","title":"ECM remodeling and fibrinolysis","description":"The cluster centers on proteolytic processes that remodel the extracellular matrix, including plasminogen activation, fibrinolysis, and ECM disassembly, with associated tissue remodeling and positive regulation of angiogenesis; trophoblast differentiation and lectin pathway complement activation may reflect specialized remodeling contexts, like placental invasion. This supports a cohesive theme of matrix proteolysis driving remodeling and angiogenesis.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0031639","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0048771","count":2},{"id":"GO:0001867","count":2}]},{"hash":"1854600830829103396","title":"Embryonic Development and Morphogenesis","description":"This cluster's top GO terms prominently center on development and morphogenesis across multiple tissues, including midbrain, heart outflow tract, eye, cranial skeleton, and placenta, with additional terms for multicellular development and fertilization. The negative regulation of transcription by RNA polymerase II likely reflects regulatory factors active during development; together they suggest a shared theme of embryonic and tissue morphogenesis.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0001890","count":4},{"id":"GO:0048701","count":4}]},{"hash":"851861346715033325","title":"Developmental morphogenesis and organogenesis","description":"Most terms describe embryonic development and tissue morphogenesis across multiple organs (nerve maturation, muscle regeneration, gland branching, kidney development, and lung morphogenesis), with signaling roles in ERK pathways and regulation of gastrulation and miRNA processing. This points to a developmental morphogenesis/organogenesis theme, hence the label.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021682","count":2},{"id":"GO:0043403","count":2},{"id":"GO:0060445","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0001525","count":2}]},{"hash":"1707610046151097874","title":"Diverse Metabolic Enzymes","description":"This cluster\u2019s GO terms span a wide range of metabolic processes\u2014biosynthesis and catabolism of various compounds (porphyrin, lipoate, quinolinate, camphor, propylene, dopamine, sulfur oxidation, etc.)\u2014rather than a single shared pathway. That broad, metabolism-focused pattern fits a label like \u201cDiverse Metabolic Enzymes\u201d without overcommitting to a specific function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":1},{"id":"GO:0009635","count":1},{"id":"GO:0006782","count":1},{"id":"GO:0009106","count":1},{"id":"GO:0019805","count":1}]},{"hash":"2268918897990167402","title":"Amino acid biosynthesis and catabolism","description":"The top GO terms show clear emphasis on amino acid metabolism, with L-tyrosine biosynthetic, L-valine biosynthetic, and L-alanine catabolic processes, along with the pentose-phosphate shunt indicating linked redox/energy metabolism. The placenta and liver development terms are likely contextual annotations rather than core functions of the cluster, so the dominant theme is amino acid metabolism and related metabolic pathways.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0009051","count":2},{"id":"GO:0046177","count":2}]},{"hash":"1015375047890401904","title":"Unknown","description":"The GO terms are diverse (heart development; muscle contraction; erythrocyte differentiation; nitric oxide transport; renal absorption; detoxification and oxidative stress responses; endocytosis; protein oligomerization), with no single cohesive function linking all 8 proteins. This lack of a shared theme makes it inappropriate to assign a concise, representative label beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0031444","count":1},{"id":"GO:0043353","count":1},{"id":"GO:0030185","count":1},{"id":"GO:0070293","count":1}]},{"hash":"644985186854610669","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":1},{"id":"GO:0042026","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0006458","count":1}]},{"hash":"1405120729098457030","title":"Neural development and axon guidance signaling","description":"The top GO terms cluster around nervous system development, axon guidance, Robo-Slit signaling, Hedgehog (Smoothened) signaling, and ERK/MAPK signaling, suggesting proteins involved in developmental signaling that shapes neural wiring; while some terms touch bone or kidney development, the neural development theme is strongest.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":3},{"id":"GO:0007411","count":3},{"id":"GO:0002551","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0070374","count":3}]},{"hash":"2108438084663279704","title":"Unknown","description":"The GO terms span animal brain and liver development, embryonic patterning, transcription regulation, DNA base-excision repair, and plant cell wall biosynthesis, with little overlap and only a single edge, indicating no coherent, single functional theme for this cluster.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0006284","count":2},{"id":"GO:0010417","count":2}]},{"hash":"2116154467345815418","title":"Unknown","description":"The top GO terms span phototransduction and cGMP signaling but also include diverse developmental processes, immune differentiation, and xenobiotic responses, with no single cohesive function tying all proteins together. Therefore, there is no clear functional theme to label the cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007603","count":3},{"id":"GO:0042053","count":3},{"id":"GO:0060658","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0048837","count":2}]},{"hash":"2261883829230450516","title":"ER Quality Control and Autophagy","description":"The terms cluster around ER-associated handling of misfolded proteins, including chaperone-assisted folding and degradation via autophagy (autophagosome maturation, late endosomal microautophagy), plus related ubiquitin-protease regulation and glycosylation steps, suggesting a proteostasis-focused group that links ERAD with autophagy pathways.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0071712","count":3},{"id":"GO:0032968","count":2},{"id":"GO:1903007","count":2},{"id":"GO:0070389","count":2}]},{"hash":"525352952836740386","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007341","count":1},{"id":"GO:0001661","count":1},{"id":"GO:0032275","count":1},{"id":"GO:0060023","count":1},{"id":"GO:0046884","count":1}]},{"hash":"1831097988957449013","title":"Neural development and synaptic signaling","description":"The strongest signal in the Top Terms is neural-focused, with nervous system development and excitatory postsynaptic potential pointing to neuronal development and synaptic activity. Other terms reflect broader developmental and cell-cycle processes that can accompany development, as well as immune and signaling pathways, but the core theme centers on neural development and signaling. ","confidence":"Medium","size":7,"edges":15,"triangles":11,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007286","count":4},{"id":"GO:0046330","count":4},{"id":"GO:0032707","count":4}]},{"hash":"1441396596424992023","title":"Histone acetylation-driven transcription regulation","description":"This cluster is dominated by GO terms tied to histone acetylation (H3/H4 acetylation) and regulation of DNA-templated transcription, with supporting developmental terms such as sensory organ precursor fate determination and imaginal disc development. The combination suggests proteins involved in epigenetic control of gene expression during development, likely histone acetylation regulators that modulate transcription. The presence of several obsolete acetylation terms reflects historical annotations but does not negate the core theme of histone modification guiding transcription in development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":1},{"id":"GO:0016360","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0043982","count":1},{"id":"GO:0046529","count":1}]},{"hash":"1656558761135980058","title":"Embryonic organogenesis and brain development","description":"The GO terms span broad embryonic development across multiple tissues (ear, limb, palate, digits, heart/outflow tract, skeletal system, pituitary) and include brain development and neuronal specification, suggesting a label focused on general organogenesis with neural involvement rather than a single tissue-specific process.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":5},{"id":"GO:0007626","count":4},{"id":"GO:0035116","count":4},{"id":"GO:0021902","count":4},{"id":"GO:0021983","count":4}]},{"hash":"1527351918587428485","title":"Embryonic Organogenesis and Immune Differentiation","description":"The cluster\u2019s top GO terms span heart development (cardiac tissue regeneration, endocardial cushion formation, valve morphogenesis), ear and lung organogenesis (otic vesicle and pneumocyte differentiation), thymic and T cell differentiation (thymic selection, pro-T and Th2 differentiation), plus estrogen response and erythrocyte differentiation. This pattern suggests a broad embryonic development/differentiation program across multiple tissues rather than a single tissue-specific function.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0061026","count":7},{"id":"GO:0045061","count":7},{"id":"GO:0071599","count":7},{"id":"GO:0060510","count":7},{"id":"GO:0043627","count":7}]},{"hash":"1667464152111787100","title":"Oogenesis Polarity and Axis Formation","description":"The terms cluster around oogenesis-related polarity and axis formation, including pole plasm localization, border follicle cell delamination, and epithelial polarity, pointing to a developmental polarity program. A few terms (nutrient detection, oxidative-stress\u2013related apoptosis) are less central but do not contradict the main theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090176","count":1},{"id":"GO:0051523","count":1},{"id":"GO:0006468","count":1},{"id":"GO:0030709","count":1},{"id":"GO:0007318","count":1}]},{"hash":"1108684149053763962","title":"Thymic T cell development and signaling","description":"The top GO terms cluster around thymic T cell development (beta selection, thymus development) and T cell receptor signaling, with supporting signals from related immune pathways (B cell receptor signaling, IL-4 production) and broader receptor-mediated signaling (PI3K activity, neurotrophin signaling). This points to a cohesive function in adaptive immune cell development and signaling, despite a few broader terms. Confidence: Medium","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043366","count":5},{"id":"GO:0010954","count":5},{"id":"GO:0048011","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0043552","count":5}]},{"hash":"1472585650055904227","title":"LPS Core Biosynthesis","description":"Top GO terms are dominated by lipopolysaccharide biosynthesis (including core region and ADP-L-glycero-beta-D-manno-heptose synthesis), suggesting the cluster groups enzymes involved in LPS assembly. Some dephosphorylation and general transport terms appear as broader annotations, but the strongest signal is LPS core biosynthesis.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":4},{"id":"GO:0099132","count":2},{"id":"GO:0006541","count":2},{"id":"GO:0014075","count":2},{"id":"GO:0030836","count":2}]},{"hash":"2195297788259273972","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":3},{"id":"GO:0071374","count":3},{"id":"GO:0071630","count":3},{"id":"GO:0006458","count":3},{"id":"GO:0036494","count":3}]},{"hash":"1998417423163135771","title":"Notch-regulated development and differentiation","description":"The top GO terms point to broad developmental processes across multiple tissues\u2014growth, gland and cardiac development, neuronal stem cell maintenance, and differentiation\u2014with a notable mention of Notch receptor processing. This pattern suggests a general developmental/differentiation program where Notch signaling may play a regulatory role, rather than a single, narrow function. ","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016049","count":4},{"id":"GO:0008306","count":4},{"id":"GO:0045061","count":3},{"id":"GO:0090260","count":3},{"id":"GO:0007220","count":3}]},{"hash":"122064573327356606","title":"Eye development and visual perception","description":"This cluster is dominated by vision-related GO terms such as retina development in camera-type eye, visual perception, and visual learning, pointing to a core theme centered on the visual system. Other terms like locomotory behavior and heart development are present but less representative. The strongest signal supports labeling the cluster as Eye development and visual perception.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0048148","count":3},{"id":"GO:0006468","count":3}]},{"hash":"1259373170787505820","title":"Vesicle trafficking and cytoskeleton assembly","description":"The GO terms cluster around secretory pathway and cytoskeletal processes: COPII-coated vesicle budding, apical protein localization, and regulation of vesicle exocytosis, together with tubulin complex assembly, pointing to vesicle transport and microtubule dynamics as the core theme. Although there are some diverse terms (brain development, ossification, keratinization), the strongest shared signal relates to vesicle trafficking and cytoskeletal organization.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0051301","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0000278","count":2}]},{"hash":"621688953191055978","title":"Neurovascular development","description":"GO terms point to neuronal activity (GABA secretion) and vascular sprouting/angiogenesis, with endocytic trafficking and membrane targeting that support signaling. Despite some broad terms (e.g., cell cycle), the recurring themes of neural signaling and angiogenesis suggest a neurovascular development role tying these proteins together. Therefore, Neurovascular development is a plausible, concise label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0000187","count":1},{"id":"GO:0046958","count":1},{"id":"GO:0014051","count":1},{"id":"GO:2000370","count":1}]},{"hash":"134503815022354604","title":"Neural crest\u2013related embryonic morphogenesis","description":"The terms point to embryonic tissue development with a focus on neural crest derivatives (neural crest migration, glial proliferation) and broad organ morphogenesis (eye closure, digestive tract, trachea), suggesting a cohesive theme of neural crest\u2013involved embryonic development.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061386","count":3},{"id":"GO:0048484","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0043388","count":3},{"id":"GO:0060534","count":2}]},{"hash":"952904143319918466","title":"Negative regulation of signaling and cell proliferation","description":"Based on the GO terms, the proteins are enriched for negative regulation of multiple signaling cascades (ERK1/ERK2, T cell receptor signaling, CDK activity) and for processes that restrain cell proliferation, with additional links to insulin signaling and neural development. The common thread appears to be dampening signaling output to control growth and differentiation, despite some terms relating to immune and neural contexts.","confidence":"Medium","size":7,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":3},{"id":"GO:0070373","count":3},{"id":"GO:0034501","count":3},{"id":"GO:0050860","count":3},{"id":"GO:0045736","count":3}]},{"hash":"529245202875855224","title":"Proteostasis and cell cycle regulation","description":"The cluster is enriched for protein quality control processes (ubiquitin-dependent ERAD, aggresome assembly, sumoylation, chaperone-assisted folding) alongside cell cycle and replication-related terms, suggesting a group of proteins that coordinate proteostasis with cell cycle progression and DNA replication. This indicates a cohesive theme around maintaining protein homeostasis while controlling replication/cell cycle dynamics.","confidence":"High","size":7,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0070842","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006270","count":2},{"id":"GO:0051726","count":2}]},{"hash":"2249858823358234242","title":"Endosomal Trafficking and MVB Sorting","description":"Dominant GO terms center on endocytosis and endosomal transport, including endosome-to-Golgi and Golgi-to-endosome routes, multivesicular body sorting, and targeting to vacuoles, suggesting a cohesive cluster of vesicular trafficking and cargo sorting in the endosomal/vacuolar pathway.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":1},{"id":"GO:0007565","count":1},{"id":"GO:0009997","count":1},{"id":"GO:0034498","count":1},{"id":"GO:0000147","count":1}]},{"hash":"1728202564543940395","title":"Neural development and synaptic adhesion","description":"This cluster is dominated by GO terms related to nervous system development, axon guidance, and promotion of synapse assembly, along with various cell\u2013cell and cell\u2013matrix adhesion terms, pointing to roles in neural development and synaptic organization. While there are some immune-related terms (antigen presentation via MHC I and regulation of cytotoxic lymphocyte activity), the strongest signal centers on neural development and adhesion. ","confidence":"Medium","size":7,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0035260","count":2},{"id":"GO:0042590","count":2}]},{"hash":"558837457967852552","title":"Unknown","description":"The top GO terms are disparate (brain boundary structural organization, hematopoietic progenitor differentiation) and include obsolete annotations about RNA polymerase II/III complex import, with no clear shared function or connectivity among the proteins. This lack of a coherent functional theme makes a meaningful, specific label inappropriate.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021552","count":1},{"id":"GO:1990022","count":1},{"id":"GO:0044376","count":1},{"id":"GO:0002244","count":1}]},{"hash":"845726234784906350","title":"Neural development and sensory cell differentiation","description":"This cluster\u2019s top GO terms are dominated by neural development and sensory cell fate specification, including midbrain-hindbrain boundary morphogenesis, neural retina development, cortical GABAergic interneuron differentiation, and auditory receptor cell fate specification. Although there are a few broader developmental terms (heart tube formation, hair cycle, estradiol response), the strongest signal centers on neural/sensory patterning and differentiation, suggesting these proteins function together in neural and sensory tissue development with supporting transcriptional regulation.","confidence":"Medium","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0021555","count":6},{"id":"GO:0003407","count":6},{"id":"GO:0021892","count":6},{"id":"GO:0003144","count":6}]},{"hash":"257323265578366054","title":"Developmental and physiological signaling","description":"The terms point to a broad theme of multicellular development (imaginal disc eversion, vessel maturation, ossification, embryo implantation) coupled with environmental and physiological responses (response to hypoxia, startle response, circadian regulation) and basic ion transport (potassium and calcium). This suggests a cluster of proteins involved in developmental regulation together with general physiological signaling and environmental responsiveness, rather than a single, cohesive pathway.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0098703","count":2},{"id":"GO:0001964","count":2}]},{"hash":"1425223205570847400","title":"Plant cell wall biosynthesis regulation and plasmodesmata organization","description":"The top GO terms point to plant-specific processes: regulation of plant-type cell wall cellulose biosynthesis and plasmodesma organization, with leaf morphogenesis also aligning with plant development. While several sugar catabolic terms and nitric oxide regulation are more peripheral, the core theme clearly centers on plant cell wall remodeling and intercellular transport via plasmodesmata, suggesting a cohesive, plant-focused cluster. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001009","count":1},{"id":"GO:0009831","count":1},{"id":"GO:0009663","count":1},{"id":"GO:0046477","count":1},{"id":"GO:0009965","count":1}]},{"hash":"1084713647641637128","title":"GPCR Signaling and Cytokine Regulation","description":"The proteins cluster around GPCR-mediated signaling pathways, including dopamine, histamine, and adrenergic receptor signaling that activate adenylate cyclase and MAPK pathways, alongside regulation of cytokine production (IL-6 and IL-1\u03b2) and eosinophil chemotaxis. While some terms like saliva secretion and visual learning are less typical, they can be linked through autonomic/G-protein signaling effects. Overall, a coherent theme is second-messenger GPCR signaling coupled to immune modulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032675","count":4},{"id":"GO:0046541","count":4},{"id":"GO:0008542","count":4},{"id":"GO:0071883","count":4},{"id":"GO:0034776","count":4}]},{"hash":"550290527360916154","title":"Embryonic Organogenesis","description":"The top GO terms cluster around embryonic development across multiple organs (placenta, uterus, eye, inner ear, lung morphogenesis, primitive streak), indicating a shared theme of morphogenesis during early development. A minor term about transcription regulation is present but does not redefine the main theme.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":4},{"id":"GO:0048048","count":4},{"id":"GO:0060065","count":3},{"id":"GO:0048839","count":3},{"id":"GO:0090009","count":3}]},{"hash":"1978127784587179560","title":"Neuronal signaling and calcium-dependent plasticity","description":"The GO terms center on neural activity and calcium dynamics: excitatory postsynaptic potential, calcium ion transport, axonogenesis, long-term memory, and drug responses (amphetamine, ethanol), plus locomotion. While astrocyte differentiation and EMT appear, the dominant theme is neuron-centric signaling and calcium-mediated plasticity, suggesting a neural signaling/plasticity module.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0006816","count":3},{"id":"GO:0001975","count":3},{"id":"GO:0007616","count":3},{"id":"GO:0045471","count":3}]},{"hash":"1000882711633468917","title":"Caveolin-mediated endocytosis and neuronal actin remodeling","description":"The genes are enriched for caveolin-mediated endocytosis regulation, actin cortex patch and filament assembly, dendritic spine maintenance, and insulin/IGF signaling, all linked by small GTPase\u2013regulated membrane trafficking and cytoskeletal remodeling. This pattern points to a cohesive module coordinating endocytosis with actin dynamics in neurons and synaptic maintenance, with some broader signaling contexts.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001286","count":5},{"id":"GO:1990314","count":5},{"id":"GO:0000147","count":5},{"id":"GO:0007264","count":5},{"id":"GO:0032287","count":5}]},{"hash":"845184148626780950","title":"Paranodal axon organization and guidance","description":"The top GO terms cluster around localization to the paranode region of the axon, paranodal junction assembly, and axon guidance via semaphorin-plexin signaling, suggesting a shared role in paranodal architecture and neuronal axon guidance. Some terms are more general or related to other processes, but the dominant theme is axon organization and guidance.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002175","count":6},{"id":"GO:0043552","count":4},{"id":"GO:0030913","count":4},{"id":"GO:0030513","count":4},{"id":"GO:0034164","count":4}]},{"hash":"871950177253340818","title":"Mitochondrial inner membrane protein insertion","description":"The top GO terms are focused on mitochondrial targeting and, specifically, insertion of proteins into the mitochondrial inner membrane, suggesting these proteins are involved in mitochondrial import/insertion processes. Although some terms are unrelated or obsolete and appear only sparsely, the strongest signal across the cluster points to mitochondrial inner membrane insertion. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":1},{"id":"GO:0072321","count":1},{"id":"GO:0045039","count":1},{"id":"GO:0003151","count":1},{"id":"GO:0035994","count":1}]},{"hash":"1739420991325641473","title":"Neuronal Synaptic Vesicle Cycling","description":"The GO terms highlight synaptic transmission and vesicle trafficking (excitatory postsynaptic potential; regulation of vesicle exocytosis and endocytosis) with related signaling (Rap and GTPase activity) and neural development contexts (substantia nigra development, cochlea morphogenesis). This suggests a cohesive cluster of proteins involved in neuronal vesicle cycling and its regulation, rather than unrelated pathways. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0032486","count":3},{"id":"GO:0090103","count":3}]},{"hash":"575587305841450431","title":"Unknown","description":"GO terms are too heterogeneous: angiogenesis and development work coexist with adaptive immune response, antigen processing, leukotriene biosynthesis, and even DNA transposition, providing no single cohesive function to bind the cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":1},{"id":"GO:0001525","count":1},{"id":"GO:0030154","count":1},{"id":"GO:0019885","count":1},{"id":"GO:0045766","count":1}]},{"hash":"1426591958232861408","title":"Immune activation and apoptotic regulation","description":"The top GO terms cluster around immune system processes (response to lipopolysaccharide, negative regulation of B cell proliferation, dendritic cell and T cell development signals like beta selection) and programmed cell death pathways (extrinsic apoptotic signaling, regulation of dendritic cell apoptotic process). While a few terms (estradiol response, neurotrophin signaling) are less directly related, the dominant theme ties immune activation with regulation of apoptosis. This suggests a cohesive cluster centered on immune signaling and apoptosis control.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032355","count":3},{"id":"GO:0048011","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0030220","count":3},{"id":"GO:0030889","count":3}]},{"hash":"1575302745049375028","title":"Nuclear RNA Processing and Surveillance","description":"This cluster is dominated by GO terms tied to nuclear RNA metabolism, including mRNA processing, nuclear mRNA surveillance, RNA decay pathways (deadenylation/decapping, RNA destabilization), and rRNA maturation, plus transcription termination. A few terms reference germline RNA granules (P granule and fusome organization), but the core theme appears to be nuclear RNA maturation and quality control. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0000466","count":1},{"id":"GO:1901919","count":1},{"id":"GO:0071035","count":1},{"id":"GO:0030723","count":1}]},{"hash":"876064017861890512","title":"Bacterial envelope lipid and sugar biosynthesis","description":"The GO terms indicate biosynthesis of cell envelope components (phospholipids, lipopolysaccharide) and envelope-relevant thiol cofactors (mycothiol, bacillithiol), alongside multiple sugar metabolic/response processes (glucose, sucrose, sorbitol, mannitol). Although there are no edges, these terms jointly suggest a theme around bacterial envelope lipid synthesis and carbohydrate metabolism. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008654","count":1},{"id":"GO:0010125","count":1},{"id":"GO:0005985","count":1},{"id":"GO:0071793","count":1},{"id":"GO:0009103","count":1}]},{"hash":"1684100212956055376","title":"Histone modification enzymes in development","description":"GO terms point to histone modification activities (H3 demethylation and deacetylation), suggesting proteins in this cluster are chromatin modifiers. Several development-related terms imply roles in development via regulation of gene expression, supporting an epigenetic/regulatory theme during morphogenesis. The lack of direct interactions within the cluster makes the label a best-fit generalization rather than a tight complex; thus the name reflects the shared function rather than specific partners.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070544","count":2},{"id":"GO:0034720","count":2},{"id":"GO:0045678","count":1},{"id":"GO:0090009","count":1},{"id":"GO:0060233","count":1}]},{"hash":"993644627979674293","title":"Rho/MAPK Signaling in Adaptive Immunity and Angiogenesis","description":"This cluster concentrates on signaling pathways involving Rho GTPases and MAPK cascades (ERK/JNK), with adaptive immune response and angiogenesis as prominent themes. Additional terms about microglial migration and extracellular matrix remodeling (hyaluronan metabolism) suggest involvement in neuroimmune and vascular remodeling contexts, supporting a cohesive theme of immune- and vascular-related signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007264","count":2}]},{"hash":"241830382666835469","title":"Multitissue Development Regulators","description":"The top GO terms point to kidney (metanephric) development, nervous system processes (axon guidance and protein localization in neurons), immune differentiation (B cell differentiation), and general developmental regulation (mesenchymal stem cell proliferation, ECM assembly). This suggests a group of proteins involved in broad developmental and signaling roles across multiple tissues, rather than a single cohesive pathway. Given the diversity and lack of interaction structure, this label approximates a general developmental regulator theme without overstating a specific function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":2},{"id":"GO:0001516","count":1},{"id":"GO:0071205","count":1},{"id":"GO:0090260","count":1},{"id":"GO:0002315","count":1}]},{"hash":"761873314408175550","title":"Unknown","description":"This cluster's top GO terms span disparate areas: skeletal muscle differentiation, germinal center formation, brassinosteroid signaling, viral latency, swimming, vesicle endocytosis, distal tubule morphogenesis, renal absorption, spindle midzone localization, and B cell receptor signaling. There is no clear, shared biological process or pathway connecting them, so a single cohesive function label cannot be established.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":1},{"id":"GO:0002467","count":1},{"id":"GO:0009742","count":1},{"id":"GO:0019046","count":1},{"id":"GO:0036268","count":1}]},{"hash":"257330962371670791","title":"Microtubule Assembly and Bundling","description":"The GO terms point to microtubule polymerization and microtubule bundle formation, indicating a function in microtubule assembly and organization. With seven proteins focused on these processes, the label reflects their shared role in building and bundling microtubules.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046785","count":1},{"id":"GO:0001578","count":1}]},{"hash":"2258437110287785216","title":"Brain signaling and metabolic regulation","description":"This label fits a core theme of neural signaling and plasticity (visual learning, excitatory postsynaptic potential, cocaine response) coupled with endocrine/metabolic pathways (insulin signaling, glucose metabolism, thyroid development). Peripheral terms like osmotic stress regulation and growth regulation are present but seem less central, so the cluster likely groups proteins involved in brain signal transduction with hormonal/metabolic regulation. ","confidence":"Medium","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":6},{"id":"GO:0047484","count":6},{"id":"GO:0008285","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0042220","count":6}]},{"hash":"798381584004943966","title":"Embryonic development and organogenesis","description":"The top GO terms cluster around morphogenesis and differentiation across developing tissues\u2014cartilage morphogenesis, endocardial cushion formation and EMT, left-right patterning, placenta and pancreatic development, and endocrine system formation\u2014pointing to broad embryonic organogenesis. A few metabolic terms appear incidental, but the dominant theme is developmental differentiation and organ formation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0003323","count":1}]},{"hash":"1484496210942485827","title":"Pollen Development and Exine Formation","description":"The top GO terms point to pollen biology in plants, especially anther dehiscence and pollen exine formation, suggesting a cluster of proteins involved in pollen maturation and wall assembly. Additional terms for N-linked glycosylation and nucleotide-sugar catabolism align with glycoprotein processing and polysaccharide/exine biosynthesis required for pollen wall formation, supporting a cohesive pollen-related function.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009901","count":4},{"id":"GO:0006487","count":4},{"id":"GO:0046032","count":4},{"id":"GO:0010584","count":4},{"id":"GO:0071405","count":4}]},{"hash":"800841103871305211","title":"GPCR-driven inflammatory cytokine regulation","description":"This cluster centers on immune/inflammatory signaling: regulation of IL-6 and IL-1\u03b2 production, eosinophil chemotaxis, and responses to histamine, coupled with GPCR-related pathways (MAPK-activating adrenergic signaling and adenylate cyclase activity). While a couple terms (saliva secretion, visual learning) seem less related, the dominant pattern points to GPCR-mediated regulation of cytokine production and inflammatory responses.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032675","count":4},{"id":"GO:0046541","count":4},{"id":"GO:0008542","count":4},{"id":"GO:0071883","count":4},{"id":"GO:0034776","count":4}]},{"hash":"1500455810234941075","title":"ECM Remodeling and Protein Turnover","description":"The GO terms cluster around extracellular matrix dynamics (negative regulation of ECM assembly, hyaluronan metabolism, cell adhesion) and proteolysis/protein turnover (ubiquitin-dependent catabolic process, proteasome assembly, metallopeptidase activity). These points together to a theme of extracellular matrix remodeling coupled with protein degradation, with a few outlier terms. Confidence: Medium.","confidence":"","size":6,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002291","count":2},{"id":"GO:0035987","count":2},{"id":"GO:1901202","count":2},{"id":"GO:0030212","count":2},{"id":"GO:0034113","count":2}]},{"hash":"470744281826575336","title":"Plant TOR signaling and cell cycle control","description":"This cluster centers on TORC1 signaling and cell division processes, including mitotic chromosome condensation and meiotic cohesion, with plant-specific context such as amyloplast organization and microsporogenesis, suggesting a cohesive module coordinating growth signaling with cell-cycle events in plants.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070262","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0038202","count":2},{"id":"GO:0051301","count":2}]},{"hash":"2133629740476455925","title":"Calcium/Ion Homeostasis and NO Signaling","description":"The GO terms cluster around ion homeostasis (calcium, potassium, sodium), calcium transport between cytosol and organelles (ER, Golgi), and regulation of NO-related pathways, including NOS activity and NO signaling, plus PKA activity. This suggests a cohesive module coordinating intracellular ion balance with calcium-related signaling and NO regulation, potentially impacting cardiac signaling. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000481","count":5},{"id":"GO:0051001","count":5},{"id":"GO:0098736","count":5},{"id":"GO:0030007","count":5},{"id":"GO:0061454","count":5}]},{"hash":"1145505564589035806","title":"Actin-based vesicle transport and organelle inheritance","description":"The cluster is enriched for GO terms centered on actin-mediated vesicle movement and docking, along with inheritance of organelles like vacuoles and mitochondria. This points to a coherent theme of cytoskeleton-driven intracellular trafficking and partitioning of organelles, with some developmental/signaling terms likely reflecting broader cellular context.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000011","count":3},{"id":"GO:0000147","count":3},{"id":"GO:0014728","count":3},{"id":"GO:0030050","count":3},{"id":"GO:0000001","count":3}]},{"hash":"804510530763206300","title":"Neural development and synaptic regulation","description":"This cluster centers on neural-related processes: inhibitory synapse assembly, regulation of glutamate uptake involved in neurotransmission, and neural fold elevation formation, suggesting roles in neural development and synaptic function. Other terms point to transcription/translation regulation and broader cellular processes, but the neural development/synaptic theme is the most coherent common thread across the top terms. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070932","count":1},{"id":"GO:1904862","count":1},{"id":"GO:0021502","count":1},{"id":"GO:0051946","count":1},{"id":"GO:0061419","count":1}]},{"hash":"412695981439890162","title":"Cerebral Cortex GABAergic Interneuron Development","description":"Dominant GO terms describe neural development, especially cerebral cortex GABAergic interneuron differentiation and fate commitment, along with forebrain patterning and midbrain development. A few terms relate to broader embryogenesis, but the neural development signals are strongest, justifying a label focused on cortex interneuron development.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0021759","count":4},{"id":"GO:0090009","count":3},{"id":"GO:0021892","count":3},{"id":"GO:0021798","count":3}]},{"hash":"695177181676679535","title":"Translational Initiation and RNA Processing","description":"The top GO terms are dominated by translation initiation and its regulation (eIF4F complex assembly, regulation of translational initiation, IRES-dependent initiation) and miRNA-mediated translational silencing, indicating a cluster centered on post-transcriptional control of gene expression. A few RNA-processing terms (splice site recognition, poly(A) tail regulation) support the broader RNA-level regulation theme, not a specific single pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0097010","count":1},{"id":"GO:1902625","count":1},{"id":"GO:0075522","count":1}]},{"hash":"2100678486441619479","title":"Actin Cytoskeleton Organization and Cell Polarity","description":"The top terms are dominated by actin-related processes (Arp2/3-mediated nucleation, actin cortex, postsynaptic actin organization) and events tied to cell shape and polarity, indicating a coherent theme of actin remodeling driving cellular morphology and orientation. A few items hint at broader nuclear or inheritance roles, but the prevailing signal supports an actin-centered cluster.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034314","count":5},{"id":"GO:0098974","count":5},{"id":"GO:0043486","count":5},{"id":"GO:0000011","count":5},{"id":"GO:0071963","count":5}]},{"hash":"1718789416101577728","title":"Membrane excitability and ion transport","description":"The cluster is enriched for GO terms related to neural and cardiac electrical activity (GABA secretion; neuronal action potential; depolarization in atrial and Purkinje cells) and ion transport (sodium and calcium), indicating a shared function in membrane excitability and ion handling. Some development-related terms (tubule and lymph vessel morphogenesis) appear but are less central to the core theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014051","count":2},{"id":"GO:0098912","count":2},{"id":"GO:0072237","count":2},{"id":"GO:0072287","count":2},{"id":"GO:0036303","count":2}]},{"hash":"298778976867514773","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0036205","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0051865","count":4},{"id":"GO:1903265","count":4}]},{"hash":"2047876253042145972","title":"Chromatin remodeling with plant hormone signaling","description":"The cluster centers on chromatin dynamics (chromatin remodeling, nucleosome assembly, subtelomeric heterochromatin formation, DNA repair) and co-occurs with diverse plant hormone and defense signals (ABA, salicylic acid, cytokinin, insulin signaling). This pattern suggests a module where chromatin state interfaces with developmental and stress-related hormonal pathways, rather than a single linear pathway. ","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0051534","count":2},{"id":"GO:0006334","count":1}]},{"hash":"828467119488125710","title":"Developmental signaling in neural and cardiac lineages","description":"The top GO terms center on developmental signaling and lineage specification in neural tissues (forebrain regionalization, spinal cord neuron differentiation, cerebellar precursor signaling) as well as heart development (atrial cardiac muscle cell development). Additional terms point to cytoskeletal dynamics (actin filament bundle assembly), trafficking (slow endocytic recycling), and gene regulation (miRNA silencing) that commonly accompany developmental processes. Together, they suggest a cluster of proteins coordinating developmental signaling across neural and cardiac lineages with supporting cytoskeletal and regulatory roles.","confidence":"Medium","size":6,"edges":9,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070886","count":6},{"id":"GO:0055014","count":6},{"id":"GO:0051017","count":6},{"id":"GO:2000744","count":6},{"id":"GO:0021871","count":6}]},{"hash":"461072453696233277","title":"RNA processing and ribosome biogenesis","description":"The terms cluster around RNA metabolism (mRNA decay, RNA surveillance, maturation) and ribosome biogenesis (rRNA maturation, translation), with additional signals for transcription and chromatin remodeling\u2014together suggesting a group focused on RNA processing and ribosome assembly rather than a single specific pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070481","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043044","count":2},{"id":"GO:0000466","count":1},{"id":"GO:0071025","count":1}]},{"hash":"2102625709574239225","title":"Unknown","description":"The top GO terms cover a wide and unrelated mix of processes (pain perception, muscle stretch response, endothelial and adipose differentiation, immune signaling, calcium signaling, and cardiac SA node regulation) with no clear common biological theme or interaction pattern, so there isn\u2019t a coherent function defining this cluster. Confidence: None.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":1},{"id":"GO:0060843","count":1},{"id":"GO:1903444","count":1},{"id":"GO:0071642","count":1},{"id":"GO:0050968","count":1}]},{"hash":"247645954019590379","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":2},{"id":"GO:0042026","count":2},{"id":"GO:0071630","count":2},{"id":"GO:0071374","count":2},{"id":"GO:0006458","count":2}]},{"hash":"2298073689481388036","title":"Fungal mating and cell wall biosynthesis","description":"Top GO terms include karyogamy involved in conjugation with cellular fusion and fungal-type cell wall beta-glucan biosynthetic process, both clearly fungal-specific, suggesting a focus on fungal development, mating, and cell wall construction. While some terms are generic or obsolete, these dominant fungal-related processes provide a coherent theme for the cluster. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":5},{"id":"GO:1903382","count":5},{"id":"GO:0090084","count":5},{"id":"GO:0070880","count":5},{"id":"GO:0031204","count":5}]},{"hash":"204404667608896845","title":"Germ Cell Development and Translational Regulation","description":"The top GO terms center on spermatid differentiation and male meiosis processes, indicating a germline development theme. Concurrently, translation-related terms (translation, cap-dependent translational initiation, negative regulation of translation) suggest active post-transcriptional control in these cells, which is key during spermatogenesis. Additional terms about autophagy regulation and stem cell maintenance fit with germ cell maturation and germline stem cell biology, while a few terms related to neuronal differentiation or behavior may reflect broader pleiotropy. Overall, the cluster is best described as germ cell development with translational regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048515","count":1},{"id":"GO:0007112","count":1},{"id":"GO:0045665","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0002191","count":1}]},{"hash":"1793519474389624641","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0008283","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0075522","count":2}]},{"hash":"2061927752368114790","title":"Brain Development and Synaptic Signaling","description":"The most represented GO terms center on neural processes: embryonic cranial skeleton morphogenesis (cranial development), visual learning, excitatory postsynaptic potential, and response to cocaine, suggesting a cluster of genes involved in brain development and synaptic activity. The presence of innate immune and dsRNA response terms may reflect pleiotropic roles or cellular stress responses, but the dominant signal points to neural signaling and brain-related function.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":4},{"id":"GO:0043330","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0008542","count":3}]},{"hash":"2115314759179471796","title":"Muscle development and regeneration signaling","description":"The cluster centers on muscle-related processes: satellite cell activation and skeletal muscle regeneration, regulation of muscle contraction (filament sliding), and cardiac muscle hypertrophy, with angiogenesis supporting tissue growth and repair. While there are broader developmental terms present (ear and gland development), the strongest shared signal is muscle development and regeneration.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033234","count":2},{"id":"GO:0030916","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0014718","count":2}]},{"hash":"1531160092254701486","title":"Translational Regulation and mRNA Processing","description":"This cluster is dominated by GO terms about controlling translation initiation and translation itself (eIF4F complex assembly, regulation of translational initiation, IRES-dependent viral translation, viral termination-reinitiation) and by RNA silencing mechanisms that inhibit translation (miRNA-mediated silencing). It also includes RNA processing and stability aspects (mRNA poly(A) tail shortening, mRNA splice site recognition, stress-related mRNA stability), pointing to a cohesive function: coordination of translation with RNA processing and turnover.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":5},{"id":"GO:0097010","count":4},{"id":"GO:1902625","count":4},{"id":"GO:0075522","count":4},{"id":"GO:1903586","count":4}]},{"hash":"585917439934598136","title":"RNA processing and translational regulation","description":"The GO terms point to post-transcriptional control: ncRNA- and miRNA-mediated gene silencing, regulation of mRNA splicing via the spliceosome, assembly of translation initiation complexes, IRES-driven translation, and regulation of translation initiation and poly(A) tail dynamics. Together they depict a cluster of proteins involved in RNA processing and control of gene expression at the RNA level, spanning splicing decisions to translational efficiency.","confidence":"Medium","size":6,"edges":7,"triangles":4,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0097010","count":4},{"id":"GO:1902625","count":4},{"id":"GO:0075522","count":4}]},{"hash":"1636089140870279752","title":"Unknown","description":"The top terms span a highly heterogeneous mix: antibiotic response, SOS response, redox processes, TNF signaling regulation, transport and lipid translocation, autophagy-related endosomal processes, septum assembly, and even obsolete aging and glycosylation terms. This lack of a single cohesive function or pathway, along with annotation noise (obsolete terms), makes it unclear how these proteins conceptually relate as a unit.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0010804","count":2},{"id":"GO:0018279","count":1}]},{"hash":"1382409929241216844","title":"Neural development and dendrite morphogenesis","description":"The top GO terms point strongly to nervous system development, CNS neuron development, and dendrite morphogenesis, with additional related processes such as neurodevelopment, cell migration, and Wnt signaling modulation that are known to influence neural patterning and morphogenesis. While there are broader terms like transcription and ion transport, the repeated emphasis on neural development and dendritic shaping suggests proteins involved in neuronal differentiation and morphology. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0090090","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0006813","count":2}]},{"hash":"1769537564327629508","title":"Developmental Regulation and Stress Responses","description":"The cluster shows multiple GO terms centered on developmental processes (multicellular organism development, forebrain, skeletal system, skin development) and transcriptional control, plus actin cytoskeleton remodeling and stress-related pathways (cadmium response, ER stress\u2013induced apoptosis) and defense. This pattern suggests a module that coordinates tissue development with cellular stress signaling, rather than a single specific pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0001501","count":2},{"id":"GO:2000601","count":2},{"id":"GO:0043588","count":2}]},{"hash":"1197526973558944691","title":"Neuronal signaling and motor function","description":"This cluster centers on neural development and activity: neuron migration, maintenance of synapse structure, locomotory behavior, and motor learning, along with GPCR-linked signaling and energy metabolism essential for neurons. The combination suggests a cohesive neural signaling and motor-control module, with some endocrine and reward-related terms included.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0007626","count":3}]},{"hash":"1222629569324568392","title":"Translational Machinery and Selenocysteine Incorporation","description":"The top GO terms are dominated by translation-related processes (translation, cytoplasmic translation, translational termination, selenocysteine incorporation, and regulation of translational fidelity), indicating this cluster mainly comprises components of the protein synthesis machinery and its regulation. A few terms (nitrate assimilation, glial cell proliferation, RNA-templated transcription, response to antibiotic) are less central and may reflect additional functions of bundled proteins. Overall, the cluster represents translation machinery and its regulation.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0002184","count":1},{"id":"GO:0006415","count":1}]},{"hash":"122159160564478472","title":"Golgi\u2013endosome transport and vacuolar protein targeting","description":"This cluster is dominated by GO terms for Golgi\u2013endosome traffic, early endosome\u2013Golgi exchange, multivesicular body sorting, endocytosis, and protein targeting to the vacuole, all pointing to an integrated vesicle trafficking and cargo-sorting function within the endomembrane system. Minor viral-related terms appear infrequently and do not define the core theme.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006895","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0071985","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0006623","count":2}]},{"hash":"1941287076476899680","title":"Cardiac Muscle Ion Transport and Signaling","description":"The top GO terms combine muscle-specific processes (sarcomere organization, cardiac muscle cell proliferation) with ion transport and membrane potential regulation (potassium/sodium transport, membrane potential regulation) and signaling (cGMP response, adenylate cyclase activity). While a couple terms appear less related (e.g., transcription repression, bud neck localization), the dominant theme centers on cardiac muscle-related ion transport and signaling mechanisms.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0071805","count":1},{"id":"GO:0098719","count":1},{"id":"GO:0060038","count":1},{"id":"GO:0007264","count":1}]},{"hash":"767555655449858736","title":"Neural development and synaptic signaling","description":"This cluster is enriched for GO terms related to nervous system and brain development and synaptic function, including nervous system development, brain development, synaptic transmission (GABAergic), and excitatory postsynaptic potentials. Other terms such as apical protein localization and substrate adhesion-dependent cell spreading reflect broader developmental or cellular polarity processes that often accompany neural differentiation. The strongest signal concerns neural development and neurotransmission, so the proposed label emphasizes those core activities.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0051932","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0031424","count":3},{"id":"GO:1900026","count":3}]},{"hash":"1456783775837642369","title":"Neural development and signaling","description":"Most terms point to neural development and synaptic signaling (axon guidance, synapse assembly, pain perception) with supporting cell\u2013matrix signaling and survival pathways; a few terms about skin/adipose differentiation are peripheral to the core theme.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0034351","count":3},{"id":"GO:0036120","count":3},{"id":"GO:2000811","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0008045","count":3}]},{"hash":"895539945985210169","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070814","count":1},{"id":"GO:0009970","count":1},{"id":"GO:0019344","count":1},{"id":"GO:0010134","count":1},{"id":"GO:0019379","count":1}]},{"hash":"1598140945900148515","title":"Ubiquitin-mediated cell cycle regulation","description":"The top GO terms show strong emphasis on ubiquitination and ubiquitin-dependent protein catabolic processes, including protein polyubiquitination, alongside cell cycle-related controls such as regulation of DNA replication initiation, mitotic G1 checkpoint signaling, spindle assembly, and negative regulation of cell proliferation. While a few terms relate to metal stress or synaptic processes, the dominant pattern ties protein turnover via ubiquitination to cell cycle regulation, justifying a combined label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0008285","count":4},{"id":"GO:0071406","count":4},{"id":"GO:0030174","count":4}]},{"hash":"1900525230664165147","title":"Tissue morphogenesis and cell adhesion","description":"The top GO terms cluster around tissue development, morphogenesis, and cell\u2013cell or cell\u2013matrix interactions (ossification, exocrine development, adherence junctions, focal adhesion, polarity, wound healing, satellite cell migration). While some terms reflect general cellular processes (mitotic spindle, synaptic potential), the common theme is development and remodeling of tissues driven by adhesion, polarity, and intercellular communication. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":5},{"id":"GO:0035272","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0090307","count":4},{"id":"GO:1902766","count":4}]},{"hash":"80034405530339629","title":"Unknown","description":"The GO terms span diverse developmental contexts (retinal, tracheal, lymphatic/endothelial fate, neuron timing, sex determination) and lipid/metabolic processes (cholesterol homeostasis, phosphatidic acid biosynthesis) with no single shared function linking the proteins; there is no coherent theme to name a specific cluster function.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003406","count":1},{"id":"GO:0060164","count":1},{"id":"GO:0060534","count":1},{"id":"GO:0071376","count":1},{"id":"GO:0060838","count":1}]},{"hash":"2166546726308946723","title":"Actin Cytoskeleton Remodeling and Cell Adhesion","description":"This cluster centers on actin cytoskeleton dynamics (actin filament bundle assembly, podosome assembly, stress fiber regulation) and cell\u2013adhesion signaling (integrin-mediated pathways, tight junction assembly, centrosome-related localization), suggesting proteins involved in remodeling the actin network and coordinating cell\u2013substrate and cell\u2013cell contacts. The fungal-origin response term is present but secondary to the dominant cytoskeletal/adhesion theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":4},{"id":"GO:0051017","count":3},{"id":"GO:0042518","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0007229","count":3}]},{"hash":"900731161023679160","title":"Cardiac Action Potential and Ion Channel Regulation","description":"The cluster is dominated by terms related to heart rate regulation via cardiac conduction, atrial repolarization, regulation of resting membrane potential, potassium import across the plasma membrane, and cardiac muscle action potential involved in contraction, all pointing to cardiac electrophysiology and ion channel control. A few terms on estradiol response or synaptic plasticity appear incidental, but the core theme centers on cardiac ion channel activity and membrane potential dynamics.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"nervous system process","top_go_terms":[{"id":"GO:0086091","count":4},{"id":"GO:0098914","count":4},{"id":"GO:0060075","count":4},{"id":"GO:1990573","count":4},{"id":"GO:0086002","count":4}]},{"hash":"963113216748819477","title":"Embryonic Development & Organogenesis","description":"Top terms range from primitive streak formation to patterning and differentiation in brain regions (cerebral cortex GABAergic interneurons) and other organs (bronchioles, thyroid, digestive tract, heart vasculature), suggesting a cluster of proteins involved in broad embryonic development and organ formation rather than a single pathway.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":1},{"id":"GO:0021892","count":1},{"id":"GO:0021798","count":1},{"id":"GO:0030901","count":1},{"id":"GO:0048557","count":1}]},{"hash":"183288176567460154","title":"Neuronal signaling and sensory processing","description":"This cluster is dominated by neural and sensory-related terms: sensory perception of sound, optic nerve morphogenesis, locomotory behavior, inhibitory postsynaptic potential, GABA receptor clustering, and response to nicotine. Potassium ion transmembrane transport supports neuronal excitability, tying these terms to neuronal signaling and sensory processing. While a couple terms touch on bone maturation and amyloid regulation, the strongest shared theme is neural development and synaptic function.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0043931","count":2},{"id":"GO:1905906","count":2}]},{"hash":"1322485353171859299","title":"Bacterial membrane transporters for nutrients and xenobiotics","description":"This cluster centers on a set of membrane-associated transport activities spanning vitamins, amino acids, thiamine, lipids, and xenobiotics, plus related functions like teichoic acid transport and bacteriocin immunity. The shared theme is transmembrane movement of diverse small molecules, typical of bacterial transport systems, making a label that emphasizes nutrient and xenobiotic transport appropriate and concise.","confidence":"Medium","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0042891","count":3},{"id":"GO:0015803","count":2},{"id":"GO:0015888","count":2}]},{"hash":"1937663984322960074","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0002250","count":2},{"id":"GO:1900042","count":2}]},{"hash":"932752910395145254","title":"Hematopoietic and immune cell differentiation","description":"The top GO terms point to lineage specification and development within the hematopoietic/immune system, including macrophage foam cell differentiation, B cell differentiation, megakaryocyte development, and general cell fate commitments. This indicates the cluster is enriched for proteins involved in guiding immune/blood cell lineages, with additional contextual regulation suggested by estrogen/UV responses. Some terms appear more general or contextual, but the central theme is hematopoietic/immune differentiation.","confidence":"Medium","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010742","count":2},{"id":"GO:0043923","count":2},{"id":"GO:0090043","count":2},{"id":"GO:0043627","count":2},{"id":"GO:0034644","count":2}]},{"hash":"1184331721658246542","title":"Auditory neural development and synapse assembly","description":"This cluster centers on neural development and synapse-related processes, including axon guidance, synapse assembly/maturation, and chemical synaptic transmission, with a specific nod to inner ear stereocilium organization. While a few terms like vocal learning and myoblast development appear, the dominant signal ties to building and functioning neural circuits, particularly in the auditory pathway.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903553","count":1},{"id":"GO:0007411","count":1},{"id":"GO:0007416","count":1},{"id":"GO:0048627","count":1},{"id":"GO:0090126","count":1}]},{"hash":"1586286206911272039","title":"Actin Cytoskeleton Polarity Regulators","description":"Most top GO terms point to establishment or maintenance of actin cytoskeleton polarity and cell shape (e.g., actin cytoskeleton polarity, cell polarity). Additional terms about membrane remodeling (lipid tube assembly in organelle fission) and positive regulation of GTPase activity support a theme of cytoskeletal remodeling governed by GTPases. Some terms hint at neuronal context (BDNF response, subsynaptic reticulum), suggesting involvement in neuronal cytoskeletal organization, but the dominant signal is actin-driven polarity and cytoskeletal dynamics.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0060990","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1190971097935740469","title":"Unknown","description":"The GO terms are scattered across redox homeostasis, corneocyte development, DNA repair, mRNA stability, PI signaling, aging, and other diverse processes, with no clear single pathway or function linking the proteins. The lack of a cohesive theme and the absence of network connectivity make it inappropriate to assign a specific, descriptive label.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0043488","count":2}]},{"hash":"1176250568853842314","title":"Diverse metabolite biosynthesis","description":"The GO terms are all about biosynthetic processes for a wide range of metabolites (phylloquinone, melanin, androgens/estrogens, fatty acids, antibiotics, retinoic acid, glucocorticoids, etc.), indicating the proteins participate in diverse biosynthetic pathways rather than a single pathway. This makes \"Diverse metabolite biosynthesis\" a concise, representative label.","confidence":"High","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042376","count":4},{"id":"GO:0042438","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0006710","count":4},{"id":"GO:0042619","count":4}]},{"hash":"2044311894324042851","title":"Unknown","description":"The GO terms span diverse processes (protease regulation, wound response, redox balance, cell migration, skin/corneocyte development, aging, RNA stability, PI signaling, DNA repair, and inter-organism hemolysis) with no clear shared function or pathway. With no edges linking the proteins, there isn\u2019t a coherent theme to name the cluster beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":1},{"id":"GO:0009611","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0014912","count":1},{"id":"GO:0003335","count":1}]},{"hash":"1108798816703881309","title":"NF-\u03baB/JNK immune signaling regulators","description":"This cluster centers on immune signaling pathways (I-kappaB phosphorylation, TNF signaling, JNK cascade) and lymphocyte development processes (V(D)J recombination), with some hints of transcriptional regulation via histone modification; together these suggest proteins functioning as regulators of immune signaling and gene expression in immune contexts.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070512","count":4},{"id":"GO:0036205","count":4},{"id":"GO:1903721","count":4},{"id":"GO:1901253","count":4},{"id":"GO:0033151","count":4}]},{"hash":"123722698047606668","title":"Cranial nerve and sensory ganglion development","description":"The top GO terms cluster around cranial nerve and sensory ganglion formation, including facioacoustic ganglion development, otic placode development, facial nerve organization, and sympathetic ganglion development, plus neural crest migration. A few terms like endosome localization or receptor tyrosine kinase activation are broader or possibly incidental, but the dominant signal points to cranial nerve/sensory ganglion developmental processes.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903375","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0021612","count":1},{"id":"GO:1905040","count":1},{"id":"GO:0021828","count":1}]},{"hash":"1516069188550217030","title":"Vascular and Smooth Muscle Differentiation","description":"Based on the GO terms, the cluster shows a consistent signal for muscle lineage development in vascular and cardiac contexts, including ventricular cardiac muscle cell differentiation and vascular-associated smooth muscle cell differentiation. Uterus development also points to muscle-related development pathways. Other terms like protein sumoylation and histone mRNA catabolic process appear peripheral to the main theme, suggesting these proteins may participate in broader cellular processes but collectively the dominant pattern is muscle differentiation in vascular and heart tissues.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":1},{"id":"GO:0055012","count":1},{"id":"GO:0097680","count":1},{"id":"GO:0035886","count":1},{"id":"GO:2000721","count":1}]},{"hash":"2155773740550235836","title":"Embryonic Morphogenesis and Differentiation","description":"This cluster centers on developmental processes and tissue morphogenesis across multiple lineages (EMT in heart development, cartilage morphogenesis, left-right patterning, brain boundary morphogenesis, and endocrine/pancreatic lineage development), suggesting a broad role in embryonic differentiation rather than a single pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003323","count":2}]},{"hash":"2247580716391134912","title":"Neuronal Axon Guidance and Synapse Assembly","description":"The GO terms converge on neuronal development: axonogenesis, axon guidance, synapse assembly, and glutamatergic transmission, with adhesion processes that help establish neuronal connections and synaptic function, especially in the peripheral nervous system.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048936","count":4},{"id":"GO:0008045","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0051968","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1666156710507511695","title":"Diverse biosynthesis of lipids, vitamins, and pigments","description":"GO terms show a mix of biosynthetic processes across lipids, vitamins, pigments, and hormones, with some secondary metabolite biosynthesis (antibiotics, PHB). There is no single dominant pathway, so the cluster is best described as diverse small-molecule biosynthesis rather than a specific pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042572","count":3},{"id":"GO:0042376","count":2},{"id":"GO:0042438","count":2},{"id":"GO:0006710","count":2}]},{"hash":"726169603369789561","title":"Adaptive immunity and angiogenesis signaling","description":"Top GO terms indicate a core theme of adaptive immune response and angiogenesis, with a strong link to ERK/MAPK signaling (positive regulation of ERK1/ERK2 cascade). This suggests the protein set may be involved in immune activation that also promotes vascular growth via MAPK pathways. Some other terms (vesicle fusion regulation, phagocytosis, virion attachment) appear peripheral or reflective of broader immune processes, but do not override the central immune-angiogenesis theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0032889","count":1},{"id":"GO:0031338","count":1}]},{"hash":"609905896657064102","title":"GABAergic Synapses and Neural Sensory Processing","description":"The terms cluster around inhibitory synaptic signaling and neural sensory functions: GABA receptor clustering and inhibitory postsynaptic potentials point to GABAergic synapses, while sensory-related terms (sound perception, optic nerve morphogenesis, conditioned taste aversion) reflect broader neural sensory processing. Some other terms (potassium transport, skeletal muscle growth, amyloid regulation) are supportive but not central to the core theme.","confidence":"High","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048630","count":4},{"id":"GO:0071805","count":3},{"id":"GO:1905906","count":3},{"id":"GO:0021631","count":3},{"id":"GO:0060080","count":3}]},{"hash":"1726473368215583473","title":"Ribosome assembly, translation, and DNA replication","description":"Based on the top GO terms, the cluster centers on protein synthesis and genetic information processing: ribosomal large subunit assembly and translation are prominent, with DNA replication also represented. A few metabolic/redox-related terms (mitochondrial ATP synthesis, NADPH regeneration, glutathione metabolism, oxidative stress) appear but are less frequent, suggesting background connectivity to energy and redox status rather than a distinct separate pathway. Overall, the dominant theme is core gene expression machinery.","confidence":"Medium","size":6,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0017148","count":1},{"id":"GO:0042775","count":1}]},{"hash":"59667081396502289","title":"Neurodevelopment and sensory organ formation","description":"The top GO terms cluster around brain and inner ear development, locomotory behavior, and synapse assembly, indicating roles in neural development and sensory organ formation. While there are additional terms covering broader developmental processes (pituitary development, transcription regulation, hair orientation), the strongest signal is neural/sensory development, suggesting this as the core theme for the cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":4},{"id":"GO:0007626","count":3},{"id":"GO:0045317","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0051965","count":3}]},{"hash":"1806515642036581251","title":"Glutamatergic synapses and nervous system development","description":"The cluster includes terms emphasizing glutamatergic synapse formation, synaptic transmission, and broader nervous system development, with supporting inner ear/labyrinthine layer development terms, suggesting roles in neural/sensory development and synaptic wiring.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0060711","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0048839","count":2}]},{"hash":"308500664875984373","title":"Unknown","description":"The six proteins show a highly heterogeneous set of GO terms spanning blood cell differentiation, insect gland development, macrophage foam cell differentiation, host\u2013virus interactions, cytoskeletal and epigenetic regulation, and signaling, with no clear single function or pathway tying them together. The lack of a common theme and the presence of obsolete terms imply this cluster cannot be confidently labeled as a cohesive biological process.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002574","count":1},{"id":"GO:1903699","count":1},{"id":"GO:0010742","count":1},{"id":"GO:0043923","count":1},{"id":"GO:0090043","count":1}]},{"hash":"241943557083455556","title":"Unknown","description":"The GO terms span very diverse biological contexts (ubiquitin-dependent protein degradation, muscle differentiation, germinal center formation, plant hormone signaling, viral latency release, swimming behavior, synaptic vesicle endocytosis, kidney development and function, and mitotic spindle processes), with no single shared function or pathway connecting all proteins. This suggests a heterogeneous cluster without a coherent functional theme.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0035914","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0009742","count":2},{"id":"GO:0019046","count":2}]},{"hash":"2244604503143151588","title":"Ubiquitin-Proteasome Regulation of NF-\u03baB and Immune Signaling","description":"The terms show a strong emphasis on ubiquitination and proteasomal degradation (polyubiquitination, SCF-dependent proteasomal degradation) with coordinated control of NF-\u03baB signaling and apoptosis, plus TLR9-mediated immune signaling. This suggests a cluster of regulators that modulate immune responses and cell survival via the ubiquitin-proteasome system, rather than a single linear pathway. Some neural-term annotations appear but do not override the dominant ubiquitin\u2013immune signaling theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0043124","count":2}]},{"hash":"65526173751746340","title":"RNA and Protein Methylation","description":"The GO terms are dominated by methylation-related processes, including RNA methylation (7-methylguanosine mRNA capping, tRNA methylation) and various peptidyl methylations (arginine, lysine, glutamine), indicating a cluster centered on methylation modifications. A couple of terms point to xenobiotic or cocaine response, suggesting broader stress-related regulation, but the primary signal supports an RNA and protein methylation theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":1},{"id":"GO:0030961","count":1},{"id":"GO:0018027","count":1},{"id":"GO:0036265","count":1},{"id":"GO:0006972","count":1}]},{"hash":"1010995459400851820","title":"Chaperone-Mediated Protein Folding","description":"The top GO terms point to ATP-dependent chaperone activity, with strong signals for protein refolding and chaperone-mediated complex assembly, suggesting the proteins function together as molecular chaperones. Some other terms in the set appear unrelated (e.g., RNA localization, immune signaling), likely reflecting noise, but the core theme is clearly chaperone-driven protein folding.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2000778","count":5},{"id":"GO:0090666","count":5},{"id":"GO:0033198","count":5},{"id":"GO:0042026","count":5},{"id":"GO:0051131","count":5}]},{"hash":"2013632252160829548","title":"Post-transcriptional RNA processing and translation control","description":"This cluster centers on RNA processing and post-transcriptional regulation of gene expression, including mRNA capping, nonsense-mediated decay, and miRNA/siRNA processing, as well as regulation of translational initiation. The GO terms collectively point to mRNA maturation and control of translation, with a minor association to cell proliferation that may reflect broader cellular growth contexts.","confidence":"High","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":2},{"id":"GO:0000184","count":2},{"id":"GO:0008283","count":2},{"id":"GO:1905612","count":1},{"id":"GO:1905618","count":1}]},{"hash":"2123840267467093671","title":"DNA Replication and Centrosome Cycle","description":"The top GO terms cluster around DNA replication, centrosome cycle, and regulation of nuclear cell cycle DNA replication, pointing to a core cell-cycle/DNA synthesis function; the remaining terms (developmental and neural processes) appear ancillary to this primary theme.","confidence":"High","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007098","count":4},{"id":"GO:0010571","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0008542","count":3}]},{"hash":"1044070395359722559","title":"Neural signaling and metabolic regulation","description":"This cluster mixes neural-related GO terms (visual learning, excitatory postsynaptic potential, response to cocaine) with metabolic/endocrine terms (insulin receptor signaling, glucose metabolic process, thyroid gland development), suggesting proteins involved in brain signaling that are linked to metabolic regulation. The combination points to a neural-endocrine/metabolic theme rather than a single narrow function.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":2},{"id":"GO:0047484","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0042220","count":2}]},{"hash":"1911139824866154010","title":"Nucleocytoplasmic Transport","description":"Top terms indicate strong involvement in RNA export, snRNP import, nuclear pore assembly, and Ran signaling, all central to nucleo-cytoplasmic transport; the link to astral microtubule organization and cell division suggests coordination with mitotic processes. Despite one outlier term, the dominant theme is transport across the nuclear envelope and pore assembly.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006608","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0051031","count":2}]},{"hash":"1745186363835407508","title":"Unknown","description":"The top GO terms cover immune development, kidney development/function, skeletal muscle development, and ubiquitin-related regulation, with no single cohesive function or pathway tying them together. The lack of a unifying theme and no connecting edges suggest the cluster is not functionally cohesive. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002467","count":2},{"id":"GO:0072156","count":2},{"id":"GO:0070294","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0042787","count":2}]},{"hash":"1171478305172406302","title":"Unknown","description":"The top terms are scattered across temperature response, nervous system development and pain, chromatin-related transcription regulation, plasminogen activation, and cell migration, with no single coherent function linking the proteins. With no interactions among members, a meaningful, specific label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0048484","count":2}]},{"hash":"145765204157311215","title":"Immune signaling and vesicle trafficking","description":"Several top GO terms point to immune regulation (positive regulation of Th1 cell differentiation; neutrophil clearance and neutrophil apoptotic regulation) and secretory/trafficking processes (positive regulation of vesicle fusion, calcium ion transmembrane transport) and cell interactions (cell-cell adhesion). Although a couple of terms pertain to development in pancreas or sperm motility, the majority highlight signaling and vesicle-mediated control of immune responses and cell communication, suggesting this cluster represents immune signaling with vesicle dynamics.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045627","count":1},{"id":"GO:0031340","count":1},{"id":"GO:0097350","count":1},{"id":"GO:0033031","count":1},{"id":"GO:1901317","count":1}]},{"hash":"2287825360519749433","title":"Ion Transport and Signaling Modulation","description":"The top GO terms point to multiple ion transport processes (zinc, calcium, sodium, copper) as well as regulation of signaling pathways (PKA activity, NOS activity, glucocorticoid biosynthesis). Although a few terms touch on lipid signaling and stress responses, the recurring theme is ion transport paired with modulation of cellular signaling. This name captures both the transport and the signaling-regulatory aspects suggested by the cluster.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071577","count":1},{"id":"GO:1903515","count":1},{"id":"GO:0046839","count":1},{"id":"GO:0002028","count":1},{"id":"GO:0060003","count":1}]},{"hash":"886503244143745546","title":"Unknown","description":"The top GO terms are diverse, spanning RNA splicing, translation initiation, ubiquitin-dependent protein degradation and proteasome assembly, plus development-related and extracellular matrix/adhesion processes. This mix does not point to a single cohesive biological function or pathway for the cluster, so a specific, representative label is not justifiable.","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002291","count":2},{"id":"GO:0035987","count":2}]},{"hash":"667250356313254377","title":"Membrane Transport and Ion Homeostasis","description":"This cluster is driven by GO terms for transmembrane transport of ions and metabolites (e.g., potassium, branched-chain amino acids, vitamins, thiamine, glutathione into vacuole, cadmium into vacuole) and related membrane potential regulation, with cytochrome complex assembly as a secondary signal. A few terms appear unrelated (e.g., sperm capacitation, cholesterol absorption), but the dominant theme is membrane transport and ion homeostasis.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017004","count":2},{"id":"GO:0071805","count":1},{"id":"GO:0048240","count":1},{"id":"GO:0015803","count":1},{"id":"GO:0035461","count":1}]},{"hash":"1540848618915563420","title":"Presynaptic vesicle exocytosis and neurotransmission","description":"The cluster is enriched for GO terms about exocytosis of dense core granules and synaptic vesicles, regulation of presynaptic release, and GABAergic synaptic transmission, suggesting a cohesive role in presynaptic neurotransmitter release and synaptic signaling. Some terms (ergosterol biosynthesis, abscisic acid signaling) appear tangential, possibly due to annotation noise, but the core theme centers on presynaptic exocytosis and neurotransmission.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:1905415","count":3},{"id":"GO:0032443","count":3},{"id":"GO:0061511","count":3},{"id":"GO:0046456","count":3},{"id":"GO:2000300","count":3}]},{"hash":"865700023200681498","title":"RNA Methylation and Capping","description":"The top GO terms cluster around RNA modification by methylation across tRNA, rRNA, peptide residues, and mRNA cap methylation, suggesting a shared role as RNA methyltransferases or methylation-associated factors. While a couple of biosynthetic or stress-response terms appear, the dominant theme is RNA methylation, indicating a cohesive function for this protein set.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0018027","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0018364","count":2},{"id":"GO:0036265","count":2}]},{"hash":"1012557690698139811","title":"Vesicle trafficking and microtubule dynamics","description":"The top GO terms cluster around ER-to-Golgi vesicle transport, microtubule severing, and cilium assembly, all tied to intracellular trafficking and cytoskeletal remodeling; the cell division term also fits within this cytoskeletal/trafficking context. Some nuclear-related terms may reflect multifunctional proteins or annotation spillover, but the dominant theme appears to be vesicle transport coupled with microtubule dynamics. ","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0051260","count":2}]},{"hash":"1656550955862769089","title":"Unknown","description":"The GO terms across these proteins are scattered across immune differentiation, hormonal and UV/stress responses, development, and chromatin modification, with no shared process and no edges linking proteins. There is no coherent functional theme to label a specific cluster, so Unknown with None.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010742","count":1},{"id":"GO:0043923","count":1},{"id":"GO:0090043","count":1},{"id":"GO:0009751","count":1},{"id":"GO:0009555","count":1}]},{"hash":"996400134473388477","title":"Neuronal Synaptic Signaling and Plasticity","description":"The cluster centers on neural communication and activity-dependent regulation, with GO terms for regulation of neuronal synaptic plasticity, excitatory postsynaptic potential, and postsynaptic calcium signaling. The presence of positive regulation of calcineurin-NFAT signaling and adenylate cyclase activation supports Ca2+/cAMP\u2013dependent modulation of synaptic strength. While a couple of terms touch on astrocyte differentiation and photoreceptor morphogenesis (peripheral to neurons), the dominant signal is neural synaptic signaling and plasticity, making this a coherent label.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048168","count":2},{"id":"GO:0032972","count":1},{"id":"GO:0042994","count":1},{"id":"GO:0014898","count":1},{"id":"GO:0048708","count":1}]},{"hash":"1120122384758201136","title":"Multitissue Developmental Regulation","description":"This cluster features GO terms tied to developmental processes across multiple tissues (otoc vesicle formation, astrocyte differentiation, photoreceptor morphogenesis, muscle-related development) and broad regulatory functions (negative regulation of kinase activity, negative regulation of sumoylation, regulation of DNA binding). The common theme appears to be regulatory proteins that influence differentiation and morphogenesis in diverse tissues, rather than a single, unified pathway. Therefore, a concise label is \u201cMultitissue Developmental Regulation.\u201d","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0033234","count":4},{"id":"GO:0030916","count":4},{"id":"GO:0043388","count":4},{"id":"GO:0014718","count":4}]},{"hash":"1469660408882343547","title":"N-terminal methionine acetylation","description":"The top GO term GO:0017196 \u2014 N-terminal peptidyl-methionine acetylation \u2014 is the only annotation, suggesting the proteins cluster around N-terminal acetyltransferase activity; with five proteins and limited functional data, the label captures the likely theme but confidence is limited.","confidence":"Low","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0017196","count":1}]},{"hash":"2091043255966276926","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045041","count":2},{"id":"GO:0032543","count":1},{"id":"GO:0022417","count":1},{"id":"GO:0051084","count":1},{"id":"GO:0033617","count":1}]},{"hash":"1831130871706946754","title":"Unknown","description":"The GO terms mix DNA replication/repair and chromosomal localization with microtubule dynamics and even membrane transport, without a clear, single functional theme. Because there isn\u2019t a cohesive biological process tying these terms together for this cluster, a specific, intuitive label isn\u2019t supported.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044861","count":1},{"id":"GO:0031116","count":1},{"id":"GO:0001578","count":1},{"id":"GO:0000012","count":1},{"id":"GO:0006271","count":1}]},{"hash":"2145489084112565121","title":"ERAD/Ubiquitin Regulation","description":"The top GO terms are centered on ubiquitin-related ER-associated degradation (ERAD) and its regulation (including negative regulation of ERAD and of K48-linked deubiquitination). Other terms appear sporadic, suggesting incidental annotations, so the core theme is ERAD/ubiquitin regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0031134","count":1},{"id":"GO:0002814","count":1},{"id":"GO:1903094","count":1},{"id":"GO:0008219","count":1}]},{"hash":"812670103986139893","title":"Unknown","description":"The GO terms in this cluster are highly diverse with no single shared biological process. While there are a few entries related to DNA damage response (gamma radiation, double-strand break repair, telomere maintenance), the majority point to unrelated areas such as brain development and smooth muscle proliferation, and there are no edges to suggest a coherent functional module. This makes a confident, specific label unlikely.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051290","count":1},{"id":"GO:1904430","count":1},{"id":"GO:0071480","count":1},{"id":"GO:0071475","count":1},{"id":"GO:0032508","count":1}]},{"hash":"2173943904103390973","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000724","count":2},{"id":"GO:0048568","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0000480","count":2}]},{"hash":"1672886383314081844","title":"Actin Cytoskeleton and Cell Polarity","description":"The cluster is dominated by actin- and cytoskeleton-related terms (actin filament bundle distribution, muscle filament sliding, establishment/maintenance of cell polarity regulating cell shape) and cell motility (cell gliding), indicating a primary theme of actin-driven shape and movement. Peripheral terms like hypoxia response and T cell immunity appear less central to the core function.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":2},{"id":"GO:0071976","count":1},{"id":"GO:0002456","count":1},{"id":"GO:0045033","count":1},{"id":"GO:0030049","count":1}]},{"hash":"427191205505998388","title":"Ribosome biogenesis and translation","description":"The strongest signals are translation and ribosomal large subunit assembly/biogenesis, with several preribosome-associated terms, pointing to a cluster of ribosome production and protein synthesis machinery; a few cell cycle and retinal-related terms are present but far less frequent, likely incidental.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0000027","count":3},{"id":"GO:0060041","count":1},{"id":"GO:0007093","count":1},{"id":"GO:0031290","count":1}]},{"hash":"418375517494716993","title":"Endosome Trafficking and Centrosome Localization","description":"The terms cluster around intracellular transport, notably endosome-to-lysosome and endosome-to-Golgi trafficking, along with protein localization to the centrosome and regulation of GTPase activity, suggesting a membrane trafficking/organellar localization theme. Some annotations (ascospore membrane formation, brood size, auxin homeostasis) appear unrelated and may reflect noise, so the core signal is moderate.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904179","count":1},{"id":"GO:0071539","count":1},{"id":"GO:0032120","count":1},{"id":"GO:0008333","count":1},{"id":"GO:0034498","count":1}]},{"hash":"74925794650511682","title":"Translational control and mRNA turnover","description":"Most terms cluster around translation and cytoplasmic translation, with support for regulation of translation and mRNA decay (deadenylation-dependent decay). While there are a few outliers referencing necroptosis or carbohydrate metabolism, the dominant signals point to a shared function in protein synthesis control and post-transcriptional regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0070266","count":1},{"id":"GO:0030980","count":1},{"id":"GO:0006015","count":1},{"id":"GO:0005980","count":1}]},{"hash":"2259524844450127512","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070512","count":1},{"id":"GO:0036205","count":1},{"id":"GO:1903721","count":1},{"id":"GO:0006295","count":1},{"id":"GO:0042769","count":1}]},{"hash":"1037625834846392830","title":"Insect development and oogenesis","description":"This cluster centers on developmental processes and differentiation in insects, with terms like vitellogenesis (egg yolk formation), segmentation identity, and morphogenesis, suggesting roles in embryonic development and reproductive biology. While there are broader terms like transcription and ER stress response, the strongest signals are insect-specific developmental and oogenic processes, supporting a label around insect development and oogenesis rather than a single, narrow pathway.","confidence":"Medium","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050873","count":2},{"id":"GO:0035470","count":2},{"id":"GO:0007296","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0003151","count":1}]},{"hash":"1558317232341400011","title":"Chromatin and cell-cycle regulation","description":"The terms cluster around chromatin organization, nuclear localization, and mitotic spindle assembly, suggesting a core theme of nuclear regulation and cell division. Additional terms reference translation initiation, ubiquitination, and vesicle transport, which may be ancillary to this central function. Given the mix, a label focusing on nuclear processes and chromatin dynamics best captures the main signal.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0070262","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0060271","count":1}]},{"hash":"1679822953978082730","title":"Actin-myosin and mitotic cytoskeleton dynamics","description":"This cluster centers on actin-mene with multiple GO terms related to actin filament regulation, actomyosin contractile ring assembly, muscle contraction, and mitotic spindle assembly, indicating a shared theme of cytoskeletal remodeling that governs both contraction in muscle and cytoskeletal processes during cell division. The combination of muscle development/contraction terms with mitotic cytoskeletal terms supports this cohesive interpretation, though some items pertain to broader signaling or junction localization, so I assign a Medium confidence.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086097","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0055013","count":2},{"id":"GO:0014728","count":2},{"id":"GO:1902405","count":2}]},{"hash":"1241569645989374499","title":"Immune Signaling and Chromatin Regulation","description":"The top GO terms cluster around adaptive and innate immune signaling (adaptive immune response, V(D)J recombination, NF-kB pathway regulation) with accompanying chromatin-related terms (histone methylation, histone catabolic processes) and antiviral transport regulation, suggesting a group focused on immune function with transcriptional regulation. A few terms (bud neck, X inactivation) seem less directly connected, indicating some noise, but the dominant theme is immune signaling and chromatin modulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0039536","count":2},{"id":"GO:0070512","count":1},{"id":"GO:0036205","count":1},{"id":"GO:1903721","count":1}]},{"hash":"849203096376309460","title":"Membrane Biogenesis and Energy Metabolism","description":"The top GO terms point to membrane-related processes (GPI anchor biosynthesis, rhabdomere membrane biogenesis) and energy-transducing activities (mitochondrial electron transport, ATP synthesis, and photosynthesis-related light reactions), suggesting proteins linked to membrane assembly and energy production across organelles. The presence of an older, obsolete term set implies annotation noise, but the underlying theme of membrane biogenesis combined with organelle energy metabolism fits a coherent cluster label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0019684","count":2},{"id":"GO:0042773","count":1},{"id":"GO:0030004","count":1}]},{"hash":"561483237060775615","title":"SCF-Dependent Ubiquitination and Proteasomal Degradation","description":"The cluster centers on ubiquitin-mediated protein turnover, especially SCF E3 ligase activity linking ubiquitination to proteasomal degradation. This is supported by GO terms for SCF-dependent proteasomal degradation, various ubiquitin linkages (including K11), histone ubiquitination, and cell-cycle transitions (G2/M, mitotic cycle). Some plant-development terms (photomorphogenesis, flowering) suggest broader roles in development, but the core theme remains ubiquitin-dependent degradation regulating the cell cycle.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":4},{"id":"GO:0000086","count":4},{"id":"GO:0035518","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0000278","count":3}]},{"hash":"898517280603871743","title":"Endocytosis-Linked Signaling","description":"This cluster features GO terms for clathrin-dependent endocytosis, small GTPase-mediated signal transduction, insulin receptor signaling, and responses to cytokines/stress signaling. Together they suggest a theme of intracellular trafficking coupled with signal transduction. Some terms (germ cell development, myelin maintenance) are less clearly tied to this theme, likely reflecting annotation breadth or pleiotropy.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007281","count":3},{"id":"GO:0072583","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0032287","count":3},{"id":"GO:0008286","count":3}]},{"hash":"52603739643948956","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":2},{"id":"GO:0070262","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006890","count":2}]},{"hash":"1559611782750692973","title":"Unknown","description":"The top GO terms span redox homeostasis, DNA repair, RNA stability, corneocyte development, aging, lipid signaling, and metabolism, with no clear unifying function or pathway. The cluster also shows limited connectivity (edges 2, triangles 0), supporting the absence of a cohesive theme to name a specific function. ","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0043488","count":2}]},{"hash":"1838919533936491256","title":"Adaptive immunity and angiogenic signaling","description":"This cluster centers on adaptive immune response and angiogenesis, with supporting signals in ERK cascade regulation, small GTPase pathways, and endocytosis. The presence of dendritic cell\u2013related apoptotic regulation, fungal-origin responses, and beta selection points to immune cell activation and maturation, while endothelial migration and angiogenesis terms connect to vascular remodeling. Altogether, the proteins likely participate in immune signaling that interfaces with vascular/endocytic processes.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0071226","count":4},{"id":"GO:0043536","count":4}]},{"hash":"378274020837913046","title":"Embryonic organ development","description":"The top GO terms point to broad developmental roles across multiple organs (heart, bone, kidney) and tissue organization, with additional regulatory processes affecting signaling and cell interactions. This pattern suggests a cluster of proteins involved in embryonic organogenesis and tissue patterning rather than a single specific pathway.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0030948","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0072221","count":2}]},{"hash":"669770624277469885","title":"Meiosis and Gametogenesis","description":"The Top Terms overwhelmingly center on meiotic processes and gamete development, including spermatogenesis, oocyte development, synaptonemal complex assembly, and metaphase chromosome alignment. A few terms (e.g., mRNA stabilization, nonassociative learning, GABA secretion) are less central but do not override the meiotic theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048255","count":2},{"id":"GO:0007283","count":1},{"id":"GO:0007130","count":1},{"id":"GO:0051310","count":1},{"id":"GO:0048599","count":1}]},{"hash":"748871351364685879","title":"Neuronal Axon Guidance and Adhesion","description":"The top GO terms cluster around neuronal development: axonogenesis, motor neuron axon fasciculation, dendrite self-avoidance, and homophilic cell-cell adhesion, indicating roles in axon pathfinding and neuronal wiring. Some terms reference broader signaling or unrelated processes, but the dominant signal points to neuronal connectivity and adhesion.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":2},{"id":"GO:1902955","count":2},{"id":"GO:1905240","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0050772","count":2}]},{"hash":"1035176222410976486","title":"Nociception and Pain Response Signaling","description":"The cluster is dominated by GO terms related to sensing and responding to painful stimuli: detection of chemical, temperature, and mechanical stimuli involved in nociception, along with an explicit \"response to pain.\" Additional terms about calcium signaling and PKA regulation may reflect common signaling pathways in pain neurons, but the pain detection/response theme is clear and representative. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000480","count":3},{"id":"GO:0034638","count":3},{"id":"GO:0050968","count":2},{"id":"GO:0071651","count":2},{"id":"GO:0098703","count":2}]},{"hash":"1276741557374637361","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046825","count":2},{"id":"GO:0031648","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0070389","count":1}]},{"hash":"272835666487708615","title":"Epidermal Development and Cell Cycle Regulation","description":"The terms cluster around regulation of epidermal cell growth, division, and proliferation, plus cytoskeletal and cell\u2013cell junction processes (adherens junction assembly and pseudopodium dynamics) that shape epithelial tissues. Additional terms reference placode- and papilla-formation in skin/sensory contexts, supporting a theme of developmental regulation of epidermal structure and growth; a few items fall into broader developmental processes, but the core signal is epidermal development and cell-cycle control.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":3},{"id":"GO:0010482","count":2},{"id":"GO:0000011","count":2},{"id":"GO:0061198","count":2},{"id":"GO:0031274","count":2}]},{"hash":"1113512682291489331","title":"Embryonic neural and endocrine organogenesis","description":"This cluster shows a convergence of GO terms related to embryonic development across neural tissues (forebrain, retina, spinal cord, neuronal differentiation, forebrain\u2013midbrain boundary) and endocrine organs (pituitary, thyroid, pancreas) plus other organ morphogenesis processes (cranial skeleton, ureteric bud morphogenesis). The unifying theme is embryonic organogenesis with a focus on neural and endocrine tissue specification and formation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021798","count":5},{"id":"GO:0030878","count":5},{"id":"GO:0060041","count":5},{"id":"GO:0021527","count":5},{"id":"GO:0021902","count":5}]},{"hash":"1927099305518261747","title":"Unknown","description":"The terms span redox homeostasis, DNA repair, mRNA stability regulation, corneocyte development, aging, lipid signaling, and more, showing no single cohesive function or pathway for this small cluster. With sparse connectivity and diverse annotations, a unified label isn\u2019t justifiable.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0043488","count":2}]},{"hash":"25393580190792124","title":"Nucleotide and CoA Biosynthesis","description":"The proteins in this cluster are annotated with multiple nucleotide metabolism terms (ADP biosynthesis, purine ribonucleotide interconversion, nucleoside monophosphate phosphorylation, ITP metabolism, AMP salvage, CDP biosynthesis) and coenzyme A biosynthetic process, indicating a core function in nucleotide and cofactor biosynthesis. Development terms (brain and liver development) may reflect broader or tissue-specific annotations rather than a core function of the cluster. Therefore, a label focused on nucleotide and cofactor biosynthesis is most representative.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006172","count":4},{"id":"GO:0015951","count":4},{"id":"GO:0046940","count":4},{"id":"GO:0046041","count":4},{"id":"GO:0007420","count":4}]},{"hash":"979510536915688923","title":"Unknown","description":"There are 5 proteins with no shared GO terms, no edges or triangles, and no top terms reported. The ReCIPE note mentioning 20 proteins re-added with degree 0.75 does not align with any connected cluster here, so there is no evident functional theme to label. Without enrichment or interaction data, a specific functional label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1123879392695119480","title":"Unknown","description":"The terms span proteoglycan biosynthesis, plasminogen activation, lipid metabolism, leptin signaling, immune response, and development signaling, with no shared edge or obvious common pathway. This heterogeneity makes it inappropriate to assign a specific functional label; thus Unknown is the safest descriptor.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030210","count":1},{"id":"GO:0031639","count":1},{"id":"GO:0051005","count":1},{"id":"GO:0070328","count":1},{"id":"GO:0044320","count":1}]},{"hash":"1229632050516396582","title":"Synaptic signaling and plasticity","description":"Dominant terms point to neuronal signaling, with excitatory postsynaptic potential and regulation of postsynaptic calcium highlighting core synaptic activity. The cocaine response term supports drug-induced neuronal plasticity, while cell adhesion and signaling regulation align with synaptic formation and modulation. A few terms are broader (chromatin regulation, EMT) but can be related to developmental and plasticity contexts, keeping the overall theme tightly focused on synaptic function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0070262","count":1},{"id":"GO:0014898","count":1},{"id":"GO:0098609","count":1}]},{"hash":"770256462874554782","title":"Embryonic development and organ morphogenesis","description":"These GO terms cluster around broad developmental processes and organogenesis across multiple tissues (cartilage, placenta/embryo, heart cushion EMT, spleen, pancreas, roof of mouth) and include patterning and transcriptional regulation during development. The shared theme is embryonic development and tissue morphogenesis rather than a single pathway, leading to a concise developmental cluster label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0003323","count":3}]},{"hash":"337355446740978374","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010606","count":1},{"id":"GO:0000467","count":1},{"id":"GO:0034415","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0006261","count":1}]},{"hash":"369747821216654997","title":"Membrane Ion and Water Transport","description":"Top GO terms indicate transport across membranes for multiple ions (nitrate, chloride, potassium, protons, monoatomic anions, iron) and transepithelial water transport, plus regulation of cell volume and pH response. Together these point to a core function in ion homeostasis and water movement across membranes, consistent with transporter or channel activity, often seen in epithelial tissues. The single tissue-differentiation term (salivary gland development) is peripheral to the main transport theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":1},{"id":"GO:1902476","count":1},{"id":"GO:0035377","count":1},{"id":"GO:0010447","count":1},{"id":"GO:0060689","count":1}]},{"hash":"2259007528493547570","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0045085","count":1},{"id":"GO:0045787","count":1},{"id":"GO:0061470","count":1}]},{"hash":"46593098452134114","title":"Retina Development and Visual Perception","description":"The top GO terms point to eye- and retina-specific processes (retina vasculature development, visual perception, endosome to melanosome transport) plus related neural development (microglia development, Notch signaling) and junction assembly, suggesting a cohesive theme around retina development and visual system biology.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0007601","count":1}]},{"hash":"2079245946947623706","title":"Endothelial angiogenesis via GTPases","description":"The Top Terms emphasize endothelial tube lumen extension, regulation of blood vessel remodeling, and sprouting angiogenesis through small GTPase\u2013mediated signaling and positive regulation of GTPase activity, indicating a theme of endothelial cell migration and tube formation governed by Rho/Rac/Cdc42 pathways. Additional terms related to ER stress and extrinsic apoptotic signaling suggest linked stress and inflammatory responses in vascular contexts, which can modulate angiogenesis. Together these points support a cohesive cluster centered on endothelial morphogenesis driven by GTPase signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900103","count":1},{"id":"GO:0008625","count":1},{"id":"GO:0021816","count":1},{"id":"GO:0060313","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1024209539224696027","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007026","count":2},{"id":"GO:0061158","count":1},{"id":"GO:0031664","count":1},{"id":"GO:0060544","count":1},{"id":"GO:0070512","count":1}]},{"hash":"498848078251791584","title":"RNA processing and translation regulation","description":"This cluster shows a cohesive theme of post-transcriptional gene expression control, with GO terms focusing on translation initiation and regulation (e.g., initiation complex assembly, IRES-dependent translation, general regulation of translational initiation), as well as mRNA processing and export steps (splicing site recognition, mRNA export, poly(A) tail regulation) and miRNA-mediated translational silencing. These together indicate a module of proteins involved in RNA maturation and control of protein production from mRNA.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0097010","count":4},{"id":"GO:1902625","count":4},{"id":"GO:0075522","count":4},{"id":"GO:1903586","count":4},{"id":"GO:0060211","count":4}]},{"hash":"1519720671825909056","title":"Unknown","description":"Top terms span aging, cardiovascular regulation, calcium signaling, histamine secretion, and various immune/erythrocyte processes, plus trophectoderm differentiation. The functions are highly diverse with no clear shared theme, and there are no internal connections, so a cohesive label isn\u2019t supported.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":2},{"id":"GO:0045987","count":2},{"id":"GO:0002906","count":1},{"id":"GO:0010460","count":1},{"id":"GO:0050850","count":1}]},{"hash":"1819617900247354025","title":"Developmental transcriptional regulation","description":"The top GO terms point to regulation and fidelity of transcription (negative regulation of transcription by RNA polymerase II, transcription elongation fidelity by RNA polymerase III), suggesting a core role in controlling gene expression. The concurrent developmental terms (glial/oligodendrocyte differentiation, trachea cartilage development, embryonic digestive tract morphogenesis, gallbladder development) imply processes governed by transcriptional control across diverse tissues, rather than a single tissue-specific pathway. This combination supports labeling the cluster as transcriptional regulation involved in development, rather than a narrow, tissue-specific function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0060534","count":2},{"id":"GO:0014009","count":2},{"id":"GO:0048557","count":2},{"id":"GO:0010197","count":2}]},{"hash":"1559880385100941644","title":"Synapse Organization and Receptor Recycling","description":"This cluster is best characterized by terms related to neural synapse architecture and receptor handling, notably synapse organization and regulation of receptor recycling, which suggest a shared role in synaptic structure and trafficking. Other GO terms present (xenobiotic response, retina development, cholesterol metabolism) appear more peripheral or noisy (including obsolete terms), so the strongest common thread is neuronal synapse organization and receptor recycling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0019441","count":1},{"id":"GO:0008285","count":1},{"id":"GO:0001919","count":1},{"id":"GO:0050808","count":1}]},{"hash":"1589757975486872369","title":"Eye development and visual perception","description":"The top GO terms cluster around eye/visual system functions, notably retina vasculature development in camera-type eye and visual perception. Additional terms touch on pigment cell transport (endosome to melanosome) and neural/junctional aspects that can be relevant to ocular tissues, supporting a theme of eye development and function. However, the set is small and contains some unrelated terms, so the label is best described as representative but with only moderate confidence.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0007601","count":1}]},{"hash":"1310864680313924292","title":"Unknown","description":"The top GO terms span very disparate biology (copper homeostasis, snoRNP assembly, chaperone refolding, histone methylation, cytokinin signaling, photosynthesis, ER-stress translation, cilium assembly, prostate development) with only single-term annotations and no shared function across the cluster. The lack of edges and presence of obsolete terms suggest this set does not form a coherent functional module, so no clear label can be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006878","count":1},{"id":"GO:0006825","count":1},{"id":"GO:0000492","count":1},{"id":"GO:0070389","count":1},{"id":"GO:0061087","count":1}]},{"hash":"1597269469279458364","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006295","count":1},{"id":"GO:0072429","count":1},{"id":"GO:0010520","count":1},{"id":"GO:0061819","count":1},{"id":"GO:0000736","count":1}]},{"hash":"1051522009373444250","title":"RNA processing and translation initiation","description":"The terms cluster around RNA maturation steps (mRNA polyadenylation, splicing, tail shortening) and initiation of translation (eIF4F complex assembly, translational initiation, IRES-dependent viral translation), with some stress-responsive regulation of mRNA stability. This points to a coherent RNA-processing and translation-control theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0097010","count":1},{"id":"GO:0000244","count":1}]},{"hash":"866397204175639702","title":"Neuronal Migration and Synaptic Localization","description":"The GO terms converge on neuronal development, including ventral spinal cord and cortical neuron migration, lamination, and reelin signaling, along with synapse localization and AMPA receptor activity, indicating a cluster of proteins involved in neuronal placement and synaptic targeting.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":1},{"id":"GO:0021517","count":1},{"id":"GO:0097120","count":1},{"id":"GO:2000969","count":1},{"id":"GO:0097477","count":1}]},{"hash":"1341653678587494480","title":"Developmental differentiation signaling","description":"The terms cluster around a receptor guanylyl cyclase signaling pathway and a range of developmental/differentiation processes (germline and embryonic development, hematopoietic-like differentiation, and muscle development), suggesting a general role in developmental signaling that influences multiple lineages rather than a single specific function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007168","count":2},{"id":"GO:0030713","count":1},{"id":"GO:0048706","count":1},{"id":"GO:0030851","count":1},{"id":"GO:0035190","count":1}]},{"hash":"1249016297173411969","title":"Neural development and synaptic signaling","description":"Top GO terms indicate neuronal signaling and development: excitatory postsynaptic potential, long-term synaptic potentiation, axonogenesis, visual perception, and Schwann cell development. Other terms related to cell cycle and apoptosis appear less central, so the core theme is neural development and synaptic function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0010800","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0009738","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1997637660513297948","title":"Unknown","description":"The top terms are highly diverse, including thrombocyte differentiation, tarsal gland development, foam cell differentiation, host-mediated activation of viral transcription, and chromatin-related processes (nucleosome disassembly, heterochromatin boundary formation) as well as transcription initiation and tubulin deacetylation regulation. With only four proteins connected by a single edge and no clear shared function, there isn't a coherent biological theme tying the cluster together, so no reliable specific label can be assigned.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002574","count":1},{"id":"GO:0033696","count":1},{"id":"GO:0006367","count":1},{"id":"GO:1903699","count":1},{"id":"GO:0010742","count":1}]},{"hash":"894742844419837881","title":"Neural signaling and metabolism","description":"The top GO terms include neural functions like visual learning, excitatory postsynaptic potential, and response to cocaine, alongside metabolic/endocrine terms such as insulin receptor signaling and glucose metabolism, with thyroid development also pointing to endocrine processes. This suggests a broad neural-endocrine/metabolic theme, but the terms are diverse and not tightly cohesive, so the label is a best-effort summary rather than a precise function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":4},{"id":"GO:0047484","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0042220","count":4}]},{"hash":"690259895540863667","title":"Neuronal signaling and actin remodeling","description":"The GO terms point to growth-factor signaling (IGF/insulin receptor pathway), small GTPase\u2013mediated signaling, and caveolin-dependent endocytosis, paired with actin cytoskeleton dynamics (actin patch and filament bundle assembly) and neuronal maintenance processes (dendritic spine maintenance, PNS myelin maintenance). Together, they suggest a theme of signaling pathways that regulate cytoskeletal organization and membrane trafficking in neurons. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001286","count":1},{"id":"GO:1990314","count":1},{"id":"GO:0000147","count":1},{"id":"GO:0007264","count":1},{"id":"GO:0032287","count":1}]},{"hash":"828694504920443999","title":"Ribosome biogenesis and translation","description":"Based on the prominent GO terms, the cluster centers on ribosome-related processes: translation, ribosomal large subunit assembly/biogenesis, and related post-translational targeting steps, with some ancillary protein stability and ubiquitin-mediated regulation likely reflecting quality control of translation machinery.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006605","count":2},{"id":"GO:0000027","count":1},{"id":"GO:2000435","count":1},{"id":"GO:1904667","count":1}]},{"hash":"2039611665612758160","title":"Developmental cell polarity and adhesion","description":"GO terms indicate roles in tissue development and remodeling (nervous/exocrine development, satellite cell migration) as well as cell architecture (polarity, adherens junctions, focal adhesions) and wound healing; exosomal secretion suggests intercellular signaling. Together, these point to a theme of developmental tissue organization and adhesion.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0035272","count":2},{"id":"GO:0090307","count":2},{"id":"GO:1902766","count":2},{"id":"GO:0035088","count":2}]},{"hash":"1199916433246115662","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0033129","count":2},{"id":"GO:0070935","count":2},{"id":"GO:0034396","count":1},{"id":"GO:0035551","count":1}]},{"hash":"24319327421098473","title":"Neural signaling and sensory learning","description":"These GO terms center on neuronal signaling and learning, featuring excitatory synaptic activity, plasticity, and various forms of sensory learning (olfactory, taste), with some lateral line development; together they suggest a cluster focused on neural communication and experience-dependent sensory adaptation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0006865","count":1},{"id":"GO:0048899","count":1},{"id":"GO:0048169","count":1}]},{"hash":"1259737520936318195","title":"Synaptic vesicle cycling and excitatory signaling","description":"Top GO terms point to neuronal synaptic function, including excitatory postsynaptic potential and regulation of vesicle exocytosis/endocytosis, with a nod to substantia nigra development. This suggests a cluster centered on synaptic vesicle trafficking and excitatory signaling in neurons, particularly in dopaminergic pathways, despite some non-specific terms present. Confidence in this label being representative is High.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0035690","count":3},{"id":"GO:1900242","count":3}]},{"hash":"605918448322792388","title":"GTPase-regulated vesicle trafficking","description":"This cluster is dominated by GO terms involving endosome-lysosome transport, endosome-to-plasma membrane trafficking, lysosomal membrane organization, and exocytosis, all of which point to regulation of vesicle trafficking and membrane dynamics. The presence of small GTPase signaling terms and GTPase activity regulation supports a theme of GTPase-driven control of trafficking, with some actin remodeling context (podosome assembly) that can intertwine with vesicle movement. Overall, the proteins appear to function as regulators of vesicle trafficking rather than core structural components.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030037","count":2},{"id":"GO:1902824","count":2},{"id":"GO:0071803","count":2},{"id":"GO:0045956","count":2},{"id":"GO:1905751","count":2}]},{"hash":"1500461029238229473","title":"Unknown","description":"This cluster has no edges and no enriched GO terms to define a shared function; with four proteins and no term signals, there is no clear theme to name.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"444348187836011160","title":"Unknown","description":"The GO terms span diverse developmental and cellular processes across multiple tissues (trachea cartilage development, oligodendrocyte differentiation, glial cell proliferation, embryonic digestive tract morphogenesis, gallbladder development) plus a few unrelated cellular activities (microtubule polymerization, polar nucleus fusion, transcriptional fidelity, apoptotic signaling). With no connecting pathway or cohesive function and no edges, there is no single representative label for the cluster. Therefore, Unknown with None.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031116","count":1},{"id":"GO:0060534","count":1},{"id":"GO:0014009","count":1},{"id":"GO:0048557","count":1},{"id":"GO:0010197","count":1}]},{"hash":"1391663728099120275","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0036494","count":1}]},{"hash":"485564673557821728","title":"Embryonic tissue development and hormone signaling regulation","description":"This cluster includes GO terms spanning neural development (retina, GABAergic interneuron differentiation, brain boundary morphogenesis), heart formation, osteoblast differentiation regulation, hair cycle control, stomach neuroendocrine differentiation, and responses to estrogen/androgen signaling. The common thread appears to be regulation of developmental differentiation across multiple tissues, with a notable influence from hormonal signaling pathways, rather than a single tissue-specific process. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045668","count":4},{"id":"GO:0060766","count":4},{"id":"GO:0021555","count":3},{"id":"GO:0003407","count":3},{"id":"GO:0021892","count":3}]},{"hash":"1673238931564232560","title":"Insulin/IGF Signaling and Actin Dynamics","description":"These proteins cluster around signaling pathways involving insulin receptor signaling and IGF stimulus response, along with caveolin-mediated endocytosis regulation and actin cytoskeleton remodeling via small GTPases. The combination suggests a module where membrane trafficking and signal transduction interface with cytoskeletal dynamics, with some neurological context hinted by myelin maintenance and grooming behavior terms.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2001286","count":1},{"id":"GO:1990314","count":1},{"id":"GO:0000147","count":1},{"id":"GO:0007264","count":1},{"id":"GO:0032287","count":1}]},{"hash":"2175694649497373016","title":"Neural Sensory Signaling and Learning","description":"This cluster centers on GO terms related to sensory perception and neural function (detection of chemical stimuli, potassium and amino acid transport for neuronal activity, learning and synaptic plasticity) as well as ethanol-associated behaviors (conditioned taste aversion, behavioral response to ethanol). While a few terms pertain to development or nucleolar processes, the dominant theme is neural sensory signaling and learning, justifying this label.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007000","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0050907","count":1},{"id":"GO:0010157","count":1},{"id":"GO:0008542","count":1}]},{"hash":"2268257801570026293","title":"Neuronal excitability and pain signaling","description":"The top GO terms cluster around neuronal activity: action potential generation, ion (sodium, calcium) transport, and membrane depolarization in neurons, including Purkinje cells, along with pain perception. While a couple of terms touch on unrelated processes (autophagy, mRNA export), the dominant theme among the terms is neuronal signaling and excitability, justifying the label.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0019228","count":1},{"id":"GO:0007259","count":1}]},{"hash":"405832049634125724","title":"Unknown","description":"The GO terms are highly diverse, spanning hair orientation, vascular maturation, neural and glial development, immune differentiation, sensory perception, lipid signaling, and more. With only a single edge and no common pathway tying these terms together, there is no clear unifying function for this cluster, so a generic Unknown label is appropriate.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045317","count":2},{"id":"GO:0048105","count":2},{"id":"GO:0001955","count":2},{"id":"GO:0051796","count":2},{"id":"GO:0002315","count":2}]},{"hash":"536814071509669499","title":"Fungal morphogenesis and secretion","description":"This cluster centers on fungal-like growth responses (pseudohyphal and invasive growth under nutrient stress) alongside GO terms tied to secretory pathway and trafficking to the cell surface (protein exit from ER, localization to cell surface, secretion of lysosomal enzymes), suggesting a theme of morphological adaptation coupled with active protein secretion. The outlier term on immune signaling is less connected to the core themes but does not override the strongest signal. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000010","count":1},{"id":"GO:0007124","count":1},{"id":"GO:0001403","count":1},{"id":"GO:0070863","count":1},{"id":"GO:0033299","count":1}]},{"hash":"1059183510805241953","title":"Translation regulation and RNA processing","description":"The four proteins map to GO terms focused on translation initiation (eIF4F complex assembly, regulation of translational initiation, IRES-dependent translation) and on RNA processing steps (mRNA splice site recognition, mRNA export, poly(A) tail regulation). This suggests a cohesive role in post-transcriptional control of gene expression, spanning initiation of translation and RNA maturation/export.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097010","count":2},{"id":"GO:1902625","count":2},{"id":"GO:0075522","count":2},{"id":"GO:1903586","count":2},{"id":"GO:0060211","count":2}]},{"hash":"1307038998215348003","title":"Unknown","description":"The GO terms are highly diverse and largely unrelated (transcription regulation, iron-sulfur cluster assembly, protein maturation, nitrogen fixation, visual learning, ECM/bone regulation, epithelial apoptosis), with no clear shared function or pathway linking the four proteins. This, plus the presence of an obsolete term and zero edges, suggests annotation noise or disparate origins rather than a cohesive cluster. Confidence: None","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006880","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0051604","count":1},{"id":"GO:0009399","count":1}]},{"hash":"1937319386564449161","title":"Developmental differentiation and tissue morphogenesis","description":"The GO terms cluster around cell fate specification, lineage differentiation, and morphogenetic processes across diverse tissues (tracheal system, intestinal epithelium, oenocyte/hemangioblast lineages, primitive streak). Epigenetic regulation and adhesion processes also tie into development and tissue organization, supporting a unified theme of developmental differentiation rather than metabolic activities.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045678","count":4},{"id":"GO:0090009","count":4},{"id":"GO:0060233","count":4},{"id":"GO:0070932","count":4},{"id":"GO:1904996","count":4}]},{"hash":"418510700773701612","title":"Large ribosomal subunit biogenesis and export","description":"The dominant GO terms center on maturation and assembly of the large ribosomal subunit (LSU): maturation of LSU rRNA, large subunit assembly, preribosome assembly, and export of the LSU from the nucleus. This creates a clear theme of LSU biogenesis, suggesting the cluster represents proteins involved in ribosome maturation and nuclear export. Some terms related to cilium and retina development appear as single annotations, which may reflect secondary roles or annotation noise but do not override the primary ribosome-related signal.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0000027","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0000463","count":1}]},{"hash":"1137221885252818657","title":"Unknown","description":"The GO terms span immune signaling, heart signaling, cell junction localization, epithelial polarity, barrier establishment, sensory organ organization, and neural development, showing no single cohesive function or tissue-specific theme to bind the proteins together. Therefore, a clear, specific label isn\u2019t supported.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045075","count":1},{"id":"GO:1901206","count":1},{"id":"GO:0071896","count":1},{"id":"GO:0006470","count":1},{"id":"GO:2000670","count":1}]},{"hash":"1315112534570456706","title":"Cerebellar development and neural signaling","description":"The top terms cluster around neural development and CNS signaling, notably cerebellar Purkinje cell layer formation, myelin sheath localization, and Wnt pathway regulation, suggesting a focus on cerebellar neuron development and related signaling. Some terms are peripheral (immune or behavior-related), but the dominant theme is neural development/connectivity.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000670","count":3},{"id":"GO:0021694","count":3},{"id":"GO:0008285","count":3},{"id":"GO:2000821","count":3},{"id":"GO:0030111","count":3}]},{"hash":"1649533554659897787","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0044205","count":2},{"id":"GO:0006207","count":2},{"id":"GO:0019854","count":1},{"id":"GO:0090727","count":1},{"id":"GO:0019647","count":1}]},{"hash":"2176627363796984778","title":"Mitochondrial Copper Homeostasis and Complex IV Assembly","description":"The GO terms point to mitochondrial processes: copper ion transport and homeostasis, import of proteins into the mitochondrial matrix, insertion into the inner membrane, and assembly of the respiratory chain complex IV, along with redox balance. One term about oocyte construction appears unrelated noise; overall, the cluster centers on mitochondrial function, especially copper handling and respiratory chain assembly. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007308","count":1},{"id":"GO:0006825","count":1},{"id":"GO:0008535","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0006878","count":1}]},{"hash":"180617336214757456","title":"Junction Formation and Cytoskeletal Remodeling","description":"This cluster shows GO terms centered on tight junction assembly and endothelial barrier establishment, plus terms for cytoskeletal dynamics such as filopodium regulation and small GTPase signaling. The combination suggests proteins involved in organizing cell\u2013cell junctions and remodeling the cytoskeleton and adhesion structures, with supporting trafficking and post-translational modification processes. Confidence: Medium","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":3},{"id":"GO:0032258","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0000266","count":3},{"id":"GO:0007264","count":3}]},{"hash":"1001884313028960458","title":"Mitochondrial lipid metabolism and ECM remodeling","description":"The cluster is dominated by lipid-related processes (SREBP signaling, cholesterol biosynthesis regulation, cardiolipin metabolism) and mitochondrial inheritance, suggesting a core theme of mitochondrial lipid homeostasis, with supporting signals of extracellular matrix remodeling and podocyte development that are less central to the main theme.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901585","count":3},{"id":"GO:0034141","count":3},{"id":"GO:2000049","count":3},{"id":"GO:0032933","count":3},{"id":"GO:0000001","count":3}]},{"hash":"829606357188799739","title":"Neuronal axonogenesis and dendrite patterning","description":"The proteins are enriched for neural development themes: axonogenesis, motor neuron axon fasciculation, dendrite self-avoidance, hedgehog signaling (Smoothened), and cell adhesion, pointing to roles in neural connectivity and patterning. Some terms are obsolete or peripheral, but the core cluster centers on neuronal growth and wiring.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":4},{"id":"GO:1902955","count":4},{"id":"GO:1905240","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0050772","count":4}]},{"hash":"680620867091016286","title":"Neuronal development and axon guidance","description":"This cluster shows a clear enrichment for neuronal-related processes: homophilic cell-cell adhesion, axonogenesis, axon fasciculation, dendrite self-avoidance, and Hedgehog/Smoothened signaling, all pointing to neuronal connectivity and neurite patterning. While a couple of terms are less specific or newer/obsolete, the dominant theme is neuronal development and axon guidance, suggesting these proteins function together in establishing neural circuits.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":4},{"id":"GO:1902955","count":4},{"id":"GO:1905240","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0050772","count":4}]},{"hash":"556856510834095302","title":"Angiogenesis and endothelial migration regulation","description":"This cluster\u2019s top GO terms cluster around endothelial function and vascular remodeling, including endothelial tube lumen extension, negative regulation of sprouting angiogenesis, negative regulation of blood vessel remodeling, and small GTPase-mediated signaling that drives cell movement. While a few terms touch on ER stress or insulin signaling, the dominant theme is regulation of endothelial angiogenesis and migration.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046626","count":2},{"id":"GO:1900103","count":1},{"id":"GO:0008625","count":1},{"id":"GO:0021816","count":1},{"id":"GO:0060313","count":1}]},{"hash":"991526744697354586","title":"Small GTPase Signaling and Cytoskeletal Dynamics","description":"The top GO terms point to regulation of GTPase activity and small GTPase\u2013mediated signaling, along with actin cortex assembly and dendritic spine maintenance, indicating a focus on cytoskeletal remodeling driven by GTPase pathways. Some terms about heart development or myelin maintenance may reflect broader tissue contexts rather than a shared function of the cluster; the core theme remains GTPase signaling linked to cytoskeletal dynamics. Overall, a coherent, though small, functional group centered on signaling and cytoskeletal regulation.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0007507","count":2},{"id":"GO:2001286","count":1},{"id":"GO:1990314","count":1},{"id":"GO:0000147","count":1}]},{"hash":"1494701250533903855","title":"Cell junctions and polarity in tissue remodeling","description":"This cluster centers on establishment and maintenance of cell polarity, adherens and tight junction assembly, focal adhesion regulation, and wound healing/migration, pointing to a module of epithelial junction dynamics and tissue remodeling. Some terms (e.g., spindle assembly, excitatory postsynaptic potential) are broader or peripheral, but the core signal is junctional organization and polarity.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035272","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0090307","count":3},{"id":"GO:1902766","count":3},{"id":"GO:0035088","count":3}]},{"hash":"2103542912427912372","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":2},{"id":"GO:0001568","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0070389","count":1},{"id":"GO:0071374","count":1}]},{"hash":"1312310588983414263","title":"Neuronal RNA Processing and Signaling","description":"This cluster shows strong emphasis on RNA metabolism and processing (mRNA stability, splicing, decay, mitochondrial polyadenylation) alongside regulatory roles in miRNA silencing and neuronal-related processes (forebrain pallium proliferation, neuronal activity), suggesting a group of proteins linked to RNA regulation with neural function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":4},{"id":"GO:2000637","count":3},{"id":"GO:0006402","count":3},{"id":"GO:0097222","count":3},{"id":"GO:0022013","count":3}]},{"hash":"154360138959204146","title":"Cdc42-Driven Actin Dynamics and Cell Polarity","description":"Top terms cluster around actin cytoskeleton remodeling (actin polymerization, pseudopodium assembly, dendritic spine morphogenesis), Cdc42 signaling, and establishment/maintenance of cell polarity, suggesting the proteins function in coordinated cytoskeletal dynamics and polarity control. While a few terms (e.g., sperm capacitation, sterol import) are less connected, the dominant theme is actin-mediated structure and polarity regulation.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":1},{"id":"GO:0006468","count":1},{"id":"GO:0000011","count":1},{"id":"GO:0032488","count":1},{"id":"GO:0031274","count":1}]},{"hash":"73949283428925450","title":"Immune apoptotic signaling and endocytosis regulation","description":"This cluster centers on immune cell signaling involving apoptosis (extrinsic pathway, dendritic cell apoptosis, beta selection), interferon/STAT signaling, and regulation of endocytosis (caveolin-mediated). The overlap of small GTPase signaling and protein tyrosine phosphorylation also supports coordinated signal transduction in immune responses.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008625","count":4},{"id":"GO:2001286","count":4},{"id":"GO:2000670","count":4},{"id":"GO:0043366","count":4},{"id":"GO:0007264","count":4}]},{"hash":"1785659504266918971","title":"Neural development and axon guidance","description":"The cluster's terms predominantly point to neuronal development and axon pathfinding (axonogenesis, motor neuron axon fasciculation, dendrite self-avoidance) and related cell-adhesion processes, suggesting a cohesive theme of neurite outgrowth and wiring. Some terms are unrelated or obsolete, but the core signal aligns with neural connectivity and guidance.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035260","count":2},{"id":"GO:1902960","count":2},{"id":"GO:1902955","count":2},{"id":"GO:1905240","count":2},{"id":"GO:0007156","count":2}]},{"hash":"2189312764349663928","title":"Inflammation and vascular remodeling","description":"Most terms favor inflammatory processes and vascular remodeling (NF-kappaB signaling, positive regulation of inflammatory response, blood vessel remodeling, coagulation). While other terms touch on gland morphogenesis and epithelial proliferation, the central theme tying these proteins together appears to be inflammation-linked tissue remodeling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072378","count":2},{"id":"GO:0042628","count":1},{"id":"GO:0032471","count":1},{"id":"GO:0043123","count":1},{"id":"GO:0060662","count":1}]},{"hash":"299509629988571411","title":"Spliceosome-Mediated mRNA Splicing","description":"The only annotated function is mRNA splicing via the spliceosome, suggesting these proteins are spliceosomal components or splicing factors; with a small cluster and no interaction edges, this label is descriptive and representative but based on limited evidence, hence a medium confidence.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":1}]},{"hash":"1717695569993295424","title":"Pole plasm oskar mRNA localization (Drosophila)","description":"The top GO terms point to oskar mRNA localization to the posterior pole plasm and its regulation during Drosophila oogenesis, with related germline RNA processing and oogenesis-related processes such as dorsal appendage formation, suggesting these proteins participate in Pole plasm and germline mRNA localization in Drosophila.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010526","count":2},{"id":"GO:0045451","count":1},{"id":"GO:2000637","count":1},{"id":"GO:0060269","count":1},{"id":"GO:0006402","count":1}]},{"hash":"1906556667398551250","title":"Neuronal development and polarity signaling","description":"Based on GO terms, the cluster centers on neural development and signaling: regulation of cell polarity establishment, Rho-mediated signal transduction, and forebrain morphogenesis, with additional hints of neuronal secretion control, oligodendrocyte differentiation, neuroblast proliferation, and cellular responses to cAMP. Although the proteins lack documented interactions in this dataset, their GO annotations converge on neural development and polarity-dependent signaling, suggesting they act as regulators of neuronal differentiation, brain patterning, and related signaling pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000114","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0071320","count":2},{"id":"GO:0046929","count":1},{"id":"GO:0001953","count":1}]},{"hash":"1427905929458503617","title":"GABAergic Synapse Signaling","description":"The top GO terms cluster around nervous system signaling, especially GABA receptor clustering, inhibitory postsynaptic potentials, and negative regulation of nerve impulse transmission, pointing to GABAergic synapses. Additional terms related to sensory processing and optic nerve development suggest broader CNS neural functions, with potassium ion transport tying to neuronal excitability. Overall, this set reflects inhibitory synaptic signaling in neurons.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:1905906","count":2},{"id":"GO:0021631","count":2},{"id":"GO:0060080","count":2},{"id":"GO:0035094","count":2}]},{"hash":"1437568555555553952","title":"Unknown","description":"The Top Terms include both chromatin organization (subtelomeric and pericentric heterochromatin formation) and a wide array of unrelated processes (ER unfolded protein response, extrinsic apoptosis signaling, neuronal migration, vascular remodeling, cytoskeleton, cell polarity, and GTPase regulation). There is no single coherent function or pathway tying all four proteins together, so a meaningful, specific label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":2},{"id":"GO:0030702","count":2},{"id":"GO:0060990","count":1},{"id":"GO:1900103","count":1},{"id":"GO:0008625","count":1}]},{"hash":"212455237032704686","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning multiple biosynthetic and catabolic processes (phylloquinone, melanin, propylene, androgen, estrogen, fatty acids, antibiotics, retinoic acid) plus an obsolete oxidation-reduction term. There is no single common pathway or function linking the proteins, and the cluster has no interactions, so a definite, cohesive label cannot be inferred.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0042376","count":1},{"id":"GO:0042438","count":1},{"id":"GO:0042208","count":1},{"id":"GO:0006710","count":1}]},{"hash":"1224108560727404198","title":"Strigolactone biosynthesis and shoot branching","description":"The top GO terms include strigolactone biosynthetic process and secondary shoot formation, both tied to a plant hormone pathway that governs shoot branching. While other terms reflect general metabolism and detoxification, the prominent strigolactone-related terms suggest a cohesive theme around this hormone pathway and plant development.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0006212","count":3}]},{"hash":"548565520266529068","title":"Embryonic patterning and organogenesis","description":"The GO terms cluster around early embryonic development, including primitive streak formation and forebrain/midbrain patterning with neuronal differentiation, as well as morphogenesis of multiple organs (thyroid, bronchi, digestive tract). This suggests a general theme of embryonic tissue patterning and organ formation rather than a single specific function.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":3},{"id":"GO:0021892","count":3},{"id":"GO:0021798","count":3},{"id":"GO:0030901","count":3},{"id":"GO:0048557","count":3}]},{"hash":"1495698389080539955","title":"Plant development and chromatin regulation","description":"Reasoning: The top GO terms cluster around transcriptional control and chromatin dynamics (RNA Pol II promoter initiation, histone exchange, nucleosome mobilization, acetylation, heterochromatin formation) and plant developmental processes (timing of vegetative-to-reproductive transition, segment specification) with related epidermal cuticle biosynthesis. The mix points to a functionally cohesive group involved in epigenetic regulation during plant development.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0048510","count":1},{"id":"GO:0042766","count":1},{"id":"GO:0006348","count":1}]},{"hash":"1317636308267004767","title":"Unknown","description":"The top GO terms are all regulatory but cover disparate processes (transcription, necroptosis/apoptosis, TLR signaling, ubiquitination) and even metabolic regulation, with no clear single function linking them. Beyond a loose \"regulation\" theme, there isn\u2019t a cohesive shared pathway or process to name the cluster precisely.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":1},{"id":"GO:0060544","count":1},{"id":"GO:0071157","count":1},{"id":"GO:0034121","count":1},{"id":"GO:0043066","count":1}]},{"hash":"2180187709934619561","title":"Eye development and visual perception","description":"This cluster is dominated by eye- and vision-related GO terms (retina vasculature development, visual perception) and includes supporting processes such as Notch signaling and microglia development that can influence retinal development, plus melanosome/endosome transport relevant to pigment cells in the eye. Together, these terms suggest a coherent theme around visual system development and function.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0007601","count":1}]},{"hash":"1259684507791940022","title":"Unknown","description":"The GO terms are highly diverse (lipid dephosphorylation, redox homeostasis, corneocyte development, aging, mRNA stability, base-excision repair, DNA recombination, glycogen regulation, cell migration). With no clear shared function or pathway binding all members and no edges connecting them, there isn\u2019t a coherent theme to label precisely.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046856","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2},{"id":"GO:0007568","count":2}]},{"hash":"401905419846174805","title":"DNA repair and redox homeostasis","description":"The cluster highlights redox homeostasis, base-excision repair, and DNA recombination, suggesting a core theme of genome maintenance under stress. Some terms like corneocyte development and aging appear less clearly connected, indicating annotation noise or broader cellular processes.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0003335","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0043488","count":2}]},{"hash":"1951334408646316389","title":"GABAergic Synaptic Transmission","description":"The cluster is dominated by terms related to inhibitory neurotransmission and GABA receptor dynamics (gamma-aminobutyric acid receptor clustering, inhibitory postsynaptic potential, negative regulation of nerve impulse transmission), which strongly point to GABAergic synapses as the core function. Additional terms about sensory perception of sound and optic nerve morphogenesis fit within broader neural circuitry contexts, supporting a neural-inhibition-centric theme. Confidence: High","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:1905906","count":4},{"id":"GO:0021631","count":4},{"id":"GO:0060080","count":4},{"id":"GO:0035094","count":4}]},{"hash":"1093282966769558518","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":1},{"id":"GO:2000637","count":1},{"id":"GO:0010586","count":1},{"id":"GO:1903265","count":1},{"id":"GO:1903883","count":1}]},{"hash":"888136333320514276","title":"Unknown","description":"The GO terms show no obvious shared function among the four proteins: redox homeostasis, corneocyte development, DNA repair/recombination, mRNA regulation, PI dephosphorylation, glycogen regulation, aging, and even inter-organism hemolysis. The terms span diverse processes from metabolism to genome maintenance to skin differentiation, and there are no edges linking the proteins in this cluster. Because there is no coherent theme connecting these annotations, a specific functional label cannot be confidently assigned beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":1},{"id":"GO:0014912","count":1},{"id":"GO:0003335","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0043488","count":1}]},{"hash":"5460059428174397","title":"Glycosylation and carbohydrate metabolism","description":"The terms point to protein glycosylation (including fucosylation) and carbohydrate metabolic processes; even though two terms are listed as obsolete, the shared theme is glycosylation-related modification of proteins and sugars.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0036065","count":1}]},{"hash":"1382927825456399483","title":"Unknown","description":"The GO terms are highly heterogeneous (retina/visual development, junction assembly, Notch signaling, melanosome transport, microglia development, viral attachment), with no single dominant function linking the proteins, suggesting the cluster lacks a coherent theme.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0007601","count":1}]},{"hash":"910015801963338643","title":"Embryonic and organ morphogenesis","description":"The GO terms cluster around development and morphogenesis across multiple tissues and organs (face, eyelid, skin barrier, cardiac ventricle, digits, cochlea) and epithelial migration, suggesting a shared role in shaping tissues during embryogenesis. An outlier term about mitochondrial protein import is incidental to this theme. Overall, the functions point to embryonic organ/tissue morphogenesis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":1},{"id":"GO:0060487","count":1},{"id":"GO:0061436","count":1},{"id":"GO:0044030","count":1},{"id":"GO:0061029","count":1}]},{"hash":"1807666410320016192","title":"Signaling and Endocytosis","description":"The proteins in this cluster touch on multiple signaling pathways (small GTPase/Rho signaling, JNK regulation, insulin receptor signaling) and vesicle trafficking (clathrin-dependent endocytosis), plus some development-related processes. The terms point to a broad theme of intracellular signaling and membrane trafficking rather than a single cohesive function, so a general label like Signaling and Endocytosis captures the common thread without overstretching specificity.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007281","count":1},{"id":"GO:0072583","count":1},{"id":"GO:0007264","count":1},{"id":"GO:0032287","count":1},{"id":"GO:0090307","count":1}]},{"hash":"1281653277106456301","title":"Zinc Ion Transport and Homeostasis","description":"The top GO terms cluster around zinc import across membranes, intracellular zinc ion homeostasis, and zinc ion transport (including cadmium transport) with a zinc starvation response, indicating a cohesive theme of zinc handling; a few development/DNA-related terms may reflect pleiotropy rather than shared function.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001713","count":1},{"id":"GO:0071897","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0034224","count":1},{"id":"GO:0060173","count":1}]},{"hash":"1560900712831908484","title":"Mitochondrial Transport and Membrane Potential Regulation","description":"The terms cluster around mitochondria: membrane potential regulation, transport of metabolic cofactors across mitochondrial membranes (citrate, CoA, NAD), and responses to oxidative stress and apoptotic changes. The inclusion of IGF-stimulus and liver regeneration suggests a metabolic/regenerative context. Overall, the common theme is mitochondrial transport and regulation of mitochondrial function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":1},{"id":"GO:0008637","count":1},{"id":"GO:0097421","count":1},{"id":"GO:0046902","count":1},{"id":"GO:0006843","count":1}]},{"hash":"1752591390655019197","title":"Nucleocytoplasmic transport and RNA export","description":"The top GO terms are dominated by nuclear-cytoplasmic transport activities (nuclear pore complex assembly, mRNA export, tRNA transport, Ran signaling, snRNP import), with additional signals related to related transport roles in mitosis and intraciliary transport. This suggests a cohesive function around moving macromolecules between the nucleus and cytoplasm, occasionally linked to cell division and ciliary transport.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006608","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0051031","count":1},{"id":"GO:0030953","count":1},{"id":"GO:0031291","count":1}]},{"hash":"316950215488401146","title":"Unknown","description":"The top GO terms include glycosylation-related processes alongside plant and animal developmental terms and viral processes, with no clear, single functional theme tying the proteins together.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006488","count":1},{"id":"GO:0048366","count":1},{"id":"GO:0006487","count":1},{"id":"GO:0060117","count":1},{"id":"GO:0075713","count":1}]},{"hash":"2229619447009967642","title":"Neural and muscular electrical signaling","description":"The GO terms converge on processes of electrical signaling and communication in excitable tissues: high voltage-gated calcium channel activity, membrane depolarization, and rhythmic synaptic transmission point to neurons and muscles; neuromuscular junction development and regulation of heart rate by cardiac conduction extend to motor systems and cardiac tissue; even pharyngeal pumping in nematodes and light detection reflect neuronal control of physiological responses. Together they suggest a cluster of proteins involved in excitability and neuro-muscular signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043050","count":1},{"id":"GO:0061577","count":1},{"id":"GO:0086048","count":1},{"id":"GO:0086091","count":1},{"id":"GO:0050908","count":1}]},{"hash":"152455853854439764","title":"Potassium homeostasis and membrane excitability","description":"The cluster centers on potassium ion regulation and membrane potential dynamics in excitable cells, including neurons and cardiac muscle. GO terms emphasize intracellular potassium homeostasis, potassium transport, resting potential regulation, membrane stabilization, and atrial repolarization, pointing to ion balance and excitability as the main theme; a small number of terms about cytokinesis and cell division appear incidental to the core function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0050976","count":2},{"id":"GO:0098914","count":2},{"id":"GO:0060075","count":2}]},{"hash":"1866835866051159795","title":"Differentiation and Translational Regulation","description":"This small cluster centers on development-related differentiation (skeletal muscle, neuron, germ-line stem cell maintenance) and control of protein synthesis (translation initiation, viral translation mechanisms, and regulation of deneddylation). The GO terms suggest a theme of developmental processes intertwined with translation regulation, possibly reflecting proteins that coordinate cell fate decisions with translational control. Given the limited terms and modest cluster size, confidence is Moderate.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":1},{"id":"GO:0075522","count":1},{"id":"GO:0006446","count":1},{"id":"GO:0034260","count":1},{"id":"GO:0036099","count":1}]},{"hash":"23053475334631141","title":"Protein quality control and autophagy","description":"The dominant GO terms point to proteostasis activities: chaperone-assisted protein folding, chaperone complex assembly, aggresome formation, and autophagy-related processes (late endosomal microautophagy, autophagosome maturation). Although there are a few unrelated terms in the list, the recurring theme centers on handling misfolded proteins and their degradation via autophagy and related pathways. Given the small cluster size and some noise, the label is best described as a proteostasis/autophagy-focused cluster rather than a single highly specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":1},{"id":"GO:1903007","count":1},{"id":"GO:0070389","count":1},{"id":"GO:0018279","count":1},{"id":"GO:0051131","count":1}]},{"hash":"1513980237411703913","title":"Neural development: axon guidance and dendrite patterning","description":"The top GO terms emphasize axonogenesis, motor neuron axon fasciculation, dendrite self-avoidance, and cell\u2013cell adhesion, all pointing to neural wiring and connectivity during development. Hedgehog/Smoothened signaling also supports developmental patterning. A few terms (prolactin signaling, NK cell differentiation) are peripheral or noisy for this cluster, but the dominant signal is neuronal connectivity, suggesting the label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":3},{"id":"GO:1902955","count":3},{"id":"GO:1905240","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0050772","count":3}]},{"hash":"769067462555409485","title":"Unknown","description":"The terms cover GPCR-related signaling (adenylate cyclase activation, MAPK-activating adrenergic signaling, dopamine receptor signaling), cytokine production regulation (IL-6, IL-1\u03b2), histamine response, and immune cell trafficking (eosinophil chemotaxis), with a couple unrelated processes like saliva secretion and visual learning. This dispersion suggests no single coherent function dominates the cluster, so the label Unknown best fits.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032675","count":1},{"id":"GO:0046541","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0071883","count":1},{"id":"GO:0034776","count":1}]},{"hash":"314339806871405647","title":"Unknown","description":"The GO terms span unrelated biological contexts (hair cycle, blood vessel maturation, B cell differentiation, synapse assembly, hearing, oligodendrocyte proliferation, lipoprotein signaling), with no clear shared function or pathway, and the cluster has no edges, making a cohesive label unlikely.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045317","count":1},{"id":"GO:0048105","count":1},{"id":"GO:0001955","count":1},{"id":"GO:0051796","count":1},{"id":"GO:0002315","count":1}]},{"hash":"953567407269763438","title":"Cell cycle regulation and cytoskeleton dynamics","description":"The top GO term is regulation of the cell cycle, with additional signals of cytoskeletal localization/remodeling, suggesting these proteins coordinate cell proliferation with cytoskeletal changes. There are also developmental signals (endodermal fate, heart-related terms) that align with proliferation and differentiation coordination, though some terms are more peripheral. Overall, the cluster appears to center on cell cycle control linked to cytoskeletal dynamics during development.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":3},{"id":"GO:0061324","count":2},{"id":"GO:0072699","count":2},{"id":"GO:0000011","count":2},{"id":"GO:0061198","count":2}]},{"hash":"1760032562802919861","title":"Embryonic organ morphogenesis","description":"The GO terms place emphasis on early development stages (primitive streak formation; forebrain/midbrain development; GABAergic interneuron differentiation and fate commitment) and broad organ morphogenesis (digestive tract, metanephric kidney, bronchioles, superior vena cava). This pattern suggests proteins involved in general embryonic morphogenesis across multiple organs rather than a single tissue-specific function, justifying the label.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":2},{"id":"GO:0021892","count":2},{"id":"GO:0021798","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0048557","count":2}]},{"hash":"1872104612629910677","title":"Chromatin Regulation and Nuclear Transport","description":"This cluster features GO terms centered on chromatin organization, histone acetylation, and peptidyl-serine dephosphorylation, along with nuclear pore localization, suggesting a nucleus-focused regulatory role in gene expression. Additional terms involving cilium assembly and retina development can connect through ciliogenesis and differentiation, while mitotic spindle assembly and vesicle transport reflect broader cell biology accompanying nuclear processes. Overall, the proteins seem linked by a nucleus-centric regulatory program with supporting roles in ciliary/eye development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070262","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0060271","count":1},{"id":"GO:0031081","count":1},{"id":"GO:0090307","count":1}]},{"hash":"1673335560261251174","title":"Vesicle Exocytosis and Secretory Pathways","description":"The strongest terms are vesicle fusion and regulation of dense core granule and synaptic vesicle exocytosis, pointing to secretory vesicle trafficking and neurotransmitter release. Some annotations (brain development, abscisic acid signaling) may reflect broader regulatory roles or cross-annotation, but the core theme is vesicle fusion/exocytosis. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006906","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0009789","count":2},{"id":"GO:1905415","count":1}]},{"hash":"247989284011056569","title":"Membrane adhesion and receptor signaling","description":"The cluster shows membrane-associated signaling and adhesion features: ephrin receptor signaling, substrate adhesion-dependent spreading, and caveolin-mediated endocytosis regulation, with supportive small GTPase signaling. These together suggest a theme of membrane receptor\u2013mediated communication and endocytic regulation, with ancillary links to apoptotic and interferon pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034446","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0008625","count":2},{"id":"GO:2001286","count":2},{"id":"GO:2000670","count":2}]},{"hash":"724987373074311529","title":"Unknown","description":"This cluster has no GO terms or apparent connections (no edges or triangles) among the proteins, so there isn\u2019t a coherent shared function to label. Without a unifying function or process, the appropriate label is Unknown. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"452517954043425271","title":"Lipid metabolism and lipoprotein regulation","description":"The cluster centers on lipid handling: cholesterol storage, triglyceride biosynthesis, and regulation of plasma lipoprotein particles, with related processes like cholesterol esterification and foam cell differentiation in macrophages. It also includes inflammatory responses to LPS and xenobiotics, suggesting a combined role in lipid metabolism and lipid-driven inflammation. The heart development term appears incidental rather than central to the cluster\u2019s theme.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0010878","count":1},{"id":"GO:0010742","count":1}]},{"hash":"881570415328509613","title":"Aminoacyl-tRNA Synthetases and Translation","description":"This cluster is dominated by GO terms for cytoplasmic translation and multiple mitochondrial tRNA aminoacylation activities (glycyl, prolyl, threonyl, histidyl, alanyl, etc.), indicating components of the protein synthesis machinery responsible for charging tRNAs in both cytoplasm and mitochondria.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0070150","count":1},{"id":"GO:0006433","count":1},{"id":"GO:0071897","count":1}]},{"hash":"116625633867650634","title":"Cell death and inflammatory signaling regulation","description":"The top GO terms point to regulation of necroptosis and apoptosis, JNK signaling, and NF-kB pathway control (via I-kappaB phosphorylation), all centered on cellular signaling that determines survival or death. Ubiquitination and receptor turnover terms support a regulatory mechanism layer, while broader terms like histone modification and V(D)J recombination suggest transcriptional and immune system regulatory context. Overall, these terms cluster around how cells regulate death and inflammatory signaling, not a single enzyme or pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060544","count":1},{"id":"GO:0070512","count":1},{"id":"GO:0036205","count":1},{"id":"GO:1903721","count":1},{"id":"GO:1901253","count":1}]},{"hash":"1665872299997077722","title":"Epithelial adhesion and polarity machinery","description":"The terms cluster around epithelial cell junctions and polarity, including adherens junction organization, bicellular tight junction assembly, and establishment/maintenance of apical/basal polarity, plus related processes like focal adhesion regulation and wound healing. Exosomal secretion and exocrine development are more peripheral but may reflect broader cell communication roles; overall, the cluster centers on cell adhesion, junction formation, and tissue organization.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035272","count":1},{"id":"GO:0060079","count":1},{"id":"GO:0090307","count":1},{"id":"GO:1902766","count":1},{"id":"GO:0035088","count":1}]},{"hash":"87498585311781034","title":"Oxidative-Stress Mitochondrial Apoptosis and Trafficking","description":"The GO terms point to oxidative stress\u2013driven mitochondrial regulation and intrinsic apoptotic signaling, which is a coherent core theme. The ER-to-Golgi vesicle transport and membrane transport term are secondary processes that can accompany cellular stress responses, supporting a broader \"stress response leading to apoptosis and trafficking changes\" theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010917","count":1},{"id":"GO:0002037","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0008631","count":1}]},{"hash":"2153487180054290529","title":"RNA transcription machinery and ribosome biogenesis","description":"Top GO terms indicate involvement in RNA polymerase I/II/III\u2013mediated transcription, transcription elongation and termination, and ribosome biogenesis, suggesting these proteins are part of the nuclear transcription apparatus with links to ribosome assembly. The cluster appears to group proteins associated with core transcription processes and ribosome biogenesis rather than a single narrowly defined function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0006360","count":1}]},{"hash":"345245301097270456","title":"Nutrient-sensing growth signaling and translation control","description":"The GO terms cluster around nutrient and growth signaling (TOR signaling, insulin receptor pathway), cell cycle progression (G1/S transition, positive regulation of the mitotic cycle), and translational control (IRES-dependent initiation and its regulation), with an amino acid starvation response reinforcing a nutrient-sensing theme. Minor outliers like dexamethasone response or social behavior annotations don\u2019t override the dominant theme of growth and translation control. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019933","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0002192","count":1},{"id":"GO:0008286","count":1},{"id":"GO:1990928","count":1}]},{"hash":"2214183486426892332","title":"Autophagy and Endosome Maturation","description":"The top GO terms include autophagosome maturation and late endosomal microautophagy, suggesting involvement in autophagy-lysosome pathways; other terms (DNA replication, ion transport) are sparse and may reflect mixed or indirect annotations, so the label concentrates on the clearest shared function without overclaiming.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006813","count":2},{"id":"GO:0032968","count":1},{"id":"GO:1903007","count":1},{"id":"GO:0070389","count":1}]},{"hash":"1281599791356992586","title":"Neural development and GABAergic signaling","description":"The top GO terms are strongly skewed toward brain and nervous system development (brain development, nervous system development) and GABAergic synaptic transmission, suggesting the cluster centers on neuronal differentiation and inhibitory synapses. While there are a few non-neuronal terms present, the neural signals dominate, supporting a neural development/ GABAergic function theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045176","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0051932","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0007399","count":3}]},{"hash":"795002021987245633","title":"DNA replication and chromatin remodeling","description":"The top GO terms are dominated by DNA replication (GO:0006260) and chromatin remodeling (GO:0043044), with centrosome cycle (GO:0007098) also present, pointing to nuclear/cell-cycle and chromatin-regulation functions. Other terms (insulin signaling, glucose signaling, mating type switching, biofilm formation, viral genome replication) occur at lower frequency and may reflect broader or downstream annotations. Overall, the cluster seems representative of nuclear processes involved in DNA synthesis and chromatin dynamics more than extracellular signaling or metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0008286","count":2},{"id":"GO:1902661","count":2},{"id":"GO:0043044","count":2},{"id":"GO:0061412","count":2}]},{"hash":"1892907156717594813","title":"Organ and tissue development","description":"The GO terms cluster around development and differentiation across multiple tissues (eye epithelium, nephric/ureteric bud, tracheal cartilage, lymphatic endothelium, neuron timing, sex determination), indicating a shared theme of organogenesis rather than a single pathway. This supports labeling as Organ and tissue development.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003406","count":2},{"id":"GO:0060164","count":2},{"id":"GO:0060534","count":2},{"id":"GO:0071376","count":2},{"id":"GO:0060838","count":2}]},{"hash":"987910064067543118","title":"Epithelial junctions and polarity","description":"The top terms cluster around cell-cell adhesion and tissue organization, including adherens and tight junction assembly, apical/basal polarity establishment, focal adhesion regulation, and wound healing, indicating a cohesive theme of epithelial junctions and polarity (with some broader developmental terms as minor outliers).","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035272","count":1},{"id":"GO:0060079","count":1},{"id":"GO:0090307","count":1},{"id":"GO:1902766","count":1},{"id":"GO:0006413","count":1}]},{"hash":"727298140620627064","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around broad developmental processes across tissues, including cartilage morphogenesis, left/right pattern formation, epithelial-to-mesenchymal transitions in heart-related tissues, endocrine system development, and blood vessel maturation. This points to embryonic development and tissue/organ morphogenesis rather than a single specific function. Confidence: High","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0003323","count":1}]},{"hash":"1874847383294535724","title":"Unknown","description":"The GO terms span diverse processes (developmental patterning, eyelid and organ morphogenesis, liver regeneration, erythrocyte differentiation), stress responses (ER unfolded protein response, PERK pathway) and calcium signaling, with no single cohesive function linking them all. Therefore, no specific shared function is evident beyond broad cellular stress and development themes, so Unknown with None.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":2},{"id":"GO:0035994","count":2},{"id":"GO:1900103","count":2},{"id":"GO:0043923","count":2},{"id":"GO:0071277","count":2}]},{"hash":"2000283036100044693","title":"Neuronal ion channels and excitability","description":"The top GO terms center on ion transport across membranes (calcium, sodium, potassium), voltage-gated calcium channels, and membrane depolarization linked to neuronal action potentials (including Purkinje cells). Additional terms involve sensory perception and circadian regulation, all pointing to neuronal signaling and excitability. Overall, this cluster seems to group proteins involved in neuronal ion channel function and action potential propagation.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0001964","count":3},{"id":"GO:0045188","count":3},{"id":"GO:0019228","count":2}]},{"hash":"326284021326217125","title":"Neuronal adhesion and axon guidance","description":"The cluster is dominated by terms tied to neural development and wiring, such as homophilic cell-cell adhesion, axonogenesis, motor neuron axon fasciculation, and dendrite self-avoidance, with supporting signals from Hedgehog (smoothened) pathways. These collectively indicate a function related to neuronal connectivity and axon guidance, making this a coherent label despite some peripheral terms.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":3},{"id":"GO:1902955","count":3},{"id":"GO:1905240","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0050772","count":3}]},{"hash":"1450829855181509405","title":"GABAergic synapses and neuronal excitability","description":"The GO terms emphasize GABA receptor clustering and inhibitory postsynaptic potentials, along with ion transport that governs neuronal excitability. Behavioral associations (startle, conditioned taste aversion, nicotine response) and circadian regulation reflect neural circuit control, with optic nerve morphogenesis suggesting neural development. This combination supports a label focused on GABAergic signaling and neuronal excitability.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0001964","count":3},{"id":"GO:0045188","count":3},{"id":"GO:1905906","count":2}]},{"hash":"920438907536916836","title":"Unknown","description":"The GO terms are scattered across immune differentiation, epigenetic regulation, ubiquitination, vitamin D response, TNF signaling, and development, with no clear shared function and no edges among proteins. This lack of a cohesive theme means a meaningful, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061470","count":1},{"id":"GO:1901253","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0043045","count":1},{"id":"GO:0033280","count":1}]},{"hash":"530768590074650213","title":"Ion-channel\u2013driven action potential signaling","description":"The top GO terms highlight action potentials, membrane depolarization, and ion transport through voltage-gated calcium and sodium channels, pointing to a theme of electrical signaling in excitable cells (neuronal and cardiac). Peripheral terms like pain detection and some signaling pathways are present but do not define the core function. Thus the cluster is best described as ion-channel\u2013driven excitability.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019228","count":1},{"id":"GO:0007259","count":1},{"id":"GO:0061577","count":1},{"id":"GO:0086047","count":1},{"id":"GO:0098719","count":1}]},{"hash":"1710948113511264429","title":"Sterol metabolism and cholesterol homeostasis","description":"Dominant cholesterol-related terms (regulation of cholesterol biosynthetic process, cholesterol homeostasis, and SREBP signaling) indicate the cluster centers on sterol metabolism and its regulation. Other GO terms appear less cohesive (e.g., visual learning, chlorate response, SHH-related signaling), suggesting some annotations are incidental, but the cholesterol metabolism theme is strongest.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010157","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0072203","count":1},{"id":"GO:0060831","count":1},{"id":"GO:0015936","count":1}]},{"hash":"1563549604565586970","title":"Vertebrate embryonic development and morphogenesis","description":"The terms cluster around early embryogenesis and broad morphogenesis across multiple organs, including primitive streak formation, forebrain and midbrain patterning, cortical interneuron differentiation, and organ-specific morphogenesis (thyroid, bronchioles, digestive tract). This suggests a general developmental program active during vertebrate embryogenesis rather than a single tissue-specific function, justifying a label like vertebrate embryonic development and morphogenesis.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":3},{"id":"GO:0021892","count":3},{"id":"GO:0021798","count":3},{"id":"GO:0030901","count":3},{"id":"GO:0048557","count":3}]},{"hash":"1353202575023911906","title":"Unknown","description":"The top GO terms are highly diverse (immune signaling like regulation of IL-6 and IL-1\u03b2 production, histamine response, eosinophil chemotaxis; neurotransmitter signaling such as dopamine receptor pathways and adenylate cyclase activation; saliva secretion and even a learning-related term), with each term represented by only one protein and no reported interactions between the proteins. There is no coherent shared function tying these proteins together, so a generic Unknown label is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032675","count":1},{"id":"GO:0046541","count":1},{"id":"GO:0008542","count":1},{"id":"GO:0071883","count":1},{"id":"GO:0034776","count":1}]},{"hash":"323222795669713550","title":"Germline Chromatin Regulation by Histone Acetylation","description":"The cluster\u2019s GO terms are centered on histone acetylation across multiple histones (H3, H2A, H4) and chromatin-state regulation, including heterochromatin formation and responses linked to DNA damage, with some male germline development terms (germline stem cell division, meiosis). This points to chromatin modification controlling gene expression in germline contexts. Despite no reported interactions, the shared theme is histone acetylation\u2013driven chromatin regulation in germ cells.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":1},{"id":"GO:0043968","count":1},{"id":"GO:0008285","count":1},{"id":"GO:0043982","count":1},{"id":"GO:0061186","count":1}]},{"hash":"2266640615229333618","title":"Bacterial small-molecule metabolism and cofactor biosynthesis","description":"The GO terms show a mix of biosynthetic and catabolic pathways for small molecules, including antibiotic biosynthesis, menaquinone and phylloquinone (cofactor) biosynthesis, fatty acid beta-oxidation, TCA cycle, and amino acid metabolism (valine, phenylalanine, glutamine). This pattern suggests a cluster of enzymes involved in broad bacterial metabolism of lipids, amino acids, and cofactors rather than a single specific pathway.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0006635","count":2},{"id":"GO:0006574","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0010124","count":2}]},{"hash":"280677705498321286","title":"Unknown","description":"The proteins show a broad mix of functions across lipid metabolism, immune response, proteoglycan biosynthesis, and development signaling, with no clear, shared pathway or process. There are no interactions among them in the data, and the GO terms are diverse (mostly singletons), so a cohesive, specific label isn\u2019t supported.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030210","count":1},{"id":"GO:0031639","count":1},{"id":"GO:0051005","count":1},{"id":"GO:0070328","count":1},{"id":"GO:0044320","count":1}]},{"hash":"146374843916072972","title":"GABAergic Inhibitory Synapses and Auditory Signaling","description":"This cluster shows strong enrichment for GO terms related to GABA receptor clustering, inhibitory postsynaptic potentials, and negative regulation of nerve impulse transmission, combined with sensory perception of sound. These together point to GABAergic synaptic inhibition and auditory processing as the core theme, with additional neural-development or modulatory terms present but secondary. Confidence: High","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:1905906","count":2},{"id":"GO:0021631","count":2},{"id":"GO:0060080","count":2},{"id":"GO:0035094","count":2}]},{"hash":"1818925821813376423","title":"Innate Immune Response and Complement Activation","description":"The cluster is dominated by GO terms related to innate immunity: phagocytosis recognition, basophil activation, lectin pathway complement activation, and modulation of NK cell chemotaxis, as well as a cellular response to fungal origin. A few kidney development terms appear incidental, suggesting annotation noise rather than a shared developmental function; overall, the core theme is innate immune mechanisms and complement activity.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":2},{"id":"GO:0006910","count":1},{"id":"GO:0072218","count":1},{"id":"GO:0045575","count":1},{"id":"GO:0051873","count":1}]},{"hash":"1259230925384842645","title":"Unknown","description":"The top GO terms span neuronal plasticity, meiosis, chiasma assembly, and several developmental processes (brain, reproductive organs, blood/immune tissues) with no clear shared function or pathway. This suggests the cluster does not map to a cohesive, identifiable biological function, so Unknown with no confidence is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":2},{"id":"GO:0007129","count":1},{"id":"GO:0051026","count":1},{"id":"GO:0008542","count":1},{"id":"GO:2001040","count":1}]},{"hash":"478565624589307740","title":"Photoreception and Visual Signaling","description":"This cluster is dominated by GO terms tied to vision: detection of light stimulus involved in visual perception, visual perception, and visual behavior, complemented by histamine transport, which aligns with histaminergic signaling in photoreceptors. While other terms (calcium/mitochondrial regulation, protein adenylylation, insulin secretion, etc.) appear, the strongest shared function among these proteins points to photoreceptor signaling and visual processing.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051608","count":1},{"id":"GO:0050908","count":1},{"id":"GO:1900723","count":1},{"id":"GO:0039604","count":1},{"id":"GO:0018117","count":1}]},{"hash":"954285617499696810","title":"Developmental Signaling and Morphogenesis","description":"The top GO terms cluster around regulation and processing of signaling pathways (protein tyrosine kinase activity regulation, peptidyl-tyrosine phosphorylation, Notch processing) and developmental/tissue morphogenesis processes (tube development, sprouting angiogenesis, palatal shelf morphogenesis, axon regeneration). While a couple of terms are more specific to bone or lipid signaling, the overarching theme is signaling-mediated development and morphogenesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061097","count":2},{"id":"GO:0007220","count":2},{"id":"GO:1990134","count":2},{"id":"GO:0045124","count":2},{"id":"GO:2000969","count":2}]},{"hash":"638018254405682145","title":"Metabolic Biosynthesis and Degradation","description":"These terms span diverse biosynthetic and catabolic processes (phylloquinone, melanin, propylene, androgen/estrogen, fatty acid elongation, antibiotics, retinoic acid, etc.). The unifying theme is general metabolism\u2014production or degradation of various metabolites\u2014rather than a specific functional module, so the label reflects broad metabolic activity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042376","count":1},{"id":"GO:0042438","count":1},{"id":"GO:0042208","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0006710","count":1}]},{"hash":"2040718189049616344","title":"Chromatin organization and transcription regulation","description":"The enriched GO terms cluster around chromatin assembly/remodeling, heterochromatin formation, and transcriptional control by RNA polymerase II, with ties to cell cycle regulation and centromere/chromatin localization, indicating a chromatin-centric functional theme.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006335","count":2},{"id":"GO:0045815","count":2},{"id":"GO:0051290","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1506114349738668308","title":"Vertebrate neural and organ morphogenesis","description":"The terms indicate neural development (cortex interneuron differentiation and fate commitment, forebrain/midbrain patterning) alongside diverse embryonic organ morphogenesis (digestive tract, bronchiole, thyroid, vena cava), pointing to a vertebrate embryonic development theme with both neural patterning and organ formation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":2},{"id":"GO:0021892","count":2},{"id":"GO:0021798","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0048557","count":2}]},{"hash":"109855315660569218","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070512","count":2},{"id":"GO:0036205","count":2},{"id":"GO:1903721","count":2},{"id":"GO:0006295","count":2},{"id":"GO:0042769","count":2}]},{"hash":"12041861245640782","title":"Embryonic Organ Development and Growth","description":"The top GO terms are dominated by development and morphogenesis across multiple organs (kidney metanephric development, palatal shelf formation, cardiac muscle growth, neuronal stem cell maintenance, etc.), suggesting a cohesive theme of embryonic tissue development and growth. A single immune-related term appears but does not override the developmental pattern.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":2},{"id":"GO:0001867","count":2},{"id":"GO:1902462","count":1},{"id":"GO:1900142","count":1},{"id":"GO:0072233","count":1}]},{"hash":"2286888920001606403","title":"SNARE-Mediated Vesicle Fusion","description":"The cluster centers on vesicle trafficking and membrane fusion: SNARE complex assembly, vesicle fusion with the Golgi, intra-Golgi and endosome\u2013Golgi transport, exocytic insertion of receptors, and NK cell degranulation\u2014all hallmark SNARE-driven fusion events. A few regulatory terms are present but do not override the core theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":1},{"id":"GO:0050819","count":1},{"id":"GO:0010951","count":1},{"id":"GO:0048280","count":1},{"id":"GO:0043320","count":1}]},{"hash":"1795568325709055876","title":"Vertebrate organogenesis","description":"The top GO terms point to embryonic development across multiple organs (kidney/metanephros, lung, spinal cord, cartilage, placenta, mesonephric duct, hair cell differentiation), rather than a single tissue or process. This suggests a cohesive theme of vertebrate embryonic organ formation, so a concise label like Vertebrate organogenesis captures the shared function of these proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":1},{"id":"GO:0048903","count":1},{"id":"GO:0033319","count":1},{"id":"GO:0060428","count":1},{"id":"GO:0042994","count":1}]},{"hash":"1669194170344351003","title":"Immune signaling and apoptosis regulation","description":"Top GO terms point to extrinsic apoptotic signaling, dendritic cell apoptosis, interferon signaling, T cell development, STAT phosphorylation, and small GTPase signaling, with additional references to endocytosis regulation and mitochondrial ATP synthase assembly. This combination suggests a functional theme of immune cell signaling intertwined with regulation of apoptosis. Thus, a concise label 'Immune signaling and apoptosis regulation' reflects the core shared processes in this cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033615","count":1},{"id":"GO:0008625","count":1},{"id":"GO:2001286","count":1},{"id":"GO:2000670","count":1},{"id":"GO:0043366","count":1}]},{"hash":"957342375609121055","title":"ECM Remodeling and Proteostasis","description":"The terms cluster around extracellular matrix dynamics and protein turnover: hyaluronan metabolic process, negative regulation of extracellular matrix assembly, heterotypic cell-cell adhesion, and positive regulation of metallopeptidase activity point to ECM remodeling, while ubiquitin-dependent protein catabolic process and proteasome assembly reflect proteostasis. A few terms (T cell activation, chlorophyll biosynthetic process) appear as outliers and do not fit the core theme, which is why the label emphasizes ECM remodeling with protein turnover.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002291","count":1},{"id":"GO:0035987","count":1},{"id":"GO:1901202","count":1},{"id":"GO:0030212","count":1},{"id":"GO:0034113","count":1}]},{"hash":"1415811489125722736","title":"GTPase signaling and cytoskeleton-driven cell migration","description":"This cluster is driven by terms emphasizing GTPase activity and small GTPase\u2013mediated signal transduction, along with microtubule-based movement and cell migration. While some terms touch on development and endocytosis, the strongest common theme is GTPase-regulated cytoskeletal dynamics governing cell movement, suggesting a functional grouping around signaling to reorganize the cytoskeleton and promote migration.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0007018","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0007281","count":1}]},{"hash":"980469503869074393","title":"TLR-Driven Innate Immune Signaling","description":"The proteins are enriched for Toll-like receptor signaling (TLR2/4), innate immune response, NF-\u03baB activation, inflammatory response, and cytokine production (e.g., IL-8), with responses to LPS and dsRNA, and defenses against Gram-positive bacteria, indicating a cluster of TLR-driven innate immune signaling components.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0031663","count":2},{"id":"GO:0034142","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0043330","count":2}]},{"hash":"492069069179448003","title":"Meiotic telomere maintenance and DNA repair","description":"The top GO terms center on telomere maintenance (via recombination and lengthening), premeiotic DNA replication, and DNA repair, all tied to meiosis in pollen development, with supplementary telomere localization. Translation-related terms appear (tRNA aminoacylation and wobble modification) but do not outweigh the telomere/meiotic maintenance theme. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0009555","count":1},{"id":"GO:0006430","count":1},{"id":"GO:0006279","count":1},{"id":"GO:0000722","count":1}]},{"hash":"1931017001517819175","title":"Unknown","description":"Top terms are empty, and with only two edges among three proteins, there is no clear shared function to base a label on. Consequently, I cannot assign a specific, representative name.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"624397847491325551","title":"Diverse membrane transporters","description":"The top GO terms point to transmembrane transport across multiple substrates (vitamins, nitrate, sugars, xenobiotics, potassium) and vesicular neurotransmitter loading, indicating a cluster of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0015706","count":2}]},{"hash":"1971325653999406019","title":"Actin cytoskeleton remodeling and signaling","description":"The GO terms cluster around actin assembly/remodeling, small GTPase\u2013mediated signaling, and membrane trafficking, with neuron-related contexts like dendritic spine maintenance and PNS myelin maintenance, suggesting proteins coordinating cytoskeletal dynamics with signaling for neural structure and function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001286","count":1},{"id":"GO:1990314","count":1},{"id":"GO:0000147","count":1},{"id":"GO:0007264","count":1},{"id":"GO:0032287","count":1}]},{"hash":"1189320873912524471","title":"Unknown","description":"There is no common GO term or network signal among the three proteins: no edges, no shared annotations, and the top terms list is empty. Without functional clues, a meaningful label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1429085705127329151","title":"Diverse transmembrane transport","description":"This cluster is characterized by GO terms pointing to a broad set of membrane transport activities across ions (K+, Na+, phosphate), nutrients (galactose, vitamin, hydroxyphenylacetate), and other substrates, plus processes like neurotransmitter loading into synaptic vesicles. The common thread is transmembrane transport rather than a single substrate or transporter type, so a concise label focusing on diverse membrane transport captures the cluster\u2019s function.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0015757","count":2}]}]