{"hash":"1417493526305046510","title":"Proteasome-driven antigen presentation and immune signaling","description":"The GO terms point to a cluster centered on antigen processing and presentation via MHC class I (including TAP-dependent transport), coupled to proteasome-related proteolysis (proteasome core assembly, ubiquitin-dependent degradation, and deubiquitination) and immune receptor signaling (TCR and Fc-epsilon pathways). This suggests a functional theme where proteasome- and ubiquitin-mediated processing feeds antigen presentation and downstream immune signaling. The presence of a viral process term further supports a host immune response context.","confidence":"High","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"members":[{"accession":"XP_005826102.1","go_terms":["GO:0006284","GO:0097510"]},{"accession":"XP_005832233.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_005837120.1","go_terms":["GO:0006284","GO:0097510"]},{"accession":"XP_005826045.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_005835739.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_005822027.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_005838338.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]}],"graph":[["XP_005822027.1","XP_005826045.1",0.797],["XP_005822027.1","XP_005826102.1",0.966],["XP_005822027.1","XP_005835739.1",0.948],["XP_005822027.1","XP_005832233.1",0.623],["XP_005822027.1","XP_005838338.1",0.93],["XP_005822027.1","XP_005837120.1",0.648],["XP_005832233.1","XP_005835739.1",0.912],["XP_005832233.1","XP_005838338.1",0.84],["XP_005832233.1","XP_005826102.1",0.939],["XP_005837120.1","XP_005826045.1",0.599],["XP_005837120.1","XP_005826102.1",0.642],["XP_005837120.1","XP_005835739.1",0.943],["XP_005837120.1","XP_005838338.1",0.957],["XP_005835739.1","XP_005838338.1",0.961],["XP_005835739.1","XP_005826045.1",0.843],["XP_005835739.1","XP_005826102.1",0.985],["XP_005838338.1","XP_005826045.1",0.573],["XP_005838338.1","XP_005826102.1",0.93],["XP_005826102.1","XP_005826045.1",0.654]],"all_go_terms":{"GO:0006284":2,"GO:0097510":2,"GO:0016032":5,"GO:0002479":5,"GO:0016579":5,"GO:0080129":5,"GO:0038095":5,"GO:0031146":5,"GO:0090090":5,"GO:0010950":5,"GO:0046686":5,"GO:0050852":5,"GO:0010499":5,"GO:0038061":5,"GO:0043488":5,"GO:0090263":5,"GO:0010363":5,"GO:0061418":5,"GO:0006521":5,"GO:0051437":5,"GO:0060071":5,"GO:0009651":5,"GO:0002862":5,"GO:0002223":5,"GO:0031145":5,"GO:0033209":5,"GO:0051436":5,"GO:0010043":5,"GO:0010972":5},"recipe_readded":[]}