{"hash":"2158188680217483061","title":"Amino acid metabolism","description":"This cluster is dominated by terms related to amino acid biosynthesis and catabolism (lysine via aminoadipic acid, L-alanine, L-kynurenine, L-phenylalanine, L-threonine) and the central carbon metabolism link to the TCA cycle, suggesting a shared role in amino acid turnover and energy metabolism. A few outliers (Notch signaling, lipopolysaccharide biosynthesis) may reflect annotation noise or broad functions, but metabolism seems the core theme. ","confidence":"Medium","size":17,"edges":117,"triangles":447,"max_degree":16,"top_function":"DNA-templated transcription","members":[{"accession":"XP_004348497.1","go_terms":["GO:0006526","GO:0043171","GO:0009089","GO:0019877","GO:0006508","GO:0019878","GO:0009442","GO:0010136","GO:0006144"]},{"accession":"XP_004334124.1","go_terms":["GO:0006085","GO:0006099","GO:0006104"]},{"accession":"XP_004345970.1","go_terms":["GO:0006085","GO:0019679","GO:0019629","GO:0006099"]},{"accession":"XP_004333725.1","go_terms":["GO:0006545","GO:0006567","GO:0006570","GO:0006569","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103"]},{"accession":"XP_004335057.1","go_terms":["GO:0019596","GO:0019310","GO:0019655","GO:0090180","GO:0034077","GO:0009436","GO:0033611","GO:0000949","GO:0019529","GO:0042867","GO:0009851","GO:0000950","GO:0000951","GO:0009099","GO:0009097","GO:0032923","GO:0009234","GO:0042372","GO:0022900","GO:0006086"]},{"accession":"XP_004335315.1","go_terms":["GO:0033540","GO:0006693","GO:1904070","GO:0009791","GO:0009409","GO:0001889","GO:0042594","GO:0045329","GO:0006111","GO:0019254","GO:0051793","GO:0055007","GO:0046949","GO:0042758","GO:0018896","GO:0007507","GO:0006574","GO:0033539","GO:0006552","GO:0005978"]},{"accession":"XP_004336723.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_004336877.1","go_terms":["GO:0048873","GO:0006099","GO:0006106","GO:0006531","GO:0006108","GO:0007584","GO:0019619","GO:0009060","GO:0006189","GO:0042594","GO:0044208","GO:0001666","GO:0042450","GO:0014850"]},{"accession":"XP_004338432.1","go_terms":["GO:0043617","GO:0006086","GO:0000002","GO:0006099","GO:0006103","GO:0033512","GO:0006096","GO:0006814","GO:2001295","GO:0042759","GO:0006552","GO:0006213","GO:0006094"]},{"accession":"XP_004338590.1","go_terms":["GO:0009423","GO:0009073","GO:0019294","GO:0009103"]},{"accession":"XP_004338865.1","go_terms":["GO:0006554","GO:0009050","GO:0051454"]},{"accession":"XP_004338920.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0050689","GO:0071360","GO:0045087","GO:0008277","GO:0051301","GO:0000492","GO:0001041","GO:0070206","GO:0008653","GO:0007346","GO:0071908","GO:0071492","GO:0045070","GO:0071909","GO:0003283","GO:0051661","GO:0072189","GO:0046890","GO:0048496","GO:0050714","GO:0051348","GO:0006986","GO:0000278","GO:0045842","GO:0034454","GO:0021756","GO:0046548","GO:0060613","GO:1903546","GO:0038108","GO:0090526","GO:0003085","GO:0060296","GO:0061087","GO:0035845","GO:1903646","GO:1905515","GO:0070389","GO:1902855","GO:0070979","GO:0042787","GO:0007091","GO:0030433","GO:0006478","GO:0016570","GO:2001162","GO:0035457","GO:1903071","GO:0031145","GO:0036494","GO:0051607","GO:1902391","GO:0048312","GO:0055059","GO:0009938","GO:2000324","GO:0015979","GO:0000413","GO:0009736","GO:0035955","GO:0016576","GO:1902325","GO:1903070","GO:0010288","GO:0070301","GO:0051291","GO:2000531","GO:0071276","GO:0043278","GO:1901215","GO:0031400"]},{"accession":"XP_004341647.1","go_terms":["GO:0033320","GO:0009258","GO:0006730","GO:0009245","GO:0071951","GO:0046677","GO:0006189","GO:0006413","GO:0009103","GO:0009113","GO:0006750","GO:0070329","GO:0046892","GO:0009229","GO:0016260","GO:0009228","GO:0006541","GO:0016310"]},{"accession":"XP_004352758.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0048082","GO:0042136","GO:0048085","GO:0007615","GO:0035690","GO:0009449","GO:0051454","GO:0010259","GO:0033327","GO:0019722","GO:0071312","GO:0046684","GO:0010761","GO:0006665","GO:0015842","GO:0007623","GO:0033076","GO:0006585","GO:0006587","GO:0042412","GO:0001553","GO:2001120","GO:0071363","GO:0052314","GO:0043052","GO:0001694","GO:0006538","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103"]},{"accession":"XP_004353653.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_004333080.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0050689","GO:0071360","GO:0045087","GO:0008277","GO:0051301","GO:1903912","GO:0036494","GO:0000492","GO:0001041","GO:0070206","GO:0008653","GO:0007346","GO:0071908","GO:0071492","GO:0045070","GO:0071909","GO:0003283","GO:0051661","GO:0072189","GO:0046890","GO:0048496","GO:0050714","GO:0000160","GO:0006355","GO:0006351","GO:0051348","GO:0006986","GO:0000278","GO:0045842","GO:0034454","GO:0021756","GO:0046548","GO:0060613","GO:1903546","GO:0038108","GO:0090526","GO:0003085","GO:0060296","GO:0061087","GO:0035845","GO:1903646","GO:1905515","GO:0070389","GO:1902855","GO:0070979","GO:0042787","GO:0007091","GO:0030433","GO:0072423","GO:1903220","GO:0000464","GO:0000354","GO:0034463","GO:0098789","GO:0006378","GO:0042868","GO:0006893","GO:0000282","GO:0034221","GO:0015031","GO:0006478","GO:0016570","GO:2001162","GO:0035457","GO:1903071","GO:0031145","GO:0051607","GO:1902391","GO:2000324","GO:0015979","GO:0000413","GO:0009736","GO:0035955","GO:0016576","GO:1902325","GO:1903070","GO:0010288","GO:0070301","GO:0051291","GO:2000531","GO:0071276","GO:0043278","GO:1901215","GO:0031400","GO:0009938"]},{"accession":"XP_004339357.1","go_terms":["GO:0046188","GO:0015945","GO:0019285","GO:0055114","GO:0008203"]}],"graph":[["XP_004334124.1","XP_004333080.1",0.979],["XP_004334124.1","XP_004333725.1",0.962],["XP_004334124.1","XP_004335057.1",0.99],["XP_004334124.1","XP_004335315.1",0.684],["XP_004334124.1","XP_004336723.1",0.99],["XP_004334124.1","XP_004336877.1",0.976],["XP_004334124.1","XP_004338432.1",0.575],["XP_004334124.1","XP_004338590.1",0.878],["XP_004334124.1","XP_004338865.1",0.63],["XP_004334124.1","XP_004338920.1",0.962],["XP_004334124.1","XP_004339357.1",0.963],["XP_004334124.1","XP_004341647.1",0.979],["XP_004334124.1","XP_004345970.1",0.901],["XP_004334124.1","XP_004348497.1",0.936],["XP_004334124.1","XP_004352758.1",0.836],["XP_004334124.1","XP_004353653.1",0.875],["XP_004338590.1","XP_004333725.1",0.905],["XP_004338590.1","XP_004335057.1",0.842],["XP_004338590.1","XP_004336723.1",0.621],["XP_004338590.1","XP_004336877.1",0.766],["XP_004338590.1","XP_004339357.1",0.86],["XP_004338590.1","XP_004338432.1",0.858],["XP_004338590.1","XP_004338920.1",0.867],["XP_004338590.1","XP_004353653.1",0.855],["XP_004338590.1","XP_004352758.1",0.635],["XP_004338590.1","XP_004348497.1",0.94],["XP_004338590.1","XP_004345970.1",0.844],["XP_004336723.1","XP_004333080.1",0.976],["XP_004336723.1","XP_004333725.1",0.749],["XP_004336723.1","XP_004335057.1",0.987],["XP_004336723.1","XP_004335315.1",0.85],["XP_004336723.1","XP_004336877.1",0.937],["XP_004336723.1","XP_004338432.1",0.987],["XP_004336723.1","XP_004338865.1",0.935],["XP_004336723.1","XP_004338920.1",0.951],["XP_004336723.1","XP_004339357.1",0.982],["XP_004336723.1","XP_004341647.1",0.988],["XP_004336723.1","XP_004345970.1",0.989],["XP_004336723.1","XP_004348497.1",0.937],["XP_004336723.1","XP_004352758.1",0.851],["XP_004336723.1","XP_004353653.1",0.818],["XP_004338920.1","XP_004333725.1",0.937],["XP_004338920.1","XP_004335057.1",0.856],["XP_004338920.1","XP_004335315.1",0.963],["XP_004338920.1","XP_004336877.1",0.847],["XP_004338920.1","XP_004338432.1",0.961],["XP_004338920.1","XP_004338865.1",0.86],["XP_004338920.1","XP_004339357.1",0.859],["XP_004338920.1","XP_004341647.1",0.778],["XP_004338920.1","XP_004348497.1",0.937],["XP_004338920.1","XP_004352758.1",0.897],["XP_004338920.1","XP_004353653.1",0.818],["XP_004335057.1","XP_004333725.1",0.903],["XP_004335057.1","XP_004335315.1",0.984],["XP_004335057.1","XP_004336877.1",0.936],["XP_004335057.1","XP_004338432.1",0.966],["XP_004335057.1","XP_004338865.1",0.964],["XP_004335057.1","XP_004341647.1",0.704],["XP_004335057.1","XP_004345970.1",0.984],["XP_004335057.1","XP_004348497.1",0.991],["XP_004335057.1","XP_004352758.1",0.947],["XP_004335057.1","XP_004353653.1",0.95],["XP_004341647.1","XP_004333080.1",0.871],["XP_004341647.1","XP_004333725.1",0.865],["XP_004341647.1","XP_004336877.1",0.872],["XP_004341647.1","XP_004338432.1",0.519],["XP_004341647.1","XP_004345970.1",0.935],["XP_004341647.1","XP_004348497.1",0.652],["XP_004341647.1","XP_004352758.1",0.909],["XP_004341647.1","XP_004353653.1",0.954],["XP_004348497.1","XP_004333080.1",0.953],["XP_004348497.1","XP_004333725.1",0.63],["XP_004348497.1","XP_004335315.1",0.501],["XP_004348497.1","XP_004336877.1",0.92],["XP_004348497.1","XP_004338432.1",0.899],["XP_004348497.1","XP_004339357.1",0.978],["XP_004348497.1","XP_004345970.1",0.65],["XP_004348497.1","XP_004352758.1",0.871],["XP_004348497.1","XP_004353653.1",0.947],["XP_004333725.1","XP_004333080.1",0.986],["XP_004333725.1","XP_004336877.1",0.906],["XP_004333725.1","XP_004339357.1",0.504],["XP_004333725.1","XP_004338432.1",0.969],["XP_004333725.1","XP_004353653.1",0.874],["XP_004333725.1","XP_004352758.1",0.835],["XP_004333725.1","XP_004345970.1",0.989],["XP_004338865.1","XP_004333080.1",0.929],["XP_004338865.1","XP_004336877.1",0.599],["XP_004338865.1","XP_004339357.1",0.901],["XP_004338865.1","XP_004352758.1",0.834],["XP_004338865.1","XP_004353653.1",0.972],["XP_004353653.1","XP_004333080.1",0.777],["XP_004353653.1","XP_004335315.1",0.723],["XP_004353653.1","XP_004336877.1",0.963],["XP_004353653.1","XP_004338432.1",0.97],["XP_004353653.1","XP_004339357.1",0.962],["XP_004353653.1","XP_004345970.1",0.986],["XP_004353653.1","XP_004352758.1",0.88],["XP_004338432.1","XP_004333080.1",0.964],["XP_004338432.1","XP_004335315.1",0.928],["XP_004338432.1","XP_004336877.1",0.958],["XP_004338432.1","XP_004339357.1",0.526],["XP_004338432.1","XP_004352758.1",0.92],["XP_004338432.1","XP_004345970.1",0.988],["XP_004333080.1","XP_004335315.1",0.98],["XP_004333080.1","XP_004336877.1",0.954],["XP_004333080.1","XP_004339357.1",0.729],["XP_004333080.1","XP_004345970.1",0.808],["XP_004333080.1","XP_004352758.1",0.757],["XP_004345970.1","XP_004336877.1",0.923],["XP_004345970.1","XP_004352758.1",0.963],["XP_004352758.1","XP_004335315.1",0.668],["XP_004352758.1","XP_004336877.1",0.899],["XP_004352758.1","XP_004339357.1",0.922],["XP_004335315.1","XP_004336877.1",0.727],["XP_004335315.1","XP_004339357.1",0.964],["XP_004336877.1","XP_004339357.1",0.98]],"all_go_terms":{"GO:0006508":1,"GO:0010136":1,"GO:0009089":1,"GO:0006144":1,"GO:0006526":1,"GO:0019878":4,"GO:0043171":1,"GO:0019877":1,"GO:0009442":1,"GO:0006099":4,"GO:0006104":1,"GO:0006085":2,"GO:0019629":1,"GO:0019679":1,"GO:0009103":4,"GO:0033585":3,"GO:0019518":3,"GO:0006107":3,"GO:0007219":4,"GO:0033512":4,"GO:0042853":4,"GO:0097053":4,"GO:0019551":3,"GO:0009835":3,"GO:0006523":3,"GO:0006569":1,"GO:0009245":3,"GO:0019550":3,"GO:0006351":4,"GO:0006545":1,"GO:0032869":3,"GO:0006567":1,"GO:0055089":3,"GO:0033362":3,"GO:0006782":3,"GO:0071555":2,"GO:0000105":3,"GO:0046511":3,"GO:0046677":3,"GO:0009236":3,"GO:0009246":2,"GO:0034276":3,"GO:0042218":3,"GO:0006783":3,"GO:0006686":3,"GO:0009862":3,"GO:0006533":3,"GO:0006571":3,"GO:0006532":3,"GO:0006570":1,"GO:0009102":3,"GO:0009243":2,"GO:0015908":3,"GO:0017000":2,"GO:0019441":3,"GO:0009234":1,"GO:0000950":1,"GO:0006086":2,"GO:0009099":1,"GO:0042372":1,"GO:0009097":1,"GO:0022900":1,"GO:0090180":1,"GO:0009436":3,"GO:0034077":1,"GO:0009851":1,"GO:0032923":1,"GO:0000949":1,"GO:0019655":1,"GO:0019310":1,"GO:0019596":1,"GO:0042867":1,"GO:0033611":1,"GO:0000951":1,"GO:0019529":1,"GO:0001889":1,"GO:0005978":1,"GO:0019254":1,"GO:0046949":1,"GO:0033539":1,"GO:0042594":2,"GO:0045329":1,"GO:0006693":1,"GO:0055007":1,"GO:0006111":1,"GO:0033540":1,"GO:0018896":1,"GO:0007507":1,"GO:0006552":2,"GO:0009409":1,"GO:0006574":1,"GO:0009791":1,"GO:0042758":1,"GO:1904070":1,"GO:0051793":1,"GO:0044208":1,"GO:0006531":1,"GO:0042450":1,"GO:0019619":1,"GO:0009060":1,"GO:0014850":1,"GO:0007584":1,"GO:0006108":1,"GO:0001666":1,"GO:0006106":1,"GO:0048873":1,"GO:0006189":2,"GO:0000002":1,"GO:0006094":1,"GO:0006103":1,"GO:0006814":1,"GO:0042759":1,"GO:2001295":1,"GO:0006096":1,"GO:0043617":1,"GO:0006213":1,"GO:0019294":1,"GO:0009073":1,"GO:0009423":1,"GO:0009050":1,"GO:0051454":2,"GO:0006554":1,"GO:0006986":2,"GO:0038108":2,"GO:0045842":2,"GO:1905515":2,"GO:0045087":2,"GO:0007091":2,"GO:0016570":2,"GO:2000324":2,"GO:0030850":2,"GO:0051301":2,"GO:0051348":2,"GO:0090526":2,"GO:1903646":2,"GO:0048312":1,"GO:0015979":2,"GO:0000278":2,"GO:0036494":2,"GO:0035845":2,"GO:0031400":2,"GO:0008653":2,"GO:0050689":2,"GO:0034454":2,"GO:0030433":2,"GO:2000531":2,"GO:0072189":2,"GO:0046890":2,"GO:0035457":2,"GO:0071360":2,"GO:0071276":2,"GO:0051661":2,"GO:0046548":2,"GO:0007346":2,"GO:0045070":2,"GO:0060613":2,"GO:1903546":2,"GO:0000413":2,"GO:0051291":2,"GO:1902855":2,"GO:0009938":2,"GO:0009736":2,"GO:0046661":2,"GO:0055059":1,"GO:1902325":2,"GO:0000492":2,"GO:0042787":2,"GO:0070206":2,"GO:0070301":2,"GO:0010288":2,"GO:0070979":2,"GO:0008277":2,"GO:1902391":2,"GO:0031145":2,"GO:0006463":2,"GO:0060296":2,"GO:0003085":2,"GO:0071909":2,"GO:0070389":2,"GO:1901215":2,"GO:0003283":2,"GO:0016576":2,"GO:0001041":2,"GO:2001162":2,"GO:0061087":2,"GO:0006478":2,"GO:0021756":2,"GO:0051607":2,"GO:0048496":2,"GO:0071492":2,"GO:0035955":2,"GO:0050714":2,"GO:1903070":2,"GO:1903071":2,"GO:0071357":2,"GO:0071908":2,"GO:0043278":2,"GO:0033320":1,"GO:0006750":1,"GO:0009228":1,"GO:0016310":1,"GO:0006541":1,"GO:0009258":1,"GO:0046892":1,"GO:0009113":1,"GO:0071951":1,"GO:0016260":1,"GO:0006730":1,"GO:0006413":1,"GO:0070329":1,"GO:0009229":1,"GO:0006546":2,"GO:0071312":1,"GO:0006538":1,"GO:0043420":2,"GO:0043052":1,"GO:0001553":1,"GO:0006587":1,"GO:0046724":2,"GO:0034354":2,"GO:0009449":1,"GO:0006585":1,"GO:0006665":1,"GO:2001120":1,"GO:0001694":1,"GO:0042412":1,"GO:0051384":2,"GO:0071363":1,"GO:0019265":2,"GO:0019700":2,"GO:0019805":2,"GO:0042866":2,"GO:0010761":1,"GO:0019722":1,"GO:0044571":2,"GO:0018283":2,"GO:0006564":2,"GO:0070903":2,"GO:0008615":2,"GO:0007623":1,"GO:0033076":1,"GO:0019442":2,"GO:0015842":1,"GO:0033327":1,"GO:0048085":1,"GO:0046684":1,"GO:0052314":1,"GO:0010259":1,"GO:0034516":2,"GO:0035690":1,"GO:0007615":1,"GO:0051591":2,"GO:0019448":2,"GO:0042136":1,"GO:0048082":1,"GO:0000160":1,"GO:0000354":1,"GO:0034221":1,"GO:0015031":1,"GO:1903912":1,"GO:0098789":1,"GO:1903220":1,"GO:0034463":1,"GO:0072423":1,"GO:0006893":1,"GO:0000464":1,"GO:0000282":1,"GO:0006378":1,"GO:0042868":1,"GO:0006355":1,"GO:0046188":1,"GO:0019285":1,"GO:0008203":1,"GO:0015945":1,"GO:0055114":1},"recipe_readded":[]}