[{"hash":"488589682567759438","title":"Proliferation and ER-Golgi trafficking","description":"The top GO terms converge on cell growth, mitosis, and cell division, plus COPII-ER/Golgi vesicle trafficking and other secretory pathway steps, pointing to a proliferating cell state that relies on membrane trafficking to support division and growth. A minority of terms touches immune development (beta selection) and GTPase regulation, but the core signal is proliferation paired with secretory transport.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0008283","count":7},{"id":"GO:0090114","count":6},{"id":"GO:0090307","count":6}]},{"hash":"2202900449713646157","title":"Embryonic Development and Organogenesis","description":"The terms cluster around broad developmental and morphogenetic processes across multiple tissues (brain, inner ear, placenta/trophoblast, cartilage) including EMT and endothelial barrier establishment, indicating a general embryonic development/organogenesis theme rather than a single pathway.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0007626","count":6},{"id":"GO:0003323","count":5}]},{"hash":"1815452495300893456","title":"Cardiovascular Development and Endothelial Differentiation","description":"The top terms are dominated by heart-related processes: cardiac right atrium morphogenesis, Notch signaling in heart field cardioblast proliferation, and venous endothelial cell differentiation, along with mechanotransduction (cellular response to mechanical stimulus). These strongly point to a shared theme of heart development and vascular differentiation, with a few more general terms. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0003213","count":4},{"id":"GO:0033280","count":4},{"id":"GO:0003270","count":4},{"id":"GO:0060843","count":4}]},{"hash":"1970373920545877151","title":"Vesicle trafficking and signaling regulation","description":"The top GO terms point to membrane trafficking processes (ER-Golgi transport, endocytosis, synaptic vesicle priming) and regulation of signaling pathways (Rho, Ras), with a brain development angle, suggesting a cluster of proteins involved in vesicle movement and modulation of signaling, across neural and non-neural contexts. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0006888","count":5},{"id":"GO:0048260","count":4},{"id":"GO:0016082","count":4},{"id":"GO:0010796","count":4}]},{"hash":"1754101929994876198","title":"Skeletal muscle development and neural signaling","description":"This cluster centers on skeletal muscle fiber development and transitions between fast and slow fiber types, with neural activity evident from excitatory postsynaptic potential terms. The presence of genes related to muscle maturation (skeletal muscle fiber development, transition between fast and slow fiber) and neural signaling (excitatory postsynaptic potential, response to cocaine) suggests coordination of muscle-Nervous system communication. Additional terms about lipid metabolism (sphingomyelin catabolism, mevalonate pathway regulation) and immune regulation (T cell homeostasis) appear less dominant, indicating broader cellular metabolism alongside the core muscle-neural theme.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006685","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0048741","count":3}]},{"hash":"1035811606448434285","title":"Mitochondrial dynamics and cell cycle regulation","description":"The terms center on mitochondria (fission, distribution, membrane organization) and core cell cycle processes (cell division, cell cycle), suggesting a functional cluster where mitochondrial dynamics are coordinated with cell proliferation. Additional signals (Rho-regulated cytoskeleton signaling) and proteostasis responses (unfolded protein response) reinforce a theme of coordinated growth and mitochondrial organization during division; nervous system development appears ancillary. Overall, this points to a mitochondrial dynamics\u2013coupled cell cycle program.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:2000324","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0000266","count":2},{"id":"GO:0048312","count":2}]},{"hash":"1382150041486194379","title":"Neuronal adhesion and synapse assembly","description":"This cluster is dominated by GO terms related to neurons and synapses: positive regulation of synapse assembly, synapse assembly, and nervous system development, along with cell-cell adhesion (homophilic and heterophilic). Additional terms point to neuronal differentiation and guidance, such as serotonergic neuron axon guidance and inner ear receptor cell stereocilium organization. Together, these terms suggest a role in establishing neuronal connectivity and synaptic contacts during neural development, hence the label Neuronal adhesion and synapse assembly.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0007399","count":9},{"id":"GO:0007156","count":9},{"id":"GO:0007416","count":8}]},{"hash":"1300900321926262946","title":"Neural Development and Signaling","description":"This cluster is dominated by GO terms related to nervous system development, dendrite morphogenesis, and neuronal function (nervous system development, dendrite morphogenesis, potassium ion transport), complemented by key developmental signaling pathways (canonical Wnt and Hippo signaling) and transcriptional regulation, suggesting a cohesive role in neurodevelopment and associated signaling processes.","confidence":"High","size":28,"edges":4,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":11},{"id":"GO:0007275","count":11},{"id":"GO:0006351","count":11},{"id":"GO:0090263","count":10},{"id":"GO:0048813","count":10}]},{"hash":"1046712454249960805","title":"Mitotic Chromosome Segregation & Centromere Assembly","description":"The cluster is dominated by terms related to mitosis and chromosome organization: mitotic cell cycle, cell division, CENP-A containing chromatin assembly, microtubule severing, and histone acetylation, all of which point to centromere function, spindle dynamics, and chromatin remodeling during cell division. Additional terms about protein interactions and ER-to-Golgi trafficking may reflect shared components in cellular organization, but the strongest signal is mitotic chromosome segregation machinery.","confidence":"High","size":28,"edges":93,"triangles":160,"max_degree":27,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0070208","count":7},{"id":"GO:0030900","count":7},{"id":"GO:0051260","count":6}]},{"hash":"1683919011026225033","title":"Mitotic Cell Cycle Regulation","description":"The top terms cluster around mitosis-related processes\u2014positive regulation of mitotic cell cycle transition, regulation of spindle pole body separation, and APC/C-dependent catabolic processes\u2014suggesting a shared theme of cell-cycle control during mitosis. Other terms like Wnt signaling, TNF signaling, and stress responses appear more peripheral, possibly reflecting broader or multifunctional annotations. Overall, the dominant mitotic theme justifies the label, though the presence of unrelated terms warrants a moderate confidence level.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051437","count":1},{"id":"GO:0033601","count":1},{"id":"GO:0010696","count":1},{"id":"GO:0031145","count":1},{"id":"GO:0033209","count":1}]},{"hash":"26730344783241655","title":"Core Gene Expression Machinery with Metabolism","description":"This cluster is dominated by GO terms for translation and transcription, indicating a core gene-expression module. The co-occurrence of metabolism-related terms (TCA cycle, malonyl-CoA, carbamoyl phosphate biosynthesis) and signaling cues (growth hormone response, cellular response to cAMP) suggests these proteins couple expression machinery with basic metabolic and regulatory pathways.","confidence":"Medium","size":28,"edges":50,"triangles":122,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0006351","count":3},{"id":"GO:0060416","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0055081","count":2}]},{"hash":"1292493549844284682","title":"Chromatin silencing and genome maintenance","description":"This cluster is dominated by terms related to heterochromatin formation (including silent mating-type cassette and subtelomeric regions), DNA replication, and cell cycle regulation, with associated processes like break-induced replication and transcriptional repression. Additional terms point to ribosome biogenesis and protein turnover, suggesting links between chromatin state, genome stability, and cell growth. Taken together, the proteins likely function in chromatin-mediated genome maintenance and cell-cycle control, rather than a single, narrow pathway. ","confidence":"High","size":28,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030466","count":8},{"id":"GO:0006260","count":7},{"id":"GO:0007049","count":7},{"id":"GO:0006348","count":7},{"id":"GO:0000122","count":7}]},{"hash":"358429158061789697","title":"Unknown","description":"The GO terms span diverse processes\u2014from central metabolism (TCA cycle, glycolysis, alanine and lysine-related catabolic/biosynthetic processes) to biosynthesis pathways (biotin, porphyrin biosynthesis) and even translation and Notch signaling\u2014without a clear, single functional theme uniting the proteins. This broad mix suggests no cohesive cluster function can be assigned with confidence.","confidence":"","size":28,"edges":167,"triangles":545,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":6},{"id":"GO:0006412","count":6},{"id":"GO:0042853","count":4},{"id":"GO:0007219","count":4},{"id":"GO:0006096","count":3}]},{"hash":"865967791015664620","title":"Mitotic cell cycle and DNA replication","description":"This cluster is dominated by GO terms tied to DNA replication and mitosis, including DNA replication, mitotic sister chromatid separation, mitotic metaphase chromosome alignment, and the mitotic cell cycle, indicating a cohesive group of proteins involved in chromosome segregation and genome duplication. Additional terms like mRNA export and stress responses are present but appear ancillary to the core mitotic/DNA replication theme. High confidence that the label reflects the main function of the cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006406","count":7},{"id":"GO:0006260","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0051306","count":5},{"id":"GO:0007080","count":5}]},{"hash":"2249686703407383961","title":"Nuclear import and cell cycle regulators","description":"The cluster is enriched for GO terms related to import of NLS-bearing and ribosomal proteins into the nucleus, along with cell division, and regulation of kinase and phosphatase activities. While some terms (ciliary docking, viral process, extrinsic apoptotic signaling) are broader, the dominant theme ties nuclear transport with cell cycle signaling and regulation.","confidence":"Medium","size":28,"edges":11,"triangles":1,"max_degree":5,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0006610","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0071230","count":6}]},{"hash":"447284272841941211","title":"Spliceosome-Mediated mRNA Splicing and Export","description":"This cluster centers on mRNA processing and splicing by the spliceosome, with several terms for regulation of splicing, spliceosome assembly, and mRNA export, plus stress-related mRNA stability regulation, indicating a cohesive group of RNA processing factors.","confidence":"High","size":27,"edges":350,"triangles":2900,"max_degree":26,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":16},{"id":"GO:0000398","count":13},{"id":"GO:0031047","count":12},{"id":"GO:0048026","count":12},{"id":"GO:0006378","count":10}]},{"hash":"1967573524536913715","title":"Embryonic and organ morphogenesis","description":"The top GO terms point to developmental and morphogenetic processes across multiple tissues (brain, heart, eye, placenta, prostate, habenula, etc.), suggesting these proteins participate in broad embryonic development rather than a single tissue-specific pathway. Locomotory behavior also hints at nervous system development involvement.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007626","count":10},{"id":"GO:0007420","count":9},{"id":"GO:0048839","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0007507","count":9}]},{"hash":"2199063365553755442","title":"Mitotic Cell Cycle Regulation and Ubiquitination","description":"The dominant GO terms point to mitosis (metaphase/anaphase transition, mitotic cell cycle, cell division) and ubiquitin-dependent regulation (K11-linked ubiquitination), indicating a cluster centered on mitotic control and protein modification, with some related but secondary processes like protein folding and snoRNP assembly.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007091","count":10},{"id":"GO:0000278","count":10},{"id":"GO:0051301","count":10},{"id":"GO:0070979","count":10},{"id":"GO:0071276","count":10}]},{"hash":"835087391336730281","title":"Translation initiation and mRNA regulation","description":"The top GO terms cluster around translation initiation, reinitiation, preinitiation complex formation, and IRES-dependent initiation, with additional signals of RNA processing and mRNA stability regulation in stress. This points to a group of proteins involved in controlling translation and RNA metabolism rather than a single enzymatic pathway, warranting a label focused on translation initiation and mRNA regulation.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0048026","count":11},{"id":"GO:0031047","count":10},{"id":"GO:0006378","count":10}]},{"hash":"1437887039659170963","title":"Mitotic Cell Cycle and DNA Repair","description":"This cluster is dominated by GO terms tied to mitosis, kinetochore localization, DNA replication and DNA repair, with strong representation for G1/S transition and chromosome maintenance. While a few terms relate to neuronal or immune contexts, the core signal points to chromosome segregation and genome integrity during cell division, justifying a cohesive mitosis/DNA maintenance label.","confidence":"High","size":27,"edges":101,"triangles":131,"max_degree":14,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034501","count":20},{"id":"GO:0071276","count":20},{"id":"GO:0000278","count":20},{"id":"GO:0006281","count":20},{"id":"GO:0006260","count":20}]},{"hash":"1628864071752087040","title":"TORC1 signaling, ribosome biogenesis, and nucleocytoplasmic transport","description":"The terms point to nutrient-/growth signaling via TORC1, increased ribosome biogenesis, and multiple transport processes (mRNA export, nuclear pore assembly, nuclear envelope dynamics, ER-Golgi trafficking). The presence of GTPase regulation and serine dephosphorylation supports coordinated signaling, linking growth control with protein production and intracellular trafficking. This suggests a cohesive theme around growth signaling and nucleocytoplasmic transport, with ribosome production as a connected process.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0070262","count":3},{"id":"GO:0038202","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0071230","count":3}]},{"hash":"1855032622233459449","title":"Dopamine/Adrenergic GPCR Signaling in Retina and Heart","description":"The top GO terms point to GPCR-driven signaling cascades, including dopamine and adrenergic receptor pathways that activate adenylate cyclase and phospholipase C, and regulate GTPase activity and phosphatidylinositol biosynthesis. The inclusion of phototransduction and retina development indicates retina-specific GPCR signaling, while heart development suggests broader tissue relevance. Collectively, the cluster appears to comprise proteins involved in GPCR-mediated signaling and downstream cAMP/IP3-DAG pathways across retina and heart contexts. High","confidence":"","size":27,"edges":235,"triangles":1161,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":26},{"id":"GO:0060158","count":24},{"id":"GO:0043950","count":24},{"id":"GO:0007191","count":24},{"id":"GO:0071880","count":24}]},{"hash":"2066608379689360443","title":"Fungal Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for ribosome biogenesis, rRNA maturation, and cytoplasmic translation, indicating core involvement in ribosome assembly and protein synthesis in fungi. Additional terms reflect fungal-type cell wall biogenesis and related biosynthetic processes (mannoprotein and glycogen biosynthesis), suggesting some members also participate in cell wall and carbohydrate metabolism. Overall, the dominant signal is ribosome biogenesis/translation with secondary associations to fungal cell wall biosynthesis.","confidence":"Medium","size":27,"edges":9,"triangles":4,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0000902","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0000466","count":3}]},{"hash":"1024620964300000475","title":"Muscle development and cardiac electrical activity","description":"The terms cluster around muscle formation and function, including muscle cell and neuromuscular junction development, and cardiac electrical activity such as cardiac muscle cell action potentials, His bundle depolarization, and high-voltage\u2013gated calcium channel\u2013related calcium transport. Although a couple terms (like obsolete glycosylation) are less informative, the dominant theme ties muscle development to excitation-contraction signaling in cardiac and neuromuscular contexts.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0075015","count":2},{"id":"GO:0010493","count":2},{"id":"GO:0048747","count":1},{"id":"GO:0007528","count":1}]},{"hash":"1181349260949919134","title":"Cardiac development and electrophysiology","description":"The dominant GO terms describe heart formation (left ventricle morphogenesis, outflow tract morphogenesis, atrial SA node regulation) and cardiac muscle electrical activity (regulation of action potential, calcium release from the sarcoplasmic reticulum), indicating a cohesive theme around heart development and excitation-contraction mechanics. Some non-cardiac development terms appear, but the strongest signal centers on cardiac structure and function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":10},{"id":"GO:0043931","count":9},{"id":"GO:0003151","count":9},{"id":"GO:0098907","count":8},{"id":"GO:0003220","count":8}]},{"hash":"814224149353909725","title":"Ribosome Biogenesis and Translation with Cell Cycle","description":"This cluster is dominated by GO terms for ribosome biogenesis and translation (cytoplasmic translation, ribosome biogenesis, ribosomal subunit export) together with cell-cycle processes (cell division, cell cycle). This points to a theme of protein-synthesis machinery operating during proliferative growth; a few terms on septum assembly and conjugation suggest bacterial cytokinesis, but the core signal is ribosome biogenesis and translation linked to cell-cycle progression.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":6},{"id":"GO:0006412","count":6},{"id":"GO:0042274","count":4},{"id":"GO:0090529","count":4}]},{"hash":"2189703821878154644","title":"Neural axon guidance and adhesion","description":"Cluster is enriched for neuronal development and axon guidance terms (motor neuron axon guidance, retinal ganglion cell axon guidance, peripheral nervous system neuron axonogenesis) and related cell-matrix adhesion, suggesting a neural connectivity module.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008045","count":6},{"id":"GO:0055114","count":5},{"id":"GO:2000324","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0070527","count":4}]},{"hash":"596984442248417370","title":"Steroid and lipid biosynthesis","description":"The top GO terms cluster around biosynthetic processes for steroids (testosterone, glucocorticoids, androgens) and various lipids (retinoids, sphingolipids, fatty acids), plus related metabolite biosynthesis like poly-hydroxybutyrate. This suggests a cohesive theme of diverse metabolite biosynthesis, especially steroid and lipid pathways, despite some outlier terms.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0061370","count":1},{"id":"GO:0017000","count":1},{"id":"GO:0042574","count":1},{"id":"GO:0006704","count":1}]},{"hash":"994511639531188050","title":"RNA splicing and translation regulation","description":"The cluster centers on RNA processing and gene expression control, as shown by spliceosome conformational change (GO:0000388), translational frameshifting (GO:0006452), and regulation of protein export from the nucleus (GO:0046825). While there are a few meiosis-related terms (spermatogenesis, chiasma assembly) and a heat/stress signal in the mix, the strongest, most coherent theme is RNA splicing and translation regulation. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046825","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0007283","count":1},{"id":"GO:0090084","count":1},{"id":"GO:0051026","count":1}]},{"hash":"128104884757650093","title":"Synaptic vesicle exocytosis and SNARE assembly","description":"The GO terms point to neuronal synaptic functions: calcium-regulated neurotransmitter exocytosis, SNARE complex assembly, vesicle priming and fusion at the presynaptic membrane, and related synaptic processes, with supporting terms like axonogenesis and transcriptional activity. While secretory terms like histamine and growth hormone secretion appear, the dominant signal is presynaptic vesicle release machinery and synaptic plasticity. This suggests the cluster reflects components of the neurotransmitter release apparatus and related synaptic development pathways.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0048172","count":1},{"id":"GO:0007409","count":1},{"id":"GO:0016082","count":1},{"id":"GO:0048791","count":1}]},{"hash":"117331883416788013","title":"Neuronal vesicle trafficking and axonal transport","description":"The cluster centers on neural transport processes: synaptic vesicle maturation, endosome-to-lysosome transport, and intracellular transport, with additional hints of retrograde axonal transport and neural morphogenesis, indicating a coordinated vesicle trafficking program in neurons.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016188","count":2},{"id":"GO:0008333","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0030035","count":1}]},{"hash":"516550942110902248","title":"RNA processing and translational regulation","description":"These proteins cluster around RNA metabolism (mRNA processing, splicing, polyadenylation) and translation control (formation of the preinitiation complex, translation reinitiation, IRES-dependent initiation, viral translation termination-reinitiation). The dominant signal is RNA processing together with regulation of translation, with transcription and growth terms present but less central. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0006446","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0035264","count":2}]},{"hash":"1121184935273620295","title":"Cardiac Development and Muscle Signaling","description":"This cluster is characterized by GO terms tied to heart development and regulation of cardiac muscle activity, including heart rate control and electrical signaling (ventricular repolarization, atrial depolarization). While a few terms such as bone ossification and Fc-epsilon receptor signaling appear, the predominant theme is cardiac development and signaling pathways.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903244","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0038095","count":4}]},{"hash":"1404621101519112123","title":"Cellular stress response and secretory pathway regulation","description":"The top GO terms cluster around stress responses (heat/cold), redox/homeostasis, and modulation of signaling (negative regulation of protein kinase activity), with processes in the secretory pathway (ER-to-Golgi transport) and gene expression (transcription, mRNA processing). This suggests a cohesive theme of stress management via signaling and protein trafficking.","confidence":"Medium","size":26,"edges":19,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0006351","count":2}]},{"hash":"388274902100176985","title":"Vertebrate embryonic brain and eye morphogenesis","description":"This cluster is dominated by terms tied to embryonic development of neural/ocular structures\u2014eye morphogenesis (embryonic/ camera-type eye development), brain segmentation, and hindbrain patterning (rhombomere development, habenula development)\u2014along with related organ morphogenesis processes, suggesting a cohesive vertebrate neural/eye developmental program. Transcription by RNA polymerase II reflects active gene expression in these developmental contexts.","confidence":"High","size":26,"edges":245,"triangles":1128,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":14},{"id":"GO:0006366","count":13},{"id":"GO:0060441","count":11},{"id":"GO:0003148","count":11},{"id":"GO:0001890","count":11}]},{"hash":"98821289202772061","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060743","count":2},{"id":"GO:0010801","count":2},{"id":"GO:0051225","count":2}]},{"hash":"186974645349007233","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"Reasoning: The cluster is enriched for lamellipodium assembly, actin cytoskeleton organization, and cell migration, with supporting terms for microtubule organization and centrosome localization, indicating coordinated cytoskeletal remodeling that drives motility and morphogenesis; AKT signaling and cilium-related localization point to regulatory layers atop this core function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0009887","count":2},{"id":"GO:0097150","count":1}]},{"hash":"1536178481399561241","title":"Transcriptional Regulation and Signaling Modulators","description":"The top terms show enrichment for DNA-templated transcription regulation, various signaling pathways (Rho, cAMP, cyclic nucleotide biosynthesis), and processes tied to cell fate and neuronal structure (apoptosis, dendritic spine morphogenesis), suggesting the proteins collectively modulate gene expression and cellular signaling. Confidence in a cohesive theme is moderate due to functional diversity across terms.","confidence":"Medium","size":26,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0046827","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0009190","count":3}]},{"hash":"1869205615105214461","title":"Chromatin modification and ribosome biogenesis","description":"The top GO terms cluster around histone methylation (H3-K4, H3-K79), DNA-templated transcription, and ribosome biogenesis including rRNA maturation, suggesting a nuclear program coordinating chromatin state, transcriptional activity, and ribosome production. While other terms touch on growth and signaling, the dominant theme is chromatin regulation linked to gene expression and ribosome assembly.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051568","count":4},{"id":"GO:0032933","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0090307","count":4}]},{"hash":"1701023931641114251","title":"Broad-Spectrum Membrane Transporters","description":"The cluster is dominated by diverse transmembrane transport GO terms, including potassium, sodium, phosphate, xenobiotic, vitamin, and sugar/ion transport, plus related metabolic associations. This pattern indicates a group of proteins functioning as membrane transporters with broad substrate specificity rather than a unitary pathway, giving a cohesive label of broad-spectrum transmembrane transporters.","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":7},{"id":"GO:0006855","count":6},{"id":"GO:0035461","count":6},{"id":"GO:0035435","count":6},{"id":"GO:0035725","count":5}]},{"hash":"1699720173553882730","title":"Unknown","description":"The top GO terms span translation, mitochondrial protein import, photosynthesis, redox metabolism, development, tRNA modification, cofactor biosynthesis, and signal-related dephosphorylation, indicating a mix of general cellular processes rather than a single shared function. Because there isn\u2019t a clear, cohesive theme tying all proteins together, a concise thematic label cannot be confidently assigned.","confidence":"","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0030150","count":3},{"id":"GO:0019684","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0030855","count":2}]},{"hash":"591475405176936843","title":"Ribosome biogenesis and rRNA processing","description":"The GO terms are dominated by rRNA maturation (LSU/SSU), ribosome biogenesis, and ribosome assembly, with related rRNA and tRNA methylation steps and mitochondrial translation regulation. This cohesive set points to a cluster of proteins involved in ribosome assembly and RNA maturation processes.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0006355","count":1},{"id":"GO:0070475","count":1}]},{"hash":"193905048955707127","title":"Immune phagocytosis with actin remodeling","description":"This cluster centers on GO terms for phagocytosis, adaptive immune response, mast cell proliferation, and actin cytoskeleton dynamics (barbed-end capping, ruffle assembly, membrane invagination), pointing to immune cells engaging in engulfment and membrane remodeling. While heart development and insulin signaling appear among the terms, the dominant theme is immune cell\u2013mediated phagocytosis with actin-driven cytoskeletal changes, suggesting functional cohesion around immune activation and phagocytic processes.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0006909","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0000350","count":2}]},{"hash":"1208900134792506842","title":"Vesicle trafficking and mitotic exit","description":"The top GO terms cluster around endomembrane transport (ER\u2013Golgi trafficking, endosome transport, multivesicular body sorting, Cvt/vacuole targeting) and cell cycle progression (exit from mitosis) with additional notes on GTPase activity regulation and protein localization to membranes. This points to a cohesive function: proteins coordinating vesicle trafficking and distribution during and after mitosis, with some autophagy-related trafficking connections. ","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0071985","count":4},{"id":"GO:0010458","count":4}]},{"hash":"339283823745416729","title":"Chromatin modification and gene expression regulation","description":"The cluster shows enrichment for DNA-templated transcription, translation initiation and reinitiation, and histone H3 acetylation/methylation regulation, along with cell cycle and telomere maintenance terms, indicating a cohesive theme around regulation of gene expression at transcriptional and translational levels, linked to chromatin state and genome stability; the heat response term also suggests stress-responsive regulation.","confidence":"Medium","size":25,"edges":36,"triangles":12,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0048705","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0043966","count":5}]},{"hash":"2071203860280571476","title":"GPCR-Mediated Signaling and Ca2+/cAMP Regulation","description":"The cluster centers on GO terms tied to GPCR signaling and downstream second messengers: activation of adenylate cyclase (cAMP), regulation of Ca2+ release, neurotransmitter secretion, opsin-mediated signaling, amphetamine response, and regulation of cardiac muscle contraction. These all reflect GPCR-driven pathways that control neuronal/photoreceptor signaling and heart rate, with some general outcomes on apoptosis and cell proliferation. Confidence: High","confidence":"High","size":25,"edges":50,"triangles":45,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0043065","count":3},{"id":"GO:0007190","count":3},{"id":"GO:0051281","count":3},{"id":"GO:0007269","count":3},{"id":"GO:0006468","count":3}]},{"hash":"1090987339145372299","title":"Unknown","description":"The top GO terms are highly diverse and include epithelial polarity, muscle stretch response, salicylic acid signaling, telomere maintenance, dendrite development, thermoception, and more, with several terms obsolete. There is no single coherent process that ties these terms together, suggesting a mixed or non-specific set of functions for the cluster. ","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":7},{"id":"GO:0035994","count":7},{"id":"GO:0032088","count":7},{"id":"GO:0071446","count":6},{"id":"GO:0032212","count":6}]},{"hash":"1509791698814481590","title":"Ubiquitin-driven mitotic protein degradation","description":"This cluster is dominated by ubiquitin-proteasome\u2013related processes (SCF-dependent and K11-linked ubiquitination, APC/C-dependent degradation) and mitotic cell cycle terms (G2/M transition, mitosis, cell division), suggesting a cohesive theme of controlled proteolysis during cell division. Some related terms like repair and viral processes may be broader contexts, but the central signal points to mitotic proteolysis.","confidence":"High","size":25,"edges":245,"triangles":1312,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":18},{"id":"GO:0070979","count":16},{"id":"GO:0000086","count":16},{"id":"GO:0000278","count":15},{"id":"GO:0070911","count":14}]},{"hash":"335126597619826805","title":"Synaptic plasticity and neuronal signaling","description":"Cluster enriched for neuronal signaling and synaptic plasticity terms (long-term synaptic depression, regulation of excitatory postsynaptic potential, dendritic spine morphogenesis, synapse structural plasticity) and behavior-related terms (sound perception, vocalization, social behavior), indicating a neuron- and synapse-focused group. Minor epithelial polarity terms may be incidental.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060292","count":6},{"id":"GO:0007605","count":6},{"id":"GO:2000463","count":6},{"id":"GO:0071625","count":6},{"id":"GO:0035176","count":6}]},{"hash":"2078404801472170708","title":"Ribosome biogenesis and RNA processing","description":"The cluster is dominated by GO terms related to ribosome biogenesis, rRNA maturation, and various RNA processing/modification activities (splicing, methylation), indicating a core nucleolar/nuclear function focused on assembling ribosomes and processing RNA. Some terms are peripheral (mitosis, retina development), but the strongest signal centers on ribosome production and RNA maturation. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006890","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0034316","count":8},{"id":"GO:2001162","count":7},{"id":"GO:0000466","count":7}]},{"hash":"1026236960474875242","title":"Biosynthesis and Metabolism Cluster","description":"The top GO terms are dominated by biosynthetic processes (antibiotic, biotin, cobalamin) and catabolic/metabolic processes (uracil catabolic, stilbene catabolic, nitrogen utilization), with additional stress and dormancy\u2013related terms. The lack of edges indicates this is a loose collection of metabolic functions rather than a single pathway, so the label emphasizes an overall metabolic/biosynthesis theme rather than a specific function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0006212","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0006950","count":4},{"id":"GO:0085014","count":4}]},{"hash":"588015572945670054","title":"Angiotensin signaling and peptide regulation","description":"The cluster\u2019s GO terms strongly point to the renin-angiotensin axis (angiotensin maturation; regulation of blood volume by renin-angiotensin) and angiotensin-related behaviors (drinking behavior), indicating a hormonal/peptide regulation theme. Additional terms about peptide processing (amyloid precursor protein biosynthesis, amyloid-beta metabolism) and immune peptide handling (antigen processing via MHC II, antibacterial peptide regulation) suggest broader peptide-regulation roles. Overall, the dominant signal appears to be angiotensin-mediated hormonal control with related peptide processing, hence this label.","confidence":"Medium","size":25,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0002814","count":3},{"id":"GO:0002803","count":3},{"id":"GO:0002003","count":3}]},{"hash":"1064578506978549563","title":"LPS-driven lung inflammation and epithelial response","description":"This cluster shows multiple GO terms tied to inflammatory responses in the lung, including response to lipopolysaccharide, chronic inflammatory response, and lung development. The presence of receptor internalization and smooth septate junction assembly points to airway epithelial barrier dynamics, while regulation of cell motility and NF-kappaB signaling suggests modulation of immune signaling. Although visual perception is listed, the dominant theme is pulmonary inflammatory response and epithelial function, indicating a coherent lung-immune cluster with epithelial involvement.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:0002544","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0031623","count":1}]},{"hash":"1243504015072467970","title":"Cell Cycle and Cytoskeleton Regulation","description":"Top GO terms point to centrosome duplication and meiotic cell cycle, together with actin cytoskeleton organization and Golgi localization, suggesting these proteins coordinate cell division with intracellular organization and trafficking rather than a single, narrow function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050729","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0051298","count":2},{"id":"GO:0051321","count":2},{"id":"GO:0051895","count":1}]},{"hash":"127680458468313682","title":"Synaptic development and actin remodeling","description":"The terms point to neuronal synapse formation and regulation (excitatory postsynaptic potential, negative regulation of glutamatergic transmission) and cytoskeletal dynamics via Arp2/3-mediated actin nucleation and GTPase signaling, with supplementary hints of development and proliferation. Together, they suggest a cluster centered on synaptic development and actin-driven remodeling. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0007275","count":3},{"id":"GO:2000601","count":3},{"id":"GO:0006468","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1973390025556282714","title":"Neural development and synaptic function","description":"The top terms cluster around nervous system development and synaptic activity, including visual perception, axonogenesis, Schwann cell development, and excitatory postsynaptic potential. While some terms relate to angiogenesis and heart development, the strongest and most consistent signals are neural-development and synaptic function, supporting a neural-focused label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":14},{"id":"GO:0014044","count":14},{"id":"GO:0009738","count":14},{"id":"GO:0010800","count":14},{"id":"GO:0000086","count":14}]},{"hash":"1705026906228098604","title":"Organellar Translation and Energy Metabolism","description":"This cluster is dominated by translation-related terms (translation, tRNA aminoacylation, regulation of translational fidelity) and energy/metabolism terms (mitochondrial electron transport, photosynthesis, proton transport), suggesting proteins involved in organellar protein synthesis and energy production (in mitochondria and chloroplasts). Confidence in this label is Medium.","confidence":"Medium","size":24,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:1902600","count":3},{"id":"GO:0006122","count":3},{"id":"GO:0006810","count":3},{"id":"GO:0019684","count":3}]},{"hash":"589317667962279144","title":"Gonadal development and chromatin regulation","description":"The cluster is dominated by terms related to male reproductive development (Sertoli cell development, male gonad development, gamete generation) and transcriptional/epigenetic control (DNA-templated transcription, chromatin remodeling, histone methylation, DNA methylation). Some terms about atrial septum morphogenesis and cytokinin signaling appear as likely annotation noise or distant connections, but the core signal points to gonadal differentiation governed by chromatin and transcriptional regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009736","count":3},{"id":"GO:0046661","count":3},{"id":"GO:0003290","count":2},{"id":"GO:0003289","count":2},{"id":"GO:0043046","count":2}]},{"hash":"904653595223516049","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0051301","count":2}]},{"hash":"2251744504692875527","title":"DNA Replication and Repair Core","description":"The top terms are dominated by DNA replication, DNA-templated transcription, DNA repair, and mitotic cell cycle, pointing to a core nuclear machinery module for genome maintenance and cell division. The additional development and neural terms are present but less frequent, making the DNA processing theme the most representative for this cluster.","confidence":"High","size":24,"edges":46,"triangles":16,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0006281","count":5},{"id":"GO:0048701","count":4},{"id":"GO:0070671","count":4}]},{"hash":"584250691005437979","title":"Wnt-driven mammary gland development and proliferation","description":"Top GO terms indicate transcription regulation, cell cycle control, and mammary gland biology (lactation, mammary gland epithelial cell proliferation) with canonical Wnt signaling. This points to a theme of coordinating mammary gland development and proliferation through Wnt-mediated transcription and cell-cycle progression.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0045737","count":4},{"id":"GO:0007595","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0000082","count":3}]},{"hash":"964239509986899736","title":"Transcription and ribosome biogenesis with RNA processing","description":"The cluster is dominated by GO terms for DNA-templated transcription, ribosome biogenesis, and formation of the translation preinitiation complex, along with translation reinitiation and rRNA processing, plus histone methylation marks. This points to a cohesive theme of gene expression regulation and ribosome assembly, with developmental terms likely representing broader roles of some proteins rather than a single pathway.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0042254","count":5},{"id":"GO:0001731","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0001843","count":4}]},{"hash":"474357974214596538","title":"Neuronal cytoskeleton remodeling and trafficking","description":"These proteins cluster around actin dynamics and trafficking: actin depolymerization, Arp2/3 regulation, and Rho GTPase signaling, plus cilium assembly and ER-Golgi vesicle transport. The presence of brain development and synaptic plasticity terms suggests a neural development/neuronal function emphasis, linking cytoskeletal remodeling to vesicular trafficking in neurons.","confidence":"Medium","size":24,"edges":117,"triangles":131,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060271","count":2},{"id":"GO:0007420","count":2}]},{"hash":"898440772613944218","title":"Unknown","description":"These GO terms span mitochondrial electron transport and Complex I assembly, microtubule/tubulin assembly, brain development, transcription elongation, protein folding, and cAMP signaling, with no single unifying function evident across the cluster; it appears to be a mixed set rather than a cohesive pathway.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032981","count":1},{"id":"GO:0051591","count":1},{"id":"GO:0048146","count":1},{"id":"GO:0019933","count":1},{"id":"GO:0007420","count":1}]},{"hash":"1859739701262828319","title":"Gene Expression and Signaling Core","description":"The top terms are dominated by translation and DNA-templated transcription, with related hints of growth and development. Additional terms indicate signaling (cAMP/cGMP) and transport (sodium import) as well as stress responses, suggesting a cluster centered on gene-expression machinery that interfaces with signaling and environmental cues.","confidence":"Medium","size":24,"edges":26,"triangles":9,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0016049","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0009636","count":2},{"id":"GO:0009454","count":2}]},{"hash":"4325237946190828","title":"Glycoprotein glycosylation in development","description":"Prominent GO terms cluster around glycosylation and glycan biosynthesis (arabinogalactan protein metabolism, hydroxyproline O-linked glycosylation, poly-N-acetyllactosamine, Lewis a epitope) and several development/cell-adhesion processes (root hair development, follicle epithelium polarity/adhesion, insect visual primordium formation). This points to a theme of cell-surface glycoproteins and glycan modifications coordinating development across species.","confidence":"Medium","size":24,"edges":73,"triangles":63,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":8},{"id":"GO:0010405","count":6},{"id":"GO:0042248","count":6},{"id":"GO:0001744","count":6},{"id":"GO:0048354","count":6}]},{"hash":"101005913059179929","title":"Embryonic development and organ morphogenesis","description":"This cluster features numerous developmental and morphogenesis terms across tissues (pancreas, placenta, mesoderm, hair follicles, cartilage, EMT in heart development, endocrine development, left-right patterning), suggesting a general embryonic development theme rather than a single pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0007498","count":2},{"id":"GO:0010957","count":2},{"id":"GO:0060707","count":2}]},{"hash":"625901663968682910","title":"MAPK signaling and cell cycle regulation","description":"These proteins cluster around MAPK-driven signaling cascades (ERK/JNK) and receptor-mediated pathways (T cell receptor, ephrin receptor), alongside DNA replication and mitotic cell cycle processes. The convergence on kinase signaling and cell-cycle control suggests a core function in MAPK-mediated signaling linked to proliferation, with some neural development annotations likely reflecting downstream effects. ","confidence":"High","size":23,"edges":31,"triangles":1,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":20},{"id":"GO:0050771","count":18},{"id":"GO:0033138","count":18},{"id":"GO:0046330","count":18},{"id":"GO:0031532","count":18}]},{"hash":"346292011515725992","title":"Dopaminergic signaling and drug response in brain","description":"This cluster is driven by neural functions and drug responsiveness: dopaminergic synaptic transmission, ERK1/ERK2 signaling, visual perception/learning, and behavioral responses to cocaine and morphine, along with brain-specific components like the brain renin-angiotensin system. The heart development term appears as a less consistent outlier, but the dominant theme points to brain signaling and reward-related pathways.","confidence":"Medium","size":23,"edges":10,"triangles":4,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":7},{"id":"GO:0019233","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0002035","count":6},{"id":"GO:0001963","count":6}]},{"hash":"1050360057231351264","title":"Broad Substrate Transmembrane Transporters","description":"The cluster is dominated by GO terms for transporting a wide range of substrates across membranes (phosphate and sodium ions, xenobiotics, vitamins, and several sugars such as fucose, galactose, arabinose, and sialic acid). This pattern points to membrane transporter proteins with broad substrate specificity. The single Wnt signaling term appears incidental and does not outweigh the transport theme, so the label reflects the core function of the cluster.","confidence":"High","size":23,"edges":31,"triangles":0,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":4},{"id":"GO:0016055","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0006004","count":3}]},{"hash":"1836163855653231835","title":"Ribosome biogenesis and translation","description":"The top terms cluster around ribosomal large subunit export from the nucleus, ribosomal large subunit assembly, maturation of LSU- and 5.8S rRNA, and translation/translation initiation. This strongly points to proteins involved in ribosome biogenesis and the core translation machinery, with LSU rRNA processing and export as key anchors.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006413","count":2}]},{"hash":"337800049641978817","title":"Embryonic Development and Neural/Visual Morphogenesis","description":"The top GO terms cluster around broad embryonic development and organ-specific morphogenesis, with strong emphasis on neural and sensory systems (cerebellum, retina, retinal ganglion/axon guidance, inner ear, visual perception) alongside general development (placenta, heart, cranial skeleton). The presence of DNA-templated transcription supports regulatory roles in developmental programs. Overall, the proteins likely participate in embryonic development with a focus on neural/visual system formation.","confidence":"High","size":23,"edges":11,"triangles":2,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0001890","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0021549","count":6},{"id":"GO:0031290","count":6}]},{"hash":"2282495588152128604","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":251,"triangles":1730,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070417","count":23},{"id":"GO:0000464","count":23},{"id":"GO:0008306","count":23},{"id":"GO:0000466","count":23},{"id":"GO:0000480","count":23}]},{"hash":"2238239376693308286","title":"Neuronal development and axon guidance","description":"The top GO terms cluster around nervous system development, including lateral motor column neuron migration, peripheral nervous system neuron axonogenesis, motor neuron axon guidance, and related cell-matrix adhesion. These together suggest a core theme of neuronal development and axon pathfinding, with some additional but less central organogenesis and signaling terms.","confidence":"High","size":23,"edges":164,"triangles":455,"max_degree":18,"top_function":"wound healing","top_go_terms":[{"id":"GO:0070527","count":12},{"id":"GO:0097477","count":12},{"id":"GO:0048936","count":11},{"id":"GO:0007160","count":11},{"id":"GO:0008045","count":11}]},{"hash":"2138717943502546769","title":"Developmental signaling and organogenesis","description":"The enriched GO terms point to embryonic tissue formation and organ development across multiple lineages (kidney nephron morphogenesis, ectoderm formation, gonad development, uterine epithelium, motor neuron differentiation) with supporting signaling pathways (integrin, NF-kappaB, growth hormone receptor). This suggests a general developmental program rather than a single tissue-specific function.","confidence":"Medium","size":23,"edges":10,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":2},{"id":"GO:2000346","count":1},{"id":"GO:0035847","count":1},{"id":"GO:0008588","count":1},{"id":"GO:0072284","count":1}]},{"hash":"1830652374800485862","title":"Synaptic signaling and mRNA regulation","description":"The cluster blends neuronal signaling terms (ephrin signaling regulation, morphine response, cAMP response) with RNA-level control (mRNA processing and stability) and cytoskeletal remodeling (actin filament bundle assembly), which together suggest proteins involved in activity-dependent synaptic function and local gene expression regulation at synapses.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":4},{"id":"GO:0007253","count":3},{"id":"GO:0006397","count":3},{"id":"GO:1901187","count":3},{"id":"GO:1900383","count":3}]},{"hash":"1060174613333820205","title":"Eye development and visual perception","description":"Dominant terms relate to visual perception and retina development (visual perception; retina vasculature development in camera-type eye), suggesting a retina/eye-focused functional theme. Supporting terms on cellular trafficking and microglia development fit into retinal development and maintenance contexts, reinforcing the eye/retina biology interpretation.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":4},{"id":"GO:0061298","count":4},{"id":"GO:0061462","count":4},{"id":"GO:0031623","count":3},{"id":"GO:0090528","count":3}]},{"hash":"207368237638387449","title":"Vesicle trafficking and ciliogenesis","description":"The cluster is enriched for GO terms related to ER-to-Golgi transport, COPII vesicle budding, microtubule-based movement, ER-associated degradation, phagolysosome assembly, and ciliogenesis, suggesting a shared function in intracellular vesicle trafficking and cilium formation; a few terms (e.g., single fertilization) are less central but don\u2019t overwhelm the core theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0001845","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0030433","count":2}]},{"hash":"419062246218920880","title":"Insect circadian sleep and neural signaling","description":"The cluster\u2019s prominent terms center on circadian/sleep regulation and neural signaling (sleep, regulation of circadian sleep/wake cycle, rhythmic process, regulation of cholinergic synaptic transmission, and voltage-gated potassium channel activity), suggesting a cohesive theme around insect neural circuits governing sleep and circadian rhythms. Other terms (glycosylation, GPI anchor biosynthesis, cuticle/tracheal regulation) appear ancillary but may relate to membrane protein processing and development in insects.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006487","count":1},{"id":"GO:0008362","count":1},{"id":"GO:1903049","count":1},{"id":"GO:0045187","count":1},{"id":"GO:0032222","count":1}]},{"hash":"1525799157862403298","title":"Metabolite and energy transporters with stress response","description":"The cluster shows enrichment for transport of various metabolites and cofactors (alpha-ketoglutarate, heme, ADP) and mRNA transport, along with stress-related processes (hypoxia response, adaptive thermogenesis, response to superoxide). This points to a group of proteins primarily involved in metabolite/energy transport and cellular stress regulation, rather than a single signaling pathway. Some cell-cycle terms appear but are less cohesive with the main theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0097274","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0008284","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0051028","count":3}]},{"hash":"1596383792906438248","title":"Unknown","description":"Top terms span metabolism, DNA damage and cell cycle processes, nuclear transport, protein degradation, inflammatory signaling, and neural/vascular development, showing no single cohesive function. This pleiotropy makes a concise label unlikely, so the cluster is Unknown with None confidence. ","confidence":"","size":22,"edges":199,"triangles":1005,"max_degree":21,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006006","count":22},{"id":"GO:0000706","count":22},{"id":"GO:0033160","count":22},{"id":"GO:0032436","count":22},{"id":"GO:1900015","count":22}]},{"hash":"255896199801247112","title":"Regulatory signaling and gene expression in development","description":"This cluster features GO terms centered on signal transduction (positive regulation of GTPase activity, kinase activity, and autophosphorylation), developmental context (brain development) and stress response (hypoxia), along with regulators of the cell cycle, actin dynamics, RNA transport, and chromatin/gene expression (histone methylation, rRNA maturation). The diverse but interconnected themes suggest a regulatory module coordinating signaling with transcriptional and translational control during development, rather than a single, narrowly defined function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0071902","count":6},{"id":"GO:0031954","count":6},{"id":"GO:0071456","count":6}]},{"hash":"101691890683578041","title":"Neuronal development and synapse regulation","description":"Most enriched GO terms relate to neuronal processes, including positive regulation of synapse assembly, dendritic spine development, and negative regulation of neuron apoptotic process, along with regulatory processes like GTPase activity and ubiquitin-protein transferase activity. This pattern points to interplay between signaling and synaptic connectivity in neurons. A few terms (acrosome assembly, floral organ abscission) are from non-neuronal contexts and likely reflect broad GO annotation across taxa, but the dominant theme fits neuronal development and synaptic regulation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0051443","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0033601","count":1}]},{"hash":"925236362564085842","title":"Wnt signaling and endocytosis in development","description":"This cluster is enriched for GO terms centered on the Wnt signaling pathway, endocytic processes (pinocytosis and endocytic recycling), and cytoskeletal regulation (Rho signaling, dendrite development). While some terms touch on cell cycle and stress response, the recurring themes map well to signaling-driven control of endocytosis and cytoskeleton during development.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048549","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0016358","count":2}]},{"hash":"827158431761997921","title":"Embryonic Organogenesis and Tissue Development","description":"This cluster is dominated by GO terms describing development and morphogenesis across multiple embryonic tissues\u2014cranial skeletal morphogenesis, primitive streak formation, placenta, heart, thyroid, inner ear, skeletal muscle, and the visual system. The recurring theme is embryonic tissue development and organ formation, with transcriptional regulation as a common regulatory layer. Therefore the label captures the shared function across the proteins.","confidence":"High","size":22,"edges":22,"triangles":2,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048701","count":10},{"id":"GO:0000122","count":10},{"id":"GO:0090009","count":10},{"id":"GO:0048935","count":9},{"id":"GO:0001890","count":8}]},{"hash":"1071198089487446902","title":"B cell signaling and actin cytoskeleton remodeling","description":"Top GO terms indicate a theme of B cell receptor signaling and Fc receptor\u2013mediated pathways, intertwined with regulation of Rho signaling and actin dynamics (ruffle assembly, barbed-end capping, membrane invagination). This combination points to proteins that coordinate receptor-triggered signaling with cytoskeletal remodeling to enable immune cell activation and endocytosis. Although some terms reflect broader developmental processes, the dominant pattern is immune signaling linked to actin-driven membrane remodeling.","confidence":"High","size":22,"edges":13,"triangles":0,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0051016","count":3},{"id":"GO:0010863","count":3},{"id":"GO:1900029","count":3}]},{"hash":"950316492731197800","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006486","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0033623","count":2},{"id":"GO:0046847","count":2}]},{"hash":"689638351884582722","title":"Glycan biosynthesis and sugar-nucleotide metabolism","description":"Top terms indicate glycogen and trehalose biosynthesis along with multiple UDP-sugar pathways (UDP-L-arabinose, UDP-D-galactose, UDP-glucuronate) and glucan biosynthesis, collectively pointing to glycan assembly and cell wall/storage polysaccharide production. A few terms related to development appear incidental and do not disrupt the overall glycan-centric theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":2},{"id":"GO:0005992","count":2},{"id":"GO:0060716","count":2},{"id":"GO:0009949","count":2},{"id":"GO:0006035","count":1}]},{"hash":"1418180767051300466","title":"Neural development and visual synaptic function","description":"Based on the strong representation of neural-related terms (axonogenesis, long-term potentiation, excitatory postsynaptic potential, visual perception) and related signaling (mRNA transport, GTPase regulation), this cluster appears to group proteins involved in neural development and synaptic signaling, with a leaning toward vision-related processing. Some cell-cycle terms are present, but they are less central to the dominant neural theme.","confidence":"High","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":13},{"id":"GO:0008284","count":12},{"id":"GO:0071456","count":12},{"id":"GO:0051028","count":12},{"id":"GO:0043065","count":11}]},{"hash":"27067382080503356","title":"Wnt and Hippo signaling in development and differentiation","description":"Multiple top GO terms cluster around signaling pathways that regulate growth and fate, notably canonical Wnt signaling and Hippo pathway, along with transcriptional control and differentiation of keratinocytes. This suggests proteins in the group coordinate development, cell cycle decisions, apoptosis, and tissue differentiation. A few terms (visual perception, chemotaxis) seem less consistent with these themes, potentially reflecting broader annotations or cross-tissue roles.","confidence":"High","size":21,"edges":208,"triangles":1292,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0046827","count":8},{"id":"GO:0090263","count":7},{"id":"GO:0006915","count":7}]},{"hash":"1765561032452508714","title":"RNA processing and cell cycle regulation","description":"These proteins show enrichment for RNA processing and splicing (regulatory ncRNA-mediated gene silencing; positive regulation and alternative splicing via spliceosome), chromatin remodeling, and cell-cycle\u2013related processes (mitotic cell cycle, regulation of cell cycle, transcriptional regulation), suggesting a coordinated module governing gene expression and cell-cycle control.","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0000380","count":3},{"id":"GO:0043044","count":2},{"id":"GO:0042273","count":2}]},{"hash":"107308116880454432","title":"RNA processing and translation control","description":"This cluster centers on post-transcriptional regulation of gene expression. Top GO terms cover ncRNA-mediated silencing, mRNA splicing and stability, translation initiation/reinitiation, and IRES-dependent translation, indicating coordinated RNA processing and control of translation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":10},{"id":"GO:0010610","count":10},{"id":"GO:0048026","count":9},{"id":"GO:0045292","count":8},{"id":"GO:0002188","count":8}]},{"hash":"1207817781758787883","title":"Broad Negative Regulators of Cell Signaling","description":"The top GO terms point to inhibition across several signaling pathways (ERK cascade, T cell receptor signaling, PI3K/AKT), plus tyrosine dephosphorylation and suppression of focal adhesion, cell cycle kinase activity, and apoptotic signaling. This pattern suggests a cluster of proteins that primarily act as negative regulators of signaling and related cellular processes, with occasional links to mitosis (kinetochore localization) and vesicle dynamics.","confidence":"High","size":21,"edges":191,"triangles":1025,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":14},{"id":"GO:0070373","count":14},{"id":"GO:0050860","count":14},{"id":"GO:0035335","count":11},{"id":"GO:0051895","count":10}]},{"hash":"106543645150209982","title":"Actin Remodeling and Cell Migration","description":"Several top GO terms point to actin cytoskeleton dynamics and cell movement (e.g., positive regulation of Arp2/3-mediated actin nucleation, microtubule-based movement, and cell migration). These suggest the proteins in this cluster participate in actin remodeling and motility. Additional terms about spindle orientation, translation initiation, and hypoxia response appear as broader connections, but the dominant theme is cytoskeletal reorganization driving movement.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0016477","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0007018","count":4},{"id":"GO:0000132","count":4}]},{"hash":"659806558385662541","title":"Embryonic and Organogenesis Development","description":"GO terms span pancreas development, placental differentiation, cartilage morphogenesis, retinal and inner ear development, left-right patterning, EMT in cardiovascular/heart cushion formation, and endocrine system development, all pointing to embryonic organogenesis across tissues.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0003198","count":3}]},{"hash":"215221061616312030","title":"Mitochondrial energy metabolism and translation","description":"This cluster centers on mitochondrial energy production (TCA cycle and proton motive force-driven ATP synthesis) and mitochondrial calcium homeostasis, with supporting translation and ribosome assembly terms, indicating a link between mitochondrial metabolism and protein synthesis machinery.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0099132","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0015986","count":2},{"id":"GO:0051560","count":2}]},{"hash":"1304717254640026046","title":"Sensory, skeletal, and neural development","description":"The dominant GO terms point to developmental processes across multiple systems\u2014lens fiber differentiation, bone/skeletal development, otolith morphogenesis, axonal fasciculation, and myelination\u2014reflecting vertebrate organogenesis and nervous-system development. The diversity prevents a single precise function, but the common theme is embryonic tissue development rather than a specific molecular pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0051965","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0045087","count":2}]},{"hash":"249557702586948452","title":"Regulators of Signaling and Phosphorylation","description":"Based on GO terms such as regulation of root meristem growth, activation of adenylate cyclase, calcium release, protein phosphorylation, cAMP signaling, opsin-mediated signaling, GTPase activity, and regulation of muscle contraction, the shared theme is proteins that modulate signaling pathways and phosphorylation rather than executing a single downstream action. The cluster thus reflects regulators of multiple signal transduction processes (calcium, cAMP, GTPases) across diverse systems.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010082","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0006468","count":2},{"id":"GO:0043950","count":2}]},{"hash":"707304548004952172","title":"Neural development and T cell signaling","description":"It combines neural development terms (negative regulation of axonogenesis, hippocampus development) with T cell signaling terms (T cell receptor signaling, beta selection) and related pathways (MAPK cascades, ephrin receptor signaling), suggesting a theme of developmentally regulated signaling across neural and immune contexts.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":15},{"id":"GO:0033138","count":15},{"id":"GO:0046330","count":15},{"id":"GO:0031532","count":15},{"id":"GO:0000278","count":15}]},{"hash":"1246893161903809286","title":"Spliceosome-Driven RNA Processing and Translation Regulation","description":"Based on the prominent GO terms, the cluster centers on RNA processing and splicing via the spliceosome, including regulation of alternative splicing and mRNA stability under stress, with adjacent signals for translation initiation and reinitiation. This suggests a coherent theme of post-transcriptional gene expression control, where spliceosome-mediated RNA processing is linked to regulation of translation.","confidence":"High","size":20,"edges":182,"triangles":1011,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":16},{"id":"GO:0045292","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0002188","count":11},{"id":"GO:0006378","count":11}]},{"hash":"717540861579229525","title":"Embryonic Organ Morphogenesis","description":"Top GO terms indicate broad embryonic tissue development and morphogenesis across multiple organs (eye, habenula, heart/outflow tract, hindlimb, placenta, gonads, prostate). The convergence on organogenesis and tissue patterning suggests these proteins participate in general developmental programs rather than a single tissue process, with some involvement in transcriptional regulation during development. This supports a label of embryonic morphogenesis as a representative theme.","confidence":"High","size":20,"edges":88,"triangles":121,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":11},{"id":"GO:0021986","count":9},{"id":"GO:2000288","count":9},{"id":"GO:0003148","count":8},{"id":"GO:0001890","count":8}]},{"hash":"567487135057853246","title":"Mitochondrial dynamics and innate immunity","description":"Based on the dominant GO terms, the cluster centers on mitochondrial processes (fission, membrane organization) and cellular stress responses (apoptosis, cell cycle), with intrinsic antiviral/immune signaling (response to interferon-alpha, negative regulation of viral genome replication). Translation and vacuole targeting appear as additional processes, and a singular GABAergic synaptic term may reflect cross-functional roles. Overall, a mitochondria-driven stress and antiviral signaling theme best captures the cluster.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0007605","count":4},{"id":"GO:0000266","count":3},{"id":"GO:0035455","count":3},{"id":"GO:0045071","count":3}]},{"hash":"1697941307965802093","title":"Developmental Regulation and Actin Dynamics","description":"The cluster features strong signals for multicellular development (e.g., neural tube closure, male gonad development) and cytoskeletal control (positive regulation of GTPase activity, barbed-end actin filament capping), suggesting roles in developmental processes that involve actin remodeling. Some terms about rRNA maturation and histone methylation are present but appear less coherent with the core theme, indicating a moderately supported but not exclusively cohesive set of functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0045671","count":2}]},{"hash":"1654754872970067260","title":"Unknown","description":"These GO terms span oxidation-reduction, lipopolysaccharide biosynthesis, pigmentation, antibiotic response, B cell chemotaxis, poly-hydroxybutyrate biosynthesis, somitogenesis regulation, cell adhesion, lung development, and hypoxia response, with no clear single function tying the proteins together. The diversity indicates no coherent shared role, so a concise representative label cannot be confidently assigned.","confidence":"","size":20,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0009103","count":3},{"id":"GO:0043473","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0035754","count":3}]},{"hash":"2174186799498241504","title":"GPCR Signaling and Synaptic Plasticity","description":"These proteins show a pattern centered on G protein-coupled receptor signaling in neural contexts (acetylcholine receptor pathway, bitter taste GPCRs), with downstream IP3 biosynthesis, involvement in glutamate receptor signaling, and long-term potentiation, pointing to roles in synaptic transmission and plasticity rather than general metabolism.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050913","count":2},{"id":"GO:0009395","count":2},{"id":"GO:0007213","count":2},{"id":"GO:0032959","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1539230859118359440","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0046784","count":3},{"id":"GO:0030593","count":2},{"id":"GO:0051016","count":2},{"id":"GO:2001162","count":2}]},{"hash":"1300803143248128945","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":171,"triangles":855,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0006367","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0042797","count":3},{"id":"GO:0001172","count":3}]},{"hash":"393538530104343919","title":"B cell maturation and immunoglobulin diversification","description":"The cluster is dominated by isotype switching and somatic hypermutation terms, along with DNA replication, pointing to germinal center\u2013related B cell maturation and antibody gene diversification. Supporting signaling terms (adenylate cyclase activation, cAMP regulation, GTPase activity, protein phosphorylation) reflect common lymphocyte signaling processes. A few terms related to vision/opsin pathways appear as outliers, but the central theme remains B cell antibody diversification and signaling.","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045190","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0016446","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0006468","count":2}]},{"hash":"1588348171939872512","title":"Vertebrate organogenesis and neural differentiation","description":"The top GO terms show a mix of neural development (amacrine interneuron differentiation, GABAergic interneuron differentiation, spinal cord neuron fate), neural tube patterning (floor plate development, somitogenesis), and several organogenesis processes (lung vasculature, bronchiole development, endocrine pancreas development), indicating a broad embryonic development program with a strong neural differentiation component.","confidence":"High","size":20,"edges":187,"triangles":1089,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0033504","count":9},{"id":"GO:0001756","count":9},{"id":"GO:0060426","count":9},{"id":"GO:0035881","count":9}]},{"hash":"2171596432336375879","title":"T cell and tissue homeostasis","description":"The cluster is enriched for immune- and tissue-regulation terms, notably T cell homeostasis and T cell apoptotic process, along with broader tissue-level cell-number homeostasis. Despite some obsolete terms, the common thread is regulation of cell survival, numbers, and organization within tissues, with a notable emphasis on T cells. This supports labeling the cluster as focused on immune and tissue homeostasis, though the presence of reproductive-related terms adds some diversity. ","confidence":"Medium","size":20,"edges":21,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0060058","count":2},{"id":"GO:0048147","count":2},{"id":"GO:0048515","count":2}]},{"hash":"1750645527697186787","title":"ER-Golgi to Vacuole Trafficking and Autophagy","description":"The cluster is dominated by GO terms for ER-to-Golgi vesicle transport, Golgi-to-vacuole transport, COPII vesicle coating regulation, and macroautophagy, indicating a cohesive role in secretory and vacuolar trafficking with autophagy as a related pathway; auxiliary terms on protein targeting to vacuole, apoptosis, and antigen processing via MHC II fit within these trafficking and autophagy-related processes as context-specific connections.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0006623","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0006896","count":3},{"id":"GO:0016236","count":2}]},{"hash":"1538808428746567758","title":"Ubiquitin-Proteasome System and Stress Signaling","description":"This cluster is strongly enriched for ubiquitin-dependent protein catabolic processes, including SCF-dependent degradation, polyubiquitination, and autoubiquitination, indicating core components of the ubiquitin-proteasome system. Additional GO terms reflect related stress and signaling connections (cadmium/methylmercury response, circadian rhythm regulation, TNF signaling, and oxidative-stress\u2013related apoptosis), suggesting a module where ubiquitination governs protein turnover and links to stress and rhythm pathways. Confidence: High","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0031146","count":7},{"id":"GO:0051865","count":6},{"id":"GO:1903378","count":6},{"id":"GO:1903265","count":6}]},{"hash":"537125060524021424","title":"Ubiquitin-Proteasome-Mediated Degradation","description":"The cluster\u2019s GO terms cluster around proteasome function, ubiquitin-dependent protein catabolism, and deubiquitination/deneddylation, signaling a shared involvement in protein turnover and regulation by the ubiquitin-proteasome system; other terms like mitochondrial fission or cell cycle regulation may reflect broader cellular coordination but do not redefine the core theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902906","count":1},{"id":"GO:0000266","count":1},{"id":"GO:0035522","count":1},{"id":"GO:0043161","count":1},{"id":"GO:0034286","count":1}]},{"hash":"1953483660683144615","title":"Neuronal development and MAPK pathway regulation","description":"This cluster\u2019s top GO terms cluster around nervous system development, neurogenesis, and regulation of MAPK signaling (ERK1/2 and JNK cascades), with supporting terms like apoptotic process and transcriptional control, pointing to proteins involved in neural development and signaling modulation. The presence of these specific, development-related terms supports a focused theme rather than a generic set.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043552","count":3},{"id":"GO:0046330","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0022008","count":3}]},{"hash":"1650140964192435067","title":"Spliceosome-Driven mRNA Processing","description":"Dominant terms center on spliceosome-mediated splicing (cis and alternative) and other post-transcriptional RNA maturation steps, including mRNA export and translation reinitiation, with additional signals from ncRNA-mediated gene silencing and processome-associated RNA processing. This suggests a cohesive module focused on RNA splicing and mRNA maturation.","confidence":"High","size":19,"edges":143,"triangles":665,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":16},{"id":"GO:0048026","count":16},{"id":"GO:0045292","count":10},{"id":"GO:0006378","count":10},{"id":"GO:0010610","count":10}]},{"hash":"593436935532898589","title":"Tissue Development and Differentiation","description":"This cluster shows a broad set of development- and differentiation-related GO terms across many tissues (pancreas, muscle, liver/hepatocytes, heart, nerves, oligodendrocytes, mast cells, and noradrenergic neurons) with RNA polymerase II\u2013mediated transcription as a central process, suggesting a group of proteins involved in general and lineage-specific differentiation programs rather than a single tissue function.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0031018","count":13},{"id":"GO:0035914","count":13},{"id":"GO:0070368","count":12},{"id":"GO:0060411","count":12}]},{"hash":"1617241825828821773","title":"Embryonic development and tissue differentiation","description":"Top GO terms indicate neural development (neural tube closure, forebrain development), skeletogenesis and bone differentiation (osteoblast differentiation, skeletal system morphogenesis), and lens fiber differentiation, plus single fertilization. This suggests a cluster enriched for embryonic organogenesis and tissue differentiation across neural, skeletal, and ocular lineages. The translation-related terms are ancillary; overall the dominant signal is developmental differentiation, supporting the proposed label with moderate confidence.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":6},{"id":"GO:0002188","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0007338","count":4},{"id":"GO:0048705","count":4}]},{"hash":"478568386068952883","title":"Ubiquitin-Dependent Protein Turnover and Cell Cycle","description":"Based on the top GO terms, the cluster is dominated by ubiquitination-related processes (polyubiquitination, ubiquitin-dependent protein catabolic process, protein ubiquitination) and cell cycle/cell division, suggesting a cohesive theme of ubiquitin-mediated protein turnover that regulates cell cycle progression. Secondary terms such as responses to cadmium, NOD2 signaling, and vitamin D likely reflect ancillary roles or broader regulatory contexts, but do not override the core ubiquitin association.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000209","count":5},{"id":"GO:0071276","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042787","count":4}]},{"hash":"2267688647317664702","title":"Rho/Rac GTPase signaling and membrane trafficking","description":"The GO terms point to regulation of GTPase activity, specifically Rho and Rac pathways, plus membrane-related processes such as plasma membrane tubulation and endosome-to-lysosome transport. This pattern suggests a function in coordinating cytoskeletal remodeling with vesicle trafficking, rather than a single enzymatic role. Some other terms (developmental and cell cycle) may reflect broader cellular contexts for these pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007584","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0000747","count":2},{"id":"GO:0021510","count":2}]},{"hash":"1697221845556395686","title":"Unknown","description":"The top GO terms span cGMP signaling, sensory processes (smell and cone development), immune responses (lipopolysaccharide response, neutrophil homeostasis), and cardiac muscle regulation. There is no single dominant biological function tying these together, making it unclear to assign a cohesive label.","confidence":"","size":19,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071321","count":6},{"id":"GO:0010754","count":6},{"id":"GO:0007608","count":6},{"id":"GO:0071222","count":5},{"id":"GO:0046827","count":4}]},{"hash":"1354097826765788482","title":"Mitotic Regulation and Nuclear Export","description":"The dominant GO terms point to mitosis (G2/M transition, centrosome duplication, kinetochore localization) and to nuclear export (mRNA, pre-miRNA, protein export), suggesting a cluster of proteins involved in cell-cycle control with coordinated transport.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042176","count":3},{"id":"GO:0034501","count":3},{"id":"GO:0045719","count":2},{"id":"GO:0006935","count":2},{"id":"GO:0000086","count":2}]},{"hash":"1128465380239926643","title":"Epigenetic Regulation and Transcription Control","description":"The top GO terms center on transcriptional repression/regulation via chromatin modifiers (histone H3-K27 methylation) and DNA methylation, plus RNA polymerase II regulation, indicating a cohesive epigenetic regulation cluster; a few terms touch on neural development and sensory-related processes, but the core theme is epigenetic control of gene expression.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061086","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0090630","count":3},{"id":"GO:0060292","count":2},{"id":"GO:0010216","count":2}]},{"hash":"1833399823216572495","title":"Ciliogenesis and Photoreceptor Development","description":"The Top Terms point to cilia assembly and developmental processes (embryonic digit and skeletal morphogenesis) along with retinal cone cell development and signaling via adenylate/guanylate cyclases. This combination suggests a theme centered on ciliary biogenesis and cyclic nucleotide signaling that influences development and photoreceptor lineage, rather than a single, narrow pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0042733","count":2},{"id":"GO:0048706","count":2},{"id":"GO:0044458","count":2}]},{"hash":"244515517281472789","title":"ER stress response and protein folding","description":"These proteins cluster around endoplasmic reticulum\u2013related quality control: multiple GO terms point to protein folding in the ER, response to unfolded protein, and translation initiation changes under ER stress, accompanied by redox homeostasis. The presence of terms like negative regulation of inclusion body assembly and post-translational targeting to membrane further supports ER-associated chaperone activity and trafficking. A few items (e.g., DNA replication) may be ancillary, but the dominant signal is ER stress\u2013driven protein folding and quality control.","confidence":"High","size":18,"edges":46,"triangles":51,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045454","count":10},{"id":"GO:0034975","count":9},{"id":"GO:0006986","count":7},{"id":"GO:0070389","count":7},{"id":"GO:0090084","count":6}]},{"hash":"930190863634263223","title":"Lung branching morphogenesis and ECM remodeling","description":"The top GO terms overwhelmingly point to lung development and branching (epithelial tube branching involved in lung morphogenesis; dichotomous subdivision of terminal units involved in lung branching) and to ECM remodeling via collagen catabolic processes, suggesting a cluster centered on lung morphogenesis with accompanying tissue remodeling. Other terms present (bradykinin catabolic process, thyroid hormone response, decidualization, T cell\u2013mediated cytotoxicity, neural precursor proliferation) are more peripheral and do not define the main theme, which is developmental branching in the lung with ECM remodeling.","confidence":"High","size":18,"edges":125,"triangles":462,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":6},{"id":"GO:0030574","count":6},{"id":"GO:2000179","count":6},{"id":"GO:0010815","count":6},{"id":"GO:0001913","count":6}]},{"hash":"29040710976107998","title":"Neural differentiation transcription factors","description":"This cluster is strongly enriched for transcriptional regulation by RNA polymerase II and for neural lineage differentiation, including cerebral cortex GABAergic interneuron differentiation and spinal cord motor neuron cell fate specification, suggesting a set of transcriptional regulators guiding neural development. Broader developmental terms (e.g., bronchiole and endocrine pancreas development) are present but seem secondary to the neural differentiation signal.","confidence":"High","size":18,"edges":149,"triangles":754,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0031018","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0071353","count":5}]},{"hash":"1455019370189060544","title":"Ubiquitin-mediated antiviral innate immunity","description":"The top GO terms cluster around innate antiviral defense and ubiquitin processes (defense response to virus, innate immune response, protein ubiquitination, and autoubiquitination), indicating a module where ubiquitin signaling modulates antiviral immunity and related apoptosis regulation. Placenta morphogenesis appears as noise relative to the dominant immune/ubiquitin signals.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060669","count":4},{"id":"GO:0016567","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0045087","count":3},{"id":"GO:1903762","count":3}]},{"hash":"1944288053728440313","title":"Neural development, ciliogenesis, and cytoskeletal signaling","description":"Top GO terms cover neural development (neurogenesis, presynaptic vesicle exocytosis), ciliary assembly (intraciliary transport for cilium assembly), and cytoskeletal regulation (regulation of Rho signaling), plus developmental processes like myoblast fusion and spermatid nucleus elongation. Ribophagy and apoptosis indicate cellular remodeling and turnover. The collection spans developmental programs across neural, muscular, and reproductive contexts with a tilt toward cilia and cytoskeletal pathways, rather than a single specific function, hence this label.","confidence":"Medium","size":18,"edges":33,"triangles":6,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":4},{"id":"GO:0007290","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0034517","count":3}]},{"hash":"1606362325300156568","title":"Brain and Neural Development","description":"Top terms cluster around neural and brain-related processes (brain development, midbrain development, inner ear development, locomotory behavior, synapse assembly). While a few terms touch on proteolysis or transcriptional regulation and one is immune-related, the dominant theme is neural development and connectivity, supporting this label.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0048839","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0007275","count":3}]},{"hash":"863931156378144585","title":"DNA replication and cell cycle regulation","description":"This cluster is dominated by GO terms tied to genome maintenance and cell division\u2014DNA replication, mitotic cell cycle, DNA-templated transcription, and DNA repair\u2014suggesting a group of proteins involved in genome duplication and cell-cycle control. Additional terms point to proteostasis and signaling, but the core theme remains nuclear DNA processing and cell cycle progression.","confidence":"High","size":18,"edges":51,"triangles":33,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":17},{"id":"GO:0000278","count":16},{"id":"GO:0006351","count":16},{"id":"GO:0006281","count":16},{"id":"GO:0051893","count":16}]},{"hash":"403086195529622342","title":"Developmental and Immune Signaling","description":"The cluster is enriched for multiple signaling pathways tied to development (Roundabout/ROBO signaling, Smoothened/Hedgehog, kidney and nervous system development, bone ossification) as well as immune signaling (T cell receptor signaling, mast cell chemotaxis) and common intracellular cascades (ERK/PI3K). This pattern points to a cohesive theme of signal transduction governing development and immune cell functions, rather than a single, narrow process.","confidence":"Medium","size":18,"edges":102,"triangles":244,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":6},{"id":"GO:0001822","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0043931","count":5}]},{"hash":"1686166130030986647","title":"Nucleotide salvage and gene expression","description":"This cluster is enriched for DNA-templated transcription, translation, and transcription termination, alongside nucleotide salvage and biosynthesis (guanine/GMP/uracil salvage and PRPP biosynthesis). Together these terms point to a cohesive theme around nucleic acid metabolism and the gene-expression machinery. Some tissue-specific terms (striatum development, lactation) appear but are likely incidental to the core functions.","confidence":"High","size":18,"edges":28,"triangles":5,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007595","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006353","count":2},{"id":"GO:0021756","count":2}]},{"hash":"2055859540395830293","title":"GPCR Signaling in Development and Immunity","description":"The top GO terms point to G protein-coupled receptor signaling (including phospholipase C-activating pathways and dopamine receptor signaling) with downstream calcium signaling, alongside diverse developmental processes (nipple morphogenesis, kidney glomerulus development, lung connective tissue development) and immune/inflammatory responses (inflammatory response, neutrophil chemotaxis), plus a visual perception term that can be linked to GPCR-mediated sensory pathways. This suggests a cluster of proteins involved in GPCR-driven signaling that intersects development, vision, and immunity rather than a single narrow function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060658","count":2},{"id":"GO:0072224","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0006954","count":2}]},{"hash":"1088337740549854532","title":"Calcium signaling in sensory and cardiovascular processes","description":"The cluster centers on calcium ion release and cytosolic calcium regulation (e.g., release of sequestered Ca2+), with supporting terms spanning sensory perception, phototransduction, thermogenesis, coagulation, heart rate regulation, and neutrophil chemotaxis. This suggests a unifying theme of calcium-dependent signaling impacting sensory, metabolic, cardiovascular, and immune functions, making the label representative of the cluster\u2019s core function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051281","count":6},{"id":"GO:0051209","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0007596","count":6}]},{"hash":"842341060971556364","title":"NF-kB-driven inflammatory signaling","description":"This cluster is dominated by GO terms tied to NF-kB pathway activation and TNF-mediated signaling, plus a note on monocyte differentiation, pointing to an immune/inflammatory signaling theme and transcriptional regulation via NF-kB. Some terms about RNA processing and cell-cycle-related processes are present but do not define the core function; the inflammatory signaling pattern is the strongest signal.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045657","count":2},{"id":"GO:0051092","count":2},{"id":"GO:1903721","count":2},{"id":"GO:0000288","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1236456584972738141","title":"Brain development and neuroendocrine signaling","description":"This cluster's terms point to brain-related development and function: cerebellum development, proprioception, and maternal behavior suggest neural circuits and behavior, while catecholamine secretion and glucocorticoid metabolism reflect neuroendocrine signaling. Some terms are obsolete histone modification entries, which may be annotation noise, but the core theme appears to be neural development and brain hormone regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044026","count":1},{"id":"GO:0050432","count":1},{"id":"GO:0007585","count":1},{"id":"GO:0008211","count":1},{"id":"GO:0051151","count":1}]},{"hash":"210653925997817759","title":"Developmental cytoskeleton remodeling and signaling","description":"The Top Terms reveal actin dynamics (barbed-end capping, ruffle assembly, membrane invagination) and regulatory signaling (positive regulation of canonical Wnt signaling, GTPase activity). Development-related processes (heart development, branching in mammary gland morphogenesis, mast cell proliferation) imply morphogenetic roles that depend on cytoskeleton remodeling and signal transduction. Overall, the cluster seems to group proteins coordinating actin remodeling with developmental signaling and morphogenesis.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051016","count":2},{"id":"GO:0010863","count":2}]},{"hash":"1276983762740950059","title":"Embryonic axis specification and organogenesis","description":"These terms point to embryogenesis with axis specification and organogenesis, including endoderm development, foregut morphogenesis, and somite/axis patterning, along with transcriptional regulation (DNA-templated and snRNA transcription). A few terms (viral process, SMAD phosphorylation) are peripheral, but the dominant theme is embryonic development and body plan patterning.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007492","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007352","count":3},{"id":"GO:0048617","count":3}]},{"hash":"429708970322536302","title":"COPII Trafficking and Ubiquitin-Proteasome Turnover","description":"The top GO terms cluster around COPII vesicle budding and ubiquitin-dependent proteolysis, pointing to ER-to-Golgi trafficking and protein quality control as the core theme, with other terms likely reflecting broader remodeling processes.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":2},{"id":"GO:0048822","count":1},{"id":"GO:0045721","count":1},{"id":"GO:0033033","count":1},{"id":"GO:0043161","count":1}]},{"hash":"1237643260015522499","title":"Unknown","description":"The terms span several unrelated processes (secretory pathway, ER protein folding, autophagy, lipid biosynthesis, various signaling pathways, and physiological/regulatory terms) with no clear, single theme tying them together. Because there isn\u2019t a cohesive function that predominates, a concise, representative label cannot be assigned. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009306","count":1},{"id":"GO:0034975","count":1},{"id":"GO:0000045","count":1},{"id":"GO:0006656","count":1},{"id":"GO:0051482","count":1}]},{"hash":"1137715064405659165","title":"Unknown","description":"The proteins contribute to diverse biological processes, including neurotransmitter secretion, GPCR signaling, cell cycle, cytoskeletal transport, organ development (bone, retina), myofibril assembly, apoptosis, and transcription factor regulation. Because there isn't a single shared function or pathway that ties these terms together, there isn't a concise, representative label that captures the cluster's core biology.","confidence":"","size":17,"edges":82,"triangles":212,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007269","count":9},{"id":"GO:0007205","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0031284","count":8},{"id":"GO:0055003","count":8}]},{"hash":"2237448882548019213","title":"Cardiac hypertrophy signaling and myofibril assembly","description":"The top GO terms cluster around heart-specific signaling and structural growth: positive regulation of calcineurin-NFAT signaling, guanylate and adenylate cyclase activities, and positive regulation of cardiac muscle hypertrophy, along with cardiac myofibril assembly. This suggests a module of proteins involved in cardiac signaling and contractile apparatus development under stress. Some outlier terms (retinal development, nurse cell transport) may be annotation noise but do not define the core theme.","confidence":"High","size":17,"edges":36,"triangles":26,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":8},{"id":"GO:1903244","count":8},{"id":"GO:0051533","count":7},{"id":"GO:0031284","count":6},{"id":"GO:0055003","count":6}]},{"hash":"636038957688854200","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000350","count":1},{"id":"GO:0000389","count":1},{"id":"GO:0000380","count":1},{"id":"GO:0000466","count":1},{"id":"GO:0000463","count":1}]},{"hash":"2252312856449863997","title":"Ribosome biogenesis and translation initiation","description":"This cluster is dominated by GO terms related to ribosome assembly and translation initiation, including ribosome biogenesis (GO:0042254), maturation of 5.8S rRNA (GO:0000466), translation reinitiation (GO:0002188), and formation of the translation preinitiation complex (GO:0001731), indicating a cohesive theme around building ribosomes and starting protein synthesis. Some terms about methylation and protein interactions appear but do not override the central ribosome/translation focus.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002188","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0030433","count":6},{"id":"GO:0070208","count":6},{"id":"GO:0051260","count":6}]},{"hash":"280178382053141695","title":"Dopaminergic neuronal metabolism and signaling","description":"This cluster combines terms for energy metabolism (TCA cycle, glutamate catabolic), calcium-mediated signaling, vesicular loading of aminergic neurotransmitters, and dopamine biosynthesis, pointing to functions in dopaminergic neuron energy supply and neurotransmission, with additional alkaloid response terms reflecting neural stress/detox pathways.","confidence":"High","size":17,"edges":103,"triangles":313,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0019722","count":3},{"id":"GO:0046684","count":3},{"id":"GO:0033076","count":3},{"id":"GO:0071312","count":3}]},{"hash":"751859073704221952","title":"Inner ear hair cell development and glutamatergic synapses","description":"The top GO terms point to inner ear development, stereocilium organization in receptor cells, and glutamatergic synaptic transmission, all of which are characteristic of inner ear hair cell formation and their synapses with auditory neurons, along with supporting notes on neural and planar polarity-related cytoskeletal organization. This suggests a cohesive theme of sensory cell development and synaptic signaling in the inner ear.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0007626","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0051965","count":5}]},{"hash":"2261671552720164653","title":"Cell signaling and trafficking","description":"The proteins show relationships to multiple signaling pathways (TGFB receptor signaling; intracellular signal transduction; TLR4 signaling) as well as membrane trafficking and ubiquitin-dependent sorting (membrane invagination; protein transport to vacuole via MVB pathway). There are also neural/behavioral associations (excitatory postsynaptic potential; startle and suckling behaviors), suggesting a broad theme of cellular communication and membrane trafficking across systems rather than a single, cohesive pathway. Thus, a general label of cell signaling and trafficking best captures the shared functional context.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007179","count":3},{"id":"GO:0060079","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0001964","count":2},{"id":"GO:0001967","count":2}]},{"hash":"301315278152065884","title":"DNA replication and cell cycle regulation","description":"The top GO terms are dominated by nuclear processes: DNA replication (GO:0006260), centrosome cycle (GO:0007098), positive regulation of nuclear cell cycle DNA replication (GO:0010571), and DNA-templated transcription (GO:0006351), indicating core activities governing DNA duplication and cell division. Additional terms touch on development and multicellular organism processes, and immune signaling (lipopolysaccharide response, T cell receptor signaling), which may reflect context-specific regulation rather than a primary function of the cluster. Overall, the strongest signal is around DNA replication and cell-cycle control, so the label DNA replication and cell cycle regulation captures the main theme.","confidence":"High","size":17,"edges":11,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":11},{"id":"GO:0048701","count":11},{"id":"GO:0007098","count":11},{"id":"GO:0010571","count":11},{"id":"GO:0006351","count":11}]},{"hash":"950097371801418683","title":"Neural development and axon guidance","description":"The cluster\u2019s top GO terms cluster around nervous system development, axon guidance, Hedgehog/Smoothened signaling, and collateral sprouting, indicating a neural development and connectivity theme. While a few terms touch on bone ossification and mast cell chemotaxis, the dominant signals point to neural differentiation and wiring. This supports labeling the group as neural development and axon guidance, with some peripheral developmental signals contributing context.","confidence":"Medium","size":17,"edges":19,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055091","count":2},{"id":"GO:0097345","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0002551","count":2},{"id":"GO:0043552","count":2}]},{"hash":"228328337949339862","title":"Muscle fiber formation and actin dynamics","description":"The cluster is dominated by terms for skeletal muscle fiber development and sarcomere organization, and includes Arp2/3 complex\u2013mediated actin nucleation, indicating strong emphasis on actin cytoskeleton remodeling relevant to muscle structure. Some terms touch neural tissues (substantia nigra development, retina homeostasis), but the strongest pattern points to muscle development and cytoskeletal organization.","confidence":"Medium","size":17,"edges":110,"triangles":359,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048741","count":7},{"id":"GO:0021762","count":7},{"id":"GO:0043982","count":4},{"id":"GO:0016344","count":4},{"id":"GO:0034314","count":4}]},{"hash":"1348546752511811352","title":"DNA Replication and Repair Machinery","description":"The enriched GO terms cluster around genome maintenance: DNA replication, DNA recombination, and repair (e.g., GO:0006260, GO:0006310, GO:1990918), including removal of RNA primers in mitotic replication and maintenance of trinucleotide repeats. While a few metabolic biosynthesis terms appear, they are less central to this cluster\u2019s theme, which is best described as DNA replication and repair machinery.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006310","count":2},{"id":"GO:1903469","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0016311","count":2}]},{"hash":"156286584784028962","title":"Spliceosome-Mediated mRNA Processing and Export","description":"The top GO terms cluster around mRNA splicing via the spliceosome, regulation of alternative splicing, mRNA stability under stress, and mRNA export, with related RNA-processing steps like small-subunit processome assembly and translation reinitiation, indicating a group of proteins involved in post-transcriptional RNA processing and export.","confidence":"High","size":17,"edges":57,"triangles":61,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":13},{"id":"GO:0010610","count":12},{"id":"GO:0045292","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0048026","count":11}]},{"hash":"569585705737075593","title":"Golgi-Mediated Synaptic Receptor Trafficking","description":"The cluster centers on Golgi apparatus\u2013related trafficking and synaptic receptor delivery: Golgi ribbon formation, ER-to-Golgi and intra-Golgi transport, SNARE complex assembly, vesicle fusion with Golgi, and exocytic insertion of neurotransmitter receptors to the postsynaptic membrane, tied to long-term potentiation. This points to a cohesive role in delivering receptors to the synapse through Golgi-dependent vesicle trafficking.","confidence":"High","size":17,"edges":23,"triangles":15,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":9},{"id":"GO:0060291","count":9},{"id":"GO:0098967","count":9},{"id":"GO:0006888","count":9},{"id":"GO:0006891","count":9}]},{"hash":"99502675926719244","title":"Muscle and Synapse Cytoskeleton Dynamics","description":"The set centers on cytoskeletal remodeling and organization (Arp2/3 nucleation, sarcomere organization, muscle development) with supporting signaling and trafficking roles (calcium response, receptor recycling, GTPase activity, and synaptic transmission), suggesting a unified theme of cytoskeleton-driven processes at muscle and synaptic sites.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051592","count":2},{"id":"GO:0001881","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0043982","count":1}]},{"hash":"1410342398686577981","title":"Chromatin remodeling and neural gene expression","description":"This cluster is defined by GO terms tied to chromatin organization and transcription (rDNA heterochromatin formation, nucleosome assembly, DNA-templated transcription). Additional terms point to neural context and signaling (retina development, morphine response, calcium ion release, GTPase activity regulation), as well as growth and inflammatory modulation. The convergence on chromatin control of gene expression in neural tissues best explains the functional theme across the proteins, with supporting evidence in calcium signaling and neural development cues.","confidence":"Medium","size":17,"edges":23,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0043278","count":2}]},{"hash":"1604916456290712118","title":"Lipid metabolism and signaling","description":"This cluster is dominated by lipid-related processes: triglyceride catabolism, diacylglycerol metabolism, phospholipid dephosphorylation, and sphingosine biosynthesis, plus participation in the epoxygenase P450 pathway, all pointing to lipid metabolism and lipid-derived signaling. The presence of glycolysis and calcium-mediated signaling suggests broader metabolic and signaling roles as well, but the strongest common theme across the top terms is lipid metabolism and signaling. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0046272","count":3},{"id":"GO:0046839","count":3},{"id":"GO:0019373","count":3},{"id":"GO:0097755","count":3}]},{"hash":"1890691331561641806","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The terms point to actin dynamics and cell movement: regulation of actin nucleation, negative regulation of focal adhesion assembly, fibroblast migration, and terminal web assembly, all of which tie into cytoskeletal remodeling. The EGFR and HGF signaling terms further modulate cytoskeletal changes and cell motility, while intestinal microvilli-associated terms (terminal web) link to actin-rich structures in epithelia. Collectively, these suggest a cohesive theme of actin cytoskeleton remodeling driving migration and morphological changes.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051895","count":1},{"id":"GO:0090527","count":1},{"id":"GO:0051125","count":1},{"id":"GO:0035729","count":1},{"id":"GO:0033137","count":1}]},{"hash":"585364957097590203","title":"Intestinal brush border organization and polarity","description":"This cluster is dominated by terms tied to apical cytoskeleton organization (microvilli, terminal web, Rho signaling) and epithelial junctions (tight/bicellular junctions, focal adhesions) and functions like glucose absorption and polarity signaling (Wnt). While a few GO terms reference neuronal processes, the overall theme is brush border structure and epithelial polarity in intestinal cells.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007269","count":2},{"id":"GO:0032532","count":2},{"id":"GO:0001951","count":2},{"id":"GO:0051000","count":2}]},{"hash":"242093016768051703","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0000480","count":1},{"id":"GO:0007339","count":1},{"id":"GO:0048313","count":1}]},{"hash":"1997647113884384251","title":"Apoptosis and phagocytic signaling with vesicle trafficking","description":"The cluster prominently features apoptotic process and engulfment of apoptotic cells, along with innate immune response and vesicle transport activities (COPII-coated vesicle loading, intracellular protein transport) and signaling pathways (small GTPases, integrin signaling, Ras regulation). This suggests a cohesive role in apoptotic cell clearance coupled with trafficking and signaling rather than a single linear pathway. The heart development term may reflect tissue-specific expression context rather than defining the core function of the cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0043652","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0045737","count":2},{"id":"GO:0007264","count":2}]},{"hash":"2124659696650901543","title":"Cell Division and Cytoskeleton Remodeling","description":"Top terms include sarcomere organization, membrane addition at the site of cytokinesis, Golgi inheritance, and negative regulation of meiotic cell cycle, all pointing to processes governing cell division and cytoskeletal remodeling. While transcription and ubiquitin-dependent protein degradation are general cellular processes, the recurring division/cytoskeleton themes justify this label. Some terms (sperm binding, antipsychotic response) may be incidental.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070493","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0097332","count":1},{"id":"GO:0007339","count":1}]},{"hash":"193406703698802561","title":"Cytoskeleton Dynamics and Cell Morphology","description":"This cluster centers on cytoskeletal remodeling and cell shape changes, as evidenced by GO terms like microspike assembly, positive regulation of Rho signaling, activation of GTPase activity, mitotic spindle and cilium assembly, and cell adhesion. These collectively point to actin/cytoskeleton dynamics governing morphogenesis and movement, with a few peripheral or obsolete terms that do not alter the core theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":2},{"id":"GO:0035025","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0007155","count":2}]},{"hash":"305591973370242168","title":"Brain and neural development","description":"The top terms cluster around brain development, including habenula, midbrain, forebrain neuron commitment, and locomotor behavior, indicating a neural development and brain patterning theme. Some outliers (pancreatic/endocrine development, inner ear, heart-related morphogenesis) may reflect pleiotropy or annotation noise, but the neural signal is strong.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021986","count":5},{"id":"GO:2000288","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0003309","count":5},{"id":"GO:0031018","count":5}]},{"hash":"981169904271070217","title":"Polarity-guided vesicle trafficking in development","description":"Top terms emphasize membrane trafficking (multivesicular body sorting, constitutive secretory pathway), lipid management (phospholipid homeostasis), and establishment of cell polarity, all linked with signaling (EGFR) and developmental processes (trabecula morphogenesis, dendritic cell migration). The common thread is coordinated membrane organization and trafficking that underpin cell polarization and developmental signaling.","confidence":"Medium","size":16,"edges":47,"triangles":67,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036336","count":15},{"id":"GO:1904695","count":15},{"id":"GO:0046909","count":15},{"id":"GO:0035088","count":15},{"id":"GO:0071985","count":15}]},{"hash":"774889492643021213","title":"Translation Machinery and Ribosome Regulation","description":"This cluster is dominated by GO terms related to translation and ribosome function: initiation, elongation, termination, and cytoplasmic/mitochondrial translation, plus specific aspects like selenocysteine incorporation. While a few terms touch on transcription regulation and proteasomal processes, the strongest signals point to components and regulators of protein synthesis and ribosome dynamics, including mitochondrial translation, suggesting a cohesive role in translation regulation and ribosome biology.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902416","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1901799","count":1},{"id":"GO:0032790","count":1},{"id":"GO:0006413","count":1}]},{"hash":"722866509763819291","title":"DNA maintenance and mitochondrial energy metabolism","description":"The proteins show strong GO signals for nuclear DNA processes (replication, recombination, repair, translation, ribosomal assembly) alongside mitochondrial energy-related processes (NADH to ubiquinone electron transport, ATP synthesis coupling, complex III assembly). This suggests a cluster of core cellular maintenance genes that span both genetic information processing and mitochondrial energy production, hence a combined label. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0070389","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006310","count":2}]},{"hash":"864461830731841781","title":"Vesicle trafficking and Golgi organization","description":"This cluster is characterized by GO terms focused on intermembrane transport, protein complex localization, and Golgi organization, including the cytoplasm-to-vacuole targeting (Cvt) pathway. These collectively point to a shared role in endomembrane trafficking and Golgi dynamics. Some neural development terms may be noise or cross-species annotations, but the dominant signal supports vesicle transport functions.","confidence":"Medium","size":16,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046909","count":5},{"id":"GO:0034629","count":5},{"id":"GO:0032258","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007420","count":5}]},{"hash":"2247283710410864275","title":"Viral genome integration and proviral latency","description":"The topology of GO terms centers on steps of the viral life cycle: DNA replication and recombination, DNA integration, establishment of integrated proviral latency, formation of infection structures, and viral penetration into the host nucleus. Together these terms indicate processes by which a virus delivers its genome, integrates it into the host genome, and maintains a latent provirus, with some terms likely reflecting host\u2013virus interaction and assembly steps. Although a few terms may reflect unrelated annotations (e.g., obsolete glycosylation), the dominant theme is viral genome integration and latency.","confidence":"High","size":16,"edges":80,"triangles":183,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075015","count":3}]},{"hash":"738718788048780050","title":"Neural development and sensory signaling","description":"The top terms center on oligodendrocyte differentiation, dendrite development regulation, and sensory-related responses (thermoception, muscle stretch), pointing to a theme of neural development and sensory processing. While a couple terms (salicylic acid signaling, brown fat differentiation) are peripheral, the core function appears to be neural differentiation and sensory responsiveness, with regulatory aspects that can tie into developmental processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048709","count":5},{"id":"GO:0071446","count":4},{"id":"GO:0035994","count":4},{"id":"GO:0032212","count":4},{"id":"GO:2000171","count":4}]},{"hash":"696203083746281738","title":"Vesicle Trafficking and Endosome Sorting","description":"The top GO terms cluster around endosomal pathways and vesicle dynamics: multivesicular body sorting and assembly, synaptic vesicle priming, and filopodium assembly\u2014all pointing to vesicle trafficking and cytoskeletal rearrangements. Other terms (cell cycle, mitosis exit, ERK signaling) may be general regulatory connections or indirect associations, but the dominant theme is endosome/MVB-related sorting and vesicle dynamics, justifying a vesicle trafficking-focused label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071985","count":2},{"id":"GO:0010458","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0036258","count":2},{"id":"GO:1902902","count":2}]},{"hash":"229881473065160617","title":"Seed coat and fatty acid biosynthesis","description":"The Top Terms are dominated by seed-related processes (seed coat development, seed germination, positive regulation of seed germination) and fatty acid metabolism (long-chain and very long-chain fatty acid biosynthesis/metabolic processes), which together indicate a cluster of proteins involved in seed development and lipid biosynthesis in plants. Some stress-response terms (cadmium ion response, innate immune response) may reflect broader stress signaling, but the core theme remains seed formation and lipid metabolism.","confidence":"High","size":16,"edges":20,"triangles":2,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010214","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1061782671208668509","title":"Ubiquitin-Proteasome Regulation and Signaling","description":"The cluster centers on ubiquitination and proteasome assembly (protein polyubiquitination; proteasome regulatory particle assembly) and includes several signaling pathways (B cell receptor signaling, cytokine signaling, insulin signaling, STAT phosphorylation). Additional terms like calcium import and response to mechanical stimulus suggest integration of protein turnover with broader signaling networks. Together, these terms point to a theme of protein turnover modulating signaling, justifying this label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0071260","count":2}]},{"hash":"346153222657459016","title":"Developmental signaling regulators","description":"This cluster\u2019s top GO terms cluster around developmental processes (skin development, multicellular organism development) and regulation of signaling activities (GTPase activity, serine/threonine kinase activity, protein autophosphorylation), with additional hints of cellular stress response (hypoxia) and basic processes like mRNA transport and mitotic cycling. The combination suggests proteins that act as regulators of signaling pathways during development and growth rather than a single, specific pathway. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098907","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0071902","count":4}]},{"hash":"1337070721351926836","title":"Telomere Maintenance and Telomeric Localization","description":"The cluster\u2019s top GO terms center on telomere biology\u2014telomere maintenance regulation (positive and negative), localization to the chromosomal telomeric region, telomeric DNA binding, and telomerase-related maintenance\u2014with supporting notes on poly- and auto-ADP-ribosylation, suggesting chromatin/telomere regulation as the core theme. Some terms like spindle assembly, Wnt signaling, and insulin response are present but appear less dominant, indicating a primarily telomere-focused functional theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0070198","count":2},{"id":"GO:0032212","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0070212","count":2}]},{"hash":"1084665174269808876","title":"Redox Detoxification and Toxin Response","description":"This cluster is dominated by GO terms for cellular oxidant detoxification, redox homeostasis, glutathione metabolism, and toxin response, with nucleotide-excision repair as supporting evidence. A few terms related to calcium signaling and germ cell proliferation appear peripheral, but the core theme strongly supports oxidative stress defense and detoxification.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":11},{"id":"GO:0045454","count":10},{"id":"GO:2000255","count":9},{"id":"GO:0006289","count":7},{"id":"GO:0009072","count":7}]},{"hash":"164646168537053585","title":"Ubiquitin-Proteasome Regulation and Cell Cycle Control","description":"Interpretation: The top GO terms center on ubiquitin-related processes\u2014protein deubiquitination, regulation of ubiquitin-protein ligase activity, and APC/C-dependent catabolic processes\u2014highlighting ubiquitin-driven proteolysis during mitosis. Additional terms about TNF signaling and metal/ion stress suggest integration with immune and stress responses, all linked through ubiquitin-mediated regulation.","confidence":"High","size":16,"edges":114,"triangles":481,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:0051437","count":6},{"id":"GO:0031145","count":6},{"id":"GO:0033209","count":6},{"id":"GO:0010043","count":6}]},{"hash":"649354966223227932","title":"Ribosome Biogenesis and rRNA Maturation","description":"The cluster is dominated by GO terms for maturation of both SSU and LSU rRNA and for ribosome biogenesis, indicating a cohesive role in ribosome assembly and rRNA processing. While there are additional terms related to ER-Golgi transport and chromosome-associated processes, the strongest signal centers on ribosome-related functions.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000462","count":4},{"id":"GO:0000466","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1203314162516211117","title":"Genome maintenance and RNA processing","description":"The GO terms cluster around nuclear genome maintenance (DSB repair via HR, interstrand cross-link repair, HR regulation) and RNA processing (splicing), with related nuclear transport and ubiquitination activities, suggesting a cohesive theme of genome maintenance coupled with RNA maturation. ","confidence":"Medium","size":16,"edges":15,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0071479","count":1},{"id":"GO:0000724","count":1},{"id":"GO:0036297","count":1},{"id":"GO:0010569","count":1}]},{"hash":"1384151166943936203","title":"Ubiquitin-Dependent Protein Degradation","description":"The proteins in this cluster are strongly linked to ubiquitin-mediated protein turnover, with GO terms for ubiquitin-dependent protein catabolic processes, ERAD, various forms of ubiquitination (K48-linked, polyubiquitination), and protein autoubiquitination. Although a few terms touch on X chromosome inactivation and peroxisomal import, the dominant theme is tagging substrates for proteasomal degradation via the ubiquitin-proteasome system.","confidence":"High","size":16,"edges":2,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0030433","count":8},{"id":"GO:1900095","count":7},{"id":"GO:0051865","count":7},{"id":"GO:0046621","count":7}]},{"hash":"1143443102666373678","title":"Lipid catabolism and endocannabinoid signaling","description":"The top GO terms are dominated by lipid catabolic processes (triglyceride, diacylglycerol, monoacylglycerol, phosphatidylserine, cholesterol catabolic), with additional relevance to regulation of endocannabinoid signaling. A few terms related to the cytoskeleton and cell cycle are present but less central, so the core theme appears to be lipid metabolism and lipid-derived signaling rather than a single cohesive non-lipid function. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0051017","count":3},{"id":"GO:2000124","count":2},{"id":"GO:0046340","count":2}]},{"hash":"2170861518380394537","title":"Steroid and lipid biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for steroids (testosterone, glucocorticoids, androgens) and lipids/vitamins (retinol/retinal, sphingolipids), pointing to a core theme of steroid and lipid metabolism. While a couple of terms relate to broader biosynthesis (antibiotics, PHB), the shared function across the cluster appears to be production of lipid- and steroid-derived molecules, with transcriptional regulation as a secondary association.","confidence":"High","size":16,"edges":20,"triangles":8,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0006355","count":8},{"id":"GO:0061370","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0042574","count":8}]},{"hash":"1685881577253234750","title":"Ubiquitin-Dependent Immune Signaling","description":"Most terms point to ubiquitin-mediated protein turnover and signaling (ubiquitin-dependent protein catabolic process, autoubiquitination, histone ubiquitination) together with innate antiviral defense and inflammatory pathways (defense response to virus, innate immune response, TNF signaling, JNK cascade). This suggests the cluster groups proteins involved in ubiquitin-regulated immune signaling rather than a single pathway, with an outlier annotation related to X chromosome dosage compensation. Therefore this label captures the common thread of ubiquitination-linked control of immune responses.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:1903762","count":5},{"id":"GO:0051865","count":5},{"id":"GO:1901253","count":5},{"id":"GO:0046328","count":4}]},{"hash":"2099825831425054199","title":"Meiotic DNA Repair and Chromosome Segregation","description":"The top GO terms are dominated by meiotic processes (meiotic cell cycle, meiotic DSB formation, DSB repair via homologous recombination, sister chromatid exchange, meiotic chromosome condensation, and nuclear chromosome segregation), indicating a cohesive focus on meiosis and genome maintenance during chromosome segregation. Occasional terms like ubiquitin recycling and mitochondrial translation are less central but do not override the main meiotic theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010992","count":2},{"id":"GO:0032543","count":1},{"id":"GO:1990414","count":1},{"id":"GO:0000724","count":1},{"id":"GO:0051321","count":1}]},{"hash":"1577637467007644649","title":"Neuronal development and synaptic signaling","description":"This cluster centers on nervous system development and synaptic regulation, with terms for neural development, regulation of synapse structure/activity, axon guidance, collateral sprouting, and ionotropic glutamate receptor signaling. Calcium homeostasis in the ER also supports neuronal signaling, reinforcing a neural connectivity theme. A few morphogenesis terms may reflect broader developmental processes, but the dominant signal is neural development and synaptic function.","confidence":"High","size":15,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":1},{"id":"GO:0050803","count":1},{"id":"GO:1990000","count":1},{"id":"GO:0048669","count":1},{"id":"GO:0010951","count":1}]},{"hash":"852314020324207490","title":"Development and Proliferation Regulation","description":"This cluster is enriched for GO terms spanning developmental processes across tissues (root development, ectoderm development, CNS vasculogenesis, lung induction, prostate gland epithelial proliferation) and for regulation of cell growth and the cell cycle (regulation of cell cycle, negative regulation of cell population proliferation). The mix suggests a cohesive theme of development coupled with control of proliferation. The inclusion of nuclear import and mitochondrial calcium regulation may reflect associated cellular remodeling during growth.","confidence":"Medium","size":15,"edges":95,"triangles":343,"max_degree":14,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":9},{"id":"GO:0048364","count":9},{"id":"GO:0007050","count":9},{"id":"GO:0060492","count":8},{"id":"GO:0008285","count":8}]},{"hash":"647492825275344249","title":"Neural sensory processing and dopaminergic signaling","description":"The top GO terms cluster around sensory perception (pain, vision, learning), dopaminergic synaptic transmission, and behavioral responses to drugs like cocaine, plus ERK signaling, which together point to neural sensory processing and reward pathways. Peripheral terms like heart development or thermogenesis appear less central to the core theme, but do not override the main neural/signaling pattern.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0007601","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0007507","count":6}]},{"hash":"2024761859393217900","title":"Sarcomere Assembly and Muscle Contraction Regulation","description":"The cluster\u2019s top terms largely center on sarcomere organization, cardiac myofibril assembly, and regulation of skeletal muscle contraction, suggesting a shared role in building and controlling the muscle contractile apparatus. Supporting terms about cytoskeletal transport and related signaling pathways reinforce a broader theme of muscle fiber organization and function, with some neuronal terms present but not dominant. Overall, the dominant signal points to muscle structure and contractile machinery.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043001","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0055003","count":2},{"id":"GO:0048384","count":2},{"id":"GO:0061368","count":2}]},{"hash":"1908344811529804941","title":"Embryonic organogenesis and tissue differentiation","description":"This cluster centers on developmental processes across multiple tissues\u2014kidney, skin, placenta, cartilage, and fat\u2014along with related signaling (intracellular signaling, JAK-STAT) that underpins organogenesis and tissue differentiation. The mix of tissue-development terms, plus a broader signaling term, suggests a general theme of embryonic organ formation rather than a single specialized function, though the thermoception term is an outlier likely reflecting sensory development context. Overall, a multi-tissue developmental cluster is the best-fit interpretation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050960","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0035556","count":2}]},{"hash":"1077413209058973453","title":"Embryonic Organ Development","description":"The top GO terms point to broad developmental processes across multiple organs (lung morphogenesis, uterus development, neural crest migration, eye and mouth development, heart outflow tract morphogenesis, etc.) and transcription regulation by RNA polymerase II. This suggests the proteins are enriched for roles in regulating gene expression during embryogenesis across diverse tissues, rather than a single, specific pathway. The lack of network edges aligns with a shared functional theme based on developmental processes rather than direct interactions.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0060441","count":8},{"id":"GO:0060065","count":8},{"id":"GO:0007338","count":8},{"id":"GO:0006366","count":8}]},{"hash":"125415102084441855","title":"Multicellular development and differentiation","description":"This cluster\u2019s top GO terms are dominated by developmental processes across tissues (neuron projection development, lens fiber cell differentiation, skeletal system development, and general multicellular organism development), suggesting a coherent theme around development and differentiation. A few terms (ribosomal biogenesis, adhesion, signaling) appear less specific and may reflect broad cellular roles or incidental associations.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0042273","count":2}]},{"hash":"2302540670513937802","title":"Translation machinery and ribosome biogenesis","description":"This cluster is dominated by translation-related processes: overall translation, translation initiation and termination, maturation of rRNA for SSU, and mitochondrial translation, plus selenocysteine incorporation and positive regulation of cytoplasmic translation, indicating a core association with ribosome function and protein synthesis.","confidence":"High","size":15,"edges":102,"triangles":418,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0000462","count":6},{"id":"GO:0046677","count":4},{"id":"GO:0006413","count":3},{"id":"GO:0006415","count":3}]},{"hash":"2254576186239728104","title":"Neural development and redox-stress signaling","description":"The cluster shows strong neural development signals (substantia nigra development, in utero embryonic development, regulation of axonogenesis) together with redox and stress-related responses (redox homeostasis, oxidation\u2013reduction processes, corticosterone and xenobiotic responses). Rab signaling and proliferation terms support trafficking and growth during development, reinforcing a focus on neural development intertwined with redox and stress pathways. ","confidence":"Medium","size":15,"edges":33,"triangles":33,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0021762","count":5},{"id":"GO:0045454","count":5},{"id":"GO:0050771","count":4},{"id":"GO:0032482","count":4}]},{"hash":"741923640202161425","title":"Glycinergic signaling and glial growth","description":"The top GO terms emphasize glycinergic neurotransmission (glycine secretion; glycinergic synaptic transmission) and perineurial glial growth, with supporting evidence from amino acid transport (taurine, leucine). This suggests a neural-support cluster centered on inhibitory glycine signaling and glial development around neurons. Several broader development terms (endothelial barrier, uterus development, Wnt signaling) appear less directly tied to the core theme, so the strongest, most representative signal is neural signaling and glial growth.","confidence":"Medium","size":15,"edges":19,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0090557","count":2},{"id":"GO:0010667","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0061537","count":1}]},{"hash":"1041898941703093196","title":"Translation machinery and ribosome assembly","description":"The cluster is dominated by GO terms tied to translation (translation, translational initiation, termination, elongation) and ribosome components/assembly (ribosomal large subunit assembly; selenocysteine incorporation as part of translational machinery). Positive regulation of cytoplasmic translation and translational elongation further support a role in protein synthesis. A few terms like response to antibiotic and glial cell proliferation are peripheral or reflect broader regulatory connections or dataset noise, but do not override the central translation theme.","confidence":"High","size":15,"edges":103,"triangles":429,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0046677","count":4},{"id":"GO:0006413","count":3},{"id":"GO:0006415","count":3},{"id":"GO:0000027","count":3}]},{"hash":"1573337524773210565","title":"Adaptive immune response and phagocytosis","description":"The top GO terms prominently include adaptive immune response and phagocytosis, with neutrophil clearance also represented, suggesting an immune-activation/phagocytic function. Calcium ion transport and phosphorylation indicate signaling relevant to immune cell responses, while other terms like DNA replication or mitotic checkpoint signaling seem less connected to the main theme. Overall, the cluster is best described by immune activation and phagocytic processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070588","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0015966","count":2},{"id":"GO:0006909","count":2}]},{"hash":"1049305548777986760","title":"Ubiquitin-Dependent Degradation and Antiviral Immunity","description":"The proteins appear to cluster around ubiquitin-mediated proteolysis (ubiquitin-dependent catabolic processes, autoubiquitination, ERAD, and K63/K11-linked ubiquitination) with accompanying innate immune and antiviral defense terms, suggesting a core theme of ubiquitin-regulated protein turnover linked to immune signaling. Some immune-related terms extend to B cell signaling, and there is also an unfolded protein response component, but the dominant pattern is ubiquitin-dependent degradation connected to immune defense.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0045087","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0050853","count":4}]},{"hash":"267423380091249487","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":61,"triangles":169,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":8},{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0048025","count":7},{"id":"GO:0006412","count":7}]},{"hash":"597746370765472912","title":"Vesicle trafficking and developmental regulation","description":"This cluster shows GO terms clustered around membrane and vesicle trafficking (synaptic vesicle coating, clathrin-dependent endocytosis, intracellular protein transport) alongside several development/regulation terms (hemocyte differentiation, mesoderm development, blood vessel remodeling, intestinal epithelial development, neuronal channel clustering). The common thread is a mix of cellular trafficking functions with broader developmental and differentiation roles, suggesting proteins that participate in membrane trafficking coupled with developmental regulation rather than a single narrow pathway. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016183","count":1},{"id":"GO:0072583","count":1},{"id":"GO:0006886","count":1},{"id":"GO:0045610","count":1},{"id":"GO:0060576","count":1}]},{"hash":"368057340233049389","title":"Potassium Ion Transport and Homeostasis","description":"The cluster's most recurring GO terms are about potassium ions being transported across the plasma membrane and maintaining intracellular potassium levels (import/export, transmembrane transport, and homeostasis). A related term on membrane potential changes aligns with ion-channel\u2013mediated activity in neurons, while several temperature/pain terms may reflect sensory neuron signaling that also depends on ion flux. Overall, the dominant theme is potassium transport and homeostasis.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097623","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0030007","count":4}]},{"hash":"1204520843572469533","title":"Cell proliferation and ER-Golgi transport","description":"The cluster\u2019s top GO terms are dominated by mitotic cell cycle, cell division, and cell population proliferation, indicating a primary focus on growth and division. They are complemented by vesicle trafficking terms (ER to Golgi, COPII budding, endosome-to-Golgi), tying growth to secretory pathway dynamics; TORC1 signaling also points to growth regulation. Together, these suggest a coordinated role in proliferation and secretory transport.","confidence":"High","size":15,"edges":14,"triangles":0,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006888","count":3},{"id":"GO:1904263","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1955074878126395947","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0061158","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0043123","count":2}]},{"hash":"532072396363914141","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic processes, indicating the cluster centers on protein turnover via ubiquitin-proteasome pathways. While additional terms touch on nervous system development and sarcomere/muscle-related processes, the strongest and most consistent signal is ubiquitin-mediated degradation, justifying this label.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0006511","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0042748","count":2},{"id":"GO:2000312","count":2}]},{"hash":"879688832082835621","title":"Choline/ethanolamine phospholipid biosynthesis (Kennedy pathway)","description":"The proteins are enriched for GO terms tied to choline and ethanolamine metabolism and the CDP-choline pathway, which together define the Kennedy pathway for phospholipid biosynthesis (phosphatidylcholine and phosphatidylethanolamine). While there are some stress-response terms present, the dominant signal is membrane lipid production.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019695","count":1},{"id":"GO:1904681","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006646","count":1},{"id":"GO:0006657","count":1}]},{"hash":"869729505716874850","title":"RNA Splicing and Translation Initiation","description":"Top GO terms cluster around RNA metabolism: translation reinitiation and formation of translation preinitiation complexes point to initiation steps in protein synthesis, while multiple terms relate to RNA processing and maturation via the spliceosome (cis and alternative splicing regulation) and small-subunit processome assembly, plus mRNA export from the nucleus. The presence of regulatory ncRNA-mediated gene silencing also ties into RNA-based regulation. A developmental term (blastocyst formation) appears but likely reflects broader roles of RNA processing in development. Overall, it captures a theme of RNA processing and translation initiation machinery.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:1903586","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0006406","count":2}]},{"hash":"749776455337148267","title":"Membrane Transporters for Ions and Sugars","description":"This cluster is dominated by GO terms for transmembrane transport, including sodium and potassium ion transport, phosphate ion transport, and various sugar and xenobiotic transports, suggesting a group of proteins acting primarily as membrane transporters handling ions and small molecules. The diversity of substrate-related transport terms indicates a cohesive transport function rather than a single substrate specialization, supporting a label of membrane transporters for ions and sugars.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0035435","count":3},{"id":"GO:0006004","count":3},{"id":"GO:0015739","count":3}]},{"hash":"770344579895474164","title":"Developmental Cell Polarity and Trafficking","description":"This cluster centers on cell polarity and morphogenesis, underpinned by membrane trafficking and lipid homeostasis. Key terms include apical/basal polarity maintenance, trabecula morphogenesis, and multivesicular body sorting, with membrane composition supporting these processes. Some terms touch on development and cell migration (spermatid development, dendritic cell migration), but the common thread is how polarity and trafficking coordinate tissue morphogenesis.","confidence":"Medium","size":14,"edges":8,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045740","count":4},{"id":"GO:0007286","count":4},{"id":"GO:0036336","count":3},{"id":"GO:1904695","count":3},{"id":"GO:0046909","count":3}]},{"hash":"389664293325229564","title":"ER stress response and apoptotic regulation","description":"The proteins in this cluster are enriched for GO terms related to cellular response to unfolded protein and ER-stress\u2013related apoptotic signaling, as well as negative regulation of intrinsic apoptosis under oxidative stress. This points to a core theme of proteostasis and cell survival under stress, with supporting terms about post-translational targeting to membranes and GTPase regulation that may modulate signaling or trafficking. While a few terms (morphogenesis, karyogamy) are peripheral, the dominant pattern centers on stress response and apoptotic control.","confidence":"Medium","size":14,"edges":12,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0090084","count":2},{"id":"GO:0000902","count":2},{"id":"GO:0034620","count":2},{"id":"GO:1902037","count":2}]},{"hash":"1381434335140998826","title":"Mitotic progression and proliferation signaling","description":"This cluster concentrates on cell cycle advancement and growth, with GO terms for G1/S transition, mitotic spindle regulation, and re-entry into the cell cycle, alongside DNA-templated transcription and proliferation-related processes (e.g., mammary gland epithelial cell proliferation, insulin signaling). The presence of an ER unfolded protein response suggests coupling between stress responses and division. Overall, these proteins appear to coordinate cell division and proliferation signals.","confidence":"High","size":14,"edges":76,"triangles":215,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032026","count":7},{"id":"GO:0030968","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0010696","count":5}]},{"hash":"1397047597254050274","title":"Skeletal and neural development","description":"These proteins show a developmental theme, with strong representation of skeletal system development and osteoblast differentiation, plus brain development and multicellular organism development. Additional terms point to TGF-beta\u2013mediated signaling and transcriptional regulation during development, suggesting a module coordinating bone formation and neural development within multicellular growth processes.","confidence":"High","size":14,"edges":10,"triangles":1,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0007568","count":7},{"id":"GO:0071560","count":7},{"id":"GO:0006349","count":7},{"id":"GO:0001501","count":7}]},{"hash":"921725384183456880","title":"mRNA processing and transcription regulation","description":"The predominant GO terms cluster around mRNA processing/export, transcription regulation, and processing-body dynamics, indicating a cluster of nuclear RNA metabolism and gene expression control. A few terms on phosphorylation and innate immunity are auxiliary.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0010606","count":2},{"id":"GO:1903070","count":2},{"id":"GO:0006351","count":2}]},{"hash":"816340696815320426","title":"Translational initiation and ribosome maturation","description":"The dominant GO terms are about translation initiation complex formation, translation reinitiation, and maturation of 5.8S rRNA, pointing to ribosome assembly and protein synthesis as the core shared function. Additional terms on development and transcription suggest broader roles, but the strongest signal centers on the translation machinery. With no interaction edges observed, this label best captures the primary theme of the cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0000466","count":3},{"id":"GO:0030433","count":3}]},{"hash":"291064027936639864","title":"Developmental and neural signaling pathways","description":"The terms center on diverse signaling cascades (Roundabout/ROBO, T cell receptor, Smoothened/Hedgehog, ERK/MAPK) and processes related to nervous system development and synaptic function, indicating a cluster of proteins involved in broad developmental and neural signaling networks, despite some immune-related terms.","confidence":"Medium","size":14,"edges":67,"triangles":147,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0001822","count":4},{"id":"GO:0070374","count":4}]},{"hash":"2238598965778209863","title":"Spliceosome Assembly and Translation Initiation","description":"Top GO terms center on translation reinitiation and preinitiation complex formation, plus multiple RNA processing activities including spliceosome-mediated and other mRNA splicing processes, mRNA export, and small-subunit processome assembly. This pattern suggests a cohesive set of RNA metabolism factors that coordinate mRNA maturation with translation initiation, justifying a label that emphasizes both splicing and initiation steps.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:1903586","count":5}]},{"hash":"1150774346471333348","title":"Sensory Signaling and Potassium Homeostasis","description":"The top GO terms show sensory perception (pain and vision), regulation of photoreceptor signaling, and GPCR internalization, along with potassium ion transport and homeostasis. Temperature-related terms (thermogenesis, temperature stimulus) further point to activity-dependent signaling environments, likely neural or sensory-cell contexts. Heart development appears secondary to these core signaling and ionic balance processes. Overall, the cluster centers on sensory signal transduction with ion (potassium) homeostasis.","confidence":"Medium","size":14,"edges":19,"triangles":5,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0002024","count":6},{"id":"GO:0071502","count":6},{"id":"GO:1990573","count":5},{"id":"GO:0030007","count":5}]},{"hash":"1081418400870476314","title":"Liver metabolism and regeneration signaling","description":"The cluster\u2019s top GO terms point to hepatic metabolic processes (sterol biosynthesis; regulation of insulin signaling; hydrogen peroxide metabolism) and signaling pathways that drive cell-cycle control and regeneration (activation of GTPase activity; positive regulation of CDK activity; explicit liver regeneration). Taken together, the proteins appear to coordinate liver-specific metabolism with regenerative signaling and oxidative stress responses, making this a coherent hepatic metabolism-regeneration cluster.","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":2},{"id":"GO:0016126","count":2},{"id":"GO:0046626","count":2},{"id":"GO:0045737","count":2},{"id":"GO:0097421","count":2}]},{"hash":"1197161497675413128","title":"Transcription Regulation by Pol II/III and SMAD","description":"The top GO terms are centered on transcription control (positive regulation of transcription by RNA polymerase II/III, preinitiation complex assembly) and SMAD signaling, pointing to regulation of gene expression. Other terms touch on development and neural signaling, which can be downstream effects of transcriptional regulation, supporting a general theme of transcriptional regulation and signaling rather than a single pathway. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075297","count":1},{"id":"GO:0060395","count":1},{"id":"GO:0045945","count":1},{"id":"GO:0070898","count":1},{"id":"GO:0060261","count":1}]},{"hash":"512527405246987","title":"Epithelial polarity and adherens junction dynamics","description":"The cluster is strongly associated with maintenance of epithelial cell apical/basal polarity (GO:0045199), zonula adherens assembly (GO:0045186), and protein localization to the basolateral membrane (GO:1903361), pointing to processes that organize cell junctions and polarity. Additional terms like exocytosis (GO:0006887) and regulation of Wnt signaling (GO:0030111) fit with membrane trafficking and signaling that intersect with junctional complexes. Some terms (e.g., synaptic depression, light perception, NOD2 pathway regulation) appear more peripheral or noisy relative to the core polarity/junction theme, but the dominant signal supports epithelial polarity and junction maintenance.","confidence":"Medium","size":14,"edges":48,"triangles":93,"max_degree":12,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0070433","count":5},{"id":"GO:0050821","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0045199","count":4},{"id":"GO:0030111","count":4}]},{"hash":"1574563489941982364","title":"Embryonic craniofacial and skeletal development","description":"The top GO terms center on embryonic development of cranial structures and the skeleton (embryonic cranial skeleton morphogenesis, osteoblast and cartilage development, roof of the mouth), along with brain and inner ear development and heart-related morphogenesis. This suggests a cohesive module focused on craniofacial skeletal formation and adjacent organogenesis during embryogenesis, despite some broader terms.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003148","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0048839","count":4},{"id":"GO:0060065","count":3}]},{"hash":"1620941245831085281","title":"Cell Cycle and Mitochondrial Regulation","description":"This cluster centers on core cell cycle processes (cell division, DNA replication, G1/S transition control) and mitochondrial-associated functions (protein import into the mitochondrial matrix, regulation of mitochondrial membrane permeability). Additional terms like UV protection and oogenesis add developmental and stress-response context but still fit within a broader theme of coordinating growth with mitochondrial energy status and genome maintenance. Thus, the label reflects the predominant themes of cell-cycle control integrated with mitochondrial function.","confidence":"Medium","size":14,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0048477","count":2},{"id":"GO:0009650","count":2},{"id":"GO:2000134","count":2}]},{"hash":"1054746723576796824","title":"Histone acetylation and transcription regulation","description":"The top GO terms center on histone acetylation (H4K5/K8/K12; H3) and regulation of transcription by RNA polymerase II, pointing to chromatin modification as a core feature of this cluster. A few terms also relate to RNA processing events (splicing, translation initiation, ribosome biogenesis), suggesting broader involvement in gene-expression control. Overall, the dominant theme is chromatin modification coupled with transcription regulation, with some peripheral links to RNA processing. ","confidence":"Medium","size":14,"edges":15,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0043981","count":4},{"id":"GO:0043982","count":4},{"id":"GO:0043966","count":4},{"id":"GO:0006357","count":3},{"id":"GO:0043983","count":3}]},{"hash":"457677651300878372","title":"Blood cell differentiation and reproductive development","description":"The cluster\u2019s top GO terms center on differentiation of hematopoietic lineages (erythrocyte, megakaryocyte) and reproductive tissues (female gonad, uterus), suggesting a theme around developmental differentiation in blood and reproductive systems. However, several terms are obsolete or unrelated (nitrate assimilation, camphor catabolic process), indicating some annotation noise. Confidence: Medium","confidence":"","size":14,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034720","count":2},{"id":"GO:0045654","count":2},{"id":"GO:0010725","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0019383","count":2}]},{"hash":"1570905430766706703","title":"Diverse metabolite biosynthesis","description":"GO terms are dominated by biosynthetic processes across steroids, retinoids, lipids, antibiotics, and polymers like poly-hydroxybutyrate, with one transcription regulation term as a minor addition. This points to a common theme of metabolite production rather than a single pathway, justifying the label \"Diverse metabolite biosynthesis.\" ","confidence":"High","size":14,"edges":12,"triangles":3,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0006355","count":6},{"id":"GO:0061370","count":6},{"id":"GO:0017000","count":6},{"id":"GO:0042574","count":6}]},{"hash":"1426967043800005330","title":"Retinal Dopaminergic GPCR Signaling","description":"The core terms point to dopamine-mediated signaling and GPCR pathways in the retina, supporting roles in visual processing and dopaminergic synaptic transmission. Retina development and visual learning terms suggest a retinal module linked to vision, while dopaminergic signaling and dopamine metabolism tie to brain reward pathways as reflected by cocaine response. The other terms (macrophage chemotaxis, cell proliferation, GTPase regulation) are more general regulatory processes that do not override the main theme. Therefore, the cluster seems best described as a retinal dopaminergic GPCR signaling module.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0008542","count":4},{"id":"GO:0071880","count":3},{"id":"GO:0001973","count":3},{"id":"GO:0048148","count":3}]},{"hash":"836163458743067837","title":"Core gene expression and development machinery","description":"This cluster centers on fundamental gene expression processes\u2014DNA-templated transcription, ribosome biogenesis, and translation\u2014and includes mitotic cell cycle activity. It also features development-related terms (forebrain development, neural tube closure, multicellular organism development), suggesting a subset of proteins with roles in growth and development alongside core expression machinery. Overall, the shared themes point to a group focused on transcription/translation machinery with developmental regulation.","confidence":"Medium","size":13,"edges":74,"triangles":246,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0006349","count":3}]},{"hash":"1973263120444251572","title":"Phosphorylation and Ubiquitination Signaling","description":"The cluster is dominated by terms about phosphorylation/dephosphorylation and ubiquitination, with related regulation of kinase activity and GTPase signaling, plus cytoskeletal transport and muscle-related assembly terms, suggesting a theme of post-translational modification\u2013driven signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0006470","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0071902","count":3},{"id":"GO:0031954","count":3}]},{"hash":"1885891876723342925","title":"Podocyte Function and Lipid Signaling","description":"This cluster is mainly tied to kidney podocyte biology (metanephric podocyte development; cadherin-mediated cell-cell adhesion; excretion) and processes related to lipid regulation (negative regulation of cholesterol biosynthesis; SREBP signaling). Mitochondrial dynamics and proteolysis regulation add cellular energy and protein turnover context, which can intersect podocyte physiology and membrane/cytoskeletal remodeling. While a few terms are less directly related (e.g., dopaminergic synaptic transmission), the core theme centers on podocyte function with supporting lipid signaling and mitochondrial dynamics.","confidence":"Medium","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045541","count":10},{"id":"GO:0072249","count":10},{"id":"GO:0032226","count":10},{"id":"GO:0001302","count":10},{"id":"GO:0045861","count":10}]},{"hash":"2141942573346595131","title":"Cerebellar development and synaptic maturation","description":"These proteins cluster around cerebellar-specific developmental processes and synaptic function: cerebellar cortex formation, Bergmann glial differentiation, axonogenesis, and long-term synaptic potentiation with excitatory postsynaptic potentials. Insulin receptor signaling and apoptotic regulation support neuronal development and survival, while the kinetochore term is an outlier. Together, they point to cerebellar neuronal development and synaptic maturation.","confidence":"Medium","size":13,"edges":24,"triangles":6,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0060020","count":4},{"id":"GO:0021697","count":4}]},{"hash":"1189429980456066127","title":"LDL receptor\u2013mediated cholesterol transport regulation","description":"Proteins in this cluster show strong enrichment for GO terms related to LDL receptor activity and its regulation, including negative and positive regulation of LDL receptor\u2013mediated endocytosis and related cholesterol transport processes. This points to a shared role in cholesterol homeostasis via LDL receptor pathways. A few terms about embryonic axis determination and sporulation appear, likely as annotations from unrelated contexts or minor cross-species associations, but the dominant signal centers on LDL receptor\u2013dependent cholesterol handling.","confidence":"High","size":13,"edges":15,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007354","count":2},{"id":"GO:0010989","count":2},{"id":"GO:1905601","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0034230","count":2}]},{"hash":"85730974577966896","title":"Mitochondrial transporters and dynamics","description":"These terms collectively describe mitochondrial metabolite transport across the inner membrane (ADP, NAD, alpha-ketoglutarate, phosphate, heme) along with membrane remodeling and stress responses (fission, apoptotic changes, superoxide response), plus adaptive thermogenesis. The pattern strongly points to a cluster of mitochondrial carrier proteins and regulators governing energy metabolism and mitochondrial remodeling.","confidence":"High","size":13,"edges":17,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090149","count":9},{"id":"GO:0000002","count":9},{"id":"GO:0015742","count":8},{"id":"GO:1990845","count":8},{"id":"GO:0015886","count":8}]},{"hash":"1134793727314685631","title":"Mitotic microtubule dynamics and cytokinesis","description":"The top GO terms center on microtubule-based processes: plus-end-directed vesicle transport, microtubule depolymerization, centrosome separation, chromosome alignment, and actomyosin contractile ring assembly\u2014all key components of mitosis and cytoskeletal remodeling. A few terms about development (root development, ureteric bud invasion) suggest these microtubule-driven mechanisms also underpin tissue development. Together, they point to microtubule dynamics driving cell division and associated morphogenesis.","confidence":"High","size":13,"edges":18,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1990535","count":3},{"id":"GO:0048364","count":3},{"id":"GO:0001560","count":3},{"id":"GO:0007100","count":3},{"id":"GO:0000915","count":3}]},{"hash":"550404325608724897","title":"Glycinergic neurotransmission and amino acid transport","description":"The cluster is dominated by terms tied to glycinergic signaling (synaptic transmission, glycinergic; glycine secretion and neurotransmission) and various amino acid transport processes (taurine, leucine, serotonin uptake). The presence of brain-related terms like thalamus development and perineurial glial growth supports a neuronal/glial context, suggesting a coherent theme of neurotransmission coupled with amino acid transport. The translation term appears as a generic component and is less specific to this theme, so the core signal remains glycinergic signaling with amino acid transport.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0061537","count":1},{"id":"GO:0015734","count":1},{"id":"GO:0015820","count":1},{"id":"GO:0042066","count":1}]},{"hash":"1927564497622010528","title":"Auditory neuron axon guidance and synapse assembly","description":"This cluster is dominated by GO terms related to sound perception and detection of mechanical stimuli, along with axon extension, axon guidance, synapse organization, and paranodal/juxtaparanode region localization. Together these indicate proteins involved in auditory neuron development, axon pathfinding, and formation/organization of synapses in myelinated nerves. Confidence: High","confidence":"","size":13,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":4},{"id":"GO:0048675","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0050808","count":3}]},{"hash":"2228840295812678505","title":"CNS Development and ECM/Adhesion","description":"The proteins in this cluster are mainly annotated with neural development topics (axon development, astrocyte development, substantia nigra development, CNS myelination) and processes related to the extracellular matrix and focal adhesion assembly, suggesting a shared theme of CNS development paired with cell-matrix interactions. While some terms (bone mineralization, fatty acid biosynthesis, phototaxis) are less directly connected, they do not outweigh the dominant neural-ECM signal. The label reflects the core functional themes represented by the top GO terms.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030501","count":1},{"id":"GO:0051893","count":1},{"id":"GO:0042759","count":1},{"id":"GO:0022010","count":1},{"id":"GO:0021762","count":1}]},{"hash":"1577396736393730580","title":"Unknown","description":"The listed GO terms are scattered across nucleotide transport, lipid metabolism, various (obsolete) Wnt signaling annotations related to cell adhesion and wound healing, germ cell repulsion, endothelial migration, and oxidant detoxification, with no shared biological process or pathway and no interactions among proteins. This lacks a coherent theme to name the cluster, so it\u2019s Unknown with None confidence. ","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015862","count":1},{"id":"GO:0035364","count":1},{"id":"GO:0006670","count":1},{"id":"GO:0044329","count":1},{"id":"GO:0035233","count":1}]},{"hash":"1359741613004692875","title":"Mitochondrial oxidative phosphorylation and ATP synthesis","description":"This cluster centers on mitochondrial energy metabolism, with strong representation of oxidative phosphorylation, electron transport chain steps, proton translocation, and ATP production, indicating a cohesive theme of mitochondrial respiration. Occasional terms like bradykinin catabolism and ER unfolded protein response are present but less representative of the core function.","confidence":"High","size":12,"edges":13,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006119","count":2},{"id":"GO:0019646","count":2},{"id":"GO:0006122","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0010815","count":2}]},{"hash":"2041605782855120961","title":"Membrane Trafficking & Polarity","description":"Most top GO terms cluster around intracellular membrane dynamics: multivesicular body sorting, the constitutive secretory pathway, and establishment/maintenance of apical/basal cell polarity, with supporting roles for phospholipid homeostasis. These together point to a membrane trafficking/polarity function. A few terms (dendritic cell migration, trabecula morphogenesis) are broader or indirect but can relate to cell movement and tissue morphogenesis, complementing the main theme.","confidence":"High","size":12,"edges":14,"triangles":1,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036336","count":10},{"id":"GO:1904695","count":10},{"id":"GO:0046909","count":10},{"id":"GO:0035088","count":10},{"id":"GO:0071985","count":10}]},{"hash":"884352359645419212","title":"Unknown","description":"Top terms span neuronal plasticity, B cell signaling, endothelial barrier and tight junction assembly, membrane organization, and neural development. The broad mix shows no single, cohesive function for the cluster, so a precise label cannot be inferred.","confidence":"","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":1},{"id":"GO:0050861","count":1},{"id":"GO:0061028","count":1},{"id":"GO:0070830","count":1},{"id":"GO:0035208","count":1}]},{"hash":"1862223212344312336","title":"DNA Damage Response and Cell Cycle Control","description":"The cluster is enriched for terms tying DNA damage sensing and repair (mismatch repair, p53-mediated apoptotic signaling), DNA-templated transcription regulation, and cell cycle processes, with apoptotic outcomes upon DNA damage. A development term appears but is less representative. This suggests a module coordinating DNA damage response, transcriptional control, and cell cycle regulation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043046","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0021555","count":2}]},{"hash":"1404464044538896186","title":"Cardiac muscle development and function","description":"This cluster is dominated by heart-related terms: heart development, cardiac muscle contraction, cardiac myofibril assembly, and actin crosslink formation, pointing to sarcomere structure and cardiac muscle function. Additional signals such as positive regulation of nitric-oxide synthase and guanylate cyclase activity suggest regulatory pathways relevant to cardiac signaling. A neural term appears less central, but the cardiac-focused terms prevail. ","confidence":"High","size":12,"edges":13,"triangles":2,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051000","count":4},{"id":"GO:0060048","count":4},{"id":"GO:1902896","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1405493562503572051","title":"Multicellular development and differentiation","description":"The top GO terms cluster around developmental processes across tissues (neuron projection development, lens fiber cell differentiation, skeletal system development, multicellular organism development), with a supplementary signal from cell division and gene expression-related terms. This suggests the proteins participate in developmental differentiation in a multicellular context more than a single targeted process. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000920","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1248786291783845608","title":"Chromatin acetylation and organization","description":"This cluster centers on acetylation-based chromatin regulation, including histone acetylation, heterochromatin formation, and various N- and polyamine acetylations, with supporting links to centromeric cohesion and chromatin organization. Some developmental terms (leaf formation) and angiogenesis may reflect broader annotations, but the dominant theme is chromatin modification via acetylation.","confidence":"High","size":12,"edges":20,"triangles":9,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":8},{"id":"GO:0043967","count":7},{"id":"GO:0032920","count":7},{"id":"GO:0046208","count":7},{"id":"GO:0017196","count":7}]},{"hash":"879165015988604363","title":"RNA Pol II Transcription Regulation","description":"Most GO terms point to RNA polymerase II\u2013dependent transcription, covering initiation, promoter clearance, elongation, and mRNA capping, with an additional entry about viral transcription. That shared function indicates the cluster represents proteins involved in regulating or executing transcription by RNA Pol II rather than a single specific downstream process.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":1},{"id":"GO:0010467","count":1},{"id":"GO:0042795","count":1},{"id":"GO:0001111","count":1},{"id":"GO:0006368","count":1}]},{"hash":"1055548911492970329","title":"Central carbon metabolism and amino acid catabolism","description":"This cluster is dominated by core metabolic processes such as the TCA cycle, glyoxylate cycle, and oxaloacetate metabolism, along with several amino acid catabolic pathways (alanine and kynurenine/tryptophan). The presence of these energy-generation and amino-acid turnover terms suggests a cohesive metabolic module, though the Notch signaling term and some obsolete annotations appear as noise. Confidence reflects this partial alignment with metabolism rather to signaling.","confidence":"Medium","size":12,"edges":64,"triangles":200,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006107","count":6},{"id":"GO:0019878","count":6},{"id":"GO:0007219","count":5},{"id":"GO:0097053","count":5},{"id":"GO:0042853","count":5}]},{"hash":"835703771256046649","title":"Neuronal development and sensory signaling","description":"The top GO terms center on neural functions: sensory perception (pain, vision), dopaminergic synaptic transmission, and signaling pathways (ERK cascade, prostaglandin response). Developmental and transcription-related terms are present but secondary, suggesting the cluster mainly represents neuronal signaling and sensory processing with supporting developmental context.","confidence":"Medium","size":12,"edges":55,"triangles":129,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0046827","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0007601","count":7}]},{"hash":"43087234100154669","title":"Mitochondrial Transporters and Metabolic Regulation","description":"The terms cluster around mitochondrial processes: transmembrane transport of ADP, NAD, phosphate, alpha-ketoglutarate, ornithine; heme transport; mitochondrial ROS response and apoptotic changes; and adaptive thermogenesis. Together they indicate a module centered on mitochondrial metabolite exchange and energy metabolism, with insulin secretion modulation linked to mitochondrial energy status in beta cells.","confidence":"High","size":12,"edges":16,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":7},{"id":"GO:0015742","count":6},{"id":"GO:1990845","count":6},{"id":"GO:0015886","count":6},{"id":"GO:0000303","count":6}]},{"hash":"805228455016132559","title":"Developmental Chromatin Regulation of Transcription","description":"The cluster centers on transcriptional control and chromatin state, including negative regulation of RNA Pol II transcription and regulation of rDNA transcription by RNA Pol I, plus heterochromatin formation and histone methylation notes. The presence of processes tied to development (brain development, muscle differentiation, spermatogenesis, pro-B cell differentiation) suggests these proteins coordinate chromatin-mediated transcriptional programs during development, with supporting roles in RNA decay and nuclear RNA quality control that link transcription to RNA turnover in the nucleus.","confidence":"High","size":12,"edges":53,"triangles":113,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0034184","count":8},{"id":"GO:1901837","count":8},{"id":"GO:0070481","count":8},{"id":"GO:0042692","count":8}]},{"hash":"1804587865814376576","title":"ESCRT-dependent vesicle trafficking and viral budding","description":"The top GO terms cluster around ESCRT-mediated processes: multivesicular body assembly, viral budding via host ESCRT, and ubiquitin-dependent degradation via the MVB pathway, suggesting a function in vesicle trafficking and virus-host interactions. Other terms like oxidative stress response and mitochondrial intermembrane space import appear less central to this core theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904669","count":1},{"id":"GO:1903774","count":1},{"id":"GO:0036258","count":1},{"id":"GO:1902188","count":1},{"id":"GO:0039702","count":1}]},{"hash":"1296066584924513437","title":"Calcium-Driven Cardiac and Synaptic Signaling","description":"This cluster centers on proteins involved in calcium regulation and signaling that couple electrical activity to muscle contraction in the heart and to neurotransmission at synapses. The presence of terms related to cytosolic calcium concentration, atrial action potential depolarization, myofibril assembly, actin crosslinking, and synaptic vesicle endocytosis points to a theme of calcium-dependent excitation-contraction coupling in cardiac tissue and calcium-dependent synaptic processes, with supporting cytoskeletal and trafficking roles. Some peripheral terms (like ossification or vacuole fusion) may reflect broader trafficking or structural links but do not override the core calcium- and signaling-centric theme.","confidence":"Medium","size":11,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042144","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0031284","count":1},{"id":"GO:0098912","count":1},{"id":"GO:0055003","count":1}]},{"hash":"2125095860844543289","title":"Neural and Organ Development with Vesicle Trafficking","description":"These GO terms cluster around developmental and organogenesis processes, especially neural development (nervous system and brain development) and organ formation (kidney, spermatid development) with general growth and proliferation. The presence of endocytosis and ER-to-Golgi vesicle transport, plus Roundabout signaling, suggests coordinated cellular trafficking and signaling during tissue formation. Overall, the cluster fits as neural/organ development involving vesicle trafficking.","confidence":"Medium","size":11,"edges":49,"triangles":116,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0007286","count":5}]},{"hash":"1151819737454363519","title":"Neural development and vesicle trafficking","description":"This cluster is dominated by terms linked to nervous system development and synaptic function (brain development; GABAergic synaptic transmission) as well as intracellular transport and secretory pathways (ER-to-Golgi transport; COPII vesicle budding) and cytoskeletal movement, suggesting a theme around neuronal growth and protein trafficking. Some terms related to cell division and ribosome biogenesis appear, but the strongest cohesive signal is neural development coupled with vesicle trafficking.","confidence":"Medium","size":11,"edges":24,"triangles":28,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0051932","count":3},{"id":"GO:0042254","count":2}]},{"hash":"964033974476516434","title":"Unknown","description":"The top terms span saliva secretion, pain perception, thermogenesis, membrane potential regulation, temperature response, potassium transport, heart rate regulation, neutrophil chemotaxis, and Wnt signaling, with no clear single function tying all proteins together. Some terms hint at ion transport and exocrine secretion, but others involve immunity or development, making a cohesive, specific label unreliable. Therefore Unknown.","confidence":"","size":11,"edges":29,"triangles":30,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":5},{"id":"GO:0019233","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0042391","count":4},{"id":"GO:0071502","count":4}]},{"hash":"221408150661527582","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0006406","count":4},{"id":"GO:0071051","count":4},{"id":"GO:0006260","count":4}]},{"hash":"1587746432312942134","title":"Wnt-regulated neural and organ morphogenesis","description":"This cluster centers on developmental processes and signaling regulation, with GO terms for multicellular development, neural differentiation (retrotrapezoid nucleus neuron differentiation; globus pallidus development), sensory system development, and organ morphogenesis (lung epithelium tube branching; uterus development). It also covers transcriptional regulation and Wnt signaling. An outlier term related to immunoglobulin production is present, but the dominant theme is Wnt-regulated development and morphogenesis across neural and organ contexts.","confidence":"Medium","size":11,"edges":13,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0030111","count":5},{"id":"GO:0061452","count":5},{"id":"GO:0048880","count":5}]},{"hash":"1705332469852681717","title":"Organelle trafficking and protein maturation","description":"Multiple top GO terms point to intracellular transport and protein handling: ER-to-Golgi vesicle transport, mitochondrial intermembrane space import, chaperone-mediated protein complex assembly, and late endosomal microautophagy. These centered terms suggest the cluster gathers proteins involved in moving and properly folding/assembling proteins within organelles. Nuclear processes like DNA replication and transcription are present but less aligned with the trafficking/maturation theme, making the overall signal mixed but still dominated by organelle logistics.","confidence":"Medium","size":11,"edges":19,"triangles":13,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:1904874","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0051131","count":3},{"id":"GO:0045041","count":3}]},{"hash":"1852797163644927916","title":"Golgi vesicle trafficking","description":"The GO terms are dominated by Golgi-related processes (Golgi vesicle docking, Golgi organization, inter-Golgi and ER-to-Golgi transport) and SNARE complex assembly, plus general intracellular protein transport. This strongly suggests a shared role in vesicle trafficking through the Golgi.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":2},{"id":"GO:0015991","count":2},{"id":"GO:0035493","count":1},{"id":"GO:0045056","count":1},{"id":"GO:0048211","count":1}]},{"hash":"506633817909006252","title":"Cholesterol Transport and Homeostasis","description":"Most frequent terms in the cluster relate to cholesterol metabolism and trafficking: intestinal cholesterol absorption, cholesterol homeostasis, cholesterol efflux, and cellular response to cholesterol. Although a few terms touch on neural development (thalamus development, spinal cord motor neuron differentiation) and other metabolic processes, the cholesterol-related GO terms predominate, suggesting the proteins function together in cholesterol transport and regulation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030299","count":2},{"id":"GO:0021794","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0033344","count":2},{"id":"GO:0015734","count":2}]},{"hash":"8669113914750389","title":"Mitochondrial biogenesis and proteostasis","description":"Proteins in this cluster are enriched for mitochondrial-related processes: insertion into the inner mitochondrial membrane, oxidative phosphorylation, protein unfolding and the cellular response to misfolded proteins, and protein oligomerization, which collectively point to mitochondrial protein import, folding, and energy metabolism. While there are some nuclear processes (DNA-templated transcription, mRNA export) present, the strongest coherent signal is mitochondrial biogenesis and proteostasis, with some cross-talk to broader cellular regulation. ","confidence":"Medium","size":11,"edges":40,"triangles":65,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0032979","count":4},{"id":"GO:0018279","count":4},{"id":"GO:1903007","count":4}]},{"hash":"436075452400988961","title":"Immune Activation and Oxidative Stress Response","description":"This cluster shows immune-related processes (IL-1\u03b2 production; dendritic cell antigen processing/presentation) alongside oxidative stress and redox-related terms (removal of superoxide radicals, selenium ion response, pH response). The co-occurrence suggests the proteins may coordinate immune signaling with cellular redox balance, rather than a single, narrow function.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001302","count":1},{"id":"GO:0003069","count":1},{"id":"GO:0048773","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0010447","count":1}]},{"hash":"2084287503561859070","title":"Spliceosome and mRNA processing factors","description":"Given the top GO terms, the cluster centers on RNA processing activities, including mRNA splicing via the spliceosome (cis and alternative), mRNA export, and regulation of mRNA stability in response to stress, with additional hints of small-subunit processome assembly. This points to a cohesive group of proteins involved in RNA maturation and processing rather than other pathways. Therefore, the label Spliceosome and mRNA processing factors is appropriate.","confidence":"High","size":10,"edges":39,"triangles":80,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":8},{"id":"GO:0010610","count":8},{"id":"GO:1903586","count":7},{"id":"GO:0000381","count":7},{"id":"GO:0006406","count":7}]},{"hash":"1282549286859696199","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0090084","count":2},{"id":"GO:0046825","count":2},{"id":"GO:1901621","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0006260","count":2}]},{"hash":"2122775074041484049","title":"Broad-substrate transmembrane transport","description":"The cluster is characterized by GO terms pointing to transport across membranes for multiple substrates (xenobiotics, vitamins, sugars, carbohydrates, ions) and related responses. This indicates a general membrane transport function rather than a single substrate-specific role.","confidence":"High","size":10,"edges":18,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":8},{"id":"GO:0035461","count":8},{"id":"GO:0042891","count":5},{"id":"GO:0042908","count":5},{"id":"GO:0071805","count":5}]},{"hash":"1718804148461996357","title":"Developmental signaling and trafficking","description":"The GO terms cluster around development and differentiation (negative regulation of EMT, lung epithelial differentiation, muscle fiber-type switching) plus membrane trafficking (ER-to-Golgi transport) and signaling (postsynaptic calcium regulation), with supporting references to lipid metabolism and broad cellular processes. While some terms reflect general cellular functions (DNA replication, miRNA processing), the strongest signals point to developmental signaling and cargo transport as a coherent theme. ","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0010719","count":10},{"id":"GO:1900486","count":10},{"id":"GO:0006260","count":10},{"id":"GO:1903799","count":10},{"id":"GO:0014883","count":10}]},{"hash":"247719221995956359","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms for translation (cytosolic and mitochondrial) and ribosome biogenesis/assembly (cytosolic large subunit assembly, mitochondrial translation), pointing to components of the ribosome and protein-synthesis machinery across compartments. A few non-core terms (nerve growth factor response, ion transport) appear as minor associations but do not drive the main theme.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0002181","count":3},{"id":"GO:0042256","count":2},{"id":"GO:0042273","count":2},{"id":"GO:1990090","count":2}]},{"hash":"2032955675612708632","title":"Muscle adaptation and nucleolar transcription regulation","description":"This cluster centers on skeletal muscle development and denervation-associated muscle adaptation, suggesting roles in muscle growth and response to neural cues. The presence of terms related to androgen receptor signaling and osteoblast differentiation hints at hormonal and bone\u2013muscle cross-talk influencing muscle. Additionally, nucleolar/transcriptional regulation (RNA Pol I, rDNA repeats, heterochromatin) and mitophagy imply coordination of ribosome biogenesis, gene expression, and mitochondrial quality control in muscle cells. Together, these terms point to a module of muscle-specific adaptation coupled with nucleolar transcriptional control and metabolic regulation.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":10},{"id":"GO:0045668","count":10},{"id":"GO:0034503","count":5},{"id":"GO:0031647","count":5},{"id":"GO:0061734","count":5}]},{"hash":"582532486938994481","title":"Spliceosome and RNA processing machinery","description":"The top GO terms cluster around RNA metabolism: spliceosome-mediated mRNA splicing (including alternative splicing), mRNA export, cis-splicing, and small-subunit processome assembly, plus ncRNA-mediated gene silencing and translation reinitiation. This coherence indicates a group of RNA processing/splicing factors, with developmental terms likely reflecting broader post-transcriptional regulation in development.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1903586","count":9},{"id":"GO:0000381","count":9},{"id":"GO:0006406","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0034462","count":9}]},{"hash":"820559037909839857","title":"Unknown","description":"The GO terms span ribosome biogenesis and rRNA maturation, various methylation processes, GTPase regulation, mitotic chromosome segregation, and developmental events (neural tube closure, retina development, single fertilization). This dispersion suggests no single cohesive function or pathway dominates the cluster, making a specific label unlikely.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0001843","count":3},{"id":"GO:2001162","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0051568","count":2}]},{"hash":"775409482810040007","title":"Mitotic Control and Genome Maintenance","description":"The cluster shows strong representation of mitosis-related terms (G2/M transition, chromosome segregation, exit from mitosis) and ubiquitin-proteasome\u2013dependent protein turnover (SCF-dependent proteasomal ubiquitin-dependent catabolic process), along with genome maintenance via nucleotide-excision repair. Additional terms touch on chromatin regulation and transport, but the dominant theme ties cell-cycle control to genome integrity and protein turnover.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0016032","count":10},{"id":"GO:0010458","count":10},{"id":"GO:0007059","count":10},{"id":"GO:0031146","count":10},{"id":"GO:0070911","count":10}]},{"hash":"1280213330378868641","title":"Translation and Ribosome Biogenesis","description":"Dominant signals are translation and ribosome biogenesis (cytoplasmic translation, ribosome biogenesis, translational initiation), suggesting a cluster of proteins involved in protein synthesis and ribosome assembly; other terms like cell cycle/division may reflect coordinated growth but are secondary.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0006413","count":3},{"id":"GO:0042274","count":3},{"id":"GO:0090529","count":3}]},{"hash":"2183001190521534930","title":"Unknown","description":"The GO terms span diverse, unrelated biosynthetic and regulatory processes (e.g., sugar metabolism, sterol metabolism, antibiotic biosynthesis, and transcription regulation) plus an odd development term for labyrinthine layer blood vessels. This breadth suggests no single cohesive function tying the cluster together. Therefore, an Unknown label is most appropriate.","confidence":"","size":10,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019305","count":1},{"id":"GO:0060716","count":1},{"id":"GO:0033320","count":1},{"id":"GO:0008204","count":1},{"id":"GO:0006355","count":1}]},{"hash":"214901560205912737","title":"Unknown","description":"The GO terms span diverse processes including development (gonad, palate, cartilage), immune/complement activation, endocytosis, lipoprotein clearance, transcriptional regulation, integrin signaling, and protein oxidation, with no single unifying function or pathway across the cluster. This lack of a cohesive theme makes a precise, specific name inappropriate, so the label remains Unknown with no confidence.","confidence":"","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":4},{"id":"GO:0008584","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0018057","count":3}]},{"hash":"236966408296002169","title":"Unknown","description":"The top GO terms include inflammatory regulation, apoptotic signaling without ligand, EMT regulation, mevalonate/isoprenoid biosynthesis, DNA replication, miRNA processing inhibition, fiber type transition, lung epithelial differentiation, ER-Golgi vesicle transport, and locomotion. They cover very diverse cellular processes with no clear shared function, and the lack of connections suggests no cohesive theme to name. ","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050728","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0010719","count":1},{"id":"GO:1900486","count":1},{"id":"GO:0006260","count":1}]},{"hash":"967676004468311271","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":12,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006356","count":2},{"id":"GO:0000494","count":2},{"id":"GO:0008033","count":2},{"id":"GO:1990258","count":2},{"id":"GO:0048254","count":2}]},{"hash":"1458048788242610026","title":"Zinc Homeostasis and Transport","description":"The cluster is characterized by GO terms related to zinc ion homeostasis, zinc import/transport across membranes, and detoxification, indicating a cohesive function in zinc handling; a couple of outliers (limb development, pregnancy) appear incidental.","confidence":"High","size":10,"edges":39,"triangles":77,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007565","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0006882","count":1},{"id":"GO:0006831","count":1},{"id":"GO:0070574","count":1}]},{"hash":"160992795061266385","title":"Neurodevelopment with Metabolic Pathways","description":"This cluster is dominated by neural development terms (in utero embryonic development, cerebral cortex development, and positive regulation of neuron projection development), indicating a core theme of neural growth and differentiation. The presence of metabolic processes (TCA cycle, glycerol catabolic process, tetrahydrofolate metabolism) and signaling/response terms (response to xenobiotic, aluminum ion, cellular response to cAMP) suggests concurrent metabolic and signaling activity that often accompanies neural development. Overall, the most representative theme is neural development with supporting metabolic pathways.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0021987","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0019563","count":1},{"id":"GO:0042493","count":1}]},{"hash":"1865441892444980883","title":"Kinase-regulated development and immune signaling","description":"The top GO terms point to regulation of kinase activity and signaling cascades (ERK1/ERK2, ROBO), connected to processes in development (kidney development, ossification, wound healing) and immune-related signaling (T cell receptor signaling, mast cell chemotaxis). Together these imply a cluster of proteins coordinating kinase-driven signaling across development, tissue remodeling, and immune cell migration.","confidence":"High","size":9,"edges":33,"triangles":64,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0045859","count":4},{"id":"GO:0090051","count":4},{"id":"GO:0001822","count":4}]},{"hash":"1534096458266572638","title":"Cytoskeleton dynamics and cell polarity","description":"The top GO terms cluster around cytoskeletal organization and localization: centrosome localization, microtubule localization, meiotic spindle localization, ER polarization, actin cytoskeleton reorganization, and myofibril assembly. These processes reflect cytoskeleton-driven establishment of polarity and structure across development and differentiation, with supporting examples like polar body extrusion and ureteric bud invasion. A neural term (long-term synaptic depression) can still be linked to cytoskeletal remodeling at synapses, reinforcing the theme of cytoskeletal dynamics underpinning diverse cellular functions.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":3},{"id":"GO:0051660","count":3},{"id":"GO:0055003","count":2},{"id":"GO:0010467","count":2},{"id":"GO:0051295","count":2}]},{"hash":"1907886097160857643","title":"RNA Decay and Translation Regulation","description":"The GO terms cluster around mRNA turnover (deadenylation-dependent decay) and core translation processes (cytoplasmic translation, elongation, termination) and ribosome export, suggesting a cohesive role in RNA metabolism and protein synthesis control. Some cell cycle/division terms and antibiotic response appear but are less dominant, so the main theme is RNA processing and translation regulation.","confidence":"Medium","size":9,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0000288","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0000055","count":2}]},{"hash":"220138528159884416","title":"ER-Golgi Trafficking and Secretory Pathway","description":"Most top GO terms describe steps in the secretory pathway and ER-Golgi transport (regulation of ER exit, ER-to-Golgi transport, COPI coating, Golgi ribbon formation, Wnt secretion, and ER lumen protein retention). A few terms involve reproductive or behavioral contexts, but the dominant signal is ER-Golgi trafficking and protein secretion.","confidence":"High","size":9,"edges":12,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048042","count":2},{"id":"GO:0070863","count":2},{"id":"GO:0090161","count":2},{"id":"GO:0002121","count":2},{"id":"GO:1902003","count":2}]},{"hash":"958619367599889001","title":"DNA Damage Response & Cell Cycle Regulation","description":"The cluster's top GO terms cluster around DNA damage response and cell cycle control\u2014meiotic DSB processing, spindle assembly checkpoint\u2013related regulation, camptothecin response, and regulation of nuclear import\u2014together with ubiquitin-proteasome\u2013mediated protein turnover, pointing to coordinated DNA damage signaling and cell-cycle regulation. Some terms about metabolism or development (glucose metabolism, axonogenesis, neuron maturation, cytokine regulation, endothelial chemotaxis) may reflect broader cellular regulation or annotations, but the dominant theme centers on DDR and cell-cycle control.","confidence":"Medium","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006006","count":9},{"id":"GO:0000706","count":9},{"id":"GO:0033160","count":9},{"id":"GO:0032436","count":9},{"id":"GO:1900015","count":9}]},{"hash":"1675518686507135578","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000466","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0000472","count":4},{"id":"GO:0000463","count":4}]},{"hash":"1536507060367679939","title":"Redox Signaling in Spermatogenesis","description":"This cluster centers on oxidative stress and redox processes (peptidyl-cysteine oxidation, hydrogen peroxide catabolic and superoxide removal) along with signaling regulation (MAPK cascade, I-kappaB phosphorylation, non-canonical NF-kappaB signaling) and male gonad development. The combination suggests redox-regulated signaling pathways important for spermatogenesis, with a few metabolic terms likely incidental noise.","confidence":"Medium","size":9,"edges":24,"triangles":31,"max_degree":7,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0018171","count":4},{"id":"GO:0042744","count":4},{"id":"GO:0007283","count":4},{"id":"GO:0032872","count":4},{"id":"GO:0042345","count":4}]},{"hash":"1766378178886853340","title":"Calcium/cAMP Signaling in Development","description":"The top GO terms point to signaling pathways, notably activation of adenylate cyclase (cAMP) and release of sequestered calcium ions, with protein phosphorylation as a downstream process. Developmental terms (heart development, angiogenesis, budding growth) alongside neural-related terms (visual perception, response to amphetamine) suggest these proteins participate in conserved signaling networks that regulate growth and tissue-specific responses. The connection is present but somewhat broad, so a moderate confidence is appropriate.","confidence":"Medium","size":9,"edges":8,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0007118","count":2},{"id":"GO:0043065","count":2}]},{"hash":"1823378053810510413","title":"Bacterial LPS and cell wall glycan biosynthesis","description":"The top GO terms cluster around lipopolysaccharide and O-antigen biosynthesis, plus related cell wall glycan assembly and UDP-N-acetylglucosamine\u2013related biosynthesis, indicating enzymes involved in building bacterial outer-m membrane glycans and envelope structures. Some sugar catabolism terms are present but do not overwhelm the core envelope-glycan theme. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:0005978","count":2},{"id":"GO:0009243","count":2},{"id":"GO:0046115","count":2},{"id":"GO:0071555","count":2}]},{"hash":"531240655493607439","title":"Neural development and signaling","description":"Top terms mainly describe neural development and brain signaling (cerebral cortex development, dendritic spine morphogenesis, behavioral response to cocaine, multicellular organism development). Additional terms cover apoptosis regulation, lipid and immune signaling, and angiogenesis, suggesting broader developmental signaling roles but no single cohesive pathway. I name this cluster Neural development and signaling with Medium confidence.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0060997","count":3},{"id":"GO:0048148","count":3},{"id":"GO:0043065","count":2},{"id":"GO:0001402","count":2}]},{"hash":"1326961157815544268","title":"Metabolism and Hormone Biosynthesis","description":"This cluster centers on diverse biosynthetic processes: retinol/retinal metabolism, fructose and sorbitol biosynthesis, glutathione biosynthesis, and testosterone biosynthesis, with accompanying calcium-responsive signaling and tissue homeostasis. The unifying theme is broad metabolic biosynthesis linked to hormone production and tissue maintenance, rather than a single specific pathway.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":6},{"id":"GO:0042574","count":5},{"id":"GO:0046370","count":5},{"id":"GO:0071277","count":4},{"id":"GO:0006061","count":4}]},{"hash":"1133609268887389942","title":"One-carbon metabolism and nucleotide biosynthesis","description":"The top GO terms cluster around serine metabolism (biosynthesis and catabolism), tetrahydrofolate interconversion, folate metabolism, methylation, and de novo synthesis of purines and dTMP, which together define one-carbon metabolism feeding nucleotide biosynthesis and methylation reactions. A few terms (interferon response, protein tetramerization) appear peripheral to this core theme, but do not negate the central connection.","confidence":"High","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006564","count":3},{"id":"GO:0006565","count":3},{"id":"GO:0035999","count":2},{"id":"GO:0032259","count":2},{"id":"GO:0051289","count":2}]},{"hash":"637894813046726923","title":"NF-kappaB-Driven Immune and Stress Responses","description":"Top GO terms cluster around non-canonical NF-kappaB signaling, TNF signaling, and inflammatory regulation, with involvement of ubiquitin-protein ligase activity and APC-dependent proteolysis, suggesting immune signaling linked to cell-cycle control. Additional terms for metal and salt stress, viral processes, and endopeptidase regulation reinforce a theme of stress-responsive, ubiquitin-regulated signaling. Overall, the cluster appears to reflect NF-kappaB\u2013related immune and stress response functions.","confidence":"Medium","size":9,"edges":16,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0038061","count":3},{"id":"GO:0051437","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0010043","count":2}]},{"hash":"576197721513134062","title":"EGFR Signaling and Membrane Trafficking in Reproductive Epithelium","description":"Contains terms centered on EGFR signaling, membrane trafficking (caveolin-mediated endocytosis, transcytosis), and cell adhesion, with reproductive development terms suggesting roles in reproductive epithelia. This points to a cohesive theme of EGFR-driven signaling linked to membrane trafficking in reproductive tissues.","confidence":"Medium","size":9,"edges":13,"triangles":6,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":7},{"id":"GO:0032436","count":6},{"id":"GO:0007173","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0016337","count":6}]},{"hash":"3450126042520531","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0006284","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0000289","count":2},{"id":"GO:0002107","count":2}]},{"hash":"1154681658948628473","title":"Nervous system development and paranodal axon organization","description":"The terms cluster around nervous system development (central and peripheral), neuron migration, and axon-domain localization at paranodes/juxtaparanodes, including paranodal junction assembly and transmission of nerve impulses, with some associated locomotor behavior terms. This suggests a cohesive group of proteins involved in nervous system development and the specialized paranodal/juxtaparanodal axon regions. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007422","count":1},{"id":"GO:0035640","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0019226","count":1},{"id":"GO:0007417","count":1}]},{"hash":"1046010438985591222","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0051096","count":2}]},{"hash":"948699185542238852","title":"EGFR Signaling and Endocytic Trafficking","description":"Reasoning: the top terms cluster around receptor-level signaling (EGFR pathway) and membrane trafficking processes (caveolin-mediated endocytosis, transcytosis), with several terms related to cell adhesion and protein turnover, suggesting a functional module of proteins involved in surface signaling and endocytic trafficking. Some terms (uterus development, multicellular reproductive process) imply developmental context rather than core function.","confidence":"Medium","size":8,"edges":15,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":7},{"id":"GO:0032436","count":6},{"id":"GO:0007173","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0016337","count":6}]},{"hash":"328431534193875070","title":"Ribosome biogenesis and translation initiation","description":"These proteins are enriched for ribosome biogenesis and translation-related processes, including ribosome biogenesis (GO:0042254), small subunit biogenesis (GO:0042274), formation of translation preinitiation complex (GO:0001731), and translation reinitiation (GO:0002188). While a few terms touch other cellular processes (brain development, vesicle transport, hypoxia response), the dominant signal is assembly of ribosomal components and initiation/continuation of translation, suggesting the cluster represents ribosome-assembly/translation machinery components.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0000747","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0007420","count":3}]},{"hash":"1606365615821950100","title":"RNA processing and translation initiation","description":"The terms cluster around RNA metabolism\u2014splicing via spliceosome, mRNA export, and small-subunit processome assembly\u2014along with translation initiation/reinitiation, suggesting a group involved in RNA processing and ribosome biogenesis rather than a single signaling pathway.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:1903586","count":3},{"id":"GO:0000381","count":3},{"id":"GO:0006406","count":3}]},{"hash":"1032180123398291847","title":"DNA Damage Repair and Genome Maintenance","description":"This cluster shows proteins associated with multiple DNA repair pathways (base excision repair, nucleotide excision repair, translesion synthesis, SSA) plus DNA replication and regulation of apoptosis, all pointing to maintenance of genome integrity. The presence of protein oligomerization hints at repair complex assembly, reinforcing a cohesive theme around DNA damage response and genome maintenance.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0070987","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0045008","count":3}]},{"hash":"605281071148509897","title":"Neuronal axon guidance and synapse development","description":"Top terms emphasize neural connectivity: axon guidance, axon extension, synapse organization, and pyramidal neuron differentiation, with regulation of Rho signaling related to growth cone dynamics. While there is a transcription-related cluster hint, the dominant signal is the program of neuronal development guiding axons to form synapses. Overall, the proteins appear involved in shaping neuronal connectivity, particularly in pyramidal neurons.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0048675","count":2},{"id":"GO:0035418","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0050808","count":2}]},{"hash":"2001270389452714882","title":"Gametogenesis and Gonadal Development","description":"Top GO terms are dominated by reproductive development: male gonad development, oocyte maturation, and male meiosis I, which point to gametogenesis. There are additional development-focused terms such as skeletal muscle tissue development and regulation of transcription, suggesting broader developmental regulation but with a principal emphasis on germ cell/gonadal processes. Some terms (protein homooligomerization, xenobiotic response, t-circle formation) appear less central to this theme, but do not override the core signal of gametogenic/gonadal development.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0042493","count":1},{"id":"GO:0001556","count":1}]},{"hash":"941016471799718061","title":"Mitochondrial electron transport and inner membrane biogenesis","description":"The cluster is dominated by mitochondrial-related GO terms: apoptotic process, mitochondrial respiratory chain complex IV assembly, proton transmembrane transport, and protein insertion into the mitochondrial inner membrane, pointing to energy metabolism and inner membrane biogenesis. Some terms refer to broader membrane lipid biosynthesis or obsolete annotations, but the core signal remains mitochondrial respiration and membrane assembly. ","confidence":"High","size":8,"edges":14,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0033617","count":2},{"id":"GO:0042774","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0006626","count":2}]},{"hash":"1430819381742261654","title":"Neural Development and Synaptic Regulation","description":"The cluster includes GO terms focused on nervous system development, neuronal stem cell maintenance, and glial differentiation, along with synaptic functions such as GABAergic transmission and PSD-95 clustering, indicating roles in both neural development and synaptic organization. Although a term about inner ear stereocilia touches on sensory structures, the dominant theme ties to neural differentiation and synaptic signaling, supporting a cohesive label. ","confidence":"High","size":8,"edges":15,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0060122","count":1},{"id":"GO:0090675","count":1},{"id":"GO:0072307","count":1},{"id":"GO:1902897","count":1}]},{"hash":"1859150876486709741","title":"Mitochondrial Translation and Ribosome Biogenesis","description":"The enriched terms cluster around mitochondria (membrane fission and genome maintenance) and core translation machinery (cytoplasmic translation, ribosomal subunit biogenesis, tRNA modification), with some cell-division related terms that can reflect mitochondrial fission/division, suggesting the proteins participate in mitochondrial protein synthesis and division-related processes.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":3},{"id":"GO:0090149","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0042274","count":2}]},{"hash":"1546769796187456703","title":"Chromatin Organization and Nucleosome Assembly","description":"Top GO terms point to chromatin-related processes (nucleosome assembly, heterochromatin organization, and chromatin localization), with a few translation-related terms likely noise. This suggests the cluster is enriched for proteins involved in chromatin structure and histone-associated regulation rather than cytosolic processes.","confidence":"Medium","size":8,"edges":14,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098532","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0070828","count":2},{"id":"GO:0071169","count":2}]},{"hash":"665754615697925137","title":"Mitochondrial gene expression and mtDNA metabolism","description":"This cluster is dominated by mitochondrial-related terms: translation and mitochondrial tRNA aminoacylation, along with mtDNA metabolic processes and the respiratory chain, indicating a focus on mitochondrion-based gene expression and energy production rather than cytosolic functions.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0022904","count":1},{"id":"GO:0071897","count":1},{"id":"GO:0015966","count":1},{"id":"GO:0016260","count":1}]},{"hash":"414044928182405300","title":"Proteasome-Mediated Degradation and ER-Associated Quality Control","description":"This cluster is dominated by GO terms linked to ubiquitin-proteasome\u2013dependent protein catabolism (including SCF-mediated ubiquitination) and ER-associated degradation (ERAD), as well as related nuclear proteostasis activities. While a few terms touch chromatin organization or synapse assembly as outliers, the strongest shared function is protein degradation and quality control via the proteasome and ERAD pathways.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0061186","count":7},{"id":"GO:0090089","count":7},{"id":"GO:1904153","count":7},{"id":"GO:0043951","count":7}]},{"hash":"1457986321697606778","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090084","count":2},{"id":"GO:0046825","count":2},{"id":"GO:1901621","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0006260","count":2}]},{"hash":"616579219215882335","title":"Solute transport across membranes","description":"Based on the GO terms, this cluster centers on transport of small solutes across the plasma membrane. Notable entries include L-arginine import and catabolic processes, GABA transport, polyamine transmembrane transport, and carnitine transmembrane transport, together with osmotic/volume-regulation terms (cell volume homeostasis, hypotonic salinity response). These point to a shared function in moving amino acids and related metabolites across membranes and contributing to cellular osmoregulation, rather than a single enzymatic activity. Therefore, \"Solute transport across membranes\" is a representative label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042993","count":2},{"id":"GO:0097638","count":1},{"id":"GO:1902269","count":1},{"id":"GO:0071477","count":1},{"id":"GO:0006527","count":1}]},{"hash":"244393876529161812","title":"Cytoskeleton-driven growth and division","description":"The top GO terms cluster around cytoskeletal dynamics and mitotic processes: actomyosin contractile ring assembly (cytokinesis), plus-end-directed vesicle transport along microtubules, centrosome separation, metaphase chromosome alignment, and microtubule depolymerization. Developmental terms like neuron projection maintenance, root development, and ureteric bud invasion suggest morphogenesis driven by cytoskeletal remodeling. Together, these indicate a coherent theme of cytoskeleton-mediated growth, movement, and cell division.","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1990535","count":7},{"id":"GO:0048364","count":7},{"id":"GO:0001560","count":7},{"id":"GO:0007100","count":7},{"id":"GO:0000915","count":7}]},{"hash":"1982775545820654755","title":"Nervous system and inner ear development","description":"The top GO terms cluster around brain and inner ear development, stereocilium organization, postsynaptic density clustering, and apical protein localization, all pointing to neural-sensory differentiation and synaptic organization, especially in inner ear hair cells. Some terms (e.g., marginal zone B cell differentiation, nephron tubule differentiation) may reflect broader multifunctionality or annotation noise, but the core signal supports a neuro-sensory development theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002315","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0048839","count":4},{"id":"GO:0045176","count":4},{"id":"GO:0007626","count":4}]},{"hash":"210977021597827037","title":"Developmental Gene Regulation and Morphogenesis","description":"The GO terms point to transcriptional regulation and signaling control (negative regulation of transcription by RNA Pol II; regulation of gene expression; Wnt signaling), as well as neural development and morphogenesis (neuron differentiation, axon extension, globus pallidus development, sensory system development, lung morphogenesis). Some terms appear incidental (immune and plant-related processes), but together they suggest proteins involved in developmental gene regulation and tissue formation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0030111","count":1},{"id":"GO:0061452","count":1},{"id":"GO:0048675","count":1},{"id":"GO:2000652","count":1}]},{"hash":"1768160543511007309","title":"Neuronal Signaling and Brain Development","description":"The cluster centers on neural processes, with GO terms highlighting ERK1/ERK2 cascade regulation, Rho protein signaling, presynaptic vesicle exocytosis, and brain/nervous system development. While a few terms pertain to broader signaling or non-neural contexts (e.g., T cell receptor signaling), the dominant theme reflects neuronal signaling and brain development.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0007399","count":3}]},{"hash":"2265676251317110094","title":"Unknown","description":"The GO terms are scattered across diverse biological areas (DNA replication, transcription, nuclear transport, histone regulation) and include several seemingly unrelated terms (striatum development, parathyroid hormone response, gibberellin signaling), giving no clear, cohesive theme to bind the cluster. ","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000413","count":2},{"id":"GO:0021756","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0046825","count":2},{"id":"GO:0006260","count":2}]},{"hash":"816518366146212997","title":"RNA splicing and mRNA export","description":"Dominant GO terms center on spliceosome-mediated splicing, mRNA export from the nucleus, and processome assembly, indicating a shared role in post-transcriptional RNA processing; a few terms are outdated or peripheral, but the core signals reflect RNA maturation functions.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903586","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0006406","count":1},{"id":"GO:0045292","count":1},{"id":"GO:0034462","count":1}]},{"hash":"1335750597298731740","title":"Nuclear RNA Splicing and Processing","description":"The top terms are dominated by spliceosome-related processes (spliceosomal complex assembly; mRNA splicing via spliceosome) and other nuclear RNA maturation/ turnover activities (maturation of SSU-rRNA; deadenylation-dependent decapping; import into nucleus; histone mRNA metabolism), indicating a cohesive theme of RNA processing and splicing in the nucleus. Some terms reflect broader chromatin or stress-related processes, but the strongest signal is RNA processing.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000245","count":5},{"id":"GO:0009737","count":4},{"id":"GO:0009414","count":4},{"id":"GO:0070317","count":4},{"id":"GO:1990141","count":4}]},{"hash":"1912485531539618536","title":"Steroid and lipid biosynthesis","description":"Several top GO terms pertain to biosynthetic processes for steroids and lipids, including testosterone biosynthesis, glucocorticoid biosynthesis, androgen catabolic, fatty acid elongation, sphingolipid biosynthesis, and retinol/retinal metabolism, suggesting a focus on lipid and steroid metabolism pathways. A transcription regulation term is present but appears peripheral to the main biosynthetic theme.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":5},{"id":"GO:0061370","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0042574","count":5},{"id":"GO:0006704","count":5}]},{"hash":"398637745523925023","title":"Viral life cycle and host interaction proteins","description":"The GO terms cluster around viral processes (viral life cycle, virion assembly, viral release, symbiont entry into host) and host-cell remodeling (lipid droplet organization, leukocyte migration, protein secretion). The inclusion of protein folding and peptidyl-prolyl isomerization suggests chaperone-like roles aiding viral protein maturation. Overall, this cluster seems to comprise proteins involved in viral infection and manipulation of host cell biology.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000413","count":2},{"id":"GO:0019058","count":2},{"id":"GO:0034389","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0050714","count":2}]},{"hash":"1495693195664455076","title":"Unknown","description":"The terms show innate immune-related processes (innate immune response, regulation of cytokine production) but also include unrelated terms (glucose metabolism, meiotic DNA processing, spindle checkpoint/nuclear import), and there are no connections between proteins (Edges 0, Max Degree 0), so there is no cohesive function to label.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0006006","count":2},{"id":"GO:0000706","count":2}]},{"hash":"1338026783929221515","title":"Sarcomere Assembly and Actin Cytoskeleton Dynamics","description":"The top GO terms cluster around sarcomere organization, skeletal muscle fiber development, and Arp2/3-mediated actin nucleation, indicating a module focused on muscle structure and cytoskeletal dynamics. While there are a few unrelated terms, the dominant signal reflects muscle contractile apparatus assembly and actin organization.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043982","count":6},{"id":"GO:0016344","count":6},{"id":"GO:0048741","count":6},{"id":"GO:0034314","count":6},{"id":"GO:0010628","count":6}]},{"hash":"1540586561406009089","title":"ER-Golgi transport and cell division","description":"Dominant themes are ER-to-Golgi and Golgi-to-ER vesicle transport and its regulation by GTPases, with concurrent signals for cell proliferation (mitotic cell cycle, cell division). Ribosome biogenesis aligns with overall growth, while neuron projection development and pigmentation are less central outliers. The label reflects a core of intracellular trafficking intertwined with division processes.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0000747","count":2}]},{"hash":"1167763687572020086","title":"Amino acid and vitamin biosynthesis","description":"This cluster centers on biosynthetic and metabolic processes, with multiple terms for amino acid metabolism (glutamate, tryptophan, lysine, aspartate, threonine) and vitamin biosynthesis (cobalamin, biotin), plus sphingomyelin biosynthesis. Notch signaling is a single outlier. The shared theme is synthesis-related metabolic pathways, hence the label.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019550","count":1},{"id":"GO:0019441","count":1},{"id":"GO:0009236","count":1},{"id":"GO:0033512","count":1},{"id":"GO:0006532","count":1}]},{"hash":"527148272809237756","title":"Cardiac calcium signaling and electrical conduction","description":"The top GO terms cluster around calcium handling (calcium transport, store-operated calcium channel regulation), regulation of electrical coupling in cardiac conduction, and ventricular muscle morphogenesis, with supporting signals from cAMP/cGMP pathways and regulatory phosphorylation. Together these suggest a group of proteins involved in cardiac excitation-contraction signaling and heart development, rather than general cytoskeletal or metabolic processes.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":4},{"id":"GO:0031284","count":3},{"id":"GO:0007190","count":3},{"id":"GO:0016061","count":3},{"id":"GO:0070588","count":3}]},{"hash":"1698733157600256826","title":"Neural development and synaptic function","description":"The prominent GO terms point to nervous system development and synaptic activity, including GABAergic transmission, PSD-95 clustering, and neuronal stem cell maintenance, plus inner ear receptor cell stereocilium organization. This pattern suggests the proteins are involved in neural development and synaptic/hair-cell signaling rather than a single unrelated process. Some terms (apoptotic process, ossification, nephron differentiation) are ancillary or reflect broader tissue expression.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0007399","count":1},{"id":"GO:0060122","count":1},{"id":"GO:0090675","count":1},{"id":"GO:0072307","count":1}]},{"hash":"1081322529876727038","title":"Embryonic and germline stem cell development","description":"The top GO terms cluster around embryonic development, neuron differentiation, and female germ-line stem cell maintenance, with meiosis I and stem cell differentiation reinforcing a germline/developmental theme. Supporting terms point to chromatin regulation, protein turnover, and DNA repair, which are common during developmental processes. Taken together, this cluster best labels as embryonic and germline stem cell development.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":4},{"id":"GO:0030182","count":3},{"id":"GO:0036099","count":3},{"id":"GO:0090052","count":3},{"id":"GO:0032436","count":3}]},{"hash":"678986358713154382","title":"Neural development and transcription regulation","description":"The strongest signals are neural development-related terms (dendrite morphogenesis and CNS neuron development), suggesting a link to neuronal differentiation. There are also transcription-related terms (DNA-templated transcription) and nuclear processes (protein import regulation, proteasomal degradation, and p53-mediated DNA damage response). Other terms touch on metabolism and spindle checkpoint regulation, but these do not form a tight shared theme. Overall, the cluster seems anchored around neural development with transcriptional control, though the cohesion is moderate.","confidence":"Low","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006977","count":2},{"id":"GO:0048813","count":2},{"id":"GO:0021954","count":2},{"id":"GO:0006006","count":1}]},{"hash":"420605380440663049","title":"Ribosome Biogenesis and rRNA Processing","description":"The dominant GO terms point to ribosome production and RNA processing: translation, ribosome biogenesis, maturation of LSU-rRNA, snoRNP assembly, and snRNA pseudouridine synthesis. These collectively indicate roles in ribosome assembly and RNA modification essential for ribosome maturation. A few other terms (MAPK regulation, fertilization) appear only once and are likely incidental noise. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":2},{"id":"GO:1900745","count":1},{"id":"GO:0007338","count":1},{"id":"GO:1904571","count":1}]},{"hash":"1647065082148705303","title":"Embryonic Development and Organogenesis","description":"These proteins are associated with GO terms spanning development and morphogenesis across multiple organs and systems, including retina, cerebellum, sensory systems, uterus, lung morphogenesis, and brain region development, as well as Wnt signaling regulation affecting gene expression during development. The common thread is broad embryonic development and organ formation rather than a single specific function, so the label Embryonic Development and Organogenesis captures the cluster well.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030111","count":6},{"id":"GO:0061452","count":6},{"id":"GO:0048880","count":6},{"id":"GO:0021759","count":6},{"id":"GO:0023019","count":6}]},{"hash":"1827356770598091604","title":"Potassium Transport and Homeostasis","description":"Most of the top GO terms describe potassium ion import/export across the plasma membrane and intracellular potassium ion homeostasis, plus related proton transport. This points to a coherent theme of membrane-associated potassium balance across cells, despite a few outlier annotations (e.g., pre-B cell differentiation, stilbene catabolic process). The lack of edges does not negate this functional trend, as these proteins can participate in transport or homeostasis without direct interaction in this dataset.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":3},{"id":"GO:1990573","count":3},{"id":"GO:0030007","count":3},{"id":"GO:0097623","count":3},{"id":"GO:0002329","count":2}]},{"hash":"1199150257020265228","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":5},{"id":"GO:0090084","count":4},{"id":"GO:0046825","count":4},{"id":"GO:1901621","count":4},{"id":"GO:0009408","count":4}]},{"hash":"1417569810260507982","title":"Transmembrane transporters for ions and small molecules","description":"The top GO terms indicate broad transmembrane transport activity across diverse substrates\u2014sugars (arabinose, galactose, sialic acid), ions (sodium, potassium, phosphate), nitrate, and xenobiotics\u2014plus a vesicular neurotransmitter loading step. This combination points to a cluster of membrane transporter proteins with broad substrate specificity across ions, sugars, and related compounds.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":3},{"id":"GO:0015751","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0015757","count":3}]},{"hash":"1204559049861416376","title":"Cardiac Electrophysiology and Development","description":"This cluster centers on cardiac physiology: regulation of ventricular and atrial/SA node action potentials, calcium release from the sarcoplasmic reticulum, and heart development/hypertrophy, pointing to a cardiac electrophysiology and development theme. Some terms like ossification and skin development are less central to the core function.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":5},{"id":"GO:0098911","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0003220","count":4},{"id":"GO:0043588","count":4}]},{"hash":"97070973269839798","title":"Bacterial LPS and cell wall biosynthesis","description":"GO terms point to lipopolysaccharide and O-antigen biosynthesis, UDP-N-acetylglucosamine precursor production, and cell wall organization, suggesting proteins involved in assembling the bacterial outer membrane polysaccharide layer. Some DNA repair terms appear but are likely peripheral to the main envelope biosynthesis theme. ","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:0005978","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0006284","count":2},{"id":"GO:0006310","count":2}]},{"hash":"1558680991003242773","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":2},{"id":"GO:0010124","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0006635","count":2},{"id":"GO:0042372","count":2}]},{"hash":"812301839197164914","title":"Chromatin-mediated transcription regulation","description":"The GO terms show DNA-templated transcription and histone H2A K63-linked ubiquitination, indicating a shared focus on gene expression control through chromatin modification, with additional signaling-related terms appearing as secondary. This supports naming the cluster as chromatin regulation and transcription.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001702","count":2},{"id":"GO:0070535","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0046328","count":1},{"id":"GO:0030708","count":1}]},{"hash":"1196467184429211943","title":"Unfolded Protein Response and ER Stress Signaling","description":"The top GO terms cluster around cellular responses to unfolded proteins, ER stress, and regulation of apoptotic pathways, including neuron-specific intrinsic apoptotic signaling. There is also a related term on post-translational targeting to membranes, which fits ER/Golgi-related quality control, while a somewhat unrelated DNA replication term appears among the list. Overall, the dominant theme is protein folding stress response and its link to apoptosis rather than core DNA replication or other processes, justifying a concise ER stress\u2013related label.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0090084","count":4},{"id":"GO:0000902","count":4},{"id":"GO:0034620","count":4},{"id":"GO:1902037","count":4}]},{"hash":"1023067179906011742","title":"Diverse solute transporters","description":"This cluster\u2019s GO terms are centered on transport across membranes for a variety of substrates (glucose, arabinose, sialic acid, trehalose, xenobiotics, organic anions) and related osmotic response, indicating a group of proteins that mediate diverse solute transport rather than a single substrate. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":1},{"id":"GO:0006970","count":1},{"id":"GO:0015739","count":1},{"id":"GO:0015751","count":1},{"id":"GO:0042891","count":1}]},{"hash":"1533809755220041583","title":"Gene expression and genome maintenance","description":"The Top Terms show transcription initiation/elongation by RNA polymerase II, translation, ribosome biogenesis, and DNA replication, along with nucleotide-excision repair and components of protein quality control (aggresome, ubiquitin-dependent ERAD). This mix suggests a cluster centered on core gene expression processes with links to genome maintenance and proteostasis. The label \"Gene expression and genome maintenance\" best captures the dominant pattern across the terms, though some protein quality-control and signaling terms indicate additional connectivity.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006289","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0070842","count":2},{"id":"GO:0007266","count":2}]},{"hash":"1769420390380472589","title":"Proteostasis: ubiquitin-like modification and autophagy","description":"The cluster centers on protein quality control and turnover, with multiple GO terms for post-translational modifications (sumoylation, neddylation, lipidation), degradation pathways (ubiquitin/ERAD), and macroautophagy, together with cell cycle regulation. A few terms (amygdala development, MyD88 signaling) appear less connected but do not obscure the dominant proteostasis theme.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0021764","count":2},{"id":"GO:0044805","count":2},{"id":"GO:0045116","count":2}]},{"hash":"1647817651516306872","title":"Embryonic Development and Morphogenesis","description":"The top terms center on embryonic tissue formation and patterning across diverse organs (cranial skeleton, forebrain, neural crest, pancreas, ureteric branching), with additional enrichment for gene-regulatory processes (chromatin remodeling, transcriptional control, splicing) that are characteristic of developmental programs. This points to a broad developmental/morphogenetic theme rather than a single, specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":2},{"id":"GO:0043044","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0048026","count":2}]},{"hash":"2114520743713987762","title":"Genome maintenance and mitochondrial protein homeostasis","description":"Top GO terms include nuclear genome maintenance (DNA replication and DNA recombination) alongside mitochondrial-related processes (protein insertion into the inner mitochondrial membrane, oxidative phosphorylation, and protein unfolding/misfolded protein response). Additional terms touch on protein folding/oligomerization and mRNA export, suggesting a broad cellular housekeeping module that spans genome integrity and mitochondrial protein handling. The label reflects this combination of nuclear genome maintenance and mitochondrial protein quality control as the cluster\u2019s core theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0032979","count":1},{"id":"GO:0018279","count":1},{"id":"GO:1903007","count":1}]},{"hash":"2289306680381462710","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":2},{"id":"GO:0045071","count":1},{"id":"GO:0031442","count":1},{"id":"GO:0098789","count":1},{"id":"GO:0000184","count":1}]},{"hash":"854615713020517966","title":"Unknown","description":"The GO terms span mitochondrial processes (electron transport, proton transport) alongside viral and host-symbiont interactions, protein oligomerization, lifespan determination, and metabolic processes, with no clear unifying function and no edges linking the proteins. This scattered set provides no coherent theme to assign a specific, concise label. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006627","count":1},{"id":"GO:0016032","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0032461","count":1},{"id":"GO:0008340","count":1}]},{"hash":"679326782293331438","title":"Neuroimmune Inflammation and Synaptic Regulation","description":"The cluster centers on inflammatory/immune processes and regulation of synaptic transmission (GABAergic and glutamatergic), suggesting proteins that bridge immune signaling with neuronal communication.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0051482","count":1},{"id":"GO:0001985","count":1},{"id":"GO:0090023","count":1},{"id":"GO:0061358","count":1}]},{"hash":"257988463653303864","title":"Unknown","description":"The listed GO terms are spread across distinct processes (N-linked glycosylation, neuromast hair cell differentiation, xenobiotic response, cellular response to cAMP, corneocyte development, and apoptosis) with no clear, single shared function or pathway linking the proteins. Because of this lack of a cohesive theme, a precise, representative label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006487","count":1},{"id":"GO:0070658","count":1},{"id":"GO:1903507","count":1},{"id":"GO:0042493","count":1},{"id":"GO:0071320","count":1}]},{"hash":"1844734209796007703","title":"Unknown","description":"The reported GO terms are highly diverse, including protein peptidyl-prolyl isomerase activity, regulation of protein modification, various organ development terms (striatum, intestine left/right, ureter), cell cycle-related catabolic process, LPS metabolism, and plant cytokinin signaling. There is no clear, single functional theme connecting these proteins; they do not share a cohesive pathway or process, so a specific label isn\u2019t apparent.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000413","count":2},{"id":"GO:0031400","count":2},{"id":"GO:0021756","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0071908","count":2}]},{"hash":"418161369248462239","title":"Neuronal synaptic vesicle trafficking and receptor localization","description":"The GO terms point to synaptic vesicle cycling, vesicle fusion, Golgi organization, endosome transport, and postsynaptic receptor insertion, which together describe neuronal synaptic transmission and plasticity processes involving vesicle recycling, trafficking through the secretory pathway, and receptor localization at the synapse.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903422","count":1},{"id":"GO:0090161","count":1},{"id":"GO:0033194","count":1},{"id":"GO:1903358","count":1},{"id":"GO:0060291","count":1}]},{"hash":"2030153920376585356","title":"Lipid remodeling and signaling","description":"This cluster is driven by multiple lipid-related GO terms: ether lipid biosynthesis, phosphatidylcholine acyl-chain remodeling, and cardiolipin remodeling, plus platelet activating factor biosynthesis. While there are immune and developmental terms (IL-2 production, T cell death regulation, cerebellum morphogenesis), these can be linked to lipid-mediated signaling and membrane biology. Overall, the unifying theme appears to be membrane lipid metabolism and lipid-mediated signaling pathways.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010143","count":2},{"id":"GO:0070236","count":2},{"id":"GO:0002071","count":2},{"id":"GO:0006663","count":2},{"id":"GO:0070970","count":2}]},{"hash":"2117147779655239924","title":"Endosome-Lysosome Trafficking and TOR Regulation","description":"The GO terms cluster around endosome to lysosome transport, vacuole fusion, and small GTPase\u2013mediated signaling, with TOR pathway regulation and chloroquine response further tying to lysosomal function and growth control. This suggests a cohesive theme of vesicle trafficking linked to growth signaling, despite some apparently unrelated terms that may reflect annotation noise. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902350","count":1},{"id":"GO:0048814","count":1},{"id":"GO:0097576","count":1},{"id":"GO:0043276","count":1},{"id":"GO:0051056","count":1}]},{"hash":"454275001082743333","title":"Actin-driven endocytosis and transcytosis","description":"The cluster\u2019s shared GO terms predominantly point to actin dynamics (actin filament polymerization, filopodium assembly) and membrane trafficking processes (caveolin-mediated endocytosis, transcytosis, endocytosis regulation), suggesting a functional module focused on cytoskeleton remodeling coupled to vesicular transport and barrier-related functions. Some terms (uterus development, B cell proliferation) are less directly connected, but the core theme centers on actin-associated endocytic and transcytotic activity.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007173","count":3},{"id":"GO:0060065","count":3},{"id":"GO:1900740","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0090557","count":3}]},{"hash":"141635758579640281","title":"Cytoskeleton remodeling and membrane dynamics","description":"The GO terms point to actin dynamics (barbed-end capping), membrane remodeling (ruffle formation, membrane invagination), and regulation of Rho GTPases, plus processes like phagocytic engulfment and development that rely on cytoskeletal changes. While developmental terms appear, the common thread is cytoskeleton-driven membrane remodeling and associated signaling, suggesting a cohesive cluster around cytoskeleton dynamics rather than a single specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034260","count":2},{"id":"GO:0060292","count":1},{"id":"GO:0051016","count":1},{"id":"GO:0010863","count":1},{"id":"GO:1900029","count":1}]},{"hash":"902322170300876645","title":"Unknown","description":"This cluster shows a mix of GO terms spanning development (ossification, brain development), immune/dendritic cell migration, viral processes, and core cellular processes (phosphorylation/dephosphorylation, DNA repair, ribosome biogenesis). The terms do not converge on a single, coherent function or pathway, making it difficult to assign a specific label. ","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0009405","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0016311","count":2}]},{"hash":"363343542338436320","title":"Organogenesis and patterning","description":"This cluster shows a broad mix of GO terms tied to developmental processes across multiple tissues (lens growth, left/right patterning, various gland developments, neuronal differentiation, and cartilage/bone-related growth). The overall pattern points to roles in developmental patterning and organogenesis rather than a single specific function, despite a few outlier terms. Confidence: Medium.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2001111","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0034587","count":1},{"id":"GO:0003415","count":1},{"id":"GO:0070384","count":1}]},{"hash":"1733277135377305543","title":"Nuclear import and transcriptional regulation","description":"This set centers on nuclear processes: import of proteins bearing NLS, localization to the nuclear membrane, mRNA export in response to heat, and regulation of SMAD signaling, all pointing to nuclear transport and transcriptional control, with some associated chromatin/heat shock responses. The presence of a few obsolete GO terms aside, the core theme is nuclear localization and transcriptional regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000061","count":1},{"id":"GO:0007184","count":1},{"id":"GO:0036228","count":1},{"id":"GO:0035080","count":1},{"id":"GO:0006607","count":1}]},{"hash":"1820614707663140587","title":"Translation Initiation and Ribosome Biogenesis","description":"Enriched in translation initiation and reinitiation terms, ribosome biogenesis, and rRNA maturation, suggesting these proteins participate in assembling and initiating protein synthesis; some viral translation terms reflect broader initiation mechanisms.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006446","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0075525","count":2}]},{"hash":"1632374937174442470","title":"Unknown","description":"The listed GO terms are scattered across endocytosis, signaling, differentiation, autophagy, and immune regulation, with no single dominant theme linking all four proteins. Because there is no cohesive function signature, the cluster cannot be given a specific label beyond Unknown.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000413","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0060669","count":2},{"id":"GO:0050847","count":2},{"id":"GO:2000059","count":2}]},{"hash":"449700495856517734","title":"Nuclear RNA Processing and Chromatin Regulation","description":"This cluster is enriched for nuclear RNA processing activities (spliceosomal assembly, mRNA splicing, mRNA decapping) and chromatin-related processes (pericentric heterochromatin formation, histone mRNA metabolism, nuclear import), suggesting a module coordinating transcriptional regulation at both RNA-processing and chromatin levels. The ABA and water-deprivation terms imply stress-related regulation of these nuclear processes, with a possible link to cell-cycle control.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009737","count":2},{"id":"GO:0009414","count":2},{"id":"GO:0070317","count":2},{"id":"GO:1990141","count":2},{"id":"GO:0000290","count":2}]},{"hash":"1361154821350239646","title":"Unknown","description":"The GO terms are highly diverse (kidney development, vision, ascospore formation, guanylate cyclase activity regulation, cardiac muscle assembly, bone ossification, nurse cell\u2013to\u2013oocyte transport, retinal development, apoptosis) with no clear shared function or pathway. Edges are absent, so there\u2019s no cohesive theme to label the cluster meaningfully.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072205","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0030437","count":2},{"id":"GO:0031284","count":1},{"id":"GO:0055003","count":1}]},{"hash":"1871843974285392934","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098504","count":1},{"id":"GO:0016032","count":1},{"id":"GO:1904355","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0006281","count":1}]},{"hash":"1755499446196456036","title":"Mitochondrial Respiration and Mo Cofactor Biosynthesis","description":"The GO terms cluster around mitochondrial energy production and redox biology, including ATP synthesis coupled electron transport, cellular respiration, and regulation of mitochondrial membrane potential, with related terms for ROS metabolism and apoptotic mitochondrial changes. The presence of Mo-molybdopterin cofactor biosynthesis and formate/nitrate metabolism points to molybdenum-dependent enzymes involved in respiration, reinforcing a theme of mitochondrial energy metabolism and associated cofactor biosynthesis. An outlier term for rRNA modification may be incidental. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000154","count":2},{"id":"GO:0009061","count":1},{"id":"GO:0042773","count":1},{"id":"GO:0006777","count":1},{"id":"GO:0045333","count":1}]},{"hash":"1434232453078780016","title":"Symbiont-Host Interaction and Nitrogen Metabolism","description":"The cluster combines GO terms tied to nitrogen fixation and ammonia assimilation (bacterial metabolism) with terms about symbiont surface interactions and evasion of host immune responses, pointing to a theme of bacterial symbiont activity shaping the host environment. Some host-process terms (epithelial proliferation, insulin secretion, glutamatergic transmission) may reflect downstream or annotation spillover from host interactions, but the core signal centers on symbiont metabolism and host modulation during symbiosis.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009399","count":2},{"id":"GO:0044044","count":2},{"id":"GO:0050679","count":2},{"id":"GO:0009749","count":2},{"id":"GO:0009405","count":2}]},{"hash":"1269891719112799643","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0006311","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0070417","count":1},{"id":"GO:0008306","count":1}]},{"hash":"838259144050575865","title":"Unknown","description":"The Top Terms include glucose metabolism, meiotic DNA double-strand break processing, nuclear import regulation, proteasomal ubiquitin-dependent proteolysis, ion homeostasis, cytokine production in inflammation, spindle checkpoint\u2013related nuclear import, axonogenesis regulation, camptothecin response, and sodium transporter activity. This mix spans metabolism, DNA repair/cell cycle, nuclear transport, protein degradation, ion balance, and signaling, with no clear single function or pathway tying the proteins together. The lack of cohesive thematic signal and zero reported edges support assigning an Unknown label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":1},{"id":"GO:0000706","count":1},{"id":"GO:0033160","count":1},{"id":"GO:0032436","count":1},{"id":"GO:2000651","count":1}]},{"hash":"1800481735332451926","title":"Mitotic Regulation via Ubiquitin-Dependent Proteolysis","description":"This cluster centers on cell division and mitosis, highlighted by terms like mitotic cell cycle, cell division, and APC/C-dependent catabolic process. It also heavily features ubiquitin-mediated protein turnover (ubiquitin-dependent proteolysis, K11-linked ubiquitination, ERAD-related pathway), suggesting a cohesive role in controlling protein abundance during mitosis. Some terms point to broader regulatory connections (GTPase signaling, ciliogenesis, brain development) that can intersect with cell cycle programs, but the dominant theme is mitotic control through ubiquitin-driven degradation.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042787","count":3},{"id":"GO:2001162","count":2}]},{"hash":"2129026507851430817","title":"Unknown","description":"The proteins\u2019 GO terms span heat shock and protein refolding, RNA processing and telomere maintenance related to Cajal bodies, and several unrelated processes (sperm binding, immune response to tumor cells, cadmium response). There isn\u2019t a single coherent function or pathway that ties these terms together, so a precise label cannot be assigned.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0042220","count":3},{"id":"GO:0090666","count":3},{"id":"GO:0007339","count":3},{"id":"GO:1904874","count":3}]},{"hash":"694815209458383447","title":"Unknown","description":"The GO terms span diverse processes including glucose metabolism, DNA damage/repair, regulation of nuclear import, proteasomal degradation, inflammatory cytokine regulation, and neuronal/endothelial signaling, with no single cohesive function tying the proteins together. Therefore, a specific cluster name cannot be confidently assigned.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":2},{"id":"GO:0000706","count":2},{"id":"GO:0033160","count":2},{"id":"GO:0032436","count":2},{"id":"GO:1900015","count":2}]},{"hash":"374591942793886345","title":"Nucleolar rDNA transcription regulation","description":"The top GO terms predominantly point to regulation of RNA polymerase I\u2013driven transcription at rDNA repeats and associated chromatin processes (negative regulation of Pol I transcription, rDNA localization, and heterochromatin formation), suggesting a core theme of nucleolar transcription control and chromatin regulation. Other terms in the list (e.g., calcium import, mitophagy, denervation response) appear as peripheral or pleiotropic functions rather than defining the cluster\u2019s main function.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000083","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0098703","count":2},{"id":"GO:0034503","count":1},{"id":"GO:0031647","count":1}]},{"hash":"45728786163302440","title":"Heat- and light-stress response with MAPK signaling","description":"The top GO terms cluster around environmental stress responses, especially to heat and light, including regulation of cellular response to heat and stress-activated MAPK cascade, which points to a coordinated stress-signaling network. Additional terms emphasize control of oxidative stress, amyloid fibril formation, and intracellular transport regulation, supporting a broader protective-response program. A lens morphogenesis term appears as a potential tissue-specific annotation, but the dominant signal is heat/light-induced stress signaling and MAPK-mediated responses.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030308","count":3},{"id":"GO:1900034","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0051403","count":3},{"id":"GO:2000378","count":3}]},{"hash":"545125230638359042","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031442","count":1},{"id":"GO:0098789","count":1},{"id":"GO:0000184","count":1},{"id":"GO:0008315","count":1},{"id":"GO:0006370","count":1}]},{"hash":"1930049356719368676","title":"Cytoskeleton Dynamics and Endocytosis in Development","description":"The cluster centers on actin cytoskeleton polarity (GO:0030950), regulation of receptor-mediated endocytosis (GO:0048260), and PPIase activity (GO:0000413), pointing to roles in cytoskeletal remodeling and membrane trafficking. Additional terms linked to development (lung epithelial differentiation, placental morphogenesis) and signaling (Rho, progesterone receptor) suggest these proteins participate in cytoskeleton-driven processes that coordinate development and signaling; overall, the theme ties cytoskeletal regulation to trafficking and developmental context rather than a single narrow function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000413","count":1},{"id":"GO:0048260","count":1},{"id":"GO:0060669","count":1},{"id":"GO:0035024","count":1},{"id":"GO:0050847","count":1}]},{"hash":"841190915423750062","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031124","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0016584","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1741630778146208198","title":"Nucleotide Biosynthesis and Salvage","description":"Most of the GO terms clustered here point to nucleotide metabolism and salvage (purine ribonucleotide interconversion; CDP biosynthetic process; nucleoside monophosphate phosphorylation; AMP salvage; ADP biosynthetic process; ITP metabolic process). There are also a couple of development terms (brain and liver development), but they appear less representative. The dominant theme is nucleotide biosynthesis and remodeling, suggesting these proteins cooperate in maintaining nucleotide pools and preparing nucleotides for DNA replication. ","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0015951","count":4},{"id":"GO:0046041","count":4},{"id":"GO:0001889","count":4},{"id":"GO:0046705","count":4}]},{"hash":"1986783192093477657","title":"Neuronal axon guidance and synapse formation","description":"This cluster centers on axon development and synapse assembly, including axonogenesis, fasciculation of motor neuron axons, and protein localization at axonal domains, with signaling pathway involvement. A few terms touch broader developmental processes, but the dominant pattern is neuronal axon guidance and synapse formation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097156","count":3},{"id":"GO:2001202","count":3},{"id":"GO:0042698","count":3},{"id":"GO:0050772","count":3},{"id":"GO:0051965","count":3}]},{"hash":"33759442233342501","title":"Gametogenesis and Developmental Morphogenesis","description":"The top GO terms point to germline development (spermatogenesis, spermatid elongation, sperm individualization, oogenesis) and broader developmental morphogenesis (imaginal wing discs), with additional regulatory transcription context. This suggests a cluster of proteins involved in developmental differentiation with a notable emphasis on gamete formation and tissue morphogenesis, hence the label. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:2000582","count":2},{"id":"GO:0022008","count":2},{"id":"GO:0007290","count":2},{"id":"GO:0007476","count":2}]},{"hash":"873536536990350004","title":"Embryonic development and organogenesis","description":"The proteins show GO terms across multiple organ systems (pancreas, digestive tract, heart, neural tube, retina) and developmental signaling (retinoic acid receptor signaling), indicating a broad role in vertebrate embryogenesis and organ formation rather than a single tissue-specific function. CNS-related terms (GABA catabolic process, neural tube development, righting reflex) further support a development-focused theme. Confidence in this broad developmental label is high.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031016","count":3},{"id":"GO:0009258","count":3},{"id":"GO:0009450","count":3},{"id":"GO:0060013","count":3},{"id":"GO:0048566","count":3}]},{"hash":"1422400988478454639","title":"Neural development and synapse assembly","description":"Most of the top GO terms point to neural development and synaptic organization (neuronal stem cell population maintenance, serotonergic neuron axon guidance, and synapse assembly/regulation), with a few terms reflecting broader developmental processes in other tissues (bone formation, nephron differentiation, lung morphogenesis). Thus the cluster appears centered on neural development and synaptic assembly.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0072307","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0097150","count":2},{"id":"GO:0060488","count":2}]},{"hash":"803005606095111562","title":"Germline and reproductive development","description":"The GO terms repeatedly point to germ cell formation and maturation, including spermatogenesis, spermatid nucleus elongation, sperm individualization, and oogenesis, which together suggest a focus on germline development and reproductive processes. While there are also broader developmental terms (neurogenesis, wing morphogenesis), these are less central to the cluster's core pattern. Given the small size and lack of interaction data, the label captures the dominant theme but with moderate confidence. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:2000582","count":2},{"id":"GO:0022008","count":2},{"id":"GO:0007290","count":2},{"id":"GO:0007476","count":2}]},{"hash":"1514542589817053416","title":"Oocyte meiosis and spindle assembly","description":"The key terms point to meiosis in oocytes, with explicit mentions of oocyte maturation and spindle assembly in female meiosis I. While there are a few stress-response and circadian-related terms, the strongest and most coherent signal ties directly to meiosis/oocyte maturation, suggesting a cluster centered on meiotic control in oocytes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001556","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0071406","count":2},{"id":"GO:0070544","count":2},{"id":"GO:0042752","count":2}]},{"hash":"830137693527959322","title":"Regulation of cell proliferation and differentiation","description":"The top GO terms point to developmental processes, with cell proliferation and differentiation as central themes. The inclusion of negative regulation of transcription suggests transcription-level control during development, so the cluster likely represents general developmental regulation rather than a specific pathway; however, the evidence is limited, so the label remains a broad, representative choice.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":1},{"id":"GO:0030154","count":1},{"id":"GO:0045892","count":1}]},{"hash":"268887503999064958","title":"Neural development and axon guidance","description":"The top terms point to neural development (forebrain/midbrain morphogenesis, axon target recognition, pain sensing) and neural identity, with additional signals related to MAPK regulation and inflammatory signaling; a few terms involve ubiquitin-related deubiquitination that can modulate signaling. This suggests a cluster centered on neural development and associated signaling processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071108","count":1},{"id":"GO:0048853","count":1},{"id":"GO:0035522","count":1},{"id":"GO:0043407","count":1},{"id":"GO:1900015","count":1}]},{"hash":"1826983758115997453","title":"LPS and cell wall biosynthesis","description":"The top GO terms cluster around lipopolysaccharide biosynthetic processes (including core region and O antigen) and general cell wall biogenesis/organization, with related glycan biosynthesis terms and even fungal-type cell wall biogenesis. This points to a group of proteins involved in assembling and shaping the cell envelope polysaccharides rather than other metabolic roles.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902758","count":1},{"id":"GO:0019305","count":1},{"id":"GO:0009103","count":1},{"id":"GO:0000902","count":1},{"id":"GO:0009272","count":1}]},{"hash":"1309191015637137904","title":"T cell immune activation and ER protein trafficking","description":"The top GO terms point to T cell\u2013specific immune activities (apoptosis, cytokine production) and innate immune signaling, alongside protein transport and ER retention. Together, they suggest a cluster involved in T cell\u2013driven immune signaling coupled with ER-associated protein processing and trafficking for secreted or membrane proteins.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070231","count":1},{"id":"GO:0006621","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0010204","count":1},{"id":"GO:0002369","count":1}]},{"hash":"2209588479987507603","title":"Embryonic skeletal and neural crest development","description":"The top GO terms are dominated by embryonic skeletal system development, bone and cartilage development, and neural crest cell development, indicating a focus on skeletal/craniofacial lineage formation and neural crest\u2013driven development. Other terms reflect general protein processing and ciliogenesis that can support these developmental processes, while a couple of outliers (pollen tube guidance, obsolete glycosylation) are less central. Overall, the cluster appears to represent skeletal development programs with neural crest involvement.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":1},{"id":"GO:0015693","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0045724","count":1},{"id":"GO:1903012","count":1}]},{"hash":"1282250961499160106","title":"Plant ripening and phenolic biosynthesis","description":"This cluster shows a clear signal for plant development and metabolism, with GO terms for ethylene biosynthesis, fruit ripening, and proanthocyanidin (a phenolic compound) biosynthesis, plus related proline hydroxylation steps typical of plant cell-wall proteins. A minority of terms relate to neuronal processes, which likely reflect annotation noise rather than a core function of the cluster. Overall, the dominant theme is plant maturation and secondary metabolism.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0023041","count":1},{"id":"GO:0007420","count":1},{"id":"GO:0018401","count":1},{"id":"GO:0010023","count":1}]},{"hash":"1410275954811718595","title":"Neuronal apoptotic signaling inhibition","description":"This cluster\u2019s top GO terms repeatedly describe negative regulation of apoptotic pathways (intrinsic and extrinsic), including ER stress\u2013related and Fas signaling, with supporting neuronal context terms like response to glutamate and Purkinje cell differentiation. The shared theme is suppression of cell death signals in neural contexts, implying a pro-survival role for the proteins.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903298","count":1},{"id":"GO:1902236","count":1},{"id":"GO:1902065","count":1},{"id":"GO:1902042","count":1},{"id":"GO:1904721","count":1}]},{"hash":"963023310454009543","title":"Innate Immune Signaling and Antigen Presentation","description":"The top GO terms cluster around immune activation and antigen processing: innate immune response-activating signaling, NF-kappaB signaling, dendritic cell chemotaxis, and peptide antigen assembly with MHC class I. Although there are a few outliers (ER stress, development, vesicle processes), the dominant signal points to immune response and antigen presentation as the core function of this cluster.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030968","count":2},{"id":"GO:2000510","count":1},{"id":"GO:0010204","count":1},{"id":"GO:0090398","count":1},{"id":"GO:0048916","count":1}]},{"hash":"1147862333550022404","title":"Cajal body\u2013associated telomerase regulation","description":"The GO terms strongly cluster around scaRNA localization to the Cajal body, and positive regulation of telomerase RNA localization to the Cajal body, plus positive regulation of telomere maintenance via telomerase, indicating a function centered on Cajal body\u2013driven RNA processing and telomere maintenance. Other terms appear more peripheral, but the core theme is clearly tied to Cajal bodies and telomerase biology.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":3},{"id":"GO:0090666","count":3},{"id":"GO:0007339","count":3},{"id":"GO:1904874","count":3},{"id":"GO:0042026","count":3}]},{"hash":"1059874693937859994","title":"Unknown","description":"The terms span diverse regulatory processes across chromatin regulation, DNA repair, post-translational modification, proteostasis, neuronal signaling, innate immune signaling, nuclear body organization, cytoskeleton, and metabolism. There is no single coherent function or pathway that consistently links these terms, so a robust, intuitive label is not recoverable from the cluster.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":3},{"id":"GO:1904049","count":3},{"id":"GO:0006289","count":3},{"id":"GO:0016925","count":3},{"id":"GO:0032436","count":3}]},{"hash":"452302193783577535","title":"Developmental differentiation and gene regulation","description":"The GO terms span multiple tissue-specific differentiation programs (brain, muscle, keratinocytes, spermatogenesis, pro-B cell differentiation) alongside general regulatory processes (histone methylation, rDNA transcription, mRNA decay, chromatin formation), suggesting a broad theme of development-related gene regulation rather than a single pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034184","count":1},{"id":"GO:1901837","count":1},{"id":"GO:0070481","count":1},{"id":"GO:0042692","count":1},{"id":"GO:0000183","count":1}]},{"hash":"1126311545797507482","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006353","count":2},{"id":"GO:0021756","count":2},{"id":"GO:0006178","count":2},{"id":"GO:0032263","count":2},{"id":"GO:0006223","count":2}]},{"hash":"1507487175150674859","title":"Calcium and potassium ion transport across membranes","description":"The shared GO terms cluster around transmembrane transport of Ca2+, K+ and other cations, including calcium release from Golgi stores, indicating a membrane transport role with emphasis on calcium and potassium ions; some terms about cardiac regulation may reflect downstream effects, while an unrelated stilbene catabolic term is likely incidental in this small cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":1},{"id":"GO:0046272","count":1},{"id":"GO:0099132","count":1},{"id":"GO:0061454","count":1},{"id":"GO:0010107","count":1}]},{"hash":"1547777690273798218","title":"Meiotic DNA Repair and Chromatid Cohesion","description":"The top GO terms cluster around meiotic double-strand break processing for reciprocal recombination, establishment of sister chromatid cohesion, and chiasma assembly, along with multiple DNA repair and genome-stability related processes (nucleotide-excision repair, cellular response to DNA damage, telomere maintenance regulation). This combination strongly points to proteins involved in meiotic recombination and chromosomal maintenance, rather than a single isolated function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040016","count":2},{"id":"GO:0034085","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0010705","count":2},{"id":"GO:0000184","count":2}]},{"hash":"892966663601810788","title":"Unknown","description":"The terms span diverse biological contexts (gene expression regulation, neural development, mitochondrial inheritance, cell polarity, immune cell migration, vascular contraction, endosomal sorting, and morphogenesis), with no single, cohesive function tying the cluster together. This makes it inappropriate to assign a specific, representative label.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010628","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0071963","count":3},{"id":"GO:0036336","count":2}]},{"hash":"2295638397074570890","title":"Unknown","description":"The GO terms are highly diverse, spanning photosystem stoichiometry adjustment, vacuole fusion, osmosensory/MAPK signaling (obsolete), NF-kappaB and BMP/SMAD pathway regulation, peptidyl-threonine dephosphorylation, meristem maintenance, and germline masculinization. With only three proteins and no clear, cohesive biological theme linking these terms, there isn\u2019t a reliable, specific function label to assign beyond Unknown.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0080005","count":1},{"id":"GO:0061191","count":1},{"id":"GO:0000173","count":1},{"id":"GO:0042347","count":1},{"id":"GO:0010991","count":1}]},{"hash":"872343227074729781","title":"Unknown","description":"The GO terms shown span diverse, loosely related themes (cell differentiation, EMT, development of lung and muscle, DNA replication, RNA processing, intracellular trafficking, lipid metabolism, neuronal signaling, and locomotion) with no single dominant function linking the proteins. This dispersion makes it difficult to assign a specific, concise biological label for the cluster. ","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010719","count":1},{"id":"GO:1900486","count":1},{"id":"GO:0006260","count":1},{"id":"GO:1903799","count":1},{"id":"GO:0014883","count":1}]},{"hash":"97415902139021675","title":"RNA processing and transcription regulation","description":"The top GO terms cluster around RNA metabolism and transcription control: miRNA catabolic process, pre-miRNA processing, DNA-templated transcription, transcription termination, transcription antitermination, and CRD-mediated mRNA stabilization. The recurring theme is RNA processing and transcription regulation, which best explains the shared function of the proteins. A couple of terms about kidney development and osmotic-stress\u2013related apoptosis appear peripheral but do not change the core RNA-centric signal.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010587","count":3},{"id":"GO:0060567","count":3},{"id":"GO:0031564","count":3},{"id":"GO:0070934","count":3},{"id":"GO:1901724","count":3}]},{"hash":"1040459524306737525","title":"RNA Modification and Cofactor Biosynthesis","description":"The top GO terms cluster around RNA base/tRNA methylation and diverse cofactor biosynthesis (rRNA/tRNA methylation, tRNA queuosine biosynthesis, menaquinone, molybdopterin cofactor, biotin), suggesting proteins involved in RNA modification and multiple biosynthetic pathways. The lack of edges implies these annotations may reflect broader metabolic roles rather than a single, tight complex, but the shared theme centers on biosynthesis and RNA modification processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070475","count":2},{"id":"GO:0008616","count":1},{"id":"GO:0018339","count":1},{"id":"GO:0009234","count":1},{"id":"GO:0006777","count":1}]},{"hash":"841698785210282267","title":"Neural axonogenesis and synapse formation","description":"Most top terms point to neuronal development, especially axon growth/fasciculation and synapse assembly (GO:0050772, GO:0097156, GO:0051965), suggesting the cluster centers on neuronal connectivity. Some terms relate to broader development (angiogenesis, endoderm differentiation), but the neural differentiation signals dominate, supporting a label around neural axonogenesis and synapse formation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0097156","count":3},{"id":"GO:2001202","count":3},{"id":"GO:0042698","count":3},{"id":"GO:0050772","count":3}]},{"hash":"2080369124816098936","title":"Glycinergic and Serotonergic Neurotransmission","description":"The GO terms cluster around neural signaling, notably glycinergic synaptic transmission and glycine secretion, along with serotonin uptake/secretion. Additional terms about amino acid transport (taurine, leucine) and neural development/glial growth support a neural signaling and neurotransmitter-focused theme. This makes \"Glycinergic and Serotonergic Neurotransmission\" a concise, representative label.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061537","count":2},{"id":"GO:0015734","count":2},{"id":"GO:0015820","count":2},{"id":"GO:0042066","count":2},{"id":"GO:1905847","count":2}]},{"hash":"863845754641481456","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046086","count":1},{"id":"GO:0014850","count":1},{"id":"GO:0035690","count":1},{"id":"GO:0006531","count":1},{"id":"GO:0042594","count":1}]},{"hash":"1558790755932666750","title":"tRNA processing and translation (mitochondrial)","description":"The dominant terms are about RNA biology: tRNA processing, wobble modification, and mitochondrial tRNA aminoacylation, along with translation. Telomere-related terms appear but are likely less central to this cluster; overall the clearest common theme links tRNA maturation and protein synthesis, including mitochondrial charging. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070200","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0016233","count":1},{"id":"GO:0070154","count":1},{"id":"GO:0007093","count":1}]},{"hash":"592356353134790753","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0019068","count":3}]},{"hash":"2161295446801372943","title":"Mitosis and Microtubule Dynamics","description":"The set centers on cell division and microtubule function, with terms like mitotic spindle assembly checkpoint signaling, plus-end-directed vesicle transport along microtubules, and regulation of DNA replication initiation pointing to mitotic processes and microtubule dynamics as the core theme. Some entries (miRNA processing, NF-kappaB signaling, neural structure) seem less connected and may reflect broader regulatory roles or annotation noise, but the dominant pattern supports a mitosis/microtubule-focused cluster.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044810","count":2},{"id":"GO:0090055","count":2},{"id":"GO:1905150","count":2},{"id":"GO:0072383","count":2},{"id":"GO:0090282","count":2}]},{"hash":"659727226259346234","title":"RNA Pol II Transcription Regulation","description":"The terms cluster around RNA polymerase II processes\u2014initiation (PIC assembly, promoter initiation), elongation (positive regulation, fidelity maintenance), and related regulation\u2014indicating a module of transcription control by RNA Pol II. Some Pol I termination and ribosome biogenesis terms are present but secondary to the Pol II transcription theme.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051123","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0001193","count":1},{"id":"GO:0045899","count":1},{"id":"GO:0031564","count":1}]},{"hash":"1235599378273792588","title":"Actin-driven membrane remodeling and ruffle formation","description":"This cluster\u2019s terms cluster around actin dynamics and membrane-associated processes: barbed-end actin filament capping, ruffle assembly and membrane invagination, plus related processes like synaptic remodeling and phagocytic engulfment. The common theme appears to be actin-mediated membrane remodeling and protrusion/endocytosis activities across contexts, rather than a single specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":1},{"id":"GO:0051016","count":1},{"id":"GO:0010863","count":1},{"id":"GO:1900029","count":1},{"id":"GO:0097178","count":1}]},{"hash":"2094418016403151365","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090084","count":1},{"id":"GO:0046825","count":1},{"id":"GO:1901621","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0006260","count":1}]},{"hash":"2282707509892872030","title":"Mitochondrial aminoacyl-tRNA synthetases","description":"Most terms point to mitochondrial tRNA charging and translation; specifically mitochondrial lysyl-, aspartyl-, and asparaginyl-tRNA aminoacylation, along with the broader translation GO term. This indicates the cluster represents mitochondrial protein synthesis machinery centered on aminoacyl-tRNA synthetases, with a few unrelated or obsolete terms present but not overriding the main signal.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0070154","count":2},{"id":"GO:0071915","count":2},{"id":"GO:0070146","count":2},{"id":"GO:0070145","count":2}]},{"hash":"653244243971578017","title":"ABA-Responsive inositol and phosphoinositide biosynthesis","description":"These terms cluster around myo-inositol and phosphatidylinositol biosynthesis, ABA-activated signaling, and hyperosmotic/osmotic stress responses, suggesting a role in plant membrane lipid metabolism tied to abiotic stress signaling. The presence of transcription regulation and metabolic processes like gluconeogenesis and sulfate assimilation provides contextual support, though the core theme centers on lipid signaling and ABA-mediated stress response. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006021","count":1},{"id":"GO:0046855","count":1},{"id":"GO:0042538","count":1},{"id":"GO:0009738","count":1},{"id":"GO:0006094","count":1}]}]