{"hash":"2073413193295412725","title":"Endosomal trafficking and receptor signaling regulation","description":"The GO terms point to endocytic processes and regulation of receptor activity: negative regulation of growth hormone receptor signaling, negative regulation of protein localization to the cell surface, and late endosome to vacuole transport via multivesicular body sorting. Together they suggest a coherent theme of endosomal trafficking, particularly ESCRT-mediated sorting to lysosome/vacuole, which modulates surface receptor signaling. Despite only one hit per term, this common mechanism best explains the cluster\u2019s functions.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_011773451.1","go_terms":[]},{"accession":"XP_011776983.1","go_terms":[]},{"accession":"XP_011772488.1","go_terms":[]},{"accession":"XP_011778862.1","go_terms":[]},{"accession":"XP_011780955.1","go_terms":[]},{"accession":"XP_011772392.1","go_terms":[]},{"accession":"XP_011775840.1","go_terms":[]},{"accession":"XP_011772142.1","go_terms":["GO:0032511","GO:0060400","GO:2000009"]},{"accession":"XP_011774621.1","go_terms":[]},{"accession":"XP_011771755.1","go_terms":[]},{"accession":"XP_011775454.1","go_terms":[]},{"accession":"XP_011772504.1","go_terms":[]},{"accession":"XP_011774999.1","go_terms":[]},{"accession":"XP_011777209.1","go_terms":[]},{"accession":"XP_011780980.1","go_terms":[]},{"accession":"XP_011773172.1","go_terms":[]}],"graph":[],"all_go_terms":{"GO:0060400":1,"GO:2000009":1,"GO:0032511":1},"recipe_readded":["XP_011780708.1","XP_011773457.1","XP_011780129.1","XP_011780448.1","XP_011771953.1","XP_011776084.1","XP_011775358.1","XP_011776556.1","XP_011778374.1","XP_011776933.1","XP_011779742.1","XP_011779843.1","XP_011772762.1","XP_011772514.1","XP_011773752.1","XP_011772795.1","XP_011772755.1","XP_011776604.1","XP_011775853.1","XP_011776800.1"]}