{"hash":"1033319346795805400","title":"Mitotic machinery and protein homeostasis","description":"The cluster\u2019s prominent terms include cell division, CENP-A chromatin assembly, and microtubule severing, pointing to mitotic machinery. At the same time, there are processes related to protein quality control and trafficking (protein import into mitochondria, ER-to-Golgi transport, chaperone-mediated assembly, ubiquitin-dependent ERAD) and GTPase regulation, suggesting coordination of mitosis with protein folding, trafficking, and turnover. This combination supports a broader theme of cell-cycle progression linked to protein homeostasis rather than a single narrow function.","confidence":"Medium","size":14,"edges":84,"triangles":289,"max_degree":13,"top_function":null,"members":[{"accession":"XP_006676461.1","go_terms":["GO:0000722","GO:2000269","GO:0071480","GO:0009636","GO:0051106","GO:0090267","GO:0036297","GO:0000732","GO:0007294","GO:0007066","GO:0007533","GO:0007141","GO:0010165","GO:0001541","GO:1990918","GO:0009949","GO:0051260","GO:0007129","GO:0000707","GO:0001556","GO:1990426","GO:0072757","GO:0000709","GO:0072719","GO:0010569","GO:0072711","GO:0007286","GO:0042148","GO:0007131","GO:0007130","GO:1904631","GO:0090656","GO:0009951","GO:0045003","GO:0006268","GO:0001832","GO:0030491","GO:0042493","GO:0030717","GO:1990414","GO:0001932","GO:0071140"]},{"accession":"XP_006676841.1","go_terms":["GO:0016183","GO:0006886","GO:0072583"]},{"accession":"XP_006676923.1","go_terms":["GO:0035392","GO:0031990","GO:0036228","GO:0030328","GO:0035080","GO:0006607","GO:0000061","GO:0000973","GO:0007184","GO:0000082","GO:0033132","GO:0007051","GO:0046604","GO:1901181","GO:0090526","GO:0043547","GO:0000042","GO:0006511","GO:0006405"]},{"accession":"XP_006677375.1","go_terms":[]},{"accession":"XP_006677457.1","go_terms":[]},{"accession":"XP_006677823.1","go_terms":[]},{"accession":"XP_006679260.1","go_terms":[]},{"accession":"XP_006680121.1","go_terms":[]},{"accession":"XP_006680468.1","go_terms":[]},{"accession":"XP_006680872.1","go_terms":[]},{"accession":"XP_006681030.1","go_terms":["GO:0019068","GO:1904851","GO:0050821","GO:1904874","GO:1904871","GO:0071866","GO:0090666","GO:1901998","GO:0051301","GO:0044053","GO:0050729","GO:0046931","GO:0051085","GO:0051086","GO:0032212","GO:0007049","GO:0048291","GO:0046686","GO:1903427","GO:0051973","GO:0051131","GO:0014823","GO:1904469","GO:0007339","GO:0002842","GO:0042220","GO:0009408","GO:0002931","GO:0052212","GO:0045041","GO:0002368","GO:0002236","GO:2000778","GO:0042026","GO:0033198"]},{"accession":"XP_006681620.1","go_terms":["GO:2001235","GO:0021510","GO:0008584","GO:0001501","GO:0035264","GO:0051568","GO:0051567","GO:0038202","GO:0040020","GO:0007369","GO:0000920","GO:0010255","GO:0060528","GO:0032933","GO:0043966","GO:2000728","GO:0000462","GO:0000463","GO:0000466","GO:0030042","GO:0070734","GO:0050731","GO:0001845","GO:0000398","GO:0007200","GO:0060416","GO:0034314","GO:0036265","GO:0090344","GO:0031954","GO:0048568","GO:0034316","GO:0035246","GO:0061641","GO:0000472","GO:0031175","GO:0007064","GO:0060770","GO:0002534","GO:0006888","GO:0043547","GO:2000011","GO:0042254","GO:0016575","GO:1903461","GO:0071456","GO:0061099","GO:0001843","GO:0048705","GO:0060271","GO:0006625","GO:2001162","GO:0070208","GO:0071276","GO:0010659","GO:0090114","GO:0006890","GO:0000132","GO:0007420","GO:0031081","GO:0043982","GO:0001403","GO:0043981","GO:0061087","GO:0006351","GO:0000480","GO:1901976","GO:0034729","GO:0031930","GO:1904263","GO:0060041","GO:0031497","GO:2001125","GO:1902525","GO:0000209","GO:0042273","GO:0006349","GO:0000724","GO:0002188","GO:0043984","GO:2000601","GO:0008283","GO:0051013","GO:0070306","GO:0031146","GO:0031145","GO:0007338","GO:0045143","GO:1902510","GO:0043473","GO:0007568","GO:0050679","GO:0070059","GO:0061586","GO:0071560","GO:0070317","GO:0090307","GO:0060733","GO:0071902","GO:0072520","GO:0000348","GO:0050909","GO:0007275","GO:0001649","GO:0000747","GO:0070262","GO:0051260","GO:0051301","GO:1904668","GO:0043588","GO:0000278","GO:0034349","GO:0007584","GO:0051402","GO:0030433","GO:0000447","GO:0001731","GO:0032995","GO:0000070","GO:0072432","GO:0051028","GO:0035948","GO:0007018","GO:0050830","GO:0030900","GO:0075525","GO:0006446","GO:0030707","GO:0075522","GO:0046784","GO:0030157","GO:1905705","GO:1902426","GO:0035185","GO:0070979","GO:0032466","GO:0008284","GO:0035721","GO:0051016","GO:0051441","GO:0050773","GO:2000060","GO:0010697","GO:0031915"]},{"accession":"XP_006682158.1","go_terms":["GO:0061738","GO:0031117","GO:0051260","GO:0030420","GO:2001171","GO:0034214","GO:1903862","GO:0032968","GO:0070842","GO:0001824","GO:0006260","GO:0034551","GO:0070682","GO:0033314","GO:0032979","GO:0051013","GO:0046034","GO:1901800","GO:1990171","GO:0016485","GO:0045899","GO:0030968","GO:0006272","GO:0070987","GO:0043335","GO:0070676","GO:0070370","GO:1903007","GO:0090261","GO:0070914","GO:0061641","GO:0061166","GO:1903715","GO:0051301","GO:0006888","GO:0045053","GO:0001319","GO:0035494","GO:0019079","GO:0070414","GO:0097352","GO:0071218","GO:0016562","GO:2000158","GO:0070389","GO:0018279","GO:0006406","GO:0051131","GO:0048219","GO:0030433","GO:1903724","GO:0034599","GO:0090296","GO:0072389","GO:0045041","GO:0016558","GO:0000733","GO:0070407","GO:0070651","GO:0071712","GO:0035617"]},{"accession":"XP_006682824.1","go_terms":[]}],"graph":[["XP_006682158.1","XP_006676461.1",0.963],["XP_006682158.1","XP_006676841.1",0.943],["XP_006682158.1","XP_006676923.1",0.977],["XP_006682158.1","XP_006677375.1",0.98],["XP_006682158.1","XP_006677457.1",0.902],["XP_006682158.1","XP_006677823.1",0.684],["XP_006682158.1","XP_006679260.1",0.963],["XP_006682158.1","XP_006680121.1",0.978],["XP_006682158.1","XP_006680468.1",0.962],["XP_006682158.1","XP_006680872.1",0.986],["XP_006682158.1","XP_006681030.1",0.76],["XP_006682158.1","XP_006681620.1",0.919],["XP_006682158.1","XP_006682824.1",0.689],["XP_006679260.1","XP_006676461.1",0.93],["XP_006679260.1","XP_006676841.1",0.648],["XP_006679260.1","XP_006676923.1",0.891],["XP_006679260.1","XP_006677375.1",0.663],["XP_006679260.1","XP_006677457.1",0.692],["XP_006679260.1","XP_006677823.1",0.728],["XP_006679260.1","XP_006680121.1",0.702],["XP_006679260.1","XP_006680872.1",0.962],["XP_006679260.1","XP_006681030.1",0.923],["XP_006679260.1","XP_006682824.1",0.945],["XP_006676841.1","XP_006676461.1",0.887],["XP_006676841.1","XP_006676923.1",0.84],["XP_006676841.1","XP_006677375.1",0.644],["XP_006676841.1","XP_006677457.1",0.709],["XP_006676841.1","XP_006677823.1",0.756],["XP_006676841.1","XP_006680121.1",0.709],["XP_006676841.1","XP_006680872.1",0.902],["XP_006676841.1","XP_006681030.1",0.968],["XP_006676841.1","XP_006681620.1",0.656],["XP_006676841.1","XP_006682824.1",0.868],["XP_006677457.1","XP_006676461.1",0.898],["XP_006677457.1","XP_006676923.1",0.9],["XP_006677457.1","XP_006677375.1",0.705],["XP_006677457.1","XP_006677823.1",0.935],["XP_006677457.1","XP_006682824.1",0.928],["XP_006677457.1","XP_006681620.1",0.911],["XP_006677457.1","XP_006680872.1",0.906],["XP_006677457.1","XP_006681030.1",0.955],["XP_006677457.1","XP_006680468.1",0.906],["XP_006677457.1","XP_006680121.1",0.68],["XP_006681620.1","XP_006676461.1",0.951],["XP_006681620.1","XP_006676923.1",0.876],["XP_006681620.1","XP_006677375.1",0.754],["XP_006681620.1","XP_006677823.1",0.79],["XP_006681620.1","XP_006680121.1",0.676],["XP_006681620.1","XP_006680872.1",0.962],["XP_006681620.1","XP_006681030.1",0.958],["XP_006681620.1","XP_006682824.1",0.842],["XP_006680121.1","XP_006676461.1",0.816],["XP_006680121.1","XP_006676923.1",0.943],["XP_006680121.1","XP_006677375.1",0.712],["XP_006680121.1","XP_006677823.1",0.63],["XP_006680121.1","XP_006680468.1",0.596],["XP_006680121.1","XP_006680872.1",0.977],["XP_006680121.1","XP_006681030.1",0.952],["XP_006680121.1","XP_006682824.1",0.928],["XP_006680468.1","XP_006676461.1",0.654],["XP_006680468.1","XP_006676923.1",0.844],["XP_006680468.1","XP_006677375.1",0.589],["XP_006680468.1","XP_006682824.1",0.617],["XP_006680468.1","XP_006680872.1",0.921],["XP_006680468.1","XP_006681030.1",0.854],["XP_006676461.1","XP_006677823.1",0.95],["XP_006676461.1","XP_006677375.1",0.901],["XP_006676461.1","XP_006676923.1",0.953],["XP_006676461.1","XP_006682824.1",0.963],["XP_006676461.1","XP_006680872.1",0.989],["XP_006676461.1","XP_006681030.1",0.9],["XP_006681030.1","XP_006676923.1",0.977],["XP_006681030.1","XP_006677375.1",0.91],["XP_006681030.1","XP_006680872.1",0.98],["XP_006676923.1","XP_006677823.1",0.921],["XP_006676923.1","XP_006677375.1",0.95],["XP_006676923.1","XP_006680872.1",0.883],["XP_006676923.1","XP_006682824.1",0.955],["XP_006682824.1","XP_006677375.1",0.954],["XP_006682824.1","XP_006677823.1",0.957],["XP_006682824.1","XP_006680872.1",0.987],["XP_006677823.1","XP_006677375.1",0.869],["XP_006677823.1","XP_006680872.1",0.974],["XP_006677375.1","XP_006680872.1",0.973]],"all_go_terms":{"GO:0071480":1,"GO:0010569":1,"GO:0001541":1,"GO:1990918":1,"GO:0007131":1,"GO:0072711":1,"GO:0007066":1,"GO:0009949":1,"GO:0072757":1,"GO:0036297":1,"GO:0007130":1,"GO:0009951":1,"GO:0072719":1,"GO:1904631":1,"GO:0042493":1,"GO:0007129":1,"GO:0051260":3,"GO:0042148":1,"GO:0007286":1,"GO:0090656":1,"GO:0045003":1,"GO:0007533":1,"GO:0009636":1,"GO:0000709":1,"GO:0001932":1,"GO:0007294":1,"GO:0010165":1,"GO:0000732":1,"GO:0090267":1,"GO:0001556":1,"GO:0007141":1,"GO:0030717":1,"GO:0001832":1,"GO:0030491":1,"GO:0071140":1,"GO:0000707":1,"GO:1990414":1,"GO:0006268":1,"GO:2000269":1,"GO:0051106":1,"GO:0000722":1,"GO:1990426":1,"GO:0016183":1,"GO:0072583":1,"GO:0006886":1,"GO:0006607":1,"GO:0090526":1,"GO:0035392":1,"GO:0007184":1,"GO:0046604":1,"GO:0033132":1,"GO:0000061":1,"GO:0006405":1,"GO:0043547":2,"GO:0030328":1,"GO:0000973":1,"GO:0036228":1,"GO:0031990":1,"GO:0000042":1,"GO:0000082":1,"GO:0006511":1,"GO:0035080":1,"GO:0007051":1,"GO:1901181":1,"GO:0014823":1,"GO:0050821":1,"GO:1903427":1,"GO:0002236":1,"GO:0042220":1,"GO:0007339":1,"GO:0051973":1,"GO:0046686":1,"GO:0002931":1,"GO:0002368":1,"GO:0007049":1,"GO:0048291":1,"GO:0051086":1,"GO:1904851":1,"GO:1904874":1,"GO:0090666":1,"GO:1904469":1,"GO:0052212":1,"GO:0071866":1,"GO:0050729":1,"GO:0009408":1,"GO:0044053":1,"GO:1904871":1,"GO:0045041":2,"GO:2000778":1,"GO:0019068":1,"GO:0051301":3,"GO:0051131":2,"GO:0042026":1,"GO:0032212":1,"GO:0033198":1,"GO:1901998":1,"GO:0051085":1,"GO:0002842":1,"GO:0046931":1,"GO:0032466":1,"GO:0072432":1,"GO:2000011":1,"GO:0000278":1,"GO:0001649":1,"GO:0070059":1,"GO:0038202":1,"GO:0034349":1,"GO:0008584":1,"GO:0036265":1,"GO:0050679":1,"GO:0030433":2,"GO:0008283":1,"GO:0042254":1,"GO:0001731":1,"GO:0007568":1,"GO:1902525":1,"GO:0006349":1,"GO:0031145":1,"GO:0061586":1,"GO:0000348":1,"GO:0046784":1,"GO:2000728":1,"GO:0032995":1,"GO:0043966":1,"GO:0043982":1,"GO:0051028":1,"GO:1904668":1,"GO:0051568":1,"GO:0001845":1,"GO:0071276":1,"GO:0071560":1,"GO:0051013":2,"GO:0002188":1,"GO:0010255":1,"GO:0035948":1,"GO:1905705":1,"GO:0051402":1,"GO:0072520":1,"GO:0043473":1,"GO:2001125":1,"GO:0031954":1,"GO:0061641":2,"GO:0016575":1,"GO:0090344":1,"GO:0060271":1,"GO:0031146":1,"GO:0030157":1,"GO:2000060":1,"GO:0060041":1,"GO:1902510":1,"GO:0000447":1,"GO:0090114":1,"GO:0001403":1,"GO:0060770":1,"GO:0000398":1,"GO:0031930":1,"GO:0051016":1,"GO:0060528":1,"GO:0006890":1,"GO:1901976":1,"GO:0070317":1,"GO:0045143":1,"GO:0050830":1,"GO:0030042":1,"GO:2000601":1,"GO:0007338":1,"GO:0000132":1,"GO:0042273":1,"GO:0051441":1,"GO:0034729":1,"GO:2001235":1,"GO:0043588":1,"GO:0007369":1,"GO:0000920":1,"GO:0000724":1,"GO:0075522":1,"GO:0071456":1,"GO:0008284":1,"GO:1903461":1,"GO:0002534":1,"GO:0006446":1,"GO:0006888":2,"GO:0001843":1,"GO:0051567":1,"GO:0007200":1,"GO:2001162":1,"GO:0060733":1,"GO:0031081":1,"GO:0000209":1,"GO:0000070":1,"GO:0075525":1,"GO:0000466":1,"GO:0031175":1,"GO:0070306":1,"GO:0006625":1,"GO:0090307":1,"GO:0050773":1,"GO:0032933":1,"GO:0070262":1,"GO:0010697":1,"GO:1902426":1,"GO:0000463":1,"GO:0040020":1,"GO:0034314":1,"GO:0050731":1,"GO:0010659":1,"GO:0000747":1,"GO:0035264":1,"GO:0035185":1,"GO:0043981":1,"GO:0043984":1,"GO:0000472":1,"GO:0070208":1,"GO:0070979":1,"GO:0060416":1,"GO:0048568":1,"GO:0021510":1,"GO:0031497":1,"GO:0006351":1,"GO:0007018":1,"GO:0030900":1,"GO:0007275":1,"GO:0061099":1,"GO:0035721":1,"GO:0007584":1,"GO:0007064":1,"GO:0061087":1,"GO:0035246":1,"GO:0048705":1,"GO:0070734":1,"GO:0030707":1,"GO:0050909":1,"GO:0071902":1,"GO:0034316":1,"GO:0000480":1,"GO:0001501":1,"GO:0000462":1,"GO:0007420":1,"GO:1904263":1,"GO:0031915":1,"GO:0070676":1,"GO:0070842":1,"GO:0045899":1,"GO:0006272":1,"GO:1903862":1,"GO:0046034":1,"GO:0070914":1,"GO:0016562":1,"GO:0070414":1,"GO:0033314":1,"GO:2000158":1,"GO:0031117":1,"GO:0032968":1,"GO:0001319":1,"GO:0071712":1,"GO:0070651":1,"GO:0045053":1,"GO:0090296":1,"GO:2001171":1,"GO:0043335":1,"GO:0070389":1,"GO:0035494":1,"GO:0030420":1,"GO:0016485":1,"GO:0019079":1,"GO:0061738":1,"GO:0034599":1,"GO:0070682":1,"GO:0070407":1,"GO:1901800":1,"GO:0016558":1,"GO:0000733":1,"GO:0097352":1,"GO:0001824":1,"GO:0030968":1,"GO:0034551":1,"GO:0006406":1,"GO:1990171":1,"GO:0034214":1,"GO:1903715":1,"GO:0006260":1,"GO:1903724":1,"GO:0072389":1,"GO:0071218":1,"GO:0070370":1,"GO:0035617":1,"GO:0032979":1,"GO:0090261":1,"GO:0061166":1,"GO:0070987":1,"GO:1903007":1,"GO:0048219":1,"GO:0018279":1},"recipe_readded":[]}