{"hash":"793414124125065041","title":"Lysosomal trafficking and autophagy","description":"The cluster\u2019s GO terms cluster around lysosome biology and vesicular transport, including lysosome localization, lysosomal lumen acidification, endosome-to-lysosome transport, autophagosome maturation, and secretion of lysosomal enzymes, as well as intracellular protein transport. The presence of retrograde axonal transport and synaptic vesicle fusion to the presynaptic membrane suggests broader vesicle trafficking roles in neurons. A couple of terms related to pigment cell differentiation and NK cell activation appear peripheral but may reflect context-dependent roles of vesicle trafficking in different cell types. Overall, the proteins seem to form a group centered on lysosome-associated trafficking and autophagy.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"members":[{"accession":"XP_012654418.1","go_terms":["GO:0007042","GO:0030318","GO:0035646","GO:0032816","GO:0016188","GO:0050942","GO:0072553","GO:0008333","GO:0032418","GO:0031629","GO:0033299","GO:1902774","GO:0048490","GO:0008057","GO:0097352","GO:0006886","GO:0008090"]},{"accession":"XP_001009800.2","go_terms":[]},{"accession":"XP_001020481.2","go_terms":["GO:0018393","GO:0051606","GO:0009736","GO:0080117","GO:0000160","GO:0006355","GO:0043158","GO:0030435","GO:0006351","GO:0042173","GO:0010105","GO:0006808","GO:0071973","GO:0006935","GO:0006457","GO:0017006","GO:0035690","GO:0046777","GO:0009585","GO:0070483","GO:0071353","GO:0006265","GO:0006261","GO:0097411","GO:0033160","GO:0009584","GO:0018298","GO:1903660","GO:0042220","GO:0007059","GO:0001890","GO:0045793","GO:1901389","GO:0010510","GO:0006006","GO:1905323","GO:0016310","GO:0010271","GO:0034757"]},{"accession":"XP_001025517.3","go_terms":[]},{"accession":"XP_001031123.3","go_terms":["GO:0071421","GO:0071281","GO:0030026","GO:0006880","GO:0071369"]},{"accession":"XP_012652177.1","go_terms":[]},{"accession":"XP_012652848.1","go_terms":[]},{"accession":"XP_976882.2","go_terms":[]},{"accession":"XP_001012714.1","go_terms":[]}],"graph":[["XP_001031123.3","XP_012654418.1",0.817],["XP_001025517.3","XP_012654418.1",0.714],["XP_001020481.2","XP_012654418.1",0.871],["XP_012652848.1","XP_012654418.1",0.867],["XP_012654418.1","XP_012652177.1",0.537],["XP_012654418.1","XP_976882.2",0.661],["XP_012654418.1","XP_001009800.2",0.542],["XP_012654418.1","XP_001012714.1",0.905]],"all_go_terms":{"GO:0033299":1,"GO:0097352":1,"GO:0008333":1,"GO:0031629":1,"GO:0008090":1,"GO:0007042":1,"GO:0050942":1,"GO:0006886":1,"GO:0032418":1,"GO:0032816":1,"GO:0048490":1,"GO:0008057":1,"GO:1902774":1,"GO:0035646":1,"GO:0030318":1,"GO:0016188":1,"GO:0072553":1,"GO:1901389":1,"GO:0030435":1,"GO:0046777":1,"GO:1905323":1,"GO:0000160":1,"GO:0034757":1,"GO:0035690":1,"GO:0007059":1,"GO:0071353":1,"GO:0017006":1,"GO:0006265":1,"GO:0001890":1,"GO:0006935":1,"GO:0018298":1,"GO:0006355":1,"GO:0006808":1,"GO:0042173":1,"GO:0097411":1,"GO:0009585":1,"GO:0042220":1,"GO:0006006":1,"GO:0009584":1,"GO:0010271":1,"GO:0018393":1,"GO:0006351":1,"GO:0006457":1,"GO:0009736":1,"GO:0033160":1,"GO:0043158":1,"GO:0045793":1,"GO:0080117":1,"GO:0071973":1,"GO:0010105":1,"GO:0070483":1,"GO:1903660":1,"GO:0006261":1,"GO:0016310":1,"GO:0051606":1,"GO:0010510":1,"GO:0071421":1,"GO:0006880":1,"GO:0030026":1,"GO:0071281":1,"GO:0071369":1},"recipe_readded":[]}