{"hash":"232242573252640884","title":"JNK/MAPK stress signaling and apoptosis","description":"The cluster\u2019s prominent GO terms center on the JNK cascade, and on an intrinsic apoptotic pathway in response to DNA damage, highlighting a theme of stress-activated signaling leading to cell death. Additional terms such as response to lipopolysaccharide and response to absence of light suggest broader stress or immune signaling. Deneddylation and its regulation point to control of protein turnover and signaling, which can modulate MAPK pathways. Some germline development terms are present but appear less central to the main theme. Overall, the cluster is best described by stress-activated MAPK/JNK signaling and apoptosis.","confidence":"Medium","size":27,"edges":26,"triangles":0,"max_degree":26,"top_function":null,"members":[{"accession":"XP_001021901.2","go_terms":["GO:0034260","GO:0000338","GO:0007254","GO:0060625","GO:0000188","GO:0048142","GO:0009646","GO:0048140"]},{"accession":"XP_001009041.1","go_terms":[]},{"accession":"XP_012651173.1","go_terms":[]},{"accession":"XP_012652531.1","go_terms":[]},{"accession":"XP_012654608.1","go_terms":[]},{"accession":"XP_001009934.1","go_terms":["GO:0042347","GO:0033209","GO:0034051","GO:0071222","GO:0042771"]},{"accession":"XP_001010086.2","go_terms":[]},{"accession":"XP_001011859.2","go_terms":[]},{"accession":"XP_001012496.2","go_terms":[]},{"accession":"XP_001013599.2","go_terms":["GO:0030323","GO:0060437","GO:0090263","GO:1905609","GO:0060670","GO:1990874","GO:0030282","GO:0001649","GO:0042489","GO:2000052","GO:0002001","GO:0060441","GO:0002040","GO:0033336","GO:0033337","GO:0033335","GO:0033339","GO:0035115","GO:0035116","GO:0002090","GO:0042089","GO:0071542","GO:0035878","GO:0001974","GO:0060535","GO:0033340"]},{"accession":"XP_001016468.2","go_terms":[]},{"accession":"XP_001019431.2","go_terms":["GO:0009831","GO:0042546","GO:0031505","GO:0032491","GO:0010411","GO:0006037","GO:0006078"]},{"accession":"XP_001020283.2","go_terms":[]},{"accession":"XP_001023580.2","go_terms":[]},{"accession":"XP_001026544.2","go_terms":[]},{"accession":"XP_001023020.3","go_terms":["GO:0016319","GO:0000186","GO:0043547","GO:0035735","GO:0032008","GO:0071230"]},{"accession":"XP_001016462.1","go_terms":[]},{"accession":"XP_001019598.1","go_terms":[]},{"accession":"XP_001020394.1","go_terms":[]},{"accession":"XP_001021568.1","go_terms":[]},{"accession":"XP_001025530.2","go_terms":["GO:0006954","GO:0051607","GO:0034138","GO:0042116","GO:1902350","GO:0034154","GO:0034158","GO:0008063","GO:0050729","GO:0045078","GO:0050707","GO:0010080","GO:0006963","GO:0002322","GO:0032722","GO:0043330","GO:0032741","GO:0045087","GO:1900155","GO:0034162","GO:0050830","GO:0034166","GO:0034142","GO:0007352","GO:0002730","GO:0009729","GO:0002755","GO:0002756","GO:0045416","GO:0045356","GO:0045359","GO:0009620","GO:0048833","GO:0009934","GO:0032621","GO:0071225","GO:2000321","GO:0061303","GO:0034134","GO:0030335","GO:0050701","GO:2000813","GO:0002606","GO:0051639","GO:0051638","GO:0032498","GO:0030011","GO:0050829","GO:0044546","GO:0043086","GO:0051770","GO:0006404","GO:0045345","GO:0002374","GO:0006409","GO:0043124","GO:0006407","GO:0032760","GO:0031146","GO:0032611","GO:0002830","GO:0042228","GO:0060335","GO:0035882","GO:0050711","GO:0042345","GO:0031663","GO:0050718","GO:0016045","GO:0032088","GO:1904417","GO:0046827","GO:0032715","GO:0070431","GO:1902745","GO:0032755"]},{"accession":"XP_001027830.1","go_terms":["GO:0002803","GO:0007586","GO:0019886","GO:0002018","GO:0016540","GO:0001823","GO:0002003","GO:0033619","GO:0070305","GO:0042985","GO:0042756","GO:0002016","GO:0050435"]},{"accession":"XP_012650659.1","go_terms":[]},{"accession":"XP_012656149.1","go_terms":[]},{"accession":"XP_001012013.2","go_terms":[]},{"accession":"XP_012654516.1","go_terms":[]},{"accession":"XP_001028404.2","go_terms":[]}],"graph":[["XP_001009041.1","XP_001021901.2",0.838],["XP_012654516.1","XP_001021901.2",0.591],["XP_001011859.2","XP_001021901.2",0.54],["XP_012650659.1","XP_001021901.2",0.622],["XP_001023020.3","XP_001021901.2",0.83],["XP_001021568.1","XP_001021901.2",0.523],["XP_001016468.2","XP_001021901.2",0.962],["XP_001025530.2","XP_001021901.2",0.554],["XP_012651173.1","XP_001021901.2",0.606],["XP_012652531.1","XP_001021901.2",0.923],["XP_001013599.2","XP_001021901.2",0.533],["XP_001019598.1","XP_001021901.2",0.699],["XP_001019431.2","XP_001021901.2",0.618],["XP_001009934.1","XP_001021901.2",0.634],["XP_001020283.2","XP_001021901.2",0.831],["XP_001012013.2","XP_001021901.2",0.553],["XP_012656149.1","XP_001021901.2",0.591],["XP_001027830.1","XP_001021901.2",0.767],["XP_001026544.2","XP_001021901.2",0.945],["XP_001020394.1","XP_001021901.2",0.528],["XP_001010086.2","XP_001021901.2",0.816],["XP_012654608.1","XP_001021901.2",0.647],["XP_001028404.2","XP_001021901.2",0.516],["XP_001023580.2","XP_001021901.2",0.587],["XP_001012496.2","XP_001021901.2",0.803],["XP_001016462.1","XP_001021901.2",0.76]],"all_go_terms":{"GO:0000188":1,"GO:0000338":1,"GO:0060625":1,"GO:0048140":1,"GO:0034260":1,"GO:0048142":1,"GO:0007254":1,"GO:0009646":1,"GO:0042771":1,"GO:0071222":1,"GO:0034051":1,"GO:0042347":1,"GO:0033209":1,"GO:0033337":1,"GO:0035116":1,"GO:0035878":1,"GO:0030282":1,"GO:0035115":1,"GO:0071542":1,"GO:0042089":1,"GO:2000052":1,"GO:0030323":1,"GO:0002001":1,"GO:0001649":1,"GO:0060441":1,"GO:1990874":1,"GO:0060670":1,"GO:1905609":1,"GO:0002090":1,"GO:0033339":1,"GO:0060535":1,"GO:0033335":1,"GO:0002040":1,"GO:0001974":1,"GO:0042489":1,"GO:0033340":1,"GO:0090263":1,"GO:0033336":1,"GO:0060437":1,"GO:0010411":1,"GO:0009831":1,"GO:0031505":1,"GO:0006078":1,"GO:0042546":1,"GO:0032491":1,"GO:0006037":1,"GO:0032008":1,"GO:0016319":1,"GO:004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