{"hash":"1272693350956115199","title":"ER Stress and Protein Folding","description":"This cluster is biased toward proteostasis and endoplasmic reticulum (ER) stress responses, with terms like negative regulation of ER stress-induced apoptotic signaling and chaperone/cofactor-dependent protein refolding, plus post-translational protein targeting to membranes. While other terms (e.g., DNA replication, iron-sulfur cluster assembly) appear, the strongest signal centers on protein quality control and stress signaling in the secretory pathway, supporting a proteostasis-related cluster label.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"XP_001023071.2","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_001024911.2","go_terms":["GO:0010584","GO:0006487","GO:0046706","GO:0046712","GO:0071405","GO:0046032","GO:0009901","GO:0006256"]},{"accession":"XP_001008245.1","go_terms":[]}],"graph":[["XP_001023071.2","XP_001024911.2",0.714]],"all_go_terms":{"GO:1903382":1,"GO:0070389":1,"GO:0000742":1,"GO:0006880":1,"GO:1902037":1,"GO:1903751":1,"GO:0031204":1,"GO:0000902":1,"GO:0006260":1,"GO:0016226":1,"GO:1900035":1,"GO:0090084":1,"GO:0034620":1,"GO:0006616":1,"GO:0070880":1,"GO:0046032":1,"GO:0046706":1,"GO:0071405":1,"GO:0006256":1,"GO:0009901":1,"GO:0006487":1,"GO:0046712":1,"GO:0010584":1},"recipe_readded":["XP_001013997.2","XP_012654910.1","XP_001026028.2","XP_001008654.2","XP_001021454.2","XP_001014256.3","XP_001009096.2","XP_001016987.2","XP_001033293.2","XP_012652516.1","XP_001016325.2","XP_001015003.2","XP_012651016.1","XP_001016971.2","XP_001009097.2","XP_001021814.2","XP_001033178.2","XP_001012023.2","XP_001007601.2","XP_001029709.2"]}