{"hash":"2100515823908315021","title":"Membrane Proteolysis and Calcium-Dependent Signaling","description":"The cluster's GO terms emphasize membrane protein proteolysis (ectodomain and intracellular), retrograde proteolysis from ER to cytosol, and positive regulation of the calcineurin-NFAT signaling cascade, along with calcium-regulated lysosome exocytosis and autophagosome engulfment. Together, these point to proteins involved in regulated membrane proteolysis linked to calcium-dependent signaling and vesicle trafficking, with a secondary tie to immune modulation. ","confidence":"Medium","size":10,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"members":[{"accession":"XP_004988438.1","go_terms":["GO:0050776","GO:1904211","GO:0051533","GO:0006509","GO:0070886","GO:0031293"]},{"accession":"XP_004994332.1","go_terms":["GO:0032024","GO:0035773","GO:0006906","GO:0034351","GO:0031340","GO:0048260","GO:0016188","GO:0002669","GO:0032443","GO:2000238","GO:2000235","GO:0034517","GO:0061736","GO:0032425","GO:0048174","GO:0046488","GO:0060313","GO:0046642","GO:0098746","GO:0001302","GO:0032228","GO:0045723","GO:0060304","GO:1903861","GO:0007340","GO:0007343","GO:0006886","GO:0002432","GO:0045945","GO:0021814","GO:0002337","GO:0030579","GO:0071277","GO:0010796","GO:0010794","GO:0010793","GO:0032959","GO:0009789","GO:0001324","GO:0001778","GO:0007520","GO:0007420","GO:0016540","GO:0043314","GO:0090119","GO:0030948","GO:1990926","GO:1990927","GO:0002692","GO:1905433","GO:2000300","GO:2000203","GO:1901002","GO:0035023","GO:0043087","GO:0007416","GO:0009395","GO:0036324","GO:0048015","GO:0043619","GO:0099526","GO:0099525","GO:0006646","GO:1904468","GO:0016082","GO:0060291","GO:0046580","GO:0072699","GO:1900122","GO:0045943","GO:1905415","GO:0031384","GO:0046470","GO:0016525","GO:0038026","GO:0061753","GO:0050861","GO:1905171","GO:0038028","GO:0061511","GO:0014059","GO:0050764","GO:0009738","GO:0035249","GO:0043065","GO:0071236","GO:1902479","GO:0070086","GO:0060963","GO:0007269","GO:0002316","GO:0021997","GO:0090158","GO:0090153","GO:0046456","GO:0031914","GO:0032366"]},{"accession":"XP_004990992.1","go_terms":[]},{"accession":"XP_004996698.1","go_terms":["GO:0002037","GO:0006888","GO:0008631","GO:0010917"]},{"accession":"XP_004990381.1","go_terms":[]},{"accession":"XP_004995120.1","go_terms":[]},{"accession":"XP_004996775.1","go_terms":[]},{"accession":"XP_004998805.1","go_terms":[]},{"accession":"XP_004991439.1","go_terms":[]},{"accession":"XP_004991977.1","go_terms":[]}],"graph":[["XP_004994332.1","XP_004990381.1",0.83],["XP_004994332.1","XP_004990992.1",0.927],["XP_004994332.1","XP_004998805.1",0.946],["XP_004994332.1","XP_004995120.1",0.672],["XP_004991439.1","XP_004990381.1",0.603],["XP_004991439.1","XP_004996698.1",0.67],["XP_004991977.1","XP_004990381.1",0.606],["XP_004996775.1","XP_004990381.1",0.848],["XP_004996775.1","XP_004998805.1",0.616],["XP_004988438.1","XP_004990381.1",0.776]],"all_go_terms":{"GO:0006509":1,"GO:0050776":1,"GO:0031293":1,"GO:0070886":1,"GO:1904211":1,"GO:0051533":1,"GO:0043087":1,"GO:0009789":1,"GO:1990927":1,"GO:0061736":1,"GO:0045945":1,"GO:0035773":1,"GO:0090158":1,"GO:1903861":1,"GO:0035023":1,"GO:1905433":1,"GO:0048015":1,"GO:0007420":1,"GO:0021997":1,"GO:0031914":1,"GO:0061753":1,"GO:1902479":1,"GO:0060291":1,"GO:0006906":1,"GO:0007520":1,"GO:0050861":1,"GO:0045723":1,"GO:0010794":1,"GO:1901002":1,"GO:0071277":1,"GO:0048260":1,"GO:0030948":1,"GO:0007343":1,"GO:0016082":1,"GO:0016188":1,"GO:0036324":1,"GO:0099526":1,"GO:1905415":1,"GO:0046642":1,"GO:0009738":1,"GO:0007269":1,"GO:0031340":1,"GO:0090119":1,"GO:0031384":1,"GO:0032228":1,"GO:0060313":1,"GO:0045943":1,"GO:0034517":1,"GO:0032425":1,"GO:0043314":1,"GO:0007340":1,"GO:2000235":1,"GO:0006646":1,"GO:0002316":1,"GO:0043065":1,"GO:1905171":1,"GO:0021814":1,"GO:0032959":1,"GO:0032024":1,"GO:0002669":1,"GO:2000238":1,"GO:0030579":1,"GO:0038026":1,"GO:0046456":1,"GO:0010793":1,"GO:0001778":1,"GO:0016540":1,"GO:0035249":1,"GO:0002432":1,"GO:0032443":1,"GO:0001302":1,"GO:0046488":1,"GO:0007416":1,"GO:0061511":1,"GO:0034351":1,"GO:0009395":1,"GO:0070086":1,"GO:0098746":1,"GO:0099525":1,"GO:0032366":1,"GO:1990926":1,"GO:0010796":1,"GO:0038028":1,"GO:0002337":1,"GO:0046470":1,"GO:0060304":1,"GO:0072699":1,"GO:0048174":1,"GO:0001324":1,"GO:0006886":1,"GO:0043619":1,"GO:0071236":1,"GO:0016525":1,"GO:0050764":1,"GO:0002692":1,"GO:0046580":1,"GO:1900122":1,"GO:0090153":1,"GO:2000203":1,"GO:1904468":1,"GO:0060963":1,"GO:2000300":1,"GO:0014059":1,"GO:0006888":1,"GO:0008631":1,"GO:0002037":1,"GO:0010917":1},"recipe_readded":[]}