{"hash":"146486608178603528","title":"Proteasome- and immune-signaling cluster","description":"This cluster prominently groups proteasome- and ubiquitin-related processes (protein deubiquitination; proteasomal ubiquitin-independent protein catabolic process; proteasome core complex assembly) with immune signaling and antigen processing pathways (non-canonical NF-kappaB signaling; T cell receptor signaling; Fc-epsilon receptor signaling; antigen processing and presentation via MHC class I, TAP-dependent). It also includes cell-cycle regulation (negative regulation of G2/M transition) and metabolic regulation (regulation of amino acid metabolic process), plus a salt-stress response term. The combination suggests a module where proteasome and deubiquitination activities control immune signaling and antigen presentation, potentially coordinated with cell-cycle control during immune activation.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"members":[{"accession":"XP_004992553.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_004995970.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_004997060.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_004998595.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_004992462.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_004993458.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_004994983.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_004995582.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_004997647.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]}],"graph":[["XP_004994983.1","XP_004992462.1",0.918],["XP_004994983.1","XP_004992553.1",0.923],["XP_004994983.1","XP_004993458.1",0.925],["XP_004994983.1","XP_004995582.1",0.972],["XP_004994983.1","XP_004995970.1",0.977],["XP_004994983.1","XP_004997060.1",0.762],["XP_004994983.1","XP_004997647.1",0.791],["XP_004994983.1","XP_004998595.1",0.896],["XP_004997060.1","XP_004992462.1",0.967],["XP_004997060.1","XP_004992553.1",0.933],["XP_004997060.1","XP_004993458.1",0.901],["XP_004997060.1","XP_004995582.1",0.949],["XP_004997060.1","XP_004995970.1",0.939],["XP_004997060.1","XP_004997647.1",0.698],["XP_004997060.1","XP_004998595.1",0.937],["XP_004992553.1","XP_004992462.1",0.935],["XP_004992553.1","XP_004998595.1",0.862],["XP_004992553.1","XP_004997647.1",0.921],["XP_004992553.1","XP_004995970.1",0.956],["XP_004992553.1","XP_004995582.1",0.931],["XP_004992553.1","XP_004993458.1",0.838],["XP_004998595.1","XP_004992462.1",0.833],["XP_004998595.1","XP_004993458.1",0.778],["XP_004998595.1","XP_004995582.1",0.772],["XP_004998595.1","XP_004995970.1",0.889],["XP_004998595.1","XP_004997647.1",0.891],["XP_004993458.1","XP_004992462.1",0.752],["XP_004993458.1","XP_004995582.1",0.898],["XP_004993458.1","XP_004995970.1",0.9],["XP_004993458.1","XP_004997647.1",0.81],["XP_004995970.1","XP_004992462.1",0.917],["XP_004995970.1","XP_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