{"hash":"10509716039021664","title":"Adaptive immune regulation and antibody isotype switching","description":"These proteins cluster around immune signal modulation: negative regulation of T cell proliferation, IL-4 production, and type 2 immune responses, along with regulation of canonical NF-kappaB signaling and protein ubiquitination, plus regulation of IgG and IgE isotype switching and vacuolar transport. The common theme is regulation of adaptive immunity, especially T/B cell\u2013mediated responses and antibody class switching.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"XP_004993345.1","go_terms":["GO:0042130","GO:0048302","GO:0032410","GO:0002829","GO:0030001","GO:0051224","GO:0002761","GO:0050728","GO:0007034","GO:0048294","GO:0032713","GO:0045619","GO:0031398","GO:0043123"]},{"accession":"XP_004997396.1","go_terms":["GO:0030968"]},{"accession":"XP_004988780.1","go_terms":["GO:0051123","GO:0043923","GO:1900370","GO:1901092","GO:0006367"]},{"accession":"XP_004992914.1","go_terms":["GO:0000492","GO:0048254","GO:0006338","GO:0031063"]},{"accession":"XP_004996451.1","go_terms":[]},{"accession":"XP_004996520.1","go_terms":[]},{"accession":"XP_004997246.1","go_terms":["GO:1903351","GO:0035751","GO:0016336","GO:0071169","GO:0034130","GO:1903125","GO:0045842","GO:2000172","GO:1904887","GO:0070340","GO:1902499","GO:0060161","GO:0051014","GO:1905289","GO:0014041","GO:0022028","GO:0035564","GO:0002755","GO:0071287","GO:0090394","GO:1903215","GO:1905279","GO:0016567"]},{"accession":"XP_004989582.1","go_terms":[]}],"graph":[["XP_004993345.1","XP_004996520.1",0.529]],"all_go_terms":{"GO:0051224":1,"GO:0002761":1,"GO:0007034":1,"GO:0042130":1,"GO:0043123":1,"GO:0002829":1,"GO:0031398":1,"GO:0048302":1,"GO:0032713":1,"GO:0048294":1,"GO:0045619":1,"GO:0050728":1,"GO:0030001":1,"GO:0032410":1,"GO:0030968":1,"GO:1900370":1,"GO:0043923":1,"GO:0051123":1,"GO:0006367":1,"GO:1901092":1,"GO:0000492":1,"GO:0006338":1,"GO:0031063":1,"GO:0048254":1,"GO:0016336":1,"GO:0035751":1,"GO:0051014":1,"GO:1905289":1,"GO:1903351":1,"GO:0060161":1,"GO:1903125":1,"GO:0045842":1,"GO:2000172":1,"GO:0022028":1,"GO:0002755":1,"GO:0071287":1,"GO:0035564":1,"GO:1904887":1,"GO:0070340":1,"GO:0034130":1,"GO:1905279":1,"GO:1903215":1,"GO:0016567":1,"GO:0071169":1,"GO:1902499":1,"GO:0014041":1,"GO:0090394":1},"recipe_readded":["XP_004994616.1","XP_004996068.1","XP_004996185.1","XP_004993241.1","XP_004998821.1","XP_004992152.1","XP_004990830.1","XP_004990570.1","XP_004997872.1","XP_004989692.1","XP_004994740.1","XP_004993106.1","XP_004987743.1","XP_004990995.1","XP_004991685.1","XP_004994991.1","XP_004991070.1","XP_004993307.1","XP_004991462.1","XP_004987481.1"]}