{"hash":"927166911244712649","title":"p53-Mediated DNA Damage Response and Proteostasis","description":"The GO terms cluster around p53 signaling and cell cycle regulation (including positive regulation of p53 mediator signaling and regulation of the cell cycle), with evidence of proteostasis control (protein stabilization and negative regulation of ubiquitin-dependent proteolysis/ubiquitin ligase activity) and a stress response to DNA-damaging agents like actinomycin D; translation-related terms may reflect a broader stress-associated translational regulation, together suggesting a cohesive response to DNA damage requiring cell cycle control and proteostasis.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"members":[{"accession":"XP_019330621.1","go_terms":["GO:0000462","GO:0006412"]},{"accession":"XP_710513.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"XP_019331007.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]}],"graph":[["XP_019330621.1","XP_019331007.1",0.786],["XP_019330621.1","XP_710513.1",0.599]],"all_go_terms":{"GO:0006412":3,"GO:0000462":1,"GO:0050821":2,"GO:0071157":2,"GO:1904667":2,"GO:2000059":2,"GO:0032986":2,"GO:0072717":2,"GO:1901798":2,"GO:0071158":2},"recipe_readded":[]}