{"hash":"15553037889919721","title":"Membrane Proteolysis and NFAT Signaling Modulation","description":"Top GO terms suggest membrane protein proteolysis (ectodomain and intracellular domain) and retrograde transport, paired with regulation of immune response and positive regulation of the calcineurin-NFAT signaling cascade. This points to a cohesive theme where proteolytic processing of membrane proteins influences NFAT-related signaling and immune regulatory processes, though the exact proteins and pathways are diverse. Confidence in this label is intermediate because while there is a clear proteolysis and NFAT signal, other terms (fibrinolysis, tubule cavitation) add complexity.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"members":[{"accession":"XP_003367136.1","go_terms":["GO:0050776","GO:1904211","GO:0051533","GO:0006509","GO:0070886","GO:0031293"]},{"accession":"XP_003379672.1","go_terms":["GO:1902042","GO:0007596","GO:0090201","GO:0048771","GO:0003383","GO:0045445","GO:0051450","GO:0052182","GO:0031639","GO:1901299","GO:0016476","GO:0022617","GO:0051918","GO:0051919","GO:0033601","GO:0060707","GO:1903133","GO:0007155","GO:0060665","GO:0060763","GO:0048012","GO:0042730","GO:0033137","GO:0071674","GO:0032715","GO:1902947","GO:0035729","GO:1900744","GO:0010758","GO:0032733","GO:0048544"]},{"accession":"XP_003381162.1","go_terms":["GO:0051390","GO:0090136","GO:0001945","GO:0035545"]},{"accession":"XP_003381341.1","go_terms":[]}],"graph":[["XP_003379672.1","XP_003367136.1",0.738],["XP_003381341.1","XP_003367136.1",0.538],["XP_003367136.1","XP_003381162.1",0.508]],"all_go_terms":{"GO:0070886":1,"GO:1904211":1,"GO:0050776":1,"GO:0031293":1,"GO:0051533":1,"GO:0006509":1,"GO:0060707":1,"GO:1902042":1,"GO:1903133":1,"GO:0051919":1,"GO:0071674":1,"GO:0045445":1,"GO:0010758":1,"GO:0048012":1,"GO:0032733":1,"GO:0048544":1,"GO:0016476":1,"GO:0060763":1,"GO:0032715":1,"GO:0033137":1,"GO:1902947":1,"GO:0003383":1,"GO:0042730":1,"GO:1900744":1,"GO:0052182":1,"GO:0007155":1,"GO:0051918":1,"GO:0060665":1,"GO:0035729":1,"GO:1901299":1,"GO:0033601":1,"GO:0051450":1,"GO:0031639":1,"GO:0007596":1,"GO:0090201":1,"GO:0048771":1,"GO:0022617":1,"GO:0051390":1,"GO:0090136":1,"GO:0035545":1,"GO:0001945":1},"recipe_readded":[]}