[{"hash":"1654273808378462955","title":"Vertebrate organogenesis","description":"Top terms point to development of diverse vertebrate organs (endocrine pancreas, pituitary, retina, neural crest\u2013driven processes, ureteric bud branching, osteoblasts) and embryonic digestive tract morphogenesis, along with transcriptional regulation by RNA polymerase II. The shared theme is embryonic organogenesis and tissue morphogenesis with a transcriptional control layer, suggesting these proteins participate in developmental gene regulation across multiple organs.","confidence":"High","size":29,"edges":125,"triangles":223,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0031018","count":9},{"id":"GO:0006366","count":9},{"id":"GO:0021983","count":8},{"id":"GO:0002076","count":8}]},{"hash":"104831474140815210","title":"Skeletal and connective tissue development","description":"The cluster features GO terms tied to extracellular matrix remodeling (collagen catabolic process, cell adhesion, plasminogen activation), bone mineralization, and skeletal muscle growth, which together point to connective tissue and skeletal development. Some terms (transcription regulation, GTPase regulation) may reflect broader regulatory roles in development, but the dominant theme is skeletal/connective tissue remodeling and formation.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0034260","count":2}]},{"hash":"377247044551552044","title":"Mitosis and Cell Cycle Regulation","description":"This cluster is dominated by GO terms tied to mitosis and cell division (mitotic cell cycle, cell division, mitotic spindle assembly) and APC/C-dependent catabolic processes, plus signals for serine/threonine kinase activity that drive cell-cycle progression. While there are some developmental and stress-response terms, the strongest and most coherent theme is mitotic control and cytoskeletal reorganization during division.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0007338","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0000278","count":4}]},{"hash":"538333730098853698","title":"Mitotic cell cycle and spindle assembly","description":"This cluster is dominated by GO terms for mitosis, cell division, and spindle assembly, indicating a shared function in mitotic progression. Additional signals for kinase and GTPase regulation and mRNA transport suggest regulatory coordination of cell-cycle events, though the core theme remains mitotic control.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":7},{"id":"GO:0071456","count":7},{"id":"GO:0051301","count":6},{"id":"GO:0071902","count":6},{"id":"GO:0043547","count":6}]},{"hash":"619582809374851405","title":"Unknown","description":"The Top Terms are highly diverse (transcription, ubiquitin-mediated degradation, chlorophyll biosynthesis, stamen formation, immunoglobulin isotype switching, morphogenesis, mitotic spindle assembly, inflammatory cytokine production), spanning plant, animal development, immunity, and cell cycle. There are no shared functional themes or interactions (Edges and Triangles are zero), so a cohesive, specific label isn\u2019t supported. None","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006511","count":2},{"id":"GO:0015995","count":2},{"id":"GO:0048455","count":2},{"id":"GO:0043248","count":2}]},{"hash":"1008825817258961599","title":"Chromatin, Transcription, and Translation Regulation","description":"The top GO terms point to chromatin state (subtelomeric heterochromatin formation), transcription (DNA-templated transcription), RNA- and protein-level regulation (regulatory ncRNA-mediated silencing, translational initiation, ubiquitin-proteasome\u2013dependent degradation), plus context in development and innate immunity. This suggests a cluster centered on multi-layer control of gene expression\u2014from chromatin to translation\u2014rather than a single narrow function. Confidence: Medium","confidence":"","size":29,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":2},{"id":"GO:0016246","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0045087","count":2}]},{"hash":"1269732702962007590","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030216","count":3},{"id":"GO:0070121","count":2},{"id":"GO:0019068","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0051893","count":2}]},{"hash":"1758568358403835160","title":"ER-Golgi Vesicle Trafficking","description":"The cluster shows strong representation for ER-to-Golgi and retrograde vesicle transport between the ER and Golgi, suggesting a core function in vesicle trafficking; other terms like ribosome biogenesis and transcription appear but are less central to the dominant signal. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0043982","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0043981","count":3}]},{"hash":"2117951558883576795","title":"Ribosome Biogenesis and DNA Replication Core","description":"The top GO terms point to nucleolar processes (ribosome biogenesis, rRNA maturation) and essential cell-cycle activities (DNA replication, mitotic cell cycle, DNA-templated transcription), suggesting a cluster of core nucleolar and replication machinery. Some developmental terms may be incidental annotations, but the dominant theme ties to ribosome assembly and cell division.","confidence":"High","size":29,"edges":20,"triangles":0,"max_degree":20,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0006260","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0000463","count":4}]},{"hash":"1071093273154567411","title":"RNA Methylation and Cap Formation","description":"This cluster shows strong enrichment for RNA modification processes: guanine-N7 methylation, 7-methylguanosine mRNA capping, and tRNA wobble uridine modification, plus peptidyl-arginine methylation, all pointing to RNA methyltransferase/capping functions as the core theme. Some other terms like xenobiotic response or nodulation may reflect broader stress or metabolic contexts, but the dominant pattern is RNA methylation and RNA processing.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":7},{"id":"GO:0017000","count":6},{"id":"GO:0019919","count":6},{"id":"GO:0002098","count":6},{"id":"GO:0036265","count":6}]},{"hash":"164741233416136412","title":"Tissue development and cell adhesion","description":"Top GO terms emphasize tissue morphogenesis (lung and cartilage development, trophoblast differentiation) and cell adhesion, suggesting these proteins contribute to tissue formation and intercellular interactions. Additional terms indicate regulatory signaling (NF-kappaB pathway) and mechanical responsiveness common in developmental contexts, while a few annotations may be broad or cross-species. Overall, the cluster likely represents genes involved in tissue development and cell adhesion.","confidence":"Medium","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":3},{"id":"GO:0060707","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0051918","count":2},{"id":"GO:0010754","count":2}]},{"hash":"2041094600230702863","title":"Unknown","description":"The proteins are linked to a broad mix of processes\u2014cell cycle regulation (G1/S transition, DNA replication initiation, centrosome separation), ER-stress\u2013related apoptosis, and diverse developmental events (mammary gland branching, ovulation, osteoclast fusion, dendrite development). The lack of a single, cohesive theme and minimal connectivity make it hard to assign a specific functional label beyond Unknown.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":2},{"id":"GO:0000082","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0060444","count":1},{"id":"GO:0022407","count":1}]},{"hash":"2004809772342774774","title":"Neural development and transcription regulation","description":"The terms are dominated by brain and multicellular development (brain development, forebrain development, skeletal system development, multicellular organism development) along with a notable enrichment for DNA-templated transcription, hinting at transcriptional regulation during neural development. A few outliers (defense response to Gram-positive bacteria, cadmium/stress responses, nuclear pore localization) are present but do not dominate, so the overall theme centers on developmental and neural gene regulation rather than a single, cohesive pathway.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007420","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0007568","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0030900","count":5}]},{"hash":"852244476372747755","title":"Embryonic development and sensory system formation","description":"The cluster is enriched with developmental and sensory-related GO terms, including multicellular organism development, embryonic cranial skeleton morphogenesis, inner ear development, placenta development, and visual/pain perception. There are also signals of DNA replication and mitotic checkpoint activity, which can accompany proliferative phases in development, and a few immune/chemical-response terms that are less central. Overall, the dominant theme points to embryonic development and sensory system formation, supporting this label.","confidence":"Medium","size":28,"edges":31,"triangles":26,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":12},{"id":"GO:0007275","count":12},{"id":"GO:0042220","count":11},{"id":"GO:0048839","count":11},{"id":"GO:0007601","count":11}]},{"hash":"448540760684855426","title":"RNA Splicing and Transcription Regulation","description":"This cluster is dominated by RNA processing terms (RNA splicing and spliceosome regulation) and negative regulation of transcription by RNA polymerase II, suggesting a core function in RNA processing and gene expression control, with additional, related developmental and signaling terms likely reflecting broader regulatory roles.","confidence":"Medium","size":28,"edges":18,"triangles":1,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:0008380","count":2},{"id":"GO:1900025","count":2},{"id":"GO:0045880","count":2},{"id":"GO:0007338","count":2}]},{"hash":"1949569584507335358","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":12,"triangles":1,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0000480","count":3},{"id":"GO:0048568","count":3}]},{"hash":"1539830020219103472","title":"mRNA Processing and Translation Regulation","description":"The cluster is dominated by GO terms for mRNA splicing and spliceosome activity, mRNA modification, and splice-site recognition, plus translation initiation/reinitiation and stress-related mRNA stability, with even notes of regulatory ncRNA silencing. This combination indicates a cohesive module of RNA processing and translational control, rather than a single metabolic pathway.","confidence":"High","size":28,"edges":15,"triangles":0,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":6},{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0010610","count":5}]},{"hash":"649436938005502384","title":"Neural development and signaling regulation","description":"The terms point to neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration) and signaling regulation (insulin receptor/ERK pathways), with an additional note on pain perception and T cell signaling. Overall, the cluster appears to group proteins involved in neural development and modulation of key intracellular signaling cascades, with some peripheral immune terms likely reflective of broader signaling roles.","confidence":"Medium","size":28,"edges":87,"triangles":182,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":11},{"id":"GO:0050852","count":11},{"id":"GO:0008285","count":11},{"id":"GO:0048679","count":11},{"id":"GO:0021697","count":11}]},{"hash":"1221889293331553536","title":"Nuclear Gene Expression and Telomere Maintenance","description":"Top GO terms indicate core nuclear processes including DNA-templated transcription, DNA replication, and mRNA processing, along with regulation of nuclear export and telomere maintenance (telomere capping and telomerase). While proliferation and migration terms appear, the dominant signal is nuclear genome expression and telomere maintenance, supporting this label.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0006260","count":5},{"id":"GO:0046826","count":5},{"id":"GO:0006397","count":5},{"id":"GO:0055114","count":5}]},{"hash":"1974389744340824814","title":"Heat-Responsive Signaling and Proliferation in Neural and Vascular Cells","description":"The top GO terms point to heat response and intracellular signaling, with neural differentiation (cerebellar granule cells) and endothelial cell proliferation (angiogenesis) also prominent, along with cell growth and spindle assembly. This pattern suggests a cohesive theme of stress-activated signaling that regulates proliferation and differentiation across neural and vascular contexts.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0035556","count":4},{"id":"GO:0021707","count":4},{"id":"GO:0045736","count":4},{"id":"GO:0070427","count":3}]},{"hash":"1171137032329335500","title":"Actin Cytoskeleton Remodeling and Endocytosis Regulators","description":"The GO terms point to strong enrichment for actin-related processes (cortex patch assembly, Arp2/3 regulation, actin cytoskeleton organization) and endocytosis, with involvement in Rho signaling and JNK cascade regulation. This suggests the cluster is centered on proteins that coordinate actin dynamics and endocytic trafficking, potentially modulated by signaling pathways. DNA replication/integration terms are present but appear less representative of the main theme. Overall, the dominant signal is cytoskeletal remodeling and endocytosis control.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0000147","count":2},{"id":"GO:0034316","count":2},{"id":"GO:0006897","count":2}]},{"hash":"777102953724798126","title":"Neurodevelopmental transcriptional regulation","description":"The cluster prominently features GO terms tied to neural development (forebrain development, neural tube closure) and DNA-templated transcription, suggesting proteins involved in regulating gene expression during neurodevelopment. While some terms (cadmium response, proteasomal degradation, immune-related) are present, they appear peripheral to the core neurodevelopmental theme. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071276","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0007338","count":2}]},{"hash":"1192136430762380281","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitin-mediated proteolysis, including ubiquitin-dependent protein catabolic process, SCF-dependent proteasomal ubiquitin-dependent catabolic process, and protein polyubiquitination. This points to a coherent proteostasis module centered on tagging substrates for degradation. A circadian regulation term appears but is secondary; overall the cluster is best described by ubiquitin-proteasome\u2013driven protein turnover.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0042752","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0000209","count":4},{"id":"GO:0000083","count":4}]},{"hash":"199891984962248980","title":"Male gonad development and transcriptional regulation","description":"The top GO terms point to Sertoli cell development and positive regulation of male gonad development, indicating a core involvement in testis formation. Coupled with terms for transcriptional control and chromatin remodeling, plus basic cellular processes like translation and DNA replication, the cluster seems to represent genes coordinating gonadal development with gene-expression programs. Confidence: High","confidence":"","size":28,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0001666","count":2},{"id":"GO:0060009","count":2},{"id":"GO:0000122","count":2},{"id":"GO:2000020","count":2}]},{"hash":"1126200138658763286","title":"Potassium Transport and Membrane Potential Regulation","description":"This cluster's top GO terms cluster around potassium ion transport and membrane potential maintenance (intracellular potassium homeostasis, stabilization and regulation of membrane potential, and cardiac muscle repolarization), suggesting proteins that regulate potassium balance and electrical excitability across membranes, with mechanosensation terms possibly reflecting mechanosensitive channels.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0071805","count":7},{"id":"GO:0050976","count":7},{"id":"GO:0030007","count":7},{"id":"GO:0030322","count":7},{"id":"GO:0098914","count":7}]},{"hash":"810076444749347712","title":"Angiogenesis, coagulation, and Toll-mediated immunity","description":"The top GO terms cluster around vascular-related processes (angiogenesis, blood coagulation) and innate immune signaling (Toll pathway, defense against Gram-positive bacteria). These appear as the strongest signals, suggesting a functional group involved in vascular-immune interactions, with some auxiliary terms like glucose response and midbrain development likely less central. Confidence: Medium","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":6},{"id":"GO:0045766","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0000122","count":6}]},{"hash":"479370077453228893","title":"Junction Assembly and Barrier Regulation","description":"The top GO terms cluster around cell junctions and barrier formation, including localization to adherens junctions, tight junction assembly, endothelial barrier establishment, and myelin sheath regions, suggesting a core theme of tissue integrity. Additional terms point to related signaling (JNK, p38MAPK) and centrosome localization, implying broader roles in cell polarity and organization. A few outliers (grooming behavior, osteoclast development) are less aligned but do not override the junction/barrier focus. Confidence: Medium","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000821","count":3},{"id":"GO:0071896","count":3},{"id":"GO:0035750","count":3},{"id":"GO:2001205","count":3},{"id":"GO:1903286","count":3}]},{"hash":"883786019752839991","title":"Neural and Skeletal Development with Proliferation","description":"Most of the top GO terms describe developmental processes for nervous system tissues (retina development, neural tube closure, neuron projection development) and skeletal system development, with several entries noting positive regulation of cell population proliferation. This points to a coordinated developmental program spanning neural and skeletal tissues, with proliferative regulation, rather than a single specific pathway. A few terms (cadmium ion response) reflect stress responses that are less central to the cluster's core theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1619835134909250069","title":"Cranial nerve and ganglia development","description":"The top GO terms cluster around development and guidance of cranial nerves and their ganglia (facial nerve organization, facioacoustic and trigeminal ganglia development, sympathetic neuron guidance, axon extension/guidance, and related signaling). This suggests a coherent theme of cranial nerve formation and neural connectivity driven by axon guidance processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021612","count":2},{"id":"GO:0097491","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0045880","count":2},{"id":"GO:0097374","count":2}]},{"hash":"322559569762228893","title":"Retroelement Mobilization and Proviral Integration","description":"The top GO terms cluster around movement and integration of foreign genetic material: DNA integration, retrotransposition, RNA-templated DNA biosynthetic process, proviral latency, and viral entry into the nucleus. These point to retroelement activity and proviral genome integration as the central theme, with related processes like DNA replication and RNAi regulation interacting in this context; some \u201csymbiont\u201d terms may reflect host\u2013pathogen-like interactions but do not override the retroelement/proviral signal.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0070301","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0006278","count":2}]},{"hash":"778513029704235424","title":"Ribosome biogenesis and translation initiation","description":"This cluster is dominated by GO terms for ribosome biogenesis, rRNA maturation, and formation of translation preinitiation complexes, plus translation reinitiation and related mRNA processing, pointing to a core module of ribosome assembly and protein synthesis with associated growth signals.","confidence":"High","size":27,"edges":8,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0008283","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0042254","count":5},{"id":"GO:0000462","count":5}]},{"hash":"1674687819049124104","title":"Lymphocyte actin remodeling and signaling","description":"This cluster is dominated by actin cytoskeleton dynamics (lamellipodium and filopodium assembly) and small GTPase signaling (Rac, Ras), which point to actin-driven cell migration in immune cells. The presence of B cell receptor signaling and interleukin-related responses (IL-4 production, response to IL-7) supports an immune signaling context. Heart development appears incidental rather than defining the core function. Overall, the proteins seem to coordinate cytoskeletal remodeling during immune signaling and migration.","confidence":"High","size":27,"edges":17,"triangles":0,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0032633","count":8},{"id":"GO:0035020","count":8},{"id":"GO:0030032","count":8},{"id":"GO:0046580","count":8}]},{"hash":"1244499267866374753","title":"Transcription Regulation and Gene Silencing","description":"Most of the top GO terms point to control of gene expression, especially transcriptional regulation (regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II) and regulatory ncRNA\u2013mediated gene silencing. Other terms (lung development, T cell homeostasis, axon extension, mechanosensation) appear as secondary annotations, but the core signal centers on transcriptional control.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0098914","count":3}]},{"hash":"305727774411029693","title":"Telomeric and rDNA heterochromatin regulation","description":"The GO terms center on heterochromatin formation and regulation at rDNA repeats and subtelomeric/telomeric regions, including silent mating-type cassette silencing and chromatin maintenance. This points to a cluster of chromatin modifiers and regulators governing heterochromatin formation and gene silencing at these repetitive chromosomal loci.","confidence":"High","size":27,"edges":33,"triangles":12,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000183","count":5},{"id":"GO:0070933","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0061188","count":4},{"id":"GO:0006351","count":4}]},{"hash":"355647513227001756","title":"Retroviral DNA integration and latency","description":"This cluster is dominated by GO terms related to viral genome dynamics: DNA replication and recombination, DNA integration, RNA-templated DNA synthesis (reverse transcription), and establishment of integrated proviral latency, plus viral entry/penetration into the host nucleus and symbiont-mediated host interactions. Collectively, these point to retroviral replication cycles and virus-host genome integration with associated host manipulation, rather than a housekeeping cellular process. The presence of negative regulation of siRNA processing aligns with viral suppression of host RNAi defenses. Confidence: High","confidence":"","size":27,"edges":25,"triangles":0,"max_degree":25,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0006310","count":8},{"id":"GO:0075713","count":7},{"id":"GO:0015074","count":7},{"id":"GO:0006278","count":6}]},{"hash":"913142338702491539","title":"Axon Guidance and Synapse Assembly","description":"Based on the top GO terms, the cluster centers on neural development processes such as axon guidance (including corticospinal neuron guidance) and synapse assembly, with supporting ECM remodeling and mechanosensing signals. While inflammatory and hormonal response terms appear, the dominant pattern points to neuronal growth and connectivity.","confidence":"High","size":27,"edges":27,"triangles":2,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":10},{"id":"GO:0071260","count":9},{"id":"GO:0030199","count":9},{"id":"GO:0048846","count":8},{"id":"GO:0050929","count":8}]},{"hash":"1699815063349552588","title":"Rho-regulated actin remodeling and cell motility","description":"This cluster centers on actin cytoskeleton dynamics, with terms for Rho-mediated signaling, lamellipodium and filopodium assembly, and actin organization, all pointing to coordinated actin remodeling and cellular movement/polarity. While some terms touch on development or neural functions, the shared theme is actin-driven motility and structural organization guided by Rho pathways.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0030032","count":3},{"id":"GO:0051660","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0090557","count":3}]},{"hash":"1479509388994300911","title":"RNAi and miRNA silencing pathways","description":"The cluster is enriched for RNA interference and miRNA-related processes: siRNA-mediated gene silencing, pre-miRNA processing, and co-transcriptional gene silencing by RNA interference machinery, with additional hints of regulatory ncRNA\u2013mediated heterochromatin formation and miRNA-mediated silencing regulation. While a couple of terms like translational initiation and intracellular transport appear, the dominant pattern centers on RNA silencing and miRNA biogenesis, suggesting a cohesive functional module in RNA-based regulation.","confidence":"Medium","size":27,"edges":7,"triangles":0,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006413","count":4},{"id":"GO:0048015","count":4},{"id":"GO:0006886","count":4},{"id":"GO:0090625","count":3},{"id":"GO:0070924","count":3}]},{"hash":"1209320141259697541","title":"Chemokine-driven immune cell recruitment","description":"Based on the top GO terms, several entries center on chemokine production and leukocyte chemotaxis (e.g., interleukin-8, CXCL2, macrophage recruitment). Although there are some additional processes (translation, vascular permeability, bone remodeling), the strongest common theme is inflammatory signaling guiding immune cell movement, suggesting this cluster reflects chemokine- and immune-driven recruitment.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0007218","count":1},{"id":"GO:2000484","count":1},{"id":"GO:1904155","count":1},{"id":"GO:0035926","count":1}]},{"hash":"2284393604783019802","title":"Unknown","description":"The GO terms are highly diverse, spanning ribosome biogenesis (two rRNA maturation terms) and numerous developmental and stress-related processes with no clear shared function across the majority of proteins. The lack of network connectivity (Edges 0, Triangles 0) further suggests there is no cohesive theme to label a specific function beyond an unknown grouping.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018107","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0071276","count":2}]},{"hash":"282183377007467834","title":"Spliceosome and mitotic spindle components","description":"This cluster includes GO terms for mRNA splicing via the spliceosome and for mitotic/spindle-related processes (centrosome duplication, spindle orientation) plus microtubule-associated vesicle transport and cortex development terms, suggesting a theme of RNA processing connected to microtubule-driven cell division and neural development contexts.","confidence":"Medium","size":27,"edges":12,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0000245","count":2},{"id":"GO:0007100","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0021987","count":1}]},{"hash":"1132986983768981054","title":"Cell signaling and locomotion","description":"The top GO terms span immune cell migration (neutrophil chemotaxis, T cell activation), adhesion and cytoskeletal dynamics (integrin signaling, filopodium assembly, substrate adhesion-dependent spreading), and various signaling processes (synaptic vesicle exocytosis, insulin response, brown fat differentiation). While diverse contexts are present (immune, neuronal, metabolic), they share a common theme of cell signaling that governs movement, adhesion, and communication, justifying a label around cell signaling and locomotion.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0050873","count":2},{"id":"GO:0016032","count":2}]},{"hash":"901635427045177155","title":"Fungal signaling, mating, and cytoskeletal dynamics","description":"These proteins show enrichment for signaling-related GO terms (positive regulation of kinase and GTPase activities), cytoskeletal organization (actin crosslinking; terminal web assembly), and developmental processes (ascospore formation; karyogamy; mitotic cell cycle). The combination points to a cluster of factors coordinating signaling, mating-related development, and cytoskeletal remodeling in fungi.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071902","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0031954","count":3}]},{"hash":"2242887279369750214","title":"DNA Integration and Chromatin Modification","description":"This cluster\u2019s strongest signals are DNA replication, DNA integration, and proviral latency establishment, along with histone H3-K79 methylation, all pointing to genome maintenance and chromatin regulation. Secondary terms include metabolic processes and vesicle transport, which may reflect broader or divergent annotations but do not define the main theme. Overall, the shared thread appears to be nucleic acid processing and chromatin state management, sometimes linked to viral genome integration contexts.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0019252","count":2},{"id":"GO:0005978","count":2}]},{"hash":"48046398223090859","title":"Eye and Retina Development","description":"Based on the top GO terms, the cluster centers on eye/retina formation and function, including retina development, embryonic eye development, photoreceptor maintenance, and light-detection for visual perception, with supporting neural patterning and ganglion development terms. The overall theme is ocular development and vision, so the label reflects the shared biology.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0051567","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0061548","count":1},{"id":"GO:0060831","count":1}]},{"hash":"2212230814842059081","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":1},{"id":"GO:0009395","count":1},{"id":"GO:0070292","count":1},{"id":"GO:0072684","count":1},{"id":"GO:1903999","count":1}]},{"hash":"1661393876048031668","title":"Multisystem Development and Transcription Regulation","description":"The cluster shows strong signals for development and differentiation across multiple tissues (pancreas, muscle, nervous system, lung, bone, mast cells) along with transcription-related activity (RNA polymerase II). This pattern suggests a general role in coordinating developmental processes and gene regulation across diverse tissues, rather than a single tissue-specific function.","confidence":"Medium","size":26,"edges":319,"triangles":2465,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":20},{"id":"GO:0045668","count":20},{"id":"GO:0031018","count":15},{"id":"GO:0035914","count":15},{"id":"GO:0006366","count":14}]},{"hash":"2190261988703706583","title":"RNA splicing and gene expression regulation","description":"The cluster is dominated by mRNA splicing and spliceosome-related processes (splicing, splice site recognition, via spliceosome), along with mRNA modification and regulation of translational initiation, plus regulatory ncRNA-mediated gene silencing. This set points to a coherent theme of RNA processing and post-transcriptional regulation of gene expression, with a developmental term suggesting broader regulatory roles. ","confidence":"Medium","size":26,"edges":33,"triangles":9,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":4},{"id":"GO:0048026","count":3},{"id":"GO:0042766","count":2},{"id":"GO:0006265","count":2},{"id":"GO:0048701","count":2}]},{"hash":"1665259131805045955","title":"mRNA Splicing, Export, and Translation Initiation","description":"The top GO terms cluster around mRNA processing and post-transcriptional regulation: spliceosome-mediated splicing, splice site recognition, mRNA modification, export from the nucleus, and ribosomal biogenesis, alongside translation initiation and reinitiation, and regulatory ncRNA-mediated gene silencing. This suggests a cohesive cluster linking spliceosomal processing with subsequent translation control.","confidence":"High","size":26,"edges":33,"triangles":15,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0006406","count":5},{"id":"GO:0006378","count":5}]},{"hash":"485556815238932715","title":"Immune regulation and inflammatory signaling","description":"The cluster\u2019s GO terms are dominated by negative regulation of immune processes (mast cell degranulation, IL-2 production, germinal center formation, chronic inflammatory response) and T cell differentiation, with additional terms related to tissue remodeling (smooth muscle development, vascular wound healing). This pattern points to proteins that modulate immune responses and inflammatory pathways, occasionally linked to remodeling of tissues during inflammation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043305","count":2},{"id":"GO:0045085","count":2},{"id":"GO:0048745","count":2},{"id":"GO:0061470","count":2},{"id":"GO:0002635","count":2}]},{"hash":"880557935744295446","title":"Retroviral DNA integration and latency","description":"The top terms center on DNA integration, proviral latency, and entry/penetration of the host nucleus, which are hallmark steps of the retroviral life cycle. Additional terms like DNA replication, DNA recombination, and RNA-templated DNA biosynthesis align with reverse transcription and genome integration. The presence of negative regulation of siRNA processing and host apoptosis activation suggests viral strategies to evade host defenses and influence host cell fate. Collectively, these terms indicate a cohesive theme around retroviral integration and latency within host cells.","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0046718","count":7},{"id":"GO:0075713","count":7},{"id":"GO:0075732","count":7},{"id":"GO:0039651","count":7}]},{"hash":"2125279401107120664","title":"Vesicle trafficking and membrane fusion","description":"The GO terms cluster around intracellular transport of proteins via vesicles, endocytosis, vesicle fusion, and membrane remodeling (including MVB sorting and membrane repair). The inclusion of brain development and acrosome reaction points to vesicle-driven secretion and exocytosis in neurons and reproductive cells. Overall, the common theme is vesicle trafficking and membrane dynamics across contexts.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0048260","count":2},{"id":"GO:0030948","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0001778","count":2}]},{"hash":"360181760314449035","title":"Unknown","description":"Top terms are very heterogeneous, including transcriptional activity, RNA silencing, mRNA transport, nuclear pore complex assembly, chromatin modification, actin nucleation signaling, development, photoreception, mitotic cohesion, and DNA repair. With no cohesive function uniting these terms and no edges linking members, there is no clear shared function to label this cluster beyond Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0016246","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0051292","count":2},{"id":"GO:2000601","count":2}]},{"hash":"307998714764742846","title":"Filopodium Formation and Actin Remodeling","description":"The top GO terms repeatedly point to filopodium assembly/regulation and actin cytoskeleton remodeling, with links to fibroblast migration and endosome localization. This suggests the proteins cluster around cytoskeletal dynamics and protrusion formation rather than a single signaling pathway; other terms appear more peripheral. Overall, the theme is actin-driven filopodium dynamics and cell movement.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:0036010","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0032966","count":2},{"id":"GO:0051489","count":2}]},{"hash":"1635153930726310427","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning ribosome biogenesis and cell cycle-related processes, but also include sensory perception of sound and DNA integration, with no clear unifying function for the cluster. The absence of internal edges and a cohesive theme supports labeling as Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045725","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0015074","count":2},{"id":"GO:1901001","count":1},{"id":"GO:0007049","count":1}]},{"hash":"2139571130467380274","title":"PDGF-Responsive Integrin Signaling and ECM Remodeling","description":"The cluster is driven by terms for integrin-mediated signaling, receptor clustering, PDGF stimulus response, and fibroblast migration, with plasminogen activation pointing to extracellular matrix remodeling and adhesion dynamics. Negative regulation of anoikis and pericardium morphogenesis emphasize survival and tissue development within an ECM context. Together, these suggest a cohesive function in cell adhesion, ECM remodeling, and migration.","confidence":"High","size":25,"edges":29,"triangles":7,"max_degree":8,"top_function":"wound healing","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0031639","count":5},{"id":"GO:0003344","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0098869","count":4}]},{"hash":"791870049655090489","title":"Developmental signaling and morphogenesis","description":"This cluster centers on developmental signaling and patterning, as shown by GO terms for JNK cascade regulation, canonical Wnt signaling, and GTPase activity regulation, alongside apoptosis. Additional terms relate to tissue development and morphogenesis (neuron development, mammary gland branching, uterus development) and cell-cell adhesion, suggesting proteins coordinating signaling pathways with tissue patterning and morphogenesis rather than a single metabolic function.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0048666","count":2}]},{"hash":"406250518375613584","title":"Neural development and behavior regulation","description":"The top terms cluster around nervous system development (central nervous system morphogenesis), neural-directed behaviors (righting reflex, behavioral response to ethanol), and regulation of gene expression (transcription regulation, spliceosomal assembly), suggesting a function in neural development and neuronal behavior with underlying transcription/splicing control. Some terms (innate immune response, ERAD-related) appear less central or obsolete, so the core theme is neural development and behavior-related gene regulation.","confidence":"Medium","size":25,"edges":5,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:1903070","count":4},{"id":"GO:0060013","count":4},{"id":"GO:0006355","count":4},{"id":"GO:1904378","count":4},{"id":"GO:0055114","count":3}]},{"hash":"867095842366604844","title":"Developmental transcriptional regulators","description":"This cluster is dominated by DNA-templated transcription, with strong associations to tissue development across multiple organs (Leydig cell differentiation, placenta and mammary gland development, chondrocyte growth, in utero embryonic development, vagina development). While a lipopolysaccharide response term appears, the prevailing theme points to transcriptional control of developmental processes, suggesting involvement of transcription factors or co-regulators guiding organogenesis.","confidence":"Medium","size":25,"edges":111,"triangles":234,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":15},{"id":"GO:2001275","count":13},{"id":"GO:0071222","count":11},{"id":"GO:0003430","count":11},{"id":"GO:0033327","count":11}]},{"hash":"495992833527404099","title":"Neural development and cell cycle regulation","description":"The top terms show neural development (cerebral cortex development, Schwann cell development) and synaptic activity (excitatory postsynaptic potential), with Wnt signaling also involved in development. At the same time, cell cycle\u2013related terms (DNA replication, G1/S transition, meiosis, kinetochore localization) point to proliferative neural progenitors or glial precursor dynamics. Together, the cluster likely represents proteins coordinating neural development with cell division and maturation processes.","confidence":"Medium","size":25,"edges":71,"triangles":141,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0060079","count":7},{"id":"GO:0051321","count":7},{"id":"GO:0000082","count":7},{"id":"GO:0042220","count":7}]},{"hash":"2275509702863702684","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0007420","count":5},{"id":"GO:2000601","count":5},{"id":"GO:0051567","count":5}]},{"hash":"2148843524259630803","title":"Spliceosome-Driven mRNA Processing","description":"The cluster is enriched for terms related to splicing (mRNA splicing via spliceosome, splice site recognition), mRNA modification and stability regulation, and regulation of translational initiation, indicating a cohesive group centered on post-transcriptional mRNA processing and translational control.","confidence":"High","size":25,"edges":286,"triangles":2039,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0006378","count":13},{"id":"GO:0000398","count":12},{"id":"GO:0045292","count":11},{"id":"GO:0090503","count":11}]},{"hash":"357844630434270652","title":"Neural signaling and sensory perception","description":"The cluster is enriched for terms tied to neural signaling and sensory processing: dopamine and cocaine responses, visual learning and visual perception, pain perception, and ERK cascade regulation\u2014typical of neuronal signaling pathways. A few developmental terms (heart and skeletal development) appear less directly connected but may reflect broader expression; overall, the dominant theme is neural signaling and sensory processing.","confidence":"Medium","size":25,"edges":21,"triangles":0,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":5},{"id":"GO:0048148","count":4},{"id":"GO:0070374","count":4},{"id":"GO:1903351","count":4},{"id":"GO:0001501","count":4}]},{"hash":"1654363217302478643","title":"Neurodevelopment and vesicle transport","description":"This cluster is enriched for nervous system development, brain development, and smoothly linked developmental signaling (Smoothened pathway), alongside components of the secretory pathway (COPII budding, ER-to-Golgi transport), exocytosis, and junction assembly, indicating a cohesive theme of neural development coordinated with vesicle trafficking. ","confidence":"Medium","size":25,"edges":145,"triangles":253,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0007224","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0090114","count":5}]},{"hash":"1750695023243830727","title":"APC/C- and SCF-driven mitotic proteolysis","description":"The GO terms show strong enrichment for ubiquitin-dependent degradation processes during mitosis (including APC/C- and SCF-mediated catabolism and K11-linked ubiquitination), along with mitotic cell cycle, cell division, spindle checkpoint-related regulation, and chromatin remodeling/DNA repair. This pattern points to a cluster centered on ubiquitin-mediated control of mitotic progression and chromosome maintenance.","confidence":"High","size":25,"edges":153,"triangles":457,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":13},{"id":"GO:0031146","count":11},{"id":"GO:0031145","count":11},{"id":"GO:0070979","count":11},{"id":"GO:0000278","count":11}]},{"hash":"972804964400900398","title":"Developmental Gene Regulation and Stress Responses","description":"The top terms span developmental processes (neural tube closure, multicellular growth, cell migration, DNA-templated transcription) and stress or signaling responses (JNK cascade regulation, response to cadmium, cocaine). Telomere maintenance/capping links to cell proliferation and genome stability. Together, they point to proteins involved in developmental regulation intertwined with cellular stress signaling, rather than a single, narrow pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0035264","count":3},{"id":"GO:0046330","count":3},{"id":"GO:1904355","count":3},{"id":"GO:0042220","count":3}]},{"hash":"489360164882314363","title":"Gametogenesis and transcriptional regulation","description":"This cluster is dominated by GO terms related to germ cell development and nuclear gene regulation, including mitotic cell cycle, DNA-templated transcription, regulation of mRNA poly(A) tail shortening, DNA methylation involved in gamete generation, and spermatid development. These point to a core theme of germ cell formation and transcriptional control, with a few ancillary terms (e.g., heart development, endosome transport) that are less central to the cluster\u2019s primary signal. Overall, the label reflects the most enriched theme across the members. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000335","count":3},{"id":"GO:0060213","count":3},{"id":"GO:0007286","count":3}]},{"hash":"965171509456987741","title":"Ribosome Biogenesis and Cell Cycle","description":"Most frequent GO terms point to ribosome assembly (ribosomal large subunit biogenesis, ribosome biogenesis), cell division and the mitotic cell cycle, and TORC1 signaling, all indicative of growth and protein-synthesis\u2013coupled progression. Actin filament dynamics appear as a supportive cytoskeletal component during division, while an outlier term related to retina development is likely incidental. Overall, the cluster seems to represent core ribosome production and cell-cycle regulation rather than a specialized pathway.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0030042","count":4},{"id":"GO:0038202","count":3},{"id":"GO:0000278","count":3}]},{"hash":"2114644746345737698","title":"Virus entry and host RNA processing","description":"The top GO terms cluster around virus-mediated entry into host cells (virion attachment, fusion with endosome, symbiont entry) alongside core translation and RNA-processing activities (cytoplasmic translation, rRNA maturation, tRNA/rRNA methylation). This suggests proteins co-involved in viral entry and the manipulation or support of host RNA processing/translation machinery. ","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0002003","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0036265","count":2}]},{"hash":"2302977151791466808","title":"Angiogenic signaling and actin cytoskeleton remodeling","description":"This cluster centers on signaling-related processes (dephosphorylation, receptor clustering, transcription-related activity) coupled with cytoskeletal dynamics and trafficking (actin depolymerization regulation, endosome transport) and cell migration in sprouting angiogenesis, suggesting proteins that coordinate signal transduction with cytoskeletal remodeling during angiogenic movement.","confidence":"Medium","size":25,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0016311","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0002042","count":3}]},{"hash":"1949025260079791207","title":"Developmental transcription and signaling","description":"This cluster centers on transcriptional regulation and developmental signaling, with GO terms such as DNA-templated transcription, brain development, and TGF-beta/hypoxia responses. The presence of ER-Golgi transport and actin remodeling suggests cellular remodeling during development, but the terms are diverse and no single pathway ties all proteins together, so the label emphasizes the developmental/transcriptional theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007420","count":4},{"id":"GO:0071560","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0071456","count":3}]},{"hash":"100718228568711643","title":"Glycolysis and Oxidative Stress Response","description":"This cluster's proteins are linked to glycolytic metabolism (glycolytic process) and redox-related responses (oxidation\u2013reduction, response to hydrogen peroxide, hypoxia), suggesting a theme of energy production coupled with oxidative stress adaptation. Obsolete GO terms and a plant-specific term (photorespiration) are present but do not override the main metabolic signal.","confidence":"Medium","size":25,"edges":26,"triangles":2,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0051591","count":1},{"id":"GO:0006734","count":1},{"id":"GO:0006096","count":1}]},{"hash":"2105716015565611813","title":"Chromatin regulation via histone modification","description":"This cluster\u2019s GO terms cluster around epigenetic control: histone methylation/demethylation and regulation of chromatin states (H3 and H4 marks) and RITS complex localization, pointing to chromatin remodeling and transcriptional silencing as the common theme. A few terms are peripheral or obsolete, but the dominant signal is epigenetic regulation of chromatin, making this label representative.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061188","count":1},{"id":"GO:0035574","count":1},{"id":"GO:1900113","count":1},{"id":"GO:0048821","count":1},{"id":"GO:0018395","count":1}]},{"hash":"1149707019587149796","title":"RNAi and small RNA processing","description":"The dominant GO terms point to RNA interference, piRNA/miRNA processing, and co-transcriptional gene silencing, with related signals for heterochromatin formation and germline maintenance. This suggests a cluster of proteins involved in small RNA biogenesis and RNA-mediated silencing, rather than a single enzyme or pathway. Despite the presence of obsolete terms, the core theme is coherent and centered on RNAi-related processing and silencing.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0090625","count":1},{"id":"GO:0070924","count":1},{"id":"GO:0030718","count":1},{"id":"GO:0010050","count":1}]},{"hash":"740339174010300380","title":"Embryonic Development and Cell Adhesion","description":"This cluster\u2019s top GO terms are centered on developmental processes (nervous system development, in utero embryonic development) and cell\u2013cell/matrix interactions (cell adhesion, vascular permeability). While there are also terms related to transcription and cell cycle regulation (kinetochore localization, CDK activity), the dominant theme appears to be development and adhesion, suggesting a coordinated role in tissue formation and organization.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0001701","count":2}]},{"hash":"970725590870448646","title":"Unknown","description":"The top GO terms are diverse and include DNA repair, translesion synthesis, transport across epithelia, signaling regulation, and neuronal development, with no single shared function or dense connectivity. Because there is no cohesive theme binding the terms, a specific label cannot be reliably assigned.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006297","count":2},{"id":"GO:0042276","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0070634","count":1},{"id":"GO:0098713","count":1}]},{"hash":"127329335182078496","title":"Developmental Processes and Chromatin Assembly","description":"The proteins in this cluster are enriched for broad developmental roles (gonad and brain development, fertilization, bone formation, growth) and for chromatin-related processes (CENP-A\u2013containing and replication-dependent chromatin assembly), with supporting signals of transcriptional regulation and mRNA surveillance. This suggests a cluster centered on development with links to chromatin organization and gene expression control.","confidence":"Medium","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0070481","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0035264","count":2}]},{"hash":"1316669301735135419","title":"Retroviral integration and latency","description":"The top GO terms point to core retroviral life cycle events: DNA integration into the host genome, proviral latency, viral entry and nuclear penetration, and release, alongside downstream effects on host translation, gene expression, and proteolysis. Together these terms outline a theme of viral infection and manipulation of host cell biology, consistent with a retroviral integration/latency cluster.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0019076","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0075732","count":2}]},{"hash":"462105079372195283","title":"Blood coagulation and ECM remodeling","description":"This cluster is enriched for GO terms related to fibrinolysis, plasminogen activation, blood coagulation, extracellular matrix disassembly, tissue remodeling, and cell adhesion, indicating a cohesive theme of hemostasis and extracellular matrix turnover. Some terms (e.g., response to yeast) may be peripheral noise, but the core signals point to coagulation and ECM remodeling processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0051919","count":3},{"id":"GO:1902947","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0031639","count":3}]},{"hash":"296803302007710824","title":"Plant light signaling and circadian regulation","description":"The dominant GO terms point to light perception and circadian control in plants (red/far-red phototransduction, far-red signaling pathway, and positive regulation of circadian rhythm), with transcriptional regulation as a downstream process, suggesting a module of phytochrome-driven signaling. Some terms (apoptotic DNA fragmentation, erythrocyte differentiation) are less aligned and may reflect annotation noise, but the main theme remains clear.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006309","count":2},{"id":"GO:0030218","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0009585","count":2},{"id":"GO:0042753","count":2}]},{"hash":"1791920678174213929","title":"Neural axon guidance and angiogenesis","description":"Explanation: The top GO terms cluster around neural development and vascular morphogenesis, including commissural axon guidance, axon extension, facial nerve organization, sympathetic neuron projection guidance, otic placode development, and VEGF/neuropilin signaling involved in axon guidance and angiogenesis. This suggests a shared theme of coordinated neural patterning with vascular development, likely mediated by VEGF signaling. ","confidence":"High","size":23,"edges":13,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0048010","count":4},{"id":"GO:0021612","count":3},{"id":"GO:0097491","count":3},{"id":"GO:0048846","count":3}]},{"hash":"100033778393280201","title":"Keratinocyte development and immune signaling","description":"Top GO terms point to epidermal differentiation (keratinocytes), multicellular development, receptor-driven signaling (including PI3K/AKT) with VEGF responsiveness, and immune-related responses (muramyl dipeptide) plus apoptotic regulation. This suggests a skin-development program with integrated signaling and immune components, rather than a single metabolic pathway.","confidence":"Medium","size":23,"edges":8,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0035924","count":5},{"id":"GO:0032495","count":5},{"id":"GO:0043113","count":5}]},{"hash":"105140999923297049","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":40,"triangles":30,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000480","count":6},{"id":"GO:0000462","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000463","count":6},{"id":"GO:0000398","count":6}]},{"hash":"1672154314453367105","title":"Cardiovascular and neural development signaling","description":"The top GO terms are driven by heart development processes (cardiac right atrium morphogenesis, atrioventricular node development, Notch signaling in heart field regulation) and venous endothelial differentiation, with neuronal terms (learning, neurotransmitter secretion, synaptic transmission, AMPA receptor activity) suggesting shared developmental signaling roles in nervous system contexts. Together, they point to developmental signaling programs operating in both cardiovascular and neural systems rather than a single specific mature function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060843","count":3},{"id":"GO:0003270","count":3},{"id":"GO:0071372","count":3},{"id":"GO:0003213","count":3},{"id":"GO:0007612","count":3}]},{"hash":"1057706396491849857","title":"Nervous system development and cell cycle regulation","description":"This cluster centers on neural development signals, with terms like excitatory postsynaptic potential, Schwann cell development, and myelination in peripheral nervous system, indicating neuronal/glial differentiation. It also includes core cell cycle processes (G1/S transition, DNA replication, kinetochore localization, meiotic cell cycle), suggesting some members share proliferative roles. Overall, the terms point to nervous system development intertwined with general cell cycle regulation.","confidence":"Medium","size":23,"edges":16,"triangles":5,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0051321","count":4},{"id":"GO:0014883","count":4},{"id":"GO:0000082","count":4},{"id":"GO:0042220","count":4}]},{"hash":"1584250892627321296","title":"Dendritic spine morphogenesis and Rho signaling","description":"Top GO terms indicate a focus on synapse assembly and cytoskeletal regulation, including dendritic spine morphogenesis, protein localization to synapse, receptor clustering, and Rho GTPase signaling with activation of GTPase activity. While broader terms like centrosome cycle and multicellular development are present, the core cluster appears to drive spine formation and Rho-mediated signaling at synapses, justifying a name centered on these processes.","confidence":"Medium","size":23,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0007098","count":2},{"id":"GO:0071479","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0043113","count":2}]},{"hash":"1588447415716799432","title":"Dopaminergic signaling and sensory perception","description":"The cluster is enriched for neural signaling and sensory processing terms, including dopaminergic synaptic transmission, visual perception and learning, pain perception, and cocaine-related behavioral responses, along with ERK signaling. Some developmental terms appear, but the dominant theme is dopamine-mediated neural communication and sensory function.","confidence":"High","size":23,"edges":33,"triangles":15,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":7},{"id":"GO:0048148","count":7},{"id":"GO:0071380","count":7},{"id":"GO:0010759","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1254083904026010138","title":"CoA and Pantothenate Metabolism and Immune Signaling","description":"The cluster is dominated by coenzyme A and pantothenate metabolism terms (CoA biosynthesis, pantothenate catabolic process, acetyl-CoA biosynthetic process from pantothenate). A few terms point to immune signaling and host interactions (symbiont entry into host cell, leukocyte tethering or rolling, regulation of JNK cascade), and there are also ribosome biogenesis signals. Because no single theme clearly emerges as dominant, the label emphasizes the core metabolic link with cautious note of the immune/signaling hints.","confidence":"Low","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0050901","count":2},{"id":"GO:0090004","count":2}]},{"hash":"354348082776204551","title":"Developmental cell migration and cytoskeleton dynamics","description":"The top terms cluster around embryonic development, neural crest cell migration, cell adhesion, and actin cytoskeleton organization, indicating a shared role in cell movement and morphogenesis; mechanotransduction and ubiquitination reflect regulation during these processes, with some context-specific terms like SA node action potential likely not central to the main theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000209","count":5},{"id":"GO:0007155","count":3},{"id":"GO:0001755","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0030036","count":2}]},{"hash":"1390021251551693113","title":"Ribosome biogenesis and translation machinery","description":"This cluster is dominated by terms related to protein synthesis and ribosome function, including cytoplasmic translation, mitochondrial translational elongation, translation initiation complex formation, and ribosome biogenesis, suggesting a coherent theme around the cellular machinery for protein production. A couple of outlying terms (neuronal signaling responses) appear less central but do not override the core translation signature. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000413","count":2},{"id":"GO:0043278","count":2}]},{"hash":"1794546012909932234","title":"Actin Cytoskeleton Remodeling and Migration","description":"The cluster is dominated by GO terms for actin cytoskeleton organization, cell migration, and modulation of cytoskeleton dynamics (including GTPase activity and microtubule depolymerization), pointing to a cohesive theme of cytoskeletal remodeling and motility. Secondary terms reference DNA replication and cell cycle regulation, and stress responses, suggesting some proteins also participate in broader cellular regulation.","confidence":"High","size":23,"edges":27,"triangles":13,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015991","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0007026","count":3},{"id":"GO:0007050","count":3},{"id":"GO:0043547","count":3}]},{"hash":"626566417181715458","title":"Neural signaling and plasticity","description":"The top GO terms point to nervous system functions\u2014nonassociative learning, behavioral response to ethanol, regulation of synapse structure or activity, and ventral spinal cord development\u2014suggesting a neural signaling/plasticity theme. Rho signaling also supports cytoskeletal and signaling roles common in neurons. However, several terms pertain to non-neural processes (mitosis exit, mitochondrial DNA replication, migration, adipogenesis), indicating the cluster is not exclusively neural, so the confidence in a single cohesive theme is moderate.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046958","count":1},{"id":"GO:0007266","count":1},{"id":"GO:0021517","count":1},{"id":"GO:0048149","count":1},{"id":"GO:0010458","count":1}]},{"hash":"1404421861364324568","title":"Unknown","description":"The cluster\u2019s top GO terms span transcriptional regulation, angiogenesis, immune defense, signaling, glucose response, development, and extracellular matrix remodeling, showing no single cohesive function. This diversity makes it hard to assign a specific, representative label.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0045766","count":9},{"id":"GO:0050830","count":9},{"id":"GO:0014068","count":9},{"id":"GO:0071333","count":9}]},{"hash":"558809479199442271","title":"Developmental signaling and secretory trafficking","description":"This cluster groups proteins tied to developmental processes (heart development, regulation of dendritic spine development) and to the secretory pathway and calcium handling (COPII vesicle budding, ER unfolded protein response, calcium homeostasis). The combination suggests a link between developmental signaling and intracellular trafficking/ER function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0010765","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1631076604482705912","title":"B cell signaling and calcium release regulation","description":"The presence of GO terms tied to B cell receptor signaling, follicular B cell differentiation, and IP3-mediated calcium release indicates a focus on B cell\u2013centered signaling and calcium flux. Additional terms on Ras, Rho, and insulin signaling suggest broader signaling regulation that modulates these pathways. Overall, the cluster appears to represent B cell\u2013centered calcium signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051281","count":2},{"id":"GO:0032959","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0050861","count":2},{"id":"GO:0032869","count":2}]},{"hash":"1323018234711250228","title":"Mitotic cell cycle and neural development signaling","description":"Top terms are dominated by DNA replication and mitotic cell cycle (DNA replication, G2/M transition, mitotic cell cycle), pointing to a core cell-cycle regulatory function. The presence of axonogenesis and excitatory postsynaptic potential, along with embryonic cranial skeleton morphogenesis and transcription regulation, suggests additional roles in neural development and signaling. The dominant theme is mitotic cell cycle with ancillary developmental signaling.","confidence":"High","size":22,"edges":80,"triangles":142,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0000086","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0045944","count":5}]},{"hash":"662138244967468515","title":"Developmental cytoskeletal remodeling and chromatin modification","description":"This cluster features actin cytoskeleton dynamics (Arp2/3\u2013mediated nucleation, sarcomere organization) together with histone acetylation, and includes development-related terms across neurons, lens fibers, skeletal tissues, and multicellular development, plus cytokinesis regulation. ","confidence":"Medium","size":22,"edges":22,"triangles":1,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043982","count":4},{"id":"GO:0043981","count":4},{"id":"GO:0034314","count":4},{"id":"GO:0045214","count":3},{"id":"GO:0000281","count":3}]},{"hash":"181303635528959573","title":"Translation Machinery and Transcription Regulation","description":"Most terms focus on translation and ribosome biogenesis (translation, formation of translation preinitiation complex, translation reinitiation, ribosomal large subunit biogenesis) and on RNA polymerase II\u2013mediated transcription regulation (positive/negative regulation). A related set links transcription to DNA repair (transcription-coupled nucleotide-excision repair), suggesting involvement of transcription-associated machinery. Overall, the cluster centers on core gene expression processes\u2014protein synthesis with transcriptional control\u2014warranting a translation/transcription-focused label.","confidence":"High","size":22,"edges":86,"triangles":139,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006283","count":5},{"id":"GO:0008283","count":5},{"id":"GO:0014070","count":4},{"id":"GO:0042273","count":4}]},{"hash":"591827423575515312","title":"RNA processing and ribosome biogenesis","description":"This cluster repeatedly maps to RNA processing: spliceosome-mediated mRNA splicing, regulatory ncRNA-mediated gene silencing, ribosome biogenesis (preribosome large subunit assembly and LSU rRNA maturation), and stress-related mRNA stability regulation, indicating a coherent theme of RNA maturation and ribosome production.","confidence":"High","size":22,"edges":93,"triangles":139,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0042255","count":6},{"id":"GO:1902626","count":6}]},{"hash":"421065263090295011","title":"Nuclear RNA Processing and Chromatin Regulation","description":"The cluster is dominated by spliceosome- and RNA processing-related GO terms (mRNA splicing, regulatory ncRNA-mediated silencing, transcription termination, rRNA processing, and mRNA decay), indicating a core role in nuclear RNA processing and gene expression control. Additional chromatin-related terms (heterochromatin maintenance, histone exchange) and DNA replication hint at broader genome regulation activities alongside RNA processing.","confidence":"High","size":22,"edges":217,"triangles":1291,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":12},{"id":"GO:0048026","count":12},{"id":"GO:0000398","count":12},{"id":"GO:0006369","count":11},{"id":"GO:0000464","count":11}]},{"hash":"2105080591693795734","title":"Retinoid and Neuronal Metabolism","description":"The top GO terms cluster around retinoid metabolism (retinol and retinal processes) and neural-related activities (GABA catabolism, neuron migration), supported by energy metabolism (TCA cycle) and amino acid biosynthesis signals, suggesting a metabolic network tied to neural development and retinal chemistry. Some terms appear peripheral (platelet aggregation, antibiotic biosynthesis), but the dominant pattern centers on retinoid metabolic pathways and neural context.","confidence":"Medium","size":22,"edges":128,"triangles":397,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042572","count":6},{"id":"GO:0042574","count":6},{"id":"GO:0009447","count":5},{"id":"GO:0070527","count":5}]},{"hash":"1964735506669553524","title":"Neurovascular development and ERK signaling","description":"The GO terms cluster around vascular and neural development (angiogenesis, endothelial migration, nervous system development, dendrite morphogenesis) with a central emphasis on ERK1/ERK2 cascade signaling. This suggests a cohesive theme of neurovascular development coordinated by ERK pathway activity, making the label representative of the cluster\u2019s function. ","confidence":"High","size":22,"edges":9,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0014068","count":4}]},{"hash":"772283700533136136","title":"Signaling regulation and actin remodeling","description":"Top terms indicate regulation of multiple signaling pathways (Rho, Ras/ERK, BMP, PI3K) and actin-driven processes (lamellipodium assembly). The shared theme is regulatory control of signaling cascades together with cytoskeletal remodeling, suggesting proteins that coordinate signaling and actin dynamics rather than a single pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007596","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0030513","count":2}]},{"hash":"822320417476262603","title":"Neuronal vesicle fusion and neurotransmitter signaling","description":"The top GO terms cluster around synaptic vesicle dynamics and signaling: intracellular protein transport, regulation of GABAergic synaptic transmission, vesicle fusion, and regulation of dopamine secretion, with phosphatidylinositol signaling and IP3 biosynthesis that coordinate vesicle cycling at synapses. This points to a cohesive theme of vesicle trafficking and neurotransmitter release in neurons.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0032228","count":3},{"id":"GO:0048015","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0031340","count":2}]},{"hash":"580403887916414026","title":"Organogenesis and tissue differentiation","description":"Top terms cluster around developmental processes across multiple organs and tissues (liver development, thyroid gland development, pharyngeal system development, mesodermal cell fate specification, chondrocyte differentiation regulation, skeletal muscle fiber differentiation, fungiform papilla morphogenesis). There are also roles in muscle satellite cell proliferation and neuron survival, aligning with broader developmental signaling and lineage specification. The cytokinin-activated signaling term appears anomalous, likely annotation noise, but the prevailing pattern supports organogenesis-related functions.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009736","count":3},{"id":"GO:0001889","count":2},{"id":"GO:0060037","count":2},{"id":"GO:0007501","count":2},{"id":"GO:1902723","count":2}]},{"hash":"1541718707021535703","title":"Core transcription and cell cycle processes","description":"The top GO terms cluster around nuclear gene expression and cell cycle activities: transcription elongation, mRNA export from the nucleus, DNA replication, mitotic cell cycle, and chaperone-mediated protein complex assembly. These suggest a group of proteins involved in maintaining gene expression and progression through cell division, with a few broader annotations (e.g., angiogenesis, immune response) likely reflecting multifunctional roles or annotation overlaps in diverse proteins.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0071629","count":2}]},{"hash":"1996230229981470256","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0014068","count":3}]},{"hash":"280671427261073457","title":"Developmental Processes","description":"The GO terms cluster around development across tissues: ossification and bone maturation, spermatid development, facial nerve organization, and axon guidance, with supporting roles in transcription regulation, vesicle transport, and autophagy. This suggests a broad theme of growth, differentiation, and tissue organization, rather than a single specific pathway, so the label \u201cDevelopmental Processes\u201d captures the overall function with moderate confidence.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0006893","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007286","count":2}]},{"hash":"466600720450942144","title":"Developmental differentiation and migration regulation","description":"This cluster features GO terms tied to several differentiation programs (erythrocyte, trophoblast giant cell, myoblast) and to regulation of cell movement and cytoskeletal signaling (negative regulation of Rho signaling, mononuclear cell migration). While apoptosis-related terms appear, they are not dominant. The common thread appears to be developmental differentiation coupled with control of cell migration, hence this label. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006309","count":1},{"id":"GO:0030218","count":1},{"id":"GO:0030336","count":1},{"id":"GO:0035024","count":1},{"id":"GO:0060707","count":1}]},{"hash":"1700618668365071758","title":"Cardiac GPCR Signaling and Muscle Contraction","description":"Based on the GO terms, the cluster centers on heart/ cardiac muscle functions and GPCR signaling: heart development, cardiac muscle contraction, vasoconstriction, GPCR desensitization and internalization, and tachykinin receptor signaling. These together suggest a cohesive theme of GPCR-regulated cardiac muscle activity and vascular tone, with a few broader terms (platelets, cell cycle) that may reflect wider GPCR-related signaling connections. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:2000045","count":2},{"id":"GO:0070527","count":2},{"id":"GO:0045988","count":2},{"id":"GO:0002029","count":2}]},{"hash":"1526173080668577636","title":"RNA processing and translation initiation machinery","description":"This cluster's top GO terms cluster around mRNA splicing, modification, and polyadenylation, plus multiple aspects of translation initiation and initiation-factor complex assembly. The presence of small-subunit processome assembly hints at RNA processing in the nucleus, while eIF4F complex assembly and regulation of translational initiation point to cytoplasmic translation machinery. Taken together, these terms suggest a group of proteins involved in RNA maturation/processing and initiation of translation. Note: there are some obsolete terms in the list, but the dominant theme remains RNA processing and translation initiation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":2},{"id":"GO:0006376","count":1},{"id":"GO:0016556","count":1},{"id":"GO:0031047","count":1},{"id":"GO:0006378","count":1}]},{"hash":"532848383529782630","title":"Ubiquitin-Proteasome Regulation in Cell Cycle","description":"The top GO terms point to ubiquitin-dependent proteolysis pathways (SCF- and APC-mediated degradation, ubiquitination), indicating a cluster centered on regulated protein degradation. Several terms emphasize proteasomal catabolic processes and ubiquitin signaling, consistent with cell cycle control and proteolytic regulation. While there are hints of chromatin organization and genome maintenance, the dominant theme is ubiquitin-mediated protein turnover connected to cell cycle regulation.","confidence":"Medium","size":21,"edges":7,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0006626","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0000722","count":2}]},{"hash":"274363383433113387","title":"Ribosome/Translation Machinery","description":"The cluster is dominated by translation and ribosomal subunit assembly terms (GO:0006412, GO:0000027), suggesting proteins mainly involved in the ribosome/translation apparatus. The presence of xenobiotic response and various development annotations may reflect multi-function annotations or incidental associations, but the core signal points to ribosomal/translation machinery.","confidence":"High","size":21,"edges":13,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000027","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0060041","count":2}]},{"hash":"1638128136283526667","title":"Neural development and sensory-behavioral responses","description":"This cluster combines terms tied to neural development (multicellular organism development, neural tube closure, skeletal development) with processes related to sensory perception and behavioral responses (pain perception, visual learning, cocaine-induced behavior) and signaling pathways (ERK cascade). The mixture suggests proteins involved in nervous system development and the regulation of neural signaling that governs responses to sensory stimuli and drugs, plus related stress and inflammatory signals (cadmium, prostaglandin). Overall, a cohesive theme around neural development and stimulus-driven behavior is most representative. ","confidence":"Medium","size":21,"edges":20,"triangles":8,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":16},{"id":"GO:0019233","count":16},{"id":"GO:0008542","count":15},{"id":"GO:0048148","count":15},{"id":"GO:0070374","count":15}]},{"hash":"999837972532003188","title":"DNA Replication and Mitosis","description":"Top GO terms cluster around mitotic processes and DNA replication (spindle assembly, sister chromatid cohesion regulation, and DNA replication), with supporting roles from proteasome assembly in cell-cycle progression. Some terms (viral genome replication, nuclear mRNA decay, responses to cold/pain) are broader or peripheral annotations, but the dominant signal reflects replication and chromosome maintenance during cell division.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:1904908","count":2},{"id":"GO:0019079","count":2},{"id":"GO:0006260","count":2},{"id":"GO:1902600","count":2}]},{"hash":"266069652218026713","title":"DNA replication, repair, and genome maintenance","description":"The cluster is dominated by GO terms for DNA replication, recombination, DNA repair, and error-free translesion synthesis, with apoptotic and xenobiotic-stress response terms that together point to a DNA damage response/genome maintenance theme. A cerebral cortex development term appears but is likely incidental noise relative to the core DNA-centric functions. ","confidence":"High","size":21,"edges":81,"triangles":187,"max_degree":15,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0006260","count":7},{"id":"GO:0042493","count":4},{"id":"GO:0021987","count":4},{"id":"GO:0006278","count":4}]},{"hash":"376494540021334626","title":"Unknown","description":"The GO terms span sensory transduction (phototransduction, pain perception), environmental/thermal responses (temperature stimulus, diet-induced thermogenesis), apoptotic processes in liver and immune cells, and various signaling/regulatory processes (GTPase activity, phosphatidylinositol biosynthesis) without a single clear unifying function. This makes it hard to assign a concise, representative label beyond Unknown with no confidence. ","confidence":"","size":21,"edges":58,"triangles":83,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0007603","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0097284","count":5}]},{"hash":"1898719441010916063","title":"Unknown","description":"The top GO terms are very diverse, including fungal lipid metabolism (mannosyl-inositol phosphorylceramide metabolic process, ergosterol biosynthesis, unsaturated fatty acid biosynthesis), Golgi organization (Golgi ribbon formation), mitochondrial inheritance, and various vertebrate or insect development terms (CNS myelin maintenance, sebaceous gland differentiation, egg-laying behavior). There is no clear single theme tying these terms together across the proteins, so a cohesive functional label isn\u2019t supported.","confidence":"","size":21,"edges":20,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006675","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0006809","count":2},{"id":"GO:0006636","count":2}]},{"hash":"1805891251334889260","title":"RNA Processing and Gene Expression Regulation","description":"The top GO terms cluster around RNA processing and gene expression control, including mRNA export from the nucleus, spliceosome-mediated mRNA splicing, regulation of translational initiation, and transcription elongation by RNA polymerase II. Regulatory ncRNA-mediated gene silencing also appears, supporting a cohesive module of RNA maturation and expression regulation. A couple of terms (lipopolysaccharide biosynthesis and response to antibiotic) look like outliers, but the dominant signal points to a shared function in RNA processing.","confidence":"High","size":21,"edges":36,"triangles":20,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0009103","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0032968","count":3},{"id":"GO:0031047","count":3}]},{"hash":"2172781971378892186","title":"Ribosome Biogenesis and Proteasomal Degradation","description":"The top GO terms are dominated by rRNA maturation and processing (maturation of SSU/5.8S/LSU rRNA and rRNA processing), which points to ribosome biogenesis. A strong secondary signal is ubiquitin-proteasome\u2013dependent protein catabolism (APC/C- and SCF-dependent pathways), indicating regulation of protein turnover. Additional terms cover ER\u2013Golgi transport and GTPase activity, suggesting broader cellular logistics, but the clearest connection across terms is ribosome assembly with coordinated protein degradation. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0031146","count":2}]},{"hash":"622589713279114327","title":"Unknown","description":"The GO terms span diverse biosynthetic processes (antibiotic, biotin, cobalamin, tRNA methylation), development (pancreas morphogenesis, multicellular organism growth), stress responses, transcription regulation, and immune defense, with no single shared pathway apparent and no edges connecting proteins; thus there isn\u2019t a coherent function to name beyond Unknown.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0009102","count":3},{"id":"GO:0030488","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0035264","count":3}]},{"hash":"214474994802608291","title":"Proteoglycan and Glycosaminoglycan Biosynthesis","description":"The Top Terms are dominated by proteoglycan and glycosaminoglycan biosynthetic processes (heparan sulfate, chondroitin sulfate, keratan sulfate) and related carbohydrate metabolism, indicating a coherent theme of extracellular matrix proteoglycan synthesis, with a couple of ancillary metabolic terms. This supports a cohesive label focused on ECM proteoglycan production.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0015012","count":2},{"id":"GO:0006805","count":2},{"id":"GO:0006584","count":2},{"id":"GO:0006044","count":2}]},{"hash":"484157892596444684","title":"RNA Pol II Transcription and Chromatin Regulation","description":"The cluster centers on RNA polymerase II\u2013related processes (preinitiation complex assembly and transcription) and chromatin modification (histone deubiquitination/acetylation), with a subset of terms pointing to nutrient-stress\u2013driven growth responses (pseudohyphal and invasive growth). Some other terms (endosperm/neuronal development, inositol phosphate metabolism) may reflect broader annotations or incidental associations, but do not define a single cohesive pathway. Overall, it seems to group transcriptional regulation and chromatin state with growth responses under nutrient stress.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016578","count":2},{"id":"GO:0001403","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0007124","count":1}]},{"hash":"114445643013510285","title":"Developmental differentiation and ER stress responses","description":"GO terms point to tissue-specific differentiation (lens fiber, skin, erythrocyte, multicellular development) alongside stress- and trafficking-related processes (ER-stress\u2013induced intrinsic apoptotic signaling, apoptotic DNA fragmentation, phagolysosome assembly, COPII-coated vesicle budding). This suggests a broad theme of developmental differentiation tied to cellular stress responses and vesicular transport, rather than a single, cohesive pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0001845","count":2}]},{"hash":"497054588957185295","title":"Biosynthesis and RNA Modification","description":"This cluster\u2019s GO terms cover a broad set of biosynthetic pathways (biotin, ubiquinone, polyamine, vitamin E, antibiotic) plus RNA and protein modification activities (tRNA wobble uridine modification, rRNA modification, peptidyl-arginine methylation). The lack of edges/triangles suggests these proteins may act in diverse biosynthetic and modification processes rather than a single cohesive pathway, supporting a high-level label rather than a narrow function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0016049","count":1},{"id":"GO:0001300","count":1},{"id":"GO:0019919","count":1}]},{"hash":"2227687335636873862","title":"Vertebrate Development and Morphogenesis Regulators","description":"The set is dominated by developmental processes across multiple tissues (brain development, male gonad development, single fertilization, primitive streak formation, branching morphogenesis, osteoblast differentiation, multicellular growth), plus a strong signal for transcriptional regulation (negative regulation of transcription by RNA polymerase II). This combination points to a cluster of factors governing vertebrate development and organogenesis, with some remodeling/immune-related terms that may reflect broader tissue remodeling contexts. Overall, a cohesive theme is developmental regulation and morphogenesis.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0008584","count":6},{"id":"GO:0007338","count":6},{"id":"GO:0050830","count":5},{"id":"GO:0035264","count":5}]},{"hash":"1374841544538503020","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":102,"triangles":293,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006268","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0000742","count":2},{"id":"GO:0055003","count":2}]},{"hash":"1624693642147810897","title":"Neural signaling and visual perception","description":"This cluster is enriched for sensory and neural signaling terms, notably visual learning, visual perception, and dopaminergic synaptic transmission, along with behavioral responses to cocaine and ERK signaling regulation. Prostaglandin-related signaling suggests neuronal/metabolic cross-talk, supporting a brain-centric theme; although a few terms like heart development and macrophage chemotaxis appear, the dominant pattern points to neural signaling and vision/reward pathways.","confidence":"Medium","size":20,"edges":58,"triangles":61,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":9},{"id":"GO:0048148","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0071380","count":9},{"id":"GO:0010759","count":9}]},{"hash":"500365170460148614","title":"Unknown","description":"The protein set shows no cohesive functional theme; terms touch neural signaling (sensory perception of sound, regulation of neuronal action potential) but also DNA repair, apoptosis, metabolism, viral interaction, and mitochondrial mRNA processing, with only sparse connections (3 edges, no triangles). Without a clear shared function, a reliable label cannot be assigned.","confidence":"","size":20,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0035019","count":2},{"id":"GO:0032425","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0044830","count":1}]},{"hash":"404856592435168920","title":"Post-transcriptional mRNA processing and splicing regulation","description":"The top GO terms point to mRNA processing and regulation, including splicing by the spliceosome, mRNA stability, mRNA modification, and translational initiation control, with links to regulatory ncRNA-mediated gene silencing. This suggests a cohesive module focused on post-transcriptional gene expression control and RNA maturation.","confidence":"High","size":20,"edges":189,"triangles":1122,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":15},{"id":"GO:0031047","count":12},{"id":"GO:0048026","count":12},{"id":"GO:0006378","count":10},{"id":"GO:0000398","count":10}]},{"hash":"863326610010916709","title":"Wnt/MAPK signaling in neural development","description":"The proteins are enriched for neural development and signaling activities, notably positive regulation of canonical Wnt signaling, JNK and ERK/MAPK cascades, dendrite morphogenesis, neural tube closure, and excitatory synaptic activity. This suggests a cohesive module coordinating neural development and signaling through Wnt and MAPK pathways; peripheral terms like cell cycle, cadmium response, and focal adhesion regulation may reflect broader roles of some components.","confidence":"High","size":20,"edges":40,"triangles":33,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":16},{"id":"GO:0000278","count":16},{"id":"GO:0048813","count":15},{"id":"GO:0043304","count":15},{"id":"GO:0046330","count":15}]},{"hash":"2244655708259998729","title":"Developmental transcriptional regulation","description":"Most prominently, several GO terms indicate transcriptional activity (DNA-templated transcription) and broad developmental processes (multicellular organism development, forebrain development, neural tube closure, skeletal system development). This points to proteins involved in regulating gene expression during embryogenesis and organ development. While immune and stress-response terms (defense to Gram-positive bacteria, cadmium ion response) appear, the dominant signal is developmental transcriptional regulation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0050830","count":3}]},{"hash":"1979064819903200599","title":"Ubiquitin-Dependent Protein Degradation","description":"Based on the top GO terms, this cluster is dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, protein polyubiquitination, and autoubiquitination. Some members are involved in signaling regulation (JNK cascade, TNF signaling) and chromatin-related modifications, with a few terms reflecting neural development and other pathways. The common thread is ubiquitin modification controlling protein fate and signaling.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0051865","count":4},{"id":"GO:0046328","count":4},{"id":"GO:0022028","count":3},{"id":"GO:0000209","count":3}]},{"hash":"1056540728861346403","title":"Unknown","description":"The GO terms are highly diverse, including transcription initiation, androgen receptor signaling, stem cell maintenance, LDL receptor\u2013related processing, receptor recycling, protein autoprocessing, and respiratory tube development. There is no single, dominant function that unifies these entries; they span transcriptional regulation, signaling, metabolism, and development. Without a coherent theme, a specific functional label cannot be confidently assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":1},{"id":"GO:0030521","count":1},{"id":"GO:0019827","count":1},{"id":"GO:1905596","count":1},{"id":"GO:0032802","count":1}]},{"hash":"396919034037862315","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0070317","count":2},{"id":"GO:0032211","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1576014160050890925","title":"Dendrite morphogenesis and vesicle trafficking","description":"The top GO terms converge on vesicle transport processes (Golgi to plasma membrane, endocytic recycling, lysosomal transport, vesicle size regulation) along with dendrite development and morphogenesis, and neuron survival signals. This pattern suggests a cohesive functional module of proteins coordinating vesicle trafficking in neurons to drive dendrite formation and maintenance. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006893","count":3},{"id":"GO:0032456","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0048813","count":3},{"id":"GO:0043524","count":3}]},{"hash":"315936597767557041","title":"Neural development and synaptic signaling","description":"The majority of top GO terms point to neuronal development and synaptic function (axonogenesis; excitatory postsynaptic potential; long-term potentiation; synaptic signaling). Several terms also reference glial/nerve support (Schwann cell development) and broader developmental processes (heart development). Some cell cycle terms appear, reflecting general proliferation aspects in development but do not contradict the neural theme. Overall, the cluster seems enriched for proteins involved in neural differentiation and synaptic plasticity.","confidence":"Medium","size":20,"edges":8,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0010800","count":3}]},{"hash":"1128446141614299921","title":"Neuronal development and gene expression regulation","description":"This cluster centers on developmental processes, especially neuronal development and regulation of synaptic plasticity, and is complemented by GO terms for transcription and translation, including rRNA maturation. The combination suggests coordinated gene expression control during neuronal development, rather than a single, narrow pathway. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0021860","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0000462","count":2}]},{"hash":"1579009403060237220","title":"Ribosome Biogenesis and Cell Cycle Regulation","description":"This cluster is dominated by GO terms for ribosome biogenesis and export (ribosome biogenesis, ribosomal large subunit biogenesis, ribosomal large subunit export from nucleus) along with cell cycle-related terms (cell cycle, traversing start control point of mitotic cell cycle) and actin cytoskeleton organization, suggesting a core theme of ribosome assembly supporting cell growth and division. Some other terms (growth factor response, pollen recognition, synaptic transmission) appear incidental but do not override the central ribosome-cycle pattern.","confidence":"Medium","size":20,"edges":17,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0048544","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0007049","count":1}]},{"hash":"2173913699869183945","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039702","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0010587","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0019068","count":1}]},{"hash":"553066504523565492","title":"RNA silencing and miRNA processing","description":"The GO terms indicate involvement in RNA interference and silencing pathways, including siRNA/miRNA processing, ta-siRNA processing, co-transcriptional gene silencing, and regulatory ncRNA\u2013mediated heterochromatin formation, with vegetative phase change suggesting plant development context; together these point to small RNA\u2013guided transcriptional and post-transcriptional regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0090625","count":3},{"id":"GO:0070924","count":3},{"id":"GO:0010050","count":3},{"id":"GO:0090502","count":3}]},{"hash":"617829913809272126","title":"RNA Processing and Transcription Cluster","description":"This cluster is dominated by GO terms for RNA processing and mRNA splicing (mRNA processing; mRNA splicing via spliceosome) and DNA-templated transcription, with additional hints of related regulatory and developmental processes. The strongest signal points to RNA metabolism and transcriptional regulation, suggesting these proteins primarily function in RNA processing and gene expression control, while the developmental terms may reflect broader roles or context-specific functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0007018","count":2}]},{"hash":"1657500646540025919","title":"Neural development and neuronal differentiation","description":"The top GO terms cluster around neuronal development and cell fate specification, including spinal cord motor neuron and oligodendrocyte differentiation, subpallium neuron fate commitment, and cortical interneuron differentiation, plus related transcriptional regulation. While there are also broader developmental terms (bronchiole, pancreas, osteoblast development), the strongest and most consistent signal is neural development and neuronal differentiation, making this a representative label for the cluster.","confidence":"Medium","size":19,"edges":126,"triangles":564,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0060435","count":12},{"id":"GO:0021520","count":12},{"id":"GO:0060766","count":12},{"id":"GO:0021530","count":12},{"id":"GO:0031018","count":12}]},{"hash":"1741651594424868354","title":"Retroviral DNA Integration and Nuclear Entry","description":"The top GO terms cluster around steps of the retroviral life cycle: RNA-templated DNA biosynthetic process (reverse transcription), DNA integration, proviral latency, and penetration of the viral genome into the host nucleus. Some other terms (brain development, glycogen catabolism, ossification) appear as unrelated noise, but the strongest signals support a retroviral integration/entry theme.","confidence":"High","size":19,"edges":22,"triangles":14,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0007420","count":2},{"id":"GO:0005980","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1966959089588390635","title":"Protein methylation and rRNA processing","description":"The cluster's top GO terms are dominated by protein methylation and rRNA processing, suggesting roles in post-translational modification and ribosome biogenesis. While several biosynthetic pathway terms appear, the strongest and most coherent themes are methylation and RNA processing, supporting a focused interpretation around protein modification and ribosome assembly.","confidence":"Medium","size":19,"edges":17,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006479","count":3},{"id":"GO:0006364","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0016049","count":2}]},{"hash":"1430173292090763515","title":"Developmental signaling and cytoskeletal dynamics","description":"This cluster combines vertebrate developmental processes (cochlea morphogenesis, globus pallidus and skeletal muscle development) with signaling pathway regulation (Wnt, glucocorticoid signaling) and cytoskeletal/exocytotic activity (exocytosis, actin filament bundle assembly), along with core gene expression processes (transcription, translation). The recurring themes point to developmental signaling intertwined with cytoskeletal dynamics, justifying the label.","confidence":"Medium","size":19,"edges":8,"triangles":2,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006887","count":5},{"id":"GO:0090103","count":5},{"id":"GO:0030111","count":5},{"id":"GO:0050859","count":4},{"id":"GO:0006412","count":4}]},{"hash":"1117724931559550974","title":"Glycoside and lactose carbohydrate catabolism","description":"These terms (glucuronoside catabolic process, polysaccharide catabolic process, lactose catabolic process) consistently point to the enzymatic breakdown of glycosides and other carbohydrates, including lactose. The cluster appears to group proteins involved in general carbohydrate degradation rather than a single substrate, justifying a label centered on glycoside and lactose catabolism.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019391","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0005990","count":1}]},{"hash":"1469673107703555167","title":"Embryonic neural and skeletal development","description":"Most of the high-frequency GO terms cluster around embryonic development, especially neural development (neuron development, neural tube closure) and skeletal system formation (embryonic cranial skeleton morphogenesis, skeletal system development), with broader multicellular organism development and epigenetic regulation by imprinting also fitting vertebrate embryogenesis. There are a few terms that are less obviously connected (e.g., DNA replication, stress responses), but the dominant theme is embryonic tissue patterning and organogenesis, particularly neural and skeletal lineages.","confidence":"High","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":12},{"id":"GO:0006349","count":12},{"id":"GO:0048701","count":11},{"id":"GO:0048666","count":11},{"id":"GO:0071276","count":11}]},{"hash":"1101072960786536183","title":"Central carbon metabolism and vitamin biosynthesis","description":"The cluster is dominated by GO terms for glycolysis, the TCA cycle, and biosynthesis of cofactors like thiamine and biotin, all pointing to core energy metabolism and vitamin/cofactor production. Oxidative stress response also features prominently, reinforcing a metabolic-maintenance theme. A few terms (e.g., platelet aggregation, neuron migration) appear as less representative annotations, but the prevailing signal aligns with central metabolism and cofactor biosynthesis.","confidence":"High","size":19,"edges":78,"triangles":132,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0009228","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0006979","count":3}]},{"hash":"245927650301401873","title":"Notch-regulated skin and bone development","description":"The GO terms point strongly to skin development, bone ossification, and hair follicle orientation, all of which are regulated by Notch signaling, suggesting a developmental cluster focused on integumentary and skeletogenic processes. Coupled with endoderm differentiation and neural/excitability terms (startle response, circadian rhythm), the set appears to group proteins involved in Notch-driven developmental signaling affecting skin, hair, and bone, with ancillary neuronal regulation. ","confidence":"Medium","size":19,"edges":16,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":4},{"id":"GO:0001964","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0098703","count":4},{"id":"GO:0043588","count":4}]},{"hash":"1646439267163102742","title":"Neural and Visual Development","description":"Dominant terms point to nervous system and visual development (forebrain, visual perception/learning), with calcium-dependent exocytosis and Rho signaling suggesting neuronal communication; some heart/development terms are present but less representative.","confidence":"Medium","size":19,"edges":36,"triangles":40,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":8},{"id":"GO:0007507","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0034198","count":6},{"id":"GO:0007266","count":6}]},{"hash":"821978169841321230","title":"Cytoskeletal remodeling and vesicle trafficking in development","description":"This cluster is dominated by GO terms tied to actin cytoskeleton dynamics (Arp2/3-mediated nucleation, GTPase regulation, microtubule severing), signaling (serine/threonine kinases), and vesicle transport (ER to Golgi), with developmental processes such as multicellular development and cell proliferation. The convergence of cytoskeletal remodeling, signaling, and trafficking supports a cohesive theme of cytoskeletal dynamics driving development.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0051260","count":4},{"id":"GO:2000601","count":4},{"id":"GO:0071902","count":4},{"id":"GO:0030433","count":4}]},{"hash":"388839505541072952","title":"Blood Coagulation and Fibrinolysis with ECM Remodeling","description":"The cluster is dominated by GO terms related to coagulation and fibrinolysis (blood coagulation, fibrinolysis, plasminogen activation, regulation of circulating fibrinogen levels) and extracellular matrix remodeling (tissue remodeling, extracellular matrix disassembly), indicating a shared role in clot dynamics and ECM turnover. A few terms like midbrain development are ancillary and not core to the main theme. This pattern supports a cohesive label around hemostasis and matrix remodeling rather than transcriptional regulation. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0051919","count":7},{"id":"GO:1902947","count":7},{"id":"GO:0042730","count":7},{"id":"GO:0031639","count":7}]},{"hash":"787682288698336285","title":"Neuronal development and synaptic vesicle exocytosis","description":"The top GO terms emphasize brain development and regulation of synaptic vesicle exocytosis, with supporting signals from phosphatidylinositol-mediated signaling, suggesting a core theme around neuronal development and synaptic transmission. Some terms (mitotic spindle assembly, mating projection growth, neutrophil regulation) appear peripheral, indicating broader functional diversity, but the strongest clustering centers on neural growth and synaptic signaling.","confidence":"Medium","size":19,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0090307","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0031384","count":3}]},{"hash":"1517665117030394762","title":"Actin Remodeling in Immune Cell Migration","description":"This cluster is dominated by GO terms for actin cytoskeleton organization, lamellipodium/microspike assembly, Rac signaling, and neutrophil chemotaxis, pointing to actin-driven cell movement in immune cells. IL-4 production further supports an immune context, suggesting coordinated signaling and motility. A placental development term is incidental, not central to the main theme.","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001893","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0032633","count":2},{"id":"GO:0035020","count":2},{"id":"GO:0030035","count":2}]},{"hash":"2061444088784713143","title":"Unknown","description":"The GO terms span a mix of spermatid and neuronal development, CSF secretion, various membrane transport processes, blood pressure regulation, chromatin localization, and inflammatory signaling with no single dominant function. There are no interactions among proteins (Edges: 0), suggesting no cohesive biological theme, so a precise functional label is not supported.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0032760","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0033326","count":2}]},{"hash":"123278454062199262","title":"Ribosome Biogenesis and Translation","description":"The cluster's top GO terms are dominated by translation and ribosome-related processes (translation, ribosome biogenesis, small subunit assembly and export, SSU-rRNA maturation). This suggests proteins involved in ribosome assembly, rRNA processing, and protein synthesis; the occasional stress-response terms may reflect cellular responses to antibiotics or cytokines but do not override the ribosome-focused pattern.","confidence":"High","size":19,"edges":169,"triangles":936,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0042254","count":7},{"id":"GO:0046677","count":6},{"id":"GO:0006407","count":5},{"id":"GO:0000028","count":2}]},{"hash":"1930004694086080361","title":"Developmental Regulation with Cytoskeleton and Chromatin","description":"The top GO terms revolve around broad developmental processes across multiple tissues (neuron projection development, lens fiber differentiation, seminiferous tubule development, skeletal system development, multicellular organism development) while also highlighting cytoskeletal dynamics (negative regulation of Arp2/3) and chromatin modification (histone acetylation). This suggests a theme of coordinating organismal development with cytoskeletal remodeling and epigenetic regulation, even though the Protein Interaction network shows few or no direct edges. Therefore, a label capturing development plus cytoskeletal and chromatin regulation fits best.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034316","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0070317","count":3},{"id":"GO:0072520","count":3}]},{"hash":"1345013139348694572","title":"Unknown","description":"The top GO terms span highly diverse processes (antibiotic, biotin, and porphyrin/lysine biosynthesis; translation; development events like wing fate and spermatid differentiation; EGFR ligand maturation; ER-to-cytosol proteolysis; NK cell regulation), indicating no single cohesive biological function ties these proteins together. Therefore, there isn\u2019t a clear, representative label beyond Unknown.","confidence":"","size":19,"edges":122,"triangles":430,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0006412","count":2}]},{"hash":"2005288651037169268","title":"Cardiac Muscle Regulation and Adrenergic Signaling","description":"The top GO terms point to cardiac muscle contraction/relaxation, regulation of cardiac hypertrophy, and signaling pathways tied to epinephrine and cGMP, plus calcium handling via the sarcoplasmic reticulum, indicating a cohesive theme of heart muscle physiology and adrenergic responsiveness (with a few ancillary vascular/immune-related terms).","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043116","count":3},{"id":"GO:0033159","count":3},{"id":"GO:0010880","count":2},{"id":"GO:0086004","count":2},{"id":"GO:0042053","count":2}]},{"hash":"1077825837536904290","title":"Actin Remodeling and Cell Adhesion","description":"The cluster\u2019s top GO terms center on actin cytoskeleton dynamics (actin polymerization, ruffle assembly), membrane trafficking (endocytosis, engulfment of apoptotic cells), and cell\u2013cell/matrix adhesion (tight junction assembly, substrate adhesion-dependent spreading), with supportive links to synaptic plasticity and Wnt signaling. This points to proteins coordinating actin-driven shape changes and endocytic trafficking during adhesion remodeling and development.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":2},{"id":"GO:0097178","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0090263","count":2},{"id":"GO:1900026","count":2}]},{"hash":"2258230309278297595","title":"Unknown","description":"The top GO terms span apoptosis, signaling, plant-specific processes, and neuronal development, with no single cohesive function tying all proteins together. None","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006309","count":3},{"id":"GO:0030218","count":3},{"id":"GO:0070059","count":1},{"id":"GO:0045746","count":1},{"id":"GO:0006751","count":1}]},{"hash":"1103187970305916096","title":"RNA Pol II Transcription Regulation and Epigenetic Control","description":"The cluster shows a strong emphasis on RNA polymerase II\u2013driven transcription regulation (initiation, regulation, and negative regulation) and chromatin-level control (DNA methylation\u2013dependent heterochromatin formation, histone methylation). While a few terms like viral process or rRNA maturation appear, the dominant pattern ties transcription control to epigenetic and chromatin-modifying processes. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0006367","count":2},{"id":"GO:0006355","count":2}]},{"hash":"1984973044602338281","title":"Embryonic morphogenesis and transcriptional regulation","description":"This cluster centers on developmental processes, especially embryonic organ morphogenesis (eye development, hindlimb, placenta, heart structures) and tight transcriptional control via RNA polymerase II (transcription and its negative regulation). The presence of eye-specific terms (embryonic eye morphogenesis, camera-type eye development) alongside broader organogenesis terms suggests a module of transcription-regulating proteins orchestrating embryonic development across tissues. Network metrics (Edges 106, Triangles 278) support a cohesive functional group.","confidence":"High","size":18,"edges":106,"triangles":278,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0048048","count":7},{"id":"GO:0006366","count":6},{"id":"GO:0060441","count":5},{"id":"GO:0043010","count":5}]},{"hash":"2189610893673137658","title":"Cytoskeleton remodeling and migration signaling","description":"The terms cluster around signaling pathways that regulate actin cytoskeleton organization and cell movement, including stress fiber assembly, establishment of actin polarity, wound healing, and ERK signaling, with supporting membrane trafficking (COPII) and guidance cues (ROBO/Roundabout) that influence migration in development and immune contexts. This points to a cohesive function in cytoskeleton remodeling during cell migration and tissue remodeling.","confidence":"Medium","size":18,"edges":111,"triangles":327,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0090114","count":5},{"id":"GO:0043149","count":4}]},{"hash":"367663217229358569","title":"Viral entry, DNA integration, and proviral latency","description":"The GO terms cluster around viral infection processes: DNA integration, proviral latency establishment, and viral penetration into the host nucleus, suggesting a virus-host interaction and genome integration theme. Additional terms like symbiont entry into host cells and symbiont-mediated activation of host apoptosis support viral manipulation of the host, while DNA replication and mRNA processing reflect common cellular contexts during infection.","confidence":"High","size":18,"edges":36,"triangles":21,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0050798","count":3},{"id":"GO:0046718","count":3}]},{"hash":"332320396574440219","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":11,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071042","count":2},{"id":"GO:0071051","count":2},{"id":"GO:0071038","count":2},{"id":"GO:0071035","count":2},{"id":"GO:0000467","count":2}]},{"hash":"980514661635508499","title":"mRNA Splicing and Processing Regulation","description":"The cluster centers on spliceosome-mediated mRNA splicing and broader processing steps, including mRNA export, modification, and regulation of stability and translation, with both positive and negative regulators of splicing, indicating a cohesive set of proteins involved in mRNA maturation and control.","confidence":"High","size":18,"edges":71,"triangles":159,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0048025","count":7}]},{"hash":"857176096088204151","title":"Nutrient-sensing autophagy and TORC1 signaling","description":"This cluster centers on autophagy-related processes (microautophagy; positive and negative regulation of autophagy), and cellular responses to amino acid availability (amino acid starvation/stimulus) with TORC1 signaling and vacuolar localization/transport, all pointing to a coordinated nutrient-sensing autophagy program. Some terms like subtelomeric heterochromatin formation and RNA polymerase III transcription may be ancillary annotations, but the dominant theme is autophagy regulation in response to amino acid signals via TORC1 and vacuolar trafficking.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016237","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0034198","count":2},{"id":"GO:0006383","count":2}]},{"hash":"148189489374702508","title":"Vesicle trafficking and endosomal localization","description":"Proteins in this cluster are enriched for vesicle transport and localization to endosomes (Rab signaling, endosome targeting, regulation of vesicle size), along with membrane organization processes like tight junction assembly. The prominent endomembrane trafficking signals, plus some related functions (neuron/dendrite development, cell cycle), point to a core role in vesicle movement and protein targeting rather than a single enzymatic activity.","confidence":"High","size":18,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":2},{"id":"GO:0036010","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0071701","count":1},{"id":"GO:0016358","count":1}]},{"hash":"145601718091421112","title":"ECM Remodeling in Development","description":"These proteins cluster around extracellular matrix remodeling and proteolysis involved in shaping tissues. Terms like collagen catabolic process and basement membrane disassembly point to proteases and ECM modifiers driving matrix remodeling. Bone resorption and decidualization indicate remodeling in bone and reproductive tissues, while lung branching morphogenesis and thyroid hormone\u2013stimulated cellular response reflect developmental and hormone-regulated morphogenesis. Together, the group seems to function in proteolytic remodeling of the extracellular matrix during organogenesis and tissue remodeling.","confidence":"Medium","size":18,"edges":38,"triangles":38,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0097067","count":5},{"id":"GO:0045453","count":4},{"id":"GO:0034769","count":4},{"id":"GO:0060448","count":4},{"id":"GO:2000179","count":4}]},{"hash":"1559928665224431915","title":"Calcium-NFAT Muscle Development","description":"The strongest signal in this cluster is calcium-related signaling paired with the calcineurin-NFAT pathway and skeletal muscle fiber development, suggesting a calcium-dependent NFAT-driven role in muscle differentiation. Additional GO terms point to vesicle trafficking and nuclear pore organization that can accompany cellular signaling and protein transport in muscle cells; the taste-related terms are minor outliers. Overall, the core theme is calcium-dependent NFAT signaling promoting muscle development.","confidence":"Medium","size":18,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050916","count":2},{"id":"GO:0050913","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0005513","count":2},{"id":"GO:0048741","count":2}]},{"hash":"1950982607938955678","title":"Embryonic organogenesis and placental differentiation","description":"The prominent GO terms cluster around placental/trophoblast differentiation, mesoderm development, and broader organogenesis (endocrine system, palate, cartilage, left-right patterning), indicating a cohesive theme of embryonic development with placental lineage involvement.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0060536","count":4}]},{"hash":"482470031695324854","title":"Inflammation and coagulation responses","description":"These GO terms cluster around immune/inflammatory signaling and blood coagulation: response to lipopolysaccharide, acute-phase response, and regulation of fibrinogen levels, all pointing to inflammation and hemostasis. A few terms (pain, visual perception, heart development) are less connected and may reflect broader or secondary associations, but the dominant theme is inflammatory/coagulation processes.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0019233","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1313612404798274496","title":"Neural Development and Synaptic Vesicle Trafficking","description":"The cluster is enriched for neural development terms (spinal cord development, brain development) and vesicle-related processes (synaptic vesicle priming and budding) along with microtubule-based movement and regulation of signaling pathways (Rho/Ras). This combination suggests proteins involved in neural development and the trafficking/ release of synaptic vesicles, reflecting coordinated neuronal growth and synaptic function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0016082","count":2}]},{"hash":"801169096837615774","title":"Muscle structure and cell migration","description":"The top GO terms center on cytoskeletal organization and muscle-related development: sarcomere organization, skeletal muscle fiber development, and swimming, which together point to muscle structure and locomotion. Additional terms about cell migration and adhesion-dependent spreading reinforce a theme of cytoskeletal remodeling governing movement. Some terms (ubiquitin-dependent protein catabolic process, memory T cell differentiation, germinal center formation) appear more peripheral or noise-like, not tying strongly into a single cohesive module. Overall, the cluster seems to reflect cytoskeletal/muscle-associated processes with migratory potential.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":2},{"id":"GO:1900026","count":2},{"id":"GO:2000312","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0043380","count":1}]},{"hash":"358759386929092317","title":"Regulation of translation initiation and viral translation","description":"The cluster is dominated by GO terms centered on initiation of translation and its regulation, including regulation of translational initiation, formation of preinitiation/cytoplasmic initiation complexes, translation reinitiation, and IRES-dependent viral translation. This points to a cohesive role in controlling translation initiation, especially in viral contexts, with a couple of peripheral terms related to transcription or proliferation that are less central to the main theme.","confidence":"High","size":17,"edges":12,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1927659522778000474","title":"Transcriptional Regulation in Development","description":"The top GO terms cluster around transcription by RNA polymerase II and regulation of transcription, including stress-responsive regulation, alongside a diverse set of development-related processes (placenta development, imaginal disc fusion, osteoblast proliferation, thorax closure, cuticle pigmentation, locomotor rhythm). This points to a group of proteins that coordinate developmental programs mainly through transcriptional control across species.","confidence":"Medium","size":17,"edges":127,"triangles":574,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0036091","count":5},{"id":"GO:0001892","count":4},{"id":"GO:0034670","count":4},{"id":"GO:0009737","count":4}]},{"hash":"820302845267082455","title":"Bacterial central metabolism and quinone biosynthesis","description":"This cluster centers on energy-producing and carbon-processing pathways, with GO terms for glycolytic process, fatty acid beta-oxidation, glyoxylate catabolic process, and biosynthesis of quinones (phylloquinone and menaquinone), plus poly-hydroxybutyrate biosynthesis and sporulation-related processes. The combination suggests a cohesive bacterial metabolic module involved in central carbon metabolism and production of electron carriers, rather than a single isolated pathway. ","confidence":"Medium","size":17,"edges":77,"triangles":210,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0009234","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0042619","count":2},{"id":"GO:0030435","count":2}]},{"hash":"1986029613319638923","title":"Unknown","description":"The terms span DNA transcription and replication, neural development (forebrain, neural tube), multicellular development, immune signaling (T cell receptor pathway, defense against Gram-positive bacteria), and stress responses (cadmium ion). This broad mix lacks a single cohesive function, so a specific, intuitive label isn\u2019t supported by the GO enrichment in this cluster.","confidence":"","size":17,"edges":12,"triangles":4,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0006260","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0071276","count":8},{"id":"GO:0001843","count":8}]},{"hash":"554687306955750268","title":"DNA Damage Response and Metabolic Signaling","description":"This cluster is strongly enriched for DNA repair and replication terms (DNA repair, DNA replication, response to ionizing radiation) alongside metabolic stress signals (CAMKK-AMPK signaling cascade, cellular response to glucose stimulus). The presence of cell-cycle related terms (mitotic centrosome separation) and broader stress/immune responses (interferon-beta production, defense response to Gram-positive bacterium) suggests a cohesive network linking genome maintenance with metabolic and stress signaling. Overall, it reflects genome integrity maintenance under metabolic and environmental stress.","confidence":"Medium","size":17,"edges":41,"triangles":29,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071333","count":13},{"id":"GO:0006281","count":13},{"id":"GO:0006260","count":13},{"id":"GO:0050830","count":13},{"id":"GO:0061762","count":12}]},{"hash":"2071822868720799969","title":"Splicing and mRNA processing with translation control","description":"This cluster centers on post-transcriptional gene expression: many proteins are linked to mRNA splicing via the spliceosome (including regulation of splicing, splice-site recognition, and core splicing), plus related processes such as mRNA modification and regulation of mRNA stability under stress. It also includes components of the translation initiation complex and translation reinitiation, indicating a link between RNA processing and translation control. Overall, the dominant GO terms point to RNA processing and translational regulation as the cluster's core function.","confidence":"High","size":17,"edges":90,"triangles":251,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":11},{"id":"GO:0031047","count":10},{"id":"GO:0010610","count":9},{"id":"GO:0001731","count":8},{"id":"GO:1901407","count":8}]},{"hash":"1867285619797491694","title":"Brain Development and Retinal Metabolism","description":"The top GO terms indicate neural development (forebrain development, neuronal migration to the olfactory bulb) and cognitive aspects (associative learning), suggesting proteins involved in brain maturation and neural circuitry. Retinal/metabolic terms (retinol and retinal metabolism) reinforce a link to the visual system; together these point to neurodevelopment with retinal involvement. Some terms appear less coherent (obsolete or non-neural processes), but the dominant theme remains brain development and retinal metabolism.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0008306","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0022028","count":3},{"id":"GO:0042572","count":2}]},{"hash":"177403480780184652","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:1901407","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0048568","count":2},{"id":"GO:0021510","count":2}]},{"hash":"1285380500321479277","title":"Neural and cardiovascular development","description":"The Top Terms mix neural development and synaptic processes (axon extension, synapse assembly, dopaminergic transmission, grooming behavior) with cardiovascular/vascular development (coronary artery morphogenesis, atrioventricular node development, endothelial chemotaxis regulation). This suggests a cohesive theme of developmental signaling affecting both nervous and cardiovascular systems, with additional related processes like nitric oxide biosynthesis and fibrinogen regulation. Note: the obsolete oxidation-reduction term can be disregarded in this context.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0060982","count":5},{"id":"GO:2001027","count":5}]},{"hash":"158574528160420911","title":"Neuronal vesicle trafficking and dendrite development","description":"Based on the prominent terms about neurotransmitter receptor transport to the postsynaptic membrane, endocytosis, dendrite development, cell polarity, and vesicle size regulation, the proteins likely cluster around neuronal synaptic trafficking and dendritic morphogenesis. Some terms are less coherent (e.g., spermatid development, subtelomeric heterochromatin formation) and a few are marked obsolete, so the theme is present but not perfect. ","confidence":"Medium","size":17,"edges":26,"triangles":3,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071963","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0098887","count":4},{"id":"GO:0007286","count":4},{"id":"GO:0006897","count":4}]},{"hash":"281194472631300505","title":"Multisystem signaling and immune response","description":"This cluster shows a mix of signaling-related processes (MAPK/ERK cascade, TORC1 regulation) alongside innate immune responses, cell migration (macrophage chemotaxis), and responses to stimuli (prostaglandin, cocaine/visual learning). The presence of heart development and neural/behavioral terms alongside immune and stress signaling suggests a broad network of signaling and stress responses across multiple systems rather than a single, cohesive function.","confidence":"Medium","size":17,"edges":32,"triangles":6,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":4},{"id":"GO:0048148","count":4},{"id":"GO:0034198","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0070374","count":4}]},{"hash":"1089452888931402262","title":"DNA transposition and proviral integration","description":"This cluster's top GO terms cluster around DNA transposition, DNA integration, retrotransposition, and proviral latency/viral genome entry, indicating a core theme of mobile genetic elements and virus-associated genome integration; the vesicle trafficking terms appear to be background noise relative to this signal.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070676","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0006313","count":1},{"id":"GO:0046718","count":1}]},{"hash":"965029581160823618","title":"Angiogenesis and Growth Factor Signaling in Development","description":"The top GO terms are dominated by angiogenesis and regulation of angiogenesis, plus development-related processes (multicellular organism development) and responses to growth factors (e.g., hepatocyte growth factor). Receptor clustering and signaling-related neuronal terms (synaptic potentiation, excitatory postsynaptic potential) suggest broader signaling roles that can intersect with angiogenic pathways during development. A background rRNA maturation term appears but does not define the primary theme. Overall, the cluster seems best described by angiogenesis and growth factor\u2013mediated signaling in development.","confidence":"Medium","size":17,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0071333","count":2}]},{"hash":"384990560298515377","title":"Ubiquitin/Neddylation-Dependent Protein Degradation","description":"Most of the top GO terms describe ubiquitin-dependent protein catabolism and modifiers: ubiquitination, autoubiquitination, protein turnover via the MVB sorting pathway, and the post-translational modification neddylation. A few terms (actin filament severing, V(D)J recombination, TNF signaling) are less central but can connect to ubiquitin pathways in immune signaling and cytoskeleton dynamics. Overall, the cluster appears to collect proteins involved in ubiquitin- and neddylation-mediated protein turnover. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051014","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0045116","count":2},{"id":"GO:0043162","count":2}]},{"hash":"1027261576011165483","title":"RNA Processing and Translation Initiation Machinery","description":"The top GO terms cluster around RNA metabolism and early translation steps: mRNA splice site recognition, mRNA modification, regulatory ncRNA-mediated gene silencing, and small-subunit processome assembly, indicating RNA processing and maturation. Concurrently, terms for translating initiation\u2014formation of the translation preinitiation complex, eIF4F complex assembly, and regulation of translational initiation\u2014point to involvement in assembling and regulating the ribosomal initiation machinery. Some obsolete terms appear but do not change the overall theme of RNA processing plus translation initiation proteins.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":3},{"id":"GO:0016556","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0006446","count":3}]},{"hash":"1772140637851928646","title":"Cell growth, division, and translation","description":"The top GO terms point to core cellular machinery: ribosome biogenesis and cytoplasmic translation indicate protein synthesis capacity; mitotic spindle assembly relates to cell division; cell polarity hints at morphogenesis and cytoskeletal organization; vesicle size regulation and nucleolus localization reflect trafficking and nucleolar functions; and CAMKK-AMPK signaling links growth with energy sensing. These collectively suggest a cluster centered on fundamental growth and division processes intertwined with protein synthesis, rather than a highly specialized pathway. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071963","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0002181","count":2}]},{"hash":"1945188123347158538","title":"Fungal sporulation and cytoskeletal remodeling","description":"Top GO terms point to ascospore formation, nuclear migration in conjugation, mitotic spindle assembly, cell cycle, cell polarity and actin dynamics (including actin filament uncapping and microspike assembly), and exocytosis, collectively indicating fungal sporulation with cytoskeleton-driven cell division and shape changes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030437","count":2},{"id":"GO:0000743","count":2},{"id":"GO:0070527","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0006887","count":1}]},{"hash":"162147597006839827","title":"Unknown","description":"The top terms span RNA processing, transcription/DNA replication regulation, ribosome export, signaling, and various sensory and growth processes, with no clear unifying function. Edges are absent, suggesting no cohesive interaction pattern tying these proteins to a single pathway.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0032298","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0070427","count":1}]},{"hash":"1370369418673147990","title":"Neuroendocrine and reproductive organ development","description":"These proteins are enriched for GO terms related to neural and neuroendocrine development (brain development, midbrain development, pituitary gland development) and reproductive organ formation (male gonad development, single fertilization), plus embryonic cranial skeleton morphogenesis. The presence of transcriptional regulation and chromatin remodeling terms suggests coordinated gene expression control during development. Overall, the cluster appears to represent factors involved in embryonic neuroendocrine and reproductive organ development.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0021983","count":5},{"id":"GO:0008584","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0007420","count":4}]},{"hash":"709140585686902104","title":"Developmental patterning and organ morphogenesis","description":"This cluster centers on GO terms tied to development across multiple organs (uterus, forebrain, heart, mammary gland) and morphogenesis (branching). It also includes signaling pathways like integrin-mediated and Rac signaling, which are key in developmental signaling and tissue remodeling. A few immune-related terms (IL-4 production, regulation of NK cell cytotoxicity) may reflect immune- or microenvironment-related aspects of development. Taken together, the dominant theme is development and organ morphogenesis with associated signaling.","confidence":"Medium","size":16,"edges":16,"triangles":13,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060065","count":11},{"id":"GO:0009952","count":11},{"id":"GO:0030900","count":10},{"id":"GO:0007229","count":9},{"id":"GO:0045953","count":8}]},{"hash":"1939212338502202541","title":"Vertebrate Embryogenesis and Neural Development","description":"GO terms point to vertebrate development, especially neural development (midbrain and cortex patterning, neuron and neural crest migration) along with other organogenesis (pancreas, bone, digestive tract). The presence of transcriptional regulation implicates these proteins as regulators during embryogenesis. Overall, the cluster seems to group vertebrate embryonic and neural development processes.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":5},{"id":"GO:0031018","count":4},{"id":"GO:0090190","count":3},{"id":"GO:0048557","count":3}]},{"hash":"2244578221734723045","title":"Notch-regulated keratinocyte differentiation and inflammation","description":"Top GO terms cluster around Notch receptor processing and the negative regulation of Notch signaling, together with keratinocyte differentiation and inflammatory responses (e.g., TNF, inflammatory response). This suggests a functional module where Notch signaling modulates epidermal cell fate and immune/inflammatory signaling, with some development-related terms reflecting broader roles of Notch. Therefore, a label focusing on Notch-regulated keratinocyte differentiation and inflammation captures the shared function of these proteins.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":6},{"id":"GO:0001824","count":5},{"id":"GO:0007220","count":5},{"id":"GO:0030216","count":5},{"id":"GO:0010042","count":5}]},{"hash":"1988779927996799188","title":"ER-Golgi Transport and RNA Processing","description":"The cluster is enriched for vesicle transport between the ER and Golgi (both forward and retrograde), indicating a vesicle trafficking module. In addition, several terms relate to RNA metabolism (mRNA transport/splicing, transcription) and growth signaling (TORC1, GTPase regulation), suggesting a broader coordination between trafficking and RNA processing.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0038202","count":4},{"id":"GO:0070262","count":4},{"id":"GO:0070317","count":3}]},{"hash":"769297490572067498","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":14,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042619","count":3},{"id":"GO:0006541","count":2},{"id":"GO:0042351","count":2},{"id":"GO:0033320","count":2}]},{"hash":"1927806648029633471","title":"ER unfolded protein response and ER-to-Golgi trafficking","description":"The cluster is characterized by ER-focused processes: unfolded protein response in the ER, COPII vesicle budding, ER localization, and calcium homeostasis, all pointing to ER quality control and ER-to-Golgi trafficking. A couple of terms about host-virus interactions and endocytosis are present but less central to the main theme.","confidence":"High","size":16,"edges":35,"triangles":10,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030968","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0006987","count":2},{"id":"GO:0006874","count":2},{"id":"GO:0070972","count":2}]},{"hash":"1948470436844396338","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":1},{"id":"GO:0031990","count":1},{"id":"GO:0006383","count":1},{"id":"GO:0006384","count":1},{"id":"GO:0006366","count":1}]},{"hash":"769882937671271949","title":"Nuclear replication and transport","description":"The cluster is dominated by nuclear-centric processes: DNA replication, regulation of protein export from the nucleus, and tRNA import into the nucleus, with additional signals related to protein complex regulation and ATP-dependent activity. Although there are some development-related terms (mesoderm formation, hedgehog-related patterning), the strongest and most frequent terms point to chromatin/nuclear maintenance and transport rather than a single developmental signaling pathway. Confidence: Medium.","confidence":"","size":16,"edges":16,"triangles":0,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0001707","count":5},{"id":"GO:0071374","count":5},{"id":"GO:0046825","count":5},{"id":"GO:1901621","count":5}]},{"hash":"2299318433423508101","title":"Unknown","description":"The GO terms are disparate, including meiosis cytokinesis, chloride transport, bitter taste detection, tooth dentin formation, estrogen response, CO2 transport, and various signaling pathways. There is no coherent biological process linking these terms, suggesting the cluster lacks a unified function label.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007112","count":2},{"id":"GO:2001225","count":1},{"id":"GO:0010043","count":1},{"id":"GO:0071498","count":1},{"id":"GO:0001580","count":1}]},{"hash":"788150742915249998","title":"RNA Splicing and mRNA Processing","description":"The top GO terms are dominated by spliceosome-related processes (spliceosomal snRNP assembly, mRNA splicing via spliceosome, mRNA polyadenylation), pointing to a core function in RNA processing. While there are additional terms (immune cell homeostasis, ER folding, autophagy, sensory functions) present, they appear less central to the cluster\u2019s core signal. Therefore, a label centered on RNA splicing/processing best captures the shared function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001782","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0000387","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2}]},{"hash":"1298493453316890353","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009113","count":1},{"id":"GO:0006750","count":1},{"id":"GO:0006189","count":1},{"id":"GO:0039657","count":1},{"id":"GO:0010923","count":1}]},{"hash":"573564354190476543","title":"Ribosome biogenesis and SRP-mediated targeting","description":"The top GO terms are dominated by ribosome biogenesis and SRP-dependent cotranslational protein targeting to membranes, hinting at a shared role in assembling ribosomal components and directing nascent proteins to membranes. Other terms (pigmentation, various developmental processes) are present but at lower counts, making them less representative of a single cohesive function. Overall, the core signal points to translation machinery and membrane targeting rather than a unified developmental phenotype.","confidence":"Low","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0001649","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0035551","count":1},{"id":"GO:0070527","count":1}]},{"hash":"297190885527652622","title":"Spermatogenesis and germ cell redox signaling","description":"This cluster is dominated by GO terms for male gonad development and spermatogenesis, indicating a primary role in germ cell production. Additional terms point to oxidative stress responses and redox regulation (removal of superoxide radicals, oxidation processes) and stress signaling (MAPK, NF-kappaB), suggesting that these germ cell processes are linked with cellular redox regulation and stress responses. RNA processing terms hint at coordinated gene expression control during germ cell development.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":3},{"id":"GO:0007283","count":3},{"id":"GO:0006396","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0061407","count":2}]},{"hash":"1208982699398103025","title":"Developmental organogenesis and neural axon guidance","description":"The top GO terms point to broad organ development (heart, placenta, uterus, thyroid, cerebellum, retina, cranial skeleton) together with neural wiring (motor neuron and retinal ganglion cell axon guidance), suggesting proteins involved in developmental patterning and neural connectivity across multiple tissues.","confidence":"High","size":15,"edges":26,"triangles":11,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":15},{"id":"GO:0007507","count":15},{"id":"GO:0007275","count":15},{"id":"GO:0048701","count":15},{"id":"GO:0060065","count":14}]},{"hash":"806899025272028595","title":"Vertebrate Development and Stress-Driven Apoptosis","description":"Top GO terms indicate involvement in vertebrate development (forebrain, neural tube closure, skeletal system development, multicellular organism development, cardiac muscle apoptotic processes) along with stress-responsive signaling (TORC1 signaling, ER stress-induced apoptotic pathway, cadmium ion response). This suggests a cluster of proteins tied to developmental programs that can trigger apoptosis under stress, even though there are no apparent interaction edges. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0038202","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0001501","count":3}]},{"hash":"791248185043165465","title":"Neural development and transcriptional regulation","description":"The cluster is dominated by terms for nervous system development (central nervous system neuron development, neural tube closure, dendrite morphogenesis) and DNA-templated transcription, pointing to genes coordinating neural differentiation and neurite formation through transcriptional control. A few outliers relate to cadmium response or Gram-positive defense, but they do not override the neural theme.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0048813","count":8},{"id":"GO:0021954","count":8},{"id":"GO:0031100","count":8},{"id":"GO:0007399","count":8}]},{"hash":"1663461587199533154","title":"Triglyceride catabolism and lipid remodeling","description":"The cluster\u2019s top GO terms cluster around triglyceride breakdown (triglyceride catabolic process, triglyceride mobilization) and lipid remodeling (phosphatidylcholine catabolic process, triglyceride acyl-chain remodeling), suggesting a cohesive lipid metabolism module focused on triglyceride turnover and membrane lipid remodeling. Some terms like calcium transport and PKA regulation hint at linked signaling contexts, while a couple of terms reflect stress responses that may be tangential. Overall, these proteins most logically group as triglyceride catabolism and lipid remodeling actors.","confidence":"Medium","size":15,"edges":13,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060013","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0034638","count":2}]},{"hash":"998521892280084675","title":"Glutamatergic Synaptic Vesicle Trafficking & Plasticity","description":"Top GO terms indicate glutamatergic synaptic transmission, vesicle exocytosis, excitatory postsynaptic potentials, and brain development, with supporting vesicle trafficking processes (COPII budding, phosphatidylinositol dephosphorylation). The dominant theme is neuronal synaptic vesicle dynamics and signaling, suggesting functional coherence in glutamatergic neurotransmission and plasticity, despite a few less related terms. ","confidence":"High","size":15,"edges":88,"triangles":279,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0031384","count":4},{"id":"GO:0090114","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0060304","count":4},{"id":"GO:0048169","count":3}]},{"hash":"69465792296008133","title":"Endocytic trafficking and MVB biogenesis","description":"This cluster is characterized by GO terms centered on vesicle trafficking, endocytosis, and multivesicular body (MVB) formation \u2014 e.g., cytoplasm-to-vacuole targeting (Cvt), MVB assembly, and endocytic recycling \u2014 with additional signals of vesicle size regulation. A couple of terms (nucleolus localization, dendrite development) are less directly connected, likely reflecting broader protein roles or shared components. Overall, the dominant theme is endosomal/vesicular pathways. ","confidence":"Medium","size":15,"edges":6,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048873","count":4},{"id":"GO:0032258","count":4},{"id":"GO:0036258","count":4},{"id":"GO:0032456","count":4},{"id":"GO:0010796","count":4}]},{"hash":"666467165591908416","title":"Blood coagulation and fibrinolysis regulation","description":"The top GO terms point to coagulation and fibrinolysis processes: blood coagulation, plasminogen activation, regulation of fibrinogen levels, and Factor XII activation, plus positive regulation of fibrinolysis. Additional terms like response to lipopolysaccharide and smooth muscle cell migration fit vascular inflammation/remodeling that often accompanies coagulation. Overall, the cluster centers on hemostasis regulation rather than pain signaling, supporting this label.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0051919","count":5},{"id":"GO:0010756","count":5},{"id":"GO:0044537","count":5},{"id":"GO:0030194","count":5}]},{"hash":"2011444547275402109","title":"mRNA Splicing and Translation Initiation Regulation","description":"This cluster centers on RNA processing and control of protein synthesis. Dominant GO terms include regulation of translational initiation, formation of the translation preinitiation complex, mRNA splicing via the spliceosome, and mRNA export, with additional positive regulation of splicing. While some development-related terms are present, the shared theme across most terms is mRNA maturation and translation regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0003344","count":2}]},{"hash":"1098340135382920651","title":"RNAi and small RNA processing cluster","description":"The terms are dominated by RNA interference and small RNA biogenesis processes (siRNA, piRNA, and miRNA pathways) including processing and co-transcriptional silencing, plus RNAi-related antiviral immunity. A ribosome biogenesis term appears but is likely less representative. Overall, the cluster points to proteins involved in small RNA\u2013mediated gene regulation and silencing mechanisms.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0090625","count":1},{"id":"GO:0070924","count":1},{"id":"GO:0030718","count":1},{"id":"GO:0010050","count":1}]},{"hash":"396960592714711423","title":"Energy metabolism and core cellular processes","description":"This cluster centers on energy production (mitochondrial electron transport and oxidative phosphorylation) but also includes fundamental processes like translation, DNA replication, and cell division, plus ribosome biogenesis signals. The mix points to a broad set of housekeeping functions rather than a single pathway, with energy metabolism acting as the strongest common thread. Confidence reflects this broad, multi-function nature rather than a tight, cohesive module.","confidence":"Medium","size":15,"edges":91,"triangles":308,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1983632300201348451","title":"Auditory-vestibular neuromuscular signaling","description":"Based on the enrichment of terms related to cochlea and inner ear development, acetylcholine receptor signaling, excitatory/inhibitory postsynaptic potentials, and behaviors involving posture and locomotion (startle, walking), the cluster appears to group proteins involved in auditory/vestibular signaling and neuromuscular regulation of movement.","confidence":"Medium","size":15,"edges":13,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":4},{"id":"GO:0090102","count":4},{"id":"GO:0095500","count":4},{"id":"GO:0060080","count":4},{"id":"GO:2001226","count":4}]},{"hash":"48437897117413284","title":"Negative regulation of neural-vascular development","description":"The top GO terms point to brain development and negative regulation of neuronal processes (dendritic spine development) alongside negative regulation of vascular signaling and remodeling (VEGF receptor signaling, PDGFR-beta signaling, integrin-mediated adhesion), plus intracellular transport (COPII). This suggests a cohesive theme: a regulatory module that dampens signaling and trafficking related to neural and vascular development, rather than a single, narrow function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0090110","count":2},{"id":"GO:0001302","count":2}]},{"hash":"341288250643158496","title":"Unknown","description":"GO terms are diverse and there is no clear single function linking the proteins; only a few terms touch on muscle structure/contraction, while others relate to immune processes, development, or cell cycle, and there are no reported interactions. Therefore there is no cohesive theme to assign a specific label.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050765","count":1},{"id":"GO:0035626","count":1},{"id":"GO:0031032","count":1},{"id":"GO:1904706","count":1},{"id":"GO:0030855","count":1}]},{"hash":"68270627954383064","title":"Epithelial brush border formation and polarity","description":"Top GO terms cluster around epithelial features such as microvillus and brush border assembly, tight junction assembly, exocytosis, and centrosome localization, indicating apical polarity and cytoskeletal organization. The presence of Rho GTPase signaling and GTPase activation supports actin remodeling necessary for microvilli and polarized trafficking. Thus this cluster likely represents epithelial brush border formation and cell polarity processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0006887","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0051660","count":2}]},{"hash":"22187984243007680","title":"Golgi trafficking and oocyte polarity","description":"The top terms point to intracellular transport and Golgi-related processes (COPII-coated vesicle budding, regulation of Golgi organization, endosome transport) and oocyte-specific polarity (oskar mRNA localization, microtubule polarization). This suggests a cohesive theme around vesicle trafficking and cell polarity in oocytes, with other terms (transcription regulation, GTPase activity, DNA integration, immune defense) being less central. Overall, a trafficking/polarity-focused label best captures the cluster\u2019s core signal.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1596765174950797479","title":"Developmental and innate immune signaling","description":"Most terms point to mammalian development (blastocyst development, female pregnancy) and antiviral/innate immune responses (innate immune response, cellular response to interferon-alpha, dsRNA). A few terms appear anomalous (e.g., chlorophyll biosynthesis, urea homeostasis) and may reflect annotation noise, but the dominant pattern suggests proteins involved in developmental signaling and innate immunity. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001824","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0097274","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0015074","count":2}]},{"hash":"2175391244371242745","title":"Unknown","description":"Top terms span immune signaling, reproductive development, and neural processes with no single dominant function or shared pathway, and there are no network edges to tie these terms together. This heterogeneity suggests there isn\u2019t a cohesive biological theme for the cluster, so Unknown is the appropriate label.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060444","count":1},{"id":"GO:0042698","count":1},{"id":"GO:0010954","count":1},{"id":"GO:0000186","count":1},{"id":"GO:0032633","count":1}]},{"hash":"367018496285212106","title":"Immune antigen presentation and phagocytosis","description":"Top GO terms include peptide antigen assembly with MHC class I, positive regulation of phagocytosis, and dendritic cell chemotaxis, linking antigen processing and immune cell activation. Additional terms like endoplasmic reticulum unfolded protein response and protein folding suggest concurrent ER stress/quality-control roles, which often accompany immune signaling and antigen presentation pathways. Some unrelated terms are present, but the core themes point to immune processing and vesicle trafficking.","confidence":"Medium","size":14,"edges":19,"triangles":10,"max_degree":8,"top_function":"protein folding","top_go_terms":[{"id":"GO:2000510","count":3},{"id":"GO:0030968","count":3},{"id":"GO:0007339","count":3},{"id":"GO:0048488","count":3},{"id":"GO:0006457","count":3}]},{"hash":"2035121418695577082","title":"Mitotic spindle assembly and cell cycle","description":"Most top GO terms in this cluster describe mitosis and the cell cycle (mitotic spindle assembly, mitotic cell cycle, cell division). This suggests the proteins collectively participate in mitotic progression and chromosome segregation. Other terms (regulation of transcription, ERAD, xenobiotic response, protein autophosphorylation, GTP biosynthesis) are less dominant but may reflect regulatory or signaling roles tied to cell cycle control. Overall, the dominant mitosis-related signals justify labeling this cluster as related to mitotic spindle assembly and cell cycle.","confidence":"High","size":14,"edges":16,"triangles":2,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0071353","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0000278","count":3}]},{"hash":"2064596335382894651","title":"Nuclear RNA processing and chromatin regulation","description":"The set is dominated by nuclear RNA metabolism and processing terms: spliceosomal and snRNP assembly, P-body assembly, deadenylation-dependent decapping, import into the nucleus, and histone mRNA metabolism, plus pericentric heterochromatin formation. These point to coordinated RNA processing and chromatin maintenance in the nucleus, with a note that a few terms like hair cycle or ABA response may reflect broader or cross-species annotations, but the core signal is RNA processing and chromatin regulation.","confidence":"High","size":14,"edges":86,"triangles":314,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":11},{"id":"GO:0070317","count":11},{"id":"GO:0051170","count":11},{"id":"GO:0009737","count":11},{"id":"GO:0033962","count":11}]},{"hash":"2255180155795747764","title":"Unknown","description":"The cluster shows a highly diverse set of GO terms, including obsolete oxidation-reduction, transcription regulation by RNA polymerase II, keratinocyte differentiation, regulation of serine phosphorylation, Wnt signaling, potassium transport, nuclear import, GMP and fatty acid biosynthesis, and protein tetramerization, suggesting no single cohesive function or pathway links all members.","confidence":"","size":14,"edges":11,"triangles":0,"max_degree":11,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0045944","count":4},{"id":"GO:0030216","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0090263","count":4}]},{"hash":"1549415227792294540","title":"Cytoskeleton Dynamics and Cell Division Cluster","description":"This cluster centers on microtubule-based movement, mitotic sister chromatid cohesion, and Arp2/3 actin nucleation, highlighting cytoskeleton organization and cell division. Other terms like translation initiation and developmental/apoptotic processes appear, suggesting some proteins have broader roles, but the prevailing theme is cytoskeletal dynamics linked to mitosis and cellular movement.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0021510","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0007064","count":3},{"id":"GO:0007018","count":3}]},{"hash":"827769208670553884","title":"Neuronal signaling and sensory processing","description":"The top GO terms are dominated by neural-related functions (neuropeptide signaling, sensory perception of pain, visual learning, cellular response to temperature), with additional terms suggesting autonomic/metabolic regulation (thermogenesis, cardiac contraction) and some immune interactions (IL-8, chemokine production) that can tie to neuroendocrine-immune crosstalk. This points to a cluster centered on nervous system signaling and sensory processing, with secondary involvement of metabolic and immune regulation. While there are some disparate terms (thymocyte differentiation) that are less tightly linked, the neural theme is the strongest signal. ","confidence":"Medium","size":14,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0040015","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0002024","count":3}]},{"hash":"174505520047138555","title":"Neuronal signaling and circadian regulation","description":"The cluster\u2019s top GO terms are dominated by neural communication and circadian processes (startle response, cholinergic synaptic transmission, calcium ion import influencing excitability, and regulation of sleep/wake cycles), with additional neural-related terms like amyloid-beta formation and neuron survival. A couple of terms related to lipid A/LPS biosynthesis likely reflect annotation noise rather than a core function of these proteins. Overall, the theme centers on neural signaling and circadian regulation.","confidence":"Medium","size":14,"edges":18,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0045188","count":3},{"id":"GO:0009103","count":2},{"id":"GO:0009245","count":2}]},{"hash":"928767041332654913","title":"Ubiquitin-Mediated Proteostasis and ERAD","description":"This cluster is dominated by ubiquitination-related processes (K48- and K63-linked ubiquitination, autoubiquitination) along with related post-translational modifications (neddylation, sumoylation) and ER-associated degradation (ERAD), suggesting a cohesive role in protein quality control and proteostasis. Peroxisomal import and sporadic DNA repair signals appear as peripheral connections rather than core functions.","confidence":"High","size":14,"edges":44,"triangles":81,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0045116","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0016925","count":4},{"id":"GO:0070911","count":3}]},{"hash":"186431902086928933","title":"Amino acid transport and translation regulation","description":"The cluster combines translation-related processes (histidyl-tRNA aminoacylation, cytoplasmic translation, regulation of translational fidelity, selenocysteinyl-tRNA biosynthesis) with amino acid handling (amino acid transport across vacuolar membranes and response to amino acid availability). This suggests a theme where amino acid metabolism/transport is coordinated with protein synthesis, rather than an unrelated function. The solitary root cap development term appears to be an outlier and does not drive the overall theme.","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0048829","count":1},{"id":"GO:0006450","count":1},{"id":"GO:1903833","count":1},{"id":"GO:0006427","count":1},{"id":"GO:0097056","count":1}]},{"hash":"1700968716956456430","title":"Synapse assembly and presynaptic organization","description":"The GO terms are dominated by synapse-related processes\u2014synapse assembly, positive regulation of synapse assembly, presynaptic active zone assembly, and calcium-dependent cell\u2013cell adhesion\u2014pointing to a core theme of synaptogenesis and neural junction formation, with a few auxiliary terms seemingly less central.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":4},{"id":"GO:0043931","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0098911","count":3},{"id":"GO:0046328","count":3}]},{"hash":"2090082661233235966","title":"Neuronal Membrane Trafficking and Secretion","description":"The top terms point to neuronal signaling and vesicle-related processes (synaptic vesicle clustering, neurotransmitter secretion) and to membrane and ER targeting/ translocation, together highlighting the secretory pathway active in neurons. Behavioral terms like optomotor response and freezing align with neural signaling, while RNA processing and IRES-dependent translation reflect general gene-expression regulation in neurons. Overall, there is a cohesive theme around neuronal membrane trafficking and secretion, with some broader supporting terms.","confidence":"Medium","size":14,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050826","count":1},{"id":"GO:0030242","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0031204","count":1}]},{"hash":"846840390785593355","title":"ER quality control and innate immunity","description":"The top terms cluster around endoplasmic reticulum (ER)\u2013associated processes, including ERAD, ubiquitination, and tail-anchored membrane protein insertion, which point to ER quality control. The presence of innate immune/virus defense terms and TNF signaling suggests a link between ER protein handling and antiviral/inflammatory responses. Some terms about development (renal morphogenesis, axon guidance) appear as less representative outliers.","confidence":"Medium","size":14,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0033280","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0071816","count":2}]},{"hash":"1373539358961590746","title":"Meiosis-Linked DNA Repair and Recombination","description":"This cluster is dominated by GO terms related to meiotic processes and DNA repair: interstrand cross-link repair, double-strand break repair, meiotic mismatch repair, reciprocal recombination and gene conversion at loci like mating-type, and regulation of the cell cycle and germ cell development. These signals point to proteins participating in meiotic recombination and genome maintenance. A non-meiotic term (IgA isotype switching) is present but minor compared to the repair/recombination signals.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036297","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0048298","count":1},{"id":"GO:0007534","count":1},{"id":"GO:0007050","count":1}]},{"hash":"2250424415433264142","title":"Developmental differentiation and tissue morphogenesis","description":"The GO terms point to cell adhesion, cytoskeletal reorganization, and several differentiation and morphogenesis processes (myoblast differentiation, trophoblast giant cell differentiation, mononuclear cell migration, tube lumen cavitation, fibrinolysis remodeling). This suggests a theme of development-driven differentiation and tissue remodeling, with some incidental references to DNA replication that may reflect proliferative states in development. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0006260","count":1},{"id":"GO:0071897","count":1},{"id":"GO:0060707","count":1}]},{"hash":"1721333800191054580","title":"Embryonic heart development and morphogenesis","description":"The top GO terms point to heart development (heart development; endocardial cushion EMT) and left-right pattern formation, along with related embryonic morphogenetic processes, suggesting a focus on cardiovascular organogenesis during development. Some terms reference other tissues (placenta, endocrine organs, cartilage), which may reflect broader embryonic programs or annotation noise, but the heart-related terms provide the strongest cohesive theme.","confidence":"Medium","size":13,"edges":10,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048148","count":4},{"id":"GO:0060707","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060972","count":3}]},{"hash":"57218590852027086","title":"Spliceosome-Mediated mRNA Processing","description":"The terms cluster around splicing and other post-transcriptional mRNA processing steps (spliceosome-mediated splicing regulation, splice site recognition, mRNA export, stability, and translation regulation), indicating a module focused on spliceosome-driven mRNA maturation and export.","confidence":"High","size":13,"edges":34,"triangles":42,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":5},{"id":"GO:0006406","count":5},{"id":"GO:0006378","count":4},{"id":"GO:0048255","count":4}]},{"hash":"828227915927439321","title":"Brain Development and Neural Function","description":"The proteins in this cluster are mainly tied to neural and brain-related development, with terms like midbrain development, metencephalon development, inner ear development, brain development, and locomotory behavior pointing to neurodevelopment and neural activity. Pituitary gland development adds a neuroendocrine angle, while other terms (lipopolysaccharide response, cartilage development, endothelial barrier establishment) appear less central and may reflect broader developmental roles or secondary associations. Overall, the dominant theme is brain/neural development and function.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0022037","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0032496","count":3}]},{"hash":"798614029071710451","title":"Developmental signaling and immune cell migration","description":"This cluster centers on multiple signaling pathways tied to development and tissue formation (T cell receptor signaling, Roundabout/Robo, Hedgehog/Smoothened, nervous system and kidney development) alongside processes involving cell movement and cytoskeletal remodeling (mast cell chemotaxis, ruffle assembly). The inclusion of vesicle trafficking and PI3K regulation further supports a unifying theme of signaling networks coordinating development and immune cell motility.","confidence":"Medium","size":13,"edges":69,"triangles":201,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0035385","count":7},{"id":"GO:0007224","count":6},{"id":"GO:0001822","count":6}]},{"hash":"1759169996978602441","title":"Central carbon metabolism and redox regulation","description":"The top GO terms are dominated by central metabolic pathways (pyruvate and malate metabolism, L-malate catabolic process) and NADP-related redox regulation, suggesting energy production and redox balance as the core theme. Other terms\u2014mitochondrial tRNA modification, telomere maintenance, proteolysis, protein carbamoylation, protein tetramerization, and photosystem stoichiometry adjustment\u2014do not cohere into a single pathway, indicating a heterogeneous set of functions in this cluster. Therefore the label reflects the most represented functional axis, with some outliers.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072670","count":1},{"id":"GO:0000722","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0046944","count":1},{"id":"GO:0006090","count":1}]},{"hash":"1490607172250440243","title":"Unknown","description":"The top GO terms span apoptosis, plant developmental processes (pollen exine formation, shoot apical meristem regulation), erythrocyte differentiation, and various membrane transport activities, with no clear shared function linking all proteins. Given the heterogeneity and lack of edges, there isn\u2019t a cohesive theme to name the cluster beyond Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":1},{"id":"GO:0006309","count":1},{"id":"GO:0030218","count":1},{"id":"GO:0015739","count":1},{"id":"GO:1903857","count":1}]},{"hash":"1528375491469395337","title":"Neural synapse formation and axon guidance","description":"This cluster is enriched for GO terms tied to synapse assembly and maturation (and related protein complex assembly), as well as axon guidance and sensory processing features like inner ear receptor cell stereocilium organization and prepulse inhibition. The included terms point to roles in neural connectivity, synaptic development, and sensory signaling, with exosomal secretion reflecting intercellular communication. Overall, the dominant theme is neuronal synapse formation and connectivity.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0007411","count":2},{"id":"GO:2000821","count":1},{"id":"GO:0007416","count":1},{"id":"GO:1903543","count":1}]},{"hash":"61251806320028318","title":"Cytoskeletal Dynamics and Cell Migration Regulation","description":"The cluster centers on regulators of actin-driven protrusions and cell movement: lamellipodium and filopodium assembly, regulation of adhesion-dependent cell spreading and extravasation, and activation of GTPase signaling pathways (e.g., Rho/Ras) that modulate cytoskeletal remodeling. Negative regulation terms accompany a tuning of motility and barrier interactions, consistent with proteins that fine-tune movement rather than solely promote it. A midbrain morphogenesis term may reflect developmental roles tied to cytoskeletal changes. Overall, the theme is cytoskeleton dynamics linked to cell migration and adhesion. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0060304","count":2},{"id":"GO:0002692","count":2},{"id":"GO:0030032","count":2}]},{"hash":"204895369656961166","title":"GABAergic and Glycinergic Inhibitory Synapses","description":"This cluster is dominated by terms for GABA secretion and glycinergic synaptic transmission, with supporting amino acid transport terms (taurine, glycine, proline), pointing to inhibitory neurotransmission in the CNS. The presence of CNS development terms (thalamus development, motor neuron migration) suggests involvement in the formation or maturation of these inhibitory synapses. Overall, the set represents components of inhibitory synapses and related amino acid transport in neural tissue.","confidence":"High","size":13,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0014051","count":2},{"id":"GO:0097477","count":2},{"id":"GO:0042066","count":1},{"id":"GO:0060012","count":1},{"id":"GO:0051583","count":1}]},{"hash":"1698106208799998391","title":"Unknown","description":"The GO terms include lens development, cell adhesion, ECM remodeling, cytoskeleton assembly, hyaluronan metabolism, and germline RNA processing, with little overlap. There is no clear single function tying all proteins together, so a cohesive label is not supported.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0034113","count":1},{"id":"GO:0002089","count":1},{"id":"GO:1901202","count":1}]},{"hash":"107550368891671587","title":"Cytoskeletal Remodeling and Cell Migration","description":"The prevailing GO terms point to actin cytoskeleton dynamics: lamellipodium and filopodium assembly, cell migration, and regulation/activation of Rac and Ras GTPase signaling. This suggests the proteins collectively drive actin remodeling and movement. Some terms (e.g., IL-4 production, sensory perception of sound) seem tangential, but the dominant pattern centers on cytoskeletal regulation and motility.","confidence":"Medium","size":13,"edges":21,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":2},{"id":"GO:0045792","count":2},{"id":"GO:0032633","count":2},{"id":"GO:0035020","count":2},{"id":"GO:0030032","count":2}]},{"hash":"41296267303060668","title":"Mitochondrial Gene Expression and Respiration","description":"This cluster is dominated by mitochondrial-related terms: mitochondrial large ribosomal subunit assembly, mitochondrial RNA processing, and cellular respiration, suggesting a core theme of mitochondrial function. The other terms (differentiation, migration, and immune-related processes) appear sporadically and do not form a single cohesive function with the mitochondrial terms.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902775","count":1},{"id":"GO:0045333","count":1},{"id":"GO:0000963","count":1},{"id":"GO:0060707","count":1},{"id":"GO:1902042","count":1}]},{"hash":"389775067520867275","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000237","count":1},{"id":"GO:0006388","count":1},{"id":"GO:0000971","count":1},{"id":"GO:0016539","count":1},{"id":"GO:0006376","count":1}]},{"hash":"705888770263202903","title":"Epithelial morphogenesis and growth signaling","description":"GO terms point to epithelial development and growth control, featuring positive regulation of Wnt signaling and hippo signaling, keratinocyte differentiation, mammary gland branching morphogenesis, and processes linked to cell cycle and apoptosis. The mix of differentiation, proliferation, and morphogenetic pathways suggests a cluster of proteins coordinating epithelial tissue formation and size control.","confidence":"High","size":12,"edges":52,"triangles":126,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0046827","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0035329","count":5}]},{"hash":"960413029729494169","title":"Regulated vesicle trafficking and exocytosis","description":"Top terms point to intracellular transport processes: Rab signaling, vesicle docking in exocytosis, and regulation of vesicle size, with supporting hints from dendrite development and macrophage differentiation. The common thread is vesicle formation, targeting, and exocytosis across neural and immune contexts. A coherent label is thus \"Regulated vesicle trafficking and exocytosis.\"","confidence":"Medium","size":12,"edges":15,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030225","count":3},{"id":"GO:0071701","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0097494","count":2},{"id":"GO:1902570","count":2}]},{"hash":"1087728557077578298","title":"Lamellipodium Dynamics and Membrane Transporters","description":"The cluster is driven by lamellipodium assembly and regulation of Rho signaling, pointing to actin cytoskeleton remodeling involved in cell migration. The presence of multiple transmembrane transport terms (for nitrate, phosphate, sialic acid, fucose, vitamins, xenobiotics) suggests a set of membrane transport proteins. Together, these terms imply proteins that link cytoskeletal dynamics with membrane transport and trafficking, hence a label that captures both aspects.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0015739","count":2},{"id":"GO:0006004","count":2}]},{"hash":"339147610181801919","title":"Cell Polarity and Organelle Inheritance","description":"The top GO terms cluster around actin cortical patch assembly and cell polarity maintenance, plus inheritance of organelles (mitochondrion and vacuole) and cell-division\u2013related processes like the centrosome cycle and regulation of nuclear DNA replication. This points to a coordinated program of polarized growth and equal partitioning of organelles during division (likely budding yeast). Some obsolete chromatin remodeling terms appear but are not central to the main theme. ","confidence":"Medium","size":12,"edges":27,"triangles":32,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":4},{"id":"GO:0071963","count":4},{"id":"GO:0000001","count":4},{"id":"GO:0000011","count":4},{"id":"GO:0043486","count":4}]},{"hash":"1876525197344913782","title":"Actin Cytoskeleton & Sarcomere Assembly","description":"The cluster is enriched for GO terms centered on actin filament bundle assembly, actin cortical patch assembly, sarcomere organization, and skeletal muscle fiber development, with platelet aggregation reflecting actin-driven cytoskeletal rearrangements. Together these point to a cohesive theme of actin-based cytoskeleton organization and muscle structure formation, despite a few unrelated/obsolete terms present.","confidence":"Medium","size":12,"edges":39,"triangles":61,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":3},{"id":"GO:0070527","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0000147","count":2},{"id":"GO:0043486","count":2}]},{"hash":"2236368355184604770","title":"Unknown","description":"The top GO terms are highly diverse, including DNA replication, iron-sulfur cluster assembly, fungal cell wall biosynthesis, karyogamy, various stress- and apoptosis-related pathways, and even lung development. There isn\u2019t a single cohesive function that ties these proteins together, suggesting the cluster comprises proteins from multiple unrelated processes or a set with weak, non-specific associations. Therefore, I label it Unknown with no confidence in a representative function.","confidence":"","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":2},{"id":"GO:0006260","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0000742","count":1},{"id":"GO:0090084","count":1}]},{"hash":"433928452941951403","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":64,"triangles":201,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071042","count":3},{"id":"GO:0071051","count":3},{"id":"GO:0071038","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0006283","count":3}]},{"hash":"540800914736767865","title":"Nucleolar Ribosome Biogenesis and DNA Replication","description":"The top GO terms are dominated by ribosome biogenesis and rRNA processing (assembly of preribosome large subunit, maturation of LSU rRNA, ribosome biogenesis) along with nuclear DNA replication and cell cycle processes (DNA replication, centrosome cycle, regulation of nuclear DNA replication, transcription termination). This suggests a coherent theme centered on nucleolar ribosome production and coordination with the cell cycle. Some terms (viral genome replication, embryonic cranial skeleton morphogenesis, oxidative stress response) are less directly related and represent noise, but do not override the core ribosome/replication signal.","confidence":"Medium","size":12,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:1902626","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006369","count":2}]},{"hash":"1554788067505135747","title":"Transmembrane Transporters for Sugars, Ions, and Vitamins","description":"This cluster is dominated by GO terms for membrane transport of xenobiotics, sugars (fructose, glucose, trehalose), vitamins, phosphate, and potassium, indicating a cohesive set of transporter proteins that mediate uptake and ion/nutrient homeostasis across membranes. The diversity of substrates points to broadly acting solute carriers or related transporter families rather than a single substrate-specific pathway.","confidence":"High","size":12,"edges":9,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":8},{"id":"GO:0071805","count":7},{"id":"GO:0035461","count":7},{"id":"GO:0006855","count":7},{"id":"GO:0052106","count":5}]},{"hash":"1616263721626977408","title":"Ribosome biogenesis and translation","description":"The dominant GO terms are translation and ribosomal subunit/complex assembly, including small-subunit processome assembly, pointing to ribosome production and protein synthesis. Additional RNA processing and regulation terms (splice site recognition, mRNA modification, ncRNA-mediated gene silencing) align with RNA processing required for ribosome biogenesis and translational control, supporting a cohesive theme around ribosome assembly and translation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0006376","count":1},{"id":"GO:0016556","count":1},{"id":"GO:0031047","count":1}]},{"hash":"807007073065717026","title":"Autophagy and Post-Translational Modifications","description":"The top GO terms point to autophagy-related processes (cytoplasm-to-vacuole targeting, piecemeal microautophagy of the nucleus) and several post-translational modification pathways (neddylation, sumoylation, urmylation). This suggests a cohesive theme around cellular protein turnover and regulation via autophagy and protein modification, with a few more distant terms reflecting broader cellular processes. Overall, Autophagy and PTMs best captures the dominant signal with reasonable confidence.","confidence":"Medium","size":12,"edges":10,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032258","count":4},{"id":"GO:0045453","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0045116","count":3},{"id":"GO:0016925","count":3}]},{"hash":"560294305007803449","title":"Central carbon metabolism and biosynthesis","description":"The cluster\u2019s top GO terms center on biosynthetic processes (antibiotic, fatty acid, menaquinone biosynthesis) and core metabolic steps (TCA cycle, pyruvate decarboxylation to acetyl-CoA), indicating proteins involved in producing metabolites and generating energy. While there are a few terms related to translation and ion transport, the strongest signal is metabolic biosynthesis and energy metabolism, justifying a label focused on those functions.","confidence":"Medium","size":12,"edges":51,"triangles":110,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0010124","count":2},{"id":"GO:0006814","count":2}]},{"hash":"220914358329349968","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000237","count":1},{"id":"GO:0006388","count":1},{"id":"GO:0000971","count":1},{"id":"GO:0016539","count":1},{"id":"GO:0030968","count":1}]},{"hash":"1865604508656214841","title":"Innate Immune Signaling and Fibrinolysis Regulation","description":"This cluster is anchored by innate immune signaling, notably defense against Gram-positive bacteria and Toll pathway regulation, with additional signals of coagulation/fibrinolysis (plasminogen activation, fibrinogen regulation). While some developmental terms exist, the dominant theme is innate immune response intertwined with coagulation remodeling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0045752","count":1},{"id":"GO:0051919","count":1}]},{"hash":"185365469269789087","title":"Unknown","description":"The top GO terms are very diverse, including regulation of sumoylation, splicing, self proteolysis, sarcomere organization, muscle-related activation, development, and digestion. With no edges or functional coherence across terms, there isn\u2019t a single interpretable theme tying the proteins together. Therefore a generic Unknown label is most appropriate.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033234","count":2},{"id":"GO:0040039","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0097264","count":1},{"id":"GO:0045214","count":1}]},{"hash":"2293670043674180096","title":"Transcriptional and Immune Signaling Regulators","description":"This cluster centers on regulation of transcription by RNA polymerase II, immune signaling via Toll-like receptor pathways, and cell fate decisions (apoptosis, necroptosis, cell cycle), along with ubiquitination. The presence of developmental terms (lung development, embryo implantation) suggests these regulators influence development as well, likely through transcriptional and post-translational control of signaling pathways.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0034121","count":2},{"id":"GO:0060544","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0071157","count":2}]},{"hash":"1422987284028671164","title":"Developmental signaling and transcription regulation","description":"The terms cluster around developmental processes and signaling (dopamine receptor signaling, semaphorin-plexin, keratinocyte and pollen sperm development) combined with transcriptional control (DNA-templated transcription and RNA Pol I\u2013mediated regulation) and cytoskeletal dynamics (mitotic spindle assembly, actin depolymerization). This suggests a theme of regulation of gene expression and signaling during development, with supporting cytoskeletal changes, hence a developmental signaling and transcription regulation label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0007195","count":2}]},{"hash":"840951021021501017","title":"Viral Entry and Proviral Latency with Host Cell Cycle","description":"The top GO terms indicate viral entry and proviral latency processes (symbiont entry into host cell, viral penetration into host nucleus, establishment of integrated proviral latency, RNA-templated DNA biosynthetic process) alongside core cell-cycle and DNA replication activities (cell division, mitotic cell cycle, DNA replication). This points to a cluster of proteins involved in virus-host interactions that leverage host cell-cycle machinery for replication and latency, rather than a single cohesive cellular pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060271","count":3},{"id":"GO:0006260","count":3}]},{"hash":"977428494413009502","title":"Ubiquitin-Proteasome Regulation of Cell Cycle","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein degradation and polyubiquitination (including SCF-dependent proteasomal processes), plus links to DNA replication and cell-cycle checkpoint signaling (mitotic G1 DNA damage, meiotic recombination checkpoints) and apoptosis. The common thread is regulation of protein stability via the ubiquitin-proteasome system to control DNA replication and cell-cycle progression, with some immune-related signaling context in the mix. ","confidence":"High","size":12,"edges":9,"triangles":1,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0043029","count":3},{"id":"GO:0007114","count":3},{"id":"GO:0006260","count":3},{"id":"GO:1902916","count":3}]},{"hash":"814706522130264055","title":"Neuronal development and synaptic remodeling","description":"The Top Terms cluster around neuronal morphology and synaptic function: axon midline choice point recognition, dendrite development, axo-dendritic transport, neuron remodeling, and regulation of synapse structure or activity, plus a norepinephrine response suggesting neuronal signaling. Some terms (cholesterol metabolism, smooth ER Ca2+ homeostasis) are supportive of neuronal membranes and signaling but are less central to the core theme. Overall, the cluster points to neuronal development and synaptic remodeling rather than a single metabolic pathway.","confidence":"High","size":12,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0016199","count":1},{"id":"GO:0016322","count":1},{"id":"GO:0071874","count":1},{"id":"GO:0016358","count":1},{"id":"GO:0008203","count":1}]},{"hash":"1683816980259049371","title":"Mitochondrial respiration and lipid biosynthesis","description":"The top GO terms point to mitochondrial energy production (complex IV assembly, aerobic respiration, redox processes) and lipid metabolism (unsaturated fatty acid biosynthesis, sphingolipid metabolism, nitric oxide as a redox-related mediator). This suggests a cohesive theme around mitochondria-driven energy metabolism and lipid biosynthesis pathways, with a couple of tissue-specific terms (myelin maintenance, sebaceous gland differentiation) that may reflect specialized roles or annotation context. Overall, the cluster appears centered on mitochondrial function linked to lipid metabolism.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0009060","count":1}]},{"hash":"266720320736438264","title":"Lectin-mediated innate immunity","description":"This cluster is driven by terms related to fungal recognition and lectin-activated pathways: cellular response to molecule of fungal origin, complement activation via the lectin pathway, and stimulatory C-type lectin receptor signaling. While there are a few development-associated terms in the mix (metanephric and cartilage-related processes), the strongest signals center on lectin-mediated innate immune recognition and complement activation, suggesting a cohesive immune-focused theme with some pleiotropic annotations.","confidence":"High","size":12,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0072218","count":4},{"id":"GO:0072237","count":3},{"id":"GO:0090403","count":3}]},{"hash":"275239324490839330","title":"Developmental regulation and actin dynamics","description":"This cluster centers on GO terms related to development across tissues (neuron projection development, lens fiber differentiation, skeletal system development, multicellular organism development, cardiac muscle apoptotic process) and includes regulatory processes (DNA-templated transcription, regulation of kinase activity) plus cytoskeletal dynamics (positive regulation of Arp2/3 complex\u2013mediated actin nucleation). The common theme appears to be developmental programs coordinated with signaling and actin remodeling, despite some noisy terms like fungal-type cell wall biogenesis. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031175","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1570138624909868141","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0001755","count":2},{"id":"GO:0061053","count":2},{"id":"GO:0060445","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0001746","count":1}]},{"hash":"1760142332700504748","title":"Unknown","description":"There are no GO terms or interaction signals to define a shared function for this cluster (no edges, no enrichment, no terms). The ReCIPE note does not provide functional context, so a reliable label cannot be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1049625872917270155","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":11,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":4},{"id":"GO:0006986","count":4},{"id":"GO:0009408","count":3},{"id":"GO:0036494","count":3},{"id":"GO:0035719","count":2}]},{"hash":"843508475227145523","title":"Post-transcriptional RNA Processing and Translation Regulation","description":"The terms cluster around RNA fate after transcription: splicing and mRNA processing/modification, mRNA stability, and regulation of translation (initiation, reinitiation, and miRNA-mediated silencing). This points to a cohesive theme of post-transcriptional gene expression control and RNA metabolism.","confidence":"High","size":11,"edges":50,"triangles":126,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0045292","count":4},{"id":"GO:0048026","count":4}]},{"hash":"121417806469533732","title":"Developmental transcription and signaling regulators","description":"The terms cluster around transcriptional processes, DNA replication, and various developmental signaling/regulatory events (mesoderm formation, neural tube patterning, retinal axon guidance, hormone responses, and proteasomal regulation), suggesting a theme of coordinating development through transcriptional control and signaling pathways rather than a single concrete function.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0001707","count":2},{"id":"GO:0071374","count":2},{"id":"GO:1901621","count":2}]},{"hash":"519540064508073391","title":"Transcriptional Regulation and Differentiation","description":"The cluster shows enrichment for GO terms about negative regulation of transcription by RNA polymerase II and regulation of miRNA transcription, alongside various differentiation-related terms across multiple lineages (erythrocyte, megakaryocyte, lymphoid progenitor, goblet cell, mesenchymal/apoptotic processes). This pattern suggests a group of proteins that modulate gene expression programs to influence lineage differentiation, rather than a single tissue-specific function. Therefore, the label \"Transcriptional Regulation and Differentiation\" captures the dominant regulatory theme and the broad differentiation associations.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:1902895","count":1},{"id":"GO:0033600","count":1},{"id":"GO:0035855","count":1},{"id":"GO:0002320","count":1}]},{"hash":"1981133581898877384","title":"Neural development and synaptic plasticity","description":"The cluster is characterized by dendrite development and synapse structural plasticity, along with exploration behavior and positive regulation of GTPase activity, pointing to neuronal development and synaptic signaling as the core theme. Although there are terms spanning general cellular processes (mitotic cell cycle, tight junction assembly, Golgi localization, transcription), the neuronal-related terms are predominant, supporting a neural development/synaptic function label.","confidence":"Medium","size":11,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006470","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0035640","count":3},{"id":"GO:0035264","count":3}]},{"hash":"1966027887340758344","title":"Cytoskeleton remodeling and mitosis","description":"The top GO terms cluster around actin nucleation regulation (Arp2/3), mitotic spindle assembly, and chromosome segregation, pointing to cytoskeletal dynamics and cell division as a central theme, with additional periphery terms related to signaling, translation initiation, and development.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:2000601","count":4},{"id":"GO:0032995","count":4},{"id":"GO:0010659","count":4},{"id":"GO:0071902","count":4}]},{"hash":"950222039070703854","title":"Fungal Meiosis and Ascospore Formation","description":"The top terms cluster around meiotic processes (meiotic recombination checkpoint signaling), DNA replication, and ascospore formation, pointing to a fungal meiotic/sporulation program. Although several terms are labeled obsolete, the recurrent themes of meiosis and ascospore development suggest these proteins function together in fungal sexual reproduction and spore formation, with accompanying redox and apoptotic stress responses.","confidence":"Medium","size":11,"edges":7,"triangles":2,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090502","count":3},{"id":"GO:0070940","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0007568","count":2}]},{"hash":"1424857008317053748","title":"Guanylyl Cyclase Signaling and Telomere Regulation","description":"This cluster is driven by cGMP-related signaling: intracellular signal transduction, receptor guanylyl cyclase signaling, and cGMP biosynthesis. Telomere maintenance and capping regulation appear alongside transcription regulation, suggesting a signaling module that intersects with genome maintenance rather than a single, canonical pathway. Overall, a coherent theme around guanylyl cyclase/cGMP signaling with auxiliary telomere-related regulation emerges.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035556","count":5},{"id":"GO:1904355","count":4},{"id":"GO:0006355","count":4},{"id":"GO:0030828","count":4},{"id":"GO:0032212","count":4}]},{"hash":"987586755435168284","title":"Unknown","description":"The terms span muscle structure (thin filament assembly, myofibril size), development (pole cell formation, pole plasm localization), various translation-related processes (translational termination, mitochondrial translation, ribosomal subunit assembly), and even virus-related processes (ESCRT-mediated budding and release). There isn\u2019t a single cohesive function linking all proteins, so a meaningful cluster label cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071689","count":1},{"id":"GO:0007279","count":1},{"id":"GO:0071691","count":1},{"id":"GO:0045856","count":1},{"id":"GO:0014881","count":1}]},{"hash":"625737530944809882","title":"Meiotic recombination and DNA repair","description":"The Top Terms are dominated by meiotic processes and homologous recombination, including double-strand break repair via homologous recombination, meiotic DNA recombinase assembly, joint molecule formation, and mating-type related events. While an antigen processing term appears, the strongest signal centers on meiosis and DNA repair machinery, supporting a label focused on meiotic recombination functions.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071479","count":1},{"id":"GO:0007534","count":1},{"id":"GO:0000709","count":1},{"id":"GO:0042148","count":1},{"id":"GO:0043388","count":1}]},{"hash":"2048325083024046485","title":"Unknown","description":"Top terms span photosynthesis and chlorophyll biosynthesis alongside development (gonads, cochlea, root meristem) and chromatin/replication terms, which do not form a coherent single-function cluster. There is no clear, representative function tying these proteins together.","confidence":"","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0030466","count":4},{"id":"GO:0008584","count":3},{"id":"GO:0007292","count":3},{"id":"GO:0015979","count":3},{"id":"GO:0006279","count":3}]},{"hash":"1737463670555437464","title":"Neuronal Development and Synaptic Function","description":"Based on the top GO terms, the cluster is enriched for neural development and synaptic activity, including dendrite development, excitatory postsynaptic potential, and forebrain radial glial differentiation, as well as a behavioral fear response. Additional terms reflect general gene expression processes (DNA-templated transcription) and ribosome biogenesis, suggesting active transcriptional and translational activity in developing neural cells. Collectively, the dominant neural development and synaptic function terms support a label focused on neuron development and connectivity.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016358","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0021861","count":2},{"id":"GO:0001662","count":2},{"id":"GO:0006351","count":2}]},{"hash":"790501219747507101","title":"Virus entry and replication machinery","description":"This cluster centers on viral processes: virion assembly, viral life cycle, and membrane fusion with host cells, plus host-entry terms like symbiont entry into host. While some terms reflect general host functions (RNA splicing, protein folding) that can be hijacked during infection, the dominant signal is virus\u2013host interaction and steps of viral replication/assembly, justifying the label. ","confidence":"High","size":10,"edges":42,"triangles":98,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0019068","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0000245","count":3},{"id":"GO:0071492","count":2},{"id":"GO:0019058","count":2}]},{"hash":"1923298801012167206","title":"H/ACA snoRNPs and telomerase RNA processing","description":"The top GO terms cluster around box H/ACA snoRNP assembly, snoRNA-guided pseudouridylation of rRNA and snRNA, and telomerase RNA processing (localization, stabilization, and holoenzyme assembly). While ribosome biogenesis and SRP-related translation terms appear, the strongest signal is the snoRNP/telomerase RNA processing pathway, making this label representative of the cluster\u2019s core function.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006616","count":1},{"id":"GO:0045900","count":1},{"id":"GO:0006614","count":1},{"id":"GO:0042254","count":1},{"id":"GO:1905323","count":1}]},{"hash":"736082547117134645","title":"Vertebrate development and tissue differentiation","description":"The top GO terms mostly reflect organ and tissue development\u2014heart, bone (ossification), kidney (metanephric tubule development), and multicellular organism development\u2014suggesting proteins involved in developmental programs and tissue formation; a few terms touch nervous system function and stress responses, but development is the unifying theme. ","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043065","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0000272","count":3},{"id":"GO:0007269","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1883750802016553503","title":"Skin and lens development with actin signaling","description":"This cluster highlights developmental processes, especially skin development and lens fiber differentiation, alongside cell proliferation and cycle regulation. The presence of actin cytoskeleton regulation (Arp2/3) and signaling modulation (kinase activity, GTPase, phosphorylation) suggests coordinated morphogenesis with cytoskeletal dynamics during epidermal and lens differentiation, supported by associated mRNA transport.","confidence":"Medium","size":10,"edges":7,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0070306","count":5},{"id":"GO:2000601","count":4},{"id":"GO:0071902","count":4}]},{"hash":"735388026231636235","title":"Synaptic vesicle trafficking and transmission","description":"Most top terms cluster around vesicle trafficking and synaptic function: ER-Golgi transport, COPII vesicle coating, regulation of synaptic vesicle exocytosis and endocytosis, and excitatory postsynaptic potential, with a neuron-specific hint from substantia nigra development. This points to proteins involved in neuronal vesicle trafficking and synaptic transmission rather than general cell-cycle or metabolic processes.","confidence":"Medium","size":10,"edges":5,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:2000300","count":3},{"id":"GO:0010458","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0060079","count":3}]},{"hash":"865343837074446830","title":"RNA Processing and Translational Regulation","description":"Proteins in this cluster are enriched for RNA-focused functions: mRNA splice site recognition, mRNA modification and polyadenylation, regulatory ncRNA-mediated gene silencing, regulation of translational initiation, and small-subunit processome assembly. The inclusion of oskar mRNA localization further supports a link to RNA localization as part of post-transcriptional regulation. Overall, the group appears to represent a module coordinating RNA processing and translation control, with a few peripheral terms reflecting broader RNA regulatory roles.","confidence":"Medium","size":10,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":2},{"id":"GO:0016556","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0006446","count":2}]},{"hash":"516179595769550496","title":"Mitochondrial dynamics and telomere-regulated cell cycle","description":"This cluster centers on mitochondrial membrane fission and telomere maintenance (capping and telomerase), alongside cell cycle and apoptotic processes, suggesting a coordinated module of mitochondrial dynamics and telomere\u2011linked regulation of proliferation under stress. Some terms (e.g., adipogenesis and migration) point to broader developmental contexts but are less central to the core theme.","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034198","count":3},{"id":"GO:0000002","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0090149","count":3},{"id":"GO:1904355","count":2}]},{"hash":"405288259957429985","title":"Cellular maintenance and remodeling","description":"The terms span core growth processes (DNA replication, translational initiation) and key maintenance pathways (autophagosome maturation, SNARE/disassembly, microtubule dynamics, SCF complex regulation, oxidative phosphorylation), pointing to general cellular homeostasis, turnover, and trafficking rather than a single specific pathway. This suggests a cluster of proteins involved in basic cell maintenance and remodeling activities.","confidence":"Medium","size":10,"edges":11,"triangles":3,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006413","count":3},{"id":"GO:0051260","count":2},{"id":"GO:1903007","count":2},{"id":"GO:1903862","count":2}]},{"hash":"1349807552047119392","title":"Ubiquitin-regulated NF-kB/TNF inflammatory signaling","description":"This cluster centers on GO terms involving NF-kappaB activation, TNF-mediated signaling, JNK cascade regulation, and ubiquitin-dependent protein turnover. These together point to inflammatory signaling pathways that are modulated by ubiquitination, with some terms being obsolete but not changing the core theme. The proteins likely participate in NF-kB and TNF-related signaling and related ubiquitin-mediated regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0051865","count":1},{"id":"GO:2000620","count":1},{"id":"GO:0009048","count":1}]},{"hash":"29648062581677046","title":"Translation initiation and ribosome assembly","description":"The terms cluster around core protein synthesis machinery: formation of translation initiation complex, cytosolic ribosome assembly, translation, and preinitiation complex formation, indicating a cohesive function in initiating and assembling ribosomes for protein synthesis. A couple of outliers (ovarian follicle development and male germ cell proliferation) appear incidental to this dominant theme. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001732","count":1},{"id":"GO:0042256","count":1},{"id":"GO:1905618","count":1},{"id":"GO:0006413","count":1},{"id":"GO:1905537","count":1}]},{"hash":"2000554322012188550","title":"Rac-Mediated Actin Protrusions and Migration","description":"The cluster is dominated by GO terms tied to actin cytoskeleton remodeling and cell movement: lamellipodium and filopodium assembly, cell migration, and Rac/GTPase signaling. This suggests a cohesive theme of Rac-regulated actin-based protrusions driving motility, with supporting hints from Ras signaling modulation; a few unrelated terms appear but do not dominate the signal. High confidence that the label reflects the core function of the cluster.","confidence":"High","size":10,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0006348","count":4},{"id":"GO:0032633","count":3},{"id":"GO:0035020","count":3},{"id":"GO:0030032","count":3}]},{"hash":"1454907217279372746","title":"NF-kB/TNF inflammatory signaling with ubiquitination","description":"This cluster centers on NF-kappaB activation and TNF-mediated signaling, with supporting roles for ubiquitin-dependent protein degradation and autoubiquitination, suggesting a cohesive immune/inflammatory signaling module modulated by ubiquitination. Some obsolete or peripheral GO terms appear, but the core theme connects inflammatory signaling pathways (NF-kB, JNK, TNF) and ubiquitin regulation.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0051865","count":1},{"id":"GO:2000620","count":1},{"id":"GO:0009048","count":1}]},{"hash":"820800181820010812","title":"Organogenesis and Nervous System Development","description":"This cluster centers on developmental processes across multiple tissues (aorta morphogenesis, collecting duct and distal tubule development, trigeminal nerve and sympathetic nervous system development, male gonad development) with additional neuronal survival terms, suggesting a broad theme of organogenesis and nervous system development rather than a single, specific function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":1},{"id":"GO:0035909","count":1},{"id":"GO:0008584","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0043525","count":1}]},{"hash":"920793497589763914","title":"Nervous system development and axon guidance","description":"The cluster is dominated by terms related to nervous system development, peripheral nervous system development, axon guidance, and regulation of synapse assembly, with supporting terms like cell adhesion. The presence of Roundabout (Robos) and Smoothened (Hedgehog) signaling terms further supports roles in axon pathfinding and neural patterning, suggesting a cohesive theme around neural wiring and synapse formation during development.","confidence":"High","size":10,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007422","count":2},{"id":"GO:0048598","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0051963","count":2},{"id":"GO:0007155","count":2}]},{"hash":"601193812920640265","title":"Ribosome biogenesis and RNA transcription","description":"The cluster is dominated by GO terms for ribosome biogenesis and RNA transcription (RNA-templated transcription, transcription by RNA polymerase II and III, and tRNA transcription by RNAP III), with additional related transcription elongation terms. This suggests a cohesive set of proteins involved in gene expression machinery and ribosome assembly. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0001172","count":2},{"id":"GO:0042797","count":2},{"id":"GO:0006508","count":1},{"id":"GO:0006559","count":1}]},{"hash":"738209394779499842","title":"Chromatin Remodeling and Heterochromatin Formation","description":"The top GO terms cluster around chromatin organization, heterochromatin formation (including rDNA and pericentric regions), nucleus organization, and transcription regulation via chromatin remodeling. While some terms touch on development or cell migration, the common theme is chromatin state control influencing transcription and nuclear structure, making this label a coherent representation of the group.","confidence":"Medium","size":9,"edges":17,"triangles":14,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0045815","count":4},{"id":"GO:0007549","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0071674","count":3}]},{"hash":"35800159815308876","title":"Far-Red Light Signaling and Circadian Regulation","description":"This cluster is enriched for phototransduction and circadian-related GO terms (far-red light signaling pathway, red/far-red phototransduction, positive regulation of circadian rhythm) and transcription regulation, suggesting a light-responsive, circadian regulatory module. Some unrelated terms appear, but the dominant theme is light signaling and circadian control.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0009585","count":2},{"id":"GO:0042753","count":2},{"id":"GO:0010018","count":2}]},{"hash":"1292195491071219807","title":"Eye and neural development","description":"The cluster is dominated by terms related to eye development (retina development, embryonic eye morphogenesis) and neural organization (neurexin clustering, synaptic vesicle clustering), pointing to proteins involved in eye formation and nervous system connectivity. Some terms (lipid catabolic process, gibberellic acid signaling) are less aligned, but do not override the clear eye/neuronal theme.","confidence":"High","size":9,"edges":25,"triangles":25,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":4},{"id":"GO:0002076","count":4},{"id":"GO:0002087","count":4},{"id":"GO:0060041","count":4},{"id":"GO:0048048","count":4}]},{"hash":"722329098844497792","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by ribosomal large subunit assembly and translation, pointing to a core role in protein synthesis. Other terms hint at broader cellular growth and trafficking contexts (Golgi retention, peroxisome import, cell division, centriole elongation), but the strongest shared function across the cluster is ribosome assembly and active protein synthesis.","confidence":"Medium","size":9,"edges":26,"triangles":41,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0006412","count":2}]},{"hash":"1186953911437904103","title":"Kinase signaling and mitosis control","description":"The cluster is dominated by GO terms related to kinase regulation and cell division: both positive and negative regulation of protein kinase activity, serine/threonine kinase activity and autophosphorylation, along with mitotic cell cycle and positive regulation of cell proliferation. While a couple terms (tRNA import, hypoxia response) are less directly connected, the prevailing signal ties to kinase-driven signaling that governs mitosis and proliferation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0071902","count":2},{"id":"GO:0043547","count":2}]},{"hash":"789336086499276397","title":"Ubiquitin-mediated degradation and autophagy","description":"The top GO terms point to ubiquitin-dependent protein turnover, including autoubiquitination, ERAD, and aggrephagy, plus regulation of autophagosome maturation and endocytic processes. Together these suggest a cohesive theme of protein quality control via ubiquitin tagging and autophagy/ERAD pathways, with some regulatory links to trafficking and signaling.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0051865","count":9},{"id":"GO:0070911","count":9},{"id":"GO:0030433","count":9},{"id":"GO:0035973","count":6},{"id":"GO:1903071","count":6}]},{"hash":"301935260473561830","title":"Unknown","description":"No shared functional terms are listed, and the graph is only sparsely connected (Edges: 2, Max Degree: 2) for 9 proteins. Without GO terms to tie the members to a common process or function, I cannot infer a coherent theme. Thus, the cluster is labeled Unknown.","confidence":"","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"721872374738144349","title":"Neural signaling and ion transport","description":"Top GO terms indicate neuronal communication via GABA signaling, excitatory postsynaptic potentials, locomotory behavior, and conditioned taste aversion, together with sodium/potassium ion transmembrane transport. This points to proteins involved in synaptic signaling and ion channel function, supporting the label. A few outlier terms (e.g., actin nucleation, fungal cell wall biogenesis, cardiac apoptotic processes) may reflect multifunctionality or annotation noise, but the dominant theme is neural signaling and ion transport.","confidence":"Medium","size":9,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0007214","count":2},{"id":"GO:0001661","count":2}]},{"hash":"2139617811838560850","title":"Transcriptional Regulation and RNA Processing","description":"The cluster is enriched for DNA-templated transcription, mRNA processing, and regulation of transcription by RNA polymerase II, indicating core transcriptional control roles. While terms like heart development and thyroid hormone metabolism appear, the dominant theme is gene expression regulation, justifying a transcription/processing label.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006397","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1820487820102384413","title":"Mitochondrial Translation and Redox Regulation","description":"This cluster is driven by translation-related GO terms (tRNA processing and translation) and is reinforced by mitochondrial functions (respiratory chain complex IV assembly, cytochrome-c oxidase activity) along with redox-associated processes (oxidative stress response, deglutathionylation). Together, they suggest proteins involved in protein synthesis with mitochondrial redox regulation.","confidence":"Medium","size":9,"edges":23,"triangles":28,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0033132","count":1},{"id":"GO:1904960","count":1},{"id":"GO:0008535","count":1}]},{"hash":"2102907586342270245","title":"Developmental growth and vesicle trafficking","description":"These proteins show a theme of developmental progression and cell proliferation (multicellular organism growth, brain development, cell population proliferation, mitotic cell cycle) together with intracellular transport and protein processing (formation of translation preinitiation complex, translation reinitiation, COPII vesicle budding, ER\u2013Golgi and Golgi\u2013ER transport). The combination suggests roles in coordinating growth with secretory pathway trafficking during development, including brain development. Confidence: Medium","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0090114","count":2}]},{"hash":"1477140903835278947","title":"Vacuolar amino acid transport","description":"The cluster centers on transmembrane transport into/out of the vacuole for multiple amino acids (lysine, arginine, tyrosine, proline, alanine) and some ions, pointing to a shared role as vacuolar transporters. The GO terms emphasize import/export across the vacuolar membrane, supporting a cohesive function in amino acid (and related ion) homeostasis within the vacuole.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048829","count":1},{"id":"GO:1990818","count":1},{"id":"GO:0090517","count":1},{"id":"GO:0090452","count":1},{"id":"GO:1901481","count":1}]},{"hash":"2033715016442028892","title":"Unknown","description":"The GO terms span plant hormone response, insect development, cuticle pigmentation, muscle stretch response, miRNA transcription, neural development, and growth factor regulation, with no clear, cohesive biological theme tying the proteins together. As a result, a single representative label cannot be assigned with confidence. ","confidence":"","size":8,"edges":8,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009737","count":1},{"id":"GO:0033687","count":1},{"id":"GO:0046529","count":1},{"id":"GO:0048085","count":1},{"id":"GO:0035994","count":1}]},{"hash":"535669568846280405","title":"Vacuolar amino acid transport","description":"Top GO terms largely point to transmembrane transport of amino acids like arginine, lysine, and glutamine across vacuolar membranes, with a few related ion transport terms. This pattern suggests a theme of vacuolar nutrient movement in plant cells. Some terms are unrelated or obsolete, but the shared emphasis on vacuolar amino acid transport supports this cluster label.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048829","count":1},{"id":"GO:1903427","count":1},{"id":"GO:0051085","count":1},{"id":"GO:1990818","count":1},{"id":"GO:1904874","count":1}]},{"hash":"382803594817793384","title":"Nuclear RNA processing and transcription regulation","description":"The terms point to functions in the nucleus coordinating RNA polymerase II transcription (termination, open complex formation), RNA processing and splicing (spliceosome regulation and conformational changes, mRNA catabolism), and ncRNA-mediated silencing, with some chromatin regulation and stress-related responses (UV protection, cold response) as ancillary themes. Together, they suggest a cluster of proteins involved in transcriptional control and RNA processing within the nucleus.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006369","count":6},{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0071042","count":4},{"id":"GO:0001113","count":4}]},{"hash":"1209636577094509700","title":"Embryonic and tissue development","description":"The top GO terms cluster around development of various tissues and organs (spinal cord, forebrain, skeletal system, skin, embryonic organs, seminiferous tubules), with a note on cell proliferation (DNA replication) typical of growth during development. This suggests the proteins collectively participate in broad developmental processes across multiple tissues.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0021510","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0007568","count":2}]},{"hash":"646034507846558235","title":"Ubiquitin-Dependent Signaling Regulators","description":"Top terms point to ubiquitination and regulation of signaling pathways (Wnt, JNK, TNF); multiple annotations for K63- and K6-linked ubiquitination, ubiquitin-dependent proteolysis, and autoubiquitination suggest these proteins function as ubiquitin-mediated modulators of signaling.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0046328","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0051865","count":2}]},{"hash":"2018834254095203021","title":"Dynamic protein complex remodeling and autophagy","description":"The terms cluster around assembly/disassembly of protein complexes (SCF, SNARE), autophagosome maturation, cytoskeletal dynamics, and metabolic regulation, pointing to a theme of remodeling cellular machinery and trafficking rather than a single linear pathway. Some terms appear peripheral (e.g., blastocyst development, leading strand elongation), but the dominant signal is dynamic protein complex turnover and autophagy-related processes.","confidence":"Medium","size":8,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:1903007","count":3},{"id":"GO:1903862","count":3},{"id":"GO:1990171","count":3},{"id":"GO:0030420","count":3}]},{"hash":"812640045116347482","title":"ECM adhesion and remodeling","description":"The proteins cluster around extracellular matrix interactions and cell adhesion, including heterotypic and calcium-independent cell\u2013matrix adhesion, ECM assembly regulation, and hyaluronan metabolism, with links to cartilage/tissue development and cell movement (extravasation). Some terms (complement activation, proteasome assembly) are less connected but may reflect broader cellular maintenance; overall, ECM\u2013adhesion dynamics appear to dominate. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034113","count":1},{"id":"GO:1901202","count":1},{"id":"GO:0007161","count":1},{"id":"GO:0048455","count":1},{"id":"GO:0035987","count":1}]},{"hash":"904944103749929045","title":"Embryonic Development and Tissue Morphogenesis","description":"This cluster is dominated by GO terms tied to development and morphogenesis across multiple tissues (angiogenesis, embryonic body morphogenesis, myoblast differentiation, vestibular receptor morphogenesis, salivary gland boundary specification, prostate gland development, and mesenchymal-epithelial signaling). Together they point to a general theme of tissue formation and differentiation during development. An outlier term on neurofibrillary tangle assembly is noted but does not change the overall interpretation.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0042698","count":3},{"id":"GO:0007432","count":3},{"id":"GO:1902997","count":3},{"id":"GO:0010172","count":3}]},{"hash":"1335935889901084997","title":"Telomere maintenance and genome stability regulation","description":"The top GO terms point to telomere capping/maintenance and DNA repair, with supporting roles in transcription and mRNA processing, suggesting a core function in genome integrity and regulation of gene expression.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1904355","count":3},{"id":"GO:0032212","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0006281","count":3}]},{"hash":"1794358615772231620","title":"Translation and tRNA charging","description":"The cluster is dominated by translation-related GO terms (cytoplasmic translation, translation, histidyl-tRNA aminoacylation, regulation of translational fidelity), pointing to a core function in protein synthesis and tRNA charging. A few peripheral terms (selenocysteine biosynthesis, embryo development, electron transport) appear ancillary and do not define the main theme. Confidence reflects this overall translation-centric pattern.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0006450","count":1},{"id":"GO:1903833","count":1},{"id":"GO:0006427","count":1},{"id":"GO:0097056","count":1}]},{"hash":"1575958194853686152","title":"Retroviral integration and transposon activity","description":"This cluster centers on GO terms for viral entry, proviral latency, DNA integration, and transposition (DNA transposition, retrotransposition, RNA-templated DNA biosynthesis), pointing to retroviral/retroelement activity as the shared function. A few terms (trophoblast giant cell differentiation) are less directly related but may reflect broader developmental roles of endogenous retroelements.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"666799675920863782","title":"Central carbon metabolism and respiration","description":"The proteins are linked to glycolysis, the TCA cycle, mitochondrial electron transport, anaerobic respiration, redox homeostasis, thiamine biosynthesis, and glycerol catabolism, pointing to central energy metabolism. Some terms such as neuron maturation and erythrocyte differentiation appear incidental. ","confidence":"High","size":8,"edges":16,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0009228","count":2},{"id":"GO:0006121","count":2}]},{"hash":"1321339881730684047","title":"Protein N-terminal and histone acetylation cluster","description":"The top GO terms are dominated by acetylation-related processes across substrates (N-terminal serine/methionine/lysine acetylation, spermidine acetylation, N-acetylglucosamine metabolism) and a chromatin-related term (subtelomeric heterochromatin formation). This points to a cohesive theme of acetyltransferase activity and chromatin regulation via acetylation, even if a few unrelated terms appear in the list. ","confidence":"Medium","size":8,"edges":24,"triangles":34,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0017198","count":5},{"id":"GO:0061606","count":5},{"id":"GO:0006044","count":5},{"id":"GO:0006348","count":5},{"id":"GO:0043967","count":5}]},{"hash":"2265290463844730644","title":"Ubiquitin-Mediated Protein Quality Control","description":"The terms are dominated by ubiquitin-dependent degradation, polyubiquitination, and ER-associated degradation, pointing to the ubiquitin-proteasome system and protein quality control. Additional signals for unfolded protein response and stress from UV-A or cadmium further support a role in managing misfolded or damaged proteins, with some antiviral/immune-context terms likely reflecting broader stress signaling. This cohesive theme fits a single functional cluster of ubiquitin-mediated proteostasis and ERAD.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0006986","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0050689","count":1}]},{"hash":"1317485719680897693","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by translation and ribosome-related processes (translation; cytosolic ribosome assembly; ribosomal large subunit biogenesis; rRNA processing), indicating a cluster of proteins involved in ribosome assembly and protein synthesis. The additional stress-related terms and the solitary metabolic/autophagy term appear as minor associations, not changing the central theme. Therefore, the cluster most likely represents components of the ribosome biogenesis and translation machinery.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0051298","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0042256","count":1}]},{"hash":"1930957262833296482","title":"Steroid, lipid, and antibiotic biosynthesis","description":"The top GO terms center on diverse biosynthetic pathways\u2014testosterone biosynthesis (steroids), sphingolipid and very long-chain fatty acid biosynthesis, poly-hydroxybutyrate biosynthesis, phylloquinone metabolism, and antibiotic biosynthesis/response\u2014suggesting a cluster enriched for broad metabolite biosynthesis rather than a single, narrow function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0006355","count":4},{"id":"GO:0031427","count":3},{"id":"GO:0030148","count":3}]},{"hash":"15803689857737593","title":"Developmental Differentiation and Mineralized Tissue Formation","description":"These GO terms cluster around developmental processes (multicellular development, endodermal differentiation, wound healing, cadherin-mediated adhesion) and transcriptional regulation, with strong hints of mineralized tissue formation (amelogenesis and intramembranous ossification). Together they paint a coherent theme of tissue morphogenesis and enamel/bone formation during development, even though some terms are more general to development and remodeling. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001955","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0044331","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0032026","count":2}]},{"hash":"11670706296404186","title":"Metabolic Biosynthesis and Metal Transport","description":"The top GO terms span diverse biosynthetic and metabolic processes (lipopolysaccharide biosynthesis, carbohydrate and N-acetylglucosamine biosynthesis, phospholipid turnover, various catabolic processes) together with metal ion transport (zinc and copper) and a P450 epoxygenase pathway, plus an outlier: response to testosterone. This pattern points to a cluster focused on broad biosynthetic/metabolic activity and ion transport, rather than a single tightly defined function; testosterone response may reflect incidental annotation rather than a core theme. ","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":3},{"id":"GO:0033574","count":2},{"id":"GO:0019373","count":2},{"id":"GO:0071577","count":2},{"id":"GO:0005975","count":2}]},{"hash":"925984769766991782","title":"Neuronal neurotransmitter transport and amino acid sensing","description":"The top GO terms converge on neuronal communication (neurotransmitter transport, regulation of neurotransmitter secretion, synaptic plasticity) and responses to amino acid availability or stimulus, along with membrane transport activities. This suggests a cluster of proteins that link neurotransmission with amino acid sensing and metabolic signaling in neurons or neuroendocrine contexts.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007612","count":2},{"id":"GO:0006817","count":2},{"id":"GO:0034198","count":2},{"id":"GO:0071230","count":2},{"id":"GO:2000378","count":2}]},{"hash":"1288991439985308670","title":"Viral entry and genome integration into host","description":"This cluster\u2019s terms cluster around viral-host interactions: symbiont/viral entry into host cells, establishment of proviral latency, viral penetration into the host nucleus, and DNA integration, recombination, and RNA-templated DNA biosynthesis. While a few terms relate to general DNA replication, the core theme is viral genome entry and integration into the host, suggesting a cohesive, albeit narrow, functional signal. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033601","count":2},{"id":"GO:0006260","count":1},{"id":"GO:0006278","count":1},{"id":"GO:0046718","count":1},{"id":"GO:1903704","count":1}]},{"hash":"434885892287783922","title":"Chromatin organization and transcription regulation","description":"The GO terms cluster around nuclear and chromatin processes: negative regulation of transcription by RNA polymerase II, heterochromatin formation (rDNA and pericentric), and nucleus organization, with dosage compensation indicating chromatin state control. Some development/migration terms appear, but the strongest signal is chromatin organization and transcription regulation.","confidence":"Medium","size":7,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0007549","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0071674","count":5},{"id":"GO:0000183","count":5}]},{"hash":"328537167798193975","title":"Synapses and auditory hair cell components","description":"Top terms indicate a strong focus on synapse assembly and presynaptic active zone assembly, along with inner ear receptor cell stereocilium organization and sensory perception of sound. Although there are some broader developmental terms present, the core signal points to neural synapses and auditory hair cell structures, justifying the label. ","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":1},{"id":"GO:0045216","count":1},{"id":"GO:0048105","count":1},{"id":"GO:1904071","count":1},{"id":"GO:0016339","count":1}]},{"hash":"1348451793389321027","title":"Cell Cycle and Chromosome Segregation","description":"The top GO terms cluster around cell cycle and chromosome handling: meiotic cell cycle, G1/S transition, DNA replication, kinetochore localization, and mitotic centrosome separation, pointing to core cell cycle machinery. While other terms touch neuronal development or immune signaling, the strongest signal is DNA replication and chromosome segregation, justifying this label.","confidence":"High","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":7},{"id":"GO:0051321","count":7},{"id":"GO:0000082","count":7},{"id":"GO:0042220","count":7},{"id":"GO:0014044","count":7}]},{"hash":"1151155226766386855","title":"Unknown","description":"The top GO terms span meiosis, fungal sporulation, apoptosis signaling, cell adhesion, miRNA processing, neuronal signaling, metabolism, and tissue differentiation, with no single cohesive function tying the proteins together. This broad, mixed set suggests no clear shared theme beyond general cellular processes.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072462","count":7},{"id":"GO:2001241","count":7},{"id":"GO:0030437","count":7},{"id":"GO:0098609","count":7},{"id":"GO:1903799","count":7}]},{"hash":"1820153706268541546","title":"Developmental and neural morphogenesis","description":"The GO terms point to broad embryonic development across multiple tissues (digits, bronchioles, spleen, uterus, metanephros) with a strong emphasis on nervous system development (PNS neuron development, regulation of axon extension, trochlear nerve formation), suggesting a cluster of developmental processes with neural morphogenesis as a prominent theme.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0042733","count":2},{"id":"GO:0060435","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0060065","count":2}]},{"hash":"1437661108266003194","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0042787","count":1},{"id":"GO:0035719","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0032781","count":1}]},{"hash":"133385632864115787","title":"Nucleolar Transcription and Ribosome Biogenesis","description":"The top GO terms strongly point to activities in the nucleolus and ribosome production: ribosome biogenesis, nucleolar rRNA transcription by RNA polymerase I, plus transcription by RNA polymerases II and III, and nucleologenesis. These indicate a shared function around nucleolar transcription and assembly of ribosomes. Some broader terms (e.g., circadian regulation of translation) may reflect related regulatory layers, but do not outweigh the core theme. Overall, a coherent label is nucleolar transcription coupled to ribosome biogenesis.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0042790","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0017126","count":1},{"id":"GO:0001172","count":1}]},{"hash":"1498004439249814285","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006189","count":1},{"id":"GO:0006740","count":1},{"id":"GO:0015992","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0019878","count":1}]},{"hash":"312615450781257505","title":"APC/C-Mediated Ubiquitination in Mitosis","description":"The top GO terms point to mitotic control and protein degradation via ubiquitin, notably mitotic cell cycle, anaphase-promoting complex-dependent catabolic process, cell division, and ubiquitin-dependent protein catabolic processes, with K11-linked ubiquitination specifically highlighted. This combination strongly suggests proteins involved in APC/C-driven ubiquitin tagging for mitotic proteolysis, despite some obsolete or peripheral terms present. Overall, a coherent theme is proteolysis-regulated mitosis via ubiquitination.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070979","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0071276","count":2},{"id":"GO:2001162","count":2}]},{"hash":"1823883171480912885","title":"ER Protein Folding and Oxidative Stress Response","description":"This cluster centers on ER-associated functions: protein folding in the endoplasmic reticulum and retention of proteins in the ER lumen, coupled with oxidative stress handling (deglutathionylation and redox regulation). While some transcription-related terms appear, the strongest signals point to ER quality control and redox regulation, with a possible link to apoptosis signaling under oxidative stress.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0034599","count":1},{"id":"GO:1903206","count":1}]},{"hash":"2077299459169478352","title":"GABAergic Synaptic Function and Neural Behavior","description":"The cluster is enriched for neuronal signaling terms, notably synaptic vesicle maturation and gamma-aminobutyric acid (GABA) secretion, and behavioral terms such as grooming and locomotory exploration, indicating a core role in neuronal communication and behavior; the other terms about adherens junctions, myelin, and barriers may reflect related tissue contexts but are less central.","confidence":"Medium","size":7,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000821","count":1},{"id":"GO:0071896","count":1},{"id":"GO:0035641","count":1},{"id":"GO:0016188","count":1},{"id":"GO:0046711","count":1}]},{"hash":"86369377072864206","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000462","count":2}]},{"hash":"327126985589837052","title":"Mitochondrial protein import and mitophagy regulation","description":"GO terms show a strong emphasis on mitochondrial processes\u2014protein import into the mitochondrial matrix, calcium import into mitochondria, and regulation of mitophagy. While a few neural or transport terms appear, the core signal is mitochondrial function and quality control, justifying a label centered on mitochondria-related import and mitophagy. ","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":2},{"id":"GO:0045843","count":1},{"id":"GO:0006376","count":1},{"id":"GO:0006820","count":1},{"id":"GO:1903959","count":1}]},{"hash":"1510746848003504332","title":"Central Metabolism and Cofactor Biosynthesis","description":"This cluster's top GO terms highlight core metabolic and cofactor-related biosynthetic processes, including the TCA cycle, mitochondrial electron transport (succinate to ubiquinone), porphyrin/heme biosynthesis, thiamine biosynthesis, and quinolinate (NAD) biosynthesis, with some nucleotide catabolism. Together, they suggest a group of proteins involved in central metabolism and production of essential cofactors, rather than a single specialized pathway.","confidence":"Medium","size":7,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0006214","count":1},{"id":"GO:0055114","count":1}]},{"hash":"2255872376805902048","title":"RNAi and miRNA silencing machinery","description":"Genes/proteins in this cluster are tied to RNA interference and small RNA pathways: siRNA-mediated silencing, miRNA biogenesis (pre-miRNA processing), and ncRNA-regulated heterochromatin formation, plus co-transcriptional gene silencing by RNA interference machinery. Although a few terms are obsolete or broad (transcription/translation), the dominant theme is RNA silencing machinery and miRNA processing, supporting a cohesive functional module.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090625","count":3},{"id":"GO:0070924","count":3},{"id":"GO:0090502","count":3},{"id":"GO:0031054","count":3},{"id":"GO:0033562","count":3}]},{"hash":"1256516382778215979","title":"Unknown","description":"The top GO terms are a heterogeneous mix (reproduction, photosynthesis, plant development, replication-related processes, and even a bacterial pigment biosynthesis term) with no clear shared function. With no interactions (Edges 0, Triangles 0) and no cohesive biological theme, there isn't a concise label that accurately represents the cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007292","count":1},{"id":"GO:0015979","count":1},{"id":"GO:0006279","count":1},{"id":"GO:0090102","count":1},{"id":"GO:0010082","count":1}]},{"hash":"308187101631098577","title":"ECM remodeling and tissue morphogenesis","description":"The top GO terms point to extracellular matrix remodeling (bone resorption, basement membrane disassembly, collagen catabolic processes) and developmental morphogenesis (lung branching, decidualization, neural precursor proliferation). Despite a few outliers (e.g., chromatin-related term, hormone response), the shared theme is proteins involved in matrix remodeling linked to tissue development and morphogenesis. Confidence: Medium","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":2},{"id":"GO:0045453","count":2},{"id":"GO:0034769","count":2},{"id":"GO:0060448","count":2},{"id":"GO:0097067","count":2}]},{"hash":"107574294810867230","title":"Translation and Ubiquitin-Proteasome Regulation","description":"The cluster is marked by translation and ribosome-associated terms (translation, ribosomal large subunit assembly) alongside ubiquitin-proteasome\u2013related regulation (proteasomal degradation, ubiquitination regulation) and ufmylation, suggesting a shared theme of protein synthesis together with controlled protein turnover. Some terms related to osteoblast differentiation and glial proliferation appear, but the dominant signal ties to protein production and degradation pathways.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001649","count":2},{"id":"GO:0019731","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0000027","count":1},{"id":"GO:1990592","count":1}]},{"hash":"1781598562781360706","title":"Broad Developmental Regulators","description":"These proteins show enrichment for diverse developmental GO terms spanning heart morphogenesis, brain regions (telencephalon, midbrain, cerebellar cortex), pancreatic cell differentiation/maturation, and even acrosome assembly, plus a general transcription regulation term. The common thread appears to be regulatory roles in organogenesis across multiple tissues rather than a single pathway, suggesting a cluster of factors that modulate development broadly. ","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003007","count":1},{"id":"GO:0060287","count":1},{"id":"GO:0021696","count":1},{"id":"GO:0030901","count":1},{"id":"GO:0003310","count":1}]},{"hash":"500764474294563197","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0033129","count":4},{"id":"GO:0070935","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0044830","count":2}]},{"hash":"503151456807415531","title":"Neurite outgrowth and dendrite morphogenesis","description":"These proteins are linked to neuronal development and connectivity, with dendrite morphogenesis and fasciculation of sensory neuron axons as core themes. Receptor clustering and integrin signaling support adhesion-guided neurite outgrowth, while PDGF-related signaling and related growth cues fit the broader neural growth context. Some terms like angiogenesis are less specific but don\u2019t override the dominant neuronal development signal.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0097155","count":2},{"id":"GO:2000811","count":2},{"id":"GO:0048813","count":2}]},{"hash":"1747073853021365321","title":"DNA Damage Response","description":"The GO terms are dominated by nucleotide-excision repair, UV protection, and DNA-templated transcription, all central to sensing and repairing DNA damage and reprogramming transcription in response to damage. While additional terms touch on autophagy, immune signaling, and development, the strongest, recurring signal points to a DNA damage response and associated transcriptional regulation.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006289","count":2},{"id":"GO:0001113","count":1},{"id":"GO:0039530","count":1},{"id":"GO:0035315","count":1},{"id":"GO:0039520","count":1}]},{"hash":"458053358258070333","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":1},{"id":"GO:0035719","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0051259","count":1}]},{"hash":"1983771037098908123","title":"Transmembrane Transporters","description":"The top GO terms are heavily centered on transport across membranes, including sialic acid, fucose, nitrate, phosphate, sodium, arabinose, vitamin and xenobiotic transmembrane transport, plus a related role in neurotransmitter loading into synaptic vesicles. This points to a cluster of membrane transporter proteins with diverse substrates, rather than a single specific function. ","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":2},{"id":"GO:0006004","count":2},{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0006855","count":2}]},{"hash":"1327432691141497973","title":"Ubiquitin-Driven Proteostasis and Aggrephagy","description":"This cluster is enriched for ubiquitin-related processes (autoubiquitination, ubiquitin-dependent ERAD, protein sumoylation) and autophagic clearance (aggrephagy). The presence of terms related to cellular responses to toxic substances and DNA repair via ubiquitin signaling suggests a broader proteostasis network governed by ubiquitin pathways. The dominant theme is ubiquitin-mediated proteostasis and selective autophagy.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":6},{"id":"GO:0070911","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0035973","count":4},{"id":"GO:0097237","count":4}]},{"hash":"974460997166288996","title":"Rab-driven vesicle trafficking","description":"This cluster includes GO terms focused on vesicle trafficking and membrane dynamics: Rab protein signal transduction, vesicle docking involved in exocytosis, and regulation of vesicle size. Additional terms touch on nucleolar localization and membrane-associated processes like tight junction assembly, dendrite development, and signaling cascades, but the dominant signals point to vesicle trafficking and secretion pathways. Therefore a concise label capturing Rab-mediated vesicle trafficking best reflects the cluster\u2019s common function.","confidence":"High","size":6,"edges":6,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071701","count":6},{"id":"GO:0016358","count":6},{"id":"GO:0097494","count":6},{"id":"GO:1902570","count":6},{"id":"GO:1905289","count":6}]},{"hash":"667617704718280494","title":"Ribosome Biogenesis and mRNA Export","description":"The top GO terms cluster around ribosome biogenesis and assembly (cytosolic ribosome assembly; assembly of large subunit preribosome) and mRNA processing/export (mRNA export from nucleus), with an ancillary signal for transcription regulation. This suggests a module focused on preparing ribosomes for translation and coordinating gene expression, despite some background terms that may reflect broader RNA/protein maturation processes. ","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0017000","count":1},{"id":"GO:0006479","count":1}]},{"hash":"2148648385688436886","title":"Core Translation and Genome Maintenance","description":"The proteins appear to participate in fundamental cellular processes: translation (GO:0006412), ribosomal subunit assembly (GO:0000027), and protein complex oligomerization (GO:0035786) point to protein synthesis and assembly; cell cycle (GO:0007049) and DNA repair (GO:0006281) suggest genome maintenance; plasmid partitioning (GO:0030541) aligns with genetic inheritance. Energy provision via ATP synthesis (GO:0015986) supports these core processes. Some terms related to development or immune/hormone signaling (substantia nigra development, interleukin-4 response, dexamethasone stimulus) appear as outliers. Overall, the cluster centers on essential cellular machinery with only partial noise, hence a Moderate confidence.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0035786","count":1},{"id":"GO:0015986","count":1},{"id":"GO:0021762","count":1}]},{"hash":"1309426763935920741","title":"Unknown","description":"This set of GO terms covers protein folding, mitochondrial import, catalytic activity regulation, apoptosis, lipid transport, apoptotic cell recognition, and proprioception, with no single dominant function. The terms appear heterogeneous, suggesting either annotation noise or proteins with multiple unrelated roles; as such a cohesive functional cluster cannot be inferred.","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006457","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0050790","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0015917","count":1}]},{"hash":"2195758053314512996","title":"Unknown","description":"The terms are a\u6df7 mix of development (lung development, synapse assembly), drug responses (response to lithium, methotrexate), and several biosynthetic processes (lipid and polymer biosynthesis), with no single cohesive function linking all six proteins. A confident, specific label cannot be assigned.","confidence":"","size":6,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0010226","count":2},{"id":"GO:0051965","count":2},{"id":"GO:2001027","count":2}]},{"hash":"886056096507337149","title":"DNA replication and mitotic cell cycle control","description":"The top GO terms are dominated by DNA replication and mitotic cell-cycle transitions (G1/S and G2/M), suggesting these proteins mainly function in genome duplication and progression through cell division. Other terms present (hemopoiesis, antigen processing/presentation, various transport) are less representative of the core theme, so the name highlights the primary shared function.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0000082","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0030097","count":2},{"id":"GO:0046689","count":2}]},{"hash":"1429382700163316369","title":"Immune signaling and antigen processing","description":"The proteins are enriched for immune signaling (T cell receptor, TNF, C-type lectin receptor pathways) and antigen processing/presentation via MHC I with proteasome/ubiquitin turnover, pointing to a cohesive theme of immune activation and antigen processing, with some peripheral signals like zinc response and PCP.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0060071","count":3},{"id":"GO:0010043","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0002223","count":3}]},{"hash":"552015481547108091","title":"Mitochondrial energy metabolism","description":"The top GO terms are mitochondrial electron transport and proton-motive force\u2013driven ATP synthesis, pointing to oxidative phosphorylation as the core function of these proteins. A few development-related terms (Sertoli cell, eye development, embryo implantation) are present but likely ancillary or reflective of tissue-specific roles. Thus the cluster best represents mitochondrial energy production.","confidence":"Medium","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045740","count":2},{"id":"GO:0006122","count":2},{"id":"GO:0042776","count":2},{"id":"GO:0060009","count":1},{"id":"GO:0043129","count":1}]},{"hash":"2090778217997033379","title":"Cardiac muscle contraction and actin dynamics","description":"Top GO terms indicate cardiac muscle contraction and regulation, myofibril assembly, and multiple actin-related processes (actin remodeling, microspike assembly, vesicle transport along actin), along with calcium release regulation and cation channel activity. This combination points to a theme of cardiac muscle function intertwined with actin cytoskeleton remodeling and calcium signaling, despite the lack of protein\u2013protein connections in the cluster. High","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006936","count":1},{"id":"GO:0086004","count":1},{"id":"GO:0055003","count":1},{"id":"GO:0035191","count":1},{"id":"GO:0030050","count":1}]},{"hash":"2245597298520644469","title":"Lineage differentiation and developmental processes","description":"The top GO terms point to differentiation and development across multiple lineages (erythrocyte and megakaryocyte development, lymphoid progenitor differentiation, mesoderm development) and even tissue-specific differentiation (lung goblet cells, mammary gland epithelium). The mix suggests a theme of cell fate specification and developmental regulation rather than a single pathway, with miRNA transcription regulation possibly modulating these processes.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902895","count":1},{"id":"GO:0033600","count":1},{"id":"GO:0035855","count":1},{"id":"GO:0045610","count":1},{"id":"GO:0002320","count":1}]},{"hash":"1474441194115839173","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090262","count":1},{"id":"GO:0045638","count":1},{"id":"GO:0010390","count":1},{"id":"GO:0034402","count":1},{"id":"GO:0007480","count":1}]},{"hash":"1643945976004261401","title":"Aromatic amino acid catabolism and xenobiotic detox","description":"This cluster is dominated by GO terms for catabolic and detoxification pathways: L-tyrosine catabolic process, L-phenylalanine catabolic process, glutathione metabolic process, and xenobiotic catabolic process, along with related detoxification steps (e.g., methylglyoxal detox via lactoyl-glutathione). These suggest enzymes involved in breaking down aromatic amino acids and clearing xenobiotics. A single transcription regulation term appears incidental. Overall, a cohesive theme of aromatic amino acid breakdown and detox metabolism.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006572","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006749","count":1},{"id":"GO:0019243","count":1},{"id":"GO:0006559","count":1}]},{"hash":"1999688345177284611","title":"Cardiac contraction regulation and myofibril assembly","description":"The top GO terms are centered on cardiac muscle function: regulation of cardiac muscle contraction via calcium release, regulation of cardiac muscle cell contraction, and cardiac myofibril assembly. While some terms are unrelated (e.g., fungal sporulation, insect cuticle development), the strongest and most consistent signal relates to heart muscle contraction and structural assembly, suggesting this cluster reflects cardiac muscle function. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010881","count":2},{"id":"GO:0008365","count":2},{"id":"GO:0086004","count":2},{"id":"GO:0030437","count":2},{"id":"GO:0055003","count":2}]},{"hash":"2018234450341418041","title":"Chromatin regulation and genome organization","description":"The terms point to chromatin state and nucleus organization (heterochromatin formation, histone modification, chromatid cohesion) and to transcriptional regulation, suggesting a module focused on how chromatin architecture governs gene expression and chromosome maintenance. A couple of development/dosage-related terms relate to sex chromosome regulation but still align with nuclear regulatory processes.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007549","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0071674","count":2},{"id":"GO:0043457","count":2},{"id":"GO:0000183","count":2}]},{"hash":"906941544427224664","title":"Macrophage transcription and calcium signaling","description":"Top terms indicate transcriptional regulation (DNA-templated transcription, transcription regulation), chromatin-related regulation (nucleosome density, histone methylation), and immune-related processes (MHC class II biosynthesis, macrophage apoptotic regulation), along with calcium signaling (cellular response to calcium, SR calcium release). The combination suggests a cluster of proteins involved in transcriptional control in macrophages with calcium-dependent signaling, despite some obsolete annotations.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0036091","count":2},{"id":"GO:0060303","count":2},{"id":"GO:0045348","count":2},{"id":"GO:2000111","count":2}]},{"hash":"1680731130549139152","title":"Chaperone-Mediated Stress Response and Inflammation","description":"The top GO terms cluster around protein folding/refolding (chaperone-dependent and general protein refolding), negative regulation of ROS biosynthesis (oxidative stress management), and inflammatory signaling (TNF production and inflammatory response), plus ischemia response. This suggests a group of proteins involved in managing cellular stress through chaperone activity and associated inflammatory pathways. Some terms about telomere localization or host-cell translocation appear less central and may be noise within this cluster. Overall, the theme is coherent: stress response with chaperone-driven protein quality control and inflammatory signaling.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1903427","count":3},{"id":"GO:0051085","count":3},{"id":"GO:1904874","count":3},{"id":"GO:0033198","count":3},{"id":"GO:1904469","count":3}]},{"hash":"2050978075569422746","title":"Unknown","description":"The terms span many unrelated biological areas (eye vasculature development, liver differentiation, aldosterone-regulated blood volume, metal and xenobiotic responses, ozone response, uterus development, steroid biosynthesis, and reproductive processes), with no clear shared function or pathway connecting the proteins. Given zero edges and diverse annotations, there isn\u2019t a coherent theme to label beyond Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":1},{"id":"GO:0070365","count":1},{"id":"GO:0002017","count":1},{"id":"GO:0071280","count":1},{"id":"GO:0042738","count":1}]},{"hash":"2026767006097182491","title":"Gluconeogenesis and glycolysis regulation","description":"This cluster shows GO terms centered on carbohydrate metabolism, especially gluconeogenesis and glycolytic regulation (including fructose-6-phosphate metabolism and glycerol catabolic processes). Additional terms touch on inositol biosynthesis and detox-related responses, but the strongest common theme among the terms is regulation of glucose-derived metabolism rather than a single pathway or function. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051289","count":1},{"id":"GO:0030308","count":1},{"id":"GO:0019563","count":1},{"id":"GO:0045820","count":1},{"id":"GO:0006021","count":1}]},{"hash":"1351346742597443390","title":"Immune response and antibody production","description":"This cluster is dominated by immune-related GO terms, notably immunoglobulin production and positive regulation of defense responses to viruses, with B cell apoptotic processes supporting a humoral/immune context. While some terms appear obsolete or unrelated (e.g., cerebellar cortex development, certain RNA processing terms), the overall pattern points to antibody-mediated immune functions and antiviral defense as the core theme. Therefore, the label reflects the most representative function of the cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0090202","count":1},{"id":"GO:0021695","count":1},{"id":"GO:0001783","count":1},{"id":"GO:0000448","count":1}]},{"hash":"29809024935350669","title":"Developmental morphogenesis and differentiation regulation","description":"These five proteins are tied to multiple developmental and morphogenesis-related GO terms, including embryonic body morphogenesis, myoblast differentiation, synapse assembly, and ovulation cycle. While there are additional terms related to transcription regulation, Rho signaling, cytoskeletal localization, and tissue boundary specification, the strongest common thread appears to be regulation of developmental processes and tissue differentiation rather than a single biochemical function. Therefore this label reflects an overarching developmental differentiation theme for the cluster.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043065","count":3},{"id":"GO:0072699","count":3},{"id":"GO:0045945","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0042698","count":3}]},{"hash":"2070374334296049522","title":"Neuronal Sensory Perception and Dopaminergic Signaling","description":"The GO terms cluster around neural sensory functions (visual perception and pain perception) and dopaminergic synaptic transmission, with ERK cascade regulation and protein phosphorylation as shared signaling mechanisms. Some terms point to broader processes (heart development, macrophage chemotaxis), but the dominant theme is neuronal signal processing and dopamine-related signaling.","confidence":"Medium","size":5,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":4},{"id":"GO:0008542","count":3},{"id":"GO:0048148","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0071380","count":3}]},{"hash":"2101980480707705327","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning cilium assembly, immune regulation, nuclear localization, vascular and neural development, plant stamen development, intracellular signaling, and even an obsolete oxidation-reduction term. With no single coherent function connecting these terms and each term appearing only once, there is no clear theme to label this cluster; thus Unknown with None confidence.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902857","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0002820","count":1},{"id":"GO:1900181","count":1},{"id":"GO:0036303","count":1}]},{"hash":"129824631952232618","title":"Unknown","description":"The GO terms include deubiquitination, vesicle transport, plant hormone biosynthesis, cholangiocyte proliferation, ion-channel regulation, and cyclic nucleotide synthesis, with little overlap pointing to a single pathway. This cluster does not show a clear common function, so a specific label cannot be assigned.","confidence":"","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":2},{"id":"GO:0072383","count":1},{"id":"GO:0009688","count":1},{"id":"GO:1990705","count":1},{"id":"GO:1905150","count":1}]},{"hash":"1202915019445906278","title":"Membrane trafficking and cytoskeleton dynamics","description":"Label reflects dominant GO terms related to intracellular transport, Golgi retention, vesicle recycling, and membrane-cytoskeleton interactions (e.g., vesicle trafficking, receptor internalization, actin patches). While there are also terms tied to growth and stress responses, the strongest signals pertain to membrane trafficking and cytoskeletal remodeling.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0051301","count":2},{"id":"GO:1903423","count":1},{"id":"GO:0034340","count":1}]},{"hash":"173330111152191011","title":"Mitochondrial membrane organization and adhesion signaling","description":"The cluster\u2019s terms point to membrane-associated processes: inner mitochondrial membrane organization and cardiolipin metabolism (mitochondrial membranes), localization to membrane rafts, and cadherin-mediated cell adhesion and cell\u2013cell adhesion signaling. Podocyte development also implicates specialized membrane/cytoskeletal organization. Dopaminergic synaptic transmission hints at neural signaling tied to membrane compartments. Taken together, these proteins appear connected through membrane structure and signaling rather than a single linear pathway, justifying a membrane-centric name with a moderate level of confidence.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0072249","count":1},{"id":"GO:0045861","count":1},{"id":"GO:0045541","count":1},{"id":"GO:1900210","count":1},{"id":"GO:0060355","count":1}]},{"hash":"230907123153533337","title":"Rac-driven actin remodeling and cell adhesion","description":"The top GO terms cluster around Rac protein signaling and actin cytoskeleton dynamics, including positive regulation of stress fiber and filopodium assembly, substrate adhesion-dependent cell spreading, and Rac-mediated signal transduction. This strongly suggests a function group centered on Rac-regulated actin remodeling and adhesion structures, with some related terms like dendrite development and spindle assembly likely reflecting broader cytoskeletal roles. ","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0051496","count":2},{"id":"GO:0016601","count":2}]},{"hash":"2148779201208483583","title":"G Protein-Coupled Receptor Signaling","description":"Top GO terms are centered on GPCR signaling (tachykinin receptor signaling, G protein-coupled acetylcholine receptor signaling) with connected intracellular signal transduction and cardiac muscle regulation (contraction/relaxation, hypertrophy). A few terms are less connected (zygotic division, symbiont-induced NF-kappaB activation), but the dominant pattern points to GPCR-mediated signaling, occasionally tied to cardiac function. Therefore, the cluster is best described as GPCR signaling with cardiac regulation components.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010070","count":1},{"id":"GO:0007217","count":1},{"id":"GO:0085033","count":1},{"id":"GO:0043407","count":1},{"id":"GO:0035556","count":1}]},{"hash":"1671767994761276958","title":"Mitochondrial Transport Proteins","description":"The top GO terms are dominated by various transmembrane transport activities, especially across mitochondria (e.g., ADP transport, mitochondrial citrate transmembrane transport, magnesium export from mitochondrion, thiosulfate and CoA transport). A couple of terms refer to ER targeting or unrelated processes, but the strongest signal is mitochondrial membrane transport. This cluster likely groups proteins functioning as mitochondrial transporters.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006465","count":1},{"id":"GO:0045047","count":1},{"id":"GO:0006843","count":1},{"id":"GO:0030974","count":1},{"id":"GO:0035435","count":1}]},{"hash":"174516118751342108","title":"Unknown","description":"The GO terms are scattered across nuclear transport and cell division (e.g., intracellular transport, mitotic nuclear membrane reassembly, synaptonemal complex assembly) plus unrelated processes (vascular development, receptor internalization, ciliogenesis, desumoylation regulation). With only five proteins and no edges, there is no cohesive theme to define a reliable, representative label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":1},{"id":"GO:0010032","count":1},{"id":"GO:0060976","count":1},{"id":"GO:0007084","count":1},{"id":"GO:0060188","count":1}]},{"hash":"795783068598673628","title":"Forebrain and neural development","description":"Most of the top GO terms point to neural development and brain patterning, including cerebral cortex regionalization, forebrain development and patterning, neuronal fate commitment in the forebrain, and retina development. While a couple terms (thyroid gland development, ureteric bud morphogenesis) are from non-neural organ systems, the dominant signal is neural specification and regionalization, suggesting the cluster comprises proteins involved in neural development and brain patterning.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021796","count":2},{"id":"GO:0003309","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0021902","count":2},{"id":"GO:0030878","count":2}]},{"hash":"609015488267906781","title":"RNA export and trafficking","description":"The top GO terms point to RNA processing and export from the nucleus (mRNA export, nonfunctional rRNA decay, stress granule disassembly), with additional hints of intracellular trafficking and organelle targeting (peroxisome matrix import, Golgi retention, vesicle formation). This mix suggests a cluster whose members participate in RNA metabolism and some aspects of protein targeting/trafficking, rather than a single, cohesive pathway. Confidence: Low.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0051260","count":2},{"id":"GO:0030420","count":2},{"id":"GO:0016558","count":2},{"id":"GO:0046034","count":2}]},{"hash":"1721366308564032902","title":"Unknown","description":"The set spans disparate processes\u2014from protein modification and muscle regulation to ear development, cuticle formation, and sporulation\u2014without a single unifying function, so there is no coherent label beyond Unknown.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0033234","count":4},{"id":"GO:0014718","count":4},{"id":"GO:0030916","count":4},{"id":"GO:0043388","count":4},{"id":"GO:0010881","count":3}]},{"hash":"287149132569983161","title":"Ubiquitin-Dependent Proteolysis and Cell Cycle Regulation","description":"This cluster is enriched for ubiquitin-mediated degradation pathways (ERAD, SCF, autoubiquitination, K11-linked), proteasomal protein catabolic processes, and cell cycle transitions (G2/M, mitotic cell cycle), with additional proteostasis-related terms like aggrephagy and embryonic development. The common thread is regulation of protein turnover by ubiquitination, linking proteostasis to mitosis and development.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0070911","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0000086","count":2},{"id":"GO:0031146","count":2}]},{"hash":"290424043994484396","title":"Muscle sarcomere and actin filament assembly","description":"This cluster's top GO terms are dominated by actin patch assembly, sarcomere organization, and skeletal muscle development and thin filament assembly, pointing to proteins involved in muscle fiber structure and cytoskeleton. Some terms are obsolete, but the core theme remains muscle-related; a few non-muscle terms may reflect broader or noise annotations.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":3},{"id":"GO:0043486","count":3},{"id":"GO:0043982","count":3},{"id":"GO:0016344","count":3},{"id":"GO:0048741","count":3}]},{"hash":"72451464132210184","title":"Unknown","description":"The top GO terms cover mitosis, nuclear export, morphogenesis, immune signaling, ER polarization, and radiation response, with no single unified function linking the four proteins. Because of this heterogeneity and lack of a clear shared process, there is no coherent theme to define a specific, representative function for the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007100","count":3},{"id":"GO:0046827","count":3},{"id":"GO:0060444","count":2},{"id":"GO:0042698","count":2},{"id":"GO:0061762","count":2}]},{"hash":"307870988226242033","title":"Cytoskeletal dynamics and trafficking","description":"The cluster\u2019s top GO terms cluster around cytoskeleton and trafficking: microtubule-based movement, mitotic spindle assembly, and Arp2/3-mediated actin nucleation point to cytoskeletal remodeling, while GPCR internalization suggests vesicle trafficking that often relies on cytoskeletal machinery. The presence of GTPase activity regulation further supports a theme of cytoskeletal control and membrane dynamics, despite some tissue-specific terms. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0002031","count":2},{"id":"GO:0051260","count":1}]},{"hash":"1612723400957931892","title":"RNA-sensing antiviral innate immunity","description":"This cluster is driven by GO terms for detecting viruses and mounting innate antiviral responses, including positive regulation of RIG-I signaling and negative regulation of MDA-5 signaling, pointing to RNA virus sensing and defense pathways; a couple of RNA-processing terms are present but the dominant theme is antiviral innate immunity.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071042","count":1},{"id":"GO:0009597","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0002230","count":1},{"id":"GO:0039534","count":1}]},{"hash":"1628028825247001691","title":"Unknown","description":"The top GO terms span diverse processes\u2014from protein interactions and ubiquitin-related regulation to photosystem II repair, autophagy, SNARE/microtubule dynamics, and development\u2014without a single cohesive function linking them. This makes a specific, representative label difficult to justify, so Unknown is appropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":1},{"id":"GO:1903007","count":1},{"id":"GO:1903862","count":1},{"id":"GO:0010206","count":1},{"id":"GO:1990171","count":1}]},{"hash":"1298826739090247625","title":"DNA replication and cell cycle","description":"Dominant GO terms are DNA replication (GO:0006260) and mitotic centrosome separation (GO:0007100), which together suggest a core role in DNA synthesis and chromosome segregation. Other terms\u2014branching involved in mammary gland duct morphogenesis, ovulation cycle, CAMKK-AMPK signaling cascade, endoplasmic reticulum polarization, cellular response to ionizing radiation, and regulation of telomerase activity\u2014likely reflect broader or pleiotropic roles of the proteins or annotation noise. Overall, the cluster seems best described by a DNA replication and cell cycle theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0000902","count":4},{"id":"GO:0060444","count":3},{"id":"GO:0042698","count":3},{"id":"GO:0061762","count":3}]},{"hash":"1554516702157933825","title":"Placental and embryonic development","description":"GO terms indicate placental formation (trophoblast giant cell differentiation; placental development) and broader embryonic morphogenesis (left/right pattern formation; EMT in endocardial cushion formation; cartilage morphogenesis; endocrine system development). This points to a developmental module centered on placental and embryonic formation rather than a specific molecular function, hence the label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0060536","count":1}]},{"hash":"237596872546812960","title":"Neuronal vesicle trafficking and localization","description":"This cluster centers on vesicle transport, Rab signaling, and protein localization processes, including nucleolar localization and regulation of secretory pathways, with supportive hints from dendrite development and cell polarity terms. Taken together, the proteins likely function in intracellular transport and localization in neurons, coordinating vesicle trafficking, polarity, and related signaling pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000060","count":3},{"id":"GO:0016358","count":3},{"id":"GO:0097494","count":3},{"id":"GO:0034629","count":3},{"id":"GO:0071701","count":3}]},{"hash":"1827964795725421029","title":"Potassium Transport and Membrane Potential Regulation","description":"This cluster's top GO terms cluster around membrane potential maintenance and potassium ion transport (e.g., membrane repolarization, intracellular potassium homeostasis, regulation/stabilization of resting membrane potential). These point to proteins involved in ionic balance and cellular excitability, rather than sensory or thermogenic processes, making \"Potassium Transport and Membrane Potential Regulation\" the most representative label.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098914","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0050976","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0071502","count":2}]},{"hash":"1364919727540850168","title":"Unknown","description":"The top terms include RNA modification, tRNA processing, methylation, and tetrahydrofolate metabolism, suggesting a possible link to one-carbon and RNA-related processes. However, several terms (protein localization to plasma membrane, phosphatidylinositol phosphate biosynthesis, myelination) point to distinct, membrane- and tissue-level roles, and there is little evidence of a single coherent function tying all four proteins together. Without a clear unifying pathway, the cluster is best labeled Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009451","count":1},{"id":"GO:0006579","count":1},{"id":"GO:0090002","count":1},{"id":"GO:0042426","count":1},{"id":"GO:1901053","count":1}]},{"hash":"63846900699363554","title":"Membrane Transport and DNA Processing","description":"The top GO terms show two strong transmembrane transport functions (vitamin and xenobiotic), suggesting a membrane transport theme. Other annotations point to DNA-centric processes (nucleotide-excision repair, DNA replication) and organelle protein trafficking (peroxisomal import), indicating a mix of transport and DNA-processing roles. Because there is no single cohesive function tying all terms together, label it as broadly membrane- and DNA-processing related with moderate confidence.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0051260","count":1}]},{"hash":"870634076030937266","title":"Unknown","description":"The top GO terms span nuclear processes like DNA replication and mRNA export, but also include autophagosome maturation, microtubule depolymerization, oxidative phosphorylation, and other unrelated processes. There is no single cohesive function linking these terms, so the cluster cannot be confidently named beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0045071","count":2},{"id":"GO:0051260","count":1},{"id":"GO:1903007","count":1}]},{"hash":"1236243294461616322","title":"Unknown","description":"The GO terms are dominated by DNA replication/biosynthetic processes but also include a mix of autophagy, vesicle trafficking, cytoskeletal dynamics, and stress-response related terms, giving no single cohesive function for the cluster. This makes it impossible to assign a specific, representative label with confidence.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071897","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0051260","count":1},{"id":"GO:1903007","count":1},{"id":"GO:1903862","count":1}]},{"hash":"1666318505781834237","title":"Unknown","description":"The top GO terms span diverse processes (exocytosis, differentiation in kidney and nervous system, growth hormone and immune signaling) with no clear shared function or pathway. Without a cohesive theme, the cluster does not map to a single recognizable biological role.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000768","count":1},{"id":"GO:0071657","count":1},{"id":"GO:0006887","count":1},{"id":"GO:0070886","count":1},{"id":"GO:0090334","count":1}]},{"hash":"570895772665608097","title":"Immune and vascular signaling regulation","description":"The GO terms cluster around immune and inflammatory control (negative regulation of neutrophil degranulation, negative regulation of respiratory burst, positive regulation of TNF production) and vascular functions (regulation of vascular permeability, negative regulation of blood vessel remodeling), plus key signaling pathways such as phosphatidylinositol dephosphorylation and the calcineurin-NFAT cascade. This points to a set of proteins that modulate inflammatory and vascular signaling rather than structural roles. A few items (e.g., imaginal disc-derived leg morphogenesis) are less directly connected, likely reflecting broader developmental regulatory themes in the dataset.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":1},{"id":"GO:0046856","count":1},{"id":"GO:0090334","count":1},{"id":"GO:0060313","count":1},{"id":"GO:0032760","count":1}]},{"hash":"706890362426607334","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001682","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0000492","count":1},{"id":"GO:0048025","count":1},{"id":"GO:0031118","count":1}]},{"hash":"1307956189495085618","title":"Developmental Morphogenesis Signaling","description":"The GO terms cluster around retinoic acid response, branching morphogenesis in mammary glands, ovulation, and chondrocyte growth, pointing to developmental patterning and tissue morphogenesis. Other terms like CAMKK-AMPK signaling, centrosome separation, ER polarization, and stress/immune responses appear as contextual or supporting processes that can accompany development. Overall, the proteins likely participate in developmental signaling and morphogenesis rather than a single narrow pathway.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071300","count":2},{"id":"GO:0060444","count":1},{"id":"GO:0042698","count":1},{"id":"GO:0061762","count":1},{"id":"GO:0007100","count":1}]},{"hash":"1398456077660555698","title":"Neural myelination and skeletal muscle growth signaling","description":"This cluster centers on neural development and myelination (neuron development, negative regulation of myelination, myelin assembly) and on skeletal muscle growth and maintenance (positive regulation of skeletal muscle tissue growth, muscle cell cellular homeostasis). The presence of signaling-related terms like transforming growth factor beta receptor signaling and phosphatidylinositol metabolism suggests a shared regulatory theme that could coordinate neural and muscle development. Because each term has low frequency (mostly singletons) and there are no edges, the linkage is plausible but not strongly supported, justifying a cautious, low confidence label.","confidence":"Low","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031642","count":1},{"id":"GO:0035335","count":1},{"id":"GO:0032288","count":1},{"id":"GO:0046856","count":1},{"id":"GO:0048666","count":1}]},{"hash":"1684614508905146423","title":"Flavonoid Biosynthesis","description":"This cluster is driven by GO terms for flavonoid and anthocyanin-related biosynthesis, including cyanidin and quercetin glycoside biosynthesis, indicating a shared function in plant secondary metabolite production. While a few terms reference unrelated biosynthetic processes, the strongest signals are flavonoid-related, justifying a flavonoid biosynthesis label.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0009718","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0070980","count":1}]},{"hash":"1094288698549129129","title":"Developmental Morphogenesis Regulators","description":"The top GO terms cluster around various aspects of development and morphogenesis (bud/tracheal outgrowth, axon development, rhombomere formation) and include regulatory signaling processes (PI3K/AKT, ERK cascade, GTPase activity, phosphatase activity, protein deacetylation), suggesting these proteins collectively influence developmental patterning and tissue morphogenesis rather than a single specific function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060449","count":1},{"id":"GO:0061564","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0007426","count":1},{"id":"GO:0051897","count":1}]},{"hash":"766808884814534256","title":"Glutathione-Mediated Xenobiotic Detox","description":"The GO terms are dominated by glutathione metabolism and related detoxification processes (glutathione metabolic process, glutathione derivative biosynthetic process, xenobiotic catabolic process, nitrobenzene metabolic process), suggesting a common theme of detoxification and redox-related metabolism of xenobiotics. While a few terms touch on regulatory or metal response, the core signal points to glutathione-driven processing of foreign compounds. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010043","count":1},{"id":"GO:0006749","count":1},{"id":"GO:0035732","count":1},{"id":"GO:2000469","count":1},{"id":"GO:0018916","count":1}]},{"hash":"244502581692001013","title":"Redox Homeostasis and Oxidative Stress Response","description":"This cluster's GO terms are dominated by redox-related processes: cell redox homeostasis, cellular oxidant detoxification, protein deglutathionylation, and cellular response to oxidative stress. While a few terms are less related, the prominent redox signals support a cohesive role in managing cellular redox balance and oxidative stress.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":1},{"id":"GO:0034599","count":1},{"id":"GO:0080058","count":1},{"id":"GO:0071473","count":1},{"id":"GO:0055114","count":1}]},{"hash":"507064031761513965","title":"Unknown","description":"The top GO terms span RNA processing and transcription regulation (splicing, RNA Pol II control) but also include heart development, brassinosteroid signaling, and nitric oxide biosynthesis, showing no single cohesive pathway. With no connecting edges and a scattered term set, a clear, specific functional label isn\u2019t supported. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901798","count":1},{"id":"GO:0045736","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0007507","count":1},{"id":"GO:0000350","count":1}]},{"hash":"880386482892704285","title":"Transmembrane nutrient transporters","description":"The GO terms show several transmembrane transport activities for vitamins, sugars, and ions (pantothenate, biotin, glucose, myo-inositol, sodium ions), suggesting the proteins function primarily as membrane transporters for nutrients and ions. The acetylcholine biosynthetic process is tangential to transport, but does not negate the central theme of transporters.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015887","count":1},{"id":"GO:0015878","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0008292","count":1}]},{"hash":"2019109341775232208","title":"Cytochrome c Heme Linkage","description":"The cluster is defined by a single GO term: cytochrome c-heme linkage, indicating proteins involved in covalent attachment of the heme group to cytochrome c, a specific feature of c-type cytochromes. With a small set of proteins and this precise function, the cluster likely centers on this heme-c linkage activity.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018063","count":1}]},{"hash":"1454495226746448511","title":"RNAi-Mediated Gene Silencing and Small RNA Processing","description":"This cluster shows multiple GO terms tied to RNA silencing and small RNA pathways\u2014siRNA-mediated mRNA destabilization, piRNA processing, and pre-miRNA processing\u2014and to co-transcriptional gene silencing by RNAi machinery, with supporting terms about heterochromatin formation. Together these point to a shared function in RNA interference and small RNA biogenesis, hence the proposed label. Some terms relate to development, but the RNAi theme dominates.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0090625","count":1},{"id":"GO:0070924","count":1},{"id":"GO:0010050","count":1},{"id":"GO:0030718","count":1}]},{"hash":"15553037889919721","title":"Membrane Proteolysis and NFAT Signaling Modulation","description":"Top GO terms suggest membrane protein proteolysis (ectodomain and intracellular domain) and retrograde transport, paired with regulation of immune response and positive regulation of the calcineurin-NFAT signaling cascade. This points to a cohesive theme where proteolytic processing of membrane proteins influences NFAT-related signaling and immune regulatory processes, though the exact proteins and pathways are diverse. Confidence in this label is intermediate because while there is a clear proteolysis and NFAT signal, other terms (fibrinolysis, tubule cavitation) add complexity.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070886","count":1},{"id":"GO:1904211","count":1},{"id":"GO:0050776","count":1},{"id":"GO:0031293","count":1},{"id":"GO:0051533","count":1}]},{"hash":"1750660257874291343","title":"Membrane sugar and metabolite transporters","description":"The top GO terms are centered on transport across membranes for sugars and metabolites (sialic acid, fructose, glucose, trehalose, phosphate ions, 4-hydroxyphenylacetate) and also include a vesicular neurotransmitter loading function, suggesting a small cluster of transporter proteins specialized in importing and shuttling small solutes. This supports a concise label focusing on membrane transport of sugars and related metabolites.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":2},{"id":"GO:0052106","count":2},{"id":"GO:1900754","count":2},{"id":"GO:1990539","count":2},{"id":"GO:0044381","count":2}]},{"hash":"1290207775266387396","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039702","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0010587","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0019068","count":1}]},{"hash":"1449881234174968606","title":"Microtubule Cytoskeleton and Spindle Assembly","description":"Top GO terms indicate strong enrichment for mitotic spindle assembly, centrosome separation, spindle orientation, chromosome alignment, and microtubule polarity and transport, pointing to microtubule-based mitotic/spindle functions. A few terms (neuron projection maintenance, chloroplast movement) are peripheral but can be related to broader cytoskeletal roles. Overall, the pattern consistently reflects microtubule dynamics driving spindle and cytoskeletal organization.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0060404","count":1},{"id":"GO:0009904","count":1},{"id":"GO:0010938","count":1},{"id":"GO:1990535","count":1}]},{"hash":"68210968342955876","title":"mRNA splicing and processing","description":"This cluster\u2019s top GO terms are centered on mRNA splicing via the spliceosome and related post-transcriptional regulation (e.g., regulation of splicing, mRNA binding, mitochondrial mRNA polyadenylation), pointing to a shared RNA processing function. A few peripheral terms (neuronal action potential, host-virus RNA interactions, lipid biosynthesis regulation) are present but do not define the core theme. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0044830","count":1},{"id":"GO:0010323","count":1},{"id":"GO:0097222","count":1},{"id":"GO:0098908","count":1}]},{"hash":"819497285556213115","title":"Mitotic spindle assembly and Golgi-ER trafficking","description":"The top GO terms center on mitotic spindle assembly, mitotic cell cycle, and cell division, indicating proteins involved in chromosome segregation during mitosis. There are also vesicle trafficking terms (COPII-coated vesicle budding and retrograde Golgi-ER transport), suggesting a link between mitotic processes and secretory pathway dynamics. Some development-related terms appear, but the core signal points to mitosis and associated trafficking.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0090114","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0097498","count":3}]},{"hash":"40069183842332887","title":"Embryonic Organogenesis and Tissue Differentiation","description":"The GO terms point to broad developmental processes across multiple tissues, including embryonic morphogenesis, endodermal differentiation, gland development (salivary, prostate), myoblast differentiation, and synapse formation, suggesting a cohesive theme of organogenesis and tissue specification rather than a single pathway.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042698","count":3},{"id":"GO:0007432","count":3},{"id":"GO:1902997","count":3},{"id":"GO:0010172","count":3},{"id":"GO:0045663","count":3}]},{"hash":"961842073203683458","title":"Developmental tissue morphogenesis and differentiation","description":"The GO terms point to broad developmental processes across tissues: embryonic morphogenesis, endodermal differentiation, mesenchymal-epithelial signaling in gland development, myoblast differentiation, vestibular receptor morphogenesis, and synapse assembly. These collectively suggest a theme of development and tissue organization rather than a single mature cellular pathway, making a label focused on morphogenesis and differentiation appropriate.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042698","count":2},{"id":"GO:0007432","count":2},{"id":"GO:1902997","count":2},{"id":"GO:0010172","count":2},{"id":"GO:0045663","count":2}]},{"hash":"436115524877805665","title":"Neural tube and spinal cord development","description":"The cluster is dominated by GO terms for nervous system and embryonic development, notably spinal cord development, neural tube closure, forebrain development, and broader multicellular organism development, with skeletal system development also appearing. A few terms refer to stress responses or the mitotic cell cycle, but the core signal is neural tube/brain morphogenesis during embryogenesis.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0001403","count":2}]},{"hash":"31919125088007890","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001746","count":1},{"id":"GO:0042733","count":1},{"id":"GO:2000358","count":1},{"id":"GO:0045445","count":1},{"id":"GO:0060447","count":1}]},{"hash":"1674461929924377162","title":"Unknown","description":"The GO terms span wildly diverse biology (fungal lipid metabolism, myelin maintenance, sebaceous gland differentiation, plant flower development, etc.) and there are no connecting edges or a shared function among the proteins. With no coherent theme linking the terms, the safest, most neutral label is Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006675","count":1},{"id":"GO:0032286","count":1},{"id":"GO:0001949","count":1},{"id":"GO:0006809","count":1},{"id":"GO:0006636","count":1}]},{"hash":"954328796089883706","title":"Rho GTPase signaling and cytoskeleton dynamics","description":"The top GO terms emphasize small GTPase\u2013mediated signaling, especially Rho pathways, linked to actin cytoskeleton polarity, cell migration, wound healing, and endothelial tube formation, suggesting a cohesive module where Rho GTPases drive cytoskeletal remodeling to enable movement and angiogenesis.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0090334","count":2},{"id":"GO:0051683","count":2},{"id":"GO:0090051","count":2},{"id":"GO:0098887","count":2}]},{"hash":"766979540076917066","title":"RNA silencing and small RNA processing","description":"The top GO terms cluster around RNA-based regulatory processes: piRNA processing, pre-miRNA processing, and siRNA-mediated gene silencing by mRNA destabilization, plus regulatory ncRNA-mediated heterochromatin formation. These point to a shared theme of small RNA pathways and ncRNA-driven gene regulation. A few terms (apoptotic processes, germline maintenance, vegetative phase change) are less directly related, but may reflect co-regulation in certain organisms or annotation noise. Overall, the dominant signal is RNA silencing and ncRNA processing.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":1},{"id":"GO:0015917","count":1},{"id":"GO:0043654","count":1},{"id":"GO:0090625","count":1},{"id":"GO:0070924","count":1}]},{"hash":"1347858186838023570","title":"Dendritic Vesicle Trafficking and Signaling","description":"The top GO terms emphasize vesicle trafficking and Rab-mediated transport (Rab signaling, vesicle docking) and neuronal context (dendrite development), with supplementary signaling pathways (CAMKK-AMPK). While a few terms are broader or unrelated, the strongest shared theme across the cluster is vesicle transport in a dendritic/neuron-like setting, justifying a label focused on neuronal vesicle trafficking and signaling.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071701","count":1},{"id":"GO:0016358","count":1},{"id":"GO:0097494","count":1},{"id":"GO:1902570","count":1},{"id":"GO:1905289","count":1}]},{"hash":"1248178179246867439","title":"Vertebrate neural and sensory organ development","description":"This cluster is dominated by neural development terms (motor neuron fate specification, visceral motor neuron differentiation, ventral spinal cord interneuron specification, motor neuron axon guidance) and includes sensory organ formation (cochlea morphogenesis). Additional terms cover broader organogenesis (nephric duct elongation, uterine epithelium development, female gonad development) and signaling regulation, suggesting a overarching theme of vertebrate tissue development with a strong neural/sensory emphasis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021520","count":2},{"id":"GO:0021524","count":2},{"id":"GO:0035849","count":2},{"id":"GO:0035852","count":2},{"id":"GO:0035847","count":2}]},{"hash":"1127341323084855649","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000294","count":1},{"id":"GO:0001682","count":1},{"id":"GO:0006364","count":1},{"id":"GO:1905267","count":1},{"id":"GO:0034965","count":1}]},{"hash":"1998724695000117414","title":"RNA Pol II Transcription Regulation & Elongation","description":"The terms cluster around RNA polymerase II\u2013driven transcription, including preinitiation complex assembly and elongation, with connections to chromatin regulation; a minority term references tRNA transcription by Pol III, but the dominant theme is transcription control by RNA Pol II.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010793","count":1},{"id":"GO:0070827","count":1},{"id":"GO:0090239","count":1},{"id":"GO:0045899","count":1},{"id":"GO:0051123","count":1}]},{"hash":"158616386138683627","title":"Vesicle trafficking and dopamine secretion","description":"The set is anchored by intracellular protein transport and vesicle fusion, with a notable term on dopamine secretion, indicating roles in vesicle-mediated neurotransmitter release. Although there are immune- and cell-cycle\u2013related terms, they are less prominent, so the primary theme remains vesicle trafficking and secretion.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":1},{"id":"GO:0031340","count":1},{"id":"GO:0050859","count":1},{"id":"GO:0043619","count":1},{"id":"GO:0016540","count":1}]},{"hash":"1868291975246199857","title":"Unknown","description":"The GO terms across the cluster are scattered across immune (T cell cytotoxicity, macrophage apoptosis), inflammatory (bradykinin catabolic process, response to toxic substance), and housekeeping processes (autophagy of mitochondrion, proteasome core complex import), plus lung-related surfactant homeostasis and a couple of obsolete terms. There isn\u2019t a single coherent function or pathway that ties these proteins together, and the diversity makes a confident, specific label inappropriate.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043129","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0035593","count":1},{"id":"GO:0010815","count":1},{"id":"GO:1903146","count":1}]},{"hash":"1475897909544109701","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003334","count":1},{"id":"GO:0016479","count":1},{"id":"GO:0061158","count":1},{"id":"GO:0010586","count":1},{"id":"GO:0030036","count":1}]}]