{"hash":"1380044996428353656","title":"Ribosome biogenesis and translation machinery","description":"The cluster is strongly enriched for translation (GO:0006412) and ribosome biogenesis terms (GO:0042254, GO:0042273), indicating involvement in ribosome assembly and protein synthesis. Additional signals for transcription regulation and DNA damage response (p53 pathway, gamma radiation, UV) suggest coordination of gene expression and stress responses under DNA damage, but the core theme centers on ribosome production and translation. Confidence: High","confidence":"","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"ribosome biogenesis","members":[{"accession":"XP_012895182.1","go_terms":["GO:0002181","GO:0046677"]},{"accession":"XP_012895948.1","go_terms":["GO:0042254","GO:0006412"]},{"accession":"XP_012899200.1","go_terms":["GO:0042254","GO:0000028","GO:0006412","GO:0006407"]},{"accession":"XP_012893677.1","go_terms":["GO:1901194","GO:0006412"]},{"accession":"XP_012894242.1","go_terms":["GO:1902164","GO:1902167","GO:0032784","GO:0006977","GO:1904803","GO:0042273","GO:0031564","GO:0071480","GO:0006354","GO:0006353","GO:0045727","GO:0006412"]},{"accession":"XP_012894254.1","go_terms":["GO:0002181","GO:1990090","GO:0032543"]},{"accession":"XP_012895749.1","go_terms":["GO:0071353","GO:0006412","GO:0000027"]},{"accession":"XP_012898915.1","go_terms":["GO:0006412"]},{"accession":"XP_012894020.1","go_terms":["GO:0000462","GO:0006412"]},{"accession":"XP_012893733.1","go_terms":["GO:0006412"]},{"accession":"XP_012893888.1","go_terms":["GO:0022605","GO:0006924","GO:0000082","GO:0042274","GO:0007369","GO:0042254","GO:0043065","GO:0048821","GO:0002309","GO:0033077","GO:0031929","GO:0000462","GO:0031167","GO:0001890","GO:0006412","GO:0007093"]},{"accession":"XP_012895484.1","go_terms":["GO:0006412"]},{"accession":"XP_012897736.1","go_terms":["GO:0042254","GO:0031167","GO:0001843","GO:0006412"]},{"accession":"XP_012898424.1","go_terms":["GO:0042273","GO:0071480","GO:1902167","GO:0042256","GO:0006977","GO:0034644","GO:0045727","GO:1902164","GO:0006412","GO:1904803","GO:0032784","GO:0031564","GO:0006354","GO:0006353"]},{"accession":"XP_012898526.1","go_terms":["GO:1902164","GO:1902167","GO:0032784","GO:0006977","GO:1904803","GO:0042273","GO:0031564","GO:0071480","GO:0006354","GO:0006353","GO:0045727","GO:0006412"]},{"accession":"XP_012898828.1","go_terms":["GO:2000032","GO:0090506","GO:0031581","GO:0000028","GO:0034198","GO:0006407"]},{"accession":"XP_012899444.1","go_terms":["GO:0006412"]}],"graph":[["XP_012895749.1","XP_012893677.1",0.83],["XP_012895749.1","XP_012893733.1",0.962],["XP_012895749.1","XP_012893888.1",0.883],["XP_012895749.1","XP_012894020.1",0.893],["XP_012895749.1","XP_012894242.1",0.915],["XP_012895749.1","XP_012894254.1",0.88],["XP_012895749.1","XP_012895182.1",0.91],["XP_012895749.1","XP_012899200.1",0.827],["XP_012895749.1","XP_012899444.1",0.974],["XP_012895749.1","XP_012898424.1",0.825],["XP_012895749.1","XP_012898526.1",0.927],["XP_012895749.1","XP_012898828.1",0.954],["XP_012895749.1","XP_012898915.1",0.917],["XP_012895749.1","XP_012897736.1",0.879],["XP_012895749.1","XP_012895484.1",0.898],["XP_012895749.1","XP_012895948.1",0.843],["XP_012895484.1","XP_012893677.1",0.861],["XP_012895484.1","XP_012893733.1",0.861],["XP_012895484.1","XP_012893888.1",0.892],["XP_012895484.1","XP_012894020.1",0.899],["XP_012895484.1","XP_012894242.1",0.9],["XP_012895484.1","XP_012894254.1",0.893],["XP_012895484.1","XP_012895182.1",0.882],["XP_012895484.1","XP_012899200.1",0.872],["XP_012895484.1","XP_012899444.1",0.884],["XP_012895484.1","XP_012898424.1",0.849],["XP_012895484.1","XP_012898526.1",0.889],["XP_012895484.1","XP_012898828.1",0.898],["XP_012895484.1","XP_012898915.1",0.921],["XP_012895484.1","XP_012897736.1",0.853],["XP_012895484.1","XP_012895948.1",0.861],["XP_012894020.1","XP_012893677.1",0.888],["XP_012894020.1","XP_012893733.1",0.83],["XP_012894020.1","XP_012893888.1",0.878],["XP_012894020.1","XP_012894242.1",0.917],["XP_012894020.1","XP_012894254.1",0.834],["XP_012894020.1","XP_012895182.1",0.88],["XP_012894020.1","XP_012895948.1",0.873],["XP_012894020.1","XP_012897736.1",0.909],["XP_012894020.1","XP_012898424.1",0.843],["XP_012894020.1","XP_012898526.1",0.912],["XP_012894020.1","XP_012898828.1",0.971],["XP_012894020.1","XP_012898915.1",0.921],["XP_012894020.1","XP_012899200.1",0.902],["XP_012894020.1","XP_012899444.1",0.942],["XP_012894254.1","XP_012893677.1",0.871],["XP_012894254.1","XP_012893733.1",0.954],["XP_012894254.1","XP_012893888.1",0.902],["XP_012894254.1","XP_012899200.1",0.824],["XP_012894254.1","XP_012899444.1",0.957],["XP_012894254.1","XP_012898424.1",0.797],["XP_012894254.1","XP_012898526.1",0.87],["XP_012894254.1","XP_012898828.1",0.959],["XP_012894254.1","XP_012898915.1",0.916],["XP_012894254.1","XP_012897736.1",0.902],["XP_012894254.1","XP_012895948.1",0.845],["XP_012894254.1","XP_012894242.1",0.904],["XP_012894254.1","XP_012895182.1",0.881],["XP_012893888.1","XP_012893677.1",0.878],["XP_012893888.1","XP_012893733.1",0.945],["XP_012893888.1","XP_012894242.1",0.912],["XP_012893888.1","XP_012895182.1",0.872],["XP_012893888.1","XP_012895948.1",0.865],["XP_012893888.1","XP_012897736.1",0.915],["XP_012893888.1","XP_012898424.1",0.836],["XP_012893888.1","XP_012898526.1",0.941],["XP_012893888.1","XP_012898828.1",0.965],["XP_012893888.1","XP_012898915.1",0.905],["XP_012893888.1","XP_012899200.1",0.871],["XP_012893888.1","XP_012899444.1",0.95],["XP_012893677.1","XP_012893733.1",0.979],["XP_012893677.1","XP_012894242.1",0.889],["XP_012893677.1","XP_012895182.1",0.871],["XP_012893677.1","XP_012895948.1",0.774],["XP_012893677.1","XP_012897736.1",0.866],["XP_012893677.1","XP_012898424.1",0.779],["XP_012893677.1","XP_012898526.1",0.935],["XP_012893677.1","XP_012898828.1",0.973],["XP_012893677.1","XP_012898915.1",0.892],["XP_012893677.1","XP_012899200.1",0.82],["XP_012893677.1","XP_012899444.1",0.984],["XP_012898915.1","XP_012893733.1",0.976],["XP_012898915.1","XP_012894242.1",0.92],["XP_012898915.1","XP_012895182.1",0.926],["XP_012898915.1","XP_012895948.1",0.899],["XP_012898915.1","XP_012897736.1",0.901],["XP_012898915.1","XP_012898424.1",0.901],["XP_012898915.1","XP_012898526.1",0.891],["XP_012898915.1","XP_012898828.1",0.964],["XP_012898915.1","XP_012899200.1",0.893],["XP_012898915.1","XP_012899444.1",0.971],["XP_012893733.1","XP_012894242.1",0.885],["XP_012893733.1","XP_012895182.1",0.939],["XP_012893733.1","XP_012895948.1",0.964],["XP_012893733.1","XP_012897736.1",0.972],["XP_012893733.1","XP_012898424.1",0.915],["XP_012893733.1","XP_012898526.1",0.939],["XP_012893733.1","XP_012898828.1",0.789],["XP_012893733.1","XP_012899200.1",0.863],["XP_012893733.1","XP_012899444.1",0.616],["XP_012897736.1","XP_012894242.1",0.919],["XP_012897736.1","XP_012895182.1",0.913],["XP_012897736.1","XP_012895948.1",0.832],["XP_012897736.1","XP_012899200.1",0.861],["XP_012897736.1","XP_012899444.1",0.958],["XP_012897736.1","XP_012898424.1",0.834],["XP_012897736.1","XP_012898526.1",0.924],["XP_012897736.1","XP_012898828.1",0.963],["XP_012898526.1","XP_012894242.1",0.942],["XP_012898526.1","XP_012895182.1",0.877],["XP_012898526.1","XP_012895948.1",0.914],["XP_012898526.1","XP_012898424.1",0.86],["XP_012898526.1","XP_012898828.1",0.95],["XP_012898526.1","XP_012899200.1",0.921],["XP_012898526.1","XP_012899444.1",0.944],["XP_012898828.1","XP_012894242.1",0.986],["XP_012898828.1","XP_012895182.1",0.948],["XP_012898828.1","XP_012895948.1",0.972],["XP_012898828.1","XP_012898424.1",0.967],["XP_012898828.1","XP_012899200.1",0.969],["XP_012898828.1","XP_012899444.1",0.945],["XP_012899444.1","XP_012894242.1",0.967],["XP_012899444.1","XP_012895182.1",0.934],["XP_012899444.1","XP_012895948.1",0.98],["XP_012899444.1","XP_012898424.1",0.978],["XP_012899444.1","XP_012899200.1",0.928],["XP_012895948.1","XP_012894242.1",0.883],["XP_012895948.1","XP_012895182.1",0.869],["XP_012895948.1","XP_012898424.1",0.741],["XP_012895948.1","XP_012899200.1",0.796],["XP_012894242.1","XP_012899200.1",0.866],["XP_012894242.1","XP_012898424.1",0.903],["XP_012894242.1","XP_012895182.1",0.878],["XP_012898424.1","XP_012895182.1",0.872],["XP_012898424.1","XP_012899200.1",0.769],["XP_012899200.1","XP_012895182.1",0.876]],"all_go_terms":{"GO:0046677":1,"GO:0002181":2,"GO:0006412":14,"GO:0042254":4,"GO:0000028":2,"GO:0006407":2,"GO:1901194":1,"GO:0032784":3,"GO:1902167":3,"GO:0071480":3,"GO:0006353":3,"GO:0006977":3,"GO:0042273":3,"GO:1904803":3,"GO:1902164":3,"GO:0045727":3,"GO:0031564":3,"GO:0006354":3,"GO:0032543":1,"GO:1990090":1,"GO:0071353":1,"GO:0000027":1,"GO:0000462":2,"GO:0007093":1,"GO:0048821":1,"GO:0022605":1,"GO:0000082":1,"GO:0031929":1,"GO:0031167":2,"GO:0007369":1,"GO:0033077":1,"GO:0006924":1,"GO:0001890":1,"GO:0043065":1,"GO:0002309":1,"GO:0042274":1,"GO:0001843":1,"GO:0042256":1,"GO:0034644":1,"GO:0090506":1,"GO:0031581":1,"GO:2000032":1,"GO:0034198":1},"recipe_readded":[]}