{"hash":"131657128899344207","title":"Amino acid, vitamin, and heme biosynthesis","description":"The proteins are enriched for multiple biosynthetic processes: protoporphyrinogen IX biosynthesis, biotin biosynthesis, histidine and alanine biosynthesis, and heme biosynthesis, with additional signals of antibiotic biosynthesis. This indicates a shared role in producing diverse small-molecule metabolites rather than degradation or signaling. A couple of terms (systemic acquired resistance signaling and cellular response to insulin) are less directly related, but do not outweigh the core biosynthetic theme. Overall, the cluster seems to represent a metabolic biosynthesis module focused on amino acids, vitamins, and heme-related pathways.","confidence":"Medium","size":11,"edges":48,"triangles":112,"max_degree":10,"top_function":"DNA-templated transcription","members":[{"accession":"XP_004344454.2","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_004346261.2","go_terms":["GO:0019491","GO:0048148","GO:0017000","GO:0009450","GO:0009413","GO:0055129","GO:0009102","GO:0019878","GO:0015995","GO:0006782","GO:0006593","GO:0010121","GO:0009447","GO:0019481","GO:0019483","GO:0042450","GO:0009089"]},{"accession":"XP_004347321.1","go_terms":["GO:0019596","GO:0032923","GO:0033611","GO:0009234","GO:0019655","GO:0009436","GO:0019529","GO:0000949","GO:0042372","GO:0042867","GO:0022900","GO:0009099","GO:0009097","GO:0019310","GO:0034077","GO:0006086","GO:0009851","GO:0000950","GO:0000951"]},{"accession":"XP_004348654.2","go_terms":["GO:0019367","GO:0051790","GO:0017000","GO:0051792"]},{"accession":"XP_004364627.1","go_terms":["GO:0036111","GO:0032385","GO:0036112","GO:0008209","GO:0032150","GO:0060009","GO:1901373","GO:0006635","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109"]},{"accession":"XP_004347057.1","go_terms":["GO:0070179","GO:0019499","GO:0009310","GO:0046360","GO:0043278","GO:0018871","GO:0043418","GO:0006565","GO:0006535","GO:0019295","GO:0000162","GO:0070814","GO:0042866","GO:0019346","GO:0019343","GO:0009088","GO:0070689","GO:0009097"]},{"accession":"XP_004344556.1","go_terms":["GO:0019491","GO:0048148","GO:0017000","GO:0009450","GO:0009413","GO:0055129","GO:0009102","GO:0019878","GO:0015995","GO:0006782","GO:0006593","GO:0010121","GO:0009447","GO:0019481","GO:0019483","GO:0042450","GO:0009089","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0046511","GO:0033362"]},{"accession":"XP_004345684.1","go_terms":["GO:0006642","GO:0032504","GO:0046166","GO:0009658","GO:0061621","GO:0006098","GO:0080022","GO:0019563","GO:0006094"]},{"accession":"XP_004347631.1","go_terms":["GO:0019491","GO:0048148","GO:0017000","GO:0009450","GO:0009413","GO:0055129","GO:0009102","GO:0019878","GO:0015995","GO:0006782","GO:0006593","GO:0010121","GO:0009447","GO:0019481","GO:0019483","GO:0042450","GO:0009089"]},{"accession":"XP_004364568.1","go_terms":["GO:0006556","GO:0006730","GO:0009087","GO:0033353"]},{"accession":"XP_004346830.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]}],"graph":[["XP_004348654.2","XP_004344454.2",0.959],["XP_004348654.2","XP_004344556.1",0.898],["XP_004348654.2","XP_004345684.1",0.976],["XP_004348654.2","XP_004346261.2",0.936],["XP_004348654.2","XP_004346830.1",0.93],["XP_004348654.2","XP_004347057.1",0.946],["XP_004348654.2","XP_004347321.1",0.963],["XP_004348654.2","XP_004347631.1",0.881],["XP_004348654.2","XP_004364568.1",0.968],["XP_004348654.2","XP_004364627.1",0.967],["XP_004344556.1","XP_004347631.1",0.821],["XP_004344556.1","XP_004347057.1",0.765],["XP_004344556.1","XP_004345684.1",0.965],["XP_004344556.1","XP_004346261.2",0.852],["XP_004344556.1","XP_004344454.2",0.518],["XP_004344556.1","XP_004364568.1",0.912],["XP_004346261.2","XP_004344454.2",0.715],["XP_004346261.2","XP_004347631.1",0.828],["XP_004346261.2","XP_004347057.1",0.828],["XP_004346261.2","XP_004345684.1",0.746],["XP_004346261.2","XP_004364568.1",0.836],["XP_004346261.2","XP_004364627.1",0.588],["XP_004345684.1","XP_004344454.2",0.944],["XP_004345684.1","XP_004347631.1",0.946],["XP_004345684.1","XP_004347057.1",0.909],["XP_004345684.1","XP_004347321.1",0.991],["XP_004345684.1","XP_004346830.1",0.876],["XP_004345684.1","XP_004364568.1",0.964],["XP_004345684.1","XP_004364627.1",0.978],["XP_004347057.1","XP_004344454.2",0.912],["XP_004347057.1","XP_004346830.1",0.626],["XP_004347057.1","XP_004347321.1",0.901],["XP_004347057.1","XP_004347631.1",0.794],["XP_004347057.1","XP_004364568.1",0.871],["XP_004347057.1","XP_004364627.1",0.894],["XP_004364627.1","XP_004344454.2",0.912],["XP_004364627.1","XP_004346830.1",0.907],["XP_004364627.1","XP_004347321.1",0.69],["XP_004364627.1","XP_004364568.1",0.937],["XP_004347631.1","XP_004344454.2",0.713],["XP_004347631.1","XP_004346830.1",0.792],["XP_004347631.1","XP_004364568.1",0.945],["XP_004347321.1","XP_004344454.2",0.971],["XP_004347321.1","XP_004346830.1",0.896],["XP_004347321.1","XP_004364568.1",0.928],["XP_004364568.1","XP_004344454.2",0.953],["XP_004364568.1","XP_004346830.1",0.899],["XP_004346830.1","XP_004344454.2",0.582]],"all_go_terms":{"GO:0034516":1,"GO:0009862":3,"GO:0042218":3,"GO:0042866":2,"GO:0032869":3,"GO:0000105":3,"GO:0006783":3,"GO:0019442":1,"GO:0006523":3,"GO:0006686":3,"GO:0051591":1,"GO:0015908":3,"GO:0097053":3,"GO:0033362":3,"GO:0019441":3,"GO:0019518":3,"GO:0033512":3,"GO:0033585":3,"GO:0019551":3,"GO:0007219":3,"GO:0009436":2,"GO:0034276":3,"GO:0006532":3,"GO:0046511":3,"GO:0019805":1,"GO:0019448":1,"GO:0019265":1,"GO:0051384":1,"GO:0006571":3,"GO:0006107":3,"GO:0006546":1,"GO:0006782":5,"GO:0044571":1,"GO:0019700":1,"GO:0070903":1,"GO:0043420":1,"GO:0008615":1,"GO:0034354":1,"GO:0042853":3,"GO:0009835":3,"GO:0055089":3,"GO:0018283":1,"GO:0009236":3,"GO:0009102":5,"GO:0019878":5,"GO:0006564":1,"GO:0019550":3,"GO:0006533":3,"GO:0006351":3,"GO:0046724":1,"GO:0009089":3,"GO:0055129":3,"GO:0015995":3,"GO:0019491":3,"GO:0006593":3,"GO:0010121":3,"GO:0009447":3,"GO:0009413":3,"GO:0009450":3,"GO:0042450":3,"GO:0048148":3,"GO:0019481":3,"GO:0019483":3,"GO:0017000":4,"GO:0019310":1,"GO:0000950":1,"GO:0019655":1,"GO:0009099":1,"GO:0034077":1,"GO:0042867":1,"GO:0022900":1,"GO:0032923":1,"GO:0000951":1,"GO:0019529":1,"GO:0009851":1,"GO:0042372":1,"GO:0009097":2,"GO:0019596":1,"GO:0000949":1,"GO:0006086":1,"GO:0009234":1,"GO:0033611":1,"GO:0051792":1,"GO:0019367":1,"GO:0051790":1,"GO:0010111":1,"GO:0072229":1,"GO:0007420":1,"GO:0006550":1,"GO:0008203":1,"GO:0046951":1,"GO:0030435":1,"GO:0036111":1,"GO:0042594":1,"GO:1901373":1,"GO:1901029":1,"GO:0019619":1,"GO:0001889":1,"GO:0014070":1,"GO:1902109":1,"GO:0046356":1,"GO:0008209":1,"GO:0046952":1,"GO:1902860":1,"GO:0051260":1,"GO:0042619":1,"GO:0032150":1,"GO:0036112":1,"GO:0009725":1,"GO:0060612":1,"GO:0060009":1,"GO:0032385":1,"GO:0006635":1,"GO:0019343":1,"GO:0006535":1,"GO:0046360":1,"GO:0009310":1,"GO:0019346":1,"GO:0043418":1,"GO:0019295":1,"GO:0018871":1,"GO:0019499":1,"GO:0000162":1,"GO:0070689":1,"GO:0006565":1,"GO:0043278":1,"GO:0070179":1,"GO:0009088":1,"GO:0070814":1,"GO:0009658":1,"GO:0032504":1,"GO:0006094":1,"GO:0019563":1,"GO:0046166":1,"GO:0006098":1,"GO:0061621":1,"GO:0006642":1,"GO:0080022":1,"GO:0006730":1,"GO:0033353":1,"GO:0009087":1,"GO:0006556":1},"recipe_readded":[]}