{"hash":"420731705450038484","title":"Regulated Intramembrane Proteolysis (RIP) Signaling","description":"The GO terms center on membrane-associated proteolysis (ectodomain and intracellular domain proteolysis) and membrane trafficking (Golgi to plasma membrane, ER-to-cytosol), suggesting regulated intramembrane proteolysis events that generate signaling fragments. The presence of terms related to NFAT signaling and immune regulation supports a signaling role downstream of RIP-like proteolysis. A few phosphate transport terms appear as less central context but do not undermine the main RIP-signaling theme.","confidence":"Medium","size":16,"edges":72,"triangles":125,"max_degree":13,"top_function":null,"members":[{"accession":"XP_012049120.1","go_terms":["GO:0006893"]},{"accession":"XP_012053742.1","go_terms":["GO:0050776","GO:1904211","GO:0051533","GO:0006509","GO:0070886","GO:0031293"]},{"accession":"XP_012046750.1","go_terms":[]},{"accession":"XP_012048007.1","go_terms":[]},{"accession":"XP_012052007.1","go_terms":["GO:0035435","GO:0030643","GO:0048016"]},{"accession":"XP_012050071.1","go_terms":[]},{"accession":"XP_012050847.1","go_terms":["GO:0006656","GO:0006686"]},{"accession":"XP_012050979.1","go_terms":[]},{"accession":"XP_012052014.1","go_terms":["GO:0040027","GO:0006888"]},{"accession":"XP_012052623.1","go_terms":[]},{"accession":"XP_012047756.1","go_terms":[]},{"accession":"XP_012046530.1","go_terms":["GO:0006673"]},{"accession":"XP_012046595.1","go_terms":["GO:1902358","GO:0019344","GO:0000103"]},{"accession":"XP_012049933.1","go_terms":["GO:0001306","GO:0050881","GO:0021523","GO:0050884","GO:0060052","GO:1905045","GO:0051935","GO:0046513","GO:0032964","GO:0044257","GO:0002238","GO:1900148"]},{"accession":"XP_012047039.1","go_terms":["GO:0007625","GO:0060905","GO:0006488","GO:0015811","GO:0080144","GO:1904659","GO:0002088","GO:0034488"]},{"accession":"XP_012051111.1","go_terms":["GO:0035621","GO:0032366","GO:0097036","GO:0035376","GO:0032383","GO:0008206","GO:0030301","GO:0090181"]}],"graph":[["XP_012050847.1","XP_012046530.1",0.529],["XP_012050847.1","XP_012046595.1",0.56],["XP_012050847.1","XP_012046750.1",0.507],["XP_012050847.1","XP_012047039.1",0.563],["XP_012050847.1","XP_012049120.1",0.583],["XP_012050847.1","XP_012049933.1",0.585],["XP_012050847.1","XP_012050071.1",0.543],["XP_012050847.1","XP_012050979.1",0.63],["XP_012050847.1","XP_012052007.1",0.627],["XP_012050847.1","XP_012052014.1",0.503],["XP_012051111.1","XP_012047039.1",0.583],["XP_012051111.1","XP_012047756.1",0.545],["XP_012051111.1","XP_012048007.1",0.526],["XP_012051111.1","XP_012049120.1",0.519],["XP_012051111.1","XP_012050071.1",0.575],["XP_012051111.1","XP_012050979.1",0.555],["XP_012051111.1","XP_012052007.1",0.518],["XP_012051111.1","XP_012052623.1",0.515],["XP_012052623.1","XP_012046750.1",0.605],["XP_012052623.1","XP_012048007.1",0.529],["XP_012052623.1","XP_012049120.1",0.524],["XP_012052623.1","XP_012052014.1",0.506],["XP_012052623.1","XP_012053742.1",0.524],["XP_012047039.1","XP_012046595.1",0.515],["XP_012047039.1","XP_012046750.1",0.625],["XP_012047039.1","XP_012052014.1",0.532],["XP_012047039.1","XP_012050979.1",0.551],["XP_012047039.1","XP_012050071.1",0.528],["XP_012047039.1","XP_012049933.1",0.549],["XP_012047039.1","XP_012047756.1",0.527],["XP_012047039.1","XP_012048007.1",0.572],["XP_012049120.1","XP_012046530.1",0.502],["XP_012049120.1","XP_012046595.1",0.558],["XP_012049120.1","XP_012046750.1",0.588],["XP_012049120.1","XP_012053742.1",0.528],["XP_012049120.1","XP_012050979.1",0.515],["XP_012049120.1","XP_012049933.1",0.529],["XP_012046530.1","XP_012046595.1",0.557],["XP_012046530.1","XP_012047756.1",0.548],["XP_012046530.1","XP_012048007.1",0.513],["XP_012046530.1","XP_012049933.1",0.5],["XP_012046530.1","XP_012050071.1",0.551],["XP_012046530.1","XP_012050979.1",0.513],["XP_012046530.1","XP_012052014.1",0.51],["XP_012046530.1","XP_012053742.1",0.523],["XP_012048007.1","XP_012046595.1",0.525],["XP_012048007.1","XP_012046750.1",0.536],["XP_012048007.1","XP_012049933.1",0.513],["XP_012048007.1","XP_012050979.1",0.525],["XP_012048007.1","XP_012052014.1",0.534],["XP_012048007.1","XP_012053742.1",0.522],["XP_012050071.1","XP_012046595.1",0.51],["XP_012050071.1","XP_012049933.1",0.558],["XP_012050071.1","XP_012052007.1",0.552],["XP_012050071.1","XP_012050979.1",0.538],["XP_012050979.1","XP_012046595.1",0.509],["XP_012050979.1","XP_012046750.1",0.502],["XP_012050979.1","XP_012049933.1",0.603],["XP_012050979.1","XP_012052007.1",0.561],["XP_012050979.1","XP_012052014.1",0.514],["XP_012050979.1","XP_012053742.1",0.505],["XP_012052014.1","XP_012047756.1",0.546],["XP_012052014.1","XP_012053742.1",0.578],["XP_012049933.1","XP_012046595.1",0.578],["XP_012049933.1","XP_012052007.1",0.526],["XP_012049933.1","XP_012053742.1",0.539],["XP_012047756.1","XP_012046595.1",0.501],["XP_012046750.1","XP_012046595.1",0.537],["XP_012046750.1","XP_012052007.1",0.575],["XP_012046750.1","XP_012053742.1",0.625],["XP_012046595.1","XP_012052007.1",0.549],["XP_012046595.1","XP_012053742.1",0.51]],"all_go_terms":{"GO:0006893":1,"GO:0006509":1,"GO:1904211":1,"GO:0031293":1,"GO:0051533":1,"GO:0070886":1,"GO:0050776":1,"GO:0035435":1,"GO:0030643":1,"GO:0048016":1,"GO:0006686":1,"GO:0006656":1,"GO:0006888":1,"GO:0040027":1,"GO:0006673":1,"GO:0000103":1,"GO:1902358":1,"GO:0019344":1,"GO:0001306":1,"GO:0050881":1,"GO:0021523":1,"GO:0051935":1,"GO:0002238":1,"GO:0046513":1,"GO:0050884":1,"GO:1900148":1,"GO:1905045":1,"GO:0060052":1,"GO:0032964":1,"GO:0044257":1,"GO:0007625":1,"GO:0034488":1,"GO:0006488":1,"GO:0080144":1,"GO:1904659":1,"GO:00020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