{"hash":"1476150286200389277","title":"Ubiquitin-Proteasome System Regulation","description":"The dominant GO terms point to regulation of protein turnover via the ubiquitin-proteasome system: deneddylation (COP9 signalosome), multiple deubiquitination activities (K11- and H2A K63-linked), proteasome storage granule assembly, and endopeptidase activity regulation, all of which connect to proteostasis. Some terms touch DNA repair and spliceosome dynamics, which can involve UPS-related regulation, supporting a cohesive theme of ubiquitin-mediated control of protein fate rather than a single isolated function.","confidence":"High","size":11,"edges":42,"triangles":79,"max_degree":10,"top_function":"DNA 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