[{"hash":"538401976948011419","title":"Translation machinery and ribosome biogenesis","description":"Top GO terms emphasize translation in multiple compartments (cytoplasmic and mitochondrial), ribosome biogenesis, and SRP-dependent cotranslational targeting to membranes, including translocation and translational fidelity. This pattern strongly indicates a cluster of proteins involved in ribosome function, translation, and associated protein targeting processes. A couple of non-core terms (cobalamin biosynthesis, bacterial flagellum organization) are present but minority.","confidence":"High","size":22,"edges":50,"triangles":82,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006614","count":2},{"id":"GO:0009236","count":2}]},{"hash":"1754716842984672372","title":"Unknown","description":"The terms mix chromatin-related processes (subtelomeric heterochromatin formation, centromeric cohesion, and histone H4 acetylation) with a variety of disparate metabolic biosynthesis and catabolic processes (glucosamine, mycothiol, ectoine, arginine, putrescine, spermine). Because there isn't a single cohesive functional theme tying these GO terms together, the cluster does not map to a specific biological function.","confidence":"","size":19,"edges":33,"triangles":45,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":6},{"id":"GO:0071962","count":5},{"id":"GO:0006041","count":5},{"id":"GO:0045150","count":5},{"id":"GO:0010125","count":5}]},{"hash":"1363205153077820671","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":4,"triangles":0,"max_degree":3,"top_function":"autophagy","top_go_terms":[{"id":"GO:0009048","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0060816","count":3},{"id":"GO:0033280","count":3}]},{"hash":"1057855616275800458","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitination and ubiquitin-dependent proteolysis (polyubiquitination, autoubiquitination, ERAD), indicating the proteins cluster around tagging substrates for degradation via the ubiquitin-proteasome system. Other terms related to translation and splicing may reflect broader proteostasis connections, but the strongest signal is proteolysis through ubiquitination.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0000209","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":4},{"id":"GO:1903265","count":4}]},{"hash":"952399782946202922","title":"Glycerophospholipid remodeling and biosynthesis","description":"The cluster centers on lipid metabolism terms: remodeling and biosynthesis of glycerophospholipids such as phosphatidylcholine and cardiolipin (and related steps like CDP-diacylglycerol biosynthesis), plus the production of a lipid mediator (platelet activating factor). While there are a few immune and developmental terms in the mix, the lipid-related terms are the strongest connective thread, supporting a label focused on lipid remodeling and biosynthesis rather than a broader, non-specific function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010143","count":2},{"id":"GO:0036151","count":2},{"id":"GO:0035965","count":2},{"id":"GO:2001246","count":2},{"id":"GO:0070970","count":2}]},{"hash":"1364506825701434503","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000480","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0042273","count":2}]},{"hash":"722401613467651427","title":"Immune signaling and ubiquitin-proteasome regulation","description":"Proteins in this cluster are enriched for Fc-epsilon receptor signaling, stimulatory C-type lectin receptor signaling, and T cell receptor signaling, indicating immune activation. At the same time, there is strong representation of ubiquitin-proteasome\u2013related processes (SCF- and APC-dependent degradation, ERAD), plus neddylation and protein import pathways, all pointing to coordinated regulation of protein turnover in immune signaling and cell-cycle contexts. This combination supports a theme of immune signaling intertwined with proteostasis.","confidence":"Medium","size":12,"edges":25,"triangles":27,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0038095","count":8},{"id":"GO:0002223","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0031146","count":8},{"id":"GO:0031145","count":8}]},{"hash":"2289069016970854166","title":"Chromatin remodeling and DNA replication","description":"The cluster shows strong representation of chromatin-related terms (histone exchange, heterochromatin formation, nucleosome mobilization) alongside DNA transaction processes (DNA replication, transcription). While a couple of metabolic and stress-response terms appear, they are less frequent, so the core theme points to chromatin remodeling coupled with DNA processing.","confidence":"High","size":12,"edges":13,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043486","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0032508","count":2},{"id":"GO:0042766","count":2},{"id":"GO:0006098","count":2}]},{"hash":"1029460017861264043","title":"Ubiquitin-dependent proteolysis and cell cycle regulation","description":"Proteins here cluster around ubiquitination and proteasome-mediated degradation, including neddylation, various ubiquitin linkages (K11, K6), SCF- and APC/C-dependent catabolic processes, and ERAD-associated turnover. This points to a core theme of regulated protein turnover and cell cycle control, with a few ancillary terms (peroxisome import, viral process) that are less central to the main function.","confidence":"High","size":12,"edges":34,"triangles":55,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045116","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0070979","count":4},{"id":"GO:0016558","count":4}]},{"hash":"1308288496056144305","title":"DNA Replication and Transcription Machinery","description":"The cluster is dominated by GO terms for DNA replication, DNA-templated transcription, and viral genome replication, with additional terms for cell division and ribosomal large subunit assembly, pointing to core nucleic acid metabolism and production processes. A few terms (cilium movement, dense core vesicle transport, gas vesicle organization) are less aligned with this theme, suggesting possible annotation noise or multifunctional proteins, but the strongest signal is replication/transcription machinery.","confidence":"Medium","size":11,"edges":8,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0019079","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0003341","count":4},{"id":"GO:0006351","count":4}]},{"hash":"1943346820155458786","title":"Mitotic Cell Cycle and Growth","description":"The cluster is dominated by GO terms for mitosis and cell cycle (mitotic cell cycle, mitotic spindle assembly, cell division) along with growth-related signals (multicellular organism growth, TORC1 signaling) and essential cellular logistics (ribosomal subunit export, Golgi-to-ER transport), suggesting a module coordinating cell division with growth rather than neuronal signaling.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0090394","count":4},{"id":"GO:0035264","count":4},{"id":"GO:1904263","count":4},{"id":"GO:0043547","count":4}]},{"hash":"895481104649871635","title":"Signaling and Cell Cycle Coordination","description":"The terms point to a mix of signaling pathway involvement (T cell receptor signaling, Wnt signaling) plus processes tied to cell division (mitotic cell cycle) and membrane trafficking/development (transmembrane transport, membrane addition during cytokinesis, hippocampus development, axonogenesis regulation). The common thread appears to be signaling pathways that coordinate cell growth, division, and differentiation, often with membrane trafficking components. ","confidence":"Medium","size":11,"edges":15,"triangles":7,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":7},{"id":"GO:0090263","count":7},{"id":"GO:0000278","count":5},{"id":"GO:0032258","count":5},{"id":"GO:0021766","count":5}]},{"hash":"571630403939834207","title":"RNA transcription and ribosome biogenesis","description":"The cluster shows strong representation of transcription-related GO terms across RNA polymerases I, II, and III (including RNA-templated transcription and Pol III termination), nucleolar rRNA transcription, and ribosome biogenesis, pointing to a cohesive function in RNA synthesis and ribosome assembly. A couple terms (obsolete oxidation-reduction, some mRNA cleavage) are outliers, but the dominant theme is transcriptional machinery and ribosome production.","confidence":"High","size":10,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0006283","count":2},{"id":"GO:0006379","count":2}]},{"hash":"3922135871547443","title":"DNA repair and stress-response RNA modification","description":"The proteins show enrichment for DNA repair processes (base-excision repair, nucleotide-excision repair) and also stress-related responses (trehalose/glucosylglycerol metabolism, desiccation, heat). The presence of tRNA wobble modification terms suggests RNA modification connected to stress adaptation as well. Together, these imply a cluster focused on nucleic acid maintenance and RNA modification under stress conditions. ","confidence":"Medium","size":10,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":2},{"id":"GO:0006284","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0070415","count":1},{"id":"GO:0051473","count":1}]},{"hash":"1392981485117997798","title":"Ubiquitin-Dependent Proteolysis and Immune Signaling","description":"This cluster centers on ubiquitin-dependent protein catabolic processes (SCF- and APC-complex\u2013mediated) and immune-related signaling pathways (TNF, NF-kappaB, C-type lectin receptor), suggesting a link between targeted protein turnover and inflammatory signaling. The ER-to-Golgi transport term reflects general secretory/trafficking processes that support signaling component processing. Overall, the proteins appear to coordinate proteolysis with innate immune signaling rather than a single, narrow function.","confidence":"Medium","size":10,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":3},{"id":"GO:0031145","count":3},{"id":"GO:0070262","count":2},{"id":"GO:0031954","count":2},{"id":"GO:0006888","count":2}]},{"hash":"836612141655488208","title":"Transcription and DNA Metabolism with Xenobiotic Response","description":"These proteins show enrichment for nuclear gene-expression processes: DNA-templated transcription, transcription termination, and DNA recombination, along with ribosome biogenesis. The accompanying xenobiotic and antibiotic response terms suggest a stress-related transcriptional regulation layer, while a couple of terms likely reflect noise or incidental associations. Overall, the theme centers on transcription/DNA metabolism with a stress-response component.","confidence":"Medium","size":10,"edges":6,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0042493","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0042254","count":2}]},{"hash":"147071338978160818","title":"Genome replication and DNA repair","description":"This cluster is dominated by GO terms related to DNA replication, viral genome replication, UV-damage excision repair, DNA recombination, and SOS response, indicating a cohesive function in genome maintenance, replication, and DNA damage response. Some developmental or organellar terms may reflect multifunctional proteins or annotation spillover, but the core theme centers on genome integrity.","confidence":"High","size":10,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0019079","count":5},{"id":"GO:0070914","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0016558","count":4}]},{"hash":"71216178937968376","title":"Ribosome Biogenesis and Translation","description":"Most top GO terms are centered on ribosome assembly and protein synthesis (translation, cytoplasmic translation, ribosome biogenesis, ribosomal subunit assembly). A few terms relate to DNA repair and retina development but are much less represented, suggesting the core function of this cluster is components of the ribosome and the translation machinery.","confidence":"High","size":10,"edges":35,"triangles":71,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0007093","count":3},{"id":"GO:0042274","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000027","count":2}]},{"hash":"980601726836403324","title":"Multi-lineage differentiation signals","description":"This cluster\u2019s GO terms span differentiation/maturation across erythroid, neural, cardiac, immune and lung lineages (and related regulatory processes), with translation as a basic cellular process. No single pathway connects all terms, suggesting a broad developmental theme.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0045648","count":3},{"id":"GO:0021691","count":2},{"id":"GO:0060975","count":2},{"id":"GO:0007510","count":2}]},{"hash":"106281382861459642","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning oxidative stress and aging-related processes, vascular regulation, renal absorption, pigment cell differentiation, and more, with no single clear theme tying the cluster together. Because of this lack of a cohesive function, a specific, representative label cannot be confidently assigned.","confidence":"","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032876","count":2},{"id":"GO:0055114","count":1},{"id":"GO:0071291","count":1},{"id":"GO:0003069","count":1},{"id":"GO:0010447","count":1}]},{"hash":"1503892906211019006","title":"Proteostasis and vesicle trafficking","description":"This cluster centers on protein folding/refolding by chaperones, ER-associated degradation and proteasomal turnover, SNARE complex disassembly, and ER polarization, all characteristic of protein quality control and secretory pathway trafficking; additional terms indicate broader cellular roles but do not contradict this central theme.","confidence":"Medium","size":9,"edges":9,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0072389","count":3},{"id":"GO:0061166","count":3}]},{"hash":"1797941989885828433","title":"Mitotic division with ribosome biogenesis and ER-Golgi transport","description":"The top GO terms point to mitosis and cell cycle progression (cell division, mitotic cell cycle, microtubule-based movement) alongside ribosome biogenesis and ER-to-Golgi trafficking, suggesting a theme of coordinating cell division with protein synthesis and intracellular transport. Developmental and growth terms (embryonic organ development, multicellular growth) further imply a broader growth program. Overall, the cluster seems linked to mitotic machinery coupled with biosynthetic and trafficking processes, though these proteins may be functionally diverse.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0048568","count":3},{"id":"GO:0035264","count":2}]},{"hash":"1597036246129379291","title":"Cell Cycle and Growth Regulation","description":"The top GO terms cluster around cell proliferation and DNA replication, including cell division, Okazaki fragment processing in mitotic DNA replication, and responses related to G1 DNA damage checkpoints, as well as growth regulation by extracellular signals and multicellular organism growth. While a couple terms touch on peroxisome targeting, stress granule dynamics, or neuronal structure, the dominant theme points to cell cycle control and growth signaling.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0001403","count":1},{"id":"GO:0072432","count":1},{"id":"GO:0021693","count":1},{"id":"GO:0001560","count":1}]},{"hash":"1402940006424463058","title":"Unknown","description":"The represented GO terms span several unrelated biosynthetic and metabolic processes (GPI anchor biosynthesis, glycosylation, thiol-based metabolites mycothiol/bacillithiol, lipopolysaccharide synthesis, and antibiotic biosynthesis), plus general terms like sucrose metabolism and even stress/behavior terms. The lack of a common pathway or function across all proteins makes a single cohesive label inappropriate; therefore Unknown with None confidence. ","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":1},{"id":"GO:0033577","count":1},{"id":"GO:0010125","count":1},{"id":"GO:0005985","count":1},{"id":"GO:0007631","count":1}]},{"hash":"1368939071078707035","title":"Neural-glial gene expression regulation","description":"Top GO terms emphasize transcriptional control and translation regulation, including DNA-templated transcription and initiation/termination of translation, alongside neural-context signals like response to brain-derived neurotrophic factor and glial cell proliferation. While some terms are broader (e.g., chromatin regulation, hematopoietic differentiation), the prevailing pattern points to coordinated gene expression regulation in neural/glial cells.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0045903","count":1},{"id":"GO:2000767","count":1},{"id":"GO:1990416","count":1},{"id":"GO:0000288","count":1}]},{"hash":"958857513451693056","title":"ER-Golgi Vesicle Trafficking and UPR","description":"The cluster shows strong enrichment for secretory pathway functions, including ER-to-Golgi transport, inter-Golgi cisterna transport, SNARE complex disassembly, and ER unfolded protein response, plus ER polarization, indicating a cohesive role in ER\u2013Golgi trafficking and ER stress/quality control. Some mitochondrial membrane insertion activity is present but less central to the core theme.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0072389","count":2},{"id":"GO:0061166","count":2},{"id":"GO:0045899","count":2},{"id":"GO:0001824","count":2},{"id":"GO:0046034","count":2}]},{"hash":"314591362353732893","title":"SCF-mediated ubiquitin proteolysis in meiosis","description":"The cluster is dominated by GO terms for post-translational modification and protein degradation (neddylation, SCF-dependent ubiquitination, K11-linked ubiquitination, proteasomal catabolic processes, and sumoylation) along with meiotic cell cycle regulation terms (metaphase/anaphase transition and sister chromatid movement). This points to a coherent theme: targeted protein turnover governing meiotic progression via the SCF/neddylation-ubiquitin axis, with ancillary roles for related modification pathways. Some less central terms (epithelial differentiation, Fe-S cluster assembly, tRNA modification) appear but do not override the core ubiquitin/proteolysis meiotic signal.","confidence":"High","size":8,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045116","count":2},{"id":"GO:0030855","count":2},{"id":"GO:0016226","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0070979","count":2}]},{"hash":"389855569373661099","title":"Ribosome Biogenesis and Energy Metabolism under Stress","description":"The top GO terms point to ribosome biogenesis and cytochrome complex (respiration) assembly, coupled with cellular responses to oxidative stress and NAD+/NADP+ related metabolism and phosphorylation. This suggests a cohesive cluster centered on protein synthesis and energy production with stress-adaptive regulation, though a few terms (e.g., shoot formation and hemidesmosome assembly) may reflect broader or divergent roles. ","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0017004","count":2},{"id":"GO:0034599","count":2},{"id":"GO:0006797","count":1},{"id":"GO:0019674","count":1}]},{"hash":"990969648755843472","title":"RNA processing and translation regulation","description":"The cluster is dominated by GO terms related to post-transcriptional control: splicing via the spliceosome, mRNA polyadenylation/deadenylation regulation, mRNA stabilization, and formation of the translation preinitiation complex, as well as miRNA-mediated translational silencing. While a term for small-subunit processome assembly hints ribosome biogenesis, the overall pattern centers on mRNA maturation and control of translation, suggesting a cohesive theme of RNA processing linked to translation regulation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0016556","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0010610","count":2}]},{"hash":"1243107292878594372","title":"Unknown","description":"The GO terms span translation, muscle contraction regulation, pheromone response, Golgi vesicle budding, metal ion transport (copper, manganese, potassium), calcium-dependent exocytosis, and immune differentiation. Only a few items touch on muscle biology, while many others point to distinct cellular processes, so there isn\u2019t a coherent shared function to label the cluster. ","confidence":"","size":8,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0031448","count":1},{"id":"GO:0000749","count":1},{"id":"GO:0048194","count":1},{"id":"GO:0006825","count":1}]},{"hash":"1031716123596047828","title":"Oxidative stress response and redox homeostasis","description":"The cluster is dominated by GO terms linked to detoxification of oxidants, cellular response to oxidative stress, and maintenance of redox balance (including protein deglutathionylation), suggesting a cohesive redox/homeostasis function. Some metabolic and transporter-related terms appear, but the core signal centers on managing oxidative stress and redox state.","confidence":"High","size":8,"edges":18,"triangles":21,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":4},{"id":"GO:0034599","count":3},{"id":"GO:2000651","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0003147","count":3}]},{"hash":"1866033036280421680","title":"DNA replication and mitotic chromosome maintenance","description":"The top GO terms cluster around DNA replication, cell division, centromeric chromatin assembly (CENP-A), sister chromatid cohesion, and microtubule severing, which together point to replication-associated processes and mitotic chromosome maintenance/segregation. Some terms related to ER-to-Golgi transport/ERAD appear but seem ancillary to the core theme. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0000724","count":3},{"id":"GO:0030433","count":2}]},{"hash":"1584891606763046927","title":"Growth signaling and development with antiviral responses","description":"The top GO terms point to broad signaling networks spanning development (lung morphogenesis, axonogenesis, long-term potentiation), KIT signaling, receptor turnover, and stress responses including apoptosis and antiviral pathways. This suggests a cohesive cluster centered on signals that regulate growth, differentiation, and cellular responses to stress, rather than a single narrow function.","confidence":"Medium","size":8,"edges":24,"triangles":35,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060425","count":8},{"id":"GO:0001403","count":8},{"id":"GO:0038109","count":8},{"id":"GO:0050771","count":8},{"id":"GO:0032801","count":8}]},{"hash":"1714037553185336188","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by translation-related GO terms (translation, translational initiation/termination, cytoplasmic translation, selenocysteine incorporation) and rRNA maturation (SSU-rRNA processing), indicating proteins involved in ribosome assembly and protein synthesis. Some outlier terms like response to antibiotic may reflect stress-related connections but do not override the core theme.","confidence":"High","size":8,"edges":25,"triangles":41,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0046677","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0001514","count":2},{"id":"GO:0014009","count":2}]},{"hash":"1162130297137452030","title":"Ribosome biogenesis and translation with organelle dynamics","description":"This cluster is dominated by translation-related GO terms: tRNA modification, cytoplasmic translation, and ribosomal large subunit export from the nucleus, pointing to ribosome biogenesis and function. Additional terms indicate organelle-related processes and trafficking (mitochondrial membrane organization, mitochondrial fission, protein targeting to vacuole) as well as cell division/fusion aspects, suggesting a broader module that links protein synthesis with organelle maintenance and cellular remodeling in yeast.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006400","count":2},{"id":"GO:1901001","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0006623","count":2},{"id":"GO:0000747","count":2}]},{"hash":"1591313451645563065","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":13,"triangles":8,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0034247","count":4},{"id":"GO:0045292","count":4},{"id":"GO:0006378","count":4},{"id":"GO:0061158","count":3},{"id":"GO:0098789","count":3}]},{"hash":"898320841717073853","title":"mRNA processing and translation regulation","description":"This cluster centers on post-transcriptional mRNA processing and translational control, with terms for mRNA modification, poly(A) tail regulation, splicing regulation, stability, preinitiation complex formation, miRNA-mediated silencing, and inhibition of translation, indicating proteins involved in how mRNA is processed and whether it is translated.","confidence":"High","size":8,"edges":6,"triangles":1,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0016556","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0010610","count":4},{"id":"GO:0001825","count":4},{"id":"GO:0034462","count":4}]},{"hash":"1580101500951760993","title":"RNA Pol I/II Transcription Initiation","description":"The strongest signals in this cluster point to transcription initiation and regulation for RNA polymerase I and II (e.g., initiation at Pol I promoter, Pol II transcription preinitiation complex assembly, open complex formation). Additional terms suggest related nuclear processes (DNA replication, RNA processing), but the core cluster aligns best with transcription initiation machinery for Pol I/II.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042790","count":1},{"id":"GO:1901581","count":1},{"id":"GO:0045898","count":1},{"id":"GO:0006361","count":1},{"id":"GO:0017038","count":1}]},{"hash":"1982721348771936484","title":"Developmental Gene Expression and Cell Cycle","description":"This cluster shows enrichment for DNA replication, DNA-templated transcription, and mitotic cell cycle terms, together with several developmental processes (forebrain development, neural tube closure, skeletal system development, multicellular organism development). The combination suggests proteins that coordinate cell proliferation and gene regulation with embryonic/developmental programs, pointing to a developmental proliferation/gene-expression module. There are also weaker signals of stress-induced apoptosis, but developmental and cell-cycle functions are most prominent.","confidence":"Medium","size":7,"edges":6,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0001403","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0070059","count":4},{"id":"GO:0006349","count":4}]},{"hash":"899495964501100813","title":"Telomeric/Subtelomeric Heterochromatin Formation","description":"The top terms cluster around heterochromatin formation at telomeres and subtelomeric regions, including silent mating-type cassette heterochromatin, and regulation of chromatin silencing at telomeres. This points to a chromatin state maintenance module focused on end- and mating-type locus silencing, with some association to DNA replication processes. Confidence reflects a coherent chromatin-related theme despite some noisy/obsolete terms.","confidence":"High","size":7,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031939","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0030466","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0031647","count":1}]},{"hash":"1122047383324830191","title":"Unknown","description":"The terms across this cluster are highly diverse, with only weak connections. Some entries point to metal ion homeostasis (manganese/copper), others to calcium-dependent exocytosis and muscle/heart function, while several terms involve immune signaling (T cell receptor), developmental signaling (Wnt), and pheromone-induced conjugation. There isn\u2019t a single coherent biological theme tying these proteins together, and the cluster\u2019s sparse connectivity supports labeling it Unknown.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071287","count":2},{"id":"GO:0010738","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0031448","count":1}]},{"hash":"24490152421751396","title":"RNA Pol II Transcription and Ribosome Biogenesis","description":"These proteins are predominantly linked to RNA polymerase II\u2013driven transcription (initiation, promoter clearance, elongation) and to ribosome biogenesis (SSU-rRNA maturation, ribosome assembly). The convergence of transcription-related GO terms with ribosome biogenesis terms suggests a cluster centered on transcriptional machinery and ribosome production rather than a single isolated function. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042795","count":2},{"id":"GO:0006367","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0050434","count":1}]},{"hash":"543337600671503255","title":"Nuclear DNA replication and RNA processing","description":"This cluster shows enrichment for GO terms centered on nuclear functions: DNA replication, chromatin silencing/heterochromatin formation, histone mRNA metabolism, tRNA processing, spliceosome-mediated mRNA splicing and snRNP assembly, mRNA decapping/deadenylation, and nuclear import. The overall theme is genome maintenance and RNA maturation within the nucleus, rather than cytosolic processes, supporting a coherent nuclear module despite mixed specific terms.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0030466","count":2},{"id":"GO:0008334","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0070317","count":1}]},{"hash":"1493791548681215649","title":"Ubiquitin-Dependent Proteolysis in Cell Cycle","description":"The cluster shows strong signals for ubiquitin-mediated protein catabolism (K11- and K48-linked ubiquitination, ubiquitin-dependent proteolysis) and cell-cycle\u2013related degradation (anaphase-promoting complex\u2013dependent catabolic process, cell division), suggesting coordination of protein turnover with mitotic progression. Peroxisomal import and dosage compensation terms appear as minor associations rather than core themes. Thus the label captures the core function of ubiquitin-driven proteolysis linked to cell-cycle regulation. ","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0038018","count":1},{"id":"GO:0016558","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0070979","count":1},{"id":"GO:0060816","count":1}]},{"hash":"793981603630474238","title":"Fungal pheromone-regulated morphogenesis","description":"The cluster's top GO terms center on yeast-like morphogenesis driven by pheromone signaling, including pseudohyphal and invasive growth and parasexual reproduction, with regulation of transcription by pheromones and DNA replication. While a few terms appear unrelated (e.g., T cell activation, melanocyte proliferation), the dominant theme is fungal pheromone-responsive morphogenesis, making this label appropriate.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:1990277","count":1},{"id":"GO:0007329","count":1},{"id":"GO:0001403","count":1},{"id":"GO:0007124","count":1}]},{"hash":"2021918230249972218","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":11,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":1},{"id":"GO:0000472","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0000480","count":1}]},{"hash":"1369045449145951073","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0000465","count":1},{"id":"GO:0042273","count":1}]},{"hash":"1344437175367911921","title":"Unknown","description":"The GO terms span sarcomere organization, exocytosis, translation, apoptotic signaling, microvillus regulation, and adhesion, with no single cohesive function tying them together, so there is no clear theme for a reliable label.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0071320","count":2},{"id":"GO:0002181","count":1},{"id":"GO:0046632","count":1},{"id":"GO:0008625","count":1}]},{"hash":"1926741479403966402","title":"Chromatin Regulation During Mitosis","description":"The cluster shows enrichment for histone modifications (H3-K79 and H3-K27 methylation), K11-linked ubiquitination, and processes linked to the anaphase-promoting complex and mitotic cell cycle, suggesting a theme of chromatin state control coupled with mitotic progression. These terms point to epigenetic regulation that supports cell division, aligning with transcriptional activity in the nucleus and APC-mediated proteolysis. Some translation-related terms may be peripheral noise in this small set. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0070979","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0031145","count":2}]},{"hash":"1359511358095816026","title":"ER Stress and Membrane-Targeted Protein Folding","description":"The cluster is dominated by terms related to unfolded protein response and chaperone-assisted refolding, plus GO terms for SRP-dependent and post-translational targeting to membranes, pointing to a cohesive role in protein quality control and trafficking at the ER/membranes. Some terms (e.g., karyogamy) are less obviously related, but the main theme centers on managing protein folding under stress and directing proteins to membranes.","confidence":"Medium","size":6,"edges":9,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0034620","count":1},{"id":"GO:0016226","count":1},{"id":"GO:1903382","count":1},{"id":"GO:0070389","count":1},{"id":"GO:0006616","count":1}]},{"hash":"1632059228274647962","title":"Mitotic spindle and microtubule organization","description":"The cluster is dominated by microtubule-focused terms: microtubule nucleation, cytoplasmic microtubule organization, mitotic spindle pole body duplication, mitotic cytokinesis, and cell division, which together point to roles in microtubule dynamics during mitosis and cell division. Neuron migration also relies on microtubules, supporting a broader cytoskeletal theme, while other terms may reflect secondary regulatory or signaling links. Overall, the core function suggested is microtubule organization associated with mitosis and cellular movement.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090529","count":2},{"id":"GO:0007020","count":2},{"id":"GO:0031122","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0071353","count":2}]},{"hash":"1516852994791723458","title":"Post-transcriptional RNA processing and regulation","description":"These proteins cluster around RNA maturation and control of mRNA fate: splicing via the spliceosome, mRNA polyadenylation/shortening, stabilization/destabilization, translation initiation, and miRNA-mediated silencing. The presence of small-subunit processome assembly and translation preinitiation complex formation supports roles in ribonucleoprotein maturation and translation control, with blastocyst formation reflecting developmental regulation linked to mRNA processing.","confidence":"High","size":6,"edges":10,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0016556","count":2}]},{"hash":"437459135637510339","title":"Nuclear transport and protein localization","description":"GO terms cluster around nuclear transport and intracellular localization (RNA export, NLS-based import, nuclear inner membrane, Golgi localization) with a note of ubiquitin-dependent degradation, suggesting a set of proteins involved in trafficking and turnover rather than a single pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006405","count":1},{"id":"GO:0033132","count":1},{"id":"GO:0000061","count":1},{"id":"GO:0090526","count":1},{"id":"GO:0036228","count":1}]},{"hash":"2238898588594680594","title":"Neural and embryonic development with transcriptional regulation","description":"This group shows strong emphasis on developmental processes, including DNA-templated transcription, forebrain development, neural tube closure, skeletal system development, and multicellular organism development, along with mitotic cell cycle activity. While stress-response terms (ER stress\u2013related apoptosis and cadmium response) appear, the dominant theme is embryonic/neural development governed by transcriptional programs.","confidence":"Medium","size":6,"edges":5,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0001403","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0070059","count":4},{"id":"GO:0006349","count":4}]},{"hash":"1734526547900379688","title":"Unknown","description":"Top terms show no single cohesive function; metabolism (pentose phosphate/uridine ribose) and RNA processing appear in isolation from development and cell-cycle terms, with only two edges and no triangles, indicating weak connectivity. Therefore no clear common theme can be assigned to this small cluster.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006098","count":1},{"id":"GO:0046109","count":1},{"id":"GO:0009052","count":1},{"id":"GO:0006014","count":1},{"id":"GO:0031053","count":1}]},{"hash":"522886245062833755","title":"Meiotic DNA replication and chromosome dynamics","description":"Most top GO terms relate to DNA replication (DNA replication, strand elongation, unwinding, MCM complex assembly, premeiotic DNA replication) and meiotic processes (female gamete generation, late meiotic recombination nodules). The combination suggests a cluster enriched for replication machinery acting during meiosis and associated chromosomal organization (heterochromatin formation). A few terms like photosynthesis and cilium movement appear as non-core annotations and don't override the primary theme.","confidence":"High","size":6,"edges":5,"triangles":1,"max_degree":4,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0006271","count":3},{"id":"GO:0006268","count":3},{"id":"GO:0015979","count":3},{"id":"GO:0006279","count":3},{"id":"GO:0007292","count":3}]},{"hash":"702478790116579933","title":"DNA Repair and Recombination","description":"These proteins cluster around DNA repair and replication/recombination processes: interstrand cross-link repair, DNA strand displacement, and resolution of mitotic recombination intermediates indicate repair of DNA damage and recombination events. Telomere maintenance via recombination and camptothecin response reinforce genome stability roles; a few terms related to development or circadian regulation appear unrelated to the core theme and may reflect broader expression contexts, but do not dominate the cluster. Overall, the dominant theme is DNA repair and recombination.","confidence":"Medium","size":6,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0036297","count":2},{"id":"GO:0000732","count":1},{"id":"GO:0071140","count":1},{"id":"GO:0072757","count":1},{"id":"GO:0006268","count":1}]},{"hash":"700279679734525970","title":"Unknown","description":"The GO terms are highly diverse and include cellular responses to xenobiotic stimuli and interleukin-4, protein folding, cell cycle regulation, and even unrelated or obsolete annotations like placenta development. There is no clear, unified function that ties the cluster together, so a specific label isn\u2019t justifiable. ","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006457","count":1},{"id":"GO:0051973","count":1},{"id":"GO:0071353","count":1},{"id":"GO:0035690","count":1},{"id":"GO:0032516","count":1}]},{"hash":"1085881967761508167","title":"ER Stress and Protein Folding","description":"The cluster centers on ER-related proteostasis: protein folding in the ER, ER stress response, and protein repair. These GO terms (GO:0034975, GO:0034976, GO:0030091) point to quality control of proteins within the secretory pathway, while oxidative stress response (GO:0034599) suggests broader cellular stress adaptation. A weaker signal for viral process and nuclear transport regulation is present but not dominant, so the overall theme is ER-associated proteostasis under stress.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034599","count":1},{"id":"GO:1903206","count":1},{"id":"GO:0006662","count":1},{"id":"GO:0016032","count":1},{"id":"GO:0055114","count":1}]},{"hash":"210896213135760333","title":"Transcription and ribosome biogenesis","description":"This cluster is dominated by GO terms related to transcription by RNA polymerases I, II, and III, RNA-templated transcription, transcription elongation/termination, and ribosome biogenesis, pointing to a core gene-expression machinery theme. The meiosis-related and morphogenesis terms appear as outliers and do not define the main function of the group.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051026","count":1},{"id":"GO:0007129","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0006360","count":1},{"id":"GO:0042254","count":1}]},{"hash":"2080977255860758509","title":"DNA Replication and Chromosome Segregation","description":"The dominant GO terms point to DNA replication processes (DNA strand elongation, replication fork progression) and mitotic chromosome handling (sister chromatid segregation, recombination regulation, rDNA maintenance). A few terms about protein folding or responses to IL-4/xenobiotic stimuli appear as minor annotations, but the core cluster theme is replication and mitosis.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043007","count":2},{"id":"GO:0000070","count":1},{"id":"GO:0006271","count":1},{"id":"GO:0006457","count":1},{"id":"GO:0097046","count":1}]},{"hash":"1913271228957399629","title":"RNA Polymerase-Driven Transcription and Ribosome Biogenesis","description":"Most terms point to transcription by RNA polymerases I-III, plus ribosome biogenesis and chromatin remodeling (nucleosome disassembly). This suggests a cluster of proteins tied to transcriptional machinery and ribosome production, with a minor incidental term (tubulin deacetylation regulation).","confidence":"High","size":6,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042797","count":1},{"id":"GO:0006360","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0006366","count":1}]},{"hash":"1354824202757450285","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0046898","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0045647","count":1},{"id":"GO:0097011","count":1}]},{"hash":"1348097475992036306","title":"Chromosome segregation during mitosis and meiosis","description":"This cluster\u2019s GO terms center on mitotic sister chromatid segregation, meiotic chromosome separation, homologous chromosome segregation, and chromatin organization, indicating a shared role in chromosome dynamics during cell division; a few catabolic terms appear as outliers but do not outweigh the core theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":1},{"id":"GO:0030574","count":1},{"id":"GO:0034724","count":1},{"id":"GO:0035551","count":1},{"id":"GO:0034396","count":1}]},{"hash":"505971365443683126","title":"Axon guidance and synaptic signaling","description":"The majority of GO terms point to neuronal processes\u2014axonogenesis regulation, axon extension, excitatory postsynaptic potentials, ephrin receptor signaling, and related cytoskeletal changes\u2014suggesting a cluster of proteins involved in neuronal connectivity and synaptic signaling. Some terms like mitotic cell cycle and T cell receptor signaling appear peripheral, but the dominant theme is axon guidance and synaptic signaling.","confidence":"Medium","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0043366","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0031647","count":3}]},{"hash":"2299325662864199560","title":"Nuclear RNA processing and ribosomal protein import","description":"The cluster centers on nuclear transport of RNA- and ribosome-related components (NLS-bearing, hnRNP/snRNP, and ribosomal protein import) and RNA-processing activities like tRNA processing, suggesting a cohesive theme of nucleocytoplasmic transport and ribosome biogenesis. Some regulators of protein desumoylation and GTPase activity appear related, indicating linked control of transport and protein turnover; a kinetochore localization term also fits into nuclear-coupled processes. ","confidence":"High","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0006608","count":2},{"id":"GO:0042176","count":2},{"id":"GO:0034501","count":2}]},{"hash":"973068236053298390","title":"RNA Pol II Transcription Regulation","description":"Most top GO terms describe regulation of transcription by RNA polymerase II, including promoter assembly and stress-induced transcription control. A few terms touch chromatin modification or unrelated processes, but the dominant signal remains Pol II transcription regulation.","confidence":"High","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0061408","count":5},{"id":"GO:0043457","count":5},{"id":"GO:0042766","count":5},{"id":"GO:0045898","count":5}]},{"hash":"86260199519197709","title":"Translational Regulation and RNA Processing","description":"Based on the GO terms, translation is the dominant function (GO:0006412 appears four times), with supporting signals for regulation of translation and translational fidelity. Additional terms point to RNA metabolism activities such as rRNA maturation (SSU-rRNA processing), RNA folding, and RNA splicing regulation, suggesting these proteins coordinate ribosome biogenesis and translation with RNA processing steps. Overall, the cluster appears to group factors involved in translation control and RNA maturation rather than disparate functions.","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0045787","count":1},{"id":"GO:0006417","count":1},{"id":"GO:0009615","count":1},{"id":"GO:0000462","count":1}]},{"hash":"309774706344225302","title":"ER-Golgi trafficking and microtubule organization","description":"The proteins appear linked to vesicle transport between the ER and Golgi, onward to the plasma membrane, and to cytoskeletal processes like microtubule nucleation and organization, suggesting a theme of intracellular trafficking coupled to membrane localization and cytoskeletal dynamics, despite some diverse GO terms.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071340","count":1},{"id":"GO:0006621","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0006890","count":1},{"id":"GO:0090004","count":1}]},{"hash":"772175026221279792","title":"Plant pollen development and meiotic DNA repair","description":"The terms strongly point to plant reproductive biology (pollen development and embryo sac development) together with meiotic genome maintenance (double-strand break repair, meiotic recombination, DNA replication). The accompanying proteostasis terms (protein folding, unfolded protein response, ubiquitin-proteasome quality control) suggest coordinated nuclear quality control during this developmental stage. An outlier term related to animal neural patterning may be annotation noise.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006302","count":1},{"id":"GO:0007131","count":1},{"id":"GO:0009555","count":1},{"id":"GO:0009553","count":1},{"id":"GO:0071630","count":1}]},{"hash":"1652379473507813590","title":"Ubiquitination and Trafficking Regulation","description":"These proteins cluster around post-translational modification processes (deubiquitination and sumoylation) and regulation of intracellular trafficking (GPCR internalization and clathrin-mediated endocytosis), with links to organelle dynamics (mitochondrial fusion) and stress responses (ER stress\u2013related apoptosis and xenobiotic response). This combination suggests a cohesive theme of coordinating protein turnover and membrane trafficking in response to cellular stress.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0016925","count":3},{"id":"GO:0033132","count":3},{"id":"GO:1903071","count":3},{"id":"GO:0017085","count":3}]},{"hash":"1642265579422534238","title":"Diverse development and morphogenesis","description":"The GO terms point to broad developmental processes across tissues and species, including neural patterning (spinal cord neuron fate, oculomotor nerve formation), organ morphogenesis (ureteric bud branching, floral meristem maintenance, osteoblast development), and general transcription necessary for differentiation (RNA polymerase II\u2013mediated transcription). This suggests a broad theme of development and differentiation rather than a single specific pathway, so a label centered on diverse developmental roles is most representative.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":3},{"id":"GO:0021520","count":2},{"id":"GO:0021623","count":2},{"id":"GO:0035623","count":2},{"id":"GO:0060580","count":2}]},{"hash":"1252265507597599167","title":"Nuclear transcription and RNA processing with DNA repair","description":"Top terms indicate a cohesive theme of nuclear transcription initiation and RNA processing, coupled with transcription-coupled DNA repair and mRNA decay pathways, with additional signals of genome maintenance under stress (UV, hypoxia). While a stress granule term touches cytoplasmic localization, the dominant pattern centers on transcriptional machinery and RNA processing tied to DNA damage response. ","confidence":"High","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0017038","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0001113","count":4},{"id":"GO:0000184","count":4},{"id":"GO:1903608","count":4}]},{"hash":"1002419600648957262","title":"Ribosome Biogenesis and Stress Signaling","description":"The cluster is driven by ribosome biogenesis and ribosomal subunit export terms, indicating a core link to ribosome assembly. Several terms also point to stress responses (xenobiotic and hyperosmotic) and JNK cascade regulation, suggesting a connection between ribosome production and stress-activated signaling pathways. While some terms are less related, the dominant theme combines ribosome assembly with cellular stress responses.","confidence":"Medium","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010738","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006972","count":2},{"id":"GO:0046330","count":2}]},{"hash":"370942983891240310","title":"Actin Cytoskeleton and Muscle Development","description":"The prominent GO terms cluster around actin-related processes (Arp2/3-mediated actin nucleation, actin cortical patch localization, and actomyosin contractile ring contraction) and skeletal muscle assembly/development, suggesting the proteins work together in actin filament dynamics and muscle formation. Some terms appear obsolete or unrelated, but the core signal points to actin cytoskeleton remodeling in muscle cells.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044829","count":2},{"id":"GO:0030240","count":1},{"id":"GO:0043982","count":1},{"id":"GO:0051666","count":1},{"id":"GO:0000916","count":1}]},{"hash":"198375219951072021","title":"Chromatin-Directed Transcription and RNA Processing","description":"The top terms cluster around histone methylation (H3-K4, H3-K79) and DNA-templated transcription, along with mRNA processing and regulation of mRNA stability, pointing to a functional group involved in chromatin modification and gene expression control. Some stress-related terms appear, but the core theme is chromatin modification linked to transcription and RNA processing.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034729","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0050830","count":2}]},{"hash":"608815872857813821","title":"Proteostasis and ER stress response","description":"The dominant GO terms point to protein quality control: ubiquitin-proteasome\u2013mediated degradation, protein refolding, and responses to unfolded proteins in the endoplasmic reticulum, suggesting a cluster focused on maintaining proteome integrity under stress. Some related terms (redox homeostasis, proliferation) may reflect broader cellular stress adaptations, but the core theme remains proteostasis and ER-related signaling.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0071630","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0042026","count":1}]},{"hash":"1065097134536316502","title":"Transcription and chromatin regulation","description":"The terms show a core theme of DNA-templated transcription and chromatin/heterochromatin regulation (e.g., rDNA heterochromatin formation and regulation of silent mating-type cassette heterochromatin). While there are some unrelated or obsolete terms and a few outliers, the dominant signal points to transcriptional control linked with chromatin dynamics. Confidence in this label is Medium.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0031647","count":1},{"id":"GO:0061198","count":1},{"id":"GO:0000083","count":1},{"id":"GO:0045149","count":1}]},{"hash":"2587622485196375","title":"DNA Replication & Transcription Machinery","description":"The top GO terms cluster around core DNA metabolism and transcription initiation, including DNA replication, primer synthesis, and RNA polymerase II promoter open complex formation/initiation. Additional terms referring to UV protection and hypoxia response suggest coordinated stress-related regulation of these processes. Some terms (e.g., DNA methylation/restriction-modification) may reflect mixed origins, but the dominant signal points to replication and transcription machinery with regulatory context.","confidence":"Medium","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0001113","count":2},{"id":"GO:0000184","count":2},{"id":"GO:0009650","count":2},{"id":"GO:0001666","count":2}]},{"hash":"1600635113913558774","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006295","count":2},{"id":"GO:0009435","count":1},{"id":"GO:0046939","count":1},{"id":"GO:0006220","count":1},{"id":"GO:0046940","count":1}]},{"hash":"793252112407623280","title":"RNA Splicing and Translation Initiation","description":"This cluster is driven by RNA processing and translation control: spliceosome-mediated splicing, spliceosomal complex assembly, and small-subunit processome assembly point to RNA maturation, while formation of the translation preinitiation complex and miRNA-mediated translational silencing indicate regulation of protein synthesis. Additional terms on mRNA modification and stress-responsive mRNA stability reinforce a post-transcriptional regulatory theme linked to cell division, supporting a cohesive RNA processing/translation control cluster.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":1},{"id":"GO:0000245","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0016556","count":1}]},{"hash":"1884645407070610797","title":"RNA Polymerase II/III Transcription Initiation Complexes","description":"This cluster is dominated by GO terms for transcription initiation and preinitiation complex assembly of RNA polymerases II and III (DNA-templated transcription initiation; RNA Pol II/III preinitiation complex assembly), indicating proteins involved in assembling the transcription start machinery. A few other low-frequency terms are likely incidental. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051123","count":2},{"id":"GO:0006352","count":2},{"id":"GO:0009736","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0009435","count":1}]},{"hash":"174184205406943114","title":"Cerebellar development and neural differentiation","description":"Most top GO terms point to neural development: cerebellar cortex formation, Bergmann glial differentiation, and embryonic cranial skeleton morphogenesis. The inclusion of axon regeneration and protein import supports active neural growth and cellular trafficking. While insulin signaling and T cell signaling appear, they are secondary to the cerebellar development theme, so the cluster best maps to cerebellar neural development rather than a single metabolic or immune pathway.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0060020","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0021697","count":3}]},{"hash":"186883837446287555","title":"Unknown","description":"The terms span metabolism (insulin signaling, gluconeogenesis), stress and apoptosis, transcription, cell cycle, and broad developmental processes, with no single cohesive function tying them together; several GO terms are obsolete, and the cluster has very limited connectivity, so a reliable specific label cannot be assigned. ","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035948","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0070059","count":2}]},{"hash":"1424131540416606741","title":"Translation and RNA surveillance","description":"The top GO terms cluster around translation machinery (translation, ribosome assembly/disassembly, ribosomal subunit dynamics, translational termination) and multiple RNA quality-control pathways (NMD, nonstop decay, non-stop decay, nonfunctional rRNA decay, RNA surveillance), indicating a cohesive function in ribosome-associated translation and mRNA decay, with a minor incidental developmental term (endoderm development) that is less representative of the cluster\u2019s core role.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000027","count":1},{"id":"GO:0007492","count":1},{"id":"GO:0070651","count":1},{"id":"GO:0000184","count":1}]},{"hash":"748386875751270345","title":"SRP-dependent cotranslational membrane targeting","description":"The top GO terms cluster around SRP-dependent cotranslational protein targeting to membranes (three related terms), pointing to roles in directing nascent polypeptides to membranes, likely the ER. The additional transport-related terms (cadmium import into vacuole, thiamine transport, xenobiotic export, fatty acid import into peroxisome, ceramide translocation, bile acid secretion) suggest broader membrane trafficking and lipid-associated transport. Overall, the cluster appears to reflect membrane-targeting and vesicular/transport roles.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006614","count":1},{"id":"GO:0006617","count":1},{"id":"GO:0006616","count":1},{"id":"GO:0036249","count":1},{"id":"GO:0032782","count":1}]},{"hash":"85121228934877899","title":"Developmental Translational Regulation","description":"This cluster centers on GO terms related to translation initiation and reinitiation, indicating a core theme of translational control. The presence of stem cell and neuron differentiation terms (germarium-derived cystoblast division, stem cell differentiation, neuron differentiation) suggests this translational control is engaged in developmental processes. Additional terms about proteasomal degradation and DNA damage recognition fit general cellular regulation during development but are secondary to the translational regulation signal. Overall, the pattern points to proteins involved in regulating translation during development. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0048142","count":1},{"id":"GO:0048863","count":1},{"id":"GO:0032436","count":1},{"id":"GO:0000715","count":1}]},{"hash":"1659309760515043072","title":"SRP/Sec-mediated membrane targeting and secretion","description":"The dominating GO terms point to targeting and transport of proteins to membranes and secretion via SRP-dependent cotranslational targeting and Sec translocon pathways, indicating membership in the secretory/membrane-targeting machinery. A few other single-term items are incidental noise, but the core theme is clear.","confidence":"High","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006605","count":1},{"id":"GO:0031204","count":1},{"id":"GO:0043952","count":1},{"id":"GO:0006616","count":1},{"id":"GO:0009306","count":1}]},{"hash":"1265321082301735371","title":"Unknown","description":"There are no GO terms provided to guide a functional label, and the cluster has minimal connectivity (one edge, no triangles) with five proteins, making it impossible to extract a shared function or theme. Without enriched terms, labeling is not supported by the data.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"843427573644039350","title":"Muscle development and calcium signaling","description":"These proteins cluster around muscle-related functions, including skeletal muscle fiber development, regulation of cardiac muscle hypertrophy, mesoderm development, and regulation of postsynaptic calcium, which together point to muscle differentiation and calcium-mediated signaling as a core theme. Some outlier terms (DNA replication, meiotic processes, brassinosteroid signaling) appear, but they do not outweigh the muscle-centric signals.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0099566","count":4},{"id":"GO:0098609","count":4},{"id":"GO:1903244","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0016576","count":4}]},{"hash":"651553870977949924","title":"Rab GTPase Signaling and Geranylgeranylation","description":"Most of the terms point to Rab protein signal transduction, protein transport, and, crucially, protein geranylgeranylation (including its positive regulation), which is a lipid modification essential for Rab membrane targeting and function. Activation of GTPase activity aligns with Rab cycling between active/inactive states. While some fish-specific terms appear, the core signal centers on Rab-mediated membrane trafficking and related post-translational modification, suggesting the cluster represents Rab GTPase\u2013related processes.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0050935","count":1},{"id":"GO:0032482","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0018344","count":1}]},{"hash":"655112054884778520","title":"Protein quality control and ER targeting","description":"These terms converge on maintaining protein homeostasis: folding, chaperone activity, ER stress response, and targeting of proteins to membranes. A few terms (iron-sulfur cluster assembly, DNA replication) appear ancillary or broad annotations, but the dominant theme is protein quality control and trafficking.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034620","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0006260","count":1},{"id":"GO:1903382","count":1},{"id":"GO:0070389","count":1}]},{"hash":"1087405967576150292","title":"Nuclear RNA Processing and DNA Metabolism","description":"This cluster centers on nuclear RNA quality control and processing (NMD, mRNA surveillance, nuclear mRNA decay, polyA-dependent decay, ribosome biogenesis) with a broader set of DNA-centric processes (DNA replication, primer synthesis, transcription-coupled repair, recombination) and related nuclear transport. The mixed GO terms suggest proteins that partake in both RNA metabolism in the nucleus and DNA maintenance activities, with some links to RNA handling in cytoplasmic stress granules. Confidence: Medium","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0017038","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0000184","count":3},{"id":"GO:1903608","count":3},{"id":"GO:0071042","count":3}]},{"hash":"1705251162640610721","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006407","count":1},{"id":"GO:0000461","count":1},{"id":"GO:0000028","count":1}]},{"hash":"1230475622460684029","title":"Methylation and RNA Modification","description":"The cluster\u2019s terms are dominated by RNA methylation (rRNA methylation, tRNA wobble uridine modification) and protein methylation, with cobalamin biosynthesis also involving methyltransferase activities. While stress and xenobiotic response terms appear, they are ancillary to the core methylation-related functions, making this a reasonable, representative label.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0006972","count":1},{"id":"GO:0006479","count":1},{"id":"GO:0046690","count":1},{"id":"GO:0002098","count":1}]},{"hash":"1745697550857416395","title":"Microtubule-based transport and organization","description":"Top terms cluster around microtubule dynamics, motor-driven transport, and centrosome/spindle organization, including plus-end sliding, nuclear migration along microtubules, and dendritic transport. These reflect a cohesive theme of microtubule-based movement and cellular architecture, with some tissue-specific structural hints. Thus label: Microtubule-based transport and organization.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":3},{"id":"GO:0007100","count":3},{"id":"GO:0032886","count":3},{"id":"GO:0031535","count":3},{"id":"GO:0030473","count":3}]},{"hash":"1776686783984716002","title":"Mitochondrial tRNA charging and translation","description":"These proteins are enriched for mitochondrial-specific tRNA aminoacylation activities (for asparagine, lysine, and aspartate) and translation, plus tRNA wobble modification, pointing to a coherent mitochondrially focused translation machinery. Obsolete lysine modification terms are historical references and do not change the core theme. Overall, the cluster aligns with mitochondrial protein synthesis processes.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0070145","count":2},{"id":"GO:0072581","count":2},{"id":"GO:0070154","count":2},{"id":"GO:0071915","count":2}]},{"hash":"935654257594449869","title":"Cellular stress response and apoptosis","description":"The top GO terms point to responses to antibiotics and xenobiotics, a cellular response to cAMP, and an apoptotic process. Together they suggest a cluster of proteins involved in cellular stress signaling leading to programmed cell death, with additional hints of xenobiotic/chemical response. Some terms are less cohesive (e.g., DNA catabolic process, hemolysis in another organism), but the dominant theme centers on stress response and apoptosis.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0014912","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0071320","count":1},{"id":"GO:0044179","count":1}]},{"hash":"276073711732214850","title":"Nuclear RNA processing and spliceosome assembly","description":"Based on the GO terms, this cluster concentrates on nuclear RNA metabolism and splicing: tRNA processing, mRNA splicing via spliceosome, snRNP/spliceosome assembly, mRNA decapping/deadenylation, and rRNA maturation, with nucleus import and histone mRNA metabolism as related processes. These together suggest a cohesive group of proteins involved in RNA maturation and spliceosome function in the nucleus; plant stress-response terms appear ancillary and not central to the core function.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008334","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0009737","count":2},{"id":"GO:0045292","count":2}]},{"hash":"1565466471106648429","title":"Nuclear gene expression and ribosome biogenesis","description":"The proteins aggregate around nuclear processes like mRNA splicing, rRNA transcription, ribosome biogenesis and export, translation, and transcriptional regulation, indicating a coordinated role in gene expression and ribosome assembly. This combination supports a cohesive theme of nuclear gene expression and ribosome biogenesis. ","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0032298","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0006412","count":1}]},{"hash":"540798205253592241","title":"Ribosome Biogenesis and rRNA Processing","description":"The top GO terms cluster tightly around translation and ribosome assembly\u2014cytoplasmic translation, maturation of SSU/LSU rRNA, ribosome biogenesis, and ribosomal large subunit assembly\u2014indicating the proteins are involved in ribosome production and rRNA maturation. A few terms like response to antibiotic or IL-4 are peripheral and do not override the core ribosome-related theme.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0002181","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0042254","count":1}]},{"hash":"316932676845759994","title":"Unknown","description":"There are no GO terms provided to link these proteins into a common function, so a meaningful label cannot be derived. The available network metrics alone do not reveal a clear shared function.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[]},{"hash":"664536540957987202","title":"RNA Processing and Spliceosome Assembly","description":"The cluster is dominated by GO terms related to RNA metabolism and splicing, including mRNA splicing via the spliceosome, spliceosomal snRNP assembly, deadenylation-dependent decapping of mRNA, tRNA processing, histone mRNA metabolism, and rRNA maturation, suggesting a cohesive role in nuclear RNA processing; ABA and water-deprivation responses and cell-cycle regulation appear ancillary.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008334","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0070317","count":1},{"id":"GO:0009737","count":1},{"id":"GO:0045292","count":1}]},{"hash":"1002192502686977268","title":"Unknown","description":"The linked GO terms are a scattered mix, including osmoregulation (osmotic stress response, water homeostasis, ion transport) alongside development and extracellular matrix processes, with no single cohesive function emerging. Therefore, a clear, specific label is not evident.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071470","count":1},{"id":"GO:0034220","count":1},{"id":"GO:0009992","count":1},{"id":"GO:0048015","count":1},{"id":"GO:1904888","count":1}]},{"hash":"762680468172572939","title":"Mycobacterial cell envelope biosynthesis","description":"This cluster centers on biosynthesis of cell wall and capsule components typical of mycobacteria, including capsule polysaccharide biosynthesis, mycolate layer assembly, and arabinogalactan-related intermediates (e.g., undecaprenyl phosphate\u2013linked arabinose). The recurring themes of UDP-sugar metabolism and various polysaccharide biosynthetic processes reinforce a cohesive function in building the mycobacterial cell envelope.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0006011","count":2},{"id":"GO:0036108","count":1},{"id":"GO:0045227","count":1},{"id":"GO:0071769","count":1}]},{"hash":"1909769834489467562","title":"Nuclear RNA processing and spliceosome assembly","description":"The cluster is dominated by RNA processing activities in the nucleus: mRNA splicing via the spliceosome, spliceosomal snRNP assembly, mRNA decapping, and rRNA/tRNA maturation, plus import into the nucleus. These terms point to a cohesive group of factors involved in RNA maturation and spliceosome assembly, with additional but less central signals for nuclear localization and broader regulatory responses. ","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0008334","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0070317","count":1}]},{"hash":"663926581567971885","title":"tRNA aminoacylation and translation","description":"This cluster is driven by translation- and tRNA-related processes: multiple GO terms for aminoacylation of tRNAs (prolyl-, glutaminyl-, glutamyl-) and tRNA modification/wobble uridine modification, plus a general translation term. A few terms touch on diphthamide formation on histidine and some cell-cycle or stress-related pathways, but the dominant signal ties to tRNA charging and protein synthesis.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0006433","count":1},{"id":"GO:0006425","count":1},{"id":"GO:0006400","count":1},{"id":"GO:0006424","count":1}]},{"hash":"962859436139690833","title":"Embryonic skeletal and neural development","description":"The top GO terms cluster around embryonic morphogenesis and differentiation of skeletal and neural tissues (cranial skeleton morphogenesis, osteoblast development, spinal cord motor neuron fate specification, oculomotor nerve formation, interneuron fate), with an additional kidney morphogenesis term, suggesting a broad embryonic organogenesis theme.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0021520","count":2},{"id":"GO:0021623","count":2},{"id":"GO:0035623","count":2},{"id":"GO:0060580","count":2}]},{"hash":"2243561026937269030","title":"Post-transcriptional mRNA processing and translation control","description":"The top GO terms cluster around mRNA maturation, stability, processing, poly(A) tail regulation, and translation initiation/miRNA-mediated silencing, suggesting proteins in this cluster regulate post-transcriptional mRNA fate and translation.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016556","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0010610","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0034462","count":1}]},{"hash":"1317589857494623581","title":"Embryonic Organ Morphogenesis","description":"The Top Terms are dominated by broad developmental and morphogenesis processes across multiple organs (somitogenesis, cranial skeletal system morphogenesis, heart outflow tract morphogenesis, brain region development, etc.), with no single shared function, so this label best reflects a general theme of embryonic development rather than a specific pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002361","count":1},{"id":"GO:0061374","count":1},{"id":"GO:0035881","count":1},{"id":"GO:0003146","count":1},{"id":"GO:0001756","count":1}]},{"hash":"1518083980599131842","title":"Mitochondrial Protein Folding and Import","description":"The strongest terms point to chaperone-mediated protein complex assembly and import into the mitochondrial intermembrane space, supported by protein refolding. This suggests the cluster centers on mitochondrial protein quality control and translocation. The other terms (cell division, telomere maintenance, virion assembly, ischemia response, TNF production) are less cohesive with this core theme, likely reflecting broader or secondary annotations.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051131","count":2},{"id":"GO:0045041","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0042026","count":1},{"id":"GO:0032212","count":1}]},{"hash":"28517799922860221","title":"Embryonic Development and Tissue Growth","description":"This cluster centers on broad developmental and organogenesis processes across multiple tissues (seminiferous tubule, spinal cord, skin, embryonic organs) and includes notes on growth and cell proliferation, with supporting signals of chromatin organization and mitotic processes, suggesting a cohesive theme of developmental growth and tissue differentiation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072520","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0007064","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0008283","count":3}]},{"hash":"1542310731321308908","title":"Unknown","description":"These proteins show a highly diverse set of GO terms (protein refolding, telomere maintenance via telomerase, virion assembly, pore complex assembly, scaRNA localization to Cajal bodies, response to ischemia, TNF production) with several obsolete annotations, offering no clear shared function or pathway. Thus, there isn\u2019t a coherent theme to name the cluster beyond Unknown.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042026","count":1},{"id":"GO:0032212","count":1},{"id":"GO:0051973","count":1},{"id":"GO:0052212","count":1},{"id":"GO:0002931","count":1}]},{"hash":"728222419768240068","title":"Unknown","description":"The GO terms span muscle development (skeletal muscle fiber development, mesoderm development, potential hypertrophy signaling) but also include neuronal calcium signaling, DNA replication, meiotic processes, histone dephosphorylation, and plant brassinosteroid signaling, showing no coherent, single-function theme across the cluster. Given this mix, there isn\u2019t a clear common function tying all proteins together. ","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0099566","count":1},{"id":"GO:0098609","count":1},{"id":"GO:1903244","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0016576","count":1}]},{"hash":"789903168143014896","title":"Lipid catabolism and signaling","description":"The terms show a focus on lipid-related catabolic processes (phosphatidylserine, triglyceride, monoacylglycerol catabolism) and lipid-based signaling (regulation of endocannabinoid signaling). While there are some plant- and other metabolite-related terms, the strongest recurring theme across the frequent terms is lipid metabolism and lipid signaling, supporting this label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000124","count":2},{"id":"GO:0006660","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0052651","count":2},{"id":"GO:1901601","count":1}]},{"hash":"1250199135680637874","title":"Osmotic stress-responsive transcription regulation","description":"The top terms show both transcription machinery activity (initiation-coupled chromatin remodeling and Pol II elongation) and osmotic/osmoregulatory processes (cellular response to osmotic stress, intracellular water homeostasis, ion transport), suggesting a module where transcriptional regulation is linked to osmotic stress response and water/ion balance.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048096","count":1},{"id":"GO:0006368","count":1},{"id":"GO:0071470","count":1},{"id":"GO:0034220","count":1},{"id":"GO:0009992","count":1}]},{"hash":"1710414702416674144","title":"Neuronal development and metabolism","description":"The terms point to neural development (pyramidal neuron development, cerebellar cortex development, tangential migration to the olfactory bulb) and general metabolic processes (glycolysis, glucose metabolism, branched-chain amino acid catabolism, glyoxylate metabolism), suggesting proteins involved in brain development with associated energy metabolism. Some terms are obsolete, but the overarching theme ties neuronal maturation to metabolic activity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022028","count":1},{"id":"GO:0046487","count":1},{"id":"GO:0010510","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0006096","count":1}]},{"hash":"2170579418215098158","title":"Unknown","description":"The Top Terms indicate a mix of developmental (pituitary gland and cerebral cortex development, stem cell proliferation) and metabolic processes (amino acid and thiamine biosynthesis, catabolism) with no coherent common function or interaction among the proteins.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":2},{"id":"GO:0042208","count":1},{"id":"GO:0009228","count":1},{"id":"GO:0021987","count":1},{"id":"GO:0010731","count":1}]},{"hash":"1718716747263336835","title":"Unknown","description":"The GO terms are spread across brain development, apoptosis and stress responses, cell cycle regulation, protein trafficking, and keratinization, with no clear, shared function binding the cluster. This heterogeneity makes a cohesive, specific label inappropriate.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021987","count":1},{"id":"GO:0006713","count":1},{"id":"GO:0008630","count":1},{"id":"GO:0000079","count":1},{"id":"GO:1900740","count":1}]},{"hash":"802069911353161766","title":"RNA transcription and ribosome biogenesis","description":"Most of the top GO terms point to transcriptional processes (RNA polymerase I, II, and III\u2013mediated transcription, RNA-templated transcription) and ribosome biogenesis, suggesting a role in nucleic acid metabolism and assembly of the translation machinery. The inclusion of DNA repair and various carbohydrate metabolism terms appears as potential annotations or cross-talk with basic cellular metabolism, but the dominant signal remains transcription and ribosome production.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006098","count":1},{"id":"GO:0019310","count":1},{"id":"GO:0019854","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0042732","count":1}]},{"hash":"1431114837989390270","title":"Ribosome Biogenesis and RNA Processing","description":"This cluster is marked by GO terms tied to ribosome biogenesis and RNA maturation, including rRNA base methylation, tRNA wobble base methylation, maturation of LSU rRNA, and assembly of large subunit preribosomes/cytosolic ribosome assembly, indicating a shared role in ribosome production and RNA processing, with possible translation-related regulation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070475","count":1},{"id":"GO:0002127","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0000463","count":1}]},{"hash":"1713356860993483494","title":"Post-transcriptional mRNA processing and translation regulation","description":"This cluster centers on post-transcriptional control of gene expression: translation initiation and reinitiation, mRNA processing and polyadenylation, and regulation of mRNA stability and translation by miRNAs. It also includes components involved in small-subunit processome assembly, highlighting ribosome biogenesis ties. A few terms (e.g., blastocyst formation) appear less directly related and may be incidental. ","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0016556","count":1},{"id":"GO:0010610","count":1}]},{"hash":"2230035566523791088","title":"RNA Processing and Translation Regulation","description":"The cluster centers on post-transcriptional gene expression control, with GO terms spanning mRNA modification, stability, poly(A) tail dynamics, splicing regulation, small-subunit preinitiation complex formation, and miRNA-mediated silencing of translation. This points to a cohesive role in RNA maturation and regulation of translation, with a minor developmental annotation (blastocyst formation) that may be context-specific or incidental.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016556","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0010610","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0034462","count":1}]},{"hash":"203703361642587570","title":"Unknown","description":"The GO terms across the three proteins cover DNA repair, vesicle trafficking, transcription initiation, metabolism, and replication, with no single cohesive function dominating. Only UV-damage excision repair appears repeatedly, while other terms point to disparate cellular processes, providing no clear shared theme for a concise label.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070914","count":2},{"id":"GO:0044694","count":1},{"id":"GO:0061166","count":1},{"id":"GO:0045899","count":1},{"id":"GO:0046034","count":1}]},{"hash":"1759626069745370843","title":"Unknown","description":"The top GO terms are highly diverse, including nonfunctional rRNA decay, heat acclimation, membrane trafficking, ATP metabolism, transcription initiation, DNA replication, and even photosynthesis. There is no single dominant function or coherent pathway linking these terms, suggesting the cluster may be a mix of unrelated processes or an artifact rather than a distinct biological unit.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070651","count":2},{"id":"GO:0070370","count":2},{"id":"GO:0044694","count":1},{"id":"GO:0061166","count":1},{"id":"GO:0045899","count":1}]},{"hash":"53959765395307649","title":"Choline and ethanolamine phospholipid biosynthesis","description":"The cluster\u2019s top GO terms cluster around choline metabolism, the CDP-choline pathway, ethanolamine metabolism, and phosphatidylethanolamine biosynthesis, all indicating involvement in glycerophospholipid synthesis. Some terms are obsolete or peripheral (e.g., methionine salvage), but they do not obscure the lipid biosynthesis focus. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019509","count":1},{"id":"GO:0019695","count":1},{"id":"GO:0009088","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0016310","count":1}]},{"hash":"890179248401674226","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by translation and ribosome-related processes, including translation (GO:0006412), maturation of SSU-rRNA (GO:0000462), large subunit biogenesis (GO:0042273), large subunit assembly (GO:0000027), and export from the nucleus (GO:0000055). This pattern points to proteins involved in ribosome assembly/biogenesis and the translation machinery, with an incidental mention of antineoplastic agent response. Overall, the cluster appears to represent ribosome production and function.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000462","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0000027","count":1}]},{"hash":"2279476446503615621","title":"Pyrimidine Nucleotide Metabolism","description":"The cluster is defined by GO terms tied to biosynthesis and catabolism of pyrimidine nucleotides (dUMP, dUTP, dITP) and pyrimidine ribonucleotides, indicating a cohesive role in pyrimidine nucleotide metabolism and turnover.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006226","count":1},{"id":"GO:0006229","count":1},{"id":"GO:0046081","count":1},{"id":"GO:0009220","count":1},{"id":"GO:0035863","count":1}]},{"hash":"1280410125494410976","title":"Ribosome Biogenesis and Translation","description":"The top GO terms cluster around ribosome biogenesis (including small subunit biogenesis and rRNA processing), cytoplasmic translation, and tRNA modification, with also a term for regulation of translation initiation. These point to a core ribosome/translation machinery theme, with minor association to cell division that may reflect overall growth coordination.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0006412","count":1},{"id":"GO:1901194","count":1},{"id":"GO:0090529","count":1},{"id":"GO:0002181","count":1}]},{"hash":"2202850445419717807","title":"Translation Initiation Complexes","description":"This cluster is defined by GO terms centered on translation initiation and ribosome assembly (translation, formation of translation preinitiation and cytoplasmic initiation complexes, translational initiation, cytosolic ribosome assembly), suggesting proteins involved in protein synthesis initiation. Some germ cell- or fertilization-related terms appear but do not drive the core theme. High confidence that the label reflects the cluster\u2019s function.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0002176","count":1},{"id":"GO:0045947","count":1},{"id":"GO:0001732","count":1}]},{"hash":"801249614309544942","title":"Unknown","description":"The top terms span diverse processes\u2014from development (lung morphogenesis) and signaling (KIT pathway) to neural processes (axonogenesis regulation, long-term potentiation), cell fate (apoptosis), basic replication (DNA replication), and antiviral responses. There is no clear, cohesive theme tying these GO terms into a single function or pathway for this small cluster, so a specific label isn\u2019t justifiable. None","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060425","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0038109","count":2},{"id":"GO:0050771","count":2},{"id":"GO:0032801","count":2}]},{"hash":"1926633421302389627","title":"Nuclear transcription, RNA processing, and DNA repair","description":"This cluster centers on nuclear processes: transcription initiation and promoter engagement, RNA metabolism and decay (including NMD and polyadenylation-dependent decay), and transcription-coupled DNA repair with UV protection signals. The presence of protein import into the nucleus and related stress responses (hypoxia) further supports a cohesive nuclear RNA/DNA metabolic module. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017038","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0001113","count":2},{"id":"GO:0000184","count":2},{"id":"GO:1903608","count":2}]},{"hash":"1612566701435311373","title":"Unknown","description":"The terms span chromatin regulation (rDNA heterochromatin formation, histone methylation), p53-mediated apoptotic signaling, cell cycle regulation, xenobiotic and tellurium ion responses, and a metabolism term, but they do not converge on a single clear function for the cluster.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046690","count":1},{"id":"GO:0002098","count":1},{"id":"GO:0030961","count":1},{"id":"GO:0072332","count":1},{"id":"GO:0000183","count":1}]},{"hash":"818485964496175498","title":"Unknown","description":"This cluster has no shared GO terms listed and only a small, non-transitive connection (two edges, no triangles) among three proteins, providing no clear functional theme to base a label on.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"625891564828928677","title":"mRNA Processing and Translational Control","description":"The terms center on mRNA maturation and stability (modification, poly(A) tail regulation, stabilization, splicing regulation) and on control of translation (preinitiation complex formation, miRNA-mediated silencing), including components of the small-subunit processome. This cohesion suggests a cluster dedicated to RNA processing and how mRNA is translated or silenced, rather than a single enzymatic or signaling activity.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016556","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0010610","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0034462","count":1}]},{"hash":"29929114685607214","title":"DNA repair and telomere maintenance","description":"This cluster centers on genome stability: several GO terms point to DNA repair mechanisms (non-photoreactive DNA repair) and telomere biology (telomeric DNA-containing double minutes, negative regulation of protection at telomeres), with UV protection as a general DNA damage response. The combination suggests a coherent theme of maintaining genomic integrity, with links to aging and development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010259","count":1},{"id":"GO:0061819","count":1},{"id":"GO:0045190","count":1},{"id":"GO:0010213","count":1},{"id":"GO:1904431","count":1}]},{"hash":"1566371921652752973","title":"mRNA processing and translation control","description":"The cluster centers on post-transcriptional regulation: mRNA modification, formation of the translation preinitiation complex, mRNA stability and poly(A) tail regulation, miRNA-mediated translational repression, and splicing control. Together these indicate a group of proteins involved in mRNA maturation and control of translation. An outlier term related to blastocyst formation may reflect developmental contexts for these factors but does not change the core RNA-processing theme.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016556","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0010610","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0034462","count":1}]},{"hash":"947744269271415804","title":"Organelle protein import and targeting","description":"This set centers on proteins imported into or targeted to organelles\u2014mitochondria (inner membrane, matrix), chloroplasts (stroma), and vacuoles\u2014highlighting a common theme of organelle protein trafficking. The other terms (vacuole organization, ion transport, ATP synthesis) align with organelle function, reinforcing the trafficking/assembly context rather than a single metabolic pathway.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":1},{"id":"GO:0045039","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0000002","count":1},{"id":"GO:0045037","count":1}]},{"hash":"329024298024405873","title":"Unknown","description":"The GO terms are highly diverse, spanning cardiac muscle development, plant reproductive processes, behavior regulation, amyloid clearance, and transcription, with no clear common function or pathway tying them together. This mixture suggests no single representative function for the cluster, so an Unknown label is most appropriate.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055005","count":1},{"id":"GO:0002634","count":1},{"id":"GO:0060867","count":1},{"id":"GO:0048455","count":1},{"id":"GO:0010076","count":1}]}]