{"hash":"1382932193673214963","title":"RNA Processing and Translational Initiation Regulation","description":"These proteins cluster around translation initiation, including formation of the preinitiation complex, IRES-dependent and reinitiation events, and regulation of translational initiation, suggesting a module focused on controlling protein synthesis at initiation. The presence of regulatory ncRNA-mediated gene silencing and spliceosome-associated regulation of splicing hints at broader RNA-processing roles that modulate translation. A few terms (e.g., obsolete polyadenylation, transcription-coupled repair) are peripheral to the core theme. Overall, the cluster appears to couple RNA processing with initiation-level translation control.","confidence":"Medium","size":16,"edges":67,"triangles":135,"max_degree":14,"top_function":null,"members":[{"accession":"NP_011095.1","go_terms":["GO:1990180","GO:0006378","GO:0001680","GO:0042245"]},{"accession":"NP_011368.3","go_terms":["GO:0002181","GO:0046677"]},{"accession":"NP_013067.1","go_terms":[]},{"accession":"NP_014703.1","go_terms":[]},{"accession":"NP_010142.2","go_terms":["GO:0034080","GO:0090234","GO:0051382","GO:1903099","GO:0000086","GO:0051101","GO:2000059","GO:0071459"]},{"accession":"NP_010720.3","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"NP_011666.1","go_terms":["GO:0031425","GO:0016554","GO:0080156","GO:0000961","GO:1905639","GO:0009793","GO:1900865","GO:0042793","GO:0031426","GO:0090617"]},{"accession":"NP_012617.1","go_terms":["GO:0032436","GO:0001701","GO:0048142","GO:0043248","GO:0007127","GO:0075525","GO:0000122","GO:0008283","GO:0002188","GO:0035914","GO:1902416","GO:0071033","GO:0006283","GO:0030182","GO:0070196","GO:0000338","GO:0075522","GO:0006446","GO:0034260","GO:0070321","GO:0010972","GO:0048863","GO:0001732","GO:0001731","GO:0048140","GO:0036099","GO:0090054","GO:0090052","GO:0000715","GO:0000973","GO:0006511"]},{"accession":"NP_013567.3","go_terms":["GO:0006343"]},{"accession":"NP_013957.1","go_terms":["GO:2000032","GO:0090506","GO:0031581","GO:0000028","GO:0034198","GO:0006407"]},{"accession":"NP_014017.1","go_terms":["GO:0000184","GO:0071042","GO:0043629","GO:0034476","GO:0071049","GO:0071051","GO:0000472","GO:0009432","GO:1990120","GO:0048026","GO:0014070","GO:0042273","GO:0016973","GO:0070417","GO:0042255","GO:0000388","GO:0035640","GO:0006265","GO:0006260","GO:1902775","GO:1904570","GO:1903241","GO:0010501","GO:1904574","GO:0006269","GO:0034475","GO:0071031","GO:0048701","GO:0006283","GO:0071035","GO:0031124","GO:0071038","GO:0072715","GO:1990416","GO:0000462","GO:0008306","GO:0000464","GO:0018144","GO:0000466","GO:0000467","GO:1903608","GO:0000378","GO:0006310","GO:1902626","GO:0000393","GO:0000390","GO:0090394","GO:0006268","GO:0000716","GO:0000398","GO:0000463","GO:0045944","GO:0016441","GO:1990417","GO:0000480","GO:0001178","GO:0042766","GO:0006306","GO:0006301","GO:0043044","GO:0006605","GO:0070870","GO:0071441","GO:0060303","GO:0006363","GO:0006369","GO:1900050","GO:0019079","GO:0017038","GO:0071894","GO:2000616","GO:0031047","GO:0016584","GO:0006311","GO:0045003","GO:0001113","GO:0048568","GO:0001111","GO:0009650","GO:0001666","GO:0035315","GO:0033683","GO:0006367","GO:0060543","GO:0009307","GO:0006289","GO:0039530","GO:0000717","GO:0000027"]},{"accession":"NP_014383.1","go_terms":[]},{"accession":"NP_013251.1","go_terms":["GO:0000723","GO:0043066","GO:0043558","GO:0006414","GO:0031929"]},{"accession":"NP_010104.1","go_terms":["GO:0072755","GO:1990253","GO:1990138","GO:0097201","GO:0071494","GO:0070301","GO:0031953","GO:0071264","GO:0042149","GO:0031333","GO:0071468","GO:0060733"]},{"accession":"NP_116591.1","go_terms":["GO:0006343"]},{"accession":"NP_015239.1","go_terms":["GO:0032920","GO:0019491","GO:0010125","GO:0046208","GO:0001525","GO:0071962","GO:0006348","GO:0006526","GO:0017196","GO:0061606","GO:0017198","GO:0030187","GO:0032919","GO:0032918","GO:0043967","GO:0060358","GO:0009447","GO:0045150","GO:0006041","GO:0006044","GO:2000025","GO:0018003","GO:0018002","GO:0006777","GO:0009234","GO:0046677","GO:0042426","GO:0009107","GO:0009102","GO:0030488","GO:0006782","GO:0018339","GO:0070475","GO:0009249","GO:0009228","GO:0008616","GO:0018189","GO:0019475","GO:0010928","GO:0048789","GO:2000289","GO:0009294","GO:0090708","GO:0002098"]}],"graph":[["NP_012617.1","NP_010104.1",0.619],["NP_012617.1","NP_011368.3",0.773],["NP_012617.1","NP_011666.1",0.537],["NP_012617.1","NP_116591.1",0.502],["NP_012617.1","NP_014703.1",0.674],["NP_012617.1","NP_013957.1",0.682],["NP_012617.1","NP_014017.1",0.701],["NP_012617.1","NP_014383.1",0.593],["NP_012617.1","NP_013067.1",0.665],["NP_012617.1","NP_013251.1",0.531],["NP_012617.1","NP_013567.3",0.616],["NP_011666.1","NP_010104.1",0.58],["NP_011666.1","NP_116591.1",0.57],["NP_011666.1","NP_014703.1",0.585],["NP_011666.1","NP_013957.1",0.623],["NP_011666.1","NP_014017.1",0.584],["NP_011666.1","NP_013567.3",0.571],["NP_011666.1","NP_013067.1",0.547],["NP_011666.1","NP_011095.1",0.623],["NP_011666.1","NP_011368.3",0.703],["NP_010142.2","NP_011368.3",0.607],["NP_013957.1","NP_011095.1",0.686],["NP_013957.1","NP_011368.3",0.76],["NP_013957.1","NP_013067.1",0.519],["NP_013957.1","NP_013251.1",0.65],["NP_013957.1","NP_013567.3",0.641],["NP_013957.1","NP_014017.1",0.68],["NP_013957.1","NP_014383.1",0.705],["NP_013957.1","NP_014703.1",0.638],["NP_013067.1","NP_010104.1",0.548],["NP_013067.1","NP_011368.3",0.769],["NP_013067.1","NP_116591.1",0.69],["NP_013067.1","NP_014703.1",0.686],["NP_013067.1","NP_014383.1",0.603],["NP_013067.1","NP_013567.3",0.729],["NP_010104.1","NP_015239.1",0.623],["NP_010104.1","NP_116591.1",0.649],["NP_010104.1","NP_014703.1",0.5],["NP_010104.1","NP_014017.1",0.668],["NP_010104.1","NP_013251.1",0.532],["NP_010104.1","NP_013567.3",0.516],["NP_010104.1","NP_011095.1",0.566],["NP_010104.1","NP_011368.3",0.615],["NP_011368.3","NP_010720.3",0.579],["NP_011368.3","NP_116591.1",0.822],["NP_011368.3","NP_014703.1",0.713],["NP_011368.3","NP_014017.1",0.722],["NP_011368.3","NP_014383.1",0.737],["NP_011368.3","NP_013251.1",0.658],["NP_011368.3","NP_013567.3",0.778],["NP_011368.3","NP_011095.1",0.654],["NP_014703.1","NP_013567.3",0.724],["NP_014703.1","NP_014017.1",0.617],["NP_014703.1","NP_116591.1",0.589],["NP_011095.1","NP_015239.1",0.535],["NP_011095.1","NP_014017.1",0.736],["NP_011095.1","NP_013567.3",0.689],["NP_014017.1","NP_010720.3",0.528],["NP_014017.1","NP_013567.3",0.695],["NP_014017.1","NP_015239.1",0.517],["NP_015239.1","NP_013567.3",0.716],["NP_015239.1","NP_014383.1",0.503],["NP_015239.1","NP_116591.1",0.501],["NP_013251.1","NP_010720.3",0.567],["NP_013251.1","NP_013567.3",0.799],["NP_014383.1","NP_013567.3",0.763],["NP_013567.3","NP_116591.1",0.58]],"all_go_terms":{"GO:1990180":1,"GO:0006378":2,"GO:0042245":1,"GO:0001680":1,"GO:0046677":2,"GO:0002181":1,"GO:0051101":1,"GO:0071459":1,"GO:0051382":1,"GO:0090234":1,"GO:0034080":1,"GO:1903099":1,"GO:2000059":1,"GO:0000086":1,"GO:1903586":1,"GO:1905663":1,"GO:1900363":1,"GO:1901407":1,"GO:0010610":1,"GO:0048255":1,"GO:0000381":1,"GO:0035278":1,"GO:0001731":2,"GO:0031047":2,"GO:0097010":1,"GO:0006376":1,"GO:0016556":1,"GO:0002188":2,"GO:0048026":2,"GO:0075522":2,"GO:0006406":1,"GO:0006446":2,"GO:0048025":1,"GO:0001825":1,"GO:0045292":1,"GO:0034462":1,"GO:0060211":1,"GO:0075525":2,"GO:0000380":1,"GO:1902625":1,"GO:1905639":1,"GO:0016554":1,"GO:0009793":1,"GO:1900865":1,"GO:0031425":1,"GO:0080156":1,"GO:0042793":1,"GO:0000961":1,"GO:0031426":1,"GO:0090617":1,"GO:0000122":1,"GO:0007127":1,"GO:0001701":1,"GO:0035914":1,"GO:0048140":1,"GO:0071033":1,"GO:0010972":1,"GO:0090054":1,"GO:0000715":1,"GO:0043248":1,"GO:0001732":1,"GO:0034260":1,"GO:0030182":1,"GO:1902416":1,"GO:0070196":1,"GO:0090052":1,"GO:0036099":1,"GO:0008283":1,"GO:0006283":2,"GO:0032436":1,"GO:0048863":1,"GO:0000338":1,"GO:0070321":1,"GO:0048142":1,"GO:0006511":1,"GO:0000973":1,"GO:0006343":2,"GO:2000032":1,"GO:0031581":1,"GO:0000028":1,"GO:0006407":1,"GO:0034198":1,"GO:0090506":1,"GO:0017038":1,"GO:0000393":1,"GO:0060303":1,"GO:0001113":1,"GO:0006605":1,"GO:0071894":1,"GO:0014070":1,"GO:0000472":1,"GO:0000388":1,"GO:0031124":1,"GO:0071031":1,"GO:0016584":1,"GO:0000390":1,"GO:0006260":1,"GO:0071042":1,"GO:0000467":1,"GO:0016441":1,"GO:0006301":1,"GO:0048701":1,"GO:0009432":1,"GO:2000616":1,"GO:0006289":1,"GO:0070417":1,"GO:1900050":1,"GO:0006269":1,"GO:1904570":1,"GO:0035315":1,"GO:0070870":1,"GO:0009650":1,"GO:0001666":1,"GO:1902775":1,"GO:1903608":1,"GO:0009307":1,"GO:0071049":1,"GO:0006306":1,"GO:0001178":1,"GO:0039530":1,"GO:0006369":1,"GO:0034476":1,"GO:0072715":1,"GO:0006363":1,"GO:1990120":1,"GO:0000184":1,"GO:0006311":1,"GO:0008306":1,"GO:0000463":1,"GO:1904574":1,"GO:1990417":1,"GO:0000717":1,"GO:0016973":1,"GO:0010501":1,"GO:0000462":1,"GO:0006265":1,"GO:1990416":1,"GO:0042273":1,"GO:1903241":1,"GO:0006310":1,"GO:0043044":1,"GO:0033683":1,"GO:0000716":1,"GO:0071035":1,"GO:0019079":1,"GO:0034475":1,"GO:0060543":1,"GO:0000027":1,"GO:0045003":1,"GO:0000378":1,"GO:0043629":1,"GO:0000464":1,"GO:0045944":1,"GO:0071441":1,"GO:0042766":1,"GO:1902626":1,"GO:0000398":1,"GO:0001111":1,"GO:0000480":1,"GO:0000466":1,"GO:0018144":1,"GO:0090394":1,"GO:0035640":1,"GO:0006367":1,"GO:0042255":1,"GO:0071051":1,"GO:0006268":1,"GO:0048568":1,"GO:0071038":1,"GO:0000723":1,"GO:0043558":1,"GO:0031929":1,"GO:0043066":1,"GO:0006414":1,"GO:0072755":1,"GO:0071468":1,"GO:0060733":1,"GO:1990138":1,"GO:0071494":1,"GO:0097201":1,"GO:0070301":1,"GO:0071264":1,"GO:0031333":1,"GO:0042149":1,"GO:0031953":1,"GO:1990253":1,"GO:0032920":1,"GO:0006044":1,"GO:0060358":1,"GO:0017196":1,"GO:0030488":1,"GO:0006526":1,"GO:0032919":1,"GO:0048789":1,"GO:0009102":1,"GO:0071962":1,"GO:0001525":1,"GO:2000289":1,"GO:0070475":1,"GO:0061606":1,"GO:0018189":1,"GO:0010928":1,"GO:0010125":1,"GO:0006041":1,"GO:0009294":1,"GO:0042426":1,"GO:0017198":1,"GO:0030187":1,"GO:0002098":1,"GO:0009249":1,"GO:0043967":1,"GO:0006348":1,"GO:0032918":1,"GO:0045150":1,"GO:0090708":1,"GO:0019475":1,"GO:0006777":1,"GO:0009234":1,"GO:0006782":1,"GO:0009447":1,"GO:0018003":1,"GO:0046208":1,"GO:0008616":1,"GO:0018339":1,"GO:0009107":1,"GO:0018002":1,"GO:0009228":1,"GO:2000025":1,"GO:0019491":1},"recipe_readded":[]}