{"hash":"866662667084993746","title":"Aminoacyl-tRNA Synthetases in Translation Signaling","description":"The cluster is dominated by GO terms for valyl-, leucyl-, methionyl-, and isoleucyl-tRNA aminoacylation and translation, pointing to a core set of aminoacyl-tRNA synthetases driving protein synthesis. The additional terms for positive regulation of angiogenesis, MAPK cascade, endothelial cell proliferation, and PI3K/AKT signaling reflect known noncanonical roles of tRNA synthetases in signaling pathways that influence angiogenesis and cell proliferation, suggesting these proteins participate in translation-related functions with signaling outputs. Overall, this cluster centers on aminoacyl-tRNA synthetases with translational roles and allied signaling activities.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"members":[{"accession":"XP_013757798.1","go_terms":["GO:0006450","GO:0006431","GO:0006438","GO:0006428","GO:0006429","GO:0006412"]},{"accession":"XP_013757218.1","go_terms":[]},{"accession":"XP_013758844.1","go_terms":["GO:0045766","GO:0043410","GO:0001938","GO:0014068","GO:0051897"]}],"graph":[["XP_013757218.1","XP_013757798.1",0.583],["XP_013758844.1","XP_013757798.1",0.905]],"all_go_terms":{"GO:0006438":1,"GO:0006429":1,"GO:0006431":1,"GO:0006428":1,"GO:0006450":1,"GO:0006412":1,"GO:0045766":1,"GO:0043410":1,"GO:0001938":1,"GO:0051897":1,"GO:0014068":1},"recipe_readded":[]}