[{"hash":"767531973325701658","title":"Bacterial DNA metabolism and cell wall biosynthesis","description":"The cluster shows strong representation of DNA-related processes (recombination, replication, base-excision repair, DNA integration) together with cell wall biosynthesis terms (teichoic acid biosynthetic process, cell wall organization, UDP-glucose metabolism). This suggests a bacterial protein cohort coordinating DNA maintenance with cell wall construction, though some xenobiotic or latency terms may reflect broader functions in the dataset.","confidence":"Medium","size":29,"edges":29,"triangles":6,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0006260","count":5},{"id":"GO:0071555","count":5},{"id":"GO:0006284","count":4},{"id":"GO:0006011","count":4}]},{"hash":"748579211757871191","title":"DNA-Templated Transcription Regulation","description":"The top terms are dominated by DNA-templated transcription and its regulation (including initiation), with a secondary signal from mRNA splicing and occasional stress-related processes (heat response, sporulation, antibiotic response). This points to a cluster of nuclear proteins primarily involved in transcriptional control, with RNA processing and stress responses as ancillary features, justifying a label centered on transcription regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0009408","count":5},{"id":"GO:0006355","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0043547","count":3}]},{"hash":"2236694115707462197","title":"Protein folding, trafficking, and quality control","description":"This cluster is dominated by processes related to protein maturation and movement between compartments: protein unfolding, proteasome assembly, and various import pathways (peroxisome, mitochondria, ER-Golgi), plus mRNA export and transcriptional elongation regulation that may reflect broader coordination of gene expression. Collectively, the signals point to a module focused on proteome quality control and intracellular trafficking, with some ancillary nuclear processes.","confidence":"High","size":29,"edges":74,"triangles":108,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":17},{"id":"GO:0051260","count":15},{"id":"GO:0006406","count":15},{"id":"GO:0070682","count":15},{"id":"GO:0016558","count":14}]},{"hash":"2184096894405644992","title":"Ubiquitin-Dependent Proteolysis and Antiviral Immunity","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination) and innate immune responses (defense against virus, TNF signaling), suggesting a proteostasis\u2013immune signaling theme. Some terms like peroxisome import and Wnt receptor catabolic process are ancillary but do not override the core ubiquitin-proteasome/immune link.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:1903265","count":12},{"id":"GO:0051865","count":12},{"id":"GO:0016558","count":12},{"id":"GO:0030433","count":11}]},{"hash":"1465028829001105422","title":"Translation initiation and developmental growth","description":"Most terms center on translation initiation and reinitiation (formation of translation preinitiation complex, translation reinitiation) and RNA guanine-N7 methylation, indicating a core role in protein synthesis. The accompanying terms covering cell proliferation, multicellular development, and growth hormone response suggest coordinated growth and development. Stress-related and cytoskeletal terms (cadmium response, microtubule severing, cohesion) imply concurrent regulation of division and structural dynamics during growth. Overall, the cluster links translation machinery with developmental growth signals.","confidence":"Medium","size":28,"edges":81,"triangles":99,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001731","count":8},{"id":"GO:0030433","count":8},{"id":"GO:0060416","count":7},{"id":"GO:0007064","count":7},{"id":"GO:0008283","count":7}]},{"hash":"1215445138572606074","title":"Transcription and carbohydrate metabolism","description":"These proteins show enrichment for DNA-templated transcription and ribosome biogenesis, indicating roles in gene expression and ribosome production. In addition, multiple carbohydrate metabolism processes (glycogen, trehalose, maltose, sucrose, amylopectin) suggest involvement in energy storage and metabolism. The combination points to a general cellular maintenance cluster balancing transcription machinery with energy metabolism rather than a single, cohesive pathway. Therefore the label Transcription and carbohydrate metabolism summarizes the dominant themes.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0005980","count":2},{"id":"GO:0005978","count":2}]},{"hash":"1001336752808821318","title":"Glycolysis and Redox Homeostasis","description":"This cluster is dominated by glycolytic (GO:0006096) and redox-related terms (GO:0098869, GO:0045454, GO:0055114), plus associated metabolic processes (thiamine, 2-oxoglutarate, and glutamate biosynthesis), indicating a cohesive metabolic and redox-maintenance theme, despite a few unrelated terms.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":5},{"id":"GO:0006096","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0007369","count":4}]},{"hash":"693348794185408651","title":"Unknown","description":"The top GO terms span DNA replication, cell morphogenesis, GTPase activity regulation, SRP-dependent cotranslational targeting to membrane, iron-sulfur cluster assembly, ER stress-related signaling, and fungal beta-glucan biosynthesis, a highly heterogeneous mix with no clear unifying function. This diversity suggests the cluster does not represent a single cohesive biological process, so a definite, representative label is not reliable.","confidence":"","size":28,"edges":15,"triangles":6,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0000902","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006880","count":4},{"id":"GO:1900035","count":4}]},{"hash":"621155290966265019","title":"Unknown","description":"The top GO terms are highly diverse, spanning microbial biosynthetic processes (lipopolysaccharide and antibiotic biosynthesis, tryptophan biosynthesis, mannosylglycerate biosynthesis), a dephosphorylation process, xenobiotic response, and vertebrate muscle physiology (calcium handling and contraction) as well as otolith mineralization. This lack of a single coherent functional theme across the cluster suggests no clear common function, so Unknown with None confidence.","confidence":"","size":27,"edges":32,"triangles":12,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":6},{"id":"GO:0009103","count":6},{"id":"GO:0000162","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0035690","count":4}]},{"hash":"1478585468459996233","title":"Broad developmental transcription regulation","description":"The prominent GO terms show regulation of DNA-templated transcription and several tissue-specific development processes (pituitary gland, metencephalon, gonad, pancreas, ureteric bud), suggesting proteins involved in controlling transcription during development across different tissues rather than a single pathway. Some terms (e.g., response to abscisic acid) may reflect cross-species annotations or broader regulatory roles, introducing noise; thus confidence is moderate.","confidence":"Medium","size":27,"edges":44,"triangles":11,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0006355","count":5},{"id":"GO:0009737","count":4},{"id":"GO:0006990","count":4},{"id":"GO:0043923","count":4}]},{"hash":"1784435720731789384","title":"ER-Golgi trafficking and mitosis","description":"The top terms cluster around ER-to-Golgi transport, COPII vesicle budding, and Golgi-ER retrograde transport, indicating a vesicle trafficking/secretory pathway theme. There are also mitotic-related terms (mitotic spindle assembly, mitotic cell cycle, cell division), suggesting a secondary layer of cell-division involvement. The combination points to proteins linked to both vesicle trafficking and mitosis, with developmental terms present as broader context. ","confidence":"Medium","size":27,"edges":30,"triangles":4,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":8},{"id":"GO:0051301","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0090114","count":7},{"id":"GO:0097284","count":6}]},{"hash":"1496472939701289485","title":"Mitochondrial protein import and stabilization","description":"The cluster is driven by GO terms for protein stabilization and protein import into the mitochondrial matrix, suggesting a proteostasis/mitochondrial import core. Additional terms touch on cell cycle, growth, and signaling (Wnt/SMAD) that point to broader cellular regulation, but the strongest, recurring signal is mitochondrial protein handling. The presence of several obsolete terms reduces perfect clarity, so I assign a moderate level of confidence.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050821","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0030150","count":2},{"id":"GO:0090263","count":2}]},{"hash":"133274638190241190","title":"Ribosome Biogenesis and Nuclear Export","description":"The top GO terms point most strongly to ribosome biogenesis and the export of ribosomal subunits from the nucleus, suggesting a cluster centered on ribosome assembly and nucleocytoplasmic transport. While there are hints of broader nuclear processes (transcription regulation, kinetochore localization, and cell division), the ribosome-related terms are the clearest shared theme among these proteins.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042176","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0000056","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1716885616941996465","title":"Unknown","description":"The top GO terms cover diverse areas including antibiotic biosynthesis, thiamine and tetrahydrofolate metabolism, redox processes, hematopoietic differentiation, and neurotransmitter metabolism, with no clear shared function linking the proteins. The lack of network edges and the heterogeneity of terms suggest there isn\u2019t a cohesive biological theme for this cluster. ","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0009228","count":6},{"id":"GO:0046653","count":5},{"id":"GO:0043046","count":5}]},{"hash":"519137393602607285","title":"Bacterial LPS and Capsule Biosynthesis","description":"This cluster is dominated by GO terms for lipopolysaccharide biosynthesis, colanic acid biosynthesis, and precursor pathways (GDP-mannose, ADP-L-glycero-beta-D-manno-heptose), all linking to bacterial cell envelope polysaccharide production (LPS core, capsule). Additional terms like poly-hydroxybutyrate biosynthesis suggest broader metabolism but do not outweigh the clear envelope polysaccharide theme. ","confidence":"High","size":26,"edges":9,"triangles":2,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":15},{"id":"GO:0042619","count":13},{"id":"GO:0009103","count":11},{"id":"GO:0017000","count":10},{"id":"GO:0006355","count":10}]},{"hash":"55928557674815245","title":"Mitochondrial protein maturation and heat-stress response","description":"This cluster centers on processes related to mitochondrial protein maturation (iron-sulfur cluster transfer, targeting to mitochondrion, protein complex assembly/oligomerization) and cellular defense against stress (response to heat, redox homeostasis, and regulation of ATP-dependent activity). While one term relates to a developmental signaling pathway that seems unrelated (likely annotation noise), the overall theme points to mitochondrial protein maturation combined with stress and redox regulation.","confidence":"Medium","size":26,"edges":79,"triangles":83,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051259","count":9},{"id":"GO:0097428","count":9},{"id":"GO:0006626","count":9},{"id":"GO:1901621","count":9},{"id":"GO:0009408","count":9}]},{"hash":"675651840594437398","title":"Central carbon metabolism and amino acid biosynthesis","description":"Based on GO terms enriched in this cluster, the proteins participate in core carbon metabolism and biosynthesis: glycolysis, the TCA cycle, gluconeogenesis, pyruvate decarboxylation to acetyl-CoA, and biosynthesis of amino acids (lysine, leucine) and cofactors (thiamine), with an additional porphyrin biosynthesis term. Although a sodium transport term appears, the dominant theme is energy production and anabolic metabolism, justifying the label as a cohesive central metabolism and amino acid biosynthesis cluster.","confidence":"High","size":25,"edges":85,"triangles":68,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":9},{"id":"GO:0019878","count":8},{"id":"GO:0006096","count":7},{"id":"GO:0006094","count":5},{"id":"GO:0009228","count":5}]},{"hash":"378990183938796678","title":"Oxidative stress response and vesicle trafficking","description":"The cluster is enriched for redox-related terms (oxidation-reduction process, cellular oxidant detoxification, cellular response to oxidative stress) and detoxification, indicating a redox-focused function. It also includes terms tied to vesicle formation and organelle targeting (intralumenal vesicle formation, Golgi retention, peroxisome import), suggesting a link between oxidative stress responses and vesicular trafficking/organellar protein targeting. Overall, the proteins appear to coordinate redox homeostasis with vesicle trafficking processes.","confidence":"Medium","size":25,"edges":263,"triangles":1553,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045053","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0070676","count":2},{"id":"GO:0034599","count":2}]},{"hash":"356149536120328399","title":"Amino acid catabolism and central metabolism","description":"The top GO terms center on amino acid catabolic processes (L-alanine, L-aspartate, L-lysine, kynurenine) feeding into central metabolism (TCA cycle) and related biosynthetic pathways (biotin, protoporphyrinogen IX). This suggests a coherent theme of amino-acid\u2013driven metabolism and core metabolic flux, with the Notch signaling term appearing as a potential outlier. ","confidence":"Medium","size":24,"edges":268,"triangles":1858,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097053","count":8},{"id":"GO:0042853","count":8},{"id":"GO:0007219","count":8},{"id":"GO:0033512","count":7},{"id":"GO:0006099","count":6}]},{"hash":"1886350662122342922","title":"Vitamin and cofactor biosynthesis in bacteria","description":"The cluster is dominated by biosynthetic processes for vitamins and cofactors (thiamine and molybdopterin), along with aromatic amino acid precursor pathways and related growth-related processes (cell division, cell wall organization), suggesting a cohesive theme of bacterial primary metabolism and essential cofactor/vitamin production.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":4},{"id":"GO:0009229","count":3},{"id":"GO:0071555","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0051301","count":3}]},{"hash":"741764007630232092","title":"Ubiquitin-Proteasome Proteostasis Network","description":"The top GO terms cluster around ubiquitin-related processes (deubiquitination, ubiquitin-dependent ERAD, maintenance of unfolded proteins in ERAD, and proteasome core assembly) and regulation of ubiquitin ligase activity, pointing to a network governing protein quality control and turnover via the ubiquitin-proteasome system and ER-associated degradation; some associated terms touch signaling pathways, but the core theme remains proteostasis through ubiquitination and proteasome function.","confidence":"High","size":24,"edges":207,"triangles":919,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":10},{"id":"GO:0030433","count":7},{"id":"GO:0016032","count":7},{"id":"GO:1904378","count":6},{"id":"GO:0080129","count":6}]},{"hash":"1877548957088102650","title":"Translation Machinery and mRNA Processing","description":"The most represented GO terms are all about protein synthesis and mRNA handling: translation (initiation, elongation, termination), ribosome biogenesis, and nuclear-transcribed mRNA decay and deadenylation. Selenocysteine incorporation also ties to specialized translation. A few entries reference glial cell proliferation and antibiotic response, which may reflect broader regulatory contexts but do not outweigh the translation-centric terms. Overall, the cluster appears to group components of the cellular translation apparatus and mRNA turnover.","confidence":"High","size":24,"edges":179,"triangles":686,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":19},{"id":"GO:0046677","count":9},{"id":"GO:0042254","count":7},{"id":"GO:0045901","count":6},{"id":"GO:0006413","count":6}]},{"hash":"1753849437996448295","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":270,"triangles":1899,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":18},{"id":"GO:0048026","count":17},{"id":"GO:0006369","count":17},{"id":"GO:0000398","count":16},{"id":"GO:0045003","count":14}]},{"hash":"60753653584697177","title":"Unknown","description":"The top terms span diverse processes (glycolysis, amino acid catabolism, redox, translation initiation, development, aging, and ethanol response) with no clear shared function, and there are no connections among proteins (0 edges). This looks like an artifactual or heterogeneous grouping rather than a cohesive biological module.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0070262","count":3},{"id":"GO:0009228","count":2},{"id":"GO:0007568","count":2}]},{"hash":"695928715997992209","title":"Mitochondrial protein import and respiration","description":"Reasoning: The dominant GO terms describe mitochondrial processes\u2014import into the mitochondrial matrix, inner membrane insertion, proton transport, and aerobic respiration\u2014with protein tetramerization likely reflecting assembly of respiratory complexes. A few peripheral terms (B cell chemotaxis, sebaceous gland differentiation, CNS myelin maintenance, insulin signaling) may reflect broader annotations or dataset noise, but do not negate the core mitochondrial theme.","confidence":"Medium","size":24,"edges":13,"triangles":1,"max_degree":7,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0030150","count":4},{"id":"GO:0051289","count":4},{"id":"GO:1902600","count":4},{"id":"GO:0009060","count":4},{"id":"GO:0035754","count":4}]},{"hash":"647963364944015012","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for ribosome assembly, ribosomal subunit export, cytoplasmic translation, and tRNA modification, indicating a core role in ribosome biogenesis and protein synthesis. The presence of cell cycle and cell division terms may reflect coordination between ribosome production and cell growth/division.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":9},{"id":"GO:0000055","count":7},{"id":"GO:1903833","count":7},{"id":"GO:0002181","count":7},{"id":"GO:0007049","count":7}]},{"hash":"1722955655211539429","title":"Cell Division and Nuclear Processes","description":"Dominant GO terms point to mitosis and cell division (cohesion and segregation) and core nuclear activities (DNA-templated transcription, nuclear pore localization). Additional terms suggest developmental context and some stress responses, with a few obsolete annotations, but the primary function appears to be regulation of the cell cycle and nuclear biology.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0007064","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0006349","count":4},{"id":"GO:0031081","count":4}]},{"hash":"449922266641908746","title":"RNA Processing and Translation","description":"This cluster is driven by RNA metabolism signals: polyadenylation/mRNA processing and cytoplasmic translation, with a supporting link to GTPase regulation that can impact translation. Although there are some metabolic terms present, the strongest and most consistent theme is RNA processing and protein synthesis, suggesting a cluster focused on RNA metabolism and translation. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098789","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0033540","count":1}]},{"hash":"1378961251529849444","title":"Unknown","description":"The proteins show a broad mix of GO terms (DNA repair, DNA replication, apoptosis, cell wall organization, plant hormone signaling, and development) with no single dominant function, making it unclear how they cohesively relate functionally.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0071555","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0048240","count":2}]},{"hash":"1497655915906448481","title":"Photosynthesis and light-response proteins","description":"The top terms cluster around photosynthesis, light harvesting in photosystem I, and photoprotective/light-sensing responses (blue, far-red, high/low light, and nonphotochemical quenching), with only a couple of translation-related terms appearing. This suggests proteins involved in photosynthesis and light-triggered regulation rather than unrelated processes.","confidence":"High","size":23,"edges":247,"triangles":1652,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0022417","count":2},{"id":"GO:0018298","count":2},{"id":"GO:0071486","count":2},{"id":"GO:0010218","count":2}]},{"hash":"440315119807478253","title":"Ribosome Biogenesis and Protein Translation","description":"Top GO terms are dominated by translation-related processes: translation itself, translational initiation, and elongation, plus cytoplasmic translation and selenocysteine incorporation. Also represented are ribosome biogenesis/export from the nucleus and mRNA decay, pointing to a cluster of proteins involved in ribosome function and post-transcriptional mRNA processing. A few terms about cell division and glial proliferation are tangential, but the central theme appears to be the machinery and regulation of protein synthesis.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0006413","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0051301","count":5},{"id":"GO:2000767","count":4}]},{"hash":"273781193234009074","title":"Splicing and mRNA Processing Regulation","description":"The cluster shows strong representation of GO terms tied to mRNA splicing and spliceosome function, including positive and negative regulation of mRNA splicing via spliceosome, cis-splicing, splice site recognition, and mRNA modification. These terms indicate a coherent functional theme around RNA processing and splicing control. Some terms like formation of translation preinitiation complex and blastocyst formation are less central, but the dominant signal is spliceosome-mediated mRNA processing.","confidence":"High","size":23,"edges":56,"triangles":35,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0006378","count":12},{"id":"GO:0045292","count":12},{"id":"GO:0016556","count":11}]},{"hash":"930254127080759211","title":"Biosynthesis and Translation","description":"The top GO terms include several biosynthetic processes (histidine, ubiquinone, sterol) alongside translation and regulation of translational fidelity, suggesting a cluster of proteins involved in core cellular biosynthesis and protein synthesis. Some terms are obsolete, which adds noise, but the shared theme centers on metabolism-related biosynthesis and translation machinery.","confidence":"Medium","size":23,"edges":83,"triangles":63,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000105","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0035902","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006744","count":2}]},{"hash":"500710903241821729","title":"Chloroplast Translation and Metabolism","description":"The top GO terms point to chloroplast-associated functions: translation and plastid chromosome packaging, along with nitrogen and sulfur metabolism (nitrate and sulfate assimilation, cysteine biosynthesis, hydrogen sulfide biosynthesis) and related plastid processes. The presence of a viral process term is likely incidental or broad rather than indicative of a core theme. Overall, the cluster seems centered on chloroplast gene expression and core metabolic pathways, even though edges are not observed in the network. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0019344","count":1},{"id":"GO:1900160","count":1},{"id":"GO:0042128","count":1}]},{"hash":"1823152201599012317","title":"TORC1-regulated translation and ribosome biogenesis","description":"The top GO terms center on growth signaling (TORC1 signaling, nutrient response, GTPase activity regulation) alongside translation and RNA processing processes (formation of translation preinitiation complex, rRNA maturation, RNA methylation, mRNA transport), suggesting a cohesive theme of coordinating growth signaling with ribosome biogenesis and translation initiation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038202","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0070262","count":4},{"id":"GO:0001731","count":3}]},{"hash":"853886372648096758","title":"Unknown","description":"The cluster shows a mix of GO terms including response to toxic substances, cell division, DNA replication, biotin biosynthetic and antibiotic biosynthetic processes, methylation, and cell wall organization, with no single dominant function and no edges linking proteins. This broad, fragmented functional spread makes it hard to assign a cohesive, representative label. ","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0032259","count":2}]},{"hash":"2203104921451537628","title":"Central carbon metabolism and amino acid turnover","description":"The cluster is dominated by core energy pathways: glycolysis, gluconeogenesis, and the TCA cycle, along with amino acid catabolic and biosynthetic processes (alanine, serine, oxaloacetate-related). Notch signaling appears among the top terms, suggesting some signaling context, but the overall enrichment points to metabolism and amino acid flux as the defining theme.","confidence":"Medium","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006099","count":7},{"id":"GO:0097053","count":7},{"id":"GO:0042853","count":7},{"id":"GO:0007219","count":7},{"id":"GO:0033512","count":7}]},{"hash":"79798647789595491","title":"Neural development and cell cycle regulation","description":"The set includes terms for neuron differentiation, Schwann cell development, and excitatory synaptic potential, suggesting neural lineage and synaptic function, alongside cell-cycle and DNA replication terms (G1/S transition, CDK regulation, kinetochore localization). This combination indicates a cluster of proteins coordinating neural development with cell-cycle control and associated signaling.","confidence":"Medium","size":22,"edges":155,"triangles":548,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":10},{"id":"GO:0035335","count":9},{"id":"GO:0060079","count":7},{"id":"GO:0014044","count":7},{"id":"GO:0007049","count":7}]},{"hash":"1165336318299549407","title":"LPS and cell-wall glycan biosynthesis","description":"Proteins in this cluster are enriched for lipid A/LPS, O-antigen, and other glycan biosynthetic processes (GDP-mannose, UDP-GlcNAc) and for cell wall organization, suggesting a shared role in assembling the bacterial outer envelope glycans. There is an outlier term (detection of gravity) that doesn't fit the core theme, but the dominant signal is glycan biosynthesis and cell-wall construction.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0005978","count":3},{"id":"GO:0009298","count":3},{"id":"GO:0009243","count":3},{"id":"GO:0019388","count":3},{"id":"GO:0019255","count":3}]},{"hash":"791469291537012278","title":"Bacterial cell envelope biosynthesis and antibiotic response","description":"Top terms cluster around lipopolysaccharide and menaquinone biosynthesis, serine biosynthesis, and an antibiotic response signal, all characteristic of Gram-negative envelope metabolism and stress adaptation. While some terms (retinol/retinal metabolism) are less coherent, the core theme points to cell envelope biosynthesis and related metabolic processes, with antibiotic response as a connected facet.","confidence":"Medium","size":22,"edges":154,"triangles":518,"max_degree":21,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0009234","count":7},{"id":"GO:0009103","count":7},{"id":"GO:0046677","count":6},{"id":"GO:0006564","count":6}]},{"hash":"1082094342842188719","title":"Glycan biosynthesis and cell wall assembly","description":"The cluster is enriched for GO terms related to cell wall polysaccharide biosynthesis and glycan metabolism (cell wall biosynthetic process, mycolate cell wall layer assembly, UDP-sugar and glycosylation-related processes), indicating a functional group of proteins involved in constructing and decorating the cell envelope glycans. Despite some noisy or obsolete terms, the predominant theme points to cell wall glycan biosynthesis and modification.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":2},{"id":"GO:0036108","count":2},{"id":"GO:0070592","count":2},{"id":"GO:0030213","count":2},{"id":"GO:0071555","count":2}]},{"hash":"1657750599589243853","title":"Plant mitochondrial energy production and vacuolar transport","description":"The cluster is dominated by mitochondrial processes (NADH to ubiquinone electron transport, proton transmembrane transport, and mitochondrial complex II assembly) plus heme biosynthetic roles, which are essential for cytochrome function. Additionally, vacuolar organization and protein targeting to the vacuole indicate trafficking to plant vacuoles. There are peripheral membrane-transport terms (sodium, fatty acids) and plant cell wall assembly, which fit a broader membrane- and organelle-associated plant biology context. Overall, it points to a theme of membrane-associated energy metabolism and organelle transport in plant cells.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071668","count":2},{"id":"GO:0070453","count":2},{"id":"GO:1902001","count":2},{"id":"GO:0006783","count":2},{"id":"GO:0034553","count":2}]},{"hash":"1695894751000401886","title":"Protein Translation and Proteostasis","description":"This cluster centers on translation and quality control of proteins, with terms for translation (GO:0006412) and translational fidelity (GO:1990145), plus deubiquitination and apoptosis/senescence regulation, suggesting a proteostasis and cell-fate regulation module. Some other terms appear marginal or pleiotropic, but the core theme is protein synthesis and maintenance of the proteome. ","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006626","count":2},{"id":"GO:0016579","count":1},{"id":"GO:0042981","count":1},{"id":"GO:0043392","count":1}]},{"hash":"1495862612590408011","title":"Growth, Metabolism, and Immune Signaling Cluster","description":"The top GO terms indicate growth-related processes (positive regulation of angiogenesis, multicellular organism growth, regulation of cell proliferation), metabolic responsiveness (cellular response to glucose stimulus), and immune defense (defense response to Gram-positive bacteria), with supporting terms on signaling and proteolysis. This suggests a cohesive theme around cells responding to stimuli that coordinate growth, metabolism, and immune signaling, rather than a single straightforward pathway. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0045766","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0071333","count":7},{"id":"GO:0014068","count":7},{"id":"GO:0045944","count":6}]},{"hash":"1744212838752631333","title":"Blue-light signaling and photoprotection in plants","description":"The top GO terms cluster around blue-light\u2013mediated processes: phototropism, photoreactive repair, photoprotection, and responses to blue light, with circadian regulation supporting a light-signaling theme. While a few terms touch on DNA replication/recombination and miRNA processing, these appear peripheral to the dominant light-responsive functions. Overall, the proteins seem enriched for blue-light sensing and protective responses in plants.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0006260","count":3},{"id":"GO:1903799","count":2},{"id":"GO:0009638","count":2},{"id":"GO:0000719","count":2}]},{"hash":"2164701195697829957","title":"DNA replication and centrosome cycle","description":"The top GO terms cluster around DNA replication, centrosome separation, centrosome cycle, and regulation of the nuclear cell cycle, indicating a core function in cell division and genome maintenance; development-related terms appear less central.","confidence":"High","size":20,"edges":59,"triangles":52,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":15},{"id":"GO:0007100","count":10},{"id":"GO:0007098","count":9},{"id":"GO:0010571","count":9},{"id":"GO:0048701","count":9}]},{"hash":"996974890733427271","title":"Regulation of Signaling and Immune Processes","description":"This cluster shows enrichment for terms related to regulating signaling pathways (such as TGF-beta receptor signaling and phosphatase activity) and immune functions (interferon signaling and complement-mediated cytotoxicity). The presence of several obsolete terms reduces precision, but the common theme is regulatory roles in signaling and immune responses, justifying this label with Medium confidence.","confidence":"Medium","size":19,"edges":41,"triangles":13,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0030511","count":2},{"id":"GO:1901389","count":2},{"id":"GO:0051973","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0045793","count":2}]},{"hash":"2128866702485628253","title":"Development and immune differentiation","description":"The top GO terms point to broad developmental roles across multiple tissues (uterus, ventricular septum, nephric duct, club cell differentiation) and immune system processes (thymic T cell selection, T-helper 2 cytokine production). Some terms related to metabolism or stress response appear but are likely incidental noise. Overall, the cluster seems to reflect coordinated development with immune differentiation, justifying the label.","confidence":"Medium","size":19,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":4},{"id":"GO:0046232","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0045061","count":2},{"id":"GO:0060486","count":2}]},{"hash":"293569810393513573","title":"Ubiquitin-Dependent Degradation and Autophagy in Immunity","description":"Top terms cluster around ubiquitination and autophagy (ubiquitin-dependent ERAD, protein and actin ubiquitination, autophagy) with immune-modulatory signaling (IL-17, T-helper differentiation, LPS signaling, chemokine production) and spleen development. This implies proteins in the ubiquitin-regulated degradation\u2013autophagy axis that modulates immune responses. ","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0007014","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0006914","count":4},{"id":"GO:0045623","count":4}]},{"hash":"1505974524302018723","title":"Mitochondrial metabolite transporters","description":"This cluster is dominated by GO terms for transmembrane transport of diverse mitochondrial cargos (ADP, NAD, CoA, thiamine pyrophosphate, phosphate, iron, ornithine, thiosulfate) into the mitochondrion, plus GO terms for mitochondrial apoptotic changes and regulation of necroptosis. The pattern suggests proteins that facilitate inner-membrane transport of metabolites, with occasional links to mitochondrial stress responses.","confidence":"High","size":19,"edges":56,"triangles":35,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035349","count":14},{"id":"GO:0015866","count":14},{"id":"GO:0008637","count":14},{"id":"GO:0000066","count":14},{"id":"GO:0048250","count":14}]},{"hash":"3065477317591452","title":"Ribosome biogenesis and translation machinery","description":"This cluster is dominated by GO terms related to translation and ribosome biogenesis (translation, cytoplasmic translation, ribosomal subunit biogenesis, small subunit assembly, SSU rRNA maturation, and rRNA export), with additional signals for mitochondrial translation termination; a few peripheral terms (antibiotic response, DNA repair) are present but do not define the core function.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0042254","count":5},{"id":"GO:0006407","count":4},{"id":"GO:0070126","count":3},{"id":"GO:0042274","count":3}]},{"hash":"681945991223677308","title":"Retina development and visual signaling","description":"The top GO terms strongly anchor the cluster to the visual system, with retina vasculature development in the eye and visual perception appearing prominently. Additional terms touch on cell adhesion, integrin signaling, and calcium-dependent exocytosis, which are common in retinal neuron signaling and development. Together, these suggest proteins functioning in eye development and retinal signaling pathways, rather than unrelated processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":2},{"id":"GO:2000811","count":2},{"id":"GO:0036120","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0010763","count":2}]},{"hash":"898010044470318015","title":"Protein lipidation and membrane trafficking","description":"Most of the top GO terms cluster around post-translational lipid modifications (CAAX-box processing, peptidyl-serine octanoylation) and lipid regulation (cholesterol homeostasis, lipoprotein particle levels), with supporting signals for membrane-associated processes like vacuolar acidification and proton transport. Translation and cell growth terms appear less central, suggesting the core theme is lipidation-linked membrane targeting and lipid metabolism.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0016049","count":2},{"id":"GO:0071586","count":1},{"id":"GO:0000032","count":1},{"id":"GO:0007035","count":1}]},{"hash":"1207300005823816867","title":"Mitochondrial and cytosolic translation proteins","description":"The top GO terms are translation and mitochondrial translation, indicating the cluster centers on protein synthesis machinery both in the cytosol and mitochondria; additional terms like tRNA biosynthesis and related metabolism appear secondary, but do not redefine the core theme.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0006171","count":1},{"id":"GO:0006772","count":1}]},{"hash":"254294194880333976","title":"Ribosome Biogenesis and Translation","description":"The cluster shows strong enrichment for translation- and ribosome-related processes, including translation (GO:0006412), cytoplasmic translation (GO:0006400), ribosome biogenesis (GO:0042254), ribosomal subunit biogenesis (GO:0042274) and ribosomal subunit export from the nucleus (GO:0000055, GO:0006407), as well as tRNA modification (GO:0006400). This pattern indicates a cohesive group of proteins involved in ribosome assembly and the protein synthesis machinery, with some ancillary links to cell division and stress response. ","confidence":"High","size":18,"edges":149,"triangles":756,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0042254","count":7},{"id":"GO:0006400","count":4},{"id":"GO:0002181","count":4},{"id":"GO:0006407","count":4}]},{"hash":"2144106840338925455","title":"Nuclear transcription, RNA processing, and ubiquitin regulation","description":"The cluster\u2019s top GO terms cluster around DNA-templated transcription, mRNA splicing, and regulation of RNA polymerase II, together with ubiquitin-related processes (K11-linked ubiquitination and ERAD). This points to a theme of nuclear gene expression control coupled with ubiquitin-mediated protein quality control, rather than a single cytosolic pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0051301","count":2}]},{"hash":"628157956743027949","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009102","count":4},{"id":"GO:0035690","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0000453","count":3}]},{"hash":"1811705087750321349","title":"Potassium and sodium ion transport","description":"The cluster is dominated by GO terms related to ion handling across membranes, notably intracellular potassium ion homeostasis and sodium/potassium export across the plasma membrane, which points to a core function in ion transport and membrane potential regulation. Additional terms like sperm capacitation, inner ear development, and long-term synaptic potentiation are processes that depend on precise ion flux and signaling, supporting a cohesive theme around ion transport in diverse cellular contexts. Therefore, this label appropriately captures the central function of the cluster with high representativeness.","confidence":"High","size":17,"edges":39,"triangles":24,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":5},{"id":"GO:0036376","count":5},{"id":"GO:0097623","count":5},{"id":"GO:0048240","count":3},{"id":"GO:0032092","count":3}]},{"hash":"473698597702210884","title":"Cofactor and Nucleotide Metabolism","description":"The proteins appear to cluster around metabolic pathways involving cofactors and nucleotides, as evidenced by terms like thiamine biosynthetic process, tetrahydrofolate metabolism, 2-oxoglutarate metabolism, and guanine metabolism. Some annotations related to development and differentiation seem incidental or pleiotropic rather than defining the cluster\u2019s core function. This suggests a metabolic hub focused on vitamin and nucleotide-related pathways rather than a single developmental program.","confidence":"Medium","size":17,"edges":42,"triangles":41,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009228","count":7},{"id":"GO:0006103","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0045648","count":6},{"id":"GO:0001701","count":6}]},{"hash":"2031755430701639109","title":"Ribosome biogenesis and RNA processing","description":"Many of the top GO terms cluster around ribosome production and RNA maturation, including translation, tRNA processing, ribosome biogenesis, SSU-rRNA maturation, and RNA pseudouridine synthesis (both rRNA and snRNA), plus spliceosomal assembly and histone mRNA metabolism. This suggests the proteins function together in RNA processing and ribosome assembly pathways, with overlap into mRNA turnover and cell-cycle regulation.","confidence":"High","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0008033","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0030490","count":4},{"id":"GO:0031120","count":3}]},{"hash":"2304348914199216225","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0032981","count":1},{"id":"GO:0045600","count":1},{"id":"GO:0006355","count":1}]},{"hash":"2197094885287221074","title":"DNA Replication and SOS Response","description":"This cluster's top GO terms cluster around DNA replication and genome maintenance, including DNA unwinding and primer synthesis, plus the SOS DNA damage response, suggesting a core theme of replication/repair. The other terms (RNA Pol II promoter clearance, skin/hair development, MDA-5 signaling) appear less connected, likely representing annotation noise or broad multifunctionality; thus the label emphasizes the dominant replication/repair signal.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006268","count":6},{"id":"GO:0009432","count":5},{"id":"GO:0048568","count":5},{"id":"GO:0006269","count":5},{"id":"GO:0043588","count":4}]},{"hash":"966255310485232148","title":"Mitotic Chromosome Assembly and Chromatin Maintenance","description":"The cluster is strongly enriched for mitosis- and chromatin-related terms: cell division and mitotic cell cycle, anaphase-promoting complex\u2013dependent catabolic processes, and CENP-A\u2013containing chromatin assembly, plus histone methylation (H3-K79 and H3-K27) and Okazaki fragment processing in mitotic DNA replication. These co-occur suggesting a cohesive role in chromosome replication/segregation and centromere chromatin maintenance, with ribosome biogenesis appearing ancillary. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0042254","count":3},{"id":"GO:1903461","count":3},{"id":"GO:0061641","count":3}]},{"hash":"1770915469831551057","title":"Dopamine/Serotonin Regulation & Stress Response","description":"These GO terms cluster around dopamine metabolism (dopamine catabolic process; positive regulation of dopamine metabolic process), serotonin regulation (negative regulation of serotonin secretion), and stress or chemical responses (response to corticosterone; response to ethanol). While a couple terms involve general metabolic biosynthesis (ubiquinone, thiamine), the dominant pattern points to neurotransmitter regulation and stress-related responses. ","confidence":"Low","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035195","count":2},{"id":"GO:0006744","count":2},{"id":"GO:0006579","count":2},{"id":"GO:0042420","count":2},{"id":"GO:0014063","count":2}]},{"hash":"1125915460878414385","title":"Protein maturation and oxidative stress response","description":"The GO terms cluster around protein processing and trafficking (N-linked glycosylation; mitochondrial intermembrane space import) plus redox-related maintenance (cellular redox homeostasis; cellular response to oxidative stress). This suggests a shared theme of protein maturation/quality control and stress handling, rather than a single developmental or metabolic pathway. Some terms are developmental or obsolete annotations, but they are not dominant signals in the cluster. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006490","count":3},{"id":"GO:0003384","count":2},{"id":"GO:0007377","count":2},{"id":"GO:0006487","count":2},{"id":"GO:0006696","count":1}]},{"hash":"854513821732071195","title":"RNA processing and translation initiation","description":"These proteins show enrichment for RNA metabolism and initiation of translation, with terms like translation reinitiation, formation of translation preinitiation complex, DNA-templated transcription, and mRNA stabilization indicating involvement in RNA processing and the start of protein synthesis. While a few other terms (forebrain development, ER-stress\u2013related apoptosis, metabolism) appear, they are less representative of the core theme. Therefore, the label RNA processing and translation initiation reasonably captures the cluster\u2019s main function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1895106612443556763","title":"Chromatin regulation and TGF-\u03b2 signaling","description":"This cluster centers on chromatin-related processes (rDNA heterochromatin formation; histone methylation regulation) and growth/signaling pathways (TGF-\u03b2 receptor signaling; positive regulation of stem cell proliferation). While some terms reflect broader development or other processes, the strongest common thread appears to be regulation of chromatin state coupled with growth signaling that influences cell proliferation and development. ","confidence":"Medium","size":16,"edges":114,"triangles":483,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":4},{"id":"GO:0055114","count":3},{"id":"GO:2000648","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0051572","count":3}]},{"hash":"2253824091385644656","title":"Developmental gene expression and cell proliferation","description":"This cluster centers on core gene expression and protein synthesis (DNA-templated transcription; ribosome biogenesis; translational fidelity) and on cell division and development (mitotic cell cycle; cytokinesis regulation; multicellular organism development, forebrain development). The inclusion of growth-related terms and protein interactions (protein homooligomerization) suggests a cohesive theme where transcription/translation control integrates with developmental proliferation and tissue formation, though the diverse terms prevent a single narrowly defined function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006450","count":2},{"id":"GO:0032466","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1195889958098004948","title":"Ribosome and mitochondrial translation machinery","description":"Based on the top GO terms, the cluster is centered on translation, including cytosolic translation, ribosomal large subunit assembly, translation termination, and specifically mitochondrial translation and initiation. This points to proteins involved in the protein synthesis machinery across both cytosolic and mitochondrial compartments, with bacterial-like stress signals (stringent response, antibiotic response) likely reflecting the ancient bacterial origin of mitochondria and shared regulatory themes. Therefore, the label captures the core function of the cluster. ","confidence":"High","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0000027","count":3},{"id":"GO:0006415","count":3},{"id":"GO:0070124","count":2},{"id":"GO:0015968","count":2}]},{"hash":"288772994561126791","title":"Genome maintenance and stress signaling","description":"The cluster centers on genome integrity processes: DNA replication, transcription-coupled repair, kinetochore-associated protein localization, and proteasomal degradation, with linked stress signaling (JNK cascade) and transcription regulation. Translation and antibiotic response terms appear less prominently, suggesting genome maintenance as the core theme.","confidence":"Medium","size":16,"edges":102,"triangles":364,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0032436","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0000902","count":3}]},{"hash":"1192892000011756721","title":"DNA replication and repair with cell-cycle and apoptosis","description":"The top GO terms cluster around nuclear DNA maintenance and cell-cycle control (DNA replication, DNA-templated transcription, DNA repair, mitotic cell cycle) and apoptotic processes, indicating a core function in genome maintenance and programmed cell death. Immune signaling and developmental terms appear, but the dominant pattern is DNA replication/repair and cell-cycle\u2013associated apoptosis, suggesting multifunctional proteins with broader roles rather than a single alternative theme.","confidence":"High","size":16,"edges":36,"triangles":24,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":11},{"id":"GO:0006351","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0006281","count":8}]},{"hash":"1984345024595964122","title":"Mitotic progression and APC-ubiquitin proteolysis","description":"This cluster is dominated by GO terms related to cell division, mitotic cell cycle, and especially APC-dependent proteolysis via ubiquitination (including K11-linked ubiquitination), pointing to proteins that coordinate mitosis and targeted degradation by the ubiquitin-proteasome system. Some peripheral catabolic processes appear among the terms but are not central to the main theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0031145","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0006094","count":2}]},{"hash":"672059725690570544","title":"Central Carbon Metabolism and Amino Acid Biosynthesis","description":"This cluster shows a convergence of core metabolic pathways, including the TCA cycle (GO:0006099) and oxaloacetate metabolism (GO:0006107), porphyrin biosynthesis (GO:0006782), biotin biosynthesis (GO:0009102), and various amino acid catabolic and biosynthetic processes (e.g., L-lysine, L-alanine, L-aspartate, kynurenic acid). The presence of transcription-related activity (DNA-templated transcription) and protein quality control (GO:0006515) alongside these metabolic terms suggests a cohesive module of central metabolism with maintenance/folding processes. Overall, the theme centers on core metabolic functions and amino acid biosynthesis, with ancillary QC elements.","confidence":"Medium","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006782","count":5},{"id":"GO:0006099","count":5},{"id":"GO:0009102","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0019878","count":4}]},{"hash":"1893858830516048435","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster is dominated by ubiquitin-related protein turnover terms (ERAD, ubiquitin-dependent catabolic process, K11-linked ubiquitination, autoubiquitination) and includes receptor turnover (Wnt receptor catabolic process) and cell-cycle growth regulation terms, suggesting a coordinated role in proteolysis and growth control; some peripheral terms may reflect broader regulatory roles.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0070979","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0008283","count":3}]},{"hash":"1252479725484208590","title":"RNA processing and translation regulation","description":"The cluster\u2019s GO terms center on post-transcriptional control: formation of the translation preinitiation complex, translation reinitiation, mRNA splicing via spliceosome, splice site recognition, and mRNA modification. Despite some obsolete terms, the recurring themes point to RNA processing and regulation of gene expression at the mRNA level, with a component of translation initiation control.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0006378","count":5},{"id":"GO:1901407","count":4},{"id":"GO:0045292","count":4}]},{"hash":"364582804701650285","title":"Cell Cycle and Nucleotide Metabolism","description":"The cluster is dominated by mitosis-related terms (mitotic cell cycle, regulation of mitotic metaphase/anaphase transition) and nuclear processes (import into nucleus, activation of protein kinase activity), with supporting nucleotide biosynthesis terms (GTP and GMP biosynthesis). Some outliers like visual perception appear noise, but the core theme points to cell-cycle control linked with nucleotide metabolism.","confidence":"Medium","size":15,"edges":97,"triangles":359,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0006183","count":6},{"id":"GO:0043418","count":6},{"id":"GO:0051289","count":6}]},{"hash":"337339692841441768","title":"Chromatin Assembly and Development","description":"This cluster centers on chromatin assembly and transcriptional regulation (CENP-A chromatin, RNAPol II repression) with multiple developmental processes represented (brain development, osteoblast and gonad development, fertilization) and cell migration/immune-related terms, suggesting a theme of chromatin-based control of development, with a few outliers like defense responses.","confidence":"Medium","size":15,"edges":10,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0006335","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0035264","count":6}]},{"hash":"1265757296424257368","title":"Fungal cell wall mannoprotein biosynthesis","description":"The top GO terms converge on synthesis of cell wall components and glycoproteins, notably cell wall mannoprotein biosynthesis, slime layer polysaccharide biosynthesis, and GDP-mannose\u2013mediated glycan production. These point to a cohesive function in fungal cell wall glycosylation and polysaccharide biosynthesis, with some translation-related terms likely secondary. ","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0031564","count":2},{"id":"GO:0006353","count":2}]},{"hash":"103323422849072857","title":"Xenobiotic and vitamin membrane transporters","description":"This cluster is dominated by terms for transmembrane transport of xenobiotics and vitamins, plus a note about galactose metabolism, pointing to transporter proteins involved in nutrient and foreign compound movement across membranes. Some terms are obsolete or noisy, but the core signal supports a membrane transport/metabolism theme. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006855","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0006012","count":2}]},{"hash":"479140626585557933","title":"Neural Development during Embryogenesis","description":"Top terms point to neuron projection development and embryonic development, suggesting a neural-developmental emphasis in an embryonic context. While several metabolic and chromatin-related terms appear, the most consistent signal is neural development during early stages, hence the proposed label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":3},{"id":"GO:0000183","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0045454","count":3}]},{"hash":"1315987866375627692","title":"Protein Transport and Glycosylation","description":"The cluster\u2019s top GO terms are dominated by protein transport, especially ER to Golgi vesicle\u2013mediated transport and general protein transport, which points to involvement in the secretory pathway. Additional terms relate to glycosylation and glycan biosynthesis (including O-linked glycosylation and UDP-glucose metabolism) and cell-surface polysaccharide assembly, suggesting linked roles in post-translational modification and cell-wall or extracellular matrix glycosylation. Taken together, these terms reflect a cohesive theme around secretory trafficking and glycosylation processes, justifying this label. ","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0015031","count":2},{"id":"GO:0036108","count":1},{"id":"GO:0030213","count":1},{"id":"GO:0071555","count":1}]},{"hash":"2219912496629212192","title":"DNA replication, repair, and recombination","description":"These proteins co-cluster around core genome maintenance processes: DNA replication, DNA repair (including alkylation repair), and DNA recombination, suggesting a coordinated role in preserving DNA integrity. While some terms point to broader stress responses (xenobiotic, cadmium) and circadian regulation, the strongest signals are the DNA metabolism and repair pathways, possibly reflecting assembly of repair and maintenance complexes.","confidence":"High","size":14,"edges":82,"triangles":272,"max_degree":13,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0006281","count":4},{"id":"GO:0042754","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0051260","count":3}]},{"hash":"268047493394326550","title":"Cell signaling and cytoskeletal regulation","description":"Several terms point to regulatory signaling (positive regulation of kinase activities, GTPase activity, and phosphorylation), while Arp2/3\u2013mediated actin nucleation links to cytoskeletal remodeling. The remaining terms (mitotic cycle, hypoxic response, differentiation, and defense) fit as broader contexts for such signaling regulation. Overall, the cluster centers on signaling control and cytoskeletal dynamics.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0001649","count":4},{"id":"GO:0031954","count":3},{"id":"GO:0071456","count":3}]},{"hash":"1992479453584245728","title":"Amino acid biosynthesis and catabolism","description":"The top GO terms point to multiple amino acid metabolism processes (serine, tryptophan, cysteine/homocysteine) and related pathways, plus pyruvate biosynthesis and amine catabolism, suggesting a cohesive function centered on amino acid metabolism and its link to central carbon metabolism. An outlier like \u201cresponse to morphine\u201d is present but does not override the dominant metabolism signal.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"programmed cell death","top_go_terms":[{"id":"GO:0042866","count":8},{"id":"GO:0070689","count":5},{"id":"GO:0019343","count":5},{"id":"GO:0070179","count":5},{"id":"GO:0043418","count":5}]},{"hash":"1517768612893426565","title":"Unknown","description":"The top terms cover a wide range of regulatory themes (mitosis, ubiquitination, metal stress, innate immunity, NFAT signaling, telomere maintenance, post-translational modifications, chromatin history, ciliary motility, and steroid receptor assembly) with no single cohesive function linking them. This scattered mix makes it hard to assign a specific, representative label for the cluster.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0070979","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051534","count":2}]},{"hash":"1041118260145394988","title":"Unknown","description":"The terms span DNA repair and chromatid cohesion, mitochondrial processes, and multiple starvation/nutrient-sensing responses (TORC1 signaling and translation initiation in response to starvation); these do not point to a single cohesive function for the cluster, making a concise, representative label difficult to justify.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007064","count":3},{"id":"GO:0000724","count":3},{"id":"GO:0015886","count":3},{"id":"GO:1904263","count":2},{"id":"GO:0051260","count":2}]},{"hash":"1311016866806009602","title":"P450-dependent xenobiotic metabolism and transport","description":"This cluster appears enriched for cytochrome P450\u2013mediated metabolism and associated transport, highlighted by epoxygenase P450 pathway and xenobiotic catabolic processes (camphor, vitamin D) along with lipid turnover (triglyceride catabolic). Transport terms (glutathione, amino acids, calcium) support a detoxification/metabolism theme, with a few less-connected terms like defense to oomycetes and digestive tract development.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019373","count":2},{"id":"GO:0019433","count":2},{"id":"GO:1990034","count":1},{"id":"GO:0032973","count":1}]},{"hash":"250949389619916186","title":"ER-Golgi Vesicle Transport and Signaling","description":"The top GO terms show strong enrichment for ER-to-Golgi and Golgi-to-ER vesicle transport, suggesting a primary role in membrane trafficking. Additional terms indicate linked signaling and cytoskeletal regulation (GTPase activity, Arp2/3 nucleation), plus metabolic signaling and translation initiation, implying coordinated trafficking with signaling and cellular growth processes. Overall, the cluster seems focused on vesicle transport with associated regulatory functions, though the mix of terms is broad.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0007584","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0034316","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0010255","count":3}]},{"hash":"2256686989366732365","title":"Ribosome biogenesis and translation machinery","description":"Most prominent GO terms are ribosome biogenesis, ribosomal large subunit assembly, and translation, indicating the proteins are involved in ribosome assembly and protein synthesis. Some immune-signaling terms appear in the list but are less represented and do not define the cluster\u2019s main function. Thus this label best captures the core shared role.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0000027","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0070430","count":1},{"id":"GO:1905279","count":1}]},{"hash":"183663931410044765","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006369","count":11},{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0045003","count":6},{"id":"GO:0000390","count":6}]},{"hash":"862375503997051561","title":"Redox and Calcium Signaling in Muscle and Bone","description":"The cluster centers on redox homeostasis and cellular oxidant detoxification, with calcium-signaling terms linked to muscle contraction regulation and osteoblast differentiation, suggesting proteins that balance oxidative stress while modulating Ca2+-dependent pathways in muscle and bone biology. Some outliers (platelet aggregation, regulation of male germ cell proliferation) may reflect broader annotations or less cohesive connections.","confidence":"Medium","size":12,"edges":55,"triangles":130,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":7},{"id":"GO:0098869","count":7},{"id":"GO:0070527","count":5},{"id":"GO:0055114","count":5},{"id":"GO:2000255","count":5}]},{"hash":"2104289855744152558","title":"Unknown","description":"The top GO terms cover a mix of transcription-related processes (DNA-templated transcription and termination, transcription antitermination) and differentiation signals for muscle tissues (cardiac and smooth muscle differentiation, TGF-beta signaling), plus stress responses (antibiotic response, hyperosmotic salinity). There is no single cohesive biological theme linking these terms, and the cluster shows no interactions (Edges 0), so it\u2019s not possible to assign a focused functional label beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0030511","count":1},{"id":"GO:2000727","count":1},{"id":"GO:1904753","count":1},{"id":"GO:0031564","count":1}]},{"hash":"1552259489698584594","title":"Acetylation and chromatin modification","description":"The top GO terms are dominated by acetylation-related processes (histone H4 acetylation, N-terminal and other acetylations, spermidine/putrescine acetylation) with a related chromatin-regulation term (subtelomeric heterochromatin formation). This points to a cohesive theme of protein and histone acetylation governing chromatin structure and gene regulation. A few items like melatonin biosynthesis and angiogenesis are less connected and may reflect broader annotations, but the core signal supports acetylation-based chromatin control.","confidence":"High","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009447","count":8},{"id":"GO:0001525","count":8},{"id":"GO:0045150","count":8},{"id":"GO:0017198","count":8},{"id":"GO:0032918","count":8}]},{"hash":"99316216454298125","title":"Unknown","description":"This cluster shows a mix of diverse, largely unrelated GO terms: rRNA processing, various metabolite biosynthesis pathways, and other cellular processes, with no shared, dominant function across proteins (and no edges linking them). Because there isn't a clear unifying theme, I cannot assign a specific, representative label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0044030","count":2},{"id":"GO:0009102","count":1},{"id":"GO:0006596","count":1}]},{"hash":"1754093615437874482","title":"Meiotic Recombination and Synaptonemal Complex Assembly","description":"The top GO terms are dominated by meiotic processes: chiasma assembly, synaptonemal complex assembly, reciprocal and early/late meiotic recombination nodules, and DNA topological changes related to meiosis, pointing to roles in chromosome pairing and recombination during meiosis. The galactolipid biosynthetic process is an outlier and likely non-representative. Overall, this cluster is best labeled as meiosis-related, centered on recombination and synaptonemal complex formation.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019375","count":1},{"id":"GO:0051026","count":1},{"id":"GO:0006265","count":1},{"id":"GO:0042140","count":1},{"id":"GO:0000706","count":1}]},{"hash":"350508197437231980","title":"Core metabolism and vitamin biosynthesis","description":"The proteins in this cluster are enriched for central carbon metabolism activities (TCA cycle, glucose metabolism) and for biosynthetic pathways of vitamins/cofactors (biotin, cobalamin; NADPH/NADP+ biosynthesis), suggesting a shared role in basic metabolic processes and cofactor production. A couple of terms related to development or hormone response are likely incidental noise relative to the dominant metabolic signals. ","confidence":"High","size":11,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":4},{"id":"GO:0006099","count":3},{"id":"GO:0006740","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0009236","count":3}]},{"hash":"1533099954048432849","title":"Cell proliferation and ER-Golgi trafficking","description":"The top GO terms center on cell proliferation, growth, and division (cell population proliferation, multicellular organism growth, mitotic cell cycle, cell division, mitotic spindle assembly) plus ribosome biogenesis and vesicle transport between the ER and Golgi (COPII-coated vesicle budding, retrograde Golgi-ER transport, ER to Golgi transport). Together these suggest proteins involved in growth and division coordinated with protein synthesis and secretory trafficking, pointing to a theme of proliferative growth linked with the secretory pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":7},{"id":"GO:0035264","count":7},{"id":"GO:0006890","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0000278","count":6}]},{"hash":"1140040129054799059","title":"Cofactor and terpenoid biosynthesis with defense signaling","description":"The cluster centers on biosynthetic pathways for cofactors (riboflavin, nicotinamide nucleotides) and sulfur-containing metabolites (L-cysteine, hydrogen sulfide) as well as terpenoid production via the IPP pathway, indicating a metabolic biosynthesis theme. The presence of defense-related GO terms (systemic acquired resistance, salicylic acid signaling, antibiotic response) suggests an ancillary link to plant defense. Overall, a cohesive interpretation is a metabolic cluster focused on cofactor and terpenoid biosynthesis with supportive defense signaling links.","confidence":"Medium","size":11,"edges":42,"triangles":81,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0009231","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0019344","count":2},{"id":"GO:0070814","count":2}]},{"hash":"318366723157511384","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning ER-Golgi vesicle transport, DNA replication, biotin biosynthesis, peroxisome matrix import, protein unfolding, transcription elongation, phospholipid dephosphorylation, and plant-specific stilbene catabolism, with several obsolete terms. There is no coherent functional theme or dominant process tying the proteins together, so a concise, representative label cannot be determined.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0046839","count":3}]},{"hash":"2001417374860758485","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0000465","count":1},{"id":"GO:0000463","count":1}]},{"hash":"409768857811968256","title":"Telomere Maintenance and Cell Cycle Regulation","description":"The cluster is driven by telomere-related terms (positive regulation of telomerase activity and telomere maintenance via telomerase) along with cell cycle and transcription termination processes, pointing to a nucleus-centric program for genome stability and division. Inflammatory signals and mitochondrial import terms appear as broader supporting themes, but the core pattern centers on telomere maintenance and cell cycle control.","confidence":"Medium","size":11,"edges":44,"triangles":95,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006369","count":6},{"id":"GO:0090666","count":5},{"id":"GO:0051973","count":5},{"id":"GO:2000778","count":5},{"id":"GO:0071866","count":5}]},{"hash":"939288399359781650","title":"Ribosome Biogenesis and Translation","description":"The cluster is enriched for translation-related GO terms, including translation itself (GO:0006412) and ribosome biogenesis/assembly (GO:0042254, GO:0046677, GO:0042273), plus SSU rRNA maturation (GO:0000462) and translation initiation/termination (GO:0006413, GO:0006415) with fidelity maintenance terms. This indicates a cohesive set involved in ribosome construction and the translation process, justifying the label.","confidence":"High","size":11,"edges":46,"triangles":108,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0000462","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0042273","count":2},{"id":"GO:0042254","count":2}]},{"hash":"730104822760020340","title":"K27-linked ubiquitination in immune signaling","description":"This cluster is dominated by GO terms tied to immune signaling and ubiquitination, notably protein K27-linked ubiquitination, cellular responses to interleukin-1 and interferon-beta, and T cell receptor signaling. While there are a few unrelated terms (neuron projection development, prolactin secretion, fungal cell wall organization, telomere maintenance), the core pattern points to ubiquitin-mediated regulation of immune responses. Confidence: Medium","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0044314","count":11},{"id":"GO:0071347","count":11},{"id":"GO:0010976","count":11},{"id":"GO:0051026","count":11},{"id":"GO:0031939","count":11}]},{"hash":"313061166955660440","title":"Retroviral DNA Integration and Latency","description":"The GO terms cluster around steps in the retroviral life cycle: reverse transcription (RNA-templated DNA biosynthetic process), DNA integration, and establishment of proviral latency, alongside viral entry into the nucleus and DNA repair/recombination processes that facilitate integration. Peripheral terms about xenobiotic response and RNAi regulation may reflect host\u2013virus interactions. ","confidence":"High","size":11,"edges":40,"triangles":69,"max_degree":10,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0007568","count":2},{"id":"GO:0006284","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1846722515456465690","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":3},{"id":"GO:0001731","count":2},{"id":"GO:1902416","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0006446","count":2}]},{"hash":"678580638278989249","title":"Unknown","description":"The GO terms cover ribosome biogenesis, multiple transport processes, metabolism, DNA repair, and drug-related transport, with no single dominant function. The sparse connections (one edge, no triangles) and diverse functions suggest this cluster is a mixed collection rather than a cohesive module, so a specific, representative label is not justifiable.","confidence":"","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042274","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0042883","count":1},{"id":"GO:0006635","count":1},{"id":"GO:0042953","count":1}]},{"hash":"628278990895445113","title":"RNA Pol II Transcription Regulation","description":"Many top GO terms point to regulation of transcription by RNA polymerase II (e.g., regulation of DNA-templated transcription, negative regulation of RNA Pol II regulatory region DNA binding). Fe-S cluster assembly-related terms are present but less central, and there are no observed protein-protein edges, suggesting this cluster represents regulatory factors tied to transcription rather than a physical complex devoted to Fe-S biology. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":1},{"id":"GO:0036086","count":1},{"id":"GO:0034396","count":1},{"id":"GO:0044571","count":1},{"id":"GO:0051220","count":1}]},{"hash":"859344567202685777","title":"Mitochondrial metabolite transport","description":"The Top Terms show transmembrane transport of various metabolites and cofactors across the mitochondrial membrane (ADP, NAD, CoA, thiamine pyrophosphate, phosphate, thiosulfate, ornithine, iron), with a minor nod to mitochondrial-related apoptosis terms. This coherent pattern points to proteins involved in mitochondrial transport, hence the label.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035349","count":2},{"id":"GO:0015866","count":2},{"id":"GO:0008637","count":2},{"id":"GO:0000066","count":2},{"id":"GO:0048250","count":2}]},{"hash":"1510754989999009670","title":"Cellular redox homeostasis and detoxification","description":"The cluster's GO profile is strongly enriched for redox and detoxification processes (cellular oxidant detoxification; cell redox homeostasis; oxidation-reduction process). This suggests the proteins collectively maintain redox balance and detoxify reactive species. Other frequent terms reflect stress and signaling responses (response to amino acid; EGF/glucocorticoid stimulus) and immune modulation (negative regulation of IL-1\u03b2 and MCP-1 production), plus regeneration, indicating roles in tissue stress response and repair. The dominant redox-related terms make \"Cellular redox homeostasis and detoxification\" the best concise label.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0045454","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0043200","count":4},{"id":"GO:0071364","count":4}]},{"hash":"305096218848280086","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by ribosome- and translation-related GO terms: translation, cytoplasmic translation, ribosome biogenesis, LSU-rRNA maturation, large subunit assembly/export, and translational initiation/regulation, indicating proteins involved in ribosome assembly and protein synthesis, with some regulatory aspects of translation fidelity.","confidence":"High","size":10,"edges":36,"triangles":66,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0000027","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0000470","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1606593460510967128","title":"Diverse Molecule Transport","description":"The Top Terms show multiple transport-related GO terms across different substrates (cGMP, cysteine, oligosaccharides, lipoproteins, oligopeptides) and a mitochondrial export, suggesting a common theme of moving molecules. There are also regulatory/developmental terms (negative regulation of transcription elongation, stem vascular tissue pattern formation) that are less cohesive with transport but may reflect broader roles of these proteins. Overall, the strongest signal is transport, so this label captures the cluster\u2019s primary function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034244","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0030299","count":2},{"id":"GO:0070731","count":2},{"id":"GO:0042883","count":2}]},{"hash":"2144673794655103641","title":"Developmental Signaling and Cell Cycle","description":"The GO terms point to broad developmental processes (nervous system development, hair follicle morphogenesis, thymus development, multicellular organism development) with a focus on SHH pathway regulation, plus robust cell cycle and division signals. This suggests a cluster of proteins involved in developmental signaling coupled with proliferation across tissues.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0031069","count":4},{"id":"GO:0048714","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0051301","count":4}]},{"hash":"655600838585525903","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000480","count":2}]},{"hash":"1005388054971225408","title":"Plant Development and Chromatin Remodeling","description":"This cluster centers on plant development processes (leaf formation, seed growth) and chromatin regulation (chromatin remodeling, histone modification) with telomere-associated regulation, plus plant hormone and stress responses, suggesting a nuclear chromatin-regulatory role linked to development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0010338","count":3},{"id":"GO:1904792","count":3},{"id":"GO:0080113","count":3},{"id":"GO:0043044","count":3},{"id":"GO:1904850","count":3}]},{"hash":"437138985517852079","title":"Unknown","description":"This cluster's top GO terms span blastocyst formation, peroxisomal protein import, nucleotide-excision repair preincision complex assembly, regulation of actin cable assembly, DNA demethylation regulation, chiasma assembly, JNK cascade regulation, protein ubiquitination, and adaptive immune response. They cover development, DNA repair, cytoskeletal dynamics, epigenetic regulation, signaling, and immunity with no single shared function or pathway apparent across most proteins. Because there is no cohesive theme, the cluster cannot be confidently named beyond Unknown.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0016558","count":1},{"id":"GO:0006294","count":1},{"id":"GO:0090337","count":1},{"id":"GO:1901536","count":1}]},{"hash":"1559307012867794174","title":"Carbohydrate and Fatty Acid Metabolism","description":"The cluster is dominated by terms for glycolysis and fatty acid biosynthesis/oxidation, pointing to central carbon metabolism and lipid metabolism as the core theme. Some outliers (antibiotic biosynthesis, neuron apoptosis) exist but do not overturn the main metabolic signal.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":6},{"id":"GO:0006096","count":4},{"id":"GO:0006635","count":4},{"id":"GO:0051790","count":4},{"id":"GO:0051792","count":4}]},{"hash":"2252241714981295252","title":"Amino acid and porphyrin cofactor biosynthesis","description":"This cluster centers on multiple biosynthetic processes for amino acids and cofactors (biotin, beta-alanine, lysine, arginine) and a porphyrin-related pathway (protoporphyrinogen IX), suggesting a core theme of metabolic production. The presence of GABA catabolic and putrescine catabolic terms, along with an antibiotic biosynthetic term, alongside the stress-related GO term (response to flooding), hints at broader metabolic and stress-response connections in the same protein network. Overall, the label captures the dominant biosynthetic theme with a nod to related metabolic and stress functions.","confidence":"Medium","size":9,"edges":32,"triangles":58,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":5},{"id":"GO:0009102","count":5},{"id":"GO:0019878","count":4},{"id":"GO:0010121","count":3},{"id":"GO:0009447","count":3}]},{"hash":"612814384803759521","title":"Plant metabolism and stress response","description":"Top terms indicate carbohydrate metabolism (galactose/fructose pathways, PPP), lipid oxidation (fatty acid omega-oxidation), lignin biosynthesis, and responses to hypoxia and nutrients, suggesting a plant-centered cluster of diverse metabolic processes tied to environmental stress. The connections are broad rather than a single pathway, justifying the label as a general metabolic/stress cluster in plants.","confidence":"Medium","size":9,"edges":11,"triangles":3,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0007584","count":4},{"id":"GO:0001666","count":4},{"id":"GO:1901159","count":3},{"id":"GO:0046370","count":3}]},{"hash":"457511896362816811","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009229","count":2},{"id":"GO:0009228","count":2},{"id":"GO:0006189","count":1},{"id":"GO:0070329","count":1},{"id":"GO:0046892","count":1}]},{"hash":"1526358659921985640","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045003","count":4},{"id":"GO:0000390","count":4},{"id":"GO:1990416","count":4},{"id":"GO:0034476","count":4},{"id":"GO:0008306","count":4}]},{"hash":"1481215159441434925","title":"Golgi Trafficking and Ribbon Formation","description":"Most of the top GO terms point to Golgi organization and transport: intracellular protein transport, Golgi vesicle transport, Golgi ribbon formation, and retrograde transport from endosome to Golgi. While there are some nucleotide salvage and metabolism terms present, they do not form a cohesive alternative theme. The strongest, cohesive signal is Golgi trafficking/organization, suggesting the proteins function in Golgi-associated transport and structure.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006238","count":1},{"id":"GO:0006206","count":1},{"id":"GO:0015937","count":1},{"id":"GO:0044211","count":1},{"id":"GO:0044206","count":1}]},{"hash":"1000532504652820819","title":"Vesicle trafficking and exocytosis","description":"Top GO terms point to intracellular secretory pathways: ER-Golgi transport, Golgi dynamics (disassembly), intra-Golgi vesicle transport, and exocytic processes including synaptic vesicle docking, neurotransmitter release, and receptor insertion. Some terms (eosinophil degranulation, cornified envelope assembly) reflect secretory activity in diverse cell types. Together, the cluster appears to be centered on vesicle trafficking and secretion.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":2},{"id":"GO:0043311","count":2},{"id":"GO:0010811","count":2},{"id":"GO:0090166","count":2},{"id":"GO:1903575","count":2}]},{"hash":"375138479392478685","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000733","count":1},{"id":"GO:0045002","count":1}]},{"hash":"883691227681666769","title":"P450-Mediated Xenobiotic Metabolism","description":"These proteins show enrichment in cytochrome P450\u2013driven metabolic processes, including epoxygenase P450 pathway and fatty acid omega-oxidation, plus several xenobiotic catabolic activities (camphor, carbazole, alkaloids). While some GO terms touch on development or stress responses, the shared function appears to be detoxification and metabolism of diverse organic compounds via P450 enzymes.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048565","count":1},{"id":"GO:0042369","count":1},{"id":"GO:0019383","count":1},{"id":"GO:0046232","count":1},{"id":"GO:0010268","count":1}]},{"hash":"581562794943865203","title":"Unknown","description":"The top GO terms are highly diverse, spanning translation, rRNA processing, vesicle transport, pheromone signaling, plasmid partitioning, cell cycle, phosphorylation, metal response, and metabolism, with no single dominant function. There are no reported interactions among the proteins (edges 0), so there isn\u2019t a cohesive theme linking the functions. Given this lack of a unifying function, Unknown is the most appropriate label.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000448","count":1},{"id":"GO:0006890","count":1},{"id":"GO:0000750","count":1},{"id":"GO:0030541","count":1}]},{"hash":"795255449843122457","title":"Transcription Regulation and Chromatin Modification","description":"Reason: The top GO terms center on DNA-templated transcription and histone deacetylation, indicating a core role in controlling gene expression via chromatin state. Additional terms point to broader developmental, cell cycle, and stress-response processes, with mitochondrial metabolism as a secondary association.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006120","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0007338","count":2}]},{"hash":"2075017769671386626","title":"Unknown","description":"The terms span nuclear transport (protein import into nucleus, mRNA export, ribosomal subunit export, nuclear pore localization), cytoskeletal remodeling (lamellipodium assembly), and immune signaling (macrophage chemotaxis and inflammatory protein production), plus a meiotic cohesion term and a chloroplast complex assembly term. There isn\u2019t a single coherent biological theme linking these functions, so a definite, representative label is not supported.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":2},{"id":"GO:0010190","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0006406","count":1},{"id":"GO:2000331","count":1}]},{"hash":"1990878096841878037","title":"Mitotic spindle and cytokinesis machinery","description":"This cluster shows a coherent theme around microtubule-based mitosis and cytokinesis, with GO terms for cytoplasmic microtubule organization, mitotic spindle midzone assembly, spindle pole body duplication, cell division, and septum assembly. While metabolic terms appear, the strongest signal is spindle dynamics and division processes, suggesting these proteins work together in mitotic progression and cytokinesis.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006099","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0031122","count":2},{"id":"GO:0001764","count":2}]},{"hash":"2071984172884127811","title":"Redox Homeostasis and Energy Metabolism","description":"The cluster shows a clear emphasis on metabolism and redox balance, highlighted by terms for cellular redox homeostasis and aerobic electron transport. Supporting signals include nucleotide and cofactor metabolism (tetrahydrofolate, guanine) and various catabolic processes, suggesting a metabolic/energy-production theme, with a couple of developmental or regulatory terms as possible noise.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0097428","count":2},{"id":"GO:0001701","count":1},{"id":"GO:0019383","count":1},{"id":"GO:0042208","count":1}]},{"hash":"1587214317504870417","title":"Pentose phosphate and purine salvage metabolism","description":"The top GO terms point strongly to the pentose phosphate shunt (including the non-oxidative branch) and related pentose catabolic processes, plus XMP purine salvage and L-glutamine involvement, together suggesting a module focused on generating ribose-5-phosphate and salvaging purines for nucleotide pools. The presence of a few more general terms (e.g., transcription termination) likely reflects some shared proteins but does not redefine the core metabolic theme. Overall, a cohesive PPP and nucleotide salvage cluster is the most coherent interpretation.","confidence":"High","size":8,"edges":11,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006098","count":3},{"id":"GO:0044262","count":3},{"id":"GO:0009052","count":3},{"id":"GO:0019323","count":3},{"id":"GO:0006541","count":3}]},{"hash":"1685723971264878252","title":"Mitochondrial protein synthesis and import","description":"The cluster\u2019s prominent terms include translation and, notably, protein import into the mitochondrial intermembrane space, along with chaperone-mediated protein complex assembly. These point to a theme of protein production and mitochondrial handling/targeting, with additional support from general cellular metabolism terms. Thus, a label centered on mitochondrial protein synthesis and import best captures the core function represented, with some housekeeping Metab/Division processes included as broader context.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0008616","count":2},{"id":"GO:0042426","count":2},{"id":"GO:0015942","count":2}]},{"hash":"2057522685989817263","title":"Nuclear Transport and Mitosis","description":"This cluster is enriched for nuclear processes: import into the nucleus (NLS-bearing import, regulation of nuclear import), export from the nucleus (tRNA export), and mitotic events (mitotic cell cycle, mitotic nuclear membrane disassembly). The presence of protein oligomerization terms suggests assembly of multi-subunit complexes required for these nuclear functions. Arp2/3-related actin nucleation may support structural remodeling during mitosis, reinforcing the nuclear transport/mitosis theme.","confidence":"High","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0034314","count":2},{"id":"GO:0043981","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0000278","count":2}]},{"hash":"2247428960507293755","title":"Immune and nervous system development","description":"Top GO terms indicate development across immune (thymus development, B cell receptor signaling, T cell differentiation) and neural (nervous system development, Bergmann glial cell differentiation) lineages, along with transcriptional regulation. This pattern suggests a shared theme of developmental regulation spanning immune and nervous system functions, rather than a single, cohesive pathway. Confidence: Medium","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0008209","count":3},{"id":"GO:0046638","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0046677","count":3}]},{"hash":"2300814690061102091","title":"RNA Methylation and Metabolic Biosynthesis","description":"The top GO terms show strong RNA modification signals (tRNA methylation, rRNA guanine-N7 methylation, and peptidyl-lysine dimethylation) alongside several biosynthetic processes (biotin, polyamine, chlorophyll, phosphatidylcholine biosynthesis). This pattern suggests a cluster where RNA methyltransferase\u2013type activities intersect with diverse metabolic pathways, pointing to a theme of RNA modification linked to broader metabolism rather than a single, specific pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030488","count":4},{"id":"GO:0070476","count":4},{"id":"GO:0014075","count":3},{"id":"GO:0018027","count":3},{"id":"GO:0035902","count":3}]},{"hash":"435525483560716664","title":"TORC1 Signaling and Growth Control","description":"This cluster centers on TORC1 pathway involvement with growth and nutrient-responsive processes, reflected by terms like TORC1 signaling, response to nutrient, cell division, and mRNA transport, along with associated regulation of GTPase activity and phosphorylation. While other terms exist (hypoxia response, redox processes), the recurring theme is growth control and metabolic signaling modulated by TORC1, suggesting these proteins function together in nutrient sensing and regulation of cellular growth and translation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0038202","count":2},{"id":"GO:0051028","count":2}]},{"hash":"2167230383348801615","title":"Retinoid and carbohydrate metabolism with signaling responses","description":"Dominant GO terms are retinol/retinal metabolic processes and various sugar-related biosynthesis (fructose, sorbitol), with additional ethanol metabolism and steroid hormone biosynthesis. Signaling-related terms (prostaglandin D response, calcium ion response) and digestion further suggest a broader theme of small-molecule metabolism linked to cellular signaling. The label reflects the strongest, shared themes (retinoid and sugar metabolism) while acknowledging the broader signaling/metabolic context.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":7},{"id":"GO:0042574","count":5},{"id":"GO:0046370","count":5},{"id":"GO:0006068","count":4},{"id":"GO:0006069","count":4}]},{"hash":"1045760603337081491","title":"Plant chromatin remodeling and telomere regulation in development","description":"The top GO terms cluster around chromatin remodeling and telomere maintenance (chromatin remodeling, shelterin/telomere-related regulation), with supportive plant-development terms (leaf formation, seed growth) and plant stress responses (salicylic acid, osmotic stress). This suggests a theme where chromatin state and telomere regulation influence developmental processes and stress adaptation in plants.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010338","count":2},{"id":"GO:1904792","count":2},{"id":"GO:0080113","count":2},{"id":"GO:0043044","count":2},{"id":"GO:1904850","count":2}]},{"hash":"199936008186152117","title":"Ribosome biogenesis and ER-associated quality control","description":"The GO terms center on ribosome assembly (maturation of SSU-rRNA, translation preinitiation complex formation) and protein assembly, plus ER-Golgi transport and ERAD-related quality control, suggesting a cluster involving ribosome production and proteostasis in the secretory pathway. Although there are some development-related terms, the core signal points to translation machinery and ER-associated processing.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0010255","count":2}]},{"hash":"1425556876247242240","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":11,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042619","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0009699","count":3}]},{"hash":"793093748424914925","title":"Oxidative stress and DNA repair","description":"The top terms cluster around oxidative stress response and DNA repair: cellular response to hydrogen peroxide, cell redox homeostasis, and base-excision repair. These indicate proteins involved in protecting genome integrity under oxidative conditions. Other terms in the set, such as aging or skin development, are less consistent with the core theme, suggesting some noise. Overall, the label reflects the strongest shared function in the group.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071375","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0045454","count":1},{"id":"GO:2000327","count":1},{"id":"GO:0006310","count":1}]},{"hash":"676382103625585817","title":"Unknown","description":"This cluster mixes neuronal terms (locomotory behavior, dendrite morphogenesis) with transcription/RNA processing and diverse metabolic processes, with no single coherent function linking all terms.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":2},{"id":"GO:0006364","count":2},{"id":"GO:0045982","count":1},{"id":"GO:0032265","count":1},{"id":"GO:0006353","count":1}]},{"hash":"918714422566116765","title":"Cell Wall Biosynthesis and Stress Response","description":"The GO terms cluster around biosynthesis of cell wall components (peptidoglycan, cell wall polysaccharides, arabinan), suggesting a cell wall biogenesis focus. Additional terms like response to antibiotic and cell division fit with remodeling and wall-associated stress, while some plant-specific or obsolete terms are less informative; overall, the set points to a coherent theme of wall biosynthesis and related stress.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0035884","count":1},{"id":"GO:0009823","count":1},{"id":"GO:0055114","count":1}]},{"hash":"1240821482098372460","title":"Transcription and Cell Cycle Regulation via Polyamines","description":"Core terms point to DNA-templated transcription and cell division, suggesting nuclear regulation and proliferation. Supporting terms like putrescine and spermidine acetylation indicate polyamine metabolism, which commonly links to growth and replication. Some terms (angiogenesis, melatonin biosynthesis) are less cohesive with the core theme, possibly reflecting broader context or annotations, but do not outweigh the main signal. Overall, the cluster appears to center on transcriptional control and cell cycle with metabolic ties to polyamine turnover.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0009447","count":1},{"id":"GO:0001525","count":1},{"id":"GO:0017198","count":1}]},{"hash":"1363709362516229981","title":"Plant light-response and circadian regulation","description":"The set centers on plant photomorphogenesis: phototropism, blue light response, photoprotection, photoreactive repair, and circadian regulation, indicating light-driven growth and stress signaling. Ribosome biogenesis/translation appears as supporting cellular processes, but the dominant theme is light perception and circadian control of function.","confidence":"Medium","size":7,"edges":10,"triangles":4,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0032147","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0009638","count":1},{"id":"GO:0000719","count":1}]},{"hash":"2184657938541794966","title":"Mammary gland development and lactation","description":"The strongest signals are lactation and mammary gland alveolus development, along with epithelial cell differentiation and regulatory pathways like Wnt signaling, which are central to mammary gland formation and milk production. Leptin response further supports a metabolic regulatory context for gland maturation. Some terms (meiosis, broad transcription) are less directly connected, suggesting peripheral or annotation-related associations, but the lactation/differentiation theme remains the best summary.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007595","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0072450","count":1},{"id":"GO:0007129","count":1},{"id":"GO:1903251","count":1}]},{"hash":"1147084218294879706","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009699","count":1},{"id":"GO:0009718","count":1},{"id":"GO:0009243","count":1},{"id":"GO:0009244","count":1},{"id":"GO:0009242","count":1}]},{"hash":"1447905045052104455","title":"Developmental Morphogenesis","description":"These proteins show enrichment for developmental and morphogenetic processes across various tissues (lung epithelium development, midbrain development, neural crest cell migration, spiracle morphogenesis, branching vessel morphogenesis, and polarity axis specification). Some terms (ubiquitin-dependent catabolic process, androgen metabolism, glucosinolate catabolism) are not clearly related, likely reflecting noise or broad cellular regulation, but the dominant signal points to development/morphogenesis.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0060428","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0009911","count":2}]},{"hash":"1324451421106438999","title":"Nucleolar ribosome biogenesis and rRNA transcription","description":"This cluster centers on ribosome biogenesis and rRNA transcription, with strong enrichment for GO terms such as ribosome biogenesis (GO:0042254), rRNA transcription by RNA polymerase I (GO:0042790), and tRNA transcription by RNA polymerase III (GO:0042797), as well as rRNA processing (GO:0006364). These overlapping nucleolar functions together suggest a unified role in nucleolar rRNA synthesis and ribosome assembly, justifying the label. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0042797","count":2},{"id":"GO:0042790","count":2},{"id":"GO:0090503","count":2},{"id":"GO:0001172","count":2}]},{"hash":"1263685954935626336","title":"Acetylation-Driven Protein Modification and Polyamine Metabolism","description":"The top GO terms are dominated by acetylation-related processes (N-terminal acetylation, histone acetylation, and various acetylations of serine, methionine, and spermidine) along with catabolic processes for acetylated compounds (putrescine and acetoin). This points to a common theme of acetylation-based regulation of proteins and metabolism, with chromatin modification (histone acetylation) and polyamine metabolism as connected facets. Some terms (angiogenesis, melatonin biosynthesis, subtelomeric heterochromatin formation) may reflect broader regulatory roles linked to acetylation and chromatin dynamics.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009447","count":7},{"id":"GO:0006474","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0017198","count":7},{"id":"GO:0043967","count":7}]},{"hash":"1829933300453191230","title":"Ubiquitin-Proteasome System and Immune Signaling","description":"This cluster is dominated by GO terms for ubiquitination/deubiquitination and proteasome core assembly, with additional links to cell-cycle regulation and endopeptidase activity, plus immune-related signaling (T cell receptor signaling, inflammatory response regulation) and a plant defense term. The common thread appears to be protein turnover via the ubiquitin\u2013proteasome system influencing signaling and cell-cycle processes.","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":7},{"id":"GO:0080129","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0051436","count":6},{"id":"GO:0010363","count":6}]},{"hash":"1370386757974131877","title":"RNA processing and translation initiation","description":"This cluster is enriched for translation initiation terms (formation of translation preinitiation complex; translation reinitiation) and RNA processing terms (mRNA modification, splice site recognition, and splicing regulation), indicating a cohesive theme around RNA maturation and initiation of translation, despite a few obsolete terms.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0009073","count":1},{"id":"GO:0016556","count":1},{"id":"GO:1902625","count":1}]},{"hash":"981304013213447424","title":"Unknown","description":"The GO terms span chromatin assembly, immune defense (Gram-positive bacterial defense and antibacterial humoral response), cell migration, plasmid partitioning, spermatid development, and plasminogen activation, with two obsolete entries. There isn\u2019t a single cohesive biological function tying these terms together, suggesting this cluster does not reflect one clear theme. ","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006335","count":1},{"id":"GO:0050830","count":1},{"id":"GO:0071674","count":1},{"id":"GO:0030543","count":1},{"id":"GO:0019731","count":1}]},{"hash":"1615874934891441364","title":"Cellular stress response and ubiquitination","description":"The cluster contains GO terms related to stress responses (response to heat, cellular response to mechanical stimulus, response to pain) and protein regulation via ubiquitination, suggesting a cohesive theme around stress signaling and post-translational modification. Telomere maintenance and chromosomal cohesion terms appear less central here, likely reflecting ancillary roles linked to stress or general cellular regulation rather than a single pathway. ","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006777","count":1},{"id":"GO:0071642","count":1},{"id":"GO:0032212","count":1},{"id":"GO:0016567","count":1},{"id":"GO:0071260","count":1}]},{"hash":"1597111147954570025","title":"Lipid catabolism and fatty acid metabolism","description":"This cluster shows several lipid-related catabolic GO terms (lipid catabolic process, triglyceride catabolic process, diacylglycerol catabolic process, arachidonate metabolic process), suggesting a theme around lipid breakdown and fatty acid pathways. Some terms appear unrelated (plant-specific pectin and camalexin processes), which may reflect annotation noise or broader metabolism links, but the lipid-focused terms dominate. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016042","count":1},{"id":"GO:0007216","count":1},{"id":"GO:0045490","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0046340","count":1}]},{"hash":"1924658113993320074","title":"Unknown","description":"The terms suggest several unrelated areas: redox/homeostasis, various catabolic processes (dopamine, camphor), porphyrin biosynthesis, immune defense, development, and transcription regulation. No single dominant function ties the proteins together, and the network metrics show no cohesive module. Hence no specific label; classify as Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0042420","count":1},{"id":"GO:0001701","count":1},{"id":"GO:0042742","count":1}]},{"hash":"1281817540201279038","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0014075","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0044210","count":2},{"id":"GO:0006177","count":2},{"id":"GO:0000105","count":2}]},{"hash":"667094162532261946","title":"Redox Balance and Xenobiotic Degradation","description":"The top GO terms emphasize redox control (redox homeostasis, oxidant detoxification, oxidation-reduction) with additional signals of aromatic compound catabolism (carbazole, toluene) and photosynthetic processes (photosynthesis, nonphotochemical quenching) plus membrane transport. This points to a cluster centered on maintaining cellular redox balance and detoxifying reactive species, potentially tied to chloroplast-associated redox regulation and limited xenobiotic/aromatic degradation activities.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0046232","count":2},{"id":"GO:0042203","count":2}]},{"hash":"1232095966358226414","title":"Heat stress, inflammation, and telomere regulation","description":"The cluster shows a clear presence of heat response, inflammatory signaling (IL-6 production, inflammatory response), and telomere maintenance/telomerase regulation terms, which together point to a shared theme of cellular stress responses linked to survival and genome maintenance. Other terms (mitochondrial protein import, RNA processing in Cajal bodies) appear as supportive or peripheral processes that can accompany stress responses, but the core connection is stress-induced inflammation with telomere regulation.","confidence":"Medium","size":6,"edges":10,"triangles":5,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009408","count":5},{"id":"GO:0090666","count":3},{"id":"GO:0051973","count":3},{"id":"GO:2000778","count":3},{"id":"GO:0071866","count":3}]},{"hash":"558105318974751496","title":"Ribosome Biogenesis and SRP Targeting","description":"This cluster is enriched for GO terms related to SRP-dependent cotranslational protein targeting to membranes, ribosome biogenesis, and translational initiation, with supporting signals from ribosomal export and cell-cycle terms. Together these suggest a core theme of translation machinery assembling and proteins being targeted to membranes during growth and division; the flagellum organization term hints at a bacterial context but doesn't outweigh the translation/assembly signal.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0006616","count":4},{"id":"GO:0006614","count":4},{"id":"GO:0044781","count":4},{"id":"GO:0007049","count":3}]},{"hash":"698211553016329169","title":"Nucleotide Metabolism and DNA Repair","description":"The top GO terms are dominated by nucleotide metabolism activities (AMP salvage, ADP/NMP phosphorylation, CDP biosynthesis, purine ribonucleotide interconversion, ITP metabolism), indicating a core theme of nucleotide synthesis/turnover. DNA repair is also present, suggesting some cluster members participate in genome maintenance as well. Development terms for brain and liver likely reflect broader expression or annotation context rather than a unified developmental role of the cluster.","confidence":"Medium","size":6,"edges":7,"triangles":2,"max_degree":5,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0044209","count":5},{"id":"GO:0006281","count":4},{"id":"GO:0046939","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0046705","count":4}]},{"hash":"2151289272712411992","title":"Lipid biosynthesis and remodeling","description":"Most terms describe lipid biosynthesis/remodeling, including triglyceride, phosphatidylcholine, ether lipid, and cardiolipin pathways, plus CDP-diacylglycerol biosynthesis. A few outliers (cerebellum morphogenesis, cutin biosynthetic process, interleukin-2 production) are peripheral. Overall, the core theme is lipid metabolism.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":1},{"id":"GO:0036151","count":1},{"id":"GO:0006663","count":1},{"id":"GO:0008611","count":1},{"id":"GO:0035965","count":1}]},{"hash":"1444605070390591056","title":"Mitochondrial respiration and ATP synthesis","description":"The cluster is dominated by GO terms tied to the mitochondrial electron transport chain, proton transmembrane transport, aerobic respiration, and ATP synthesis driven by the proton motive force, with the inclusion of Complex III assembly. These collectively point to oxidative phosphorylation as the core shared function of the proteins, making a mitochondria-centered energy-production label appropriate. Some minor terms relate to lipid metabolism, but they do not override the central mitochondrial respiration theme.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006122","count":3},{"id":"GO:1902600","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0034551","count":1},{"id":"GO:0042776","count":1}]},{"hash":"1304097024536145340","title":"Unknown","description":"Top GO terms span glucose signaling, Golgi-to-ER transport, translation preinitiation complex formation, regulation of autophosphorylation, pattern formation, spindle orientation, chromatid cohesion, protein heterotrimerization, imprinting regulation, and cell proliferation. These are diverse cellular processes with no single cohesive function linking all six proteins, and there are no interactions evident (edges/triangles = 0). Therefore a single representative label cannot be confidently assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010255","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0031954","count":2},{"id":"GO:2000011","count":2}]},{"hash":"1660572543914465570","title":"Mammary gland development and epithelial differentiation","description":"The GO terms point to mammary gland alveolus development, lactation, and epithelial differentiation, with supporting signals from canonical Wnt pathways and embryonic development processes. This suggests a small module of proteins coordinating mammary gland morphogenesis and epithelial cell fate during development, with broader links to embryogenesis and transcriptional regulation rather than a single, narrowly defined function.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0072450","count":1},{"id":"GO:0007129","count":1},{"id":"GO:1903251","count":1},{"id":"GO:0045737","count":1}]},{"hash":"426198790393816630","title":"Sphingolipid metabolism and adipocyte differentiation","description":"The top terms center on sphingolipid pathways (sphingosine biosynthesis, sphinganine metabolism) and lipid-related processes, with adipocyte differentiation also represented, suggesting a theme of sphingolipid metabolism and adipogenesis, despite some obsolete terms.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":1},{"id":"GO:0034435","count":1},{"id":"GO:0046512","count":1},{"id":"GO:0033561","count":1},{"id":"GO:0010205","count":1}]},{"hash":"1486660576738100121","title":"Neural and Retina Development","description":"The dominant terms describe neural and eye development: retina vasculature development, CNS neuron development, and dendrite morphogenesis, along with DNA-templated transcription indicating regulatory activity during development. A few metabolic and plant-related terms appear but are less consistent with the main theme, which centers on neural/retinal formation.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":2},{"id":"GO:0048813","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0021954","count":2},{"id":"GO:0043627","count":2}]},{"hash":"168879616647914418","title":"Neurotransmitter metabolism and redox biosynthesis","description":"The Top Terms include dopamine catabolic process and negative regulation of serotonin secretion, indicating neural signaling aspects, while other terms show biosynthesis and redox-related metabolism (hydrogen peroxide, ubiquinone, thiamine). Together they suggest a cluster of proteins involved in both neurotransmitter regulation and core metabolic cofactor biosynthesis, rather than a single tight pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050665","count":2},{"id":"GO:0042420","count":1},{"id":"GO:0019622","count":1},{"id":"GO:0014063","count":1},{"id":"GO:0043420","count":1}]},{"hash":"35109931361447410","title":"DNA Damage Response and Repair","description":"This cluster is dominated by GO terms related to DNA repair and UV-induced damage response, including nucleotide-excision repair, UV-damage excision repair, mismatch repair, and mitotic intra-S DNA damage checkpoint signaling, as well as a response to UV-B. The other terms may reflect ancillary protein processing processes but do not override the central theme of DNA damage sensing and repair. ","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001576","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0006298","count":1},{"id":"GO:0070914","count":1},{"id":"GO:0010224","count":1}]},{"hash":"1019741011695126274","title":"Bacterial cell wall and envelope biosynthesis","description":"The listed GO terms cluster around biosynthesis of cell wall and envelope components in bacteria (peptidoglycan, teichoic acid, lipopolysaccharide, UDP-N-acetylglucosamine) and related cell shape regulation, with terpenoid/isoprenoid pathways supplying envelope lipids. Despite one term for molybdenum cofactor biosynthesis, the dominant theme is bacterial envelope biogenesis, justifying this label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902758","count":1},{"id":"GO:0000902","count":1},{"id":"GO:0016114","count":1},{"id":"GO:0019350","count":1},{"id":"GO:0009252","count":1}]},{"hash":"2104140775253656470","title":"Vacuolar proton transport and acidification","description":"The top GO terms are dominated by proton transmembrane transport and vacuolar acidification, with sodium ion transport also represented. Together these point to membrane transport and pH regulation within the vacuole, suggesting a core role in maintaining ion homeostasis. While a few other terms (e.g., transcription regulation, angiogenesis, starvation response) are present, they appear less central to the main theme, so the proposed label accurately reflects the cluster\u2019s main function.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":2},{"id":"GO:0007035","count":2},{"id":"GO:0015991","count":2},{"id":"GO:0015971","count":1},{"id":"GO:0015970","count":1}]},{"hash":"26103650794592635","title":"Mitochondrial metabolite transport","description":"This cluster is dominated by GO terms for transmembrane transport of various metabolites into mitochondria (e.g., ADP, NAD, coenzyme A, thiamine pyrophosphate, phosphate, iron, thiosulfate) and a term related to apoptotic mitochondrial changes, suggesting a shared function in mitochondrial import/export of metabolic cofactors and substrates, with some connection to mitochondrial apoptosis regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035349","count":3},{"id":"GO:0015866","count":3},{"id":"GO:0008637","count":3},{"id":"GO:0000066","count":3},{"id":"GO:0048250","count":3}]},{"hash":"1721365477258320761","title":"Diverse catabolic metabolism","description":"The cluster is characterized by a set of GO terms largely centered on catabolic processes across a variety of substrates (biotin, triglycerides, chlorophyll, xenobiotics such as 1,2-dichloroethane, stilbene, glucuronosides) and a related epoxygenase P450 pathway, pointing to involvement in broad metabolic turnover rather than a single substrate-specific function. This cohesive theme of multiple, substrate-diverse catabolic processes supports a label of broad metabolic catabolism.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":2},{"id":"GO:0046839","count":2},{"id":"GO:0019373","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0015996","count":2}]},{"hash":"2033016353525083161","title":"Carbohydrate catabolic pathways","description":"The cluster's GO terms predominantly describe catabolic processes for various sugars and sugar derivatives (glycerol, rhamnose, arabinose, xylose, fucose, glucuronate), suggesting a shared function in carbohydrate degradation and sugar metabolism. A few immune-related terms appear sporadically and do not override the central sugar-catabolism theme.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019563","count":1},{"id":"GO:0019301","count":1},{"id":"GO:0019569","count":1},{"id":"GO:0009372","count":1},{"id":"GO:0046167","count":1}]},{"hash":"545091483727914527","title":"Bacterial cell envelope biosynthesis","description":"The top GO terms cluster around biosynthetic processes for envelope-associated components: colanic acid (an exopolysaccharide) biosynthesis, ADP-L-glycero-beta-D-manno-heptose (an LPS core precursor) biosynthesis, galactose metabolism, and ether lipid biosynthesis, plus lysine biosynthesis. These together suggest a thematic link to synthesis of bacterial cell envelope and related membrane components, despite some noisy regulatory terms. Confidence: Medium","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":1},{"id":"GO:0009242","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0097171","count":1},{"id":"GO:0006541","count":1}]},{"hash":"175175809060052688","title":"Glycolysis and glycerol-3-phosphate metabolism","description":"This cluster shows glycolysis/gluconeogenesis and glycerol-3-phosphate metabolism with NADPH regeneration, plus glycerophospholipid synthesis, hinting at a coordinated metabolic module.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006094","count":3},{"id":"GO:0016558","count":2},{"id":"GO:0046168","count":2},{"id":"GO:0006740","count":2},{"id":"GO:0045821","count":2}]},{"hash":"1032849221558379745","title":"One-Carbon Metabolism and RNA Modification","description":"The GO terms cluster around two related themes: one-carbon metabolism (tetrahydrofolate pathway, glycine cleavage, methylation, betaine/choline catabolism) and RNA-related processes (RNA modification, tRNA processing, methylation). This suggests proteins in this cluster participate in folate-dependent donor/acceptor metabolism that fuels RNA modification and processing steps, hence a unified label capturing both.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009451","count":1},{"id":"GO:0006579","count":1},{"id":"GO:0046653","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0042426","count":1}]},{"hash":"116276053422287762","title":"Cardiac TGF-beta signaling and calcium handling","description":"The top GO terms point to transforming growth factor beta receptor signaling, calcium-mediated signaling, regulation of ryanodine-sensitive calcium release, regulation of cardiac conduction, and smooth muscle contraction. Together, these suggest a cluster centered on signaling pathways that control calcium dynamics and excitability in muscle tissue, especially the heart. Some terms (cell cycle, protein folding) seem more general stress-related annotations, but the core theme is cardiac signaling and calcium handling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007179","count":2},{"id":"GO:0051775","count":2},{"id":"GO:0061077","count":2},{"id":"GO:0006939","count":2},{"id":"GO:0007049","count":2}]},{"hash":"1864426322048071639","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms related to translation and ribosome biogenesis, including translation (GO:0006412), ribosomal large subunit assembly (GO:0000027), and assembly of large subunit precursors (GO:1902626), with supporting terms for ribosome biogenesis regulation and mitochondrial translation termination. A couple of terms (DNA metabolic process, interleukin-4 response) are less central and may reflect broader or off-target annotations, but the core pattern clearly points to components of the ribosome assembly and protein synthesis machinery.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000027","count":1},{"id":"GO:0071353","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0006259","count":1}]},{"hash":"2247778105578116658","title":"Ribosome and Translation under UV/DNA Damage","description":"This cluster is dominated by translation- and ribosome-associated terms (translation, translational termination, ribosomal large subunit assembly, mitochondrial translation), indicating core involvement in protein synthesis. A subset of terms links to cellular responses to UV and DNA damage (UV, gamma radiation, p53-mediated signaling, regulation of translation in UV response), suggesting translation machinery that is modulated under DNA damage/UV stress.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006415","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0032543","count":1},{"id":"GO:0034644","count":1}]},{"hash":"1690938880807427425","title":"Translation machinery (cytoplasmic and mitochondrial)","description":"Dominant GO terms are translation-related, including cytoplasmic translation and mitochondrial translation, with additional signals of response to translation inhibitors (antibiotic, cycloheximide). A few other terms (development, DNA repair) are few and likely incidental in this small cluster, so the core function is protein synthesis machinery. ","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0046898","count":1},{"id":"GO:0032543","count":1},{"id":"GO:1990090","count":1}]},{"hash":"1466394289571755360","title":"Ribosome Biogenesis and Export","description":"The Top Terms heavily point to ribosome biogenesis (ribosomal subunit assembly, ribosome biogenesis) and export from the nucleus, indicating a cluster of proteins involved in ribosome production and nucleocytoplasmic transport. A couple of terms about shoot development are likely incidental. Therefore the label Ribosome Biogenesis and Export captures the core theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000032","count":1},{"id":"GO:0006407","count":1},{"id":"GO:0031581","count":1},{"id":"GO:0090506","count":1},{"id":"GO:0034198","count":1}]},{"hash":"984915917416487306","title":"Ribosome Biogenesis and RNA Processing","description":"The top GO terms are dominated by ribosome biogenesis and rRNA maturation, with supporting signals from transcription and growth-related processes; trafficking and mitotic terms appear but are less central, suggesting a core focus on ribosome assembly and RNA maturation with secondary involvement in growth and cell cycle activities.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0006890","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000463","count":2}]},{"hash":"1497909866477079223","title":"Unknown","description":"The top GO terms cover very disparate processes: lipid/phospholipid transport and glycerol metabolism, meiotic cytokinesis, axonogenesis, guard cell morphogenesis, rRNA maturation, and phosphate ion homeostasis. There is no clear, shared function uniting these proteins, and with only a single edge between two proteins, the cluster does not map to a single coherent biological role. Therefore, an Unknown label best reflects the lack of a consistent theme.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015914","count":1},{"id":"GO:0007111","count":1},{"id":"GO:0007409","count":1},{"id":"GO:0030643","count":1},{"id":"GO:0034478","count":1}]},{"hash":"1873419298585285562","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":2},{"id":"GO:0006294","count":1},{"id":"GO:0070911","count":1},{"id":"GO:0006295","count":1},{"id":"GO:0006362","count":1}]},{"hash":"1160169142308333231","title":"NF-kappaB signaling regulators","description":"Based on the top GO terms, the cluster includes explicit NF-kappaB\u2013related processes (I-kappaB phosphorylation; regulation of non-canonical NF-kappaB signal transduction) and redox-responsive terms (cell redox homeostasis, cellular response to hydrogen peroxide) that commonly modulate NF-kappaB signaling. Other terms such as lipoprotein biosynthesis, extracellular matrix organization, and spermatogenesis are likely noisy annotations or reflect diverse protein content, but the presence of NF-kappaB\u2013related terms suggests the proteins preferentially participate in NF-kappaB regulation. Therefore, label NF-kappaB signaling regulators with moderate confidence.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070940","count":2},{"id":"GO:0019471","count":1},{"id":"GO:0042158","count":1},{"id":"GO:0007252","count":1},{"id":"GO:0030198","count":1}]},{"hash":"66392170888281176","title":"Nucleotide metabolism and RNA editing","description":"This cluster shows a coherent set of GO terms centered on nucleotide metabolism (cytosine/guanine catabolic processes, UMP/uridine biosynthesis, deoxycytidine/cytidine deamination, nucleotide salvage) and a specific RNA-editing process (tRNA wobble A-to-I). A few terms like response to antibiotic or riboflavin biosynthesis are ancillary but do not override the core nucleotide-focused theme.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019858","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0006147","count":2},{"id":"GO:0002100","count":2},{"id":"GO:0044206","count":2}]},{"hash":"1428752798355895583","title":"Unknown","description":"The GO terms are diverse (dopamine catabolic, serotonin regulation, ubiquinone and thiamine biosynthesis, response to selenium) with no common pathway or interaction pattern, so there is no coherent function uniting this cluster.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042420","count":1},{"id":"GO:0050665","count":1},{"id":"GO:0019622","count":1},{"id":"GO:0014063","count":1},{"id":"GO:0043420","count":1}]},{"hash":"1536703613686100924","title":"N-linked glycosylation","description":"The cluster\u2019s top GO term is protein N-linked glycosylation (GO:0006487). This points to a shared involvement in adding N-linked glycans to proteins, suggesting a glycosylation-related theme. However, only one of the five proteins carries this annotation, so the connection is tentative and the label reflects the primary functional hint rather than strong, broad support.","confidence":"Low","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006487","count":1}]},{"hash":"996591725694824061","title":"Photosystem II and ion transport proteins","description":"GO terms suggest a link to photosynthesis, especially photosystem II assembly and light reactions, together with several transmembrane ion transport terms (sodium and phosphate). This implies a cluster of proteins associated with the photosynthetic apparatus and membrane transport, with some additional metabolic annotations that may be incidental. Overall, the proteins appear to group around photosystem II-related function and membrane transport.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":2},{"id":"GO:0010207","count":1},{"id":"GO:0010205","count":1},{"id":"GO:0042549","count":1},{"id":"GO:0015979","count":1}]},{"hash":"1452734200531723589","title":"Phospholipid Biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for phospholipids (phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol) and related lipid signaling, suggesting a cohesive lipid metabolism theme for this cluster. While there are a couple of stress response terms and a cell-cycle term, the central signal is phospholipid biosynthesis and regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070317","count":2},{"id":"GO:0006646","count":2},{"id":"GO:1905711","count":2},{"id":"GO:0006659","count":2},{"id":"GO:0006663","count":2}]},{"hash":"1220251535750649830","title":"Mitotic chromatin remodeling","description":"The cluster centers on mitotic cell cycle and cell division, with strong signals for chromatin assembly and organization (nucleosome dynamics, chromatin disassembly) and links to histone modification and transcription elongation, suggesting a cohesive role in reconfiguring chromatin during mitosis.","confidence":"High","size":5,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006335","count":1},{"id":"GO:0006348","count":1},{"id":"GO:0006336","count":1}]},{"hash":"667034362231270459","title":"Galactose-regulated transcription and carbohydrate metabolism","description":"The top GO terms point to both transcriptional regulation and carbohydrate metabolism linked to galactose: DNA-templated transcription and positive regulation of transcription by galactose, alongside metabolism of galactose, galactitol, and D-galacturonate. This suggests a cohesive module where galactose sensing or response drives transcriptional changes to support galactose utilization, with accompanying carbohydrate metabolism pathways. Some mevalonate pathway terms appear, but the dominant theme remains galactose-responsive transcription and sugar metabolism.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0046396","count":1},{"id":"GO:0061623","count":1},{"id":"GO:0019287","count":1},{"id":"GO:0042352","count":1}]},{"hash":"284937914767852997","title":"Mitochondrial translation and tRNA charging","description":"The cluster is dominated by GO terms related to translation and, especially, mitochondrial tRNA aminoacylation (charging) for multiple tRNAs, along with translation fidelity and related selenocysteine biosynthesis; together these suggest a cohesive module for mitochondrial protein synthesis machinery.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097056","count":1},{"id":"GO:0015966","count":1},{"id":"GO:0006450","count":1},{"id":"GO:0016260","count":1},{"id":"GO:0070159","count":1}]},{"hash":"404086741520813036","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051026","count":1},{"id":"GO:0007129","count":1},{"id":"GO:0002047","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0009405","count":1}]},{"hash":"1635486083927867580","title":"Unknown","description":"The top GO terms span both RNA modification (tRNA wobble uridine modification, tRNA methylation) and broad areas like central metabolism (2-oxoglutarate, glutamate biosynthesis), catabolic processes, immune response, and neuronal development, with no single cohesive function linking them. This heterogeneity makes a meaningful, concise cluster label unlikely to reflect true biology.","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0002098","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0042420","count":1}]},{"hash":"1233417230207911616","title":"Actin Remodeling and Muscle Fiber Assembly","description":"These proteins cluster around actin cytoskeleton dynamics and muscle structure, with terms like actin cortical patch assembly, Arp2/3-mediated actin nucleation, mitotic actomyosin contractile ring assembly, and skeletal muscle fiber assembly/adaptation. The dominant theme is actin remodeling and the formation/maintenance of muscle fibers, with a couple chromatin-related terms serving as minor, likely unrelated, outliers.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":3},{"id":"GO:0071963","count":3},{"id":"GO:1903475","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0043503","count":3}]},{"hash":"1679103616731312246","title":"Central metabolism and quinone biosynthesis","description":"This cluster shows a focus on core energy/carbon metabolism, with terms for canonical glycolysis, gluconeogenesis, and D-galactonate catabolism, alongside biosynthetic pathways for quinones (phylloquinone and menaquinone). While a few terms pertain to other cellular processes (e.g., cell wall organization, vacuole fusion, tissue regeneration), the dominant signals point to central metabolism and vitamin K biosynthesis, justifying aMid-level confidence in this label.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009405","count":1},{"id":"GO:0032889","count":1},{"id":"GO:0006094","count":1},{"id":"GO:0009234","count":1},{"id":"GO:1903298","count":1}]},{"hash":"1866520671591507038","title":"Proteostasis and organelle trafficking under stress","description":"The cluster shows enrichment in protein quality control (ER unfolded protein response, chaperone-related refolding, proteasomal degradation) and trafficking across organelles (mitochondria, peroxisomes, SNARE-mediated processes), plus stress-related activities like stress granule disassembly and mRNA export. While UV repair is present, the dominant theme is cellular proteostasis and inter-organelle transport during stress, justifying this label.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070914","count":3},{"id":"GO:0030968","count":3},{"id":"GO:0016562","count":3},{"id":"GO:0035494","count":3},{"id":"GO:1901800","count":3}]},{"hash":"441414655345023743","title":"Negative regulation of chromatin silencing and transcription","description":"The top GO terms cluster around chromatin silencing regulation, histone deacetylation, and repression of transcription (including RNA polymerase I and miRNA transcription), with related aging/telomere silencing terms. A couple of outlier terms on mitophagy and calcium signaling appear less central, so the main theme is chromatin-based control of gene expression.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001308","count":2},{"id":"GO:0070933","count":2},{"id":"GO:0031939","count":2},{"id":"GO:1902894","count":2},{"id":"GO:0016479","count":2}]},{"hash":"1257029760880999837","title":"Viral life cycle and host interaction","description":"The Top Terms show multiple entries tied to viruses: viral life cycle, virion assembly, viral release from host cell, and symbiont entry into host, with leukocyte migration indicating host immune response. These point to a cohesive theme of virus-host interactions, despite a few outlier terms (SOS response, sepal formation) that do not fit the core viral theme.  ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009432","count":2},{"id":"GO:0019058","count":1},{"id":"GO:0010849","count":1},{"id":"GO:0050900","count":1},{"id":"GO:0019068","count":1}]},{"hash":"947009803434221758","title":"Xenobiotic and metal stress response","description":"The GO terms predominantly indicate cellular responses to xenobiotics and various metal ions (cobalt, lead, arsenic, selenium), along with other stress-related stimuli (hypoxia, ionizing radiation, glucocorticoids). This suggests a broad stress-response cluster rather than a single pathway, justifying a label that centers on environmental/toxicant stress responses.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0032025","count":1},{"id":"GO:0043200","count":1},{"id":"GO:0071284","count":1},{"id":"GO:0006782","count":1}]},{"hash":"1385423212211496617","title":"Unknown","description":"The terms are scattered across mitochondrial maturation, heat response, redox balance, and even unrelated signaling contexts (parathyroid hormone stimulus, dorsal/ventral neural patterning), with several obsolete GO terms. There is no clear, single functional theme linking all four proteins, so a concise, representative label isn\u2019t supported by the GO terms available. ","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051259","count":2},{"id":"GO:0097428","count":2},{"id":"GO:0006626","count":2},{"id":"GO:1901621","count":2},{"id":"GO:0009408","count":2}]},{"hash":"371826684628048704","title":"Gene Expression and Translation Machinery","description":"The cluster is defined by strong signals for translation (cytoplasmic and general) and DNA-templated transcription, with additional evidence of protein oligomerization, suggesting participation in multi-subunit gene expression machinery. Some stress-related terms (response to antibiotic, amino acid starvation regulation) imply regulation under nutrient or drug stress, but core themes remain expression and assembly.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0046677","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0002181","count":2}]},{"hash":"690280929217687260","title":"Proteostasis and stress response","description":"This cluster centers on protein folding/refolding and ubiquitin-dependent degradation, pointing to protein quality control (proteostasis) and handling of misfolded proteins. Supporting terms like protein complex oligomerization and heat/redox stress responses further reinforce a role in maintaining protein homeostasis under stress. Some unrelated or obsolete GO terms appear as noise, but the core signals fit proteostasis and stress response.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006457","count":2},{"id":"GO:0051259","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0042026","count":1}]},{"hash":"1232810211806668972","title":"Vesicle trafficking and microtubule dynamics","description":"Top GO terms emphasize ER-to-Golgi vesicle transport and microtubule severing, suggesting a shared role in intracellular transport and cytoskeletal remodeling that can influence cell division. While some annotations (RNA methylation, ion transport) appear unrelated, the core pattern points to trafficking and cytoskeleton regulation as the cluster\u2019s common theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051260","count":2}]},{"hash":"487617271770107904","title":"Ubiquitin-regulated immune signaling","description":"Among the four proteins, the top GO terms cluster around immune signaling (cellular response to interleukin-1, cellular response to interferon-beta, T cell receptor signaling) and a specific ubiquitination mechanism (K27-linked ubiquitination). This suggests a core theme of ubiquitin-mediated regulation of immune signaling. Some terms (neuron projection development, chromatin maintenance, fungal cell wall organization, prolactin secretion) are less coherent with this theme and may reflect pleiotropy or annotation noise, but the dominant pattern points to ubiquitin-regulated immune signaling.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0044314","count":4},{"id":"GO:0071347","count":4},{"id":"GO:0010976","count":4},{"id":"GO:0051026","count":4},{"id":"GO:0031939","count":4}]},{"hash":"2060432166779710128","title":"Unknown","description":"The top GO terms span both developmental processes (eye morphogenesis, cell cycle regulation, myeloid differentiation) and diverse pigment/quinone biosynthesis (plastoquinone, phylloquinone, menaquinone, ubiquinone, chlorophyll, heme O, vitamin K). There is no single coherent function tying these terms together for this cluster, so a meaningful label cannot be confidently assigned. ","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000495","count":1},{"id":"GO:0007050","count":1},{"id":"GO:0002318","count":1},{"id":"GO:0010236","count":1},{"id":"GO:0009234","count":1}]},{"hash":"333692571599144497","title":"Ribosome Biogenesis and Translation Initiation","description":"Based on the most represented terms, the cluster centers on ribosome assembly and the formation of the translation preinitiation complex, indicating a focus on protein synthesis machinery. There are also clear links to cell division and cytokinesis regulation, suggesting a connection between translation capacity and cell cycle progression. A few terms related to vesicle transport, viral mRNA export, and other signaling pathways appear as broader or ancillary annotations, but do not dominate the cluster\u2019s theme. Therefore, the label reflects a cohesive theme around ribosome biogenesis and translation initiation with a link to cell division.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0046784","count":1},{"id":"GO:0050773","count":1}]},{"hash":"1558381569721775004","title":"Actin remodeling and Rac-GTPase signaling","description":"The top GO terms cluster around actin filament reorganization, podosome assembly, Rac/GTPase regulation, and membrane/tubulation processes, indicating a central theme of actin cytoskeleton dynamics governed by small GTPases and membrane remodeling. A few terms are less connected (lipoprotein assembly, floral organ abscission), but do not override the main signal of cytoskeletal regulation.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030037","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0071803","count":3},{"id":"GO:0034379","count":3},{"id":"GO:1903527","count":3}]},{"hash":"1655826061351256323","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0042769","count":3},{"id":"GO:0006296","count":3},{"id":"GO:0016558","count":2},{"id":"GO:0006294","count":2}]},{"hash":"1956493489676444930","title":"Plant quinone and pigment biosynthesis","description":"The cluster is dominated by GO terms for chlorophyll and various quinone/vitamin K biosynthesis (phylloquinone, plastoquinone, menaquinone, ubiquinone) and chloroplast-related pigment production, pointing to a plant-specific metabolic module for pigment and electron-carrier biosynthesis. Pollen development is another plant-specific process in the set, while an unrelated DNA repair term appears incidental. This supports a cohesive label around plant pigment and quinone biosynthesis.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070894","count":1},{"id":"GO:0010236","count":1},{"id":"GO:0009234","count":1},{"id":"GO:0042371","count":1},{"id":"GO:0032194","count":1}]},{"hash":"430482891390538927","title":"Protein and RNA methylation enzymes","description":"The top GO terms are dominated by methylation-related processes (peptidyl-lysine dimethylation, N-terminal methylation, arginine methylation, and tRNA methylation), suggesting the cluster comprises methyltransferases or methylation-associated proteins. Other biosynthetic terms appear secondary, possibly reflecting organism-specific pathways co-occurring with methylation machinery. This name captures the strongest shared function across the proteins.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0018027","count":2},{"id":"GO:0006596","count":2},{"id":"GO:0036068","count":2},{"id":"GO:0009877","count":2},{"id":"GO:0000122","count":2}]},{"hash":"522612872510286498","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016446","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0000734","count":1},{"id":"GO:0045876","count":1},{"id":"GO:0006295","count":1}]},{"hash":"1420568230278166027","title":"Steroid and lipid biosynthesis","description":"This cluster centers on biosynthetic processes for lipids and hormone-related molecules, including sphingolipids, very long-chain fatty acids, estrogen and androgen metabolism, and retinoic acid biosynthesis, suggesting a shared role in lipid/hormone production. Some terms (e.g., transcription regulation, certain plant secondary metabolite processes) are less tied to lipids, but the dominant signal is lipid and hormone biosynthesis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030324","count":3},{"id":"GO:0045150","count":3},{"id":"GO:0030148","count":3},{"id":"GO:0009710","count":3},{"id":"GO:0006355","count":3}]},{"hash":"1445027841062183922","title":"Plasma membrane solute transporters","description":"The GO terms point to transport across the plasma membrane for diverse substrates (trehalose, fructose, phosphate, selenite, xenobiotics, L-ascorbic acid) and osmotic stress response, plus vesicle-related transport. This suggests a cluster of membrane transport proteins handling solute uptake and osmotic regulation, with some involvement in vesicular transport.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060731","count":1},{"id":"GO:0015771","count":1},{"id":"GO:0006970","count":1},{"id":"GO:1900754","count":1},{"id":"GO:0097080","count":1}]},{"hash":"452684446924494043","title":"RNA pseudouridylation and mitochondrial ribosome assembly","description":"This cluster is dominated by GO terms for pseudouridine synthesis in tRNA, snRNA, and mRNA, along with mitochondrial ribosome assembly, suggesting a core theme around RNA modification and mitochondrial ribosome biogenesis. The other carbohydrate metabolism terms are sparse and likely incidental noise. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031119","count":1},{"id":"GO:0031120","count":1},{"id":"GO:1990481","count":1},{"id":"GO:0061668","count":1},{"id":"GO:0006067","count":1}]},{"hash":"174199768082316981","title":"Amino acid catabolism with sugar transport","description":"These proteins show enrichment for several catabolic processes of amino acids (tyrosine/phenylalanine derivatives) and related aromatic compounds, plus transmembrane transport of sugars like D-arabinose and D-glucose. While there are a few ancillary terms related to membrane trafficking and oxidative stress signaling, the dominant theme is metabolic breakdown pathways for aromatic amino acids and sugars, indicating a metabolism-oriented cluster with some transport elements.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1901023","count":1},{"id":"GO:0006572","count":1},{"id":"GO:0006559","count":1},{"id":"GO:0019380","count":1},{"id":"GO:0019571","count":1}]},{"hash":"2203198897470775958","title":"Amino acid and cofactor biosynthesis","description":"The top GO terms point to biosynthetic pathways for several amino acids (histidine, phenylalanine, tyrosine) and cofactors (biotin, heme via protoporphyrinogen IX) as well as related catabolic/biosynthetic routes (kynurenine). This suggests a metabolic module focused on amino acid and cofactor production, with one outlier term (DNA-templated transcription) likely reflecting broader annotation noise. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0006533","count":1},{"id":"GO:0034276","count":1},{"id":"GO:0000105","count":1}]},{"hash":"2229729806477623091","title":"Unknown","description":"The top GO terms span a mix of stress-related cardiac signaling, inflammation regulation, meiosis, blood vessel branching, kinetochore localization, adenosine synthesis, DNA damage checkpoints, chromosome condensation, and lung epithelial differentiation. This diverse set provides no clear, single function or pathway tying the three proteins together, so a coherent cluster label cannot be assigned beyond Unknown.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1903244","count":3},{"id":"GO:0050728","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0010780","count":3},{"id":"GO:0001569","count":3}]},{"hash":"1365137234627594003","title":"Amino acid and central carbon metabolism","description":"Top GO terms center on amino acid metabolism (glutamate, glutamine, phenylalanine) and central carbon metabolism (TCA cycle), pointing to a metabolic cluster involved in amino acid and energy pathways. MoCo biosynthesis terms also align with enzymes requiring molybdenum cofactors in metabolism, strengthening the metabolic theme. A few receptor clustering terms likely reflect annotation noise. Thus, the cluster most plausibly represents amino acid and central carbon metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019552","count":1},{"id":"GO:0072350","count":1},{"id":"GO:0006537","count":1},{"id":"GO:0019551","count":1},{"id":"GO:0006541","count":1}]},{"hash":"787045691113791766","title":"Cajal body RNA localization and telomere maintenance","description":"The top terms cluster around Cajal body\u2013related RNA localization (scaRNA localization to Cajal body; protein localization to Cajal body) and telomere maintenance/telomerase activity, suggesting a nuclear RNA processing and telomere regulation theme. While inflammatory terms (IL-6 production) appear, they seem secondary to the core Cajal body and telomere biology signals, with possible ties to cell cycle context.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090666","count":2},{"id":"GO:0051973","count":2},{"id":"GO:2000778","count":2},{"id":"GO:0071866","count":2},{"id":"GO:0045041","count":2}]},{"hash":"1506489408544768878","title":"Nucleotide and sugar metabolism","description":"Top GO terms point to nucleotide salvage/biosynthesis and diverse sugar metabolism (sucrose/fructose responses, ribose catabolism, tagatose pathway). This suggests a metabolic module focused on nucleotide and carbohydrate metabolism rather than a single process.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":2},{"id":"GO:0006169","count":2},{"id":"GO:0006175","count":2},{"id":"GO:0009744","count":2},{"id":"GO:0009750","count":2}]},{"hash":"198412305455168896","title":"Vertebrate Embryonic Eye and Neural Crest Development","description":"The top GO terms point strongly to vertebrate embryogenesis, especially processes like optic cup morphogenesis and neural crest cell development, with supporting developmental patterning terms. While some metabolic terms appear, the most representative signal is embryonic development of the eye and neural crest, suggesting these proteins function in vertebrate developmental pathways rather than a single metabolic pathway.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009447","count":3},{"id":"GO:0006678","count":3},{"id":"GO:0010133","count":3},{"id":"GO:0048566","count":3},{"id":"GO:0002072","count":3}]},{"hash":"484658916426645659","title":"Nuclear RNA Splicing and Processing Machinery","description":"The top GO terms point to core nuclear RNA metabolism: spliceosome assembly and mRNA splicing, deadenylation-dependent decapping, tRNA processing, histone mRNA metabolism, rRNA maturation, and transcription termination, indicating a cohesive RNA processing/regulation cluster. The ABA and water deprivation signals suggest transcriptional regulation under stress, but the dominant theme is RNA processing and splicing machinery.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000290","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0000245","count":2},{"id":"GO:0008334","count":2},{"id":"GO:0030490","count":2}]},{"hash":"889684568852229898","title":"Neural development and intracellular transport","description":"The top terms strongly point to neural development (photoreceptor cell development, neural tube patterning) and learning, suggesting a neural function. The accompanying vesicle trafficking and organelle dynamics terms (ER-Golgi transport, Golgi-to-plasma membrane transport, mitochondrial fission, nuclear envelope organization) imply these proteins may also be involved in the cellular logistics that support neural cells. Together, they suggest a cluster of proteins linked to neural development with supporting roles in intracellular transport and organelle dynamics.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042461","count":1},{"id":"GO:0006623","count":1},{"id":"GO:0007612","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0021532","count":1}]},{"hash":"667323495565704293","title":"Unknown","description":"The cluster lists GO terms related to peroxisomal protein import (two terms) alongside DNA repair and replication processes (TLS, UV repair, DNA replication) and other broad processes like ubiquitination and cytokine response. There isn\u2019t a single, cohesive biological function that unites these terms for a small set of proteins, so a definitive, intuitive label cannot be confidently assigned.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016562","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0016558","count":2},{"id":"GO:0070987","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1343626718428876905","title":"Cytoplasmic Translation","description":"GO terms center on translation and cytoplasmic translational termination, suggesting the proteins are involved in cytosolic protein synthesis; the single glycosylation term is obsolete and not informative.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0002184","count":1}]},{"hash":"468050949839827353","title":"Unknown","description":"The top GO terms in this tiny cluster span diverse processes\u2014from TLR3 and PKC signaling to dopaminergic synaptic transmission, lipid metabolism, extracellular matrix remodeling, excretion, and even mitochondrial inheritance\u2014without a coherent unifying function. With only three proteins, there isn\u2019t a clear shared biological role to label, so the appropriate label is Unknown, with no confidence in a representative function.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0034141","count":3},{"id":"GO:0070528","count":3},{"id":"GO:0032226","count":3},{"id":"GO:0032933","count":3},{"id":"GO:0007588","count":3}]},{"hash":"665002982750103025","title":"Unknown","description":"The top GO terms span nitric oxide biosynthesis, mitochondrial inheritance, CNS myelin maintenance, sebaceous gland differentiation, unsaturated fatty acid and sterol (ergosterol) biosynthesis, sphingolipid metabolism, nitrate assimilation, peptide hormone response, and cysteine biosynthesis. This wide, seemingly unrelated mix provides no clear, cohesive function tying all three proteins together. ","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006809","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0006636","count":2}]},{"hash":"2047073456675940998","title":"Proteostasis under oxidative stress","description":"The cluster is dominated by GO terms related to chaperone-mediated assembly, protein quality control, and protein catabolic processes, all pointing to maintaining protein homeostasis under stress. Additional terms about peroxisomal import and organelle maintenance (mitochondrial DNA regulation) fit within the broader proteostasis/stress-response network. Together, these terms suggest a group of proteins involved in folding, quality control, and degradation in response to oxidative stress.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051131","count":1},{"id":"GO:0016558","count":1},{"id":"GO:0032463","count":1},{"id":"GO:0034599","count":1},{"id":"GO:0030163","count":1}]},{"hash":"1346612106718669128","title":"ER-Golgi protein trafficking and maturation","description":"The cluster is dominated by GO terms related to the secretory pathway: ER-to-Golgi vesicle transport, retrograde transport, general protein transport, and maturation/processing such as EGFR ligand maturation and membrane protein proteolysis. There are also signals of ER stress/unfolded protein response, which fit with protein maturation in the ER. A few developmental terms (wing/eye cell fate) may reflect tissue contexts where secretory trafficking is important, but the core theme ties to vesicle trafficking and maturation through the ER-Golgi axis.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035311","count":1},{"id":"GO:0048515","count":1},{"id":"GO:0038005","count":1},{"id":"GO:1904211","count":1},{"id":"GO:0042676","count":1}]},{"hash":"1652786142671518970","title":"Unknown","description":"There\u2019s no single cohesive function linking these GO terms: the set includes ubiquinone and tocopherol biosynthesis and regulation, lipid homeostasis, brain morphogenesis, and various stress/response processes. Without a clear overarching theme, an Unknown label with no confidence is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901006","count":1},{"id":"GO:1902171","count":1},{"id":"GO:0010795","count":1},{"id":"GO:0055088","count":1},{"id":"GO:0021692","count":1}]},{"hash":"1502808735355846381","title":"Mitochondrial Transport of Metabolites and Ions","description":"The top GO terms point strongly to transport across the mitochondrial membrane for a range of metabolites and cofactors (coenzyme A, ADP, NAD, thiamine pyrophosphate, phosphate, thiosulfate, iron) and even specific amino acid-related transport (ornithine), with additional terms linking to mitochondrial apoptotic processes and necroptotic regulation. This pattern suggests a cluster of proteins functioning as mitochondrial metabolite/ion transporters and related mitochondrial signaling components, rather than a single isolated function. ","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035349","count":2},{"id":"GO:0015866","count":2},{"id":"GO:0008637","count":2},{"id":"GO:0000066","count":2},{"id":"GO:0048250","count":2}]},{"hash":"757169649671967883","title":"Unknown","description":"The top GO terms are extremely heterogeneous, spanning nitric oxide biosynthesis, sebaceous gland differentiation, mitochondrial inheritance, unsaturated fatty acid and ergosterol-related lipid metabolism, fungal sphingolipid metabolism, nitrate assimilation, CNS myelin maintenance, chondrocyte development, and maltose transport, with no clear shared function. This wide spread suggests no cohesive biological role for the cluster, so assigning a concise functional label is not reliable.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006809","count":1},{"id":"GO:0001949","count":1},{"id":"GO:0000001","count":1},{"id":"GO:0006636","count":1},{"id":"GO:0032443","count":1}]},{"hash":"1858936443766893094","title":"Unknown","description":"The terms are highly diverse (developmental processes like gastrulation and neuron projection development; various metabolic and biosynthetic pathways; and several obsolete GO terms), with no clear shared function or pathway tying the proteins together. There are no edges or cohesive signals, so a coherent, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0016575","count":2},{"id":"GO:0007369","count":2}]},{"hash":"378339913865434760","title":"Seed dormancy","description":"The cluster's only shared GO annotation is embryo development ending in seed dormancy (GO:0009793), with one annotation among the three proteins. This points to a seed dormancy\u2013related function, so naming it Seed dormancy captures the core theme; however, the limited data (single term, no interactions) suggests moderate support for broader functional grouping.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009793","count":1}]}]