{"hash":"2237667266087992194","title":"S1P signaling in brain development and angiogenesis","description":"These terms cluster around sphingosine-1-phosphate signaling, including S1P receptor signaling and sphingosine biosynthesis, and extend to NF-kB\u2013 and TNF-related inflammatory signaling, calcium signaling, and processes linked to brain development, angiogenesis, and synaptic plasticity. The convergence on neurodevelopmental and vascular growth processes, together with NF-kB signaling, supports a coherent module centered on S1P-mediated signaling in brain and angiogenic contexts.","confidence":"High","size":11,"edges":12,"triangles":2,"max_degree":10,"top_function":null,"members":[{"accession":"XP_002500531.1","go_terms":[]},{"accession":"XP_002502241.1","go_terms":["GO:0030206","GO:0036066","GO:1990536","GO:0035436","GO:0036071","GO:0080147","GO:0015786","GO:0036085","GO:0015713","GO:0048527"]},{"accession":"XP_002507391.1","go_terms":["GO:2000182","GO:0030307","GO:0010803","GO:0010800","GO:1900452","GO:0045987","GO:0070493","GO:0001568","GO:0019722","GO:0045766","GO:0046834","GO:0046521","GO:0048146","GO:0032651","GO:0006648","GO:0006954","GO:0046339","GO:0007420","GO:0051092","GO:0003376","GO:0042346","GO:2000064","GO:0007205","GO:0046512","GO:0006671"]},{"accession":"XP_002502264.1","go_terms":["GO:0006855"]},{"accession":"XP_002509203.1","go_terms":["GO:2000182","GO:0030307","GO:0010803","GO:0010800","GO:1900452","GO:0045987","GO:0070493","GO:0001568","GO:0019722","GO:0045766","GO:0046834","GO:0046521","GO:0048146","GO:0032651","GO:0006648","GO:0006954","GO:0046339","GO:0007420","GO:0051092","GO:0003376","GO:0042346","GO:2000064","GO:0007205","GO:0046512","GO:0006671"]},{"accession":"XP_002503221.1","go_terms":[]},{"accession":"XP_002502955.1","go_terms":["GO:0006508","GO:0043171","GO:0046718","GO:0019885","GO:0003081","GO:0002003","GO:0002005","GO:0030154","GO:0002250","GO:0045766","GO:0006509","GO:0001525","GO:0007275","GO:0019370"]},{"accession":"XP_002504689.1","go_terms":["GO:0006508","GO:0043171","GO:0046718","GO:0019885","GO:0003081","GO:0002003","GO:0002005","GO:0030154","GO:0002250","GO:0045766","GO:0006509","GO:0001525","GO:0007275","GO:0019370"]},{"accession":"XP_002509173.1","go_terms":[]},{"accession":"XP_002500170.1","go_terms":[]},{"accession":"XP_002504063.1","go_terms":[]}],"graph":[["XP_002502955.1","XP_002509203.1",0.928],["XP_002504063.1","XP_002507391.1",0.529],["XP_002504063.1","XP_002509203.1",0.741],["XP_002500531.1","XP_002509203.1",0.66],["XP_002502241.1","XP_002503221.1",0.629],["XP_002502241.1","XP_002509203.1",0.866],["XP_002503221.1","XP_002509203.1",0.518],["XP_002500170.1","XP_002509203.1",0.682],["XP_002504689.1","XP_002509203.1",0.91],["XP_002502264.1","XP_002509203.1",0.826],["XP_002507391.1","XP_002509203.1",0.713],["XP_002509173.1","XP_002509203.1",0.548]],"all_go_terms":{"GO:0035436":1,"GO:0036085":1,"GO:0036066":1,"GO:0015713":1,"GO:0030206":1,"GO:1990536":1,"GO:0015786":1,"GO:0048527":1,"GO:0080147":1,"GO:0036071":1,"GO:0019722":2,"GO:0042346":2,"GO:0003376":2,"GO:0010803":2,"GO:0045766":4,"GO:0030307":2,"GO:0007420":2,"GO:0046512":2,"GO:1900452":2,"GO:0051092":2,"GO:0006954":2,"GO:0070493":2,"GO:2000182":2,"GO:0001568":2,"GO:0046834":2,"GO:0046521":2,"GO:0006648":2,"GO:0046339":2,"GO:0006671":2,"GO:0007205":2,"GO:0045987":2,"GO:0010800":2,"GO:2000064":2,"GO:0048146":2,"GO:0032651":2,"GO:0006855":1,"GO:0019370":2,"GO:0043171":2,"GO:0003081":2,"GO:0030154":2,"GO:0002250":2,"GO:0006508":2,"GO:0046718":2,"GO:0019885":2,"GO:0002005":2,"GO:0006509":2,"GO:0001525":2,"GO:0007275":2,"GO:0002003":2},"recipe_readded":[]}