{"hash":"940024161580335385","title":"Integrin-mediated adhesion and tissue development","description":"Central GO terms point to cell-matrix adhesion and integrin-mediated signaling as defining features of this cluster, with additional signals related to skin development, amelogenesis, trophoblast migration, and maintenance of organ identity. This pattern suggests a coherent theme of adhesion-driven communication guiding tissue formation and morphogenesis. Other terms like mitochondrial calcium homeostasis and sodium ion import are present but appear secondary to the adhesion\u2013signaling core.","confidence":"Medium","size":23,"edges":64,"triangles":21,"max_degree":8,"top_function":null,"members":[{"accession":"XP_019851112.1","go_terms":[]},{"accession":"XP_019852308.1","go_terms":[]},{"accession":"XP_019854748.1","go_terms":[]},{"accession":"XP_019859838.1","go_terms":[]},{"accession":"NP_001292176.1","go_terms":["GO:2000737","GO:0021514","GO:0034351","GO:0021510","GO:0044344","GO:1903672","GO:0003016","GO:0035265","GO:0002456","GO:0098773","GO:0003344","GO:0045602","GO:0097102","GO:0007451","GO:0060853","GO:0060855","GO:0060854","GO:0021693","GO:1990134","GO:0048839","GO:0061309","GO:0046331","GO:0001757","GO:0061156","GO:0003215","GO:0072554","GO:0070986","GO:0021688","GO:0060411","GO:0002043","GO:0035924","GO:0061073","GO:0060579","GO:0032495","GO:0003323","GO:0001569","GO:0003209","GO:0008407","GO:0048800","GO:0035912","GO:0061314","GO:0014807","GO:0014002","GO:0061074","GO:0097150","GO:0009954","GO:0090051","GO:0001974","GO:0003184","GO:0045639","GO:0035907","GO:1900746","GO:0048630","GO:0048633","GO:0060042","GO:0003222","GO:0072014","GO:0072015","GO:0072017","GO:0001947","GO:0045746","GO:0045747","GO:2000179","GO:0045662","GO:0061444","GO:0072006","GO:0045599","GO:0030718","GO:0045061","GO:0045669","GO:0030713","GO:0042492","GO:0042491","GO:0016330","GO:2000505","GO:0007275","GO:0072070","GO:0030720","GO:0045638","GO:0007386","GO:0007475","GO:0032693","GO:1903588","GO:0045608","GO:0048665","GO:0048190","GO:0008347","GO:0009912","GO:0036011","GO:0002315","GO:0045807","GO:0060841","GO:0016331","GO:0043055","GO:0042475"]},{"accession":"XP_003385989.1","go_terms":[]},{"accession":"XP_011406052.2","go_terms":["GO:0061450","GO:0021537","GO:0014819","GO:0007613","GO:0007160","GO:1990034","GO:0030501","GO:0051560","GO:0035994","GO:0035878","GO:0006883","GO:0043588","GO:0097186","GO:0006851","GO:0048333","GO:0031581","GO:0098703","GO:0048709","GO:0097094","GO:0048496","GO:0048172","GO:0007154","GO:0072001","GO:0003338","GO:0097369","GO:0060291","GO:0007229","GO:0098735"]},{"accession":"XP_019849265.1","go_terms":[]},{"accession":"XP_019850230.1","go_terms":["GO:0007362","GO:0035271","GO:0035143","GO:0001707","GO:0021919","GO:0061328","GO:0007313","GO:0001702","GO:0002053","GO:0030900","GO:0008293","GO:0030514","GO:0045668","GO:0001649"]},{"accession":"XP_019855028.1","go_terms":[]},{"accession":"XP_019855103.1","go_terms":[]},{"accession":"XP_019855456.1","go_terms":["GO:0001970","GO:0007597","GO:0010572","GO:0007160","GO:0043382","GO:0006924","GO:0045959","GO:0015979","GO:0001701","GO:0034392","GO:0045957","GO:0001867","GO:0006590","GO:0033623","GO:0001845","GO:0060244","GO:0033033","GO:0071625","GO:0046013","GO:0032613","GO:0060074","GO:0007157","GO:0006958","GO:0039573","GO:0090036","GO:0007338","GO:2001241","GO:0090050","GO:0051006","GO:0090528","GO:0050901","GO:0051918","GO:0002430","GO:0021680","GO:0006957"]},{"accession":"XP_019855785.1","go_terms":[]},{"accession":"XP_019855894.1","go_terms":["GO:0019226","GO:2000249","GO:0090080","GO:0021772","GO:0038162","GO:0002859","GO:0042517","GO:0001501","GO:0050927","GO:0036486","GO:0097067","GO:0030913","GO:0048672","GO:0035584","GO:1904597","GO:0045663","GO:0070640","GO:0021637","GO:0001759","GO:0002175","GO:0090272","GO:0060665","GO:0042523","GO:0021847","GO:0002371","GO:0043031","GO:0071205","GO:0021682","GO:0021785","GO:2000546","GO:0035397","GO:0035162","GO:2000830","GO:0010863","GO:0097491","GO:0097490","GO:0045058","GO:0042552","GO:0043303","GO:0046777","GO:0035855","GO:1903465","GO:0048378","GO:0060374","GO:0043318","GO:0032762","GO:0090197","GO:0035789","GO:0050712","GO:0043552","GO:0045162","GO:0038093","GO:0007224","GO:0050808","GO:0060117","GO:0002551","GO:2000660","GO:0001788","GO:1902287","GO:1900220","GO:0060445","GO:0035701","GO:0043931","GO:0035607","GO:0030318","GO:0035234","GO:0070306","GO:0048339","GO:0014068","GO:0045217","GO:0007037","GO:0007422","GO:0001798","GO:0097326","GO:0097324","GO:0000187","GO:0032516","GO:0050867","GO:1903045","GO:0050860","GO:0042590","GO:0038033","GO:0048070","GO:0001525","GO:0038109","GO:0042511","GO:0045765","GO:0001805","GO:0097350","GO:0002320","GO:0043069","GO:0002327","GO:2001200","GO:1904604","GO:0048661","GO:0038091","GO:1905065","GO:0050910","GO:0060484","GO:0007157","GO:0070486","GO:0086072","GO:1900016","GO:0042473","GO:0048691","GO:0071639","GO:0002318","GO:0010693","GO:0048675","GO:0021740","GO:0031175","GO:0021988","GO:0035018","GO:0007411","GO:0001886","GO:0002720","GO:0045425","GO:0045401","GO:0035157","GO:0001820","GO:2000661","GO:0071663","GO:0001923","GO:0097151","GO:2000391","GO:0090138","GO:0090673","GO:0030513","GO:0030101","GO:0072102","GO:0051092","GO:0007399","GO:0033004","GO:0001812","GO:2000566"]},{"accession":"XP_019857429.1","go_terms":[]},{"accession":"XP_019858117.1","go_terms":[]},{"accession":"XP_019858234.1","go_terms":[]},{"accession":"XP_011405693.1","go_terms":[]},{"accession":"XP_019854743.1","go_terms":[]},{"accession":"XP_019855612.1","go_terms":[]},{"accession":"XP_019860465.1","go_terms":[]},{"accession":"XP_019856039.1","go_terms":["GO:0061450","GO:0021537","GO:0014819","GO:0007613","GO:0007160","GO:1990034","GO:0030501","GO:0051560","GO:0035994","GO:0035878","GO:0006883","GO:0043588","GO:0097186","GO:0006851","GO:0048333","GO:0031581","GO:0098703","GO:0048709","GO:0097094","GO:0048496","GO:0048172","GO:0007154","GO:0072001","GO:0003338","GO:0097369","GO:0060291","GO:0007229","GO:0098735"]},{"accession":"XP_019851542.1","go_terms":[]}],"graph":[["XP_019858117.1","XP_003385989.1",0.961],["XP_019858117.1","XP_019849265.1",0.691],["XP_019858117.1","XP_019854743.1",0.716],["XP_019858117.1","XP_019854748.1",0.727],["XP_019858117.1","XP_019855612.1",0.852],["XP_019858117.1","XP_019858234.1",0.791],["XP_019854748.1","XP_011406052.2",0.739],["XP_019854748.1","XP_019850230.1",0.781],["XP_019854748.1","XP_019855456.1",0.786],["XP_019854748.1","XP_019855785.1",0.527],["XP_019854748.1","XP_019855894.1",0.529],["XP_019854748.1","XP_019858234.1",0.711],["XP_019857429.1","XP_019850230.1",0.831],["XP_019857429.1","XP_019856039.1",0.962],["XP_019857429.1","XP_019860465.1",0.688],["XP_019855103.1","XP_019850230.1",0.938],["XP_019855103.1","XP_019860465.1",0.761],["XP_019852308.1","NP_001292176.1",0.825],["XP_019852308.1","XP_011406052.2",0.772],["XP_019852308.1","XP_019849265.1",0.579],["XP_019852308.1","XP_019851112.1",0.6],["XP_019852308.1","XP_019855785.1",0.717],["XP_019852308.1","XP_019854743.1",0.925],["XP_019852308.1","XP_019855028.1",0.55],["XP_019854743.1","XP_019855456.1",0.756],["XP_019854743.1","XP_019855894.1",0.733],["XP_019856039.1","XP_011405693.1",0.964],["XP_019856039.1","XP_019851542.1",0.859],["XP_019856039.1","XP_019855785.1",0.912],["XP_019856039.1","XP_019858234.1",0.695],["XP_019856039.1","XP_019860465.1",0.837],["XP_019855785.1","XP_003385989.1",0.576],["XP_019855785.1","XP_011406052.2",0.504],["XP_019855785.1","XP_019851542.1",0.542],["XP_019855785.1","XP_019859838.1",0.607],["XP_019855785.1","XP_019860465.1",0.677],["XP_019855894.1","NP_001292176.1",0.961],["XP_019855894.1","XP_011405693.1",0.837],["XP_019855894.1","XP_019851542.1",0.746],["XP_019855894.1","XP_019855028.1",0.859],["XP_019855894.1","XP_019855612.1",0.735],["XP_003385989.1","NP_001292176.1",0.71],["XP_003385989.1","XP_011406052.2",0.907],["XP_003385989.1","XP_019849265.1",0.902],["XP_003385989.1","XP_019850230.1",0.747],["XP_003385989.1","XP_019858234.1",0.583],["XP_019851542.1","XP_011406052.2",0.939],["XP_019851542.1","XP_019851112.1",0.526],["XP_019851542.1","XP_019860465.1",0.678],["XP_019855612.1","XP_019855456.1",0.586],["XP_019855612.1","XP_019858234.1",0.803],["XP_019855612.1","XP_019860465.1",0.838],["XP_019858234.1","XP_019849265.1",0.581],["XP_019858234.1","XP_019850230.1",0.794],["XP_011406052.2","XP_011405693.1",0.94],["XP_011406052.2","XP_019855028.1",0.904],["XP_019859838.1","XP_011405693.1",0.962],["XP_019859838.1","XP_019849265.1",0.685],["XP_019859838.1","XP_019851112.1",0.717],["XP_019855028.1","XP_019850230.1",0.963],["XP_019855028.1","XP_019855456.1",0.629],["XP_019860465.1","XP_019850230.1",0.845],["XP_019860465.1","XP_019851112.1",0.657],["XP_019851112.1","XP_019855456.1",0.727]],"all_go_terms":{"GO:0060853":1,"GO:0035912":1,"GO:0060042":1,"GO:1990134":1,"GO:0007475":1,"GO:0098773":1,"GO:0048633":1,"GO:0009954":1,"GO:0045662":1,"GO:0045608":1,"GO:0021693":1,"GO:0001569":1,"GO:0046331":1,"GO:1900746":1,"GO:0014807":1,"GO:0045747":1,"GO:0045638":1,"GO:0021510":1,"GO:0070986":1,"GO:0045061":1,"GO:1903672":1,"GO:0072017":1,"GO:0072070":1,"GO:0060579":1,"GO:0042492":1,"GO:0007275":1,"GO:0061074":1,"GO:0097150":1,"GO:0003215":1,"GO:0034351":1,"GO:0048839":1,"GO:0060411":1,"GO:2000737":1,"GO:0003016":1,"GO:0021514":1,"GO:0035265":1,"GO:0044344":1,"GO:0016330":1,"GO:0090051":1,"GO:0003323":1,"GO:0072554":1,"GO:0043055":1,"GO:0030713":1,"GO:0035907":1,"GO:0045669":1,"GO:0002043":1,"GO:0003344":1,"GO:0045807":1,"GO:0072015":1,"GO:0045602":1,"GO:1903588":1,"GO:0061309":1,"GO:0061314":1,"GO:0048665":1,"GO:0060841":1,"GO:0009912":1,"GO:0008407":1,"GO:0002315":1,"GO:0048630":1,"GO:0016331":1,"GO:0045746":1,"GO:0001947":1,"GO:0001757":1,"GO:0035924":1,"GO:0003209":1,"GO:0007386":1,"GO:0001974":1,"GO:0032495":1,"GO:0036011":1,"GO:0061073":1,"GO:0072006":1,"GO:0060854":1,"GO:0060855":1,"GO:0030718":1,"GO:0007451":1,"GO:0048800":1,"GO:0042475":1,"GO:2000505":1,"GO:0030720":1,"GO:0003184":1,"GO:0032693":1,"GO:0048190":1,"GO:0021688":1,"GO:0003222":1,"GO:0008347":1,"GO:0014002":1,"GO:0097102":1,"GO:0045639":1,"GO:0061444":1,"GO:0045599":1,"GO:0002456":1,"GO:0061156":1,"GO:0072014":1,"GO:0042491":1,"GO:2000179":1,"GO:0007229":2,"GO:0051560":2,"GO:0097369":2,"GO:0097186":2,"GO:0061450":2,"GO:0048496":2,"GO:0007160":3,"GO:0043588":2,"GO:0007154":2,"GO:0048172":2,"GO:0072001":2,"GO:0003338":2,"GO:0031581":2,"GO:0030501":2,"GO:0097094":2,"GO:0021537":2,"GO:0007613":2,"GO:0006851":2,"GO:0048333":2,"GO:0014819":2,"GO:1990034":2,"GO:0035878":2,"GO:0060291":2,"GO:0098735":2,"GO:0035994":2,"GO:0048709":2,"GO:0006883":2,"GO:0098703":2,"GO:0035143":1,"GO:0061328":1,"GO:0001707":1,"GO:0030900":1,"GO:0045668":1,"GO:0007362":1,"GO:0007313":1,"GO:0021919":1,"GO:0001649":1,"GO:0035271":1,"GO:0008293":1,"GO:0002053":1,"GO:0030514":1,"GO:0001702":1,"GO:0006957":1,"GO:0001701":1,"GO:0007338":1,"GO:0006924":1,"GO:0001867":1,"GO:0006958":1,"GO:0045959":1,"GO:0051918":1,"GO:0090528":1,"GO:0034392":1,"GO:0006590":1,"GO:0046013":1,"GO:0060244":1,"GO:0071625":1,"GO:0033623":1,"GO:0045957":1,"GO:2001241":1,"GO:0043382":1,"GO:0039573":1,"GO:0033033":1,"GO:0060074":1,"GO:0001970":1,"GO:0032613":1,"GO:0002430":1,"GO:0007157":2,"GO:0050901":1,"GO:0007597":1,"GO:0021680":1,"GO:0051006":1,"GO:0090036":1,"GO:0001845":1,"GO:0010572":1,"GO:0090050":1,"GO:0015979":1,"GO:0045401":1,"GO:0097490":1,"GO:1905065":1,"GO:0035855":1,"GO:0097350":1,"GO:0097151":1,"GO:0001805":1,"GO:0090197":1,"GO:0045663":1,"GO:0035789":1,"GO:0007399":1,"GO:2001200":1,"GO:0010863":1,"GO:0031175":1,"GO:0021682":1,"GO:0071205":1,"GO:0070306":1,"GO:0010693":1,"GO:0048339":1,"GO:0050927":1,"GO:0072102":1,"GO:0032762":1,"GO:0090080":1,"GO:0035584":1,"GO:0035701":1,"GO:0048691":1,"GO:0090272":1,"GO:1900016":1,"GO:0060484":1,"GO:1903465":1,"GO:0035234":1,"GO:2000660":1,"GO:0021847":1,"GO:0050712":1,"GO:0097326":1,"GO:2000830":1,"GO:0002551":1,"GO:1900220":1,"GO:0002720":1,"GO:0043318":1,"GO:0036486":1,"GO:1903045":1,"GO:0042517":1,"GO:0000187":1,"GO:0042473":1,"GO:0050867":1,"GO:0035162":1,"GO:0042552":1,"GO:0045765":1,"GO:0014068":1,"GO:0048672":1,"GO:0007037":1,"GO:0001886":1,"GO:0038093":1,"GO:0021772":1,"GO:0048070":1,"GO:0048675":1,"GO:0001788":1,"GO:0030318":1,"GO:0048378":1,"GO:0045058":1,"GO:0019226":1,"GO:0050910":1,"GO:0001759":1,"GO:0038109":1,"GO:0042590":1,"GO:2000661":1,"GO:0035397":1,"GO:0046777":1,"GO:0060665":1,"GO:0050860":1,"GO:0002371":1,"GO:0002318":1,"GO:0035018":1,"GO:0002175":1,"GO:0045217":1,"GO:0001812":1,"GO:0030513":1,"GO:0043069":1,"GO:0090138":1,"GO:0043303":1,"GO:0042511":1,"GO:1902287":1,"GO:0043031":1,"GO:0060117":1,"GO:0060374":1,"GO:0045162":1,"GO:0086072":1,"GO:0001501":1,"GO:0002320":1,"GO:0050808":1,"GO:0042523":1,"GO:0021740":1,"GO:0002859":1,"GO:0001798":1,"GO:0051092":1,"GO:2000566":1,"GO:0060445":1,"GO:0007422":1,"GO:0097491":1,"GO:0043552":1,"GO:1904597":1,"GO:0001525":1,"GO:0030913":1,"GO:0071639":1,"GO:0038162":1,"GO:0071663":1,"GO:0033004":1,"GO:0002327":1,"GO:0035607":1,"GO:2000391":1,"GO:0001820":1,"GO:0001923":1,"GO:0045425":1,"GO:0035157":1,"GO:0030101":1,"GO:0070486":1,"GO:0007411":1,"GO:0038091":1,"GO:0038033":1,"GO:0090673":1,"GO:0021637":1,"GO:0097324":1,"GO:0048661":1,"GO:0007224":1,"GO:0097067":1,"GO:1904604":1,"GO:2000546":1,"GO:0021988":1,"GO:2000249":1,"GO:0032516":1,"GO:0021785":1,"GO:0043931":1,"GO:0070640":1},"recipe_readded":[]}