{"hash":"982720682745956538","title":"APC/C-Mediated Mitosis and K11 Ubiquitination","description":"The top GO terms cluster around mitotic progression and ubiquitin-dependent proteolysis, notably mitotic cell cycle, cell division, and the metaphase/anaphase transition, with K11-linked ubiquitination strongly indicating APC/C-driven substrate degradation. This combination points to proteins that regulate mitosis via ubiquitin tagging and degradation. While a few terms relate to DNA repair or histone mRNA turnover, they do not override the dominant mitotic-ubiquitin theme. Overall, this label captures the core function of the cluster.","confidence":"High","size":17,"edges":129,"triangles":586,"max_degree":16,"top_function":"mitotic cell cycle","members":[{"accession":"XP_629168.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0000492","GO:0008653","GO:0007346","GO:0071908","GO:0071492","GO:0045070","GO:0071909","GO:0003283","GO:0051661","GO:0008277","GO:0072189","GO:0046890","GO:0048496","GO:0050714","GO:0051348","GO:0006986","GO:0000278","GO:0051301","GO:0006478","GO:0045842","GO:0050689","GO:0070979","GO:0016570","GO:2001162","GO:0035457","GO:0045087","GO:1903071","GO:0031145","GO:1903546","GO:0036494","GO:0090526","GO:0051607","GO:0071360","GO:1902391","GO:1905515","GO:0007091","GO:2000324","GO:0015979","GO:0000413","GO:0009736","GO:0035955","GO:0016576","GO:1903646","GO:1902325","GO:1903070","GO:0010288","GO:0070301","GO:0051291","GO:2000531","GO:0071276","GO:0043278","GO:1901215","GO:0031400","GO:0009938"]},{"accession":"XP_636847.1","go_terms":["GO:0072443","GO:0034502","GO:1904515","GO:1904263","GO:0007004"]},{"accession":"XP_638280.1","go_terms":["GO:0031081","GO:0006606","GO:0030032","GO:2000331","GO:0000055","GO:0048246","GO:0006406"]},{"accession":"XP_640814.1","go_terms":["GO:0071044","GO:0055012","GO:0071481","GO:0006471","GO:0060065","GO:0003257","GO:0010667","GO:0060157","GO:0003231","GO:2001015","GO:0000723","GO:0001560","GO:0042275","GO:0071475","GO:0060008","GO:1990683","GO:1900222","GO:1904706","GO:2000721","GO:2000727","GO:0032508","GO:0051152","GO:0010832","GO:0031047","GO:0016049","GO:0030263","GO:0016925","GO:0030511","GO:0032208","GO:1900239","GO:0035886","GO:0007420","GO:0097070","GO:0045657","GO:0010735","GO:1904753","GO:2000587","GO:0097680"]},{"accession":"XP_640916.1","go_terms":[]},{"accession":"XP_641250.1","go_terms":["GO:0070979","GO:0000278","GO:0031145","GO:0051301"]},{"accession":"XP_643175.1","go_terms":[]},{"accession":"XP_643183.1","go_terms":["GO:0000278","GO:0030154","GO:0031145","GO:0090129","GO:0051301","GO:0050775","GO:0007399","GO:0070979","GO:0009561","GO:0045773","GO:0031915","GO:0042787","GO:0007091"]},{"accession":"XP_644109.1","go_terms":["GO:1990451","GO:0071264","GO:0031953","GO:1990497","GO:0060733","GO:0097201","GO:0070301","GO:1902073","GO:0033235","GO:0071494","GO:0072755","GO:1990253","GO:1990138","GO:0071232","GO:0031333","GO:1903833","GO:0042149","GO:0036492","GO:0060765","GO:1904803","GO:0000077","GO:1901487","GO:0032020","GO:0042138","GO:0010390","GO:0043951","GO:0090089","GO:0030509","GO:0043524","GO:0051569","GO:0031058","GO:0070936","GO:0006303","GO:0000086","GO:0035666","GO:0070534","GO:0043123","GO:1903955","GO:0010976","GO:0007288","GO:0031505","GO:0070423","GO:0070987","GO:0051865","GO:0016562","GO:0031497","GO:0051026","GO:0070911","GO:1902426","GO:0010620","GO:1990920","GO:0045116","GO:0031571","GO:0070459","GO:0071455","GO:0071596","GO:0033128","GO:0006348","GO:0007059","GO:0042276","GO:0038095","GO:0070193","GO:1901694","GO:0051443","GO:0071347","GO:0016558","GO:0085020","GO:0051965","GO:0045739","GO:0030466","GO:0031939","GO:0010845","GO:0006344","GO:0000722","GO:0007254","GO:0001701","GO:0042275","GO:0000724","GO:0070979","GO:0000729","GO:0060340","GO:1902916","GO:1904153","GO:1901044","GO:0010994","GO:0002223","GO:0031146","GO:0031145","GO:0045141","GO:0051092","GO:0044314","GO:0070076","GO:0070059","GO:0061186","GO:0071894","GO:0035519","GO:1903755","GO:0035458","GO:0000022","GO:0051301","GO:0009737","GO:0071629","GO:0050852","GO:0000278","GO:0006915","GO:0030433","GO:0033182","GO:0010458","GO:0016032"]},{"accession":"XP_644589.1","go_terms":["GO:0090326","GO:0007040","GO:0050882","GO:0043653","GO:0090141","GO:0045056","GO:0061357","GO:1904647","GO:1903828","GO:1902950","GO:0099639","GO:2000331","GO:1905166","GO:0060161","GO:0042147","GO:0099074","GO:0031648","GO:1902823","GO:1903181","GO:0045053","GO:0090263","GO:0032463"]},{"accession":"XP_644922.1","go_terms":[]},{"accession":"XP_645162.1","go_terms":[]},{"accession":"XP_645586.2","go_terms":["GO:0071044","GO:0071028","GO:0071040","GO:0071048","GO:0071049","GO:0071051","GO:0009048","GO:0071042","GO:0080188","GO:0033621","GO:0034475","GO:0034476","GO:0071037","GO:0071036","GO:0071035","GO:0034473","GO:0071039","GO:0071038","GO:0000460","GO:1902466","GO:0000467","GO:0000973","GO:0032066","GO:0098530","GO:0009432","GO:0061820","GO:0040009","GO:0042780","GO:0006260","GO:1903221","GO:0072757","GO:0006281","GO:0072711","GO:0044806","GO:0006310","GO:0090503","GO:0000732","GO:1901291","GO:0033259","GO:0045950"]},{"accession":"XP_645628.1","go_terms":["GO:0000289","GO:0010606","GO:0006397","GO:0034729","GO:0000245","GO:0048149","GO:1990108","GO:0071108","GO:0021551","GO:0051568","GO:0001662","GO:0035871","GO:0008583","GO:1904667","GO:0010995","GO:0070537","GO:0010992","GO:1904378","GO:0060013","GO:1903070","GO:0035520","GO:0035523","GO:0008343","GO:0044313","GO:1900425","GO:1901026","GO:0035192","GO:0006355","GO:0006511","GO:0006351","GO:0035616"]},{"accession":"XP_645682.1","go_terms":[]},{"accession":"XP_646255.1","go_terms":[]},{"accession":"XP_647212.1","go_terms":["GO:0035518","GO:0031286","GO:0000086","GO:0048825","GO:0030154","GO:0000082","GO:0007295","GO:0051759","GO:2000819","GO:0044346","GO:0010100","GO:0001701","GO:0070979","GO:0048575","GO:0051232","GO:1903467","GO:0030853","GO:0042787","GO:0043149","GO:0000278","GO:0008283","GO:0031146","GO:0035019","GO:0050775","GO:0072576","GO:0007399","GO:0040016","GO:0001831","GO:0045773","GO:0031915","GO:1902104","GO:2000001","GO:0030097","GO:1900087","GO:0006355","GO:0006351","GO:0006367","GO:0035024","GO:0019102","GO:0009640","GO:0017145"]}],"graph":[["XP_643175.1","XP_629168.1",0.667],["XP_643175.1","XP_636847.1",0.678],["XP_643175.1","XP_638280.1",0.585],["XP_643175.1","XP_640814.1",0.652],["XP_643175.1","XP_640916.1",0.591],["XP_643175.1","XP_641250.1",0.737],["XP_643175.1","XP_647212.1",0.58],["XP_643175.1","XP_646255.1",0.605],["XP_643175.1","XP_645162.1",0.622],["XP_643175.1","XP_645586.2",0.685],["XP_643175.1","XP_645628.1",0.619],["XP_643175.1","XP_645682.1",0.68],["XP_643175.1","XP_644109.1",0.672],["XP_643175.1","XP_644589.1",0.656],["XP_643175.1","XP_644922.1",0.628],["XP_643175.1","XP_643183.1",0.531],["XP_645586.2","XP_629168.1",0.702],["XP_645586.2","XP_636847.1",0.622],["XP_645586.2","XP_638280.1",0.701],["XP_645586.2","XP_640814.1",0.706],["XP_645586.2","XP_640916.1",0.695],["XP_645586.2","XP_641250.1",0.721],["XP_645586.2","XP_643183.1",0.678],["XP_645586.2","XP_644109.1",0.681],["XP_645586.2","XP_644589.1",0.697],["XP_645586.2","XP_644922.1",0.684],["XP_645586.2","XP_645162.1",0.615],["XP_645586.2","XP_645628.1",0.674],["XP_645586.2","XP_645682.1",0.646],["XP_645586.2","XP_646255.1",0.631],["XP_645586.2","XP_647212.1",0.695],["XP_645682.1","XP_629168.1",0.691],["XP_645682.1","XP_636847.1",0.682],["XP_645682.1","XP_638280.1",0.658],["XP_645682.1","XP_640814.1",0.688],["XP_645682.1","XP_640916.1",0.633],["XP_645682.1","XP_641250.1",0.734],["XP_645682.1","XP_643183.1",0.589],["XP_645682.1","XP_644109.1",0.66],["XP_645682.1","XP_644589.1",0.688],["XP_645682.1","XP_644922.1",0.676],["XP_645682.1","XP_645162.1",0.637],["XP_645682.1","XP_645628.1",0.652],["XP_645682.1","XP_646255.1",0.642],["XP_645682.1","XP_647212.1",0.633],["XP_638280.1","XP_629168.1",0.641],["XP_638280.1","XP_636847.1",0.673],["XP_638280.1","XP_640814.1",0.626],["XP_638280.1","XP_640916.1",0.557],["XP_638280.1","XP_641250.1",0.713],["XP_638280.1","XP_643183.1",0.541],["XP_638280.1","XP_644109.1",0.694],["XP_638280.1","XP_644589.1",0.626],["XP_638280.1","XP_644922.1",0.637],["XP_638280.1","XP_645162.1",0.566],["XP_638280.1","XP_645628.1",0.618],["XP_638280.1","XP_646255.1",0.579],["XP_638280.1","XP_647212.1",0.538],["XP_647212.1","XP_629168.1",0.625],["XP_647212.1","XP_636847.1",0.659],["XP_647212.1","XP_640814.1",0.625],["XP_647212.1","XP_640916.1",0.585],["XP_647212.1","XP_641250.1",0.715],["XP_647212.1","XP_644109.1",0.704],["XP_647212.1","XP_644589.1",0.63],["XP_647212.1","XP_644922.1",0.631],["XP_647212.1","XP_645162.1",0.574],["XP_647212.1","XP_645628.1",0.595],["XP_647212.1","XP_646255.1",0.578],["XP_643183.1","XP_629168.1",0.628],["XP_643183.1","XP_636847.1",0.571],["XP_643183.1","XP_640814.1",0.578],["XP_643183.1","XP_640916.1",0.504],["XP_643183.1","XP_641250.1",0.693],["XP_643183.1","XP_644109.1",0.66],["XP_643183.1","XP_644589.1",0.619],["XP_643183.1","XP_644922.1",0.544],["XP_645162.1","XP_629168.1",0.671],["XP_645162.1","XP_636847.1",0.641],["XP_645162.1","XP_640814.1",0.561],["XP_645162.1","XP_641250.1",0.74],["XP_645162.1","XP_644109.1",0.714],["XP_645162.1","XP_644589.1",0.654],["XP_645162.1","XP_644922.1",0.59],["XP_645162.1","XP_645628.1",0.601],["XP_644922.1","XP_629168.1",0.694],["XP_644922.1","XP_636847.1",0.661],["XP_644922.1","XP_640814.1",0.654],["XP_644922.1","XP_640916.1",0.578],["XP_644922.1","XP_641250.1",0.726],["XP_644922.1","XP_646255.1",0.6],["XP_644922.1","XP_644109.1",0.69],["XP_644922.1","XP_644589.1",0.667],["XP_644922.1","XP_645628.1",0.612],["XP_640814.1","XP_629168.1",0.72],["XP_640814.1","XP_636847.1",0.696],["XP_640814.1","XP_640916.1",0.533],["XP_640814.1","XP_641250.1",0.752],["XP_640814.1","XP_644109.1",0.72],["XP_640814.1","XP_644589.1",0.7],["XP_640814.1","XP_645628.1",0.672],["XP_640814.1","XP_646255.1",0.581],["XP_644109.1","XP_629168.1",0.69],["XP_644109.1","XP_636847.1",0.662],["XP_644109.1","XP_640916.1",0.696],["XP_644109.1","XP_641250.1",0.704],["XP_644109.1","XP_646255.1",0.702],["XP_644109.1","XP_644589.1",0.684],["XP_644109.1","XP_645628.1",0.693],["XP_645628.1","XP_629168.1",0.68],["XP_645628.1","XP_636847.1",0.635],["XP_645628.1","XP_640916.1",0.614],["XP_645628.1","XP_641250.1",0.703],["XP_645628.1","XP_644589.1",0.664],["XP_645628.1","XP_646255.1",0.584],["XP_644589.1","XP_629168.1",0.681],["XP_644589.1","XP_636847.1",0.688],["XP_644589.1","XP_640916.1",0.661],["XP_644589.1","XP_641250.1",0.735],["XP_644589.1","XP_646255.1",0.67],["XP_646255.1","XP_629168.1",0.679],["XP_646255.1","XP_636847.1",0.641],["XP_646255.1","XP_641250.1",0.726],["XP_641250.1","XP_629168.1",0.733],["XP_641250.1","XP_636847.1",0.718],["XP_641250.1","XP_640916.1",0.731],["XP_629168.1","XP_636847.1",0.709],["XP_629168.1","XP_640916.1",0.675],["XP_636847.1","XP_640916.1",0.661]],"all_go_terms":{"GO:0072189":1,"GO:1902325":1,"GO:0007346":1,"GO:2000324":1,"GO:0046890":1,"GO:1903071":1,"GO:0045087":1,"GO:0045842":1,"GO:0035955":1,"GO:0030850":1,"GO:0006463":1,"GO:0070979":5,"GO:2000531":1,"GO:0051301":4,"GO:0006478":1,"GO:2001162":1,"GO:0006986":1,"GO:0008277":1,"GO:0009736":1,"GO:0031400":1,"GO:0000492":1,"GO:0046661":1,"GO:0050689":1,"GO:0070301":2,"GO:0051607":1,"GO:0016570":1,"GO:0009938":1,"GO:0051661":1,"GO:0071276":1,"GO:0035457":1,"GO:0036494":1,"GO:0071492":1,"GO:0031145":4,"GO:1903546":1,"GO:1902391":1,"GO:1901215":1,"GO:0007091":2,"GO:1903646":1,"GO:0045070":1,"GO:0071357":1,"GO:0000278":5,"GO:1905515":1,"GO:0071908":1,"GO:0010288":1,"GO:1903070":2,"GO:0071360":1,"GO:0016576":1,"GO:0000413":1,"GO:0051291":1,"GO:0071909":1,"GO:0048496":1,"GO:0008653":1,"GO:0003283":1,"GO:0015979":1,"GO:0043278":1,"GO:0051348":1,"GO:0090526":1,"GO:0050714":1,"GO:1904515":1,"GO:1904263":1,"GO:0007004":1,"GO:0072443":1,"GO:0034502":1,"GO:0048246":1,"GO:0030032":1,"GO:0031081":1,"GO:0006406":1,"GO:0000055":1,"GO:2000331":2,"GO:0006606":1,"GO:0016049":1,"GO:0016925":1,"GO:1904706":1,"GO:0042275":2,"GO:0071044":2,"GO:2000727":1,"GO:1904753":1,"GO:0001560":1,"GO:0071481":1,"GO:1900222":1,"GO:0000723":1,"GO:2001015":1,"GO:0055012":1,"GO:0071475":1,"GO:2000721":1,"GO:0010832":1,"GO:0030263":1,"GO:1990683":1,"GO:0097680":1,"GO:0060157":1,"GO:0031047":1,"GO:0045657":1,"GO:0060008":1,"GO:0051152":1,"GO:0032508":1,"GO:0030511":1,"GO:2000587":1,"GO:0097070":1,"GO:0032208":1,"GO:0003257":1,"GO:0010667":1,"GO:0003231":1,"GO:0007420":1,"GO:1900239":1,"GO:0035886":1,"GO:0060065":1,"GO:0006471":1,"GO:0010735":1,"GO:0031915":2,"GO:0042787":2,"GO:0090129":1,"GO:0009561":1,"GO:0045773":2,"GO:0007399":2,"GO:0050775":2,"GO:0030154":2,"GO:0060340":1,"GO:0051092":1,"GO:0051443":1,"GO:0032020":1,"GO:0071264":1,"GO:0006344":1,"GO:0016558":1,"GO:1990138":1,"GO:1904803":1,"GO:0006915":1,"GO:1903833":1,"GO:0016032":1,"GO:0090089":1,"GO:0045739":1,"GO:0035666":1,"GO:0033182":1,"GO:0085020":1,"GO:0051865":1,"GO:0031953":1,"GO:0070534":1,"GO:0031505":1,"GO:0031497":1,"GO:0071232":1,"GO:0010994":1,"GO:1902426":1,"GO:0071596":1,"GO:0070059":1,"GO:0045141":1,"GO:0036492":1,"GO:1902073":1,"GO:0060765":1,"GO:0070459":1,"GO:1902916":1,"GO:0000724":1,"GO:0051026":1,"GO:0010390":1,"GO:1990497":1,"GO:0042149":1,"GO:0072755":1,"GO:0010976":1,"GO:0070423":1,"GO:0030433":1,"GO:0010845":1,"GO:0035519":1,"GO:0043951":1,"GO:0000022":1,"GO:0071347":1,"GO:1901694":1,"GO:0043123":1,"GO:1903755":1,"GO:1901044":1,"GO:0042138":1,"GO:1904153":1,"GO:0009737":1,"GO:0071455":1,"GO:0050852":1,"GO:0033235":1,"GO:0031058":1,"GO:0071629":1,"GO:0031571":1,"GO:1990451":1,"GO:0044314":1,"GO:0000729":1,"GO:0006348":1,"GO:0010458":1,"GO:0007059":1,"GO:0030466":1,"GO:0031146":2,"GO:0031333":1,"GO:0070076":1,"GO:0006303":1,"GO:0070911":1,"GO:1990920":1,"GO:0007288":1,"GO:0051965":1,"GO:0071494":1,"GO:0051569":1,"GO:0000722":1,"GO:0097201":1,"GO:1990253":1,"GO:0038095":1,"GO:0070936":1,"GO:0070987":1,"GO:0042276":1,"GO:0016562":1,"GO:0000086":2,"GO:0033128":1,"GO:0007254":1,"GO:0035458":1,"GO:0060733":1,"GO:0031939":1,"GO:1901487":1,"GO:0002223":1,"GO:0000077":1,"GO:0045116":1,"GO:1903955":1,"GO:0071894":1,"GO:0070193":1,"GO:0030509":1,"GO:0010620":1,"GO:0001701":2,"GO:0043524":1,"GO:0061186":1,"GO:0060161":1,"GO:0061357":1,"GO:0031648":1,"GO:0042147":1,"GO:0045053":1,"GO:1903828":1,"GO:0050882":1,"GO:0099639":1,"GO:0007040":1,"GO:1902950":1,"GO:0099074":1,"GO:0090263":1,"GO:0032463":1,"GO:0043653":1,"GO:1905166":1,"GO:1904647":1,"GO:0090326":1,"GO:0045056":1,"GO:1902823":1,"GO:1903181":1,"GO:0090141":1,"GO:0009432":1,"GO:0071048":1,"GO:0071036":1,"GO:0040009":1,"GO:0033259":1,"GO:0071037":1,"GO:0006310":1,"GO:0071049":1,"GO:0098530":1,"GO:0000460":1,"GO:0071051":1,"GO:0072757":1,"GO:0071039":1,"GO:0072711":1,"GO:1901291":1,"GO:0000973":1,"GO:0071042":1,"GO:0000732":1,"GO:0071038":1,"GO:0071028":1,"GO:0033621":1,"GO:0006281":1,"GO:0006260":1,"GO:0045950":1,"GO:0034476":1,"GO:1902466":1,"GO:0034473":1,"GO:0032066":1,"GO:0034475":1,"GO:0061820":1,"GO:0000467":1,"GO:0071040":1,"GO:0071035":1,"GO:1903221":1,"GO:0044806":1,"GO:0090503":1,"GO:0080188":1,"GO:0009048":1,"GO:0042780":1,"GO:0006351":2,"GO:1904667":1,"GO:0006511":1,"GO:0035520":1,"GO:1990108":1,"GO:0035871":1,"GO:0060013":1,"GO:0006397":1,"GO:0010606":1,"GO:0000245":1,"GO:1904378":1,"GO:0006355":2,"GO:1901026":1,"GO:0000289":1,"GO:0048149":1,"GO:0021551":1,"GO:0035616":1,"GO:0071108":1,"GO:0008343":1,"GO:1900425":1,"GO:0051568":1,"GO:0010995":1,"GO:0008583":1,"GO:0035523":1,"GO:0001662":1,"GO:0044313":1,"GO:0070537":1,"GO:0035192":1,"GO:0034729":1,"GO:0010992":1,"GO:0001831":1,"GO:0019102":1,"GO:0044346":1,"GO:2000819":1,"GO:0030853":1,"GO:0030097":1,"GO:1903467":1,"GO:0035518":1,"GO:2000001":1,"GO:0007295":1,"GO:0009640":1,"GO:0043149":1,"GO:0035024":1,"GO:0035019":1,"GO:1900087":1,"GO:0010100":1,"GO:0048825":1,"GO:0017145":1,"GO:0031286":1,"GO:0048575":1,"GO:0051232":1,"GO:0000082":1,"GO:0072576":1,"GO:1902104":1,"GO:0051759":1,"GO:0040016":1,"GO:0008283":1,"GO:0006367":1},"recipe_readded":[]}