{"hash":"697386826095914547","title":"Insulin signaling and glucose uptake regulation","description":"The cluster\u2019s top GO terms center on insulin receptor internalization and negative regulation of insulin receptor signaling and PI3K/AKT signaling, along with negative regulation of glucose import, pointing to modulation of insulin signaling and glucose uptake. Other terms (GPI anchor biosynthesis, autophagosome assembly, ER protein folding) appear ancillary, but the dominant theme is insulin pathway regulation affecting glucose handling.","confidence":"High","size":16,"edges":109,"triangles":423,"max_degree":15,"top_function":null,"members":[{"accession":"XP_637931.1","go_terms":[]},{"accession":"XP_001134593.1","go_terms":["GO:0006506"]},{"accession":"XP_637338.1","go_terms":[]},{"accession":"XP_638310.1","go_terms":[]},{"accession":"XP_645279.1","go_terms":[]},{"accession":"XP_001134562.1","go_terms":["GO:0034975","GO:0000045"]},{"accession":"XP_629046.1","go_terms":["GO:0042733","GO:0038016","GO:0046627","GO:0051898","GO:0046325"]},{"accession":"XP_638976.2","go_terms":["GO:0042733","GO:0038016","GO:0046627","GO:0051898","GO:0046325"]},{"accession":"XP_640682.1","go_terms":[]},{"accession":"XP_645113.1","go_terms":[]},{"accession":"XP_644530.1","go_terms":[]},{"accession":"NP_050086.1","go_terms":["GO:0042777","GO:0099132"]},{"accession":"XP_647204.1","go_terms":[]},{"accession":"XP_640190.1","go_terms":[]},{"accession":"XP_640859.2","go_terms":["GO:0032979","GO:0015031"]},{"accession":"XP_642452.1","go_terms":[]}],"graph":[["XP_642452.1","NP_050086.1",0.632],["XP_642452.1","XP_001134593.1",0.625],["XP_642452.1","XP_629046.1",0.786],["XP_642452.1","XP_637338.1",0.605],["XP_642452.1","XP_638310.1",0.724],["XP_642452.1","XP_638976.2",0.789],["XP_642452.1","XP_640682.1",0.77],["XP_642452.1","XP_640859.2",0.605],["XP_642452.1","XP_645113.1",0.758],["XP_642452.1","XP_645279.1",0.696],["XP_642452.1","XP_647204.1",0.663],["XP_629046.1","NP_050086.1",0.749],["XP_629046.1","XP_001134562.1",0.734],["XP_629046.1","XP_001134593.1",0.74],["XP_629046.1","XP_640190.1",0.779],["XP_629046.1","XP_638976.2",0.774],["XP_629046.1","XP_638310.1",0.736],["XP_629046.1","XP_637931.1",0.691],["XP_629046.1","XP_637338.1",0.849],["XP_629046.1","XP_647204.1",0.804],["XP_629046.1","XP_645113.1",0.761],["XP_629046.1","XP_645279.1",0.737],["XP_629046.1","XP_644530.1",0.734],["XP_629046.1","XP_640682.1",0.78],["XP_629046.1","XP_640859.2",0.758],["XP_001134593.1","XP_001134562.1",0.587],["XP_001134593.1","XP_637338.1",0.825],["XP_001134593.1","XP_637931.1",0.697],["XP_001134593.1","XP_638310.1",0.642],["XP_001134593.1","XP_638976.2",0.622],["XP_001134593.1","XP_640190.1",0.663],["XP_001134593.1","XP_640682.1",0.683],["XP_001134593.1","XP_640859.2",0.625],["XP_001134593.1","XP_645113.1",0.779],["XP_001134593.1","XP_645279.1",0.546],["XP_001134593.1","XP_647204.1",0.723],["XP_640190.1","NP_050086.1",0.612],["XP_640190.1","XP_001134562.1",0.64],["XP_640190.1","XP_637338.1",0.805],["XP_640190.1","XP_638310.1",0.81],["XP_640190.1","XP_638976.2",0.689],["XP_640190.1","XP_640682.1",0.73],["XP_640190.1","XP_640859.2",0.761],["XP_640190.1","XP_644530.1",0.685],["XP_640190.1","XP_645113.1",0.509],["XP_640190.1","XP_645279.1",0.783],["XP_644530.1","NP_050086.1",0.525],["XP_644530.1","XP_637338.1",0.751],["XP_644530.1","XP_637931.1",0.666],["XP_644530.1","XP_638310.1",0.668],["XP_644530.1","XP_638976.2",0.713],["XP_644530.1","XP_640682.1",0.664],["XP_644530.1","XP_640859.2",0.614],["XP_644530.1","XP_645113.1",0.585],["XP_644530.1","XP_645279.1",0.527],["XP_640682.1","NP_050086.1",0.778],["XP_640682.1","XP_001134562.1",0.784],["XP_640682.1","XP_637338.1",0.685],["XP_640682.1","XP_637931.1",0.739],["XP_640682.1","XP_638310.1",0.726],["XP_640682.1","XP_638976.2",0.78],["XP_640682.1","XP_640859.2",0.742],["XP_640682.1","XP_645113.1",0.844],["XP_640682.1","XP_645279.1",0.613],["XP_640682.1","XP_647204.1",0.775],["XP_638976.2","NP_050086.1",0.707],["XP_638976.2","XP_001134562.1",0.69],["XP_638976.2","XP_637338.1",0.796],["XP_638976.2","XP_637931.1",0.64],["XP_638976.2","XP_638310.1",0.695],["XP_638976.2","XP_647204.1",0.731],["XP_638976.2","XP_645113.1",0.744],["XP_638976.2","XP_645279.1",0.751],["XP_638976.2","XP_640859.2",0.687],["XP_001134562.1","NP_050086.1",0.561],["XP_001134562.1","XP_637338.1",0.739],["XP_001134562.1","XP_637931.1",0.634],["XP_001134562.1","XP_638310.1",0.668],["XP_001134562.1","XP_640859.2",0.523],["XP_001134562.1","XP_645113.1",0.815],["XP_001134562.1","XP_645279.1",0.776],["XP_001134562.1","XP_647204.1",0.71],["XP_637338.1","NP_050086.1",0.782],["XP_637338.1","XP_638310.1",0.677],["XP_637338.1","XP_637931.1",0.703],["XP_637338.1","XP_640859.2",0.844],["XP_637338.1","XP_645113.1",0.699],["XP_637338.1","XP_645279.1",0.683],["XP_637338.1","XP_647204.1",0.814],["XP_645279.1","NP_050086.1",0.653],["XP_645279.1","XP_637931.1",0.74],["XP_645279.1","XP_638310.1",0.63],["XP_645279.1","XP_640859.2",0.79],["XP_645279.1","XP_645113.1",0.671],["XP_645279.1","XP_647204.1",0.78],["XP_647204.1","NP_050086.1",0.688],["XP_647204.1","XP_637931.1",0.813],["XP_647204.1","XP_638310.1",0.757],["XP_647204.1","XP_640859.2",0.682],["XP_647204.1","XP_645113.1",0.744],["XP_637931.1","NP_050086.1",0.547],["XP_637931.1","XP_638310.1",0.744],["XP_637931.1","XP_645113.1",0.839],["XP_637931.1","XP_640859.2",0.745],["XP_638310.1","NP_050086.1",0.821],["XP_638310.1","XP_640859.2",0.532],["XP_638310.1","XP_645113.1",0.715],["XP_645113.1","NP_050086.1",0.759],["XP_640859.2","NP_050086.1",0.621]],"all_go_terms":{"GO:0006506":1,"GO:0000045":1,"GO:0034975":1,"GO:0046325":2,"GO:0038016":2,"GO:0046627":2,"GO:0042733":2,"GO:0051898":2,"GO:0099132":1,"GO:0042777":1,"GO:0015031":1,"GO:0032979":1},"recipe_readded":[]}