{"hash":"266249153102797499","title":"Secretory trafficking and Wnt signaling in development","description":"The top terms point to COPI-coated vesicles and ER\u2013Golgi transport, lysosome targeting, and secretion of Wnt proteins, with supporting hints from rhodopsin biosynthesis and axis/developmental processes. This implies a cluster of proteins involved in the secretory/trafficking machinery that supports developmental signaling and specialized protein production, rather than a single linear pathway. ","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"members":[{"accession":"XP_643365.1","go_terms":[]},{"accession":"XP_636960.1","go_terms":["GO:0032525","GO:0006888","GO:0001893","GO:0090161","GO:0006621","GO:0061357","GO:0048042","GO:0007311","GO:0048205","GO:0002121","GO:0035964","GO:0070863","GO:1902003"]},{"accession":"XP_638479.1","go_terms":[]},{"accession":"XP_642009.1","go_terms":["GO:0032525","GO:0006888","GO:0001893","GO:0090161","GO:0006621","GO:0061357","GO:0048042","GO:0007311","GO:0048205","GO:0002121","GO:0035964","GO:0070863","GO:1902003"]},{"accession":"XP_635862.1","go_terms":[]},{"accession":"XP_636647.1","go_terms":[]},{"accession":"XP_637399.1","go_terms":["GO:0007166","GO:0034197","GO:0071726","GO:0043654","GO:0010899","GO:0043123","GO:0035073","GO:0007608","GO:0035071","GO:0007604","GO:0030299","GO:0050830","GO:0043534","GO:0042992","GO:1905123","GO:2000121","GO:0060907","GO:0050731","GO:0033552","GO:0010886","GO:0070508","GO:0071447","GO:0071444","GO:0032735","GO:0030194","GO:0034375","GO:0001954","GO:0019934","GO:0070328","GO:0032497","GO:0044130","GO:0050702","GO:0044539","GO:0032760","GO:2000379","GO:0006622","GO:0006955","GO:0002755","GO:0034383","GO:0034384","GO:0035634","GO:0043691","GO:0051000","GO:0038124","GO:0016063","GO:0000122","GO:1900227","GO:0043277","GO:0060100","GO:0070543","GO:0042953","GO:0071222","GO:0071223","GO:2000505","GO:0055096","GO:0010867","GO:0010744","GO:0006702","GO:2000334","GO:0006707","GO:0050911","GO:1990000","GO:0007263","GO:0035461","GO:0033344","GO:0032755","GO:0001935","GO:0046867"]},{"accession":"XP_645592.1","go_terms":["GO:0033299","GO:0006622","GO:0034497","GO:0032258","GO:0030242","GO:0007601","GO:0007042","GO:0007040","GO:1904426","GO:0022008"]},{"accession":"XP_647825.1","go_terms":["GO:2001237","GO:0051044","GO:0034446","GO:0007613","GO:1903672","GO:0038044","GO:0034113","GO:0097062","GO:2000721","GO:0030593","GO:0030511","GO:0010634","GO:0007204","GO:0090074","GO:0030198","GO:0090245","GO:1901076","GO:0010888","GO:0046718","GO:0035160","GO:0006929","GO:2000811","GO:0035313","GO:0002430","GO:0001568","GO:0035640","GO:0045919","GO:0002042","GO:0043410","GO:0035987","GO:0002291","GO:0001570","GO:0032369","GO:0045715","GO:0007229","GO:0010983","GO:0035024","GO:1990771","GO:0007044","GO:0007414","GO:0035878","GO:0006507","GO:0048333","GO:0071397","GO:0001656","GO:0043277","GO:0072006","GO:0033690","GO:0071401","GO:1903238","GO:0070371","GO:0038027","GO:0032516","GO:0050748","GO:0050901","GO:0010668","GO:0003366","GO:0097205","GO:0010745","GO:0043588","GO:0097186","GO:2000536","GO:0048745","GO:0050919","GO:0052066","GO:0007157","GO:0045123","GO:0033343","GO:0010694","GO:0043113","GO:0070527","GO:0033631"]},{"accession":"XP_001134583.1","go_terms":["GO:0016063","GO:0006491","GO:0006486","GO:0006013","GO:0035010","GO:0006517"]},{"accession":"XP_646513.1","go_terms":["GO:0030245"]},{"accession":"XP_644200.1","go_terms":[]},{"accession":"XP_646514.1","go_terms":["GO:0030245"]},{"accession":"XP_647474.1","go_terms":["GO:0007166","GO:0034197","GO:0071726","GO:0043654","GO:0010899","GO:0043123","GO:0035073","GO:0007608","GO:0035071","GO:0007604","GO:0030299","GO:0050830","GO:0043534","GO:0042992","GO:1905123","GO:2000121","GO:0060907","GO:0050731","GO:0033552","GO:0010886","GO:0070508","GO:0071447","GO:0071444","GO:0032735","GO:0030194","GO:0034375","GO:0001954","GO:0019934","GO:0070328","GO:0032497","GO:0044130","GO:0050702","GO:0044539","GO:0032760","GO:2000379","GO:0006622","GO:0006955","GO:0002755","GO:0034383","GO:0034384","GO:0035634","GO:0043691","GO:0051000","GO:0038124","GO:0016063","GO:0000122","GO:1900227","GO:0043277","GO:0060100","GO:0070543","GO:0042953","GO:0071222","GO:0071223","GO:2000505","GO:0055096","GO:0010867","GO:0010744","GO:0006702","GO:2000334","GO:0006707","GO:0050911","GO:1990000","GO:0007263","GO:0035461","GO:0033344","GO:0032755","GO:0001935","GO:0046867"]}],"graph":[["XP_644200.1","XP_001134583.1",0.611],["XP_644200.1","XP_635862.1",0.566],["XP_644200.1","XP_636647.1",0.632],["XP_644200.1","XP_636960.1",0.669],["XP_644200.1","XP_637399.1",0.542],["XP_644200.1","XP_638479.1",0.66],["XP_644200.1","XP_642009.1",0.68],["XP_644200.1","XP_643365.1",0.633],["XP_644200.1","XP_647474.1",0.651],["XP_644200.1","XP_647825.1",0.73],["XP_644200.1","XP_646513.1",0.632],["XP_644200.1","XP_646514.1",0.625],["XP_644200.1","XP_645592.1",0.632],["XP_638479.1","XP_001134583.1",0.69],["XP_638479.1","XP_635862.1",0.635],["XP_638479.1","XP_636647.1",0.652],["XP_638479.1","XP_636960.1",0.693],["XP_638479.1","XP_637399.1",0.656],["XP_638479.1","XP_642009.1",0.745],["XP_638479.1","XP_643365.1",0.692],["XP_638479.1","XP_645592.1",0.664],["XP_638479.1","XP_646513.1",0.689],["XP_638479.1","XP_646514.1",0.683],["XP_638479.1","XP_647474.1",0.701],["XP_638479.1","XP_647825.1",0.751],["XP_645592.1","XP_001134583.1",0.664],["XP_645592.1","XP_635862.1",0.654],["XP_645592.1","XP_636647.1",0.659],["XP_645592.1","XP_636960.1",0.787],["XP_645592.1","XP_637399.1",0.669],["XP_645592.1","XP_642009.1",0.722],["XP_645592.1","XP_643365.1",0.695],["XP_645592.1","XP_646513.1",0.694],["XP_645592.1","XP_646514.1",0.677],["XP_645592.1","XP_647474.1",0.674],["XP_645592.1","XP_647825.1",0.726],["XP_637399.1","XP_001134583.1",0.686],["XP_637399.1","XP_635862.1",0.502],["XP_637399.1","XP_636647.1",0.621],["XP_637399.1","XP_636960.1",0.733],["XP_637399.1","XP_642009.1",0.78],["XP_637399.1","XP_643365.1",0.691],["XP_637399.1","XP_646513.1",0.654],["XP_637399.1","XP_646514.1",0.647],["XP_637399.1","XP_647474.1",0.629],["XP_637399.1","XP_647825.1",0.733],["XP_636647.1","XP_001134583.1",0.665],["XP_636647.1","XP_635862.1",0.649],["XP_636647.1","XP_636960.1",0.776],["XP_636647.1","XP_642009.1",0.644],["XP_636647.1","XP_643365.1",0.638],["XP_636647.1","XP_646513.1",0.677],["XP_636647.1","XP_646514.1",0.66],["XP_636647.1","XP_647474.1",0.669],["XP_636647.1","XP_647825.1",0.662],["XP_647825.1","XP_001134583.1",0.775],["XP_647825.1","XP_635862.1",0.734],["XP_647825.1","XP_636960.1",0.742],["XP_647825.1","XP_642009.1",0.799],["XP_647825.1","XP_643365.1",0.724],["XP_647825.1","XP_646513.1",0.707],["XP_647825.1","XP_646514.1",0.7],["XP_647825.1","XP_647474.1",0.724],["XP_643365.1","XP_001134583.1",0.636],["XP_643365.1","XP_635862.1",0.661],["XP_643365.1","XP_636960.1",0.662],["XP_643365.1","XP_642009.1",0.708],["XP_643365.1","XP_646513.1",0.672],["XP_643365.1","XP_646514.1",0.648],["XP_643365.1","XP_647474.1",0.681],["XP_001134583.1","XP_635862.1",0.681],["XP_001134583.1","XP_636960.1",0.73],["XP_001134583.1","XP_642009.1",0.741],["XP_001134583.1","XP_646513.1",0.657],["XP_001134583.1","XP_646514.1",0.636],["XP_001134583.1","XP_647474.1",0.699],["XP_635862.1","XP_636960.1",0.727],["XP_635862.1","XP_647474.1",0.682],["XP_635862.1","XP_646513.1",0.664],["XP_635862.1","XP_646514.1",0.652],["XP_635862.1","XP_642009.1",0.702],["XP_642009.1","XP_636960.1",0.747],["XP_642009.1","XP_646513.1",0.683],["XP_642009.1","XP_646514.1",0.65],["XP_642009.1","XP_647474.1",0.719],["XP_647474.1","XP_636960.1",0.719],["XP_647474.1","XP_646513.1",0.68],["XP_647474.1","XP_646514.1",0.662],["XP_646514.1","XP_636960.1",0.66],["XP_646514.1","XP_646513.1",0.585],["XP_636960.1","XP_646513.1",0.699]],"all_go_terms":{"GO:0006888":2,"GO:0032525":2,"GO:0048042":2,"GO:0002121":2,"GO:0061357":2,"GO:0035964":2,"GO:0048205":2,"GO:1902003":2,"GO:0007311":2,"GO:0006621":2,"GO:0070863":2,"GO:0090161":2,"GO:0001893":2,"GO:0010744":2,"GO:0033552":2,"GO:0007604":2,"GO:0071223":2,"GO:2000505":2,"GO:1905123":2,"GO:0042953":2,"GO:0035071":2,"GO:0035461":2,"GO:0010867":2,"GO:1990000":2,"GO:0071444":2,"GO:0006707":2,"GO:0001954":2,"GO:0019934":2,"GO:0071222":2,"GO:0046867":2,"GO:0002755":2,"GO:0000122":2,"GO:0006622":3,"GO:0007166":2,"GO:0030194":2,"GO:0032760":2,"GO:0033344":2,"GO:0050702":2,"GO:0034375":2,"GO:0060907":2,"GO:0044130":2,"GO:0060100":2,"GO:0070328":2,"GO:0007608":2,"GO:0034197":2,"GO:2000379":2,"GO:0006955":2,"GO:0016063":3,"GO:0006702":2,"GO:0042992":2,"GO:0035073":2,"GO:0010886":2,"GO:0043534":2,"GO:0034383":2,"GO:0030299":2,"GO:0051000":2,"GO:0043277":3,"GO:0038124":2,"GO:0032755":2,"GO:0050731":2,"GO:0010899":2,"GO:0032735":2,"GO:0034384":2,"GO:0071447":2,"GO:0007263":2,"GO:0071726":2,"GO:2000334":2,"GO:0070508":2,"GO:0070543":2,"GO:0001935":2,"GO:0043691":2,"GO:0050911":2,"GO:0044539":2,"GO:0050830":2,"GO:0055096":2,"GO:2000121":2,"GO:0043123":2,"GO:0032497":2,"GO:0035634":2,"GO:0043654":2,"GO:1900227":2,"GO:0032258":1,"GO:0007042":1,"GO:0033299":1,"GO:0022008":1,"GO:0007040":1,"GO:0030242":1,"GO:1904426":1,"GO:0034497":1,"GO:0007601":1,"GO:0010888":1,"GO:0035313":1,"GO:0007204":1,"GO:0035640":1,"GO:0010983":1,"GO:0032369":1,"GO:0035878":1,"GO:0010694":1,"GO:1903238":1,"GO:0006929":1,"GO:0071401":1,"GO:0051044":1,"GO:0002430":1,"GO:0035160":1,"GO:0002042":1,"GO:0072006":1,"GO:0033631":1,"GO:0006507":1,"GO:0043410":1,"GO:0046718":1,"GO:0048333":1,"GO:0038027":1,"GO:1901076":1,"GO:2000721":1,"GO:0007229":1,"GO:0048745":1,"GO:0030198":1,"GO:0050748":1,"GO:0033343":1,"GO:0097062":1,"GO:0090245":1,"GO:2000811":1,"GO:0035024":1,"GO:0007414":1,"GO:0050919":1,"GO:0010634":1,"GO:2000536":1,"GO:0043588":1,"GO:0052066":1,"GO:0038044":1,"GO:0001570":1,"GO:0010668":1,"GO:0090074":1,"GO:0007157":1,"GO:2001237":1,"GO:0002291":1,"GO:0097205":1,"GO:0097186":1,"GO:0034113":1,"GO:0030511":1,"GO:0071397":1,"GO:0007613":1,"GO:0034446":1,"GO:1903672":1,"GO:0001568":1,"GO:0045919":1,"GO:0035987":1,"GO:0001656":1,"GO:0033690":1,"GO:0003366":1,"GO:1990771":1,"GO:0045715":1,"GO:0070371":1,"GO:0030593":1,"GO:0032516":1,"GO:0010745":1,"GO:0070527":1,"GO:0007044":1,"GO:0043113":1,"GO:0050901":1,"GO:0045123":1,"GO:0006013":1,"GO:0006486":1,"GO:0035010":1,"GO:0006491":1,"GO:0006517":1,"GO:0030245":2},"recipe_readded":[]}