{"hash":"237935939310272241","title":"P53-mediated translation and cell cycle regulation","description":"The cluster combines translation-related terms (translation, cytoplasmic translation) with cell-cycle regulation and p53 pathway signaling (positive regulation of signal transduction by p53 class mediator), plus ubiquitin-related regulation and protein stabilization. This pattern suggests a coordinated program linking protein synthesis, stability, and cell-cycle control in a stress response, potentially involving p53-driven regulatory axes and DNA-damage responses such as to actinomycin D. Hence the label emphasizes the p53-associated control of translation and the cell cycle as the core theme.","confidence":"Medium","size":7,"edges":6,"triangles":1,"max_degree":5,"top_function":"cytoplasmic translation","members":[{"accession":"XP_640698.1","go_terms":["GO:0002181","GO:0001576"]},{"accession":"NP_050096.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"NP_050091.1","go_terms":["GO:0002181","GO:1990090","GO:0032543"]},{"accession":"XP_638746.1","go_terms":["GO:0000462","GO:0006412"]},{"accession":"XP_642043.1","go_terms":["GO:0042273","GO:0006364","GO:0016236","GO:0006412","GO:0051298","GO:0042256"]},{"accession":"XP_644192.1","go_terms":["GO:0002181","GO:1990090","GO:0032543"]},{"accession":"XP_635797.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]}],"graph":[["XP_644192.1","XP_642043.1",0.718],["NP_050096.1","XP_642043.1",0.599],["XP_642043.1","NP_050091.1",0.708],["XP_642043.1","XP_635797.1",0.742],["XP_642043.1","XP_638746.1",0.829],["NP_050091.1","XP_638746.1",0.741]],"all_go_terms":{"GO:0001576":1,"GO:0002181":3,"GO:1904667":2,"GO:0006412":4,"GO:2000059":2,"GO:0072717":2,"GO:0071158":2,"GO:1901798":2,"GO:0050821":2,"GO:0032986":2,"GO:0071157":2,"GO:0032543":2,"GO:1990090":2,"GO:0000462":1,"GO:0016236":1,"GO:0042256":1,"GO:0006364":1,"GO:0051298":1,"GO:0042273":1},"recipe_readded":[]}