{"hash":"603819765642517036","title":"Amino Acid Metabolism and Heme Biosynthesis","description":"The cluster centers on amino acid turnover (aspartate, kynurenine, lysine) and related intermediates (oxaloacetate) with biosynthesis of cofactors such as biotin and heme/porphyrin. This combination suggests a cohesive metabolic module linking amino acid catabolism with porphyrin/heme biosynthesis.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","members":[{"accession":"NP_001015914.1","go_terms":["GO:1904482","GO:0034340","GO:0035999","GO:0009113","GO:0046655","GO:0006565","GO:0006564","GO:0006231","GO:0051289","GO:0019264","GO:0017148","GO:0032259"]},{"accession":"NP_989284.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"NP_001007880.1","go_terms":["GO:1904482","GO:0034340","GO:0035999","GO:0009113","GO:0046655","GO:0006565","GO:0006564","GO:0006231","GO:0051289","GO:0019264","GO:0017148","GO:0032259"]},{"accession":"XP_031746268.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"NP_998829.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"NP_001016805.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_002934225.2","go_terms":["GO:0009116","GO:0019464","GO:0055114","GO:0006545","GO:0006567","GO:0006570","GO:0006569"]},{"accession":"XP_012823761.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_031746271.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"NP_001006790.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0006536","GO:0006103","GO:0006559","GO:0046689","GO:0006572","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103"]},{"accession":"NP_001011226.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"NP_001016936.1","go_terms":["GO:0019491","GO:0048148","GO:0017000","GO:0009450","GO:0009413","GO:0055129","GO:0009102","GO:0019878","GO:0015995","GO:0006782","GO:0006593","GO:0010121","GO:0009447","GO:0019481","GO:0019483","GO:0042450","GO:0009089"]},{"accession":"NP_001017306.1","go_terms":["GO:0007494","GO:0048566","GO:0031016","GO:0031076","GO:0009450","GO:0060324","GO:0021983","GO:0021915","GO:0042572","GO:0042574","GO:0048384","GO:0021768","GO:0035799","GO:0014032","GO:0050885","GO:0009258","GO:0001568","GO:0006540","GO:0042904","GO:0043584","GO:0019545","GO:0019544","GO:1901023","GO:0009954","GO:0019285","GO:0007584","GO:0060013","GO:0070384","GO:0060166","GO:0009447","GO:0003007","GO:0035115","GO:0051591","GO:0010133","GO:0006678","GO:0042472","GO:0009952","GO:0002072","GO:0019413","GO:0036293","GO:0055129","GO:0015976","GO:0032180","GO:0048738","GO:0071300","GO:0006537","GO:0030900","GO:0030902","GO:0009855","GO:0001936","GO:0006068","GO:0006069","GO:0044210","GO:0006526","GO:0046939","GO:0035975","GO:0009089","GO:0019877","GO:0019546","GO:0009090","GO:0009088"]},{"accession":"NP_001072543.1","go_terms":["GO:0019367","GO:0051790","GO:0017000","GO:0051792"]}],"graph":[["XP_002934225.2","XP_012823761.1",0.813],["XP_002934225.2","XP_031746268.1",0.831],["XP_002934225.2","XP_031746271.1",0.78],["XP_002934225.2","NP_001006790.1",0.813],["XP_002934225.2","NP_001007880.1",0.824],["XP_002934225.2","NP_001011226.1",0.791],["XP_002934225.2","NP_001015914.1",0.803],["XP_002934225.2","NP_001016805.1",0.766],["XP_002934225.2","NP_001016936.1",0.81],["XP_002934225.2","NP_001017306.1",0.814],["XP_002934225.2","NP_001072543.1",0.769],["XP_002934225.2","NP_989284.1",0.82],["XP_002934225.2","NP_998829.1",0.831],["NP_001072543.1","NP_001006790.1",0.772],["NP_001072543.1","NP_001007880.1",0.783],["NP_001072543.1","NP_001011226.1",0.513],["NP_001072543.1","NP_001015914.1",0.788],["NP_001072543.1","NP_001016805.1",0.631],["NP_001072543.1","NP_001016936.1",0.726],["NP_001072543.1","NP_001017306.1",0.72],["NP_001072543.1","NP_989284.1",0.765],["NP_001072543.1","NP_998829.1",0.786],["NP_001072543.1","XP_012823761.1",0.783],["NP_001072543.1","XP_031746268.1",0.769],["NP_001072543.1","XP_031746271.1",0.767],["NP_001007880.1","NP_001016936.1",0.828],["NP_001007880.1","NP_001017306.1",0.745],["NP_001007880.1","NP_001016805.1",0.853],["NP_001007880.1","NP_001015914.1",0.824],["NP_001007880.1","NP_001006790.1",0.804],["NP_001007880.1","NP_001011226.1",0.77],["NP_001007880.1","NP_989284.1",0.803],["NP_001007880.1","NP_998829.1",0.811],["NP_001007880.1","XP_012823761.1",0.826],["NP_001007880.1","XP_031746268.1",0.806],["NP_001007880.1","XP_031746271.1",0.82],["XP_012823761.1","XP_031746268.1",0.828],["XP_012823761.1","XP_031746271.1",0.82],["XP_012823761.1","NP_001006790.1",0.839],["XP_012823761.1","NP_001011226.1",0.799],["XP_012823761.1","NP_001015914.1",0.834],["XP_012823761.1","NP_001016805.1",0.835],["XP_012823761.1","NP_001016936.1",0.793],["XP_012823761.1","NP_001017306.1",0.821],["XP_012823761.1","NP_989284.1",0.826],["XP_012823761.1","NP_998829.1",0.787],["XP_031746268.1","NP_989284.1",0.814],["XP_031746268.1","NP_998829.1",0.84],["XP_031746268.1","XP_031746271.1",0.818],["XP_031746268.1","NP_001006790.1",0.838],["XP_031746268.1","NP_001011226.1",0.848],["XP_031746268.1","NP_001015914.1",0.816],["XP_031746268.1","NP_001016805.1",0.848],["XP_031746268.1","NP_001016936.1",0.798],["XP_031746268.1","NP_001017306.1",0.843],["NP_001016805.1","NP_001006790.1",0.8],["NP_001016805.1","NP_001011226.1",0.807],["NP_001016805.1","NP_001015914.1",0.828],["NP_001016805.1","NP_001016936.1",0.839],["NP_001016805.1","NP_001017306.1",0.794],["NP_001016805.1","NP_989284.1",0.817],["NP_001016805.1","NP_998829.1",0.837],["NP_001016805.1","XP_031746271.1",0.854],["NP_001011226.1","NP_001006790.1",0.819],["NP_001011226.1","NP_001015914.1",0.817],["NP_001011226.1","NP_001016936.1",0.85],["NP_001011226.1","NP_001017306.1",0.751],["NP_001011226.1","NP_989284.1",0.838],["NP_001011226.1","NP_998829.1",0.803],["NP_001011226.1","XP_031746271.1",0.823],["NP_001016936.1","NP_001006790.1",0.821],["NP_001016936.1","NP_001015914.1",0.82],["NP_001016936.1","NP_001017306.1",0.848],["NP_001016936.1","NP_989284.1",0.812],["NP_001016936.1","NP_998829.1",0.784],["NP_001016936.1","XP_031746271.1",0.799],["NP_001017306.1","NP_001006790.1",0.767],["NP_001017306.1","NP_001015914.1",0.774],["NP_001017306.1","NP_989284.1",0.74],["NP_001017306.1","NP_998829.1",0.832],["NP_001017306.1","XP_031746271.1",0.79],["XP_031746271.1","NP_989284.1",0.83],["XP_031746271.1","NP_998829.1",0.807],["XP_031746271.1","NP_001006790.1",0.828],["XP_031746271.1","NP_001015914.1",0.81],["NP_989284.1","NP_001006790.1",0.837],["NP_989284.1","NP_001015914.1",0.82],["NP_989284.1","NP_998829.1",0.826],["NP_998829.1","NP_001006790.1",0.795],["NP_998829.1","NP_001015914.1",0.804],["NP_001015914.1","NP_001006790.1",0.819]],"all_go_terms":{"GO:0006564":4,"GO:1904482":2,"GO:0051289":2,"GO:0034340":2,"GO:0046655":2,"GO:0032259":2,"GO:0035999":2,"GO:0009113":2,"GO:0006231":2,"GO:0006565":2,"GO:0019264":2,"GO:0017148":2,"GO:0051591":3,"GO:0019878":9,"GO:0006533":8,"GO:0043420":2,"GO:0019518":8,"GO:0006107":8,"GO:0019551":8,"GO:0019442":2,"GO:0034516":2,"GO:0033512":8,"GO:0042866":2,"GO:0097053":8,"GO:0008615":2,"GO:0046724":2,"GO:0006783":8,"GO:0019265":2,"GO:0042853":8,"GO:0042218":8,"GO:0033585":8,"GO:0019441":8,"GO:0006686":8,"GO:0019700":2,"GO:0007219":8,"GO:0032869":8,"GO:0006523":8,"GO:0018283":2,"GO:0015908":8,"GO:0055089":8,"GO:0009862":8,"GO:0000105":8,"GO:0051384":2,"GO:0019805":2,"GO:0019550":8,"GO:0009236":8,"GO:0046511":8,"GO:0006782":9,"GO:0070903":2,"GO:0033362":8,"GO:0034354":2,"GO:0006571":8,"GO:0006546":2,"GO:0019448":2,"GO:0009835":8,"GO:0009436":2,"GO:0044571":2,"GO:0006532":8,"GO:0009102":9,"GO:0034276":8,"GO:0006351":8,"GO:0009116":1,"GO:0019464":1,"GO:0006569":1,"GO:0006567":1,"GO:0006570":1,"GO:0006545":1,"GO:0055114":1,"GO:0046689":1,"GO:0009246":1,"GO:0006559":1,"GO:0046677":1,"GO:0009243":1,"GO:0017000":3,"GO:0071555":1,"GO:0006536":1,"GO:0009245":1,"GO:0006103":1,"GO:0009103":1,"GO:0006572":1,"GO:0010121":1,"GO:0048148":1,"GO:0015995":1,"GO:0019481":1,"GO:0055129":2,"GO:0006593":1,"GO:0042450":1,"GO:0019491":1,"GO:0009450":2,"GO:0009447":2,"GO:0009089":2,"GO:0009413":1,"GO:0019483":1,"GO:0019413":1,"GO:0007494":1,"GO:0003007":1,"GO:0071300":1,"GO:0046939":1,"GO:0002072":1,"GO:0001568":1,"GO:0048738":1,"GO:0035115":1,"GO:0006069":1,"GO:0009855":1,"GO:0015976":1,"GO:0007584":1,"GO:0043584":1,"GO:0006537":1,"GO:0031016":1,"GO:0010133":1,"GO:0009258":1,"GO:0021983":1,"GO:0001936":1,"GO:0006526":1,"GO:0048384":1,"GO:0048566":1,"GO:0042574":1,"GO:0021768":1,"GO:0009088":1,"GO:0019544":1,"GO:0036293":1,"GO:0019285":1,"GO:0032180":1,"GO:0006068":1,"GO:0006540":1,"GO:0009952":1,"GO:0042904":1,"GO:0060166":1,"GO:0021915":1,"GO:1901023":1,"GO:0006678":1,"GO:0060324":1,"GO:0044210":1,"GO:0019545":1,"GO:0035799":1,"GO:0070384":1,"GO:0030900":1,"GO:0014032":1,"GO:0042472":1,"GO:0019877":1,"GO:0050885":1,"GO:0031076":1,"GO:0060013":1,"GO:0009954":1,"GO:0035975":1,"GO:0030902":1,"GO:0009090":1,"GO:0042572":1,"GO:0019546":1,"GO:0051792":1,"GO:0051790":1,"GO:0019367":1},"recipe_readded":[]}