{"hash":"603476007537124542","title":"Neddylation and Ubiquitination Regulation","description":"This cluster\u2019s top GO terms center on the regulation and execution of protein neddylation (and related ubiquitin-protein transferase activity), along with protein catabolic processes. The presence of both positive and negative regulation of neddylation suggests a core functional theme around NEDD8-mediated modification and its control, which often interfaces with ubiquitin-proteasome\u2013driven proteolysis and cellular stress responses (including radiation-related signals) and may extend to cytoskeletal dynamics. Overall, the common thread appears to be post-translational modification by neddylation and its regulation within proteostasis and stress contexts.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"NP_001096288.1","go_terms":["GO:2000436","GO:0045116","GO:0051443","GO:0010332","GO:2000435","GO:0010225","GO:0044254"]},{"accession":"NP_001096466.1","go_terms":["GO:0001578","GO:0046785"]},{"accession":"NP_001007916.1","go_terms":[]}],"graph":[],"all_go_terms":{"GO:2000436":1,"GO:0010332":1,"GO:2000435":1,"GO:0044254":1,"GO:0051443":1,"GO:0045116":1,"GO:0010225":1,"GO:0001578":1,"GO:0046785":1},"recipe_readded":["XP_002937618.3","XP_031752528.1","XP_004918696.1","XP_031761554.1","XP_002937338.2","XP_004911684.1","NP_001096260.1","NP_001190195.1","XP_002942649.3","XP_031754322.1","XP_031753424.1","XP_002934710.2","NP_001119543.1","NP_001123829.1","XP_004913100.1","XP_002939670.3","NP_001006791.2","XP_012820272.1","XP_002937892.1","XP_002941428.1"]}