{"hash":"340534425669385147","title":"ER Targeting and Translocation","description":"This cluster centers on proteins destined for the endoplasmic reticulum and their movement via SRP-dependent cotranslational targeting, post-translational targeting, and Sec-mediated transport, plus ER-to-cytosol retrograde transport. The dominant GO terms (GO:0006616, GO:0031204, GO:0043952, GO:0030970) point to ER targeting and translocation machinery, with a few ancillary translation initiation and telomere localization terms likely incidental. Overall, the theme is cohesive around ER targeting and membrane translocation.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"members":[{"accession":"NP_001005080.1","go_terms":["GO:0006614"]},{"accession":"XP_012824635.1","go_terms":["GO:0031118","GO:0031119","GO:0032212","GO:0031120","GO:1904851","GO:1904874","GO:1990481","GO:0090669","GO:0051973","GO:0000495","GO:0007004","GO:0040008","GO:0032790","GO:0001731","GO:0002188","GO:0006400","GO:0055129","GO:0002192","GO:0007049"]},{"accession":"NP_001004801.1","go_terms":["GO:0070843","GO:0006605","GO:0039019","GO:0030970","GO:0043952","GO:0031204","GO:0006616","GO:0007275","GO:0006620","GO:0030433"]},{"accession":"NP_001016718.1","go_terms":["GO:2000032","GO:0090506","GO:0031581","GO:0000028","GO:0034198","GO:0006407"]},{"accession":"NP_001106402.1","go_terms":["GO:0032979","GO:0015031"]},{"accession":"XP_004915421.1","go_terms":["GO:0009306","GO:0006605","GO:0031204","GO:0043952","GO:0006616"]},{"accession":"NP_001005129.1","go_terms":["GO:0019044","GO:0006281","GO:0006627","GO:0006465","GO:0045892","GO:0009432","GO:0006260","GO:0006351","GO:0000746"]},{"accession":"NP_001103514.1","go_terms":["GO:0043547","GO:0000060","GO:0030970","GO:0006616","GO:0030433","GO:0031204"]},{"accession":"XP_012813704.1","go_terms":["GO:0032147","GO:0042254"]}],"graph":[["NP_001103514.1","NP_001004801.1",0.558],["NP_001103514.1","NP_001005080.1",0.655],["NP_001103514.1","NP_001005129.1",0.783],["NP_001103514.1","NP_001016718.1",0.868],["NP_001103514.1","NP_001106402.1",0.67],["NP_001103514.1","XP_004915421.1",0.773],["NP_001103514.1","XP_012813704.1",0.712],["NP_001103514.1","XP_012824635.1",0.844],["XP_004915421.1","XP_012824635.1",0.75],["XP_004915421.1","XP_012813704.1",0.787],["XP_004915421.1","NP_001004801.1",0.618],["XP_004915421.1","NP_001005080.1",0.7],["XP_004915421.1","NP_001005129.1",0.765],["XP_004915421.1","NP_001016718.1",0.772],["XP_004915421.1","NP_001106402.1",0.631],["NP_001005129.1","NP_001004801.1",0.571],["NP_001005129.1","NP_001005080.1",0.725],["NP_001005129.1","NP_001016718.1",0.689],["NP_001005129.1","NP_001106402.1",0.621],["NP_001005129.1","XP_012813704.1",0.665],["NP_001005129.1","XP_012824635.1",0.576],["NP_001016718.1","NP_001004801.1",0.624],["NP_001016718.1","NP_001005080.1",0.725],["NP_001016718.1","NP_001106402.1",0.747],["NP_001016718.1","XP_012813704.1",0.88],["NP_001016718.1","XP_012824635.1",0.81],["XP_012813704.1","XP_012824635.1",0.823],["XP_012813704.1","NP_001004801.1",0.529],["XP_012813704.1","NP_001005080.1",0.703],["XP_012813704.1","NP_001106402.1",0.674],["NP_001005080.1","NP_001004801.1",0.596],["NP_001005080.1","NP_001106402.1",0.556],["NP_001005080.1","XP_012824635.1",0.805],["XP_012824635.1","NP_001004801.1",0.74],["XP_012824635.1","NP_001106402.1",0.702],["NP_001106402.1","NP_001004801.1",0.641]],"all_go_terms":{"GO:0006614":1,"GO:0001731":1,"GO:1904874":1,"GO:1904851":1,"GO:0031119":1,"GO:0007049":1,"GO:0007004":1,"GO:0055129":1,"GO:1990481":1,"GO:0090669":1,"GO:0032790":1,"GO:0051973":1,"GO:0040008":1,"GO:0002188":1,"GO:0031120":1,"GO:0006400":1,"GO:0000495":1,"GO:0002192":1,"GO:0031118":1,"GO:0032212":1,"GO:0030433":2,"GO:0070843":1,"GO:0031204":3,"GO:0006616":3,"GO:0030970":2,"GO:0039019":1,"GO:0006605":2,"GO:0006620":1,"GO:0007275":1,"GO:0043952":2,"GO:2000032":1,"GO:0006407":1,"GO:0031581":1,"GO:0090506":1,"GO:0034198":1,"GO:0000028":1,"GO:0032979":1,"GO:0015031":1,"GO:0009306":1,"GO:0006465":1,"GO:0006627":1,"GO:0009432":1,"GO:0045892":1,"GO:0000746":1,"GO:0019044":1,"GO:0006281":1,"GO:0006351":1,"GO:0006260":1,"GO:0000060":1,"GO:0043547":1,"GO:0032147":1,"GO:0042254":1},"recipe_readded":[]}