[{"hash":"1261234177148952964","title":"Immunoglobulin production and plasma cell differentiation","description":"The cluster shows strong enrichment for immune-secretory functions, notably immunoglobulin production (GO:0002377) and plasma cell differentiation (GO:0002317), with the endoplasmic reticulum unfolded protein response (GO:0030968) supporting antibody production in plasma cells. While there are angiogenesis/endothelial-related terms present, the dominant signal is antibody-secreting cell activity, making this a representative label for the cluster. ","confidence":"Medium","size":29,"edges":44,"triangles":20,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0097421","count":2},{"id":"GO:0030968","count":2},{"id":"GO:0002377","count":2},{"id":"GO:0042985","count":2}]},{"hash":"60893127520974874","title":"Ribosome biogenesis and translation","description":"Based on the top GO terms, the cluster is strongly enriched for processes involving ribosome assembly/biogenesis (especially small subunit) and multiple stages of cytoplasmic translation (initiation, elongation are not listed but initiation and termination, plus translation overall, are present), including maturation of rRNA. This points to a cohesive group of ribosome-related proteins functioning in assembling and carrying out protein synthesis, with a minor note of antibiotic response possibly reflecting translation stress.","confidence":"High","size":29,"edges":399,"triangles":3476,"max_degree":28,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":23},{"id":"GO:0042254","count":12},{"id":"GO:0000462","count":7},{"id":"GO:0006413","count":7},{"id":"GO:0046677","count":6}]},{"hash":"375590413329950908","title":"Adaptive immune activation and immune synapse regulation","description":"The top GO terms point to adaptive immune responses and regulation of various immune cell activities (T cells, NK cells, macrophages), alongside processes for immune synapse formation and actin cytoskeleton remodeling during cell-cell adhesion. Together, these suggest a cluster of proteins coordinating immune signaling, activation, and cytoskeletal dynamics at immune synapses. Some peripheral terms reflect broader cellular remodeling but do not override the central theme.","confidence":"High","size":29,"edges":31,"triangles":9,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":5},{"id":"GO:0043031","count":5},{"id":"GO:0043318","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0051963","count":5}]},{"hash":"243708321226364306","title":"DNA Replication and Repair Machinery","description":"The cluster is dominated by DNA replication, primer synthesis, nucleotide-excision repair, and recombination terms, with SOS response signals, indicating a genome maintenance program. A splicing term appears as an outlier, but overall the proteins group around replication/repair functions.","confidence":"High","size":29,"edges":389,"triangles":3226,"max_degree":28,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":13},{"id":"GO:0009432","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0006269","count":7},{"id":"GO:0006289","count":7}]},{"hash":"366726389387425075","title":"Drosophila oogenesis transcriptional regulation","description":"This cluster centers on regulation of DNA-templated transcription and RNA polymerase II\u2013mediated control, suggesting transcriptional programs governing cell fate during oogenesis. It also includes GO terms tied to ovarian development, such as follicle cell stalk formation and germarium-derived cyst encapsulation, pointing to coordinated transcriptional regulation during germline and follicle differentiation. The presence of spindle assembly terms hints at cell division processes active during oogenesis. Some terms appear more general (e.g., urogenital development, granulocyte differentiation), but the core pattern supports a theme of transcriptional control in germline/ovarian development.","confidence":"Medium","size":29,"edges":369,"triangles":2904,"max_degree":28,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":7},{"id":"GO:0051225","count":6},{"id":"GO:0061188","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0000122","count":5}]},{"hash":"1245627357552154630","title":"Ubiquitin-Mediated Regulation of Transcription and Cytoskeleton","description":"The top GO terms cluster around ubiquitin-related regulation (K63-linked deubiquitination; ubiquitin-dependent catabolic processes; histone H2A monoubiquitination; histone deacetylase activity modulation) together with transcriptional control (negative regulation of RNA Pol II) and RNA processing (alternative splicing via spliceosome). Additionally, cytoskeletal and endocytic processes (Rho signaling, microspike assembly, pinocytosis) are represented. This suggests a cohesive theme where ubiquitin signaling modulates transcription/RNA processing and cytoskeletal dynamics, justifying this label.","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0035518","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0008542","count":4},{"id":"GO:0000381","count":4}]},{"hash":"1478958903399057236","title":"Neuronal cell adhesion and paranodal junction assembly","description":"The GO terms cluster around neural cell adhesion and axonal junction organization, including heterophilic/homophilic cell adhesion, paranodal junction assembly, juxtaparanode region adhesion, and regulation of synapse assembly, as well as specialized neuronal adhesion in AV node/His bundle contexts. These together point to a cohesive theme of neural cell\u2013cell adhesion and paranodal/synaptic junction formation, with some immune-regulatory terms likely reflecting broader roles of adhesion molecules. ","confidence":"High","size":29,"edges":327,"triangles":2257,"max_degree":27,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0007156","count":8},{"id":"GO:0046718","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0086072","count":8}]},{"hash":"2104777714138745700","title":"Immune activation and leukocyte trafficking","description":"The cluster\u2019s top GO terms are strongly skewed toward immune functions: phagocytosis recognition, Fc-gamma receptor signaling, basophil activation, and leukocyte tethering/rolling, indicating proteins linked to immune cell activation and recruitment. Some terms related to development (cartilage condensation, lymph vessel morphogenesis, metanephric development) appear among the top terms, suggesting possible secondary roles or shared pathway components, but the immune-related processes are the most representative theme. ","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":28},{"id":"GO:0001502","count":28},{"id":"GO:0072287","count":26},{"id":"GO:0038094","count":26},{"id":"GO:0071226","count":26}]},{"hash":"51984907758768128","title":"Neuronal development and synapse formation","description":"This cluster is dominated by terms tied to neural connectivity and circuit assembly: synapse formation, corpus callosum development, axonal fasciculation, and regulation of Rho signaling\u2014all key for axon guidance and neural network wiring. The presence of sensory (sound) perception and vocalization hints at the functional outputs of these neural circuits, while cellular responses to mechanical stimuli and apoptotic processes relate to remodeling during development. Altogether, the terms converge on neuronal development, axon guidance, and synapse formation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0022038","count":3},{"id":"GO:0048681","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0007413","count":3}]},{"hash":"409567999371499671","title":"Cerebellar synapse formation and neural development","description":"This cluster is dominated by terms related to synapse assembly and function (chemical synaptic transmission, synaptic vesicle targeting), cerebellar development (Purkinje cell layer formation), and neural signaling, with supporting terms on neuronal adhesion and trafficking (zonula adherens, Golgi localization, protein localization). Together these indicate a cohesive theme of cerebellar neuron synapse formation and related neural development processes.","confidence":"High","size":29,"edges":393,"triangles":3332,"max_degree":28,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0045186","count":29},{"id":"GO:0051683","count":29},{"id":"GO:2000009","count":29},{"id":"GO:0007605","count":29},{"id":"GO:0035750","count":29}]},{"hash":"1653701339848073199","title":"T cell activation and NF-kB signaling","description":"The cluster is dominated by immune-related terms, including positive regulation of canonical NF-kappaB signaling, T cell costimulation, T cell activation via T cell receptor\u2013MHC interaction, cytokine production, and macrophage chemotaxis, pointing to adaptive immune signaling and intercellular communication. Some terms (retina layer formation, DNA metabolic process) appear less central, but the overall theme is clearly immune response. ","confidence":"High","size":29,"edges":102,"triangles":122,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043123","count":18},{"id":"GO:0010842","count":12},{"id":"GO:1900242","count":12},{"id":"GO:0007165","count":11},{"id":"GO:0031295","count":11}]},{"hash":"1520783278127069053","title":"Endothelial adhesion and vascular development","description":"This cluster centers on endothelial biology and vascular formation, with strong representation of endothelial adhesion (cell-matrix and integrin-mediated), activation, and differentiation, plus endothelial chemotaxis. The inclusion of ventricular septum development and BMP signaling regulation suggests cardiac/heart vascular development involvement, and blood coagulation aligns with endothelial functions in hemostasis, making a cohesive endothelial-vascular developmental theme. ","confidence":"High","size":29,"edges":53,"triangles":35,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":10},{"id":"GO:0007160","count":9},{"id":"GO:0030514","count":9},{"id":"GO:0035767","count":8},{"id":"GO:0001558","count":8}]},{"hash":"2021451010210564528","title":"Neural development and synapse formation","description":"The cluster is enriched for nervous system development, corpus callosum development, and synapse assembly terms, with supporting collagen organization and angiogenesis terms that often accompany brain development and vascularization, suggesting roles in neural development and connectivity rather than unrelated processes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":8},{"id":"GO:0045087","count":7},{"id":"GO:0014068","count":7},{"id":"GO:0051092","count":6},{"id":"GO:0007275","count":6}]},{"hash":"1705366601871723834","title":"Cardiac contraction and heart morphogenesis","description":"The strongest signals in this cluster are cardiac-focused: cardiac muscle contraction, ventricular heart morphogenesis, and muscle fiber-type switching, plus regulation of muscle filament sliding. This points to a cohesive set of proteins involved in heart muscle function and development. The presence of axonogenesis and substantia nigra development terms suggests some neural-related roles or shared pathways, but the dominant theme remains cardiac muscle biology. Therefore, a label centered on cardiac contraction and heart morphogenesis best captures the cluster\u2019s core function.","confidence":"Medium","size":29,"edges":48,"triangles":19,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060048","count":23},{"id":"GO:0055010","count":21},{"id":"GO:0014883","count":21},{"id":"GO:0032972","count":21},{"id":"GO:0007409","count":16}]},{"hash":"2304223318398613487","title":"Embryonic Development and Morphogenesis","description":"Most of the top GO terms describe developmental and morphogenetic processes across tissues: roof of mouth development, left/right pattern formation, hair follicle morphogenesis, endocrine system development, and epithelial-to-mesenchymal transition involved in endocardial cushion formation. Together they suggest a cluster of proteins involved in regulating development and tissue organization during embryogenesis. A few terms relate to general cellular processes (splicing, transcription regulation), but the dominant signal is developmental/morphogenetic activity.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":4},{"id":"GO:0000055","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0031069","count":4}]},{"hash":"1584273353486471315","title":"Neuroimmune signaling and autophagy","description":"The terms combine neural processes (dopamine secretion regulation, long-term synaptic potentiation, brain development) with immune functions (B cell differentiation, B cell receptor signaling) and cellular maintenance (ribophagy, apoptosis regulation, aging, extravasation). This suggests a theme of neuroimmune communication coupled with autophagy/turnover, capturing both nervous and immune signaling alongside cellular quality control. ","confidence":"Medium","size":29,"edges":24,"triangles":3,"max_degree":12,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0014059","count":25},{"id":"GO:0060291","count":25},{"id":"GO:0071236","count":23},{"id":"GO:0001302","count":23},{"id":"GO:0043065","count":23}]},{"hash":"1762460459311381585","title":"RNA Splicing and mRNA Processing","description":"Most terms cluster around RNA splicing and mRNA processing (regulation and positive regulation of splicing via the spliceosome, general RNA splicing, and mRNA stabilization). Circadian rhythm and apoptotic pathway terms appear as secondary themes, with androgen receptor signaling as an additional context. Thus, the core function represented is RNA splicing and mRNA processing.","confidence":"High","size":29,"edges":176,"triangles":517,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":7},{"id":"GO:0048255","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0008380","count":6},{"id":"GO:0007623","count":4}]},{"hash":"1322738801324313074","title":"Wound healing and ECM remodeling","description":"Dominated by GO terms for wound healing, epidermal/keratinocyte migration, proteolysis, collagen fibril organization, and extracellular matrix disassembly, with leukocyte migration and amelogenesis also present. This points to skin repair and matrix remodeling as the core theme.","confidence":"High","size":29,"edges":207,"triangles":630,"max_degree":27,"top_function":"wound healing","top_go_terms":[{"id":"GO:0035313","count":25},{"id":"GO:0051549","count":25},{"id":"GO:0006508","count":25},{"id":"GO:0030199","count":24},{"id":"GO:0042060","count":23}]},{"hash":"2113913274021148672","title":"Developmental organogenesis and signaling","description":"The top GO terms cluster around organ development and morphogenesis across multiple tissues (nervous system, lung, cartilage, thyroid) and engage key signaling pathways (Wnt, ERK/MAPK) and growth processes (angiogenesis, cardiac proliferation). While there is a minor immune-related term (lipopolysaccharide response), the dominant pattern points to coordinated developmental regulation and signaling, justifying a developmental organogenesis label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060045","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0090263","count":4}]},{"hash":"1650407343125574869","title":"Unknown","description":"The cluster shows a diverse set of GO terms ranging from infection structure formation to Notch signaling regulation, multiple developmental processes (intestinal, hypochord, embryonic patterning), B cell differentiation, and even meiotic division. This spread suggests no single coherent functional theme dominates the cluster, making a specific, intuitive label unlikely. ","confidence":"","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0075015","count":9},{"id":"GO:0045747","count":8},{"id":"GO:0007386","count":8},{"id":"GO:0002315","count":8},{"id":"GO:1902367","count":8}]},{"hash":"1134751953867825824","title":"Neurodevelopmental transcription and cell-cycle regulation","description":"This cluster centers on transcriptional regulation (DNA-templated transcription, negative regulation of Pol II transcription) and neural development processes (motor neuron axon guidance, neural tube closure), with accompanying cell-cycle terms (G1/S transition, meiotic cell cycle) and adhesion signals (cell-matrix adhesion). The combination suggests a cohesive theme of gene expression control within neurodevelopmental contexts, justifying the label. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000082","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0043433","count":3},{"id":"GO:0007160","count":3}]},{"hash":"1152095541641228992","title":"Cadherin-mediated cell adhesion in development","description":"The cluster centers on cell-cell adhesion terms, especially cadherin-mediated adhesion, with additional signals for neural and heart development (neuron adhesion, synapse assembly, endocardial cushion formation). This points to a theme of cadherin-family adhesion proteins coordinating tissue morphogenesis across neural and cardiac contexts.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0072006","count":8},{"id":"GO:0007605","count":7},{"id":"GO:0003273","count":7},{"id":"GO:0007399","count":7}]},{"hash":"1759109656494361141","title":"Neuronal adhesion and synapse development","description":"This cluster is strongly enriched for neural development and synaptic connectivity terms, including positive regulation of synapse assembly, neuron cell-cell and homophilic/heterophilic cell-cell adhesion, nervous system development, and glutamatergic synaptic transmission, which together point to roles in neuronal adhesion and synapse formation/communication. A few non-neural terms (ossification, nephron development) are present but don\u2019t dominate the signal, so the core theme remains neural connectivity.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":18},{"id":"GO:0007156","count":18},{"id":"GO:0007399","count":18},{"id":"GO:0007158","count":17},{"id":"GO:0007157","count":17}]},{"hash":"938340887543671787","title":"P450-driven steroid biosynthesis","description":"The cluster is dominated by GO terms related to steroid biosynthesis and metabolism (ecdysone, aldosterone, bile acids) and the omega-hydroxylase P450 pathway, plus related oxidative reactions. This points to a common function of P450-catalyzed steroid hormone production and modification, making the main theme steroid biosynthesis via cytochrome P450 enzymes. ","confidence":"High","size":29,"edges":241,"triangles":917,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0006697","count":28},{"id":"GO:0097267","count":28},{"id":"GO:0032342","count":28},{"id":"GO:0071615","count":28},{"id":"GO:0006699","count":28}]},{"hash":"446830388932520331","title":"Neural signaling and sensory processing","description":"These proteins show enrichment for nervous system functions: vision-related light detection, pain perception regulation, memory, locomotion, GPCR signaling, and glutamatergic synaptic transmission, which together point to neural signaling and sensory processing. Some terms like electron transport chain and defense response to bacterium are less specific to neurons but can be involved in general cellular metabolism and immune interactions in neural tissues. Overall, the cluster centers on neural signaling and sensory activity.","confidence":"High","size":29,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":4},{"id":"GO:0050908","count":4},{"id":"GO:0086091","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0071257","count":3}]},{"hash":"2156377358317251002","title":"SNARE-Mediated Golgi-ER Vesicle Transport","description":"This cluster is enriched for ER-to-Golgi and intra-Golgi vesicle trafficking, endosome-to-Golgi retrograde transport, and SNARE complex assembly, signaling a core SNARE-driven Golgi-ER transport theme. The presence of nervous system development and dendrite morphogenesis terms suggests this trafficking is particularly relevant in neuronal contexts, supporting a cohesive role in vesicle fusion and trafficking within neurons.","confidence":"High","size":28,"edges":206,"triangles":693,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":9},{"id":"GO:0042147","count":7},{"id":"GO:0050775","count":7},{"id":"GO:1903595","count":7},{"id":"GO:0006891","count":7}]},{"hash":"1387802044394597078","title":"Golgi and Vesicle Trafficking with GPCR Signaling","description":"The cluster is dominated by GO terms for Golgi organization and vesicle transport (endosome to melanosome), along with GPCR signaling and autophagy regulation, suggesting a core theme of intracellular trafficking linked to membrane signaling. Some terms like wound healing and neuroblast proliferation hint at broader developmental roles, but the strongest signal centers on Golgi/vesicle trafficking and associated signaling pathways.","confidence":"Medium","size":28,"edges":376,"triangles":3224,"max_degree":27,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007030","count":27},{"id":"GO:1902692","count":26},{"id":"GO:0044319","count":26},{"id":"GO:0034379","count":26},{"id":"GO:0033028","count":26}]},{"hash":"1985938935092352714","title":"RNA Modification and Processing","description":"The top GO terms are dominated by tRNA wobble uridine modification, tRNA methylation, and 7-methylguanosine mRNA capping, indicating RNA maturation/processing as the core shared function of this cluster. While there are additional terms (DNA repair, gliogenesis, nervous system development), the RNA-processing signals are the strongest common theme.","confidence":"Medium","size":28,"edges":8,"triangles":0,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0002098","count":4},{"id":"GO:0006281","count":4},{"id":"GO:0016049","count":3},{"id":"GO:0016311","count":3},{"id":"GO:0007399","count":2}]},{"hash":"654279727567152055","title":"Spliceosome-Mediated RNA Processing","description":"The prominent GO terms describe regulation and execution of splicing via the spliceosome, as well as related post-transcriptional steps like mRNA export and translation initiation, indicating a cluster focused on RNA processing and splicing regulation.","confidence":"High","size":28,"edges":152,"triangles":439,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":21},{"id":"GO:0000381","count":17},{"id":"GO:0031047","count":17},{"id":"GO:0006378","count":17},{"id":"GO:0000380","count":17}]},{"hash":"1413902015491540052","title":"Cell Cycle Control and Protein Turnover","description":"This cluster is characterized by enrichment in proteasome assembly, ubiquitination, mitotic cell cycle, and microtubule dynamics, pointing to coordinated protein turnover and regulation during cell division. Other terms like protein methylation and mRNA processing suggest broader regulatory layers in proliferating cells, but the core theme is proteostasis intertwined with mitosis.","confidence":"High","size":28,"edges":38,"triangles":15,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070682","count":5},{"id":"GO:0070389","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0006479","count":4},{"id":"GO:0016567","count":4}]},{"hash":"809727138410313858","title":"Embryonic Skeletal and Craniofacial Mesenchyme Development","description":"This cluster is enriched for embryonic development of skeletal and craniofacial structures (chondrocyte differentiation, skeletal system and palate development, and mesenchymal proliferation). The presence of stress fiber assembly and PKC activity regulation points to cytoskeletal remodeling and signaling in mesenchymal cells during organogenesis, supporting a cohesive theme of skeletal/craniofacial formation. Some terms (adrenal, gonad development) may reflect broader mesenchymal lineage programs but do not override the dominant skeletal/craniofacial signal.","confidence":"High","size":28,"edges":275,"triangles":1558,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":10},{"id":"GO:0051496","count":10},{"id":"GO:0002062","count":10},{"id":"GO:0060045","count":9},{"id":"GO:0002053","count":9}]},{"hash":"763254888271404334","title":"Embryonic organogenesis and tissue development","description":"The top GO terms converge on developmental processes and organ formation: ossification, heart development, angiogenesis, kidney development, and neural crest cell migration, plus multicellular organism development and cell-cell adhesion. The cluster likely represents proteins involved in coordinating tissue morphogenesis and organ patterning during embryogenesis. While an immune-related term appears, the dominant signal is developmental programs guiding organogenesis and tissue organization.","confidence":"High","size":28,"edges":9,"triangles":0,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":15},{"id":"GO:0007275","count":14},{"id":"GO:0007157","count":14},{"id":"GO:0032516","count":12},{"id":"GO:0007507","count":12}]},{"hash":"1254200642626651179","title":"Sarcomere Organization and Proteolysis","description":"The top GO terms indicate muscle-related structure (sarcomere organization) and proteolytic processes (self proteolysis, protein autoprocessing), with additional signals of cytoskeleton regulation. While other terms are present (immune response, development, stress responses), the strongest common theme centers on muscle structural organization tied to regulated proteolysis, suggesting a cluster of proteins involved in sarcomere maintenance and proteolytic control in response to cellular cues.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0097264","count":2},{"id":"GO:0042004","count":2},{"id":"GO:0016540","count":2}]},{"hash":"247171296129761637","title":"RNA processing and translation machinery","description":"The top GO terms cluster around translation, mRNA capping, tRNA methylation, and protein methylation, indicating a core theme of RNA maturation and protein synthesis; additional terms for heart/visual functions may reflect tissue-specific roles or less central associations, but the primary signal is RNA processing and translation.","confidence":"Medium","size":28,"edges":138,"triangles":325,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006479","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0043547","count":2}]},{"hash":"853875448691581185","title":"Circadian Regulation & Ubiquitin-Dependent Proteolysis","description":"The cluster is dominated by GO terms for circadian rhythm regulation and ubiquitin-dependent protein catabolic processes, with additional signals of development and signaling, suggesting a theme of time-regulated protein turnover that intersects with growth and neural pathways.","confidence":"Medium","size":28,"edges":80,"triangles":105,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042752","count":22},{"id":"GO:0042787","count":22},{"id":"GO:0045214","count":19},{"id":"GO:0007399","count":19},{"id":"GO:0019046","count":19}]},{"hash":"1114566359118394362","title":"Cytoskeletal Motility and Adhesion","description":"The topGO terms point to cytoskeletal remodeling and adhesion processes (lamellipodium assembly; positive regulation of cell spreading), suggesting a motility/adhesion\u2013related theme for the cluster. Other terms (splicing, transcription regulation, IP3 signaling, B cell differentiation) appear more peripheral or broad, likely representing annotation noise rather than a unifying function. Therefore, the label captures the strongest coherent signal without overstating the cluster\u2019s scope.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":4},{"id":"GO:0050859","count":3},{"id":"GO:0032298","count":3},{"id":"GO:0000055","count":3},{"id":"GO:1903026","count":3}]},{"hash":"2297451932093706347","title":"Retinal glutamatergic GPCR signaling and vision","description":"This cluster is dominated by GO terms pointing to GPCR signaling and calcium regulation (including phospholipase C-activating GPCR pathways and calcium import), plus a strong emphasis on glutamatergic synaptic transmission and light perception. The presence of \u201cdetection of light stimulus involved in visual perception\u201d and \u201cregulation of synaptic transmission, glutamatergic\u201d suggests a retina-neuron signaling context, where GPCR pathways modulate glutamatergic transmission in response to light. Although some terms like the electron transport chain are more general, they do not override the cohesive theme of retinal GPCR-driven signaling and vision. Overall, the label captures the core shared function of the cluster. ","confidence":"Medium","size":28,"edges":358,"triangles":2809,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":28},{"id":"GO:0000186","count":28},{"id":"GO:0030818","count":27},{"id":"GO:0090280","count":27},{"id":"GO:0007206","count":27}]},{"hash":"116816646535102139","title":"Developmental signaling and cell cycle","description":"The top GO terms are dominated by mitotic cell cycle and cell division, suggesting a core proliferative function. Additional terms point to nervous system development and corpus callosum development, plus various signaling-related processes (dopamine response, T cell receptor signaling), indicating a broader developmental signaling context rather than a single, narrow pathway. Thus, a label that reflects both developmental signaling and cell cycle activity seems most representative.","confidence":"Medium","size":28,"edges":10,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0007399","count":6},{"id":"GO:0051291","count":6},{"id":"GO:0031384","count":6}]},{"hash":"181490158485672422","title":"Epigenetic Chromatin Modification and Transcription Regulation","description":"The top GO terms point to histone modifications (H3 acetylation, H3-K4 and H3-K79 methylation), DNA methylation-dependent heterochromatin formation, and DNA-templated transcription, indicating epigenetic control of gene expression. Some neural development and behavior terms may reflect downstream effects of chromatin regulation in development and neural function. Overall, the cluster appears to group proteins involved in chromatin state regulation and transcriptional control.","confidence":"High","size":28,"edges":18,"triangles":2,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006349","count":5},{"id":"GO:0001843","count":5},{"id":"GO:0001662","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0043966","count":4}]},{"hash":"736963854499836675","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":11,"triangles":0,"max_degree":2,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0000398","count":8},{"id":"GO:0075713","count":6},{"id":"GO:0015074","count":6},{"id":"GO:0019068","count":6},{"id":"GO:0030260","count":6}]},{"hash":"1062564682251712663","title":"Ion transport and pH regulation","description":"The top GO terms point to transmembrane movement of ions and small molecules (chloride, bicarbonate, fructose, aspartate) and pH-related processes (intracellular pH elevation, gastric acid secretion), as well as functions tied to membrane transport. While a couple of terms (sporulation, sensory perception of sound) are less directly linked, the dominant signal across the cluster is transporter activity and acid-base homeostasis, justifying a cohesive label focused on transport and pH regulation.","confidence":"Medium","size":28,"edges":129,"triangles":480,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051454","count":16},{"id":"GO:0001696","count":16},{"id":"GO:0048240","count":16},{"id":"GO:1902476","count":16},{"id":"GO:0015701","count":14}]},{"hash":"1031335668114156306","title":"Pollen development and anther dehiscence","description":"The GO terms show strong signals for pollen exine formation and anther dehiscence, hallmark processes of male gametophyte development in plants. Additional terms like N-linked glycosylation and nucleotide catabolic processes suggest involvement in protein maturation and metabolism supporting pollen wall formation and energy turnover. Together, these terms point to a cohesive theme of reproductive development in pollen.","confidence":"High","size":28,"edges":160,"triangles":506,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006487","count":7},{"id":"GO:0010584","count":7},{"id":"GO:0046712","count":7},{"id":"GO:0009901","count":7},{"id":"GO:0046706","count":7}]},{"hash":"2184559069577571656","title":"Unknown","description":"The top GO terms span immune defense, bacterial cell wall metabolism, energy production, signaling, and even neural/behavioral processes, with no single cohesive function linking them. This diversity suggests the cluster contains heterogeneous proteins or annotation noise, making a specific, interpretable label unreliable.","confidence":"","size":28,"edges":134,"triangles":199,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":28},{"id":"GO:0019835","count":28},{"id":"GO:0019076","count":28},{"id":"GO:0009253","count":28},{"id":"GO:0007194","count":28}]},{"hash":"227394698862263318","title":"Transmembrane Transporters and Vesicle Loading","description":"The GO terms are dominated by various transmembrane transport processes (ions, sugars, vitamins, xenobiotics, and other substrates) and include a role in neurotransmitter loading into synaptic vesicles, indicating a cluster of proteins that function primarily in moving substances across membranes and packaging into vesicles. This is a coherent, substrate-diverse transport theme rather than a single metabolic pathway.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":6},{"id":"GO:0035725","count":5},{"id":"GO:0006855","count":5},{"id":"GO:0006004","count":5},{"id":"GO:0015751","count":5}]},{"hash":"1331242720894984874","title":"Antiviral Immune Signaling with Mechanosensing","description":"The cluster is enriched for antiviral/immune terms (type I interferon production, defense response to virus, regulation of TLR signaling) together with responses to mechanical stimuli (cellular response to mechanical stimulus, response to muscle stretch). A transcription-related term (DNA-templated transcription) plus other regulatory terms suggests broader transcriptional control accompanying these processes, supporting a theme of immune signaling intertwined with mechanosensitive regulation.","confidence":"Medium","size":28,"edges":12,"triangles":1,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0045351","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0002268","count":3}]},{"hash":"2151813862821160783","title":"Signaling and cytoskeletal dynamics","description":"GO terms indicate involvement in diverse signaling pathways (small GTPase-mediated signal transduction; PI3K/AKT signaling; insulin signaling regulation) and processes tied to cytoskeletal rearrangement and movement (microtubule-based movement, cell migration, response to mechanical stimulus). This pattern points to a cluster of proteins that coordinate growth signaling with cytoskeletal dynamics to drive cell motility, rather than a single linear pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0071260","count":2}]},{"hash":"725856768986266436","title":"P450-Mediated Steroid Biosynthesis","description":"The GO terms are dominated by steroid/hormone biosynthesis processes across species (ecdysone, aldosterone, bile acids, brassinosteroids) and by omega-hydroxylase P450 activity, indicating cytochrome P450 enzymes driving steroid metabolism. While some development or stress-response terms appear, the shared theme is P450-catalyzed steroid biosynthesis and related oxidative metabolism, which justifies a single cluster label.","confidence":"High","size":28,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006697","count":28},{"id":"GO:0097267","count":28},{"id":"GO:0032342","count":28},{"id":"GO:0071615","count":28},{"id":"GO:0006699","count":28}]},{"hash":"76977265787322980","title":"Innate Immune Response and Inflammation","description":"The cluster is enriched for GO terms tied to innate immunity and inflammatory signaling: innate immune response, inflammatory response, defense response to Gram-positive bacteria, response to dsRNA, LPS-mediated signaling, and interferon-beta production. These collectively point to pathogen sensing and cytokine-mediated defense. A few terms (e.g., regulation of Rho signaling) relate to cytoskeletal changes in immune contexts, and a term like cellular response to chloroquine is a more situational cue but does not override the overarching immune theme. Therefore, the most representative label is Innate Immune Response and Inflammation with Medium confidence.","confidence":"Medium","size":28,"edges":14,"triangles":1,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0016525","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0045359","count":4}]},{"hash":"590473608942500026","title":"Ribosome biogenesis and translation with ER stress","description":"Top GO terms are dominated by ribosome biogenesis (GO:0042254) and cytoplasmic translation (GO:0002181), with related rRNA processing and maturation steps (GO:0070475, GO:0000463) and cell division (GO:0051301). The presence of ER organization and ER overload response (GO:0007029, GO:0006983) and ubiquitin-dependent ERAD pathway suggests coupling between ribosome-related protein synthesis/assembly and ER quality control. A Pol III transcription regulation term (GO:0045945) may reflect coordinated expression of tRNAs and rRNA components. Taken together, the cluster appears to represent a network of proteins coordinating ribosome biogenesis and translation, with secondary involvement in ER stress responses.","confidence":"High","size":28,"edges":65,"triangles":20,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0045945","count":2},{"id":"GO:0007029","count":1}]},{"hash":"1590761696648969794","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":92,"triangles":76,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001682","count":3},{"id":"GO:0016310","count":2},{"id":"GO:0009089","count":2},{"id":"GO:0019877","count":2},{"id":"GO:1905267","count":2}]},{"hash":"1517930832013887122","title":"Lipid and xenobiotic metabolism with detoxification","description":"This cluster centers on catabolic and detoxification processes spanning lipids and various xenobiotics, including triglyceride and phospholipid catabolism, oxidation-reduction and oxidant detoxification, and responses to toxic substances. The presence of endocannabinoid signaling regulation further ties to lipid signaling. Overall, the proteins appear to function in broad metabolic and detox pathways.","confidence":"Medium","size":28,"edges":60,"triangles":34,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0019433","count":18},{"id":"GO:0055114","count":15},{"id":"GO:2000124","count":13},{"id":"GO:0006212","count":13},{"id":"GO:0019380","count":13}]},{"hash":"2123719041772977916","title":"NF-kappaB-mediated inflammatory signaling","description":"These proteins cluster around immune/inflammatory signaling: multiple GO terms point to NF-kappaB pathway (canonical NF-kappaB signal transduction, positive regulation of canonical NF-kappaB signaling), inflammatory response, IL-1 and IL-17 signaling, and the JNK cascade, as well as B cell apoptotic processes. The shared theme is activation of inflammatory responses via NF-kappaB/JNK axes. Therefore this cluster is best labeled NF-kappaB-mediated inflammatory signaling.","confidence":"High","size":28,"edges":5,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006919","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0070555","count":3},{"id":"GO:0006954","count":3}]},{"hash":"1274713979996172820","title":"Bacterial lipid A/LPS biosynthesis and methylation","description":"This cluster is strongly enriched for lipid A and lipopolysaccharide biosynthetic processes, plus methylation-related terms (protein methylation, methylation). These indicate a bacterial metabolic/biosynthetic module with methyltransferase activities; the presence of antibiotic response and several biosynthetic pathways (cobalamin, coumarin) supports a broad metabolic cluster typical of bacterial cell envelope and related metabolism. Some dopamine-related terms are less central but may reflect peripheral regulatory or catabolic capabilities in certain bacteria, not altering the main theme. Confidence: Medium.","confidence":"","size":27,"edges":336,"triangles":2583,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046677","count":8},{"id":"GO:0032259","count":7},{"id":"GO:0006223","count":6},{"id":"GO:0009245","count":6},{"id":"GO:0009103","count":6}]},{"hash":"1654013555126627599","title":"Cardiac Electrophysiology and Retina Development","description":"Based on the GO terms, the cluster centers on cardiac electrical activity\u2014SA node action potential, atrial/ventricular depolarization and repolarization, and regulation of heart rate\u2014indicating cardiac electrophysiology as the core function. Retina-related terms (visual perception, retina vasculature development) and melanosome transport appear as secondary associations, suggesting some shared or pleiotropic roles in retinal cells but not a dominant theme. Therefore, the primary label reflects heart rhythm and conduction with a secondary eye development angle.","confidence":"Medium","size":27,"edges":25,"triangles":10,"max_degree":5,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0086091","count":7},{"id":"GO:0007601","count":6},{"id":"GO:0035646","count":6},{"id":"GO:0060307","count":6},{"id":"GO:0060371","count":6}]},{"hash":"1743170248060282544","title":"GTPase Signaling and Cell Polarity","description":"The set centers on small GTPase\u2013mediated signal transduction and regulation of GTPase activity, coupled with establishment/maintenance of cytoskeleton polarity and epithelial cell polarity. Additional terms for GPCR-related cAMP signaling and dopamine receptor pathways support a broader theme of signaling intertwined with cytoskeletal organization. Although a few terms reflect diverse developmental contexts (heart, retina, ascospore formation), the dominant pattern ties GTPase signaling to polarity and cytoskeletal dynamics.","confidence":"Medium","size":27,"edges":169,"triangles":731,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":20},{"id":"GO:0043547","count":20},{"id":"GO:0030437","count":18},{"id":"GO:0046549","count":18},{"id":"GO:0043950","count":18}]},{"hash":"940980985217154661","title":"Hearing and neural signaling","description":"This cluster is dominated by GO terms for cochlea development and sensory perception of sound, plus neural signaling processes such as sodium ion transport and transmission of nerve impulses, and serotonin receptor signaling. While there are ancillary terms related to heart rate regulation and muscle growth, the strongest common thread among the proteins appears to be involvement in auditory system development and neural communication.","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0001988","count":27},{"id":"GO:2001226","count":27},{"id":"GO:0035725","count":27},{"id":"GO:0051970","count":27},{"id":"GO:0090102","count":27}]},{"hash":"1837777081822183791","title":"Neural development and axon guidance","description":"The top terms cluster around nervous system development and axon guidance, including axonal fasciculation, synapse assembly, semaphorin-plexin signaling, and various neuron projection guidance terms (ventral trunk neural crest migration, branchiomotor, sympathetic innervation, trigeminal nerve organization). Ossification and innate immune response are less central. Overall, the proteins seem to participate in neural development and guiding axons to their targets.","confidence":"High","size":27,"edges":55,"triangles":24,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":8},{"id":"GO:0051965","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0036486","count":7},{"id":"GO:0007399","count":7}]},{"hash":"1028453916681493602","title":"Mitochondrial maintenance and organogenesis","description":"This cluster centers on mitochondrial quality/assembly (complex IV assembly, mitophagy) alongside developmental processes (kidney development, odontogenesis) and tissue organization (cell-matrix adhesion). The presence of neuron apoptosis regulation terms adds regulatory context but the dominant themes are mitochondrial maintenance and tissue organogenesis.","confidence":"Medium","size":27,"edges":10,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030218","count":3},{"id":"GO:0055072","count":3},{"id":"GO:0033617","count":3},{"id":"GO:0000422","count":2},{"id":"GO:0043280","count":2}]},{"hash":"1029137207353570348","title":"Developmental cell polarity and secretory trafficking","description":"The top GO terms span developmental processes (megakaryocyte differentiation, coronary artery morphogenesis, lumen formation, planar polarity) and secretory pathway activity (ER to Golgi transport), with supporting roles for cytoskeletal changes and lipid homeostasis. This suggests a cohesive theme around how developing tissues organize cells and membranes, rather than a single specific pathway. ","confidence":"Medium","size":27,"edges":291,"triangles":1959,"max_degree":25,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0045654","count":7},{"id":"GO:0060982","count":7},{"id":"GO:1990000","count":7},{"id":"GO:0032876","count":7},{"id":"GO:0006888","count":7}]},{"hash":"834235922306005601","title":"Neural development and dendritic spine morphogenesis","description":"The cluster is strongly enriched for neural development and synaptic formation terms, including dendritic spine morphogenesis, neural tube closure, and multicellular organism development, together with transcriptional regulation and microtubule-related protein localization. These points together suggest a cohesive role in neural development and spine formation; ancillary terms like innate immune response and angiogenesis may reflect broader developmental contexts but do not override the central neural-development theme.","confidence":"High","size":27,"edges":61,"triangles":48,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048148","count":21},{"id":"GO:0060997","count":21},{"id":"GO:0007275","count":21},{"id":"GO:0001843","count":20},{"id":"GO:0006351","count":19}]},{"hash":"1608166554912195523","title":"Extracellular matrix assembly and tissue morphogenesis","description":"This cluster is dominated by GO terms for collagen biosynthesis, basement membrane/nephrodevelopment, cartilage and skin morphogenesis, and cell adhesion, all pointing to extracellular matrix construction and connective tissue development. Additional terms for lymphangiogenesis and glomerular basement membrane support tissue remodeling roles. The voltage-gated sodium channel clustering term is less central. Overall, ECM and tissue morphogenesis best explain the group.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045162","count":8},{"id":"GO:0006958","count":8},{"id":"GO:0060351","count":8},{"id":"GO:0032836","count":8},{"id":"GO:0007155","count":8}]},{"hash":"999435292176203630","title":"Endosome-to-Golgi/Lysosome Transport","description":"The cluster is enriched for several endomembrane transport steps, notably endosome-to-Golgi and endosome-to-lysosome routes, plus endosome maturation from early to late, and plasma membrane-to-endosome trafficking, with additional signals for Rab, Rap, and Rho regulation and plus-end\u2013directed transport along microtubules, indicating a cohesive vesicle trafficking module in the endomembrane system.","confidence":"High","size":27,"edges":26,"triangles":5,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0034499","count":3},{"id":"GO:0008333","count":3},{"id":"GO:0045022","count":3},{"id":"GO:0045053","count":2},{"id":"GO:0035023","count":2}]},{"hash":"777148587232773399","title":"Neural and craniofacial development signaling","description":"Top GO terms point to transcriptional regulation (DNA-templated transcription) and signaling (peptidyl-tyrosine phosphorylation) governing development. The presence of cerebral cortex development and embryonic cranial skeleton morphogenesis highlights neural and craniofacial patterning, while thyroid gland development expands to head/neck development. Additional terms like Rho signaling and protein localization to synapse reflect cytoskeletal dynamics and neural differentiation. Together, these processes suggest a module of proteins coordinating transcription, signaling, and cell-cycle control during head and neural development.","confidence":"High","size":27,"edges":73,"triangles":83,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":17},{"id":"GO:0018108","count":17},{"id":"GO:0000278","count":16},{"id":"GO:0021987","count":15},{"id":"GO:0008285","count":15}]},{"hash":"1851212688630864589","title":"Craniofacial skeletal development and palatogenesis","description":"This cluster centers on cartilage and bone formation in the craniofacial region, with terms like chondrocyte differentiation, osteoblast differentiation, bone regeneration, and roof of mouth development (palatogenesis). The BMP signaling and broader multicellular development terms support morphogenesis of craniofacial structures, while stress fiber assembly hints at cytoskeletal changes during differentiation. Overall, it coherently points to coordinated skeletal and craniofacial development.","confidence":"High","size":27,"edges":233,"triangles":1317,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002062","count":7},{"id":"GO:0060716","count":7},{"id":"GO:0051496","count":7},{"id":"GO:0030514","count":6},{"id":"GO:0007275","count":6}]},{"hash":"1254075956126072463","title":"Cytoskeleton-driven vesicle docking and polarized growth","description":"The top GO terms center on actin cortical patch assembly, vesicle docking in exocytosis, and budding cell apical bud growth, which together point to a module of cytoskeleton dynamics governing polarized growth and vesicle trafficking. Supporting terms like mitochondrial inheritance and regulatory processes (proteasomal regulation, apoptosis, Wnt signaling, and RNA processing) suggest broader cellular maintenance and gene-expression regulation linked to this core transport/polarity machinery. Overall, the label captures the central theme of cytoskeleton-associated vesicle trafficking driving polarized growth, with related regulatory processes. ","confidence":"Medium","size":27,"edges":154,"triangles":397,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009636","count":4},{"id":"GO:0000147","count":4},{"id":"GO:0007118","count":4},{"id":"GO:0006904","count":4},{"id":"GO:0000001","count":4}]},{"hash":"1839274447301475927","title":"Bone ECM Remodeling and Angiogenesis","description":"The cluster centers on extracellular matrix processes (collagen fibril organization, elastic fiber assembly, cell-matrix adhesion) and angiogenesis (positive/negative regulation), with osteoblast proliferation regulation supporting a bone remodeling context. Inflammatory signals (IL-1 response) and complement activation further suggest a remodeling environment influenced by immune signaling. This combination points to coordinated bone matrix remodeling and vascularization as the core theme.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0033689","count":8},{"id":"GO:0071347","count":7},{"id":"GO:0030199","count":7},{"id":"GO:0045766","count":7},{"id":"GO:1902042","count":7}]},{"hash":"589065156872468792","title":"Embryonic Organogenesis and Neural Development","description":"The top GO terms span brain/forebrain development, neural crest cell migration, cardiac muscle differentiation, and digestive tract/uterus development, indicating broad organogenesis and tissue differentiation rather than a single pathway. Rho signaling and actin cytoskeleton reorganization further tie to cell movement and morphogenesis, supporting a developmental, multi-tissue theme for this cluster.","confidence":"Medium","size":27,"edges":27,"triangles":6,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:2000727","count":7},{"id":"GO:0060065","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0030900","count":7},{"id":"GO:0010667","count":6}]},{"hash":"1158803939121134299","title":"Embryonic Patterning and Organogenesis","description":"The cluster\u2019s top GO terms cluster around embryonic development and tissue morphogenesis, including left/right pattern formation, endocrine system development, endocardial cushion EMT, cartilage morphogenesis, trophoblast differentiation, and pancreatic cell development. Together these point to proteins involved in early development and organ formation, with a secondary presence of general transcription or ribosome-related terms likely representing broader cellular functions. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":12},{"id":"GO:0035270","count":12},{"id":"GO:0003198","count":12},{"id":"GO:0060806","count":12},{"id":"GO:0060536","count":12}]},{"hash":"1813774882432929189","title":"Complement-Driven innate immune and coagulation responses","description":"The cluster shows strong enrichment for innate immune and coagulation GO terms: classical complement activation, defense response to Gram-positive bacteria, response to lipopolysaccharide, and blood coagulation, indicating a coherent immune/coagulation module. Developmental terms are present but appear less central to the cluster\u2019s core function.","confidence":"High","size":27,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":20},{"id":"GO:0006958","count":20},{"id":"GO:0071333","count":19},{"id":"GO:0050830","count":19},{"id":"GO:0045766","count":19}]},{"hash":"1464109778947118036","title":"Neural Signaling and Sensory Perception","description":"This cluster shows enrichment for neural-related GO terms: detection of light stimulus, visual perception, memory, GPCR signaling, and cellular responses to electrical stimuli, plus brain-associated maturation (pons). Ion transport and electron transport chain terms can underlie neuronal energetics, supporting a neural signaling theme, though a few terms (e.g., oocyte maturation regulation, fungicide response) are outliers.","confidence":"Medium","size":27,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":27},{"id":"GO:0035725","count":27},{"id":"GO:0030818","count":27},{"id":"GO:0060992","count":27},{"id":"GO:0022900","count":27}]},{"hash":"35134234673798890","title":"Neuromuscular development and synapse regulation","description":"These proteins show enrichment for skeletal muscle differentiation and muscle fiber development, CNS development, and synapse-related processes (innervation, synaptic vesicle endocytosis). The combination of muscle and neural development terms, along with regulatory and proteolytic processes, points to a coordinated role in neuromuscular development and synapse regulation rather than a single isolated pathway.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":4},{"id":"GO:0007417","count":3},{"id":"GO:0030514","count":3},{"id":"GO:0071276","count":2},{"id":"GO:0000083","count":2}]},{"hash":"1413572157643761272","title":"Stress-related mRNA processing and translation initiation","description":"The cluster centers on post-transcriptional regulation: splicing control via the spliceosome (positive, negative, and alternative), stress-responsive regulation of mRNA stability, and translation initiation processes (preinitiation complex formation and IRES-dependent initiation), with supporting regulatory ncRNA\u2013mediated gene silencing.","confidence":"High","size":27,"edges":116,"triangles":209,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":22},{"id":"GO:0048025","count":21},{"id":"GO:0006378","count":17},{"id":"GO:0075522","count":17},{"id":"GO:0000381","count":16}]},{"hash":"692393086264715221","title":"PI3K-AKT signaling in neural development and apoptosis","description":"The cluster is enriched for PI3K/PKB signaling terms (GO:0043491, GO:0048015) and related insulin signaling via PI3K (GO:0038028), suggesting a phosphoinositide signaling core. It also includes brain development (GO:0007420) and regulation of apoptotic processes (GO:0043065, GO:0034351), and mentions synaptic plasticity regulation, indicating a neural context focused on neuronal survival and plasticity. Although several terms are obsolete, the pattern points to PI3K-AKT\u2013mediated signaling influencing brain development and apoptosis, making this a cohesive neural signaling cluster.","confidence":"Medium","size":27,"edges":8,"triangles":1,"max_degree":5,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043491","count":5},{"id":"GO:0038028","count":5},{"id":"GO:0043065","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0048015","count":5}]},{"hash":"1267306501840895876","title":"Neuronal cell adhesion and synapse development","description":"The dominant GO terms point to cell\u2013cell adhesion in neural contexts (homophilic/heterophilic adhesion, neuron-specific adhesion, cadherin-mediated adhesion) and nervous system development, with a focus on synapse assembly. While there are a couple of broader terms (bone maturation, melanin biosynthesis) they are less central to the cluster\u2019s core signal. This makes a concise label centered on neuronal adhesion and synapse formation most representative. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":20},{"id":"GO:0007399","count":19},{"id":"GO:0051965","count":19},{"id":"GO:0007158","count":17},{"id":"GO:0043931","count":15}]},{"hash":"1979718049950178111","title":"Neuronal development and ER-stress\u2013related apoptosis","description":"This cluster is enriched for cerebral cortex and corpus callosum development, axon regeneration, and neuronal development terms, alongside intrinsic apoptotic signaling and negative regulation of JNK signaling under ER stress, suggesting a group of neural development proteins tied to stress-induced apoptosis pathways.","confidence":"High","size":27,"edges":186,"triangles":575,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":27},{"id":"GO:0070059","count":27},{"id":"GO:0046329","count":27},{"id":"GO:0072428","count":27},{"id":"GO:0021987","count":27}]},{"hash":"1105359552206867748","title":"Neural development and synapse assembly with ECM adhesion","description":"This cluster centers on neuronal development and synapse assembly, highlighted by positive regulation of synapse formation, neuron differentiation, and axon guidance. It also emphasizes cell adhesion and integrin signaling, with extracellular matrix involvement (collagen fibril organization). The presence of a complement activation term may reflect synaptic remodeling. Taken together, the proteins likely function in neural development and synapse formation within an ECM/adhesion context.","confidence":"Medium","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":8},{"id":"GO:0006958","count":8},{"id":"GO:0030199","count":8},{"id":"GO:0032331","count":7},{"id":"GO:2001027","count":7}]},{"hash":"1756557327291264210","title":"Fatty acid oxidation and branched-chain amino acid catabolism","description":"The GO terms strongly point to beta-oxidation pathways, including long-chain fatty acid catabolism, acyl-CoA oxidase activity, and carnitine metabolism, along with catabolism of valine and leucine. This suggests a core metabolic theme centered on fatty acid oxidation and branched-chain amino acid breakdown. Some terms (e.g., ascaroside biosynthesis, development) may reflect peroxisomal links to signaling and developmental regulation, but the dominant signal is energy production via fatty acid and BCAA catabolism.","confidence":"Medium","size":27,"edges":250,"triangles":1222,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":7},{"id":"GO:0055114","count":6},{"id":"GO:0009791","count":5},{"id":"GO:0033540","count":5},{"id":"GO:1904070","count":5}]},{"hash":"1209599107120090942","title":"Embryonic Development and Tissue Patterning","description":"This cluster\u2019s GO terms cover neural development (axon guidance, neuron specification) alongside diverse organ development (muscle, pancreas, ureteric branching, uterine epithelium) and signaling processes (ERK cascade, cell-matrix adhesion). The common thread is developmental patterning across multiple tissues, rather than a single specific function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":3},{"id":"GO:0021520","count":3},{"id":"GO:0007519","count":3},{"id":"GO:0031018","count":3},{"id":"GO:0090190","count":3}]},{"hash":"2290907396721652759","title":"Embryonic Organ Morphogenesis","description":"This cluster centers on genes involved in embryonic development and tissue morphogenesis across multiple organs (eye, heart, hindlimb, placenta, gonads, habenula, prostate, etc.), with concurrent transcriptional regulation processes, indicating a module of regulators guiding organ formation and tissue-specific morphogenesis during development.","confidence":"High","size":27,"edges":199,"triangles":868,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":12},{"id":"GO:0006366","count":10},{"id":"GO:0006351","count":10},{"id":"GO:0007507","count":9},{"id":"GO:0035116","count":9}]},{"hash":"2009814631476392574","title":"Neural and inner ear development with synaptic adhesion","description":"The cluster is dominated by GO terms for nervous system development, synapse assembly, and neuron cell-cell adhesion, with strong signals for inner ear development and sensory perception of sound, indicating a cohesive theme of neural/ear development and synaptic connectivity.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0007156","count":11},{"id":"GO:0043931","count":11},{"id":"GO:0007157","count":10}]},{"hash":"1530497900780987552","title":"Unknown","description":"The GO terms include DNA repair, apoptotic regulation, myoblast fusion, synaptic signaling, vesicle transport, and several nucleotide and snoRNA catabolic processes, which do not point to a single cohesive function. This diversity suggests no clear common theme, so the cluster is best labeled Unknown with no confidence.","confidence":"","size":27,"edges":9,"triangles":0,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0048227","count":2}]},{"hash":"2242823481413850653","title":"Centrosome localization and microtubule-mediated trafficking","description":"These proteins show a cohesive theme around the centrosome and microtubule-based processes: centrosome localization, microtubule anchoring at the MTOC, minus-end-directed organelle transport along microtubules, and Golgi localization/endocytosis. The inclusion of stress granule assembly suggests broader cytoskeletal and RNA-protein complex interactions. Overall, the cluster represents centrosome/microtubule organization with associated organelle trafficking and granule dynamics.","confidence":"High","size":27,"edges":9,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051642","count":4},{"id":"GO:0034063","count":3},{"id":"GO:0000042","count":3},{"id":"GO:1900737","count":3},{"id":"GO:1900276","count":3}]},{"hash":"653079386608016388","title":"Craniofacial bone development and neural synapse formation","description":"The cluster shows strong enrichment for cell adhesion terms (homophilic/heterophilic adhesion) alongside neural development signals (nervous system development, synaptic transmission, glutamatergic signaling) and bone morphogenesis (ossification, cranial skeleton morphogenesis, BMP signaling). This combination points to proteins involved in craniofacial bone formation and the development/formation of neural synapses, consistent with both skeletal and neural development pathways.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0043931","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0007399","count":9}]},{"hash":"33101474189334838","title":"Developmental Signaling and Glycosylation","description":"This cluster centers on developmental signaling terms (heart and nervous system development; B cell receptor signaling; Roundabout signaling) with supporting notes on protein regulation and glycosylation/metabolic processes (ubiquitin-dependent proteolysis, deglycosylation, N-acetylglucosamine and carbohydrate metabolism). The shared theme appears to be signaling and regulatory mechanisms during development, with some contributions from post-translational modification pathways, so the label is a reasonable, moderately confident summary.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0042787","count":3}]},{"hash":"384623382463379013","title":"Embryonic patterning and organ morphogenesis","description":"These proteins are enriched for GO terms centered on developmental patterning and morphogenesis, including left-right patterning, endocrine system development, epithelial-to-mesenchymal transition in heart development, cartilage morphogenesis, placenta and hair follicle morphogenesis, and related embryonic organogenesis processes. The common thread is embryonic tissue patterning and organ formation, making this a cohesive developmental cluster.","confidence":"High","size":27,"edges":5,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":19},{"id":"GO:0035270","count":19},{"id":"GO:0003198","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0060536","count":19}]},{"hash":"1489951851611110817","title":"Pancreatic beta-cell development and insulin secretion","description":"The top terms converge on pancreas development and insulin secretion in response to glucose, with a related emphasis on PPAR signaling, pointing to pancreatic beta-cell function and metabolic regulation. Some terms appear to reflect broader housekeeping processes (ER maintenance, DNA maintenance) that may not define the cluster\u2019s core function, so the label emphasizes the pancreatic insulin axis as the defining theme. ","confidence":"Medium","size":27,"edges":17,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035360","count":2},{"id":"GO:0031016","count":2},{"id":"GO:0035773","count":2},{"id":"GO:0051685","count":1},{"id":"GO:2000042","count":1}]},{"hash":"878070438887544575","title":"Vertebrate organ morphogenesis","description":"The top GO terms cluster around vertebrate organ development and morphogenesis, including branching morphogenesis (ureteric bud), inner ear formation, endocrine pancreas development, neural crest migration, digestive tract morphogenesis, cranial skeleton formation, and development of the pituitary and thyroid glands. The presence of broad developmental terms and a regulatory transcription term suggests these proteins coordinate organogenesis and tissue patterning. Overall, the cluster represents vertebrate organogenesis and morphogenesis.","confidence":"High","size":27,"edges":349,"triangles":2875,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090190","count":16},{"id":"GO:0000122","count":16},{"id":"GO:0048839","count":15},{"id":"GO:0031018","count":15},{"id":"GO:0001755","count":15}]},{"hash":"2281439048609653853","title":"Embryonic patterning and organ morphogenesis","description":"The cluster's top GO terms are dominated by embryonic development and tissue morphogenesis, including left-right pattern formation, endocrine system development, heart cushion EMT, cartilage morphogenesis, placenta development, trophoblast differentiation, and pancreatic cell development. This suggests a coherent theme of embryogenesis and organ formation; secondary terms related to transcription and ribosome export reflect general cellular activity in developing cells rather than unrelated processes.","confidence":"High","size":27,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":21},{"id":"GO:0035270","count":21},{"id":"GO:0003198","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0060536","count":21}]},{"hash":"1054804087540600035","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms for translation and ribosome assembly\u2014translation, translational initiation/termination, cytoplasmic translation, ribosome biogenesis, and large subunit assembly\u2014plus RNA modification/processing steps (pseudouridine synthesis in rRNA/snRNA and ITS1 rRNA processing) tied to ribosome maturation. The antibiotic response term may reflect translation-targeted stress responses, but overall the data point to a cohesive ribosome/translation machinery cluster.","confidence":"High","size":27,"edges":337,"triangles":2618,"max_degree":26,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":17},{"id":"GO:0046677","count":5},{"id":"GO:0006415","count":4},{"id":"GO:0000027","count":4},{"id":"GO:0002181","count":4}]},{"hash":"727926535096179318","title":"Dopaminergic Signaling and Neurodevelopment","description":"Most terms are about nervous system development and signaling, especially dopaminergic synaptic transmission, neuropeptide signaling, and regulation of dopamine receptors, which suggests proteins involved in neuronal signaling and dopamine pathways. Some terms (saliva secretion, metanephric glomerulus development) are outliers, but the dominant theme points to neural signaling and development.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":27},{"id":"GO:0072224","count":27},{"id":"GO:0060160","count":27},{"id":"GO:0048484","count":27},{"id":"GO:2000458","count":27}]},{"hash":"774917370146275376","title":"Neuropeptide signaling and dopaminergic nervous system","description":"The terms are dominated by nervous system functions: neuropeptide signaling, dopaminergic synaptic transmission, dopamine receptor signaling, sensory perception of pain, grooming behavior, and various nervous system development terms. While a couple of terms (saliva secretion, metanephric glomerulus development) are non-neural, they may reflect broad GO annotations, but the core theme points to neural signaling and development centered on dopamine and neuropeptides.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":27},{"id":"GO:0072224","count":27},{"id":"GO:0060160","count":27},{"id":"GO:0048484","count":27},{"id":"GO:2000458","count":27}]},{"hash":"439631851309045935","title":"Mitochondrial apoptosis and calcium homeostasis","description":"The cluster features multiple GO terms tied to apoptosis regulation (intrinsic apoptotic signaling via p53, extrinsic apoptotic signaling, anoikis) and mitochondrial/ER processes (protein insertion into mitochondrial inner membrane, ER calcium homeostasis, calcium ion transport regulation). This suggests a cohesive theme around mitochondrial-mediated apoptotic control and associated calcium signaling under stress, with some related cell-cycle regulation signals. Confidence: High","confidence":"","size":26,"edges":83,"triangles":85,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0090005","count":3},{"id":"GO:0010523","count":3},{"id":"GO:1902042","count":3},{"id":"GO:0042149","count":3},{"id":"GO:2000134","count":3}]},{"hash":"1011083329184812518","title":"Redox Homeostasis and Oxidative Stress Response","description":"The cluster is dominated by GO terms related to cellular redox balance, oxidant detoxification, and responses to oxidative stress, including deglutathionylation. These themes suggest a core function in maintaining redox homeostasis and defending against oxidative damage, despite some outlier terms. ","confidence":"High","size":26,"edges":288,"triangles":1927,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":23},{"id":"GO:0098869","count":22},{"id":"GO:0055114","count":20},{"id":"GO:0034599","count":18},{"id":"GO:1903026","count":18}]},{"hash":"131134117326938085","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":104,"triangles":171,"max_degree":15,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006207","count":6},{"id":"GO:0044205","count":6},{"id":"GO:0001822","count":5},{"id":"GO:0045312","count":5},{"id":"GO:1902269","count":5}]},{"hash":"1459987850960650985","title":"Neuroinflammation and Synaptic Plasticity","description":"The presence of strong NF-kB\u2013related immune terms (positive regulation of canonical NF-kappaB signal transduction; innate immune response) together with neuronal and plasticity-related terms (long-term synaptic potentiation; substantia nigra development) and stress/toxin response terms (response to xenobiotic stimulus, methylmercury, hypoxia) suggests these proteins participate in neuroinflammatory signaling that modulates neuronal function and stress responses.","confidence":"Medium","size":26,"edges":20,"triangles":2,"max_degree":5,"top_function":"wound healing","top_go_terms":[{"id":"GO:0043123","count":13},{"id":"GO:0045087","count":11},{"id":"GO:0051092","count":9},{"id":"GO:0042493","count":9},{"id":"GO:0030593","count":8}]},{"hash":"761216026210166760","title":"Heavy Metal Detoxification and Xenobiotic Transport","description":"The cluster\u2019s terms cluster around metal detoxification and membrane transport: cadmium and mercury ion import into vacuole, phytochelatin import into vacuole, cellular detoxification of cadmium ion, xenobiotic transmembrane transport, and related ion-channel/transport activities. This suggests a cohesive role in sequestration and efflux of heavy metals and xenobiotics via vacuolar transport and membrane processes, with supporting membrane potential changes. ","confidence":"High","size":26,"edges":89,"triangles":156,"max_degree":13,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0045332","count":13},{"id":"GO:1902943","count":9},{"id":"GO:0006855","count":9},{"id":"GO:0036246","count":9},{"id":"GO:0046689","count":9}]},{"hash":"862207861042331633","title":"Inflammatory Cytokine Secretion and ER-Golgi Organization","description":"Strong enrichment for inflammatory cytokine production (IL-1\u03b2, IL-18), interferon response, and glial differentiation, together with GO terms for endoplasmic reticulum and Golgi organization, points to a module centered on cytokine synthesis/secretion via the secretory pathway.","confidence":"High","size":26,"edges":32,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0007029","count":3},{"id":"GO:1900017","count":3},{"id":"GO:0045687","count":3},{"id":"GO:0007030","count":3}]},{"hash":"500025411814256462","title":"Hormone-responsive brain development and angiogenesis signaling","description":"The top GO terms point to hormone responses (estradiol, vitamin D) and growth-related signaling (positive regulation of PI3K and MAPK cascades) with a thread of angiogenesis regulation and brain development, suggesting a theme around hormone-driven signaling in neural development and vascular growth. The presence of virus defense is a peripheral note, but the dominant pattern centers on signaling pathways linked to development and angiogenesis. Therefore the label captures the core functional theme of the cluster.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0032355","count":3}]},{"hash":"1674553918302283566","title":"Neural development and synaptic function","description":"The top GO terms cluster around brain development, neural plate axis specification, and synaptic processes (synapse assembly, neurotransmitter secretion), pointing to roles in neural patterning and synaptic function. The presence of PI3K/AKT signaling and apoptotic regulation suggests signaling and survival mechanisms in neural cells, while negative regulation of angiogenesis may reflect neurovascular interactions during development. Together these terms indicate a neural-development/synaptic-function theme.","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0045945","count":3},{"id":"GO:0051897","count":3}]},{"hash":"1000556469422326849","title":"GTPase Signaling and Cytoskeleton Remodeling","description":"The top GO terms cluster around small GTPase activity and its regulation, including small GTPase-mediated signal transduction and positive regulation of GTPase activity, as well as calcium-dependent exocytosis. This points to a functional theme of signaling linked to membrane trafficking and cytoskeletal dynamics driving cell migration and dendritic spine development. A few items (lipoprotein assembly and certain apoptotic processes) are ancillary outliers, but the core signal relates to GTPase-driven regulation of movement and exocytosis.","confidence":"Medium","size":26,"edges":236,"triangles":1213,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045956","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0034379","count":4}]},{"hash":"1914320062840603337","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"These proteins cluster around actin dynamics and motility (lamellipodium assembly, actin crosslinking, Rho signaling, cell migration, phagocytosis) with supporting immune signaling and developmental terms that reflect cytoskeletal roles in immune cell functions and tissue remodeling. Overall, the theme is actin-driven cytoskeleton remodeling enabling movement.","confidence":"High","size":26,"edges":114,"triangles":377,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016477","count":7},{"id":"GO:0030032","count":7},{"id":"GO:0050853","count":7},{"id":"GO:0090557","count":6},{"id":"GO:0043552","count":6}]},{"hash":"315728571224928222","title":"Developmental signaling pathway regulation","description":"These proteins appear to regulate signaling during development across tissues, aligning with terms for muscle differentiation, heart formation, and CNS development, while also repeatedly noting negative regulation of BMP, Wnt, activin, and PI3K/Akt pathways. The cluster seems driven by a theme of tuning developmental signals rather than a single tissue-specific function.","confidence":"High","size":26,"edges":290,"triangles":1916,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":6},{"id":"GO:0046827","count":6},{"id":"GO:1905456","count":5},{"id":"GO:0060914","count":5},{"id":"GO:0070197","count":5}]},{"hash":"1451995201403844896","title":"Ubiquitin-Proteasome System and Circadian Regulation","description":"The cluster centers on ubiquitin-dependent protein catabolism (SCF-dependent proteasomal degradation, ERAD) and glycoprotein turnover, with a strong signal for regulation of circadian rhythm. This suggests a proteostasis module linked to temporal control, also touching on stress responses (cadmium, oxidative stress) and neural development signals. ","confidence":"High","size":26,"edges":214,"triangles":1278,"max_degree":22,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0042787","count":25},{"id":"GO:0042752","count":23},{"id":"GO:0031146","count":22},{"id":"GO:0006516","count":21},{"id":"GO:1903378","count":21}]},{"hash":"281796289015406718","title":"Multisystem embryonic organogenesis and neural crest development","description":"The cluster\u2019s top GO terms cluster around embryonic development across multiple organs and tissues, including kidney branching, hypothalamus and brain regions, craniofacial structures (roof of mouth, odontogenesis), neural crest\u2013mediated migration, and endocrine pancreas/digestive tract morphogenesis. This suggests a shared theme of early organ formation and neural crest\u2013related differentiation, justifying a label that reflects multisystem embryonic organogenesis with emphasis on neural crest\u2013derived structures.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090190","count":20},{"id":"GO:0021986","count":19},{"id":"GO:0031018","count":19},{"id":"GO:0000122","count":19},{"id":"GO:0001755","count":19}]},{"hash":"1314092982787238785","title":"Epigenetic Chromatin Silencing","description":"The cluster is dominated by histone modification and heterochromatin terms (H3/H4 methylation marks and rDNA heterochromatin formation), indicating regulation of chromatin state and gene silencing. While there are some related but broader terms (Notch signaling, DNA damage\u2013induced apoptosis), the strongest signal centers on epigenetic regulation via histone methylation and heterochromatin formation.","confidence":"High","size":26,"edges":16,"triangles":5,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031937","count":5},{"id":"GO:0034773","count":4},{"id":"GO:0045746","count":4},{"id":"GO:0080182","count":4},{"id":"GO:1902231","count":4}]},{"hash":"224882794023802795","title":"Developmental chromatin remodeling and transcription regulation","description":"The cluster is enriched for chromatin-associated processes (chromatin assembly/remodeling, nucleosome dynamics, histone methylation regulation, and heterochromatin formation) and transcriptional control (negative regulation of RNA Pol II), with additional links to development (vitellogenesis, muscle differentiation, growth). This pattern suggests proteins coordinating chromatin state to regulate gene expression during development, hence the chosen name.","confidence":"Medium","size":26,"edges":221,"triangles":1224,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":21},{"id":"GO:0007296","count":14},{"id":"GO:0006335","count":13},{"id":"GO:0045815","count":13},{"id":"GO:0042766","count":13}]},{"hash":"1846771641365087937","title":"Placental development and Wnt/ERK signaling","description":"The terms show a strong emphasis on placenta and labyrinthine layer development, indicating placental organogenesis, alongside signaling and growth control via the Wnt pathway and ERK cascade, with related cell cycle, transcription, and apoptotic processes. This pattern suggests proteins involved in placental development coordinated by Wnt/MAPK signaling and associated growth-survival pathways.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090263","count":24},{"id":"GO:0001890","count":23},{"id":"GO:0006351","count":23},{"id":"GO:0000278","count":23},{"id":"GO:0006915","count":23}]},{"hash":"2177832421794678101","title":"Neural Development and Ectoderm Formation","description":"This cluster is strongly enriched for neural development terms, including ventral spinal cord interneuron specification, spinal cord association neuron differentiation, motor neuron axon guidance, visceral motor neuron differentiation, and cerebellar Purkinje cell\u2013granule precursor signaling, along with ectoderm formation. While a few terms point to other embryonic processes like nephric duct elongation and female gonad development, the dominant theme is nervous system development and ectodermal lineage specification, suggesting a cohesive neural development theme for the cluster.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021521","count":25},{"id":"GO:0021527","count":25},{"id":"GO:0035847","count":25},{"id":"GO:0001705","count":25},{"id":"GO:0008045","count":25}]},{"hash":"901504107114009996","title":"Vesicle Priming and Exocytosis Signaling","description":"The top GO terms cluster around vesicle trafficking and exocytosis (synaptic vesicle priming, acrosome reaction, GPCR signaling, and related signaling regulation). While there are broader signaling terms (Ras/Rho regulation, IGF receptor signaling, vascular development), the common thread is signaling pathways that drive vesicle docking/fusion and regulated secretion, including neuronal and reproductive contexts.","confidence":"Medium","size":26,"edges":57,"triangles":34,"max_degree":11,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007213","count":15},{"id":"GO:0016082","count":15},{"id":"GO:0007340","count":15},{"id":"GO:0048009","count":15},{"id":"GO:0046580","count":15}]},{"hash":"763993403518817703","title":"Lung branching morphogenesis and ECM remodeling","description":"The cluster is dominated by GO terms tied to lung development and branching (epithelial tube and terminal unit subdivision in lung morphogenesis) together with extracellular matrix remodeling (basement membrane disassembly, collagen catabolic process, bone resorption) and associated signaling/localization (Wnt extracellular localization, thyroid hormone response). This pattern suggests a cohesive theme of lung morphogenesis driven by ECM turnover and developmental signaling, with secondary involvement of peptide catabolism and other signaling processes.","confidence":"High","size":26,"edges":255,"triangles":1482,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060441","count":17},{"id":"GO:0097067","count":17},{"id":"GO:0034769","count":17},{"id":"GO:0035593","count":17},{"id":"GO:0060448","count":17}]},{"hash":"273076678940477412","title":"Embryonic Morphogenesis and Development","description":"This cluster shows a broad enrichment for embryonic development and morphogenesis across multiple organs (facial/skull formation, digits, limbs, skeleton, heart outflow tract, pituitary, brain regions) and includes neuronal differentiation/commitment terms, indicating a cohesive theme of vertebrate organogenesis during embryogenesis.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":8},{"id":"GO:0042733","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0021796","count":7},{"id":"GO:0035116","count":7}]},{"hash":"43552819181558131","title":"Ubiquitination and protein degradation","description":"The top GO terms are dominated by ubiquitination processes: protein ubiquitination, ubiquitin-dependent protein catabolic process, and protein autoubiquitination, indicating the cluster centers on tagging proteins for degradation or regulation via ubiquitin. Additional terms like negative regulation of apoptosis align with ubiquitin-mediated control of cell fate, while vitamin D response and V(D)J recombination appear ancillary. Overall, the group appears ubiquitination-centric.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":12},{"id":"GO:0042787","count":12},{"id":"GO:0033280","count":11},{"id":"GO:0000209","count":10},{"id":"GO:0043066","count":10}]},{"hash":"1832768084037655671","title":"Embryonic development and organ morphogenesis","description":"This cluster is dominated by GO terms related to embryonic development, pattern formation, and morphogenesis across multiple tissues and organs (mesoderm, cartilage, hair follicles, roof of the mouth, placenta/trophoblast, endocrine system, and pancreatic development). The repeated emphasis on developmental processes and tissue morphogenesis suggests proteins function together in orchestrating embryogenesis and organ formation rather than a single specific pathway.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0007498","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060021","count":3}]},{"hash":"1746541979820811000","title":"ECM remodeling and coagulation regulation","description":"This cluster centers on collagen fibril organization, proteolysis/fibrinolysis, regulation of platelet activity and vasoconstriction, and endothelial cell survival, together pointing to extracellular matrix remodeling and vascular/coagulation/immune proteolysis pathways. A couple of terms like single fertilization and RTK activation are less directly related, but the dominant theme aligns with ECM and vascular proteolytic processes.","confidence":"Medium","size":26,"edges":26,"triangles":5,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0045907","count":4},{"id":"GO:0090331","count":4},{"id":"GO:0006508","count":3}]},{"hash":"2299736916061700144","title":"Proteoglycan biosynthesis and sulfation","description":"The top GO terms cluster around proteoglycan biosynthesis, especially heparan sulfate and chondroitin sulfate, and include protein sulfation, indicating a cohesive role in assembling and modifying glycosaminoglycans. Additional metabolic terms such as xenobiotic, catecholamine, bile acid, and thyroid hormone metabolism may reflect broader sulfation-related processing and signaling context. Overall, the cluster centers on proteoglycan biosynthesis and sulfation.","confidence":"High","size":26,"edges":265,"triangles":1567,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":22},{"id":"GO:0015015","count":22},{"id":"GO:0045600","count":18},{"id":"GO:0030210","count":18},{"id":"GO:0006805","count":18}]},{"hash":"1792279911871674977","title":"Immune cell adhesion and T cell costimulation","description":"This cluster is dominated by GO terms for cell\u2013cell adhesion (both homophilic and heterophilic) and signals that promote T cell\u2013mediated immune responses, including T cell costimulation, cytokine production (notably IL-4), and neutrophil recruitment, indicating a theme of immune cell interactions and activation; a few outliers exist but the main signal is immune adhesion and T cell activation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":22},{"id":"GO:0007157","count":22},{"id":"GO:0045404","count":21},{"id":"GO:0031295","count":21},{"id":"GO:0007286","count":21}]},{"hash":"504064883297383597","title":"Developmental organogenesis and tissue formation","description":"This cluster centers on development across various organs and tissues, including amelogenesis, myelination, pancreas morphogenesis, and digestive system development, along with post-embryonic growth and overall multicellular growth. Additional terms reflect transcription regulation and tissue remodeling during development, suggesting a unifying theme of growth and differentiation rather than a single pathway.  ","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097186","count":4},{"id":"GO:0042552","count":3},{"id":"GO:0006682","count":3},{"id":"GO:0061113","count":3},{"id":"GO:0009791","count":3}]},{"hash":"594504586955218402","title":"Embryonic development and morphogenesis","description":"The cluster is dominated by GO terms tied to embryonic development and organ morphogenesis across multiple systems (brain, digits, cranial skeleton, nephric/ureteric branching), suggesting a set of proteins involved in developmental patterning rather than a single pathway. Some broader terms like regulation of binding and behavior appear, but the central theme remains morphogenesis during embryogenesis.","confidence":"High","size":26,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051098","count":26},{"id":"GO:0044708","count":26},{"id":"GO:0021985","count":26},{"id":"GO:0090190","count":26},{"id":"GO:0007420","count":26}]},{"hash":"1662456521227296312","title":"Multi-tissue Development and Signaling","description":"This cluster is enriched for development-related GO terms across multiple tissues (heart, kidney/glomerulus, enteric nervous system, saliva glands) and includes related signaling (ERK cascade) and nervous/immune terms, suggesting a broad developmental/signaling program rather than a single tissue-specific function.","confidence":"Medium","size":26,"edges":135,"triangles":201,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042742","count":25},{"id":"GO:0070374","count":24},{"id":"GO:0007507","count":24},{"id":"GO:0030168","count":22},{"id":"GO:0046541","count":21}]},{"hash":"955379424123649601","title":"Bacterial cell wall catabolism and defense","description":"This cluster is dominated by GO terms for peptidoglycan and cell wall macromolecule catabolic processes, and the defense response to bacterium, pointing to proteins involved in breaking down bacterial cell walls and mounting antibacterial defenses. While other terms (e.g., viral release from host cell, locomotion) appear, the strongest signals relate to bacterial cell wall degradation and host defense, suggesting a coherent theme around bacterial interaction and immune response. ","confidence":"Medium","size":26,"edges":244,"triangles":1123,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":26},{"id":"GO:0019835","count":26},{"id":"GO:0019076","count":26},{"id":"GO:0009253","count":26},{"id":"GO:0007194","count":26}]},{"hash":"1992414247369370855","title":"GTPase-driven cytoskeletal regulation and apoptosis","description":"The cluster\u2019s top GO terms point to small GTPase\u2013mediated signaling that drives actin cytoskeleton remodeling and modulates cell\u2013cell adhesion, alongside regulatory inputs to apoptosis pathways (including T cell death). This suggests a theme where signaling through GTPases coordinates cytoskeletal dynamics and adhesion with immune-related apoptosis cues. The outlier term related to sensory perception of sound is likely incidental noise rather than a defining feature of the cluster.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0090630","count":4},{"id":"GO:0097194","count":4},{"id":"GO:0006924","count":3},{"id":"GO:0033633","count":3}]},{"hash":"2140721222777852481","title":"Mitochondrial vitamin and metabolite transport","description":"The top GO terms cluster around transport of cofactors and metabolites across the mitochondrial membrane (pyridoxal phosphate, thiamine pyrophosphate, iron import into mitochondrion, thiosulfate, phosphate), along with related processes like the malate-aspartate shuttle and adaptive thermogenesis. This pattern indicates a cohesive function focused on mitochondrial metabolite/cofactor transport and energy metabolism, with ancillary links to mitochondrial remodeling and thermogenic responses.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0031921","count":26},{"id":"GO:1990314","count":26},{"id":"GO:0015709","count":26},{"id":"GO:0008637","count":26},{"id":"GO:0043490","count":26}]},{"hash":"751385453592582801","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":23,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006189","count":6},{"id":"GO:0017000","count":5},{"id":"GO:0006574","count":5},{"id":"GO:0060992","count":4},{"id":"GO:0055114","count":4}]},{"hash":"266412164666835333","title":"Chromatin Assembly and Transcription Regulation","description":"The top GO terms cluster around chromatin-related processes (nucleosome assembly, DNA integration) and transcription control (positive regulation of transcription elongation by RNA Pol II), with supporting RNA processing and stability activities (mRNA stabilization, nonsense-mediated decay) and TORC1 signaling. Although there are no observed edges among proteins, the annotations collectively point to regulation of gene expression at the chromatin and RNA levels, suggesting a cohesive theme of transcriptional and chromatin regulation for this cluster.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0033138","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0055013","count":2}]},{"hash":"32978981409845471","title":"Dopaminergic neural signaling","description":"The cluster centers on nervous system signaling and development, with strong representation of dopaminergic synaptic transmission, neuropeptide signaling, and enteric nervous system development, plus related behaviors like grooming and pain perception. While a couple terms (saliva secretion, metanephric glomerulus development) are less directly neural, the dominant pattern points to dopamine-associated neural communication and development.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":26},{"id":"GO:0072224","count":26},{"id":"GO:0060160","count":26},{"id":"GO:0048484","count":26},{"id":"GO:2000458","count":26}]},{"hash":"854501135426144747","title":"Vision-associated GPCR signaling and glutamatergic transmission","description":"This cluster centers on neural signaling related to vision: GPCR signaling, PLC activation, calcium influx, and regulation of glutamatergic synaptic transmission, along with light-stimulus detection and visual perception. While electron transport chain terms are broad, the dominant pattern is GPCR-Ca2+-glutamate signaling in retinal/visual neural pathways and related electrical responsiveness and locomotor outputs.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0030818","count":25},{"id":"GO:0090280","count":25},{"id":"GO:0007206","count":25},{"id":"GO:0022900","count":25},{"id":"GO:0050908","count":25}]},{"hash":"1641788914696931260","title":"Unknown","description":"The GO terms cover immune signaling (interferon responses, biotic stimulus), vesicle trafficking (endosome to plasma membrane transport, synaptic vesicle clustering), metabolism (glucose import in response to insulin), and bone development (bone morphogenesis/mineralization), with no single unifying function to tie the cluster together; thus a specific label is not apparent.","confidence":"","size":25,"edges":70,"triangles":48,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0046597","count":4},{"id":"GO:0060349","count":4},{"id":"GO:0030282","count":4},{"id":"GO:0044381","count":4},{"id":"GO:0099638","count":4}]},{"hash":"1472335361719878736","title":"Neural development and blood-nerve barrier transport","description":"Top GO terms point to neural development (neuromuscular junction formation, postsynaptic receptor dynamics, cell-cell adhesion), ion transport, and barrier/vascular interface functions (tight junction assembly, xenobiotic transport across the blood-nerve barrier) with vasculature involvement, suggesting a cluster coordinating synapse formation with barrier and vascular interfaces.","confidence":"Medium","size":25,"edges":130,"triangles":316,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":12},{"id":"GO:0016049","count":11},{"id":"GO:0007528","count":9},{"id":"GO:0035725","count":9},{"id":"GO:0061772","count":9}]},{"hash":"1385923841365622667","title":"Meiosis and sporulation regulation","description":"The Top Terms point to meiotic processes (DSB formation, recombination, transcription regulation in meiosis, chromosome condensation) and ascospore formation, with supporting signaling via calcineurin-NFAT. Despite a few unrelated or obsolete terms (and a glycogen metabolism item), the dominant theme is meiotic division and sporulation regulation, likely in a fungal context.","confidence":"Medium","size":25,"edges":60,"triangles":18,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051533","count":5},{"id":"GO:0030437","count":5},{"id":"GO:0070940","count":5},{"id":"GO:0050774","count":5},{"id":"GO:0051037","count":4}]},{"hash":"629150256301483508","title":"ER-Golgi Trafficking and Secretion","description":"This cluster is driven by GO terms related to exit from the endoplasmic reticulum, ER-to-Golgi vesicle transport, general protein transport, and calcium-dependent exocytosis, pointing to a shared role in the secretory pathway and vesicle trafficking; the GPI anchor attachment term further supports processing of secreted/membrane proteins, with some peripheral terms indicating related signaling or cytokine aspects.","confidence":"Medium","size":25,"edges":142,"triangles":441,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0070863","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0010867","count":1},{"id":"GO:0035307","count":1},{"id":"GO:0045806","count":1}]},{"hash":"1366688112151882006","title":"Membrane Ion Transport and Development","description":"The cluster is enriched for membrane ion transport terms (chloride, potassium, calcium, glycine betaine transport), pointing to transporter/channel proteins. It also includes development-related terms (heart development, visual perception, axonogenesis, skin development), suggesting these transporters participate in developmental and tissue-specific processes. Additional terms tied to cell cycle and transcription regulation imply broader cellular roles that can intersect development and proliferation. Overall, a coherent theme of membrane transport linked to developmental functions fits best.","confidence":"Medium","size":25,"edges":41,"triangles":36,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902476","count":6},{"id":"GO:0006813","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0000278","count":6}]},{"hash":"2227546044754939445","title":"Actin cytoskeleton remodeling and mitosis regulation","description":"The top GO terms center on Arp2/3-mediated actin nucleation and cytoskeletal remodeling, along with mitotic cell cycle and cytokinesis, plus muscle development and signaling contexts. This suggests a cohesive cluster of proteins coordinating cytoskeletal dynamics with cell division, with secondary links to muscle development and signaling pathways.","confidence":"High","size":25,"edges":99,"triangles":202,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000601","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0010801","count":4},{"id":"GO:0051591","count":3}]},{"hash":"252644764212652148","title":"Mammary Gland Development and Lactation","description":"This cluster shows strong representation of mammary-associated processes (mammary gland epithelial cell proliferation, lactation) along with cell cycle and transcriptional regulation (DNA-templated transcription, G1/S transition, CDK activity), and metabolic signaling (insulin receptor signaling). The combination points to a module governing mammary gland development, proliferation, and lactation.","confidence":"Medium","size":25,"edges":268,"triangles":1712,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046626","count":16},{"id":"GO:0006351","count":16},{"id":"GO:0000320","count":15},{"id":"GO:0033598","count":15},{"id":"GO:0045737","count":15}]},{"hash":"586075285388561687","title":"Retina development and photoreceptor differentiation","description":"The majority of top GO terms point to eye/retina biology: visual perception, retina vasculature development in a camera-type eye, and photoreceptor cell differentiation, indicating proteins involved in retinal development and photoreceptor function. Additional terms about Notch signaling, integrin signaling, and cell motility fit developmental processes and cell adhesion in the retina, while melanosome/lysosome localization and endosome transport relate to pigment cell and organelle trafficking relevant to the retinal pigment epithelium. Overall, the dominant theme is retina/eye development and photoreceptor differentiation.","confidence":"High","size":25,"edges":280,"triangles":1898,"max_degree":24,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0007601","count":18},{"id":"GO:0045747","count":18},{"id":"GO:0061298","count":18},{"id":"GO:2000145","count":18},{"id":"GO:0090528","count":18}]},{"hash":"482657189745655055","title":"Arginine/Ornithine Transport and NO-Mediated Inflammation","description":"The cluster prominently features amino acid transport terms (L-arginine, L-ornithine, transepithelial ammonium transport) and nitric oxide production in inflammatory response, suggesting a coordinated membrane transport and NO signaling role in inflammation. A transcription-regulation term is present but less central to the dominant transport/metabolic theme, so the label focuses on the amino acid transport and NO/inflammatory link.","confidence":"Medium","size":25,"edges":40,"triangles":46,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":6},{"id":"GO:0098713","count":5},{"id":"GO:0070634","count":5},{"id":"GO:0002537","count":5},{"id":"GO:0097638","count":5}]},{"hash":"724441338841571041","title":"Mitotic spindle and microtubule dynamics","description":"The terms cluster around microtubule-based transport and mitotic spindle processes: nuclear migration along microtubules, centrosome separation, spindle assembly, and directed microtubule sliding, with related axonemal tubulin activities. Together these indicate a coherent theme of mitotic machinery and microtubule motor function governing chromosome movement and cell division, with some development-associated context.","confidence":"High","size":25,"edges":292,"triangles":2144,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0030473","count":24},{"id":"GO:0007100","count":24},{"id":"GO:0000743","count":24},{"id":"GO:1990942","count":24},{"id":"GO:0031535","count":24}]},{"hash":"425451747099188918","title":"Ribosome biogenesis and RNA processing","description":"The cluster centers on RNA processing and ribosome assembly, with strong signals for cytoplasmic translation, ribosomal subunit biogenesis, and rRNA maturation, plus spliceosome-mediated mRNA splicing and exon ligation, indicating a cohesive module of proteins involved in RNA maturation and ribosome assembly that underpins translation.","confidence":"High","size":25,"edges":105,"triangles":198,"max_degree":16,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":9},{"id":"GO:1903833","count":9},{"id":"GO:0051301","count":9},{"id":"GO:0000466","count":9},{"id":"GO:0000463","count":9}]},{"hash":"1193005899041172659","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The cluster is dominated by terms related to actin cytoskeleton organization, lamellipodium assembly, and cell migration, with proteins linked to Rho/Ras signaling and heart development, indicating a module focused on actin-driven motility and cytoskeletal dynamics in cardiac contexts.","confidence":"High","size":25,"edges":243,"triangles":1324,"max_degree":24,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0016477","count":15},{"id":"GO:0007205","count":15},{"id":"GO:0035023","count":14},{"id":"GO:2001275","count":13},{"id":"GO:0030036","count":13}]},{"hash":"655695862690779061","title":"Rho and Ras Signaling with Synaptic Plasticity","description":"This cluster centers on regulation of intracellular signaling, especially Rho and Ras pathways, and on synaptic processes such as long-term potentiation and synapse assembly. The presence of both GTPase signaling terms and synaptic plasticity terms suggests a core theme of regulated signal transduction linked to synaptic function, with additional immune and vascular remodeling terms reflecting broader signaling roles. ","confidence":"Medium","size":25,"edges":45,"triangles":31,"max_degree":9,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":10},{"id":"GO:0046580","count":9},{"id":"GO:0060313","count":9},{"id":"GO:0043314","count":9},{"id":"GO:0060291","count":9}]},{"hash":"2008380918493875374","title":"Mitotic and meiotic chromosome dynamics","description":"The cluster shows a strong signal for chromosome segregation and sister chromatid cohesion/separation (meiosis I, mitotic sister chromatid separation, cohesion, homologous chromosome segregation), indicating a core role in chromosome dynamics during cell division. While some terms touch on tissue morphogenesis and ribosome biogenesis, the dominant pattern is chromosome dynamics, justifying this label. ","confidence":"Medium","size":25,"edges":199,"triangles":804,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0007127","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007443","count":3},{"id":"GO:0007502","count":3},{"id":"GO:0051306","count":3}]},{"hash":"1786940649918036658","title":"Cardiac morphogenesis and ventricular electrophysiology","description":"The top GO terms cluster around heart development (outflow tract morphogenesis, left ventricular morphogenesis) and electrical properties of cardiac muscle (regulation of depolarization and ventricular action potential), with related terms on stress-induced hypertrophy and mechanosensation, suggesting a cohesive theme of cardiac formation and electrical function. ","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":18},{"id":"GO:0050976","count":18},{"id":"GO:0019233","count":18},{"id":"GO:0050966","count":18},{"id":"GO:0060371","count":18}]},{"hash":"1459437623958301732","title":"Transmembrane Transporters for Ions, Sugars, and Xenobiotics","description":"The top GO terms are dominated by diverse transmembrane transport activities (ions like sodium, various sugars such as arabinose and galactose, xenobiotics, phosphate, sialic acid, nitrate, fucose) and a neuronal process of neurotransmitter loading into synaptic vesicles, pointing to a cluster of membrane transporter proteins handling a wide range of substrates as well as related vesicular transport. ","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010875","count":6},{"id":"GO:0035725","count":6},{"id":"GO:0006855","count":6},{"id":"GO:0015751","count":6},{"id":"GO:0015739","count":6}]},{"hash":"1118614592398792962","title":"Neural development and brain formation","description":"Dominant GO terms are nervous system development, forebrain and cerebral cortex development, neural tube closure, and DNA-templated transcription, pointing to neural development and brain formation as the core function of this cluster. Some stress and immune-related terms (ER-stress apoptosis, LPS response) are present but secondary. Therefore the label captures the primary theme.","confidence":"High","size":25,"edges":87,"triangles":98,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0030900","count":11},{"id":"GO:0006351","count":11},{"id":"GO:0001843","count":11}]},{"hash":"1597722321450553797","title":"Cardiovascular development: endocardial EMT and ECM adhesion","description":"The GO terms cluster around cell-matrix adhesion, collagen organization, and endothelial/epithelial-to-mesenchymal transitions involved in endocardial cushion formation, along with morphogenesis of the dorsal aorta and responses to shear stress, all pointing to cardiovascular development driven by ECM interactions and EMT processes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0035987","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0045715","count":3},{"id":"GO:0003273","count":3}]},{"hash":"123938008127430171","title":"Ubiquitin-Dependent Proteostasis and Mitophagy","description":"The GO terms are strongly centered on ubiquitin-mediated protein degradation (autoubiquitination, ubiquitin-dependent ERAD, K48-linked ubiquitination, aggresome formation) and protein catabolism, with additional links to mitophagy and regulation of mitochondrial fusion, indicating a cohesive theme of cellular protein quality control and mitochondrial turnover through ubiquitin pathways.","confidence":"High","size":25,"edges":140,"triangles":322,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051865","count":10},{"id":"GO:0070842","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0030433","count":8},{"id":"GO:0042787","count":7}]},{"hash":"2027819384739306240","title":"Neural development and stress response network","description":"Neural terms dominate, with cerebral cortex and corpus callosum development and axon regeneration, and stress signaling (ER stress\u2013induced apoptosis, JNK regulation, anoikis) also present; while some terms relate to DNA damage checkpoints and meiosis, the shared theme is developmental programs in neural tissue coupled with stress-response signaling.","confidence":"Medium","size":25,"edges":55,"triangles":35,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":25},{"id":"GO:0070059","count":25},{"id":"GO:0046329","count":25},{"id":"GO:0072428","count":25},{"id":"GO:0021987","count":25}]},{"hash":"2099614366371345509","title":"MAPK Signaling in Development","description":"The ERK1/ERK2 cascade (MAPK signaling) is the standout term, and several other terms point to developmental processes (odontogenesis, angiogenesis, morphogenesis-associated apoptosis, differentiation of hormone-secreting cells). This suggests a cluster of proteins tied to MAPK-driven developmental signaling and morphogenesis.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070371","count":3},{"id":"GO:0042475","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0007026","count":3}]},{"hash":"1144221488004786769","title":"Organelle Energy Metabolism and Translation","description":"The cluster is enriched for mitochondrial electron transport and ATP synthesis related GO terms (NADH to ubiquinone, ubiquinol to cytochrome c, proton transmembrane transport, mitochondrial translation, tRNA processing, ribosome disassembly), indicating a role in organelle energy production. The presence of photosynthesis and light-reaction terms suggests chloroplast involvement as well, pointing to a shared theme of energy metabolism and the accompanying protein synthesis machinery in mitochondria/chloroplasts, making this label representative of the cluster\u2019s function.","confidence":"High","size":25,"edges":280,"triangles":2030,"max_degree":24,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006120","count":4},{"id":"GO:0006122","count":3},{"id":"GO:0015979","count":3},{"id":"GO:1902600","count":3}]},{"hash":"222972091800203824","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster centers on ubiquitin-related protein turnover and signaling: multiple terms point to ubiquitin-dependent proteolysis (polyubiquitination, autoubiquitination, and ERAD pathways, including K63-linked ubiquitination). It also links to downstream signaling processes like NF-kappaB activation and JNK cascade regulation, suggesting a broader role of ubiquitin tagging in proteostasis and signaling. A few terms are obsolete or peripheral (e.g., V(D)J recombination, voltage-gated channel regulation), but the dominant theme is ubiquitin-mediated protein degradation and regulation.","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0000209","count":18},{"id":"GO:0030433","count":17},{"id":"GO:0051865","count":16},{"id":"GO:0090073","count":16}]},{"hash":"2160819459877987942","title":"Blood Coagulation and Fibrinolysis Regulation","description":"Most of the top GO terms point to coagulation and fibrinolysis processes (blood coagulation; negative regulation of plasminogen activation; negative regulation of fibrinolysis; fibrinolysis), with additional terms related to angiotensin regulation and extracellular matrix secretion, suggesting a vascular-regulatory cluster coordinating coagulation and matrix remodeling. Immune signaling terms appear less dominant. ","confidence":"High","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002002","count":3},{"id":"GO:0003331","count":3},{"id":"GO:0010757","count":3},{"id":"GO:0051918","count":3},{"id":"GO:0007596","count":3}]},{"hash":"429892879244043891","title":"Neural Development and Growth Factor Signaling","description":"Most terms cluster around nervous system development, synapse assembly, and brain-specific growth factor signaling (FGF receptor, ERK/MAPK, VEGF/PDGF pathways), suggesting a cohesive theme of neural development guided by growth-factor\u2013mediated signaling. A few terms touch hematopoietic or cardiovascular development, likely reflecting shared signaling components but not overriding the neural emphasis.","confidence":"High","size":25,"edges":9,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007399","count":14},{"id":"GO:0070374","count":12},{"id":"GO:0051965","count":12},{"id":"GO:0007507","count":12},{"id":"GO:0035607","count":11}]},{"hash":"2149459678194426217","title":"T cell Regulation and Innate Immunity","description":"The cluster is dominated by GO terms tied to immune function, including negative regulation of activated T cell proliferation, defense against bacteria, and both innate and adaptive immune responses, plus type II interferon production, T cell costimulation, IL-4 production, and cell\u2013cell adhesion. This points to a cohesive theme of immune signaling and control of T cell activity across innate and adaptive arms, with adhesion facilitating immune interactions. The spermatid development term appears as an outlier rather than the defining feature. Confidence: High","confidence":"","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046007","count":13},{"id":"GO:0042742","count":13},{"id":"GO:0045087","count":12},{"id":"GO:0002250","count":11},{"id":"GO:0072643","count":11}]},{"hash":"945474516704994677","title":"Unknown","description":"The top GO terms span multiple, seemingly unrelated biological areas (translation and mitochondrial protein import pointing to protein biogenesis; but also bacterial-specific processes like lipid A biosynthesis, cell wall organization, and antibiotic biosynthetic processes, plus broad stress responses), with no clear, cohesive functional theme tying the cluster together. This makes it difficult to assign a concise, representative function label, so \"Unknown\" is appropriate.","confidence":"","size":25,"edges":232,"triangles":1170,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0030150","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006457","count":2},{"id":"GO:0050790","count":2}]},{"hash":"825175537880957787","title":"Developmental morphogenesis and cell adhesion","description":"The GO terms point to tissue development and morphogenesis, including skeletal system morphogenesis, bone mineralization, and nervous system development, along with actin filament bundle organization, cell-cell adhesion, and cell-cell signaling. EMT also reflects morphogenetic transitions. A couple terms (mitochondrial ribosome assembly, lipid tube assembly) appear ancillary but do not override the central developmental theme. Overall, the cluster appears to represent developmental morphogenesis and intercellular communication.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061572","count":1},{"id":"GO:0001837","count":1},{"id":"GO:0061182","count":1},{"id":"GO:0048705","count":1},{"id":"GO:1900158","count":1}]},{"hash":"1230337767619678943","title":"Mitotic control and signaling pathways","description":"This cluster shows strong enrichment for cell cycle and mitosis-related terms (exit from mitosis, mitotic cytokinesis checkpoint signaling, mitotic sister chromatid biorientation) along with key signaling pathways (Notch signaling, ERK cascade, JAK-STAT modulation). The presence of circadian rhythm and osmotic stress response suggests broader regulatory signaling connections, but the dominant theme centers on cell cycle control and signaling networks.","confidence":"Medium","size":25,"edges":148,"triangles":443,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0035335","count":19},{"id":"GO:0031536","count":16},{"id":"GO:0039563","count":16},{"id":"GO:0071850","count":16},{"id":"GO:0070373","count":16}]},{"hash":"1198195106853713528","title":"Integrin signaling and actin cytoskeleton remodeling","description":"This cluster is dominated by GO terms tied to integrin activation and its regulation, along with processes driving cytoskeletal dynamics such as filopodium assembly, Rho signaling, and cell migration. The convergence on adhesion receptors and actin remodeling suggests a coherent theme of integrin-mediated adhesion and motility machinery.","confidence":"High","size":25,"edges":112,"triangles":166,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0033622","count":4},{"id":"GO:0051262","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1105410477820728920","title":"Embryogenesis and Organogenesis","description":"This cluster's top GO terms indicate developmental processes, with emphasis on left-right pattern formation, endocrine system development, heart-related EMT in the endocardial cushion, cartilage morphogenesis, placenta-associated differentiation, and pancreatic cell development. The consistent theme is embryonic tissue patterning and organ formation rather than mature cellular functions.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0060972","count":19},{"id":"GO:0035270","count":19},{"id":"GO:0003198","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0060536","count":19}]},{"hash":"1089874098207611854","title":"Embryonic Development and Tissue Differentiation","description":"The top GO terms point to a broad set of developmental and differentiation processes across multiple tissues\u2014left/right patterning, endocrine system development, EMT in heart and endocardial cushion, placenta-related differentiation, cartilage morphogenesis, trophoblast and pancreatic cell development, B cell signaling, skeletal muscle development, and innate immunity\u2014indicating a theme of embryonic organogenesis and lineage specification rather than a single pathway.","confidence":"High","size":25,"edges":3,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060536","count":6}]},{"hash":"1518784184187732787","title":"Adaptive immune activation and signaling","description":"Many top terms point to immune defense and activation (defense response to bacterium, classical complement activation, T cell costimulation, IL-4 production) and key signaling pathways (STAT tyrosine phosphorylation, ERK cascade). While a couple terms like melanocyte differentiation and heart development appear, the dominant theme is adaptive immune signaling. Therefore the label Adaptive immune activation and signaling is representative of this cluster.","confidence":"High","size":25,"edges":35,"triangles":13,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":5},{"id":"GO:0006958","count":5},{"id":"GO:0032689","count":4},{"id":"GO:0042511","count":4},{"id":"GO:0042517","count":4}]},{"hash":"1368589326174857846","title":"Neural signaling and behavior","description":"Based on the Top Terms, the cluster is enriched for neural communication genes: neuropeptide signaling, dopaminergic synaptic transmission, dopamine receptor signaling regulation, sensory perception of pain, grooming behavior, and enteric nervous system development. While there are a few outliers (saliva secretion, metanephric glomerulus development, DN2 thymocyte differentiation), the dominant theme ties to neurotransmission and neural/behavioral processes, suggesting a cluster of proteins involved in neural signaling and behavioral regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":25},{"id":"GO:0072224","count":25},{"id":"GO:0060160","count":25},{"id":"GO:0048484","count":25},{"id":"GO:2000458","count":25}]},{"hash":"38940148585752749","title":"Embryonic patterning and morphogenesis","description":"The Top Terms center on developmental processes across multiple tissues and organs\u2014left-right pattern formation, endocardial cushion EMT, cartilage morphogenesis, placental and pancreatic development, and endocrine system development\u2014suggesting a shared theme of embryonic patterning and organogenesis. A minor lipid biosynthesis term is present but does not override the overall developmental signal.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060806","count":3}]},{"hash":"882864110947531690","title":"Unknown","description":"The top GO terms show a wide mix of functions, including translation fidelity regulation, amino acid catabolism, various ion/membrane transports, immune cell proliferation, pH response, retina development, and metabolism. There isn\u2019t a single coherent biological theme tying most terms together, so a concise, representative label cannot be defined. ","confidence":"","size":25,"edges":6,"triangles":1,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006450","count":8},{"id":"GO:0006530","count":8},{"id":"GO:1902476","count":4},{"id":"GO:0006183","count":3},{"id":"GO:0046651","count":3}]},{"hash":"899054689702435034","title":"Neuroimmune MAPK Signaling and Development","description":"The set is enriched for MAPK pathway regulation (ERK/JNK cascades) and innate immune responses (LPS-related), alongside transcriptional activity and neural development terms (forebrain, nervous system). This pattern points to proteins that participate in MAPK-mediated signaling linking immune responses with neurodevelopmental processes, with ER stress\u2013related apoptosis as a stress-responsive facet.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0070059","count":3},{"id":"GO:0046641","count":3}]},{"hash":"1104477323193259155","title":"Neural development and synaptic function","description":"This cluster centers on nervous system development, neuron projection development, and synaptic components (transmission of nerve impulse, presynaptic membrane organization), indicating a cohesive neural-development/synaptic function theme. A few outlier terms exist (iron homeostasis, spermatid development, antibiotic response, sarcomere organization) but are less represented and do not disrupt the neural focus.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001736","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0055072","count":2},{"id":"GO:0007286","count":2}]},{"hash":"1190512614384187734","title":"Embryonic patterning and organogenesis","description":"The top GO terms indicate broad developmental processes such as left/right pattern formation, various organ and tissue developments (endocrine system, cartilage, heart-related EMT, placenta, pancreas), and general regulation of DNA replication/splicing\u2014collectively pointing to embryogenesis and organogenesis rather than a single pathway. This justifies a label focused on embryonic patterning and organ development rather than a narrow function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060806","count":6}]},{"hash":"933387007832454932","title":"Steroid hormone and bile acid biosynthesis","description":"The cluster is marked by annotated steroid biosynthesis and metabolism (testosterone biosynthetic process, androgen metabolic process, ecdysone biosynthetic process, aldosterone biosynthetic process) and related P450 activity (omega-hydroxylase P450 pathway), plus bile acid biosynthesis, with methylation as a broad modification term. While some developmental terms appear, the dominant signal ties to production and modification of steroid hormones and bile acids, indicating a coherent functional theme for these proteins.","confidence":"High","size":25,"edges":51,"triangles":75,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0032259","count":25},{"id":"GO:0061370","count":25},{"id":"GO:0008209","count":25},{"id":"GO:0006697","count":24},{"id":"GO:0097267","count":24}]},{"hash":"1965959312761221966","title":"Pol III transcription and translation regulation","description":"The set is enriched for translation and RNA processing terms, especially RNA polymerase III\u2013driven transcription (tRNA transcription, initiation/regulation at Pol III promoters) and SSU-rRNA maturation, pointing to a module coordinating Pol III transcription with translation/ribosome biogenesis. Some non-central terms (interferon-beta production, blastocyst formation) may reflect broader roles or incidental associations. ","confidence":"High","size":25,"edges":165,"triangles":571,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0042797","count":2},{"id":"GO:0006359","count":2},{"id":"GO:0006384","count":2}]},{"hash":"276525669942714076","title":"Embryogenesis and tissue morphogenesis","description":"The top GO terms are dominated by embryonic development and tissue formation: left/right pattern formation, endocrine system development, epithelial-to-mesenchymal transition in heart cushion formation, placenta development, cartilage morphogenesis, trophoblast differentiation, and pancreatic cell development. A few terms reference general gene expression processes (spliceosome splicing, ribosomal subunit export), but the shared theme across the cluster is developmental patterning and morphogenesis across multiple tissues. This suggests proteins involved in embryogenesis and organogenesis rather than a single specific pathway.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0060536","count":8}]},{"hash":"2193728472109198805","title":"Immune Activation and T Cell Regulation","description":"The GO terms cluster around cytokine production, T cell costimulation and regulation, and neutrophil trafficking, pointing to an immune response and leukocyte signaling. Some outliers (spermatid development, cardiac depolarization) may be incidental, but the dominant theme is immune system engagement and host interaction.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":11},{"id":"GO:0051963","count":11},{"id":"GO:0045404","count":10},{"id":"GO:0031295","count":10},{"id":"GO:0007286","count":10}]},{"hash":"2025720578393901556","title":"Unknown","description":"The top GO terms span energy production (electron transport chain) and a mix of host-pathogen processes (defense against bacteria, viral release, cytolysis) along with signaling and bacterial cell wall catabolism. There is no clear, cohesive function linking all terms to a single biological role for this cluster, making a precise label uncertain.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":12},{"id":"GO:0010579","count":10},{"id":"GO:0051930","count":10},{"id":"GO:0019835","count":10},{"id":"GO:0019076","count":10}]},{"hash":"1526874188830311571","title":"Taste Perception Cluster","description":"The top GO terms are dominated by sensory perception of taste and bitter taste detection (13 hits each), indicating a gustatory function as the main theme. While other terms appear (electron transport chain, cytolysis, defense responses), they are less represented and do not define the cluster. Thus, labeling it as Taste Perception Cluster best captures the core enrichment. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001580","count":13},{"id":"GO:0050909","count":13},{"id":"GO:0022900","count":10},{"id":"GO:0007626","count":7},{"id":"GO:0051930","count":7}]},{"hash":"516255521916217733","title":"Dopaminergic signaling and neuropeptide pathways","description":"The cluster centers on neural signaling and development, highlighted by terms like dopaminergic synaptic transmission, neuropeptide signaling, grooming behavior, sensory perception of pain, and enteric nervous system development. These suggest coordination of dopamine and peptide-based communication across neural circuits and associated behaviors. Outliers such as saliva secretion and kidney development may reflect broader regulatory roles or annotation overlap, but the dominant theme remains neural signaling and behavior.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":24},{"id":"GO:0072224","count":24},{"id":"GO:0060160","count":24},{"id":"GO:0048484","count":24},{"id":"GO:2000458","count":24}]},{"hash":"505631247830784414","title":"Neural signaling and nervous system development","description":"This cluster's GO terms are dominated by neural-related processes: neuropeptide signaling, sensory perception of pain, enteric nervous system development, grooming behavior, astrocyte chemotaxis, dopamine receptor signaling regulation, and ERK cascade modulation, pointing to a theme of neural communication and nervous system development. Some terms (saliva secretion, DN2 thymocyte differentiation) are peripheral or reflect annotation breadth, but do not override the central neural theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":25},{"id":"GO:0046541","count":24},{"id":"GO:0072224","count":24},{"id":"GO:0060160","count":24},{"id":"GO:0048484","count":24}]},{"hash":"1914695178904678320","title":"Sphingolipid and glycerophospholipid metabolism","description":"Based on the GO terms, the cluster is dominated by lipid-related processes: sphingosine/sphinganine-1-phosphate metabolic pathways, glycerophospholipid biosynthesis (phosphatidylglycerol) and phospholipid dephosphorylation, plus sphingolipid signaling. Although there are a few outlier terms (e.g., germ cell repulsion, endothelial migration, oxidant detoxification, glucose-6-phosphate transport), the overarching theme is lipid metabolism and lipid-mediated signaling, indicating a lipid-centric functional module.","confidence":"Medium","size":24,"edges":265,"triangles":1798,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006655","count":5},{"id":"GO:0035233","count":5},{"id":"GO:0044329","count":5},{"id":"GO:1902068","count":5},{"id":"GO:0006670","count":5}]},{"hash":"1720713921085030684","title":"Eye development and photoreceptor maintenance","description":"The top GO terms cluster around the visual system and photoreceptor biology\u2014photoreceptor cell maintenance, lens development, visual perception\u2014indicating a role in eye development and photoreceptor upkeep. Additional terms on apoptotic signaling and regulation of autophagy point to mechanisms governing photoreceptor survival under stress. Some terms (fungal-type cell wall organization, GPI anchor biosynthesis) are less directly related but may reflect broader cellular processes or annotation noise. Overall, the dominant theme is photoreceptor and eye development/maintenance.","confidence":"High","size":24,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042771","count":2},{"id":"GO:0045494","count":2},{"id":"GO:0031505","count":2},{"id":"GO:1902230","count":2},{"id":"GO:0007601","count":2}]},{"hash":"264632878953451592","title":"Cardiac Development and Morphogenesis","description":"The cluster is dominated by heart development and outflow tract morphogenesis terms, indicating a cardiac development program. Supporting terms about DNA-templated transcription and transcriptional regulation by RNA polymerase II point to coordinated gene regulation during development, with additional proliferation and apoptosis signals consistent with cardiac tissue formation. These together suggest a cohesive cardiac development and morphogenesis theme rather than unrelated processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1737273229181874989","title":"Membrane Transport and Development","description":"The most represented terms center on ion transport across membranes (calcium and chloride) and developmental processes (ossification, skin, vascular remodeling), suggesting proteins that couple membrane transport to tissue development. While there are some outliers (taste perception, LDL signaling), the dominant theme is membrane transport integrated with development, so this label fits best.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0098911","count":3},{"id":"GO:1902476","count":3},{"id":"GO:0032060","count":3},{"id":"GO:2000353","count":3}]},{"hash":"1858073564878612565","title":"GPCR-cAMP signaling","description":"This cluster centers on cAMP-mediated signaling initiated by GPCRs. Several top GO terms explicitly describe adenylate cyclase activation and receptor signaling pathways that stimulate cAMP production, including adrenergic and dopamine receptor signaling. This aligns with the memory and olfactory learning terms, which in many systems depend on cAMP/PKA signaling in neurons. Some yeast-specific terms (prospore membrane formation) and insulin/trehalose-related responses appear as additional roles of cAMP in stress responses, but the dominant pattern across the proteins is GPCR-triggered cAMP signaling.","confidence":"High","size":24,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007616","count":3},{"id":"GO:0008355","count":3},{"id":"GO:0007190","count":3},{"id":"GO:0035774","count":2},{"id":"GO:0032120","count":2}]},{"hash":"409924047151919173","title":"Neuronal Secretory Vesicle Maturation and Synaptic Regulation","description":"This cluster is dominated by terms related to neurosecretory and synaptic processes: dense core granule maturation, regulation of neurotransmitter secretion, and dendritic spine maintenance, plus long-term synaptic depression. The inclusion of actin cytoskeleton regulation (Arp2/3) aligns with vesicle trafficking and spine remodeling that underpin synaptic function. Although there are metabolic terms like regulation of fatty acid oxidation and insulin secretion, the strongest signals point to neuronal secretion and synaptic regulation as the core theme. Therefore, the proposed label captures the central function represented by these proteins.","confidence":"High","size":24,"edges":73,"triangles":122,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0032000","count":4},{"id":"GO:0031999","count":4},{"id":"GO:0050796","count":3}]},{"hash":"1768239385274597390","title":"Neuroendocrine Stress Response and Dopaminergic Signaling","description":"The cluster is enriched for terms tied to stress hormone regulation (cortisol/corticosterone secretion), stress responses, nervous system development, and dopaminergic synaptic transmission, suggesting a cohesive theme of neuroendocrine stress signaling and dopamine-mediated neural communication, with supporting links to locomotor rhythms and related processes.","confidence":"High","size":24,"edges":57,"triangles":62,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0051464","count":3},{"id":"GO:0035902","count":3},{"id":"GO:0006517","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0031175","count":2}]},{"hash":"2268832981737503208","title":"Golgi\u2013endosome\u2013lysosome trafficking with PI signaling","description":"This cluster is dominated by terms describing intracellular transport within the secretory pathway, including endosome-to-lysosome transport, Golgi retention, intralumenal vesicle formation, and PI-mediated signaling. Although mitotic and developmental terms appear, the strongest and most coherent signal centers on vesicle trafficking and Golgi/lysosome dynamics, justifying a label focused on this shared function.","confidence":"Medium","size":24,"edges":215,"triangles":1118,"max_degree":22,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048015","count":4},{"id":"GO:0006886","count":4},{"id":"GO:0008333","count":4},{"id":"GO:0045053","count":4},{"id":"GO:0070676","count":4}]},{"hash":"1848172819805326502","title":"Immune Signaling and Cytoskeletal Dynamics","description":"The cluster centers on signaling pathways mediated by small GTPases (Ras/Rho) and receptor signaling (ephrin, insulin), and includes immune-related processes (B cell affinity maturation, NK T cell differentiation, IL-7 response) together with lamellipodium assembly, indicating a theme of immune signaling coupled with cytoskeletal remodeling and cell migration. While there are some broader developmental signals (heart development, insulin signaling) these do not override the dominant pattern of immune signaling and actin dynamics.","confidence":"Medium","size":24,"edges":227,"triangles":1215,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046580","count":23},{"id":"GO:0035023","count":23},{"id":"GO:0048013","count":22},{"id":"GO:0008286","count":22},{"id":"GO:0007507","count":22}]},{"hash":"1302161498802638799","title":"Lamellipodium formation and cell migration via Rho signaling","description":"The cluster is strongly enriched for lamellipodium assembly and regulation of Rho signaling, both core to actin cytoskeleton remodeling and cell movement. While there are additional terms spanning development and immune signaling, the dominant theme centers on actin-driven motility and migratory capacity, with Rho pathways as a key regulatory hub. This makes the label a concise, representative description of the cluster\u2019s core function.","confidence":"High","size":24,"edges":18,"triangles":4,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030032","count":13},{"id":"GO:0035023","count":11},{"id":"GO:0008286","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0098761","count":11}]},{"hash":"1419351123628091932","title":"Developmental transcription regulation and spindle assembly","description":"Most GO terms emphasize transcriptional control (regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II) and mitotic/spindle processes (spindle assembly), with additional lineage- and development-related terms (germline, follicle cell stalk formation, embryonic skeletal development). This suggests a cluster of proteins coordinating gene expression during development and cell division, including organism-specific developmental roles.","confidence":"High","size":24,"edges":258,"triangles":1781,"max_degree":23,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":9},{"id":"GO:0051225","count":8},{"id":"GO:0030851","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0030713","count":6}]},{"hash":"449959928776367072","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":256,"triangles":1630,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":11},{"id":"GO:0000463","count":11},{"id":"GO:0000466","count":10},{"id":"GO:0051301","count":8},{"id":"GO:0042273","count":8}]},{"hash":"2065955501599147082","title":"DNA Damage Response and Transcription Regulation","description":"The cluster shows enrichment for transcription regulation and DNA repair processes, notably transcription-coupled and pyrimidine dimer repair by nucleotide-excision repair, plus UV-B response and cell cycle regulation, indicating a functional module linking transcription control to DNA damage response and repair. A few GO terms related to insulin signaling are present but less central.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0040034","count":1},{"id":"GO:0006283","count":1},{"id":"GO:0045944","count":1}]},{"hash":"62509105094771978","title":"Muscle development and transcriptional regulation","description":"The terms point to transcriptional regulation and muscle formation: regulation of DNA-templated transcription, estrogen receptor signaling, and myoblast differentiation/myotome development. Ubiquitin-related deubiquitination also appears, aligning with protein-regulation during development. A few terms (endothelial proliferation, thigmotaxis) are less specific but reflect broader developmental signaling contexts, reinforcing a muscle-development focus rather than a single pathway.","confidence":"Medium","size":24,"edges":28,"triangles":9,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0001935","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0030520","count":2},{"id":"GO:0001966","count":2}]},{"hash":"434444488530488504","title":"Apoptosis, epithelial differentiation, and gene regulation","description":"The cluster includes apoptotic processes (myeloid and hepatocyte), epithelial cell polarity and maturation, and foundational cellular regulation such as protein ubiquitination, transcription, and mRNA processing, suggesting a set of proteins involved in cell fate decisions and turnover with epithelial development context rather than a single pathway.","confidence":"Medium","size":24,"edges":16,"triangles":1,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033028","count":4},{"id":"GO:0097284","count":4},{"id":"GO:2000171","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0071260","count":4}]},{"hash":"2260534670938847473","title":"NF-kappaB\u2013mediated immune signaling","description":"The top terms center on NF-kappaB transcription and signaling, with several terms linked to immune responses (LPS, muramyl dipeptide, B cell signaling, spleen development). This suggests the cluster comprises proteins involved in NF-kappaB\u2013driven immune activation. A couple of peripheral terms (growth factor response, microtubule localization) are minor noise.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":9},{"id":"GO:0043123","count":7},{"id":"GO:0032495","count":6},{"id":"GO:0048536","count":6},{"id":"GO:0035729","count":5}]},{"hash":"262602495684434241","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":8,"triangles":2,"max_degree":4,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":18},{"id":"GO:1901253","count":18},{"id":"GO:1903762","count":18},{"id":"GO:0061158","count":18},{"id":"GO:0033209","count":17}]},{"hash":"1310833119771743711","title":"Embryonic Eye Morphogenesis and Organogenesis","description":"Based on GO terms, the cluster is strongly enriched for eye development (camera-type eye development, embryonic eye morphogenesis) and broader embryonic organogenesis (heart tube development, lung morphogenesis, pancreas development, somitogenesis), with accompanying transcriptional regulation. This pattern suggests a group of proteins involved in early ocular development and related organ formation.","confidence":"High","size":24,"edges":30,"triangles":16,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0043010","count":10},{"id":"GO:0048048","count":10},{"id":"GO:0060441","count":10},{"id":"GO:0000122","count":8}]},{"hash":"2126737288796412366","title":"Complement and Coagulation in Inflammation","description":"The proteins show strong enrichment for innate immune and coagulation processes (complement activation via classical and lectin pathways, regulation of membrane attack complex, leukocyte migration, blood coagulation) coupled with extracellular matrix remodeling (integrin-mediated adhesion, collagen fibril organization) and angiogenesis, suggesting a module linking inflammation with tissue remodeling and matrix dynamics rather than a single pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":10},{"id":"GO:0001970","count":8},{"id":"GO:0002523","count":8},{"id":"GO:0001867","count":7},{"id":"GO:0033631","count":7}]},{"hash":"528708066753275391","title":"Neuronal development and synaptic signaling","description":"This cluster shows strong enrichment for neural development (axonogenesis, Schwann cell development, visual perception) and synaptic plasticity (long-term potentiation, excitatory postsynaptic potential), indicating a core theme of neural development and synaptic function; other terms like heart development or cell cycle readouts are less central.","confidence":"High","size":24,"edges":132,"triangles":495,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010800","count":24},{"id":"GO:0014044","count":24},{"id":"GO:0007507","count":24},{"id":"GO:0007601","count":24},{"id":"GO:0000278","count":24}]},{"hash":"1793150611540345020","title":"Unknown","description":"The top GO terms cover a wide range of unrelated processes (growth, mechanical stimulation and pain sensing, stress responses like heat, RNA processing, immune defense, adipocyte differentiation, pinocytosis regulation, and synapse assembly), with no single unifying function tying them together. Therefore there is no coherent cluster label to assign with confidence.","confidence":"","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0051607","count":2},{"id":"GO:0045444","count":2}]},{"hash":"1934637497313591519","title":"Mitochondrial translation and respiratory chain assembly","description":"The cluster shows strong enrichment for mitochondrial translation (GO:0032543, GO:0006412), translation termination, and ribosomal subunit/mitochondrial assembly (GO:0000027, GO:0070126, GO:0034553), plus NADH-to-ubiquinone electron transport (GO:0006120). These together point to a coordinated set of proteins involved in mitochondrial gene expression and assembly of the respiratory chain complexes, particularly complex II, rather than general cytosolic translation. Hence the label focuses on mitochondrial protein synthesis and respiratory chain assembly.","confidence":"High","size":24,"edges":262,"triangles":1744,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006120","count":4},{"id":"GO:0034553","count":3},{"id":"GO:0070126","count":3},{"id":"GO:0034605","count":3}]},{"hash":"1702771815017591084","title":"Endosomal Trafficking and Autophagy Regulation","description":"Based on the top GO terms, the cluster centers on vesicle trafficking involving endosomes and lysosomes (plus-end directed transport along microtubules, endosome-to-Golgi transport, plasma membrane to endosome transport) and autophagy regulation (positive regulation of autophagosome maturation). The repeated Rab/Rap signaling terms reinforce a vesicular trafficking and membrane-dynamics theme, with phosphatidylinositol phosphate biosynthesis supporting membrane trafficking. The DNA transposition term is likely incidental. Thus the label reflects the dominant function of the cluster. ","confidence":"High","size":24,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046854","count":4},{"id":"GO:0032483","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0072383","count":2},{"id":"GO:0032418","count":2}]},{"hash":"450672034291060636","title":"Mitochondrial respiration and protein import","description":"These proteins show a strong bias toward mitochondrial-related processes: assembly of the respiratory chain complex IV, import of proteins into the mitochondrial matrix, and cellular oxidant detoxification. While a few terms are obsolete or less directly connected (aging, histone deacetylation, cortex development, fungicide response), the dominant signals point to mitochondrial energy metabolism and protein handling. This suggests a cohesive cluster of mitochondrial assembly and metabolic functions.","confidence":"High","size":24,"edges":58,"triangles":30,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0033617","count":3},{"id":"GO:0030150","count":2},{"id":"GO:0010259","count":2},{"id":"GO:0098869","count":2}]},{"hash":"409664536190446912","title":"Neural transcription and ubiquitin-mediated proteostasis","description":"The terms converge on nuclear gene expression processes (DNA-templated transcription, mRNA processing) and ubiquitin-related regulation (various deubiquitinases, ubiquitin recycling, ERAD-associated proteostasis), combined with neural development and ethanol-related behavioral terms (CNS morphogenesis, behavioral response to ethanol). This suggests a cluster of proteins involved in transcriptional control and proteostasis in neural contexts, rather than direct physical interaction. ","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006397","count":3},{"id":"GO:1990108","count":3},{"id":"GO:0044313","count":3},{"id":"GO:0010992","count":3}]},{"hash":"1909660771450523871","title":"Embryonic development and pattern formation","description":"The cluster\u2019s GO terms cluster around developmental processes: left/right pattern formation, placental and heart-related differentiation (trophoblast giant cell differentiation, EMT in endocardial cushion formation, placental development), and transcriptional regulation during embryogenesis. Despite some obsolete terms, the common theme is developmental gene regulation and differentiation programs during embryonic development.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007576","count":2},{"id":"GO:0010729","count":2},{"id":"GO:0035270","count":2}]},{"hash":"219977213760680535","title":"Coagulation, Fibrinolysis, and Angiogenesis","description":"The top GO terms show strong signals for blood coagulation and fibrinolysis (including plasminogen activation) and for regulation of these processes, with additional terms for angiogenesis and related developmental tissue remodeling (embryo implantation, smooth muscle migration, cartilage condensation). This suggests a cohesive module centered on proteolytic remodeling of vasculature and extracellular matrix during development or repair, balancing coagulation with fibrinolysis while promoting vessel formation.","confidence":"High","size":24,"edges":219,"triangles":1129,"max_degree":23,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007596","count":12},{"id":"GO:0051918","count":11},{"id":"GO:0042730","count":11},{"id":"GO:0007566","count":11},{"id":"GO:0014909","count":11}]},{"hash":"1481144714003137512","title":"Cell adhesion and neural signaling with immune regulation","description":"This cluster centers on cell-cell adhesion and neural communication (homophilic/heterophilic adhesion, transmission of nerve impulses, regulation of synapse assembly) and includes immune-modulatory terms (negative regulation of cytotoxic T cell degranulation, NK cell cytotoxicity, and macrophage activation). The presence of host-cell entry terms also suggests broader intercellular interactions at tissue interfaces. Overall, the terms point to a cohesive theme of intercellular communication across neural, immune, and tissue contexts.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":11},{"id":"GO:0086072","count":11},{"id":"GO:0043318","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0002859","count":11}]},{"hash":"53631230068781764","title":"Embryogenesis and Morphogenesis","description":"The top GO terms cluster around embryonic development and tissue formation (left/right patterning, placenta and pancreatic cell development, cartilage morphogenesis, EMT in heart development, and roof-of-mouth formation), indicating a shared role in developmental patterning and organogenesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060536","count":6}]},{"hash":"1723682261953709898","title":"Unknown","description":"The terms split between RNA splicing (spliceosomal components) and several virus-related processes (symbiont entry, proviral latency, virion assembly, viral release), with only weak overlap and some generic metabolic GO terms; there isn\u2019t a single cohesive function unifying all members, so a simple descriptive label is not justifiable.","confidence":"","size":24,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0019068","count":2},{"id":"GO:1901407","count":2}]},{"hash":"734790377686950842","title":"Calcium Signaling and Metal Ion Transport","description":"The cluster is dominated by calcium-related transport and broader metal ion homeostasis/transport (Zn, Cd, Mn), including mitochondrial calcium transport and calcium import across membranes, plus symbols of cell communication. The presence of long-term synaptic depression and regulation of heart contraction aligns with calcium-dependent signaling pathways, suggesting a cohesive theme around calcium signaling intertwined with metal ion transport.","confidence":"High","size":24,"edges":56,"triangles":57,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":8},{"id":"GO:0006882","count":8},{"id":"GO:0070574","count":8},{"id":"GO:0006851","count":7},{"id":"GO:0007154","count":7}]},{"hash":"2240646951168338283","title":"Neural development and synapse formation","description":"Top GO terms point to nervous system development, synapse assembly, neuronal adhesion, and myelination, with specific hints of auditory system development (auditory receptor cells, sensory perception of sound, corpus callosum). This suggests a coherent theme of neural development and synapse formation, including connectivity and maturation in the nervous system. ","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0042552","count":6},{"id":"GO:0007156","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0022038","count":4}]},{"hash":"2098512387733810275","title":"Mechanosensing and Gene Expression","description":"This set centers on mechanosensing (response and detection of mechanical stimulus) and RNA processing, with hints of nuclear growth regulation (telomere localization). The recurring themes are mechanical cue response and transcriptional/RNA processing activities, suggesting a nucleus-associated mechanotransduction/gene expression module, though some obsolete terms reduce coherence.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070198","count":4},{"id":"GO:0016049","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0007205","count":4}]},{"hash":"702392475807693838","title":"Innate Immune and Neuronal Remodeling","description":"The dominant GO terms cluster around innate immune response, TLR4 signaling, inflammatory regulation, and wound healing, with additional signals for axonogenesis, calcium channel regulation, and apoptosis. This suggests a group of proteins that connects immune signaling to neuronal growth/remodeling and programmed cell death, possibly reflecting neuro-immune crosstalk during repair or development. The note of spliceosome regulation hints at broader post-transcriptional control coordinating these processes.","confidence":"High","size":24,"edges":52,"triangles":64,"max_degree":15,"top_function":"wound healing","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0042060","count":5},{"id":"GO:0050729","count":5},{"id":"GO:0007409","count":5},{"id":"GO:2001244","count":5}]},{"hash":"110635933525907957","title":"Neuroimmune signaling proteins","description":"The top GO terms mix neural-related functions (brain development; regulation of dopamine secretion) with immune functions (positive regulation of B cell receptor signaling; follicular B cell differentiation), plus cellular stress regulators (apoptotic regulation; ribophagy). This suggests a cluster of proteins involved in broader neuroimmune signaling and development rather than a single, narrowly defined pathway. However, the absence of strong connectivity among members makes the link tentative, supporting a moderate level of confidence in labeling a neuroimmune signaling cluster.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":2},{"id":"GO:0071236","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0034517","count":2}]},{"hash":"662606681137232161","title":"Transmembrane solute transporters","description":"This cluster is dominated by GO terms for transmembrane transport of a wide range of solutes (sodium ions, xenobiotics, various sugars and metabolites, and even neurotransmitter loading into synaptic vesicles). The diversity of substrates still centers on the shared function of transporting solutes across membranes, suggesting a group of transporter proteins (including vesicular transporters). Therefore, labeling it as transmembrane solute transporters is a concise, representative description.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0035725","count":11},{"id":"GO:0006855","count":11},{"id":"GO:0006004","count":11},{"id":"GO:0015751","count":11},{"id":"GO:0015739","count":11}]},{"hash":"59078061517792069","title":"Embryogenesis and Endocrine Development","description":"The top GO terms cluster around embryonic patterning (left/right pattern formation) and development of endocrine lineages (endocrine system development, pancreatic beta cell development), including placental and trophoblast differentiation, endocardial cushion EMT, and cartilage morphogenesis, which collectively point to early developmental processes and lineage specification toward endocrine tissues. While some general cellular processes (mRNA splicing, ribosomal export) appear, the dominant signal is developmental patterning and differentiation. Confidence: High","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":12},{"id":"GO:0003323","count":12},{"id":"GO:0035270","count":12},{"id":"GO:0003198","count":12},{"id":"GO:0060806","count":12}]},{"hash":"1085356092703991552","title":"B cell activation and innate immunity","description":"This cluster centers on immune signaling: strong representation of B cell\u2013related terms (positive regulation of B cell activation, B cell receptor signaling, T cell costimulation) and effector/innate responses (complement activation, phagocytosis, innate immune response, neutrophil extravasation). The mix suggests a module of adaptive and innate immune activation, with a minor outlier term (white fat cell proliferation) likely reflecting incidental annotation.","confidence":"High","size":24,"edges":54,"triangles":29,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050871","count":22},{"id":"GO:0006958","count":22},{"id":"GO:0050853","count":22},{"id":"GO:0006910","count":22},{"id":"GO:0045087","count":22}]},{"hash":"1970381160023136731","title":"Neural development and sensory behavior","description":"This cluster is dominated by GO terms related to nervous system development (enteric nervous system development, neural-related development), sensory perception (visual, pain), and behavior (locomotory and grooming), plus regulation of dopamine signaling and astrocyte chemotaxis. While a couple of terms (saliva secretion, defense response to bacterium) are less connected, the overall theme centers on neural development and neural/behavioral functions, suggesting these proteins co-cluster around nervous-system\u2013driven processes.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":15},{"id":"GO:0042742","count":14},{"id":"GO:0046541","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0072224","count":12}]},{"hash":"609820846885010022","title":"Dopaminergic Neurotransmission and Nervous System Development","description":"The cluster\u2019s top GO terms are dominated by nervous system functions and dopaminergic signaling (e.g., synaptic transmission dopaminergic, regulation of dopamine receptor signaling, neuropeptide signaling, enteric nervous system development, grooming behavior, sensory perception of pain). Although a couple terms like saliva secretion and metanephric glomerulus development appear, the overarching theme ties to neural development and dopaminergic signaling networks, suggesting a coherent cluster of dopamine-associated neural signaling processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":23},{"id":"GO:0072224","count":23},{"id":"GO:0060160","count":23},{"id":"GO:0048484","count":23},{"id":"GO:2000458","count":23}]},{"hash":"1433258659402415029","title":"Neuronal signaling and development","description":"This cluster's terms cluster around nervous system function: sensory perception of pain, grooming behavior, neuropeptide signaling, dopaminergic synaptic transmission, and regulation of dopamine receptor signaling, plus astrocyte chemotaxis regulation and enteric nervous system development. A couple of terms about salivary secretion and metanephric glomerulus development appear less central but may reflect autonomic or developmental cross-talk; overall the predominant theme is neural development and neurotransmission, suggesting proteins involved in neuronal signaling networks.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":24},{"id":"GO:0072224","count":24},{"id":"GO:0060160","count":24},{"id":"GO:0048484","count":24},{"id":"GO:2000458","count":24}]},{"hash":"1856568726426348962","title":"Unknown","description":"The top GO terms cover drug response (cocaine, morphine), lung development, inflammatory regulation, metabolism, and meiotic processes, which do not point to a single cohesive biological function for this cluster. The terms appear too diverse to assign a specific, representative label.","confidence":"","size":23,"edges":54,"triangles":47,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006685","count":5},{"id":"GO:0042220","count":5},{"id":"GO:0030324","count":5},{"id":"GO:0043278","count":5},{"id":"GO:0050728","count":5}]},{"hash":"439944079933267410","title":"Neural development and innervation with kidney formation","description":"The cluster\u2019s top GO terms are dominated by developmental processes, especially CNS development and innervation, along with kidney-related development (glomerular filtration and glomerular basement membrane development). A notable term about regulation of FGF receptor signaling supports a role in developmental signaling. While some terms (choline biosynthesis, lipoteichoic acid biosynthesis) are more peripheral, the prevailing theme is tissue development with neural and renal components. ","confidence":"Medium","size":23,"edges":38,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002063","count":5},{"id":"GO:0040037","count":4},{"id":"GO:0014846","count":4},{"id":"GO:0070395","count":4},{"id":"GO:0035860","count":4}]},{"hash":"1101846415552579200","title":"Membrane Microdomains and Junctional Signaling","description":"This cluster centers on membrane organization and signaling, with terms related to lipid rafts/microdomains (membrane raft polarization, eisosome assembly), cell-cell junctions (tight junction assembly, endothelial barrier establishment), and receptor-mediated signaling (extrinsic apoptotic signaling via death receptors, PKC signaling modulation). Some immune and neural terms (B cell differentiation, myelination, sensory perception of sound) likely reflect membrane- and signaling-dependent processes across cell types, reinforcing a membrane-centric theme. Overall, a concise label focusing on membrane organization and signaling fits best.","confidence":"Medium","size":23,"edges":65,"triangles":60,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":9},{"id":"GO:0070830","count":9},{"id":"GO:0002337","count":8},{"id":"GO:0035208","count":8},{"id":"GO:0001766","count":8}]},{"hash":"1582798169643222533","title":"Diverse Metabolite Biosynthesis","description":"The cluster shows strong enrichment for a wide range of biosynthetic processes (phylloquinone, melanin, sphingolipid, fatty acid elongation, glucocorticoid and alkaloid biosynthesis, etc.), indicating a general set of functions tied to synthesizing diverse metabolites rather than a single pathway.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042376","count":23},{"id":"GO:0042619","count":23},{"id":"GO:0042438","count":23},{"id":"GO:0055114","count":23},{"id":"GO:0006704","count":23}]},{"hash":"205362680829689162","title":"Neural development and dopaminergic signaling","description":"The top GO terms are dominated by brain development and regulation of dopamine secretion, suggesting a neural-focused cluster. Additional terms point to related signaling and cellular regulation (e.g., VEGF signaling, GTPase regulation, apoptosis, ribophagy), but the strongest pattern lies in neural development and dopaminergic signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0030948","count":19},{"id":"GO:0043087","count":19},{"id":"GO:0071236","count":18},{"id":"GO:0001302","count":18},{"id":"GO:0043065","count":18}]},{"hash":"731306884562580584","title":"Genome maintenance and cell cycle control","description":"This cluster centers on DNA-templated transcription, RNA polymerase II transcription, DNA replication, and nucleotide-excision repair (including global genome NER), plus mitotic cell cycle and cell division terms. These together define a cohesive genome maintenance/program that coordinates transcription, replication, repair, and division, with ancillary stress-related processes like cadmium response and aggresome assembly reflecting cellular quality control during genome maintenance. ","confidence":"High","size":23,"edges":248,"triangles":1670,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0006366","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0071276","count":5}]},{"hash":"1324064923389453029","title":"Developmental transcription and ribosome biogenesis","description":"The cluster shows strong enrichment for DNA-templated transcription, RNA polymerase II\u2013mediated transcription, and DNA replication, alongside ribosome biogenesis and development-related terms like multicellular organism development and skeletal system development. This points to a coordinated program of gene expression and ribosome production that supports growth and tissue formation, with ER-stress\u2013related apoptotic signaling as a module linking stress response to development. Therefore, the label highlights both transcriptional machinery and ribosome biogenesis in a developmental context.","confidence":"High","size":23,"edges":251,"triangles":1730,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0070059","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0006349","count":5},{"id":"GO:0006260","count":5}]},{"hash":"2059354082106770721","title":"Developmental Regulation and Stress-Responsive Transcription","description":"This cluster centers on transcriptional control intertwined with development (forebrain and multicellular organism development) and cell-cycle/apoptosis signaling, plus stress responses (ER stress\u2013related apoptotic pathway, cadmium response, glucose-limited invasive growth) and GTPase regulation. The mix suggests proteins that coordinate developmental programs with stress signaling and transcriptional regulation rather than a single narrow function.","confidence":"Medium","size":23,"edges":160,"triangles":573,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0030900","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0043547","count":7}]},{"hash":"129133997759334078","title":"Chromatin Regulation and Cell Cycle Control","description":"The cluster centers on nuclear processes: RNA-mediated gene silencing, transcription, chromosome condensation, meiosis, and ubiquitin-related protein turnover, suggesting coordinated chromatin regulation and cell cycle control.","confidence":"Medium","size":23,"edges":169,"triangles":651,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0002089","count":4},{"id":"GO:0007076","count":4},{"id":"GO:0007143","count":3}]},{"hash":"1053706249188164864","title":"Immunometabolic Regulation","description":"This cluster combines immune tolerance and regulation (self-antigen tolerance, negative humoral regulation, IL-6 control, cellular defense) with metabolic and endocrine signaling (glucose homeostasis, insulin signaling, cortisol regulation) and adhesion processes, indicating cross-talk between immune and metabolic pathways in tissue homeostasis or neuroimmune contexts.","confidence":"Medium","size":23,"edges":206,"triangles":1182,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0002513","count":21},{"id":"GO:0042593","count":21},{"id":"GO:0002924","count":21},{"id":"GO:0045409","count":21},{"id":"GO:0008286","count":21}]},{"hash":"1439562877930412877","title":"RNA splicing and ncRNA silencing","description":"The top GO terms cluster around regulatory ncRNA-mediated gene silencing, regulation of mRNA splicing via the spliceosome, mRNA export from the nucleus, and translation initiation. This points to a cohesive role in RNA processing and post-transcriptional gene regulation, including splicing control and ncRNA-mediated silencing mechanisms.","confidence":"High","size":23,"edges":207,"triangles":1056,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":18},{"id":"GO:0048026","count":17},{"id":"GO:1901407","count":16},{"id":"GO:0006406","count":16},{"id":"GO:0000381","count":15}]},{"hash":"1467522771656756812","title":"Developmental Growth and Protein Synthesis","description":"This cluster centers on developmental processes (male gonad/ seminiferous tubule and brain development) alongside core protein synthesis and gene expression machinery (ribosome biogenesis, translation preinitiation complex formation, histone deacetylation) and growth-related activities (cell division, cytoskeletal regulation, and ER-stress\u2013related apoptosis). The blend suggests a cohesive theme around development supported by protein production and chromatin regulation, though the terms span multiple tissues.","confidence":"Medium","size":23,"edges":79,"triangles":118,"max_degree":19,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0008584","count":22},{"id":"GO:0016575","count":21},{"id":"GO:0042254","count":21},{"id":"GO:0001403","count":21},{"id":"GO:0072520","count":21}]},{"hash":"913985238767428675","title":"Hedgehog-driven neural development and cell adhesion","description":"The top terms point to neural and endodermal development (brain development, endodermal differentiation) along with apoptotic processes and clearance, and to adhesion-related activities (cell-matrix adhesion, cell spreading), plus a Smoothened signaling pathway component. Taken together, this suggests a developmental signaling module\u2014centered on Hedgehog signaling\u2014that governs neural development with associated cell adhesion and apoptosis regulation.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":3},{"id":"GO:0043277","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0060313","count":2},{"id":"GO:1900122","count":2}]},{"hash":"875603819437604416","title":"Embryonic morphogenesis and neural development","description":"The top GO terms cluster around developmental processes across embryos and CNS formation: placental branching morphogenesis, axis specification, neural crest migration, cerebellar and Purkinje cell layer development, and endothelial chemotaxis. While proteolysis and complement activation appear, the dominant theme is tissue morphogenesis and neural development, suggesting these proteins participate in embryogenesis and neural patterning.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006508","count":9},{"id":"GO:0060672","count":9},{"id":"GO:0001867","count":9},{"id":"GO:0007313","count":9},{"id":"GO:0048168","count":9}]},{"hash":"1166254651447246598","title":"Complement System and Angiogenesis Regulation","description":"These proteins are enriched for GO terms describing complement activation via classical and alternative pathways, formation and regulation of the membrane attack complex, and related fibrinolysis, indicating a core immune-complement module. In addition, there is substantial representation of angiogenesis regulation (both positive and negative) and embryonic development, suggesting a link between innate immunity and vascular development. A few terms also touch on extracellular matrix organization and neuromuscular processes, consistent with a broader tissue remodeling context.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0042730","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0001701","count":4}]},{"hash":"2136170786172719976","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":243,"triangles":1573,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0044209","count":6},{"id":"GO:0046651","count":5},{"id":"GO:0043103","count":5},{"id":"GO:0032264","count":5},{"id":"GO:0006178","count":5}]},{"hash":"494400206194219842","title":"Thermoception and Pain with Membrane Excitability","description":"The top GO terms show a clear focus on temperature sensing (pain, thermoception, detection of temperature) and thermogenesis, paired with membrane excitability features (potassium transport, hyperpolarization) that are common to excitable tissues like heart and skin. While bone ossification and skin development are also present, they appear less central to the core theme centered on thermal perception and ion-channel\u2013driven excitability.","confidence":"Medium","size":23,"edges":37,"triangles":56,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0002024","count":13},{"id":"GO:0098911","count":12},{"id":"GO:0043931","count":12}]},{"hash":"505289421479941048","title":"Ubiquitin-Dependent Proteostasis and Innate Immunity","description":"The top GO terms cluster around ubiquitin-mediated protein degradation (ubiquitin-dependent proteolysis, polyubiquitination, autoubiquitination, ERAD) and innate immune responses (defense against virus, innate immunity, MHC class I biosynthesis), with some regulatory ties to miRNA silencing and IL-1\u03b2 production. This suggests a cohesive theme where the ubiquitin system links proteostasis to antiviral and immune signaling, despite a miscellaneous outlier term related to synapse assembly.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:0030433","count":16},{"id":"GO:0060386","count":16},{"id":"GO:0045345","count":15},{"id":"GO:0051865","count":15}]},{"hash":"1534372167175879037","title":"Chromatin Regulation and Cytoskeletal Dynamics","description":"The terms indicate epigenetic regulation (DNA-templated transcription, H3K9 methylation) and protein homeostasis via ubiquitin/proteasome pathways, coupled with cytoskeletal dynamics (actin organization, GTPase signaling) and cell movement, plus a hypoxia response. Together they point to a functional cluster where chromatin-level transcription control interfaces with cytoskeletal remodeling and signaling, consistent with coordinated regulation of gene expression and cell motility under stress.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0051567","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0016477","count":4}]},{"hash":"835193748116946892","title":"Golgi trafficking and NF-kappaB immune signaling","description":"The cluster centers on Golgi organization and vesicular transport (Golgi to plasma membrane, transport along microtubules, retrograde axonal transport), indicating a role in Golgi-dependent protein trafficking. Concurrently, several immune-related terms appear (defense response to virus, responses to IL-1 and TNF, and canonical NF-kappaB signaling), suggesting involvement in NF-kappaB\u2013mediated immune pathways that may intersect with trafficking processes. This combination points to a cohesive theme of Golgi-based trafficking linked to immune signaling functions.","confidence":"Medium","size":23,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0047496","count":2},{"id":"GO:0043001","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0007030","count":2},{"id":"GO:0008090","count":2}]},{"hash":"812450257842379145","title":"Cranial Nerve Development and Axon Guidance","description":"Most terms point to axon guidance and nerve development, including branchiomotor neuron axon guidance, sensory neuron axon guidance, facial and trigeminal nerve organization, and semaphorin-plexin signaling. Neural crest migration and autonomic nervous system development terms also align with cranial nerve formation. Overall, the cluster reflects neural pathfinding and cranial nerve patterning.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0060666","count":8},{"id":"GO:0048843","count":8},{"id":"GO:0021785","count":8},{"id":"GO:1902287","count":8},{"id":"GO:0021612","count":8}]},{"hash":"873951341406050955","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:1904751","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0032211","count":1},{"id":"GO:0051096","count":1}]},{"hash":"583316690661229251","title":"Microvillus and brush-border assembly with Rho/Rac signaling","description":"This cluster is dominated by GO terms related to microvillus and brush-border assembly (microvillus assembly, follicle cell microvillus organization, brush border assembly) and cytoskeletal regulation (negative regulation of GTPase activity, regulation of Rac/Rho signaling, filopodium assembly). The common thread is epithelial microvilli formation and actin cytoskeleton remodeling mediated by Rho family GTPases, with some ancillary terms like equilibrioception and hair follicle maturation likely reflecting broader sensory/cutaneous contexts.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1904970","count":4},{"id":"GO:0050957","count":4},{"id":"GO:0070493","count":4},{"id":"GO:0035021","count":4},{"id":"GO:0030033","count":4}]},{"hash":"2059505960681695791","title":"Vascular development and angiogenesis","description":"The top GO terms are heavily skewed toward vascular biology: blood coagulation, endothelial cell differentiation, and sprouting angiogenesis, plus cell-matrix adhesion underpinning vessel formation. While other terms reflect broader development (BMP signaling regulation, organ development) the strongest shared theme across the cluster is endothelial/vascular development and remodeling.","confidence":"High","size":23,"edges":24,"triangles":15,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":14},{"id":"GO:0030514","count":13},{"id":"GO:0001657","count":13},{"id":"GO:0007605","count":13},{"id":"GO:0007160","count":13}]},{"hash":"797483936406944240","title":"Small GTPase-driven actin cytoskeleton remodeling","description":"This cluster is dominated by GO terms for activation of GTPase activity and small GTPase-mediated signaling, along with actin cytoskeleton organization, pointing to coordinated regulation of cytoskeletal dynamics by GTPases (e.g., Rho family). Other terms related to lipid transport or development appear less cohesive with the core theme. Confidence: High","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":4},{"id":"GO:2001275","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0044128","count":3},{"id":"GO:0007507","count":3}]},{"hash":"2205919600938167093","title":"Blood Coagulation and Immune Defense","description":"The prominent GO terms include fibrinolysis, blood coagulation, defense response to Gram-positive bacteria, and response to heparin, pointing to a core cluster around hemostasis and innate immunity. Additional terms like BMP signaling regulation, PI3K signaling, transcytosis, and cholinergic synaptic transmission suggest broader regulatory or transport roles that may accompany vascular or immune contexts. Overall, the cluster seems centered on coagulation/hemostasis with supporting immune and signaling functions.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":6},{"id":"GO:0042730","count":6},{"id":"GO:0030514","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0050830","count":4}]},{"hash":"1512057692929890708","title":"Immune signaling and developmental regulators","description":"This cluster features immune signaling terms (non-canonical NF-kappaB, IL-6 production, LPS signaling, TH1 response) along with development/differentiation terms (bone and fat cell development, axis specification). The mix suggests proteins that regulate signaling pathways with developmental roles, rather than a single, cohesive pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042346","count":4},{"id":"GO:0060348","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0090141","count":4},{"id":"GO:0045410","count":4}]},{"hash":"1595567970947180684","title":"Neural development and synapse formation","description":"This cluster is dominated by GO terms related to nervous system development and synapse assembly (e.g., positive regulation of synapse assembly, nervous system development, multicellular organism development). It also includes signaling pathways commonly involved in neural differentiation and synaptic regulation (ERK/MAPK cascade, PI3K signaling, STAT phosphorylation, VEGF/PDGF receptor signaling). A few terms touch on innate immune response, which can intersect neuroimmune contexts but does not outweigh the neural-development signature. Overall, the proteins appear to function together in neural development and synaptic organization.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":8},{"id":"GO:0007275","count":7},{"id":"GO:0007399","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0014068","count":6}]},{"hash":"941310968726495767","title":"Immune adhesion and tissue remodeling","description":"This cluster heavily features cell-cell adhesion (both heterophilic and homophilic), complement activation (classical pathway), adaptive immune response, and processes linked to tissue remodeling and vascular changes (angiogenesis, epithelial maintenance, skeletal development, wound healing). Taken together, this suggests a module of immune cells interacting with tissues to promote inflammation, adhesion, and remodeling. The presence of one mechanosensory term is an outlier rather than central to the theme. ","confidence":"Medium","size":23,"edges":52,"triangles":29,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0006958","count":8},{"id":"GO:0050910","count":7},{"id":"GO:0001525","count":6},{"id":"GO:0030277","count":6}]},{"hash":"1921186389051805899","title":"Vertebrate organogenesis","description":"The cluster is strongly enriched for organ development terms across multiple tissues (pancreas morphogenesis, digestive system development, midbrain development, post-embryonic development) and includes regulatory transcriptional and signaling-related GO terms, suggesting a coherent module of genes involved in vertebrate organ formation and growth.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061113","count":22},{"id":"GO:0009791","count":22},{"id":"GO:0035264","count":22},{"id":"GO:0045944","count":22},{"id":"GO:0003050","count":22}]},{"hash":"61377085953747702","title":"Vascular coagulation and lipid transport signaling","description":"The top GO terms cluster around coagulation and fibrinolysis (response to heparin, fibrinolysis, urokinase signaling) and lipid processing (lipoprotein lipase activity, chylomicron remnant clearance) with associated transcytosis, suggesting a vascular/endothelial role in hemostasis and lipid transport. Some terms like cholinergic synaptic transmission and locomotory behavior appear more broadly annotated and may reflect pleiotropy rather than core function. The absence of network edges supports a functional annotation grouping rather than a tight interaction hub.","confidence":"Low","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071503","count":5},{"id":"GO:0043388","count":5},{"id":"GO:0042730","count":5},{"id":"GO:2001243","count":5},{"id":"GO:0045056","count":5}]},{"hash":"2300891430132143876","title":"Ion Channels and Cardiac Excitability","description":"The top GO terms cluster around membrane transport and electrical signaling: potassium and sodium ion transmembrane transport, regulation of synaptic transmission (glutamatergic), atrial cardiac muscle cell action potential, and regulation of heart rate by cardiac conduction. These point to membrane excitability and electrophysiology in neurons and the heart. A few outlier terms (cell wall/macromolecule catabolism, defense responses) appear peripheral, likely noise rather than core cluster functions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0051966","count":3},{"id":"GO:0016998","count":3},{"id":"GO:0019076","count":3},{"id":"GO:0009253","count":3}]},{"hash":"421825117416780479","title":"Amino Acid Metabolism and NADPH Regeneration","description":"The cluster is enriched for multiple amino acid pathways (valine, alanine, serine) with both catabolic and biosynthetic processes, along with NADPH regeneration and a starvation response. This suggests a cohesive metabolic module focused on amino acid turnover and redox balance under nutrient stress.","confidence":"High","size":23,"edges":76,"triangles":92,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0006574","count":6},{"id":"GO:0042853","count":5},{"id":"GO:0006740","count":5},{"id":"GO:0042594","count":4}]},{"hash":"2156438072649217591","title":"Developmental patterning and organogenesis","description":"This cluster's top GO terms cluster around embryonic and organ development across multiple lineages\u2014left/right pattern formation; endocardial cushion EMT; placenta-related differentiation; cartilage morphogenesis; pancreatic beta-cell development; endocrine system development\u2014indicating a cohesive theme of developmental patterning and tissue specification.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060707","count":6}]},{"hash":"1327505678450011269","title":"Amino acid biosynthesis and iron transport","description":"The cluster shows strong representation of amino acid biosynthesis terms (pyruvate, threonine, serine, transsulfuration, and even obsolete isoleucine biosynthesis) suggesting metabolic enzymes involved in amino acid production. Added terms for transferrin transport, iron import, and iron homeostasis indicate concurrent involvement in iron uptake/handling, implying a grouping that mixes amino acid biosynthetic capacity with iron transport/homeostasis components. This combination provides a coherent, if broad, functional theme for the cluster.","confidence":"Medium","size":23,"edges":16,"triangles":4,"max_degree":4,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042866","count":5},{"id":"GO:0009097","count":5},{"id":"GO:0009088","count":5},{"id":"GO:0019346","count":5},{"id":"GO:0055114","count":5}]},{"hash":"2123920677841213243","title":"Embryonic development and organogenesis","description":"The top GO terms cluster around embryonic patterning and multi-tissue organ formation, including left/right patterning, heart development, placenta/ trophoblast differentiation, cartilage morphogenesis, and pancreatic cell development, with supporting general cellular processes. This points to a cohesive theme of embryogenesis and organogenesis.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":9},{"id":"GO:0035270","count":9},{"id":"GO:0003198","count":9},{"id":"GO:0060806","count":9},{"id":"GO:0060536","count":9}]},{"hash":"279931009259425275","title":"JAK-STAT\u2013mediated immune signaling and cell adhesion","description":"This set shows strong representation of positive regulation of STAT tyrosine phosphorylation (JAK-STAT signaling), along with immune-regulatory processes such as regulation of cytotoxic T cell degranulation and NK cell activity, macrophage activation, and synapse/adhesion-related terms. The convergence on cell-cell adhesion and synapse assembly supports coordination of immune cell interactions, while symbiont entry into host cell suggests involvement in host-microbe interfaces. Together these themes point to a network of signaling and adhesion guiding immune responses.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042511","count":14},{"id":"GO:0042517","count":14},{"id":"GO:0046718","count":14},{"id":"GO:0090138","count":14},{"id":"GO:0086072","count":14}]},{"hash":"934557535980542216","title":"Vertebrate neural and eye development","description":"The cluster is strongly enriched for neural and sensory organ formation terms (peripheral nervous system neuron development, motor neuron axon guidance, brain segmentation, camera-type eye development), pointing to vertebrate neural patterning and eye organogenesis during embryogenesis. While there are broader embryonic development signals (e.g., primitive streak formation, metanephric mesenchyme development), the dominant theme is neural and eye development. ","confidence":"High","size":23,"edges":250,"triangles":1709,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":17},{"id":"GO:0090009","count":16},{"id":"GO:0048935","count":16},{"id":"GO:0008045","count":16},{"id":"GO:0035284","count":16}]},{"hash":"105702901853081496","title":"Developmental Patterning and Organogenesis","description":"These proteins map to embryonic development and tissue formation: left/right patterning, heart cushion EMT, cartilage morphogenesis, placental and pancreatic endocrine development, rhombomere specification, and broader endocrine development. Transcriptional regulation (DNA-templated transcription) underpins these programs, with ER stress responses (PERK-mediated UPR) sometimes involved during development. The unifying theme is developmental patterning and organogenesis across multiple tissues.","confidence":"High","size":23,"edges":45,"triangles":41,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0060972","count":8},{"id":"GO:0036499","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003198","count":7}]},{"hash":"2026401456236259466","title":"Embryonic development and morphogenesis","description":"The top GO terms predominantly describe developmental and morphogenetic processes across various organs and tissues (left/right patterning, endocardial cushion EMT, placenta development, cartilage morphogenesis, palate roof development, pancreatic endocrine development), indicating a cohesive theme of embryogenesis and organ formation. Some terms are more general (e.g., ribosomal export) and less central to development, but the overall signal supports organogenesis and morphogenesis as the cluster\u2019s core function. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0060707","count":8}]},{"hash":"2169188594920646693","title":"Mammary gland epithelial proliferation and lactation","description":"The cluster is dominated by terms tied to cell cycle progression and proliferation (G1/S transition, cell division, positive regulation of CDK activity) and specifically mammary gland epithelial proliferation and lactation, suggesting proteins that promote epithelial growth in the mammary gland and its lactation-related functions. Some outlier terms (meiosis pairing, multi-ciliated differentiation) may reflect shared components or broader annotation coverage, but the predominant theme centers on mammary epithelial cell proliferation regulated by CDK signaling.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007129","count":5},{"id":"GO:0000320","count":4},{"id":"GO:0033598","count":4},{"id":"GO:0045737","count":4},{"id":"GO:0051301","count":4}]},{"hash":"293995650775343961","title":"Unknown","description":"The terms span calcium signaling and cardiac function (calcium concentration, heart rate, heart contraction, cardiac conduction) together with craniofacial development (roof of mouth development, face morphogenesis) and even neutrophil chemotaxis, plus several obsolete annotations. There is no single coherent function tying all 23 proteins; the lack of edges and the mix of developmental, immune, and cardiac terms point to annotation noise rather than a unified pathway. Confidence in a single representative theme is therefore None. ","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051482","count":3},{"id":"GO:0030593","count":3},{"id":"GO:0010460","count":3},{"id":"GO:0060047","count":2},{"id":"GO:0060021","count":2}]},{"hash":"935283497924196605","title":"Mitochondrial fusion in brown fat development","description":"The cluster\u2019s top GO terms are dominated by mitochondrial fusion and regulation of mitochondrial fusion, together with brown fat cell differentiation, pointing to a theme of mitochondrial dynamics supporting brown adipocyte development and associated lipid remodeling. Secondary terms related to lipid metabolism and retinoid signaling (retinol and retinoic acid biosynthesis) further support adipose/lipid-associated functions, though some terms (bone development, antibiotic biosynthetic process) are more peripheral. Overall, the motif centers on mitochondrial fusion linked to brown fat differentiation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010635","count":3},{"id":"GO:0008053","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0050873","count":2},{"id":"GO:0042619","count":2}]},{"hash":"552012240107016121","title":"Embryonic Development and Morphogenesis","description":"The top GO terms point to a suite of embryonic differentiation and morphogenetic processes: left\u2013right patterning, endocrine system development, epithelial-to-mesenchymal transition in heart cushion formation, placenta/trophoblast differentiation, cartilage morphogenesis, and pancreatic cell development, indicating a cohesive theme of developmental tissue formation and specialization.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060707","count":5}]},{"hash":"1471458240649752120","title":"Embryonic Brain and Organ Morphogenesis","description":"This cluster shows strong enrichment for GO terms tied to embryonic development across multiple organs, including brain development, neurohypophysis development, cranial skeleton morphogenesis, digit morphogenesis, ureteric bud/kidney morphogenesis, and heart-related structure development. While a couple of terms are more general (regulation of binding, behavior), the dominant theme is embryonic morphogenesis across diverse tissues, making \"Embryonic Brain and Organ Morphogenesis\" a representative label.","confidence":"High","size":23,"edges":182,"triangles":818,"max_degree":22,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051098","count":23},{"id":"GO:0044708","count":23},{"id":"GO:0021985","count":23},{"id":"GO:0090190","count":23},{"id":"GO:0007420","count":23}]},{"hash":"223874735625786245","title":"Neural development and myelination","description":"This cluster centers on nervous system development and neuron\u2013glia interactions, with terms like myelination, regulation of axon diameter, and skeletal muscle fiber development pointing to nervous/muscle-neural interfaces. Also included are apoptotic cell clearance processes (phosphatidylserine exposure, engulfment of apoptotic cells), suggesting glial phagocytosis roles during neural development. Additional terms cover general cellular logistics (lipid metabolism, ER-to-Golgi transport) that support neural cell functions. A plant-specific brassinosteroid term appears as a minor, likely non-core annotation. Overall, the cohesive theme is neural development and myelination with associated cell-clearance processes.","confidence":"Medium","size":22,"edges":225,"triangles":1424,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0010961","count":3},{"id":"GO:0070782","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0043652","count":3}]},{"hash":"632463643301535865","title":"Nucleolar RNA Processing and Ribosome Biogenesis","description":"Most prominent terms point to box C/D snoRNP assembly, i.e., nucleolar RNA processing for ribosome biogenesis, along with proteostasis pathways (ubiquitin-dependent protein catabolic process, response to unfolded protein). The presence of mitotic cell cycle terms suggests coordination with cell division, reinforcing a nuclear/nucleolar focus on ribosome production and protein quality control. Some terms related to steroid hormone receptor assembly and development may reflect broader nuclear signaling connections rather than core function of the cluster.","confidence":"Medium","size":22,"edges":101,"triangles":222,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000492","count":12},{"id":"GO:0006986","count":12},{"id":"GO:0000278","count":12},{"id":"GO:0051348","count":12},{"id":"GO:0006463","count":12}]},{"hash":"1248320050376690573","title":"Neural development and ER network organization","description":"The Top Terms show a strong emphasis on neural development processes (branching morphogenesis of nerves, axon extension regulation, axonal fasciculation, radial glia-guided migration) along with structural ER features (ER tubular network formation/maintenance, ER membrane organization) and nuclear pore complex assembly, suggesting proteins involved in neuronal morphogenesis linked with ER architecture. Some terms like steroid biosynthesis or EMT are less central but do not override the neural-ER theme. Confidence: High","confidence":"","size":22,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000172","count":3},{"id":"GO:0071787","count":3},{"id":"GO:0071788","count":3},{"id":"GO:0051292","count":3},{"id":"GO:0060317","count":3}]},{"hash":"58978496318552020","title":"Unknown","description":"The Top Terms span highly divergent functions (bile acid transport, plant immune response, pain perception, magnesium homeostasis, ER-to-cytosol transport, pH stress response, cAMP signaling, pantothenate synthesis, and cuticle development) across likely different species, with no clear overarching theme. This diversity suggests no cohesive functional signature for the cluster, so the label Unknown with no confidence is most appropriate.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015721","count":2},{"id":"GO:0009626","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0010961","count":2},{"id":"GO:1904211","count":2}]},{"hash":"1870301766462364837","title":"Developmental transcriptional regulators","description":"The top GO terms cluster around DNA-templated transcription and multicellular development (forebrain, skeletal system), suggesting proteins that act as transcriptional regulators guiding development. While some terms touch on cell cycle and stress responses, the predominant signal is developmental gene regulation.","confidence":"High","size":22,"edges":225,"triangles":1426,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":14},{"id":"GO:0006349","count":12},{"id":"GO:0007275","count":12},{"id":"GO:0000278","count":8},{"id":"GO:0001403","count":7}]},{"hash":"1183312314418594967","title":"Neuronal development and vesicle trafficking","description":"The cluster shows enrichment for neuron development, anterograde synaptic vesicle transport, and tubulin/cytoskeletal assembly, indicating functions in neuronal differentiation and vesicle trafficking; references to transcriptional complex assembly and protein folding appear more general and do not outweigh the neural theme.","confidence":"High","size":22,"edges":106,"triangles":241,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0007021","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0048666","count":2}]},{"hash":"220566278792451853","title":"Chromatin Regulation and Protein Processing","description":"The cluster strongly features chromatin-related processes (histone acetylation/deacetylation, DNA-templated transcription) and ribosome biogenesis (rRNA maturation), indicating regulation of gene expression. It also includes protein maturation/trafficking activities (ER-to-Golgi transport, ERAD) and development-related terms (skin development), suggesting a broader theme of gene expression control coupled with protein processing during development.","confidence":"Medium","size":22,"edges":167,"triangles":755,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043966","count":15},{"id":"GO:0006888","count":15},{"id":"GO:0016575","count":15},{"id":"GO:0051301","count":15},{"id":"GO:0032933","count":15}]},{"hash":"145601388275700665","title":"RNA processing, transcription, and translation in proliferating cells","description":"This cluster is enriched for RNA metabolism and protein synthesis processes, including mRNA splicing, non-stop and nonsense-mediated decay, transcription elongation, and translation, alongside cell-cycle\u2013related proliferation terms. Together these GO terms point to a cohesive set of gene-expression machinery active during cell division.","confidence":"High","size":22,"edges":173,"triangles":732,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":5},{"id":"GO:0070481","count":5},{"id":"GO:0070651","count":5},{"id":"GO:0006368","count":4},{"id":"GO:0051301","count":4}]},{"hash":"50878363784763708","title":"Neuronal vesicle trafficking and development","description":"The cluster shows strong signals for intracellular protein transport, clathrin-dependent endocytosis, and synaptic vesicle coating, pointing to vesicle trafficking in neurons. Additional terms like cerebral cortex development and regulation of synaptic plasticity and apoptosis suggest broader neuronal development and signaling roles that accompany vesicle dynamics.","confidence":"Medium","size":22,"edges":18,"triangles":18,"max_degree":7,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":7},{"id":"GO:0072583","count":4},{"id":"GO:0016183","count":4},{"id":"GO:0043065","count":4},{"id":"GO:0021987","count":4}]},{"hash":"1921348698711557033","title":"Developmental gene regulation and stress response","description":"The top GO terms are dominated by DNA-templated transcription and multiple developmental processes (forebrain development, neural tube closure, skeletal system development, multicellular organism development), pointing to regulatory proteins that govern development. Added stress-related terms (intrinsic apoptotic signaling in response to ER stress, cellular response to cadmium ion, invasive growth in response to glucose limitation) suggest these proteins also participate in cellular stress responses that can intersect with development. Overall, the cluster appears to reflect transcriptional regulation guiding development with concurrent stress response roles.","confidence":"Medium","size":22,"edges":99,"triangles":147,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0006349","count":5},{"id":"GO:0070059","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0001501","count":4}]},{"hash":"1589599430629648511","title":"Developmental Signaling and Cell Migration","description":"This cluster centers on signaling pathways that regulate movement and morphogenesis (cell migration, Rho and ephrin signaling, PI3K activity) and tissue development (heart development, dendritic spine morphogenesis), with immune-related signals (IL-7 response, B cell maturation) suggesting coordinated signaling in development and immunity.","confidence":"Medium","size":22,"edges":228,"triangles":1481,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016477","count":13},{"id":"GO:0007507","count":12},{"id":"GO:0008286","count":12},{"id":"GO:2001275","count":11},{"id":"GO:0035023","count":11}]},{"hash":"503542352849639445","title":"Vertebrate neural and cardiac development via transcription","description":"The top GO terms cluster around DNA-templated transcription and development of neural tissues (cerebellar cortex, hippocampus) and heart, suggesting a set of proteins that regulate transcription during vertebrate neural and cardiac development. Other terms (telomere maintenance, membrane tubulation, phosphorylation, and cell migration) align with broader regulatory roles but do not outweigh the central developmental/transcription theme. ","confidence":"Medium","size":22,"edges":19,"triangles":8,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0021695","count":3},{"id":"GO:0043433","count":3},{"id":"GO:0033138","count":3}]},{"hash":"987685125824668071","title":"Neural signaling, photoreception, and ion transport","description":"The top GO terms cluster around neuronal signaling and sensory processes: GPCR signaling linked to glutamate receptors, calcium and sodium ion transport, photoreception and visual perception, and cellular responses to electrical stimuli, with an additional hint of memory processes. The inclusion of electron transport chain terms suggests neuronal energy requirements. Some outliers (fungicide response, oocyte maturation regulation) are likely annotation noise, but the dominant theme points to neural signaling and sensory function.","confidence":"Medium","size":22,"edges":47,"triangles":25,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":22},{"id":"GO:0035725","count":22},{"id":"GO:0030818","count":22},{"id":"GO:0060992","count":22},{"id":"GO:0090280","count":22}]},{"hash":"1799081117067230599","title":"Chromatin regulation and centrosome-spindle dynamics","description":"The cluster includes GO terms tied to chromatin regulation (negative regulation of transcription by RNA polymerase II and histone modifications) and cell division structures/processes (spindle assembly, centrosome cycle). Although some terms are obsolete and there is an aggresome-related term, the overarching pattern points to chromatin state influencing mitotic machinery. Confidence: Medium","confidence":"","size":22,"edges":25,"triangles":6,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0051225","count":6},{"id":"GO:0061188","count":6},{"id":"GO:0007098","count":6},{"id":"GO:0098532","count":6}]},{"hash":"2157103193863921599","title":"Pro-angiogenic endothelial signaling","description":"The top terms cluster around promoting angiogenesis and endothelial cell behavior, including positive regulation of angiogenesis, endothelial cell migration, and actin cytoskeleton remodeling, supported by Rho signaling and ERK/MAPK cascades. Serine phosphorylation regulation also ties into signaling controlling these processes. A few terms refer to unrelated contexts (glial survival, synaptic plasticity, thyroid development), but the dominant theme is pro-angiogenic signaling in endothelial cells. ","confidence":"High","size":22,"edges":40,"triangles":10,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045766","count":12},{"id":"GO:0031532","count":11},{"id":"GO:0070374","count":11},{"id":"GO:0033138","count":11},{"id":"GO:0043536","count":11}]},{"hash":"561218268206067288","title":"Transcriptional and chromatin regulation","description":"This cluster's top terms point to transcriptional control and chromatin/epigenetic processes (negative regulation of RNA Pol II transcription, histone deacetylase activity, ncRNA transcription, and heterochromatin formation). While a few terms touch on development or signaling, the overall theme is regulation of gene expression via transcriptional and chromatin mechanisms.","confidence":"High","size":22,"edges":104,"triangles":198,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:1901726","count":4},{"id":"GO:0070562","count":4},{"id":"GO:2001040","count":4},{"id":"GO:0048655","count":4}]},{"hash":"1774627908676380106","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":36,"triangles":20,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000463","count":7},{"id":"GO:0016575","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0006351","count":6}]},{"hash":"1985913380637557280","title":"Epigenetic regulation of neural development","description":"The proteins cluster around neural development and plasticity, with cerebellum development, learning (visual learning), and fear-related behaviors, and show epigenetic control via DNA methylation and histone modifications, indicating a module of neural gene expression and synaptic signaling.","confidence":"High","size":22,"edges":65,"triangles":52,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001662","count":5},{"id":"GO:0006349","count":5},{"id":"GO:0021549","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0051301","count":4}]},{"hash":"1671723750199995027","title":"RNA processing and translational regulation","description":"This cluster centers on post-transcriptional RNA regulation, with frequentGO terms for mRNA splicing via the spliceosome, regulation of mRNA stability in response to stress, mRNA export from the nucleus, and translation initiation plus miRNA-mediated silencing. The convergence of splicing, stability, export, and translational control suggests a coherent theme of RNA metabolism and gene expression control at the RNA level.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":22},{"id":"GO:0000381","count":13},{"id":"GO:0048026","count":13},{"id":"GO:1900363","count":13},{"id":"GO:0031047","count":13}]},{"hash":"794653526704771732","title":"Mitotic Cell Cycle and Cytokinesis Regulation","description":"Most top GO terms center on cell division and the mitotic cycle (cell division, mitotic cell cycle, exit from mitosis) and division septum assembly, suggesting a common role in cytokinesis and mitotic progression, with supporting processes like ubiquitination, heterooligomerization, and polarity maintenance.","confidence":"High","size":22,"edges":68,"triangles":77,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":20},{"id":"GO:0000278","count":20},{"id":"GO:0046330","count":18},{"id":"GO:0000917","count":18},{"id":"GO:0000055","count":18}]},{"hash":"1131726373248199497","title":"Glycoprotein glycosylation and AGP metabolism","description":"The cluster shows strong signals for hydroxyproline O-glycosylation, arabinogalactan protein (AGP) metabolism, and related glycosylation processes (e.g., poly-N-acetyllactosamine biosynthesis, seed mucilage), suggesting a core theme of cell-surface glycoprotein and cell-wall polysaccharide biosynthesis, mainly plant-focused. Some terms about epithelial polarity and insect development hint broader roles, but the dominant pattern is AGP-related glycosylation and surface matrix formation.","confidence":"Medium","size":22,"edges":224,"triangles":1416,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":7},{"id":"GO:0018258","count":6},{"id":"GO:0007299","count":6},{"id":"GO:0048354","count":6},{"id":"GO:0010493","count":6}]},{"hash":"1673099003402218189","title":"Actin Cytoskeleton and Sarcomere Assembly","description":"The dominant GO terms center on actin-related processes (actin crosslink formation, sarcomere organization) and muscle development (skeletal muscle fiber development), with Rho signaling regulation linking to cytoskeletal dynamics. A couple of terms about fungal development appear as potential noise, but the core signal points to actin-based cytoskeletal organization and sarcomere/muscle assembly.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0030437","count":4},{"id":"GO:0070493","count":4},{"id":"GO:0000742","count":4},{"id":"GO:1902896","count":4}]},{"hash":"305426643902615327","title":"Neural development and synaptic signaling","description":"The cluster shows a clear emphasis on nervous system development and synaptic function, including axonogenesis, long-term potentiation, excitatory postsynaptic potential, Schwann cell development, and visual perception, with supporting terms for phosphorylation signaling and cell-cycle regulation, suggesting a cohesive group of proteins involved in neural development and synaptic activity.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010800","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0014044","count":7},{"id":"GO:0007601","count":7},{"id":"GO:0000278","count":7}]},{"hash":"1510355309178577416","title":"Telomere maintenance and telomeric regulation","description":"Dominant telomere-related terms (telomere maintenance, capping, telomeric DNA binding, lengthening) with chromosome localization and ADP-ribosylation, plus some mitotic context (spindle assembly/cohesion).","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048745","count":3},{"id":"GO:0070198","count":3},{"id":"GO:1904908","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0016055","count":3}]},{"hash":"779918211618699587","title":"GTPase-Regulated Signaling and Actin Remodeling","description":"The cluster is centered on small GTPase\u2013mediated signaling (Rab, Rap, GTPase activity) and actin cytoskeleton organization, with supporting links to growth factor receptor signaling (IGF pathway). The presence of negative regulation motifs (e.g., JNK cascade, neutrophil degranulation) suggests coordinated modulation of signaling and cytoskeletal dynamics, making GTPase-driven signaling and actin remodeling the most coherent theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048009","count":5},{"id":"GO:0030036","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0060313","count":4},{"id":"GO:0043314","count":4}]},{"hash":"414840273557995930","title":"Ubiquitin-Dependent Protein Turnover and ERAD","description":"This cluster is dominated by ubiquitination and degradation-related GO terms (autoubiquitination, ubiquitin-dependent protein catabolic process, K48-linked ubiquitination, and ERAD), indicating components of the ubiquitin-proteasome system and ER-associated degradation. Additional terms like peroxisomal import and receptor catabolic processes, along with signaling regulation, fit within the broader theme of protein turnover regulating growth and signaling.","confidence":"High","size":22,"edges":80,"triangles":138,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":8},{"id":"GO:0042787","count":8},{"id":"GO:0046621","count":7},{"id":"GO:0070936","count":7},{"id":"GO:0030433","count":7}]},{"hash":"2285752796066178289","title":"GTPase Signaling and Cytoskeletal Transport","description":"The cluster is dominated by GO terms related to small GTPase signaling (Rho, Rap, Ras), activation and regulation of GTPase activity, and intracellular transport/localization to the cortical microtubule cytoskeleton, suggesting proteins that coordinate GTPase-driven signaling with cytoskeletal dynamics and vesicle transport.","confidence":"High","size":22,"edges":7,"triangles":0,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":6},{"id":"GO:0035023","count":4},{"id":"GO:0032486","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0090630","count":3}]},{"hash":"1152011813592937533","title":"Ubiquitination and ERAD-mediated signaling","description":"The cluster is dominated by ubiquitination-related GO terms: autoubiquitination, K63-linked ubiquitination, and the ubiquitin-dependent ERAD pathway, pointing to a core function in protein quality control and targeted degradation. Additional terms implicate regulation of the JNK cascade and apoptotic processes, suggesting this set of proteins participates in stress-responsive signaling linked to cell fate via ubiquitin-mediated pathways. Some terms are obsolete, and V(D)J recombination is peripheral, but the prevailing theme remains ubiquitination- and degradation-centered.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":22},{"id":"GO:0090073","count":22},{"id":"GO:0033151","count":22},{"id":"GO:1903762","count":22},{"id":"GO:0070534","count":22}]},{"hash":"1231580255719081159","title":"Developmental signaling and pattern formation","description":"The top GO terms cluster around developmental processes and patterning, including left-right pattern formation, prostate gland development, Wnt signaling, and differentiation, suggesting a function in developmental signaling and tissue patterning. The presence of actin remodeling and ubiquitin-dependent proteolysis indicates accompanying cytoskeletal and proteostasis regulation during morphogenesis, reinforcing a cohesive theme of development-driven signaling and patterning.","confidence":"Medium","size":22,"edges":8,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060743","count":6},{"id":"GO:0060972","count":5},{"id":"GO:0000083","count":5},{"id":"GO:0032088","count":5},{"id":"GO:0016049","count":5}]},{"hash":"1315035926272419831","title":"Monosaccharide catabolism","description":"This cluster is dominated by GO terms for the catabolic processing of various monosaccharides (fucose, arabinose, rhamnose, lyxose, ascorbic acid, etc.), suggesting a cohesive function in sugar breakdown. A few terms (pyroptotic inflammatory response, left/right pattern formation) appear unrelated and may reflect annotation noise. Despite the lack of observed edges, the prevalent metabolic theme justifies labeling it as Monosaccharide Catabolism.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042355","count":5},{"id":"GO:0019571","count":5},{"id":"GO:0019301","count":5},{"id":"GO:0070269","count":5},{"id":"GO:0019284","count":5}]},{"hash":"924217576154331041","title":"Immune differentiation and ubiquitin regulation","description":"The dominant signals are GO terms for adaptive immune cell differentiation (memory T cell differentiation, dendritic cell differentiation, germinal center formation) along with ubiquitin-related processes (negative regulation of ubiquitination and ubiquitin-dependent protein catabolic process). This suggests a cluster centered on immune cell development with protein turnover control. While a few terms point to broader developmental or circadian roles, they are less represented, so the label focuses on immune differentiation with ubiquitin pathways.","confidence":"Medium","size":22,"edges":88,"triangles":102,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0043380","count":4},{"id":"GO:0031397","count":4},{"id":"GO:2001200","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0042748","count":4}]},{"hash":"1892759344290093691","title":"Bone/cartilage formation and vascular development","description":"The top GO terms focus on chondrocyte and osteoblast differentiation, BMP signaling, and growth-factor\u2013driven regulation (ERK cascade), along with heart and vascular development (atrioventricular valve morphogenesis, endothelial cell migration, chorio-allantoic fusion). This pattern indicates coordinated skeletal tissue formation with accompanying vascularization, under BMP/ERK signaling control. ","confidence":"High","size":22,"edges":209,"triangles":1191,"max_degree":21,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0070374","count":13},{"id":"GO:0003181","count":13},{"id":"GO:0002062","count":13},{"id":"GO:0045669","count":13},{"id":"GO:0060710","count":13}]},{"hash":"1457327725373106902","title":"Neural signaling and sensory processing","description":"This cluster centers on neural signaling and sensory perception, highlighted by terms for visual light detection, cellular response to electrical stimuli, and glutamate receptor\u2013linked GPCR signaling. Ion transport (sodium, calcium) and electron transport chain terms point to neuronal excitability and energy needs, while memory term aligns with neural function. The presence of an oocyte maturation regulator term likely reflects shared signaling components rather than a neuron-specific role. Overall, the dominant theme is neuronal signaling and sensory processing.","confidence":"High","size":22,"edges":226,"triangles":1446,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":22},{"id":"GO:0035725","count":22},{"id":"GO:0030818","count":22},{"id":"GO:0060992","count":22},{"id":"GO:0090280","count":22}]},{"hash":"755578009978793689","title":"Regulated Rho/Ras signaling and cell migration","description":"This cluster centers on regulation of small GTPase pathways (Rho, Ras) and processes tied to cell movement and development, including cell migration, acrosome reaction, and heart/blood vessel remodeling, with supporting signals from synaptic vesicle priming and neutrophil degranulation. The common theme is modulation of signaling that governs motility and developmental transitions, though some terms reflect broader signaling contexts.","confidence":"Medium","size":22,"edges":9,"triangles":0,"max_degree":6,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0016082","count":4},{"id":"GO:0007340","count":4},{"id":"GO:0046580","count":4},{"id":"GO:0060313","count":4}]},{"hash":"774207650086192132","title":"Neural differentiation and actin cytoskeleton dynamics","description":"The terms cluster around neural development (Purkinje cell differentiation, motor neuron migration) and cytoskeletal regulation (Rho/GTPase signaling, actin filament bundle assembly), suggesting proteins that coordinate neural differentiation with cytoskeletal remodeling. A few terms reference other organ development, but the dominant theme is neural development paired with cytoskeletal dynamics.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0048712","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0001656","count":3}]},{"hash":"2151300635861840136","title":"Endocrine Signaling and Proliferation Control","description":"The cluster prominently features GO terms for insulin receptor signaling and growth hormone receptor signaling, along with negative regulation of cell population proliferation, pointing to a core theme of endocrine signaling linked to controlling cell growth. Additional terms for transcription, lens development, and stress responses suggest broader regulation of gene expression and genome maintenance under stress, but the endocrine-growth signaling axis appears central. ","confidence":"Medium","size":22,"edges":23,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035372","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0008285","count":6},{"id":"GO:0046626","count":6},{"id":"GO:0002088","count":6}]},{"hash":"1611551178351446474","title":"Immune cell differentiation and regulation","description":"The top GO terms cluster around immune cell development and regulation, including memory T cell differentiation, dendritic cell differentiation, and germinal center formation, along with control of neutrophil degranulation and broader immune signaling. Ubiquitin-related processes and transcriptional regulation support the regulatory aspect, even though a circadian rhythm term appears, the dominant signal is immune differentiation and regulatory pathways.","confidence":"High","size":22,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0043314","count":3},{"id":"GO:0043380","count":3}]},{"hash":"1541545547463493199","title":"Neural development and axon guidance","description":"The Top Terms point to CNS-focused processes: synapse assembly, axonogenesis of CNS projection neurons, corpus callosum development, and myelination, with involvement of Robo signaling and interneuron migration. While a couple of terms touch on immunity, the dominant signal is neural development and axon guidance, suggesting this cluster comprises proteins coordinating neuronal connectivity and maturation.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0019221","count":4},{"id":"GO:0021836","count":4}]},{"hash":"443174850194887944","title":"ER Redox Homeostasis and Protein Folding","description":"The cluster shows strong enrichment for redox-related processes (cell redox homeostasis, cellular oxidant detoxification, protein deglutathionylation) together with ER-associated protein folding and modification (protein folding in endoplasmic reticulum, proline hydroxylation). This combination suggests a module coordinating redox balance with maturation of proteins in the ER, including post-translational modifications, rather than a single isolated pathway.","confidence":"High","size":22,"edges":63,"triangles":63,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":15},{"id":"GO:0055114","count":8},{"id":"GO:0098869","count":8},{"id":"GO:0033158","count":7},{"id":"GO:1903026","count":7}]},{"hash":"345891408091558362","title":"Mitochondrial energy production and biogenesis","description":"The dominant GO terms point to mitochondrial function: protein import into the mitochondrial matrix, assembly of respiratory chain complex IV, and proton motive force\u2013driven ATP synthesis, all hallmarks of mitochondrial energy production and biogenesis. Some development-related terms appear but are secondary to the clear mitochondrial metabolism signal, supporting this label.","confidence":"High","size":22,"edges":168,"triangles":641,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0030150","count":3}]},{"hash":"1831570369633064901","title":"Embryonic craniofacial, neural, and heart morphogenesis","description":"This cluster centers on embryonic development and morphogenesis across multiple tissues\u2014craniofacial skeleton, palate, various cranial nerves, inner ear, limbs, and heart outflow tract\u2014indicating a cohesive theme of morphogenetic processes during early development.","confidence":"High","size":22,"edges":54,"triangles":40,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":11},{"id":"GO:0060021","count":11},{"id":"GO:0008584","count":11},{"id":"GO:0035115","count":10},{"id":"GO:0021623","count":10}]},{"hash":"557558295333081581","title":"Immune signaling and growth regulation","description":"The cluster centers on regulatory signaling pathways that modulate immune responses and cell growth (negative regulation of inflammatory response, negative regulation of T cell activation, ERK/MAPK, PI3K/AKT, TOR signaling) along with transcriptional control; a couple of development-related terms (Leydig cell differentiation, mammary gland alveolus development) suggest broader developmental regulation. Overall, the dominant theme is immune signaling and growth regulation.","confidence":"Medium","size":22,"edges":71,"triangles":96,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050728","count":3},{"id":"GO:0045737","count":3},{"id":"GO:0033327","count":3},{"id":"GO:0060749","count":3},{"id":"GO:0006351","count":3}]},{"hash":"864381438310161100","title":"Neuronal vesicle cycling and nigral development","description":"Top GO terms center on synaptic vesicle endocytosis/exocytosis, excitatory postsynaptic potential, calcium signaling, and substantia nigra development, pointing to neuronal synaptic transmission in dopaminergic nigral neurons. Broader terms like xenobiotic response and angiogenesis are less central. Thus this cluster aligns best with neuronal vesicle cycling and nigral development.","confidence":"Medium","size":22,"edges":107,"triangles":397,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":18},{"id":"GO:0060079","count":18},{"id":"GO:1900242","count":17},{"id":"GO:2000300","count":17},{"id":"GO:0021762","count":17}]},{"hash":"1668087196228447537","title":"Diverse catabolic metabolism and detoxification","description":"The top GO terms show multiple catabolic processes across diverse substrates (triglycerides, uracil, 3-phenylpropionate, 1,2-dichloroethane, poly-hydroxybutyrate) plus cellular oxidant detoxification and response to toxic substances, along with regulation of endocannabinoid signaling. This suggests a cluster of proteins involved in broad metabolite breakdown and detoxification, with some lipid-signaling context via the endocannabinoid pathway.","confidence":"Medium","size":22,"edges":102,"triangles":226,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":12},{"id":"GO:2000124","count":9},{"id":"GO:0006212","count":9},{"id":"GO:0042619","count":9},{"id":"GO:0009086","count":9}]},{"hash":"330565692565252801","title":"Transmembrane Nutrient and Ion Transporters","description":"Most of the top GO terms describe transport across membranes for small molecules and ions (glucose, pantothenate, biotin, myo-inositol, sodium ions, nitrite, nitrate). This pattern points to a cluster of membrane transporter proteins responsible for uptake/export of nutrients and ions. A few annotations (like acetylcholine biosynthesis and thermosensory behavior) may reflect broader cellular contexts but do not override the transport theme.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":6},{"id":"GO:0015887","count":6},{"id":"GO:0015878","count":6},{"id":"GO:0015798","count":6},{"id":"GO:0071436","count":6}]},{"hash":"1870128905640796397","title":"B Vitamin Cofactor Biosynthesis and Stress Response","description":"These top GO terms show two themes: biosynthesis of B vitamins and cofactors (thiamine and tetrahydrofolate) and a set of environmental response processes (to ethanol, fungicide, LPS, and cAMP signaling). The cluster likely groups proteins involved in cofactor metabolism together with proteins that respond to environmental cues, suggesting a role in basic metabolism tied to stress adaptation. ","confidence":"Medium","size":22,"edges":34,"triangles":33,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0009228","count":12},{"id":"GO:0042135","count":10},{"id":"GO:0046653","count":10},{"id":"GO:0060992","count":9},{"id":"GO:0055114","count":9}]},{"hash":"918614095238989920","title":"Embryonic organogenesis","description":"Several top GO terms center on morphogenesis and embryonic development across multiple tissues (eye, heart, lung, ovary, prostate) and in utero development, indicating the proteins act in broad organogenesis programs rather than a single tissue. The diverse but development-focused terms suggest a cohesive embryonic morphogenesis cluster.","confidence":"High","size":22,"edges":174,"triangles":825,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":12},{"id":"GO:0006366","count":11},{"id":"GO:0043010","count":9},{"id":"GO:0060441","count":9},{"id":"GO:0060528","count":8}]},{"hash":"1092634512752678512","title":"Chromatin Remodeling in Embryonic Development","description":"This cluster centers on chromatin remodeling and epigenetic regulation (chromatin remodeling, epigenetic programming, histone methylation) alongside diverse embryonic development and patterning processes (left/right patterning, endocardial cushion EMT, placenta development, cartilage morphogenesis, trophoblast differentiation, pancreatic development), suggesting proteins that coordinate epigenetic control with tissue differentiation during embryogenesis.","confidence":"High","size":22,"edges":16,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":4},{"id":"GO:0060972","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060806","count":3}]},{"hash":"1767562530733004424","title":"Lipid clearance and fibrinolytic signaling","description":"This cluster is dominated by GO terms tied to lipid processing and plasma clearance (positive regulation of lipoprotein lipase activity, positive regulation of chylomicron remnant clearance) as well as fibrinolysis (fibrinolysis, urokinase plasminogen activator signaling pathway, response to heparin) and related transport processes (transcytosis). While other terms like cholinergic synaptic transmission and locomotory behavior appear, the strongest signal ties to lipid metabolism and the fibrinolytic/coagulation axis, suggesting proteins involved in lipid clearance and fibrinolytic signaling as a cohesive theme.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0051006","count":8},{"id":"GO:0042730","count":7},{"id":"GO:0071503","count":6},{"id":"GO:0043388","count":6},{"id":"GO:2001243","count":6}]},{"hash":"335668527021252052","title":"Neural crest migration and axon guidance","description":"The top GO terms are dominated by neural crest migration and axon guidance processes (ventral trunk neural crest migration, semaphorin-plexin signaling in axon guidance, sympathetic and branchiomotor neuron projection guidance, axonal fasciculation, trigeminal nerve organization) with related synapse assembly and cell adhesion terms. A secondary signal for endothelial morphogenesis appears but the core theme centers on neural development and axon guidance.","confidence":"High","size":22,"edges":4,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0036486","count":14},{"id":"GO:1902287","count":14},{"id":"GO:0097491","count":14},{"id":"GO:0021785","count":14},{"id":"GO:0007413","count":14}]},{"hash":"1416277881438445973","title":"Innate Immune Activation and NF-\u03baB Signaling","description":"The proteins cluster around innate immune processes and NF-\u03baB pathway regulation, with strong signals for positive regulation of canonical NF-\u03baB signaling, innate immune response, neutrophil chemotaxis, dendritic cell differentiation, and mast cell degranulation. Additional terms for xenobiotic stimulus response and cell adhesion point to inflammatory signaling and immune cell recruitment, while semaphorin-plexin signaling suggests associated cell-movement guidance relevant to immune cell trafficking. Overall, the theme is innate immune activation tied to NF-\u03baB\u2013driven inflammation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0043123","count":9},{"id":"GO:0051092","count":9},{"id":"GO:0042493","count":8},{"id":"GO:0043303","count":8},{"id":"GO:0045087","count":8}]},{"hash":"476511127009639970","title":"Clathrin-mediated endocytosis and vesicle trafficking","description":"The cluster is enriched for clathrin coat assembly and both positive and negative regulation of receptor-mediated endocytosis, along with vesicle cargo loading and actin remodeling via Arp2/3, indicating a core endocytic/vesicular trafficking theme. While terms like apoptotic process and gastric secretion regulation appear, the dominant signal points to clathrin-mediated endocytosis and vesicle handling.","confidence":"High","size":22,"edges":46,"triangles":23,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0048268","count":5},{"id":"GO:0048261","count":4},{"id":"GO:0048260","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0001878","count":4}]},{"hash":"1113260064012061925","title":"Dopaminergic Neuronal Signaling and Development","description":"This cluster centers on nervous system processes, with strong representation of dopaminergic synaptic transmission, neuropeptide signaling, and nervous-system development (enteric NS, grooming behavior, pain perception). Some terms like saliva secretion and metanephric glomerulus development are less tied to neurons, but the dominant signals point to neuronal communication and development as the defining theme.","confidence":"High","size":22,"edges":173,"triangles":661,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":22},{"id":"GO:0072224","count":22},{"id":"GO:0060160","count":22},{"id":"GO:0048484","count":22},{"id":"GO:2000458","count":22}]},{"hash":"1848505380246536131","title":"Dopaminergic signaling and nervous system development","description":"The top GO terms cluster strongly around neural function and development, including dopaminergic synaptic transmission, neuropeptide signaling, grooming behavior, sensory perception of pain, and enteric nervous system development, with additional related processes like astrocyte chemotaxis regulation. This points to a cohesive module focused on dopamine-related signaling and nervous system maturation, even though a few terms (saliva secretion, kidney development, DN2 thymocyte differentiation) are less central, they do not dominate the profile.","confidence":"High","size":22,"edges":216,"triangles":1278,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":19},{"id":"GO:0072224","count":19},{"id":"GO:0060160","count":19},{"id":"GO:0048484","count":19},{"id":"GO:2000458","count":19}]},{"hash":"996555910289467029","title":"Rab/Rap GTPase-driven endosomal transport","description":"The cluster is enriched for Rap and Rab GTPase signaling terms and transport processes involving endosomes and the Golgi (plasma membrane to endosome transport, late endosome to Golgi transport, intracellular protein transport, and activation of GTPase activity), suggesting a cohesive theme of small GTPase\u2013regulated vesicular trafficking. Peripheral terms like lens morphogenesis and NMDA receptor regulation do not outweigh the central trafficking signal, supporting this label. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0032486","count":5},{"id":"GO:0090630","count":5},{"id":"GO:0032483","count":5},{"id":"GO:0046726","count":4},{"id":"GO:0070309","count":4}]},{"hash":"1814196600160909854","title":"Mitochondrial Redox and Energy Metabolism","description":"The cluster is characterized by strong representation of redox-related terms (cell redox homeostasis; oxidation-reduction process) and mitochondrial energy metabolism (mitochondrial electron transport, regulation of membrane potential). Additional links to amino acid and vitamin biosynthesis (L-glutamate, beta-alanine, thiamine) point to coordinated mitochondrial metabolic activity supporting energy production. Taken together, the terms suggest a mitochondrially focused metabolic/redox module rather than a single signaling pathway.","confidence":"High","size":22,"edges":81,"triangles":187,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":19},{"id":"GO:0045454","count":19},{"id":"GO:0043046","count":18},{"id":"GO:0042391","count":18},{"id":"GO:0097054","count":18}]},{"hash":"1645022834765068584","title":"Developmental and Immune Signaling","description":"This cluster shows enrichment across both developmental and immune-related processes: left/right pattern formation, cell migration, and locomotory behavior point to developmental signaling; and dendritic cell differentiation, memory T cell differentiation, and tyrosine phosphorylation/STAT regulation point to immune signaling; together with GPCR/PKC signaling and inositol biosynthesis, it reflects signaling pathways coordinating development and immune cell dynamics.","confidence":"Medium","size":22,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008344","count":3},{"id":"GO:0042518","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0007205","count":3}]},{"hash":"202802905137490593","title":"Nuclear gene expression and RNA processing","description":"The top GO terms cluster around transcription-related activities (DNA-templated transcription, negative regulation of transcription by RNA Polymerase II, DNA transposition) and RNA maturation/modification (7-methylguanosine cap, tRNA methylation) as well as nuclear export of the ribosomal small subunit, all pointing to nuclear gene expression regulation and RNA processing. A few terms like chlorophyll biosynthesis, sterol biosynthesis, and endothelial proliferation are less central but do not contradict the dominant theme. Overall, the cluster seems best described by a nuclear gene expression/RNA processing theme, with moderate confidence.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001935","count":5},{"id":"GO:0006313","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0036068","count":2}]},{"hash":"1058584812921826733","title":"Neural development and synapse assembly","description":"The cluster is dominated by GO terms for nervous system and brain development, along with positive regulation of synapse assembly, presynaptic active zone assembly, and cadherin-mediated cell adhesion, all pointing to neural connectivity and synaptogenesis. A minority of terms relate to bone maturation or endothelial barrier formation, which are less central to the primary neural theme but may reflect shared adhesion or blood-brain barrier context. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0043931","count":7},{"id":"GO:0007157","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0044331","count":6}]},{"hash":"782512222860378568","title":"Inflammation-linked lipid signaling and stress response","description":"The top GO terms cluster around inflammatory cues (response to lipopolysaccharide, nitrosative stress) and lipid-derived signaling/metabolism (prostaglandin metabolism, fatty acid omega-oxidation), with supporting signals related to vascular regulation and extracellular control of signaling. This suggests a cohesive theme of inflammation-associated lipid signaling and stress responses, despite some loosely related terms.","confidence":"Medium","size":22,"edges":19,"triangles":17,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0032496","count":6},{"id":"GO:0006069","count":6},{"id":"GO:0019518","count":6},{"id":"GO:0010430","count":6},{"id":"GO:0045777","count":6}]},{"hash":"1355245431214315943","title":"Osteoclastogenesis and bone resorption signaling","description":"This cluster centers on GO terms related to bone remodeling: positive regulation of bone resorption, osteoclast development, and osteoblast differentiation. There is also enrichment for proton transport and pH reduction, consistent with osteoclast-mediated acidification of the resorption lacuna, and ERK1/ERK2 cascade regulation and exocytosis, which are known players in osteoclast/osteoblast signaling and vesicle trafficking. Some retina/eye terms appear as secondary links via shared vesicle/exocytosis pathways, but the dominant theme is bone remodeling through osteoclast activity.","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045780","count":3},{"id":"GO:0070374","count":2},{"id":"GO:0015991","count":2},{"id":"GO:0008057","count":2},{"id":"GO:0045921","count":2}]},{"hash":"2137841531381342205","title":"Embryonic patterning and tissue morphogenesis","description":"The top GO terms cluster around developmental patterning (left/right pattern formation) and broad tissue morphogenesis across multiple embryonic lineages\u2014endocrine system development, heart cushion EMT, placenta-related differentiation, cartilage morphogenesis, pancreatic development, and palate formation\u2014indicating a cohesive theme of embryonic patterning and organ/tissue morphogenesis. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":20},{"id":"GO:0035270","count":20},{"id":"GO:0003198","count":20},{"id":"GO:0060806","count":20},{"id":"GO:0060536","count":20}]},{"hash":"512689277501037390","title":"Embryonic Development and Morphogenesis","description":"The Top Terms predominantly describe embryogenesis and formation of tissues and organs, including left-right patterning, placental and mesoderm development, cartilage and hair follicle morphogenesis, and epithelial-to-mesenchymal transitions involved in heart and palate formation. This cohesive set indicates a cluster of proteins involved in early developmental patterning and morphogenesis.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":20},{"id":"GO:0035270","count":20},{"id":"GO:0060806","count":20},{"id":"GO:0060536","count":20},{"id":"GO:0060707","count":20}]},{"hash":"966468543010001482","title":"Cardiac GPCR signaling and contraction regulation","description":"This label captures the strongest signals: tachykinin receptor signaling, GPCR desensitization and internalization, and negative regulation of heart/striated muscle contraction, along with heart development. A few terms (spindle organization, zygote asymmetric cell division) seem less connected, but do not overwhelm the GPCR-heart theme.","confidence":"Medium","size":22,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007051","count":4},{"id":"GO:0043407","count":4},{"id":"GO:0010070","count":4},{"id":"GO:0031914","count":4},{"id":"GO:0007507","count":3}]},{"hash":"508153786193654310","title":"Dopaminergic Neuropeptide Signaling in Nervous System","description":"The cluster is rich in terms related to dopamine signaling (synaptic transmission, dopaminergic; regulation of dopamine receptor signaling) and neuropeptide signaling, with related nervous system development and behaviors (grooming, pain perception, enteric nervous system development). These collectively point to a cohesive dopamine/neuropeptide\u2013driven neural signaling module, despite a couple non-neural annotations that may reflect broad GO mappings.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":22},{"id":"GO:0072224","count":22},{"id":"GO:0060160","count":22},{"id":"GO:0048484","count":22},{"id":"GO:2000458","count":22}]},{"hash":"3694878435197797","title":"Mitochondrial regulation of neuronal signaling","description":"The top GO terms cluster around mitochondrial functions\u2014positive regulation of mitochondrial DNA replication, inner mitochondrial membrane organization, and mitochondrial membrane potential\u2014paired with dopaminergic synaptic transmission regulation. This suggests the proteins collectively influence mitochondrial dynamics to modulate neuronal signaling. Cadherin-mediated adhesion and protease regulation appear supportive but secondary to the mitochondrial\u2013synaptic theme.","confidence":"High","size":21,"edges":183,"triangles":994,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:2000049","count":8},{"id":"GO:1901585","count":8},{"id":"GO:0090297","count":8},{"id":"GO:0032226","count":8},{"id":"GO:0001302","count":8}]},{"hash":"1128108590212906959","title":"Neural crest migration and axon guidance","description":"Based on the top GO terms, the proteins cluster around neural development processes: neural crest cell migration (ventral trunk neural crest cell migration) and multiple axon guidance cues (semaphorin-plexin signaling pathway involved in axon guidance, sympathetic neuron projection guidance, branchiomotor neuron axon guidance, trigeminal nerve structural organization, axonal fasciculation). The presence of heterophilic cell\u2013cell adhesion also supports tissue organization essential for neural development. Together, these terms point to a cohesive function in neural crest migration and axon pathfinding.","confidence":"High","size":21,"edges":62,"triangles":38,"max_degree":11,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0014068","count":12},{"id":"GO:0007157","count":11},{"id":"GO:0036486","count":11},{"id":"GO:1902287","count":11},{"id":"GO:0097491","count":11}]},{"hash":"1110104551793661689","title":"Inflammation-driven bone remodeling and angiogenesis","description":"This cluster centers on inflammatory signaling (interleukin-1 response) paired with regulation of osteoblast proliferation, collagen fibril organization, and promotion of angiogenesis, pointing to coordinated bone/ECM remodeling and vascular growth during tissue repair. Immune-related terms (recognition of apoptotic cells, complement activation) align with inflammation and remodeling, while xenobiotic response and brown fat differentiation suggest broader metabolic remodeling accompanying tissue remodeling. Overall, the terms converge on connective tissue remodeling with immune and vascular involvement.","confidence":"Medium","size":21,"edges":155,"triangles":603,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071347","count":7},{"id":"GO:0033689","count":6},{"id":"GO:0045766","count":6},{"id":"GO:1902042","count":6},{"id":"GO:0030199","count":6}]},{"hash":"1268224064564193422","title":"Notch Signaling and Amino Acid Catabolism","description":"Notch signaling pathway is the most represented term (GO:0007219, 15 proteins), but the cluster also shows several amino acid catabolic and biosynthetic processes (e.g., L-kynurenine, L-alanine, L-aspartate catabolic; biotin and protoporphyrinogen IX biosynthesis). This suggests proteins with Notch-related regulatory roles that also associate with metabolic contexts, or a set of multifunctional proteins annotated across signaling and metabolism. Confidence: Medium","confidence":"","size":21,"edges":171,"triangles":969,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007219","count":15},{"id":"GO:0097053","count":14},{"id":"GO:0042853","count":14},{"id":"GO:0019878","count":12},{"id":"GO:0006782","count":12}]},{"hash":"1391820906005221182","title":"Melanocyte trafficking and skin/hair growth","description":"The dominant GO terms point to pigment cell biology and skin/hair biology: endosome to melanosome transport and hair follicle cell proliferation directly relate to melanocytes and hair follicle dynamics. Wound healing reflects skin regeneration, and neuroblast proliferation hints at neural crest\u2013derived pigment cells. GPCR signaling and autophagy regulation appear as supporting general cellular processes in these tissues. Overall, this cluster most coherently maps to melanocyte-related trafficking and skin/hair growth processes, with some broader signaling terms accompanying it.","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902692","count":21},{"id":"GO:0044319","count":21},{"id":"GO:0034379","count":21},{"id":"GO:0033028","count":21},{"id":"GO:0035646","count":21}]},{"hash":"685514786812737163","title":"DNA Damage Response and Apoptosis Regulation","description":"This cluster is enriched for GO terms related to sensing DNA damage, promoting DNA repair, and regulating apoptosis (intrinsic and extrinsic), including cellular responses to UV; additional terms involving calcium and sodium ion transport suggest signaling cross-talk but the dominant theme is genome integrity maintenance and programmed cell death control.","confidence":"Medium","size":21,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002028","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0032526","count":1},{"id":"GO:1902230","count":1}]},{"hash":"549531731291845894","title":"DNA Replication & Repair Machinery","description":"The cluster shows strong signals for DNA replication and multiple DNA repair pathways (including double-strand break repair via homologous recombination and interstrand cross-link repair), plus cellular responses to replication stress from agents like hydroxyurea and cisplatin. The frequent protein homooligomerization term suggests assembly of multi-subunit replication/repair complexes, consistent with a cohesive module coordinating replication fork progression and DNA damage repair.","confidence":"High","size":21,"edges":203,"triangles":1208,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051260","count":9},{"id":"GO:0006260","count":7},{"id":"GO:0006351","count":6},{"id":"GO:1990918","count":6},{"id":"GO:0036297","count":6}]},{"hash":"2214094050759505817","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms related to protein synthesis and ribosome assembly, including cytoplasmic and mitochondrial translation, ribosomal large subunit assembly, SSU-rRNA maturation, and general ribosome biogenesis. This suggests proteins here function together in ribosome production and the translation machinery, with a smaller subset aligning to stress or signaling responses. Overall, a coherent theme around ribosome assembly and translation.","confidence":"High","size":21,"edges":167,"triangles":732,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":18},{"id":"GO:0046677","count":3},{"id":"GO:0000027","count":3},{"id":"GO:0000462","count":3},{"id":"GO:1990090","count":2}]},{"hash":"80787027018399732","title":"Neuroimmune-Wnt signaling cluster","description":"This set is enriched for neural-development terms like axonogenesis and myelination, plus immune-related terms (defense response to virus, innate immune response) and Wnt pathway involvement (Wnt signalosome assembly). Together these suggest a module where neural development intersects with immune signaling and Wnt signaling, justifying the label. ","confidence":"Medium","size":21,"edges":166,"triangles":685,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007409","count":7},{"id":"GO:0006469","count":7},{"id":"GO:0051607","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0045842","count":7}]},{"hash":"102236155138916596","title":"Proteostasis and mitochondrial quality control","description":"The cluster centers on ubiquitin-related proteostasis: sumoylation, deubiquitination, ERAD, and aggresome formation, with linked mitochondrial quality control through mitophagy and regulation of mitochondrial fusion; together these terms point to a cohesive module maintaining protein and mitochondrial health via degradation and autophagy.","confidence":"High","size":21,"edges":188,"triangles":1045,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":16},{"id":"GO:1904378","count":9},{"id":"GO:0045648","count":9},{"id":"GO:0030433","count":9},{"id":"GO:0097237","count":8}]},{"hash":"837126027399323459","title":"Ion transport and ionic homeostasis","description":"The cluster\u2019s top GO terms center on transmembrane ion movement and maintenance of ion balance, including sodium, potassium, calcium (ER Ca2+), and copper transport, as well as related regulatory processes. This points to a cohesive theme of ion transport and homeostasis across membranes, with downstream links to calcium signaling and mineralization processes like otolith formation. Therefore, a concise label capturing these shared functions is \u201cIon transport and ionic homeostasis.\u201d","confidence":"High","size":21,"edges":143,"triangles":540,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0045822","count":19},{"id":"GO:0097623","count":19},{"id":"GO:0002028","count":19},{"id":"GO:1905122","count":19},{"id":"GO:1903416","count":19}]},{"hash":"1373348169780683510","title":"Oxidative stress and innate immune signaling with ubiquitin turnover","description":"Based on the top GO terms, the cluster centers on cellular responses to oxidative stress (hydrogen peroxide) and to bacterial components (lipopolysaccharide, muramyl dipeptide), indicating redox and innate immune signaling. The presence of ubiquitination-related processes (protein ubiquitination, ERAD, MVB sorting) and peroxisome matrix protein import suggests a strong link to protein quality control under stress. A vasculogenesis term is present but does not dominate, so the overall theme is oxidative/immune stress coupled with ubiquitin-mediated turnover.","confidence":"Medium","size":21,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0003257","count":3},{"id":"GO:0001570","count":3},{"id":"GO:0032495","count":3}]},{"hash":"1725618740730184303","title":"Pigmentation and Melanosome Assembly","description":"Based on the Top Terms, pigmentation (GO:0043473) and melanosome assembly (GO:1903232) are explicitly represented, suggesting the cluster's proteins function in pigment synthesis/transport and melanosome biogenesis. Additional enrichment in vesicle trafficking from the ER to the Golgi (GO:0006888) and regulation of GTPase activity (GO:0043547) supports a theme of organelle transport and localization related to pigment-containing organelles. Other terms such as cuticle development and stress or apoptotic responses may reflect broader cellular roles but are less central. Overall, the cluster appears to center on pigment-related processes, especially melanosome assembly, with some related trafficking activity.","confidence":"Medium","size":21,"edges":156,"triangles":604,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0043473","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0006388","count":2},{"id":"GO:0043248","count":2}]},{"hash":"1068601320640495543","title":"Neuronal development and axon guidance","description":"The top GO terms emphasize nervous system development, neuron cell\u2013cell adhesion, and axon guidance (including dopaminergic and serotonergic pathways), indicating a coherent theme of neuronal connectivity, with a few non-neuronal terms likely incidental.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043931","count":9},{"id":"GO:0051965","count":9},{"id":"GO:0007156","count":8},{"id":"GO:0007157","count":8},{"id":"GO:0007399","count":8}]},{"hash":"1999336931323211084","title":"LPS-Triggered MAPK Signaling in Macrophages","description":"The top terms converge on a lipopolysaccharide response with activation of MAPK pathways (ERK, JNK), plus macrophage chemotaxis and cell-matrix adhesion, indicating a cohesive module of LPS-responsive signaling and macrophage behavior.","confidence":"High","size":21,"edges":85,"triangles":288,"max_degree":12,"top_function":"wound healing","top_go_terms":[{"id":"GO:0071222","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0014068","count":16},{"id":"GO:0031663","count":16},{"id":"GO:0090314","count":15}]},{"hash":"5521821977065825","title":"Nuclear import and pore complex assembly","description":"This cluster is dominated by GO terms for import of ribosomal and other proteins into the nucleus and for assembly of the nuclear pore complex, indicating a cohesive function in nucleocytoplasmic transport and NPC formation. While a few terms touch on other nuclear processes, the strongest signal is the nuclear import/NPC assembly theme.","confidence":"High","size":21,"edges":171,"triangles":952,"max_degree":19,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006610","count":5},{"id":"GO:0006607","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0051292","count":5},{"id":"GO:0000060","count":5}]},{"hash":"335476412749696754","title":"Cardiac muscle contraction and sarcomere organization","description":"The top GO terms are dominated by sarcomere-related processes and cardiac muscle function (sarcomere organization, positive regulation of sarcomere organization, cardiac muscle contraction) with signals of heart-rate regulation by epinephrine and vascular smooth muscle behavior, indicating a core cluster of heart muscle machinery and its regulation. A few terms related to nervous system development and vision appear but are secondary to the strong muscle-contraction theme. Spicule insertion is noted but does not override the central cardiac/sarcomere connectivity; overall this cluster aligns best with heart muscle contraction and sarcomere organization.","confidence":"High","size":21,"edges":208,"triangles":1293,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0034609","count":20},{"id":"GO:0045214","count":20},{"id":"GO:0060298","count":20},{"id":"GO:0060048","count":20},{"id":"GO:0003065","count":20}]},{"hash":"1384014301855878908","title":"Small GTPase\u2013driven actin remodeling and cell migration","description":"It centers on actin cytoskeleton organization and small GTPase signaling (Rho/Ras), with lamellipodium and filopodium assembly and cell migration as core themes, suggesting coordinated cytoskeletal remodeling driving motility; insulin signaling may reflect cross-talk with cytoskeletal regulation.","confidence":"High","size":21,"edges":131,"triangles":419,"max_degree":20,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":15},{"id":"GO:0030036","count":11},{"id":"GO:0007264","count":11},{"id":"GO:0060313","count":11},{"id":"GO:0043314","count":11}]},{"hash":"669747197590291167","title":"Autophagy and Membrane Trafficking","description":"The cluster is dominated by macroautophagy with additional connections to membrane remodeling, endocytosis regulation, and cytoskeletal organization (actin filaments), plus Golgi-related protein retention. This points to a cohesive theme of autophagy-linked membrane dynamics and trafficking driven by cytoskeletal changes.","confidence":"High","size":21,"edges":27,"triangles":8,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0016236","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0097320","count":6},{"id":"GO:0000747","count":6},{"id":"GO:0060990","count":6}]},{"hash":"457751527273046618","title":"Neuronal signaling and endosomal trafficking","description":"This cluster centers on neural development and signaling pathways (negative regulation of axonogenesis, regulation of neuroblast proliferation, GPCR signaling, Rab protein signaling) and includes intracellular trafficking (endosome to melanosome transport) and autophagy regulation, suggesting a cohesive theme of neuronal signaling coupled with vesicle trafficking. While some terms touch on broader processes like wound healing and immune apoptosis, the dominant pattern is neural signaling alongside endosomal transport. ","confidence":"Medium","size":21,"edges":199,"triangles":1154,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":21},{"id":"GO:0032482","count":21},{"id":"GO:1902692","count":19},{"id":"GO:0044319","count":19},{"id":"GO:0034379","count":19}]},{"hash":"79527530230135251","title":"Vascular and cardiac development","description":"Most enriched GO terms center on blood vessel and heart development (sprouting angiogenesis; endocardial cushion morphogenesis; regulation of BMP signaling; cardioblast differentiation; cardiac hypertrophy response). Additional terms point to broader organogenesis (organ induction; enteric nervous system and ureteric bud development) and tissue repair (wound healing). Together these indicate proteins involved in cardiovascular vascular formation and cardiac morphogenesis, with supportive roles in general organ development.","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"wound healing","top_go_terms":[{"id":"GO:0002043","count":19},{"id":"GO:0001657","count":19},{"id":"GO:0030513","count":19},{"id":"GO:0048484","count":16},{"id":"GO:1903242","count":16}]},{"hash":"2237169955418220368","title":"NF-kB-driven immune signaling","description":"This cluster centers on NF-kB pathway activity (canonical and non-canonical), TNF-mediated signaling, and immune cell functions (innate and T cell proliferation), with links to spleen development. The presence of translation and ubiquitination terms fits regulatory steps in immune signaling. Together, these terms point to a cohesive role in NF-kB\u2013mediated immune activation.","confidence":"High","size":21,"edges":105,"triangles":234,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043123","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0006412","count":5},{"id":"GO:0016567","count":4},{"id":"GO:0071260","count":4}]},{"hash":"1985034389962793955","title":"Glutamatergic signaling and ion transport","description":"The set is dominated by neural-focused themes: phospholipase C-activating GPCR glutamate receptor signaling, sodium and calcium ion transport, calcium import regulation, responses to electrical stimuli, and light-perception cues, all pointing to glutamatergic neuronal signaling and ion handling. An energy component (electron transport chain) aligns with the metabolic needs of active neurons, while a few terms like oocyte maturation and fungicide response appear as noise. Overall, the cluster centers on neuronal communication and sensory processing via glutamate signaling and ion flux.","confidence":"Medium","size":21,"edges":151,"triangles":555,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":21},{"id":"GO:0035725","count":21},{"id":"GO:0030818","count":21},{"id":"GO:0060992","count":21},{"id":"GO:0090280","count":21}]},{"hash":"1916277680813186976","title":"Spermatogenesis and piRNA Chromatin Remodeling","description":"The cluster is dominated by GO terms tied to male germline development, including piRNA processing, male meiotic nuclear division, spermatid nucleus differentiation, and DNA methylation in gamete generation, as well as chromatin remodeling and transcriptional regulation. Together these suggest a cohesive germline program involving meiosis, transposon silencing via piRNA pathways, and dynamic chromatin remodeling during spermatogenesis. Some immune-related terms appear but are secondary to the core germline-focused theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0034587","count":6},{"id":"GO:0007140","count":6},{"id":"GO:0043046","count":6},{"id":"GO:0043044","count":5}]},{"hash":"1209823714249967266","title":"Unknown","description":"The GO terms span inflammation regulation, cytoskeletal dynamics, protein ubiquitination/degradation, RNA processing, and developmental patterning, with no single dominant function linking the proteins. Because no cohesive theme emerges across the cluster, a specific, representative label cannot be assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904468","count":3},{"id":"GO:0043087","count":3},{"id":"GO:0046785","count":3},{"id":"GO:0051299","count":3},{"id":"GO:0031987","count":3}]},{"hash":"1815184767447963457","title":"Immune Activation and Antigen Presentation","description":"This cluster is enriched for both innate and adaptive immune functions, including phagocytosis, complement activation, and innate immune response, alongside B cell activation and BCR signaling. It also covers antigen processing and presentation via MHC I and II pathways, regulation of antigen presentation, and antibacterial humoral responses with IL-17 production, illustrating a cohesive theme of immune activation and antigen presentation across innate and adaptive arms.","confidence":"High","size":21,"edges":151,"triangles":598,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":21},{"id":"GO:0006958","count":21},{"id":"GO:0045087","count":21},{"id":"GO:0050871","count":21},{"id":"GO:0050853","count":21}]},{"hash":"452819757977067125","title":"Neural development and inflammatory signaling","description":"This cluster is dominated by GO terms for central nervous system development and neural connectivity (axon guidance, corpus callosum development, synapse assembly) along with inflammatory/immune signaling (inflammatory response, interleukin-18 production), suggesting proteins that coordinate neural development with immune mediators. While there are some general developmental terms (bone/tooth, organogenesis), the core theme centers on neural patterning and immune-related regulation.","confidence":"High","size":21,"edges":196,"triangles":1095,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032741","count":21},{"id":"GO:0072224","count":21},{"id":"GO:0021972","count":21},{"id":"GO:0006954","count":21},{"id":"GO:0061368","count":21}]},{"hash":"1309354552835272575","title":"Neural development and brain formation","description":"The cluster is enriched for neural-development related GO terms (forebrain development, neural tube closure, cerebral cortex development, multicellular organism development) and DNA-templated transcription, suggesting transcriptional regulation guiding neurodevelopment. The presence of cell cycle and ER stress\u2013related terms may reflect proliferating neural progenitors and stress responses during development, but the dominant theme is brain development. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0030900","count":5},{"id":"GO:0000082","count":5},{"id":"GO:0071276","count":5},{"id":"GO:0001843","count":5}]},{"hash":"1144053293936610413","title":"Neuronal Morphogenesis and Synaptic Exocytosis","description":"This cluster centers on neuronal development and synaptic function: dendrite development, positive regulation of synapse structural plasticity, and exocytosis suggest processes of synaptic maturation and neurotransmitter release. Rho GTPase signaling and activation of GTPase activity indicate cytoskeletal remodeling that shapes dendritic growth, while negative regulation of SNARE complex assembly and protein ubiquitination reflect tight control of vesicle fusion and protein turnover at synapses. The inclusion of cochlea morphogenesis supports a sensory-neuron development context, tying morphogenesis to synaptic activity. High","confidence":"","size":21,"edges":49,"triangles":38,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008285","count":5},{"id":"GO:0035023","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0006887","count":3},{"id":"GO:0090103","count":3}]},{"hash":"1397592848980903140","title":"Ribosome biogenesis with immune signaling","description":"The top GO terms show a core of ribosome biogenesis and nuclear export of the large ribosomal subunit, suggesting a role in ribosome assembly. The other prominent terms are all immune or inflammatory signaling processes (NF-kappaB, JNK, interferon, TNF, activated T cell proliferation), indicating these proteins may also participate in immune activation or regulation. Together, the cluster appears to combine ribosome-related production with immune signaling roles, hence a label that captures both aspects.","confidence":"Medium","size":21,"edges":19,"triangles":0,"max_degree":5,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0030011","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0030154","count":2}]},{"hash":"809658077525500383","title":"Neural development and axon growth signaling","description":"These proteins cluster around neural development and axon growth signaling. Top GO terms emphasize nervous system development, hippocampus development, regulation of axon extension/axonogenesis, and signaling cascades (ERK/JNK) plus focal adhesion regulation, suggesting roles in neuronal differentiation and axon outgrowth; one term (beta selection) appears unrelated noise but does not dominate the set.","confidence":"High","size":21,"edges":129,"triangles":372,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043366","count":21},{"id":"GO:0046330","count":21},{"id":"GO:0007399","count":21},{"id":"GO:0043552","count":21},{"id":"GO:0070374","count":21}]},{"hash":"212077578693324269","title":"Ubiquitin-Proteasome System","description":"The top terms are dominated by ubiquitination and ubiquitin-dependent protein catabolic processes, with clear signals for protein ubiquitination and degradation. While there are additional terms related to circadian regulation, NF-kappaB-related signaling, and development, these can be linked to ubiquitin pathways that modulate diverse cellular processes. Overall, the cluster appears centered on ubiquitin-mediated protein modification and turnover.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000083","count":10},{"id":"GO:0000209","count":9},{"id":"GO:0042787","count":7},{"id":"GO:0033280","count":6},{"id":"GO:0098907","count":6}]},{"hash":"21200240245744694","title":"Transcriptional control and developmental signaling","description":"The top GO terms point to gene expression regulation (mRNA processing, transcription) alongside developmental signaling pathways (Notch, ephrin signaling) and processes like angiogenesis and synaptic plasticity regulation, suggesting a cluster of proteins that link transcriptional control with developmentally important signaling. The presence of virus-host interaction terms adds context but does not outweigh the core theme of transcriptional and signaling regulation in development. Overall, the proteins likely function together in coordinating gene expression with developmental signaling processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006397","count":4},{"id":"GO:0000289","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0044829","count":3},{"id":"GO:0045746","count":3}]},{"hash":"454948758587746117","title":"Wnt signaling regulation by ubiquitination in development","description":"The cluster is enriched for GO terms related to canonical Wnt signaling regulation (both positive and negative), ubiquitin-dependent protein catabolic processes and ubiquitination, and development-related terms (bone, ectoderm, adipose). This points to proteins that modulate Wnt pathway activity via ubiquitin-mediated proteolysis and participate in developmental processes.","confidence":"High","size":21,"edges":10,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0051260","count":2},{"id":"GO:1903077","count":2},{"id":"GO:1903364","count":2}]},{"hash":"89940360129014574","title":"Ciliary/Tubulin Assembly and Vesicle Transport","description":"The cluster includes GO terms for cilium assembly and tubulin complex assembly, plus vesicle trafficking (anterograde synaptic vesicle transport) and organelle-related processes (lysosome localization, vacuolar acidification, proton transport, and ATP synthesis). These point to a common theme of cytoskeletal/mitochondrial apparatus supporting intracellular transport and organelle homeostasis. Some terms like transcription elongation or broad wound healing are peripheral, but the strongest signal is vesicle trafficking with cytoskeletal and organelle maintenance functions.","confidence":"Medium","size":21,"edges":167,"triangles":752,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":2},{"id":"GO:0007021","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0032418","count":2}]},{"hash":"1494233296234994308","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":88,"triangles":143,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051083","count":6},{"id":"GO:0006620","count":6},{"id":"GO:0016477","count":4},{"id":"GO:0006397","count":4},{"id":"GO:2001275","count":4}]},{"hash":"1668961939296230886","title":"Neuronal mitochondrial transport","description":"Predominant GO terms point to axonal transport of mitochondria, including both anterograde and retrograde movement, indicating a cluster centered on mitochondrial trafficking in neurons. Additional terms touch on mitochondrial protein import and stress responses (hypoxia, apoptosis), suggesting a broader but mitochondria-centered neuronal function cluster.","confidence":"High","size":21,"edges":130,"triangles":329,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0019896","count":4},{"id":"GO:0008089","count":4},{"id":"GO:0097211","count":4},{"id":"GO:0008090","count":4},{"id":"GO:0071383","count":4}]},{"hash":"269881072562663827","title":"Steroid-responsive signaling and antiviral defense","description":"This cluster appears to group signaling and stress/hormone responses (ERK cascade, neuropeptide signaling, dexamethasone and estradiol stimuli) with antiviral immune activities (defense against virus, viral genome replication inhibition). The shared thread is steroid/hormone\u2013responsive signaling intersecting with immune and neuronal pathways, though some terms (ear development, angiogenesis, NAD+ metabolism) are less central.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0007218","count":3},{"id":"GO:0048839","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0051607","count":2}]},{"hash":"1268297604018976168","title":"Cardiac and skeletal muscle development with circadian regulation","description":"The cluster centers on development and morphogenesis of heart and skeletal muscle (heart development, ventricular myocardium morphogenesis, satellite cell proliferation, muscle regeneration) while also highlighting circadian regulation of gene expression, plus several embryonic organogenesis terms. This suggests a cohesive theme around muscular and cardiac development with an accompanying circadian regulatory layer.","confidence":"High","size":21,"edges":35,"triangles":30,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043433","count":10},{"id":"GO:0032922","count":10},{"id":"GO:0043415","count":7},{"id":"GO:0014842","count":7},{"id":"GO:0060528","count":6}]},{"hash":"401959307246511935","title":"Rho-Actin Signaling and Cytoskeleton Dynamics","description":"The GO terms are dominated by regulation of Rho and Ras signaling, integrin activation, filopodium assembly, acrosome reaction, thrombin receptor signaling, and synaptic vesicle priming, all of which point to actin cytoskeleton remodeling and related signal transduction governing adhesion, motility, and vesicle dynamics. While some terms like mRNA stabilization appear more peripheral, the central theme is actin-driven cytoskeletal rearrangements and associated signaling.","confidence":"Medium","size":21,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0048255","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0016082","count":2}]},{"hash":"1752194737808262641","title":"Neural development and axon guidance","description":"The cluster is dominated by terms related to nervous system development, neurogenesis, axon guidance, and synaptic assembly regulation, plus Slit-Robo signaling and myelination. Together these indicate a cohesive theme of neural differentiation, connectivity formation, and glial involvement, despite one outlier term (symbiont entry into host cell) that likely reflects annotation noise rather than a central function. Confidence: High","confidence":"","size":21,"edges":7,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":13},{"id":"GO:0051963","count":13},{"id":"GO:0022008","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0007411","count":12}]},{"hash":"319719762256185892","title":"Immune cell adhesion and activation regulation","description":"Most top GO terms converge on cell-cell adhesion and immune signaling, including heterophilic adhesion, synapse assembly, and regulation of macrophage, T cell, and NK cell activities. The presence of terms for NK and T cell regulation, IL-4 production, and immune synapse-related processes suggests a theme of immune cell communication and activation control rather than a single enzymatic function. This label captures the common function tying the cluster together.","confidence":"High","size":21,"edges":3,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":18},{"id":"GO:0090138","count":18},{"id":"GO:0086072","count":18},{"id":"GO:0043318","count":18},{"id":"GO:0051963","count":18}]},{"hash":"1572128429003397218","title":"Systemic signaling and stimulus responses","description":"This cluster spans insulin signaling, immune response to lipopolysaccharide, wound response, nervous-system\u2013related processes (startle, locomotor rhythm, visual perception), and apoptosis/tissue remodeling. The GO terms point to diverse signaling and stress responses across multiple tissues rather than a single pathway, so a label reflecting system-wide signaling and stimulus responses fits best.","confidence":"Medium","size":21,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0060044","count":3},{"id":"GO:0009611","count":3},{"id":"GO:0001964","count":3}]},{"hash":"1216022973969482928","title":"Androgen signaling and male reproductive development","description":"These proteins cluster around cell division and mitotic cell cycle terms, and also include prostate gland development, male sex differentiation, and steroid hormone receptor complex assembly terms, pointing to a shared theme of androgen signaling guiding male reproductive development and linked cell proliferation.","confidence":"Medium","size":21,"edges":128,"triangles":421,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":12},{"id":"GO:0000278","count":11},{"id":"GO:0030850","count":8},{"id":"GO:0006463","count":8},{"id":"GO:0046661","count":8}]},{"hash":"1534149405535190099","title":"Unknown","description":"The GO terms are highly diverse and span unrelated processes (spindle assembly, transcriptional regulation, fat cell differentiation, mechanosensation, pinocytosis, chloroplast protein import, chemokine production, etc.), with no clear shared function or pathway. The lack of edges and the presence of obsolete terms further suggest a non-cohesive collection rather than a single biological module. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":4},{"id":"GO:0051225","count":4},{"id":"GO:0043488","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0045444","count":3}]},{"hash":"986149826266605722","title":"Telomere maintenance and chromosome dynamics","description":"These proteins cluster around telomere-related processes (telomere maintenance via telomerase, telomere capping, telomere binding, and localization to the telomeric region) and chromosome dynamics (spindle assembly and chromatid cohesion-related), suggesting a theme of genome stability and mitotic chromosome regulation. While there are some broader signaling terms like Wnt and cell migration present, the dominant signal points to telomere/chromosome maintenance.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":5},{"id":"GO:1904743","count":5},{"id":"GO:0032212","count":5},{"id":"GO:1904908","count":5},{"id":"GO:1904355","count":5}]},{"hash":"1039875686084587674","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around processes in early development and tissue formation\u2014heart development (endocardial cushion EMT), left/right patterning, placenta/trophoblast differentiation, cartilage morphogenesis, and pancreatic cell development\u2014with supporting cellular processes like microtubule polymerization and centrosome separation relevant to developmental cell division. Together, these terms point to a cohesive theme of embryonic development and morphogenesis rather than a single specialized pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0060972","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3}]},{"hash":"1621496212080117421","title":"Developmental signaling and tissue patterning","description":"GO terms indicate developmental processes across multiple tissues (heart, brain, muscle) with signaling, cell adhesion, and tissue organization; neural and muscle terms together imply organogenesis and patterning rather than a single function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045163","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0007275","count":11},{"id":"GO:0097090","count":10},{"id":"GO:0007432","count":10}]},{"hash":"1753284168221022713","title":"Neuronal development and synapse regulation","description":"The top GO terms cluster around nervous system development, synapse assembly, dendritic spine development, and cell adhesion, suggesting a focus on neural connectivity and synaptic regulation. While there are also terms for organ development and immune processes, the dominant theme is neural development and synaptic modulation. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048671","count":8},{"id":"GO:0061000","count":8},{"id":"GO:0001822","count":8},{"id":"GO:0051965","count":6},{"id":"GO:0001501","count":6}]},{"hash":"2143169953259975077","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around developmental processes across multiple tissues\u2014left/right patterning, endocrine development, endocardial cushion EMT, cartilage morphogenesis, pancreatic cell development, and placenta-related differentiation\u2014indicating a shared role in embryogenesis and tissue formation. Transport-related terms are present but seem secondary to the overarching developmental theme, so the label emphasizes morphogenesis and differentiation during development.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060806","count":4}]},{"hash":"1590037515538235220","title":"Stress-induced cellular responses and tissue remodeling","description":"The cluster\u2019s top GO terms span diverse stress-response categories (lipopolysaccharide, hydroperoxide, UV, ethanol) along with tissue homeostasis and differentiation/regulation related to connective tissue (osteoblast differentiation; negative regulation of fibroblast/myofibroblast activity). This suggests a broad theme around cellular stress signaling impacting tissue maintenance and remodeling, rather than a single tightly connected function. However, the connections are not strong (no edges), so the association is moderate rather than definitive.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0001894","count":2},{"id":"GO:0000045","count":2},{"id":"GO:0071447","count":2},{"id":"GO:0001649","count":2}]},{"hash":"1198837342687050418","title":"Muscle and motor neuron development","description":"These terms cluster around the development and organization of muscle tissue and its innervation: skeletal muscle development and sarcomere organization point to muscle formation, while motor neuron axon guidance and ventral spinal cord interneuron specification indicate neural connectivity. Additional terms like heart development and ectoderm formation reflect broader embryonic patterning, but the prevailing theme is coordinated muscle and nervous system development. Overall, the cluster seems to reflect a shared developmental program linking muscle formation with motor neuron specification and guidance.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0045214","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0021526","count":2},{"id":"GO:0035847","count":2}]},{"hash":"1213240037751808804","title":"Embryogenesis and Patterning","description":"These proteins cluster around a theme of embryonic development and tissue morphogenesis. The top GO terms emphasize left/right pattern formation, endocrine system development, epithelial to mesenchymal transition in heart development, placental differentiation, cartilage morphogenesis, and pancreatic cell development, pointing to roles in lineage specification and organogenesis. Transcription-related terms (DNA-templated transcription and transcription regulation by RNA polymerase II) further support coordinated gene expression during development. Taken together, the cluster represents embryogenesis and patterning across multiple tissues.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":17},{"id":"GO:0035270","count":17},{"id":"GO:0003198","count":17},{"id":"GO:0060806","count":17},{"id":"GO:0060536","count":17}]},{"hash":"1148295552822250930","title":"Kidney development and ureteric bud morphogenesis","description":"The terms are dominated by kidney-related morphogenesis, especially ureteric bud branching and mesonephric duct development (e.g., ureteric bud morphogenesis, mesonephric duct development, branching involved in ureteric bud morphogenesis). Supporting terms touch on organogenesis-associated processes like vascular development and stromal/cytokine signaling, with additional general development signals such as fibroblast proliferation and stress-fiber formation. This combination points to renal organogenesis as the core theme. ","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0051496","count":8},{"id":"GO:0002062","count":8},{"id":"GO:0060716","count":8},{"id":"GO:0060675","count":7},{"id":"GO:0060907","count":7}]},{"hash":"1565683758398243923","title":"Embryonic angiogenesis and MAPK signaling","description":"Top terms center on angiogenesis and vascular remodeling (positive regulation of smooth muscle cell migration; angiogenesis) and MAPK/ERK signaling (ERK1/ERK2 cascade; positive regulation of ERK1/ERK2 cascade), with several developmental terms (thymus development, embryonic digestive tract development) suggesting an embryonic vascular/organ-development theme; a few ancillary terms like cellular response to heat may reflect broader stress-responsive roles.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014911","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0048538","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0034605","count":4}]},{"hash":"1922580646256631581","title":"Detoxification and Oxidative Metabolism","description":"The GO terms show a concentration on detoxification (response to toxic substance, cellular oxidant detoxification), oxidation-reduction processes, and the epoxygenase P450 pathway, suggesting a set of proteins involved in oxidative metabolism and xenobiotic/detox pathways. Some terms appear less related (e.g., certain catabolic or obsolete processes), but the dominant theme is detoxification and oxidative metabolism.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000124","count":2},{"id":"GO:0006212","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0009086","count":2},{"id":"GO:0019380","count":2}]},{"hash":"1401359428803982874","title":"Neurodevelopment with immune signaling","description":"This cluster is dominated by neural development signals, with terms like neurogenesis, synapse organization, and positive regulation of collateral sprouting. It also contains immune-related processes, including complement activation (classical and alternative pathways) and positive regulation of chemokine production, suggesting neural-immune interactions. Some terms such as response to xenobiotic stimulus and maintenance of gastrointestinal epithelium hint at broader, pleiotropic roles, but the strongest common theme appears to be neural development paired with immune signaling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0048672","count":4},{"id":"GO:0050808","count":3},{"id":"GO:0042493","count":3}]},{"hash":"775777218911863055","title":"Pheromone lipid biosynthesis and trafficking","description":"The cluster has strong enrichment for pheromone metabolic processes and multiple fatty acid elongation and sphingolipid biosynthesis terms, pointing to long-chain lipid signals (e.g., cuticular pheromones). The presence of post-Golgi vesicle transport and endosome-to-vacuole sorting suggests these lipids are produced and trafficked via secretory pathways, aligning with pheromone secretion. The courtship behavior term reinforces a behavioral link to mating signaling. Overall, the set appears to reflect pheromone lipid production combined with their cellular trafficking.","confidence":"High","size":20,"edges":178,"triangles":944,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0042810","count":5},{"id":"GO:0042761","count":5},{"id":"GO:0034625","count":5},{"id":"GO:0006892","count":5},{"id":"GO:0030148","count":5}]},{"hash":"854707051280021981","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":143,"triangles":631,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":4},{"id":"GO:0016255","count":3},{"id":"GO:0046425","count":3},{"id":"GO:0050976","count":3},{"id":"GO:0006487","count":3}]},{"hash":"1781413497227537514","title":"Endomembrane trafficking and MVB sorting","description":"The cluster is dominated by GO terms describing intracellular transport within the endomembrane system, including Golgi to endosome and endosome-to-Golgi trafficking, endocytosis, and late endosome/multivesicular body sorting pathways, plus targeting to the vacuole. These together point to a cohesive role in endomembrane trafficking and cargo sorting via multivesicular bodies, with a few outlier terms that are not core to this theme. ","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006895","count":12},{"id":"GO:0034498","count":12},{"id":"GO:0000147","count":12},{"id":"GO:0006915","count":12},{"id":"GO:0006897","count":12}]},{"hash":"854548745047561394","title":"Membrane Transport and Sensory Perception","description":"The cluster centers on membrane-associated functions: chloride and transepithelial transport, visual and taste sensory perception, and surface protein modifications (GPI anchor biosynthesis and O-linked glycosylation). While nuclear envelope/pore terms appear less connected, they may reflect shared membrane biology components. Overall, the proteins seem to participate in membrane transport and sensory signaling rather than a single tightly defined pathway, supporting a label focusing on membrane transport and sensory perception.","confidence":"Medium","size":20,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902476","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0050908","count":3},{"id":"GO:0030321","count":3},{"id":"GO:0051292","count":3}]},{"hash":"653500598730123031","title":"Inflammation and Coagulation Response","description":"The cluster shows strong enrichment for innate immune and inflammatory terms (response to lipopolysaccharide, defense against bacteria, inflammatory response) along with blood coagulation and vascular-related regulation, suggesting a cohesive module linking inflammation, host defense, and coagulation pathways. Some associated terms like pain perception and neurotransmitter secretion may reflect neuroimmune communication within this axis.","confidence":"High","size":20,"edges":41,"triangles":16,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0007596","count":3},{"id":"GO:0001878","count":3},{"id":"GO:0070542","count":3}]},{"hash":"1263440671269979981","title":"Adaptive immune signaling and membrane transport","description":"The top GO terms center on adaptive immune response, T cell proliferation, and Notch signaling, pointing to immune activation and development. Additional terms for xenobiotic and vitamin transport, along with ubiquitin-dependent ERAD and polyubiquitination, suggest linked roles in membrane trafficking and protein quality control that can modulate immune signaling. Overall, the cluster is best described as immune-related with a transport/protein homeostasis theme.","confidence":"Medium","size":20,"edges":79,"triangles":113,"max_degree":15,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002250","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0007584","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0042891","count":4}]},{"hash":"845776046186196828","title":"Unknown","description":"The top GO terms span immune signaling (interferon responses), biotic interactions, skeletal development (bone morphogenesis/mineralization), metabolism (glucose transport with insulin), endosomal trafficking, and neuronal/muscular processes (synaptic vesicle clustering, neuromuscular posture). This wide, disparate mix lacks a single coherent biological theme, and there are no edges linking proteins, so a specific, informative label cannot be assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046597","count":3},{"id":"GO:0060349","count":3},{"id":"GO:0030282","count":3},{"id":"GO:0044381","count":3},{"id":"GO:0099638","count":3}]},{"hash":"2029307544740489031","title":"Glycosylation and glycosphingolipid biosynthesis","description":"Based on the top GO terms, this cluster centers on glycan modification and lipid glycosylation processes, including glycosylceramide metabolism, ganglioside biosynthesis, N-linked glycosylation, oligosaccharide metabolism, and protein sialylation. Although olfactory development terms appear, the shared functions point to glycosylation pathways and glycosphingolipid biosynthesis as the core theme tying these proteins together.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021628","count":5},{"id":"GO:0071699","count":5},{"id":"GO:0006677","count":4},{"id":"GO:0009311","count":4},{"id":"GO:0001574","count":4}]},{"hash":"2241155127826770915","title":"NF-kappaB\u2013driven inflammatory immune response","description":"The top terms cluster around NF-kappaB signaling and transcriptional regulation, cytokine and interleukin production, and broad immune effector activities (viruses defense, neutrophil recruitment, mast cell degranulation, and ADCC), indicating a cohesive NF-kB\u2013mediated inflammatory/immune activation program.","confidence":"High","size":20,"edges":48,"triangles":52,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051092","count":9},{"id":"GO:0002374","count":7},{"id":"GO:0043123","count":7},{"id":"GO:0090197","count":7},{"id":"GO:0051607","count":6}]},{"hash":"1882549509717643910","title":"Mitotic spindle dynamics","description":"This cluster is dominated by GO terms related to mitosis and microtubule-based processes\u2014spindle assembly, centrosome separation, nuclear migration along microtubules, and plus/minus end-directed microtubule sliding\u2014indicating a cohesive theme of spindle organization and microtubule dynamics. The inclusion of related terms like axonemal depolymerization and stress granule disassembly can be contextually linked to microtubule regulation and cellular stress responses, but the central motif remains spindle/microtubule dynamics.","confidence":"High","size":20,"edges":189,"triangles":1122,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090307","count":10},{"id":"GO:0035617","count":10},{"id":"GO:0048364","count":9},{"id":"GO:0007100","count":9},{"id":"GO:0030473","count":8}]},{"hash":"1556438469343775509","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":9},{"id":"GO:0042254","count":7},{"id":"GO:0042273","count":7},{"id":"GO:0000462","count":7},{"id":"GO:0000466","count":6}]},{"hash":"2076018649465506861","title":"Angiogenesis and Growth Factor Signaling Network","description":"The terms cluster around blood vessel formation and growth-factor\u2013driven signaling: angiogenesis, EGFR signaling, ERK/MAPK cascades, Wnt signaling, and PI3P/PI3K biosynthesis, with regulatory aspects and a broader developmental context (thymus development). This supports a cohesive module coordinating angiogenic signaling. ","confidence":"High","size":20,"edges":188,"triangles":1105,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0036092","count":19},{"id":"GO:0001525","count":19},{"id":"GO:0090263","count":19},{"id":"GO:0007173","count":19},{"id":"GO:0070374","count":19}]},{"hash":"1411305221288350715","title":"Wnt- and immune-signaling with ubiquitin regulation","description":"This cluster centers on signaling pathways including canonical/Wnt and planar polarity, T cell receptor and TNF signaling, and regulation of proteolysis via ubiquitination/deubiquitination and proteasomal activity. The convergence of these GO terms suggests proteins that coordinate signal transduction with ubiquitin-regulated proteostasis, potentially linking Wnt signaling to immune responses. ","confidence":"High","size":20,"edges":143,"triangles":681,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0010950","count":16},{"id":"GO:0090263","count":16},{"id":"GO:0050852","count":16},{"id":"GO:0051436","count":15},{"id":"GO:0033209","count":15}]},{"hash":"2084947297669523399","title":"Embryonic skeletal, cartilage, and muscle development","description":"The GO terms cluster around endochondral ossification, trachea/bronchus cartilage development, skeletal muscle differentiation, and lung smooth muscle development, with supportive early embryogenesis terms like primitive streak formation and heart field specification. Together they indicate a mesodermal developmental program focused on skeletal, cartilage, and muscular tissues during embryogenesis.","confidence":"High","size":20,"edges":188,"triangles":1105,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0001958","count":8},{"id":"GO:0003139","count":8},{"id":"GO:0060534","count":8},{"id":"GO:0090009","count":7}]},{"hash":"2125826266951061101","title":"DNA Damage Response and Stress-Induced Cell Cycle Control","description":"Proteins here are linked to DNA replication and transcription, mitotic checkpoint signaling, and transcriptional regulation, plus stress-responsive pathways like JNK signaling, cadmium response, and apoptotic signaling. The cluster appears to bridge DNA damage checkpoints with growth regulation and programmed cell death, reflecting a coherent theme of DNA damage response and stress-induced control of the cell cycle and fate decisions.","confidence":"High","size":20,"edges":167,"triangles":799,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051436","count":3},{"id":"GO:0031571","count":3},{"id":"GO:0071276","count":3}]},{"hash":"630997110682030734","title":"Spliceosome-Driven mRNA Splicing Regulation","description":"The top GO terms are dominated by mRNA splicing and spliceosome regulation (splice-site recognition, regulation of alternative splicing via the spliceosome, cis splicing via the spliceosome). A few terms reflect translation initiation steps, but these appear secondary to the central splicing theme. Thus the cluster most plausibly represents proteins involved in spliceosome-mediated RNA processing and splicing regulation.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":7},{"id":"GO:0000381","count":6},{"id":"GO:1900363","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0001731","count":6}]},{"hash":"1112949720148288734","title":"ECM assembly and connective tissue development","description":"This cluster is dominated by GO terms tied to extracellular matrix formation and connective tissue formation: collagen fibril organization, tendon development, integrin biosynthetic process, and cell adhesion molecule production. These reflect ECM assembly and tissue architecture remodeling. Additional terms on lymphangiogenesis and developmental processes support a tissue-development theme, while complement activation terms may reflect immune interactions in tissue remodeling but don't override the ECM/connective-tissue signal.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":7},{"id":"GO:0001867","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0060355","count":7},{"id":"GO:1901492","count":6}]},{"hash":"151965863177895805","title":"Mitochondrial/Plastid transcription and ribosome assembly","description":"The top GO terms cluster around organelle gene expression: mitochondrial transcription, mitochondrial ribosome assembly, plastid rRNA transcription, and chloroplast/plastid organization, with supporting signals from RNA splicing and regulation of mitochondrial transcription. These indicate a shared function in maintaining and expressing organelle genomes. Some xenobiotic and signaling terms are present but appear peripheral to the main theme. Confidence in this label being representative is High.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0006390","count":1}]},{"hash":"1533554421750210541","title":"T Cell Activation and Innate Immunity","description":"Based on the top GO terms, this cluster is dominated by T cell\u2013mediated activation signals (T cell costimulation and proliferation) and innate immune defenses (innate immune response, defense against Gram-positive bacteria, response to lipopolysaccharide). Fc-epsilon receptor signaling further supports adaptive-innate immune crosstalk. Some terms about angiogenesis and myelination likely reflect inflammation-related tissue remodeling or neuroimmune interactions rather than core immune signaling, but the central theme is immune activation.","confidence":"High","size":20,"edges":44,"triangles":66,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031295","count":6},{"id":"GO:0042102","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0019226","count":5}]},{"hash":"1773104159265524779","title":"Cardiovascular and erythrocyte development with oxidative stress response","description":"The top GO terms point to heart development, erythrocyte maturation, blood coagulation, and multiple oxidative stress responses (nitrosative/hypoxic stress, hydrogen peroxide detoxification, oxidant detoxification), plus protein interactions, suggesting a cohesive module linking heart and red blood cell biology with redox/homeostatic processes. ","confidence":"High","size":20,"edges":123,"triangles":560,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":16},{"id":"GO:0043249","count":16},{"id":"GO:0010764","count":16},{"id":"GO:0009636","count":16},{"id":"GO:0051409","count":16}]},{"hash":"269112243694286618","title":"RNA granule dynamics and mRNA translation control","description":"The cluster is dominated by GO terms related to RNA granules (stress granule assembly, P-body assembly, and cytoplasmic mRNA processing body assembly) and translation regulation (circadian regulation of translation, regulation of cytoplasmic mRNA processing). These point to a coherent theme of post-transcriptional mRNA regulation and RNA granule dynamics, with additional, less central terms like splicing regulation and habituation as minor contributors. Overall, the group appears to function in assembling RNA granules and controlling translation.","confidence":"High","size":20,"edges":73,"triangles":84,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:1905833","count":2},{"id":"GO:0060340","count":2},{"id":"GO:0034063","count":2},{"id":"GO:0002091","count":2}]},{"hash":"1771534287099359924","title":"RNA processing and translation regulation","description":"The cluster\u2019s top GO terms cluster around RNA processing (spliceosome-mediated splicing regulation, mRNA export, polyadenylation), regulatory ncRNA\u2013mediated gene silencing, and translation initiation/control (preinitiation complex formation, IRES-dependent translation). miRNA-mediated silencing is also represented. Although some terms are obsolete, the core signal ties RNA metabolism to translational control and RNA silencing.","confidence":"High","size":20,"edges":181,"triangles":989,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":7},{"id":"GO:0075522","count":6},{"id":"GO:0000381","count":5},{"id":"GO:0048026","count":5},{"id":"GO:1900363","count":5}]},{"hash":"777579854604644497","title":"Neurovascular development and axon guidance","description":"The cluster features angiogenesis and collagen fibril organization (vasculature-related processes) together with multiple axon guidance pathways (semaphorin-plexin signaling, neural crest migration, sympathetic neuron projection, axonal fasciculation). This combination suggests coordinated neurovascular patterning during development, tying blood vessel formation to neural pathfinding.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045907","count":6},{"id":"GO:0030199","count":6},{"id":"GO:0001525","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0048846","count":6}]},{"hash":"1917755819094207614","title":"Transcriptional Regulation and Multi-Tissue Development","description":"This cluster centers on transcriptional control (RNA Pol II) and circadian gene expression, with several tissue-specific development terms (labyrinthine layer morphogenesis, hair cycle, skeletal muscle differentiation, pancreatic beta-cell development). It also includes stress and xenobiotic response terms (oxidative stress-induced senescence, response to xenobiotic stimulus), suggesting a role in coordinating gene expression during development and stress across multiple tissues.","confidence":"Medium","size":20,"edges":145,"triangles":561,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090403","count":19},{"id":"GO:2001038","count":19},{"id":"GO:0060713","count":19},{"id":"GO:2000074","count":19},{"id":"GO:0006366","count":19}]},{"hash":"875498823587013034","title":"Ubiquitin-regulated NF-kappaB immune signaling","description":"The GO terms cluster around regulation of canonical NF-kappaB signaling and ubiquitination (including K48-linked ubiquitination), implying control of proteasomal degradation and signaling. Additional terms on apoptosis, cell cycle regulation, and adaptive immune response suggest a theme of ubiquitin-mediated tuning of immune signaling and transcription. ","confidence":"High","size":20,"edges":11,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":5},{"id":"GO:2000352","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0043066","count":3}]},{"hash":"854399148672202037","title":"Nuclear Transcriptional Regulation in Immune Contexts","description":"The top GO terms cluster around transcription control (negative regulation of RNA Polymerase II transcription; DNA-templated transcription; NF-kappaB-related regulation) and nuclear transport, with supporting themes of innate immune response and immune-related development (placenta), plus centrosome/microtubule associations. This suggests a group of proteins that modulate gene expression in immune-related contexts and coordinate nuclear-cytoskeletal dynamics.","confidence":"Medium","size":20,"edges":102,"triangles":248,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0009190","count":4},{"id":"GO:0007098","count":4},{"id":"GO:0045190","count":3},{"id":"GO:0035372","count":3}]},{"hash":"1758087095130009005","title":"Cardiac morphogenesis and ventricular electrophysiology","description":"The cluster is enriched for heart development terms (outflow tract morphogenesis, left ventricular morphogenesis) and electrical/contractile function (regulation of atrial/ventricular membrane depolarization, ventricular muscle action potential, and stress-induced hypertrophy), pointing to a cohesive heart development and electrical signaling module. The mechanosensory-related terms (detection of mechanical stimuli) and related sensations may reflect mechanotransduction roles in cardiac tissue, supporting the heart-focused theme.","confidence":"High","size":20,"edges":37,"triangles":23,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":20},{"id":"GO:0050976","count":20},{"id":"GO:0019233","count":20},{"id":"GO:0050966","count":20},{"id":"GO:0060371","count":20}]},{"hash":"1318388013703725582","title":"Ubiquitin-Proteasome in Cell Cycle and DNA Repair","description":"The cluster centers on ubiquitin-mediated protein degradation: multiple ubiquitination types (K48, K11), autoubiquitination, SCF- and ERAD-related pathways, and proteasomal catabolism. It also includes cell-cycle processes (anaphase-promoting complex) and DNA repair (nucleotide excision repair), suggesting a common role in regulating protein turnover during cell division and genome maintenance. Therefore the label 'Ubiquitin-Proteasome in Cell Cycle and DNA Repair' appropriately captures the main theme.","confidence":"High","size":20,"edges":57,"triangles":47,"max_degree":10,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070936","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0070911","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0030433","count":5}]},{"hash":"1629892706204712659","title":"Cardiovascular development and cell adhesion signaling","description":"Top terms point to heart and vascular development, integrin-mediated signaling, cell adhesion and spreading, and endothelial chemotaxis, with supporting roles for cytoskeleton dynamics and transcription. A noisy visual perception term appears, but the main signal reflects cardiovascular morphogenesis and adhesion-driven signaling.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007601","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007229","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0007275","count":4}]},{"hash":"42808662299115165","title":"Cell adhesion and neural-synaptic signaling with immune regulation","description":"Based on the top GO terms, the proteins cluster around cell-cell adhesion (heterophilic and homophilic) and processes related to synapse assembly and transmission of nerve impulses, pointing to roles in neural communication. Additional terms involving regulation of immune cell activities (NK and macrophages) and synapse regulation suggest immune-modulatory functions tied to adhesion and neural signaling. Some terms also touch on heart conduction and lung mesenchyme development, which aligns with adhesion/signal transduction roles across tissues. Overall, the common theme is cell adhesion supporting neural signaling with immune regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0007156","count":13},{"id":"GO:0046718","count":12},{"id":"GO:0086072","count":12},{"id":"GO:0043318","count":12}]},{"hash":"587413974618628753","title":"Neural development and axon guidance signaling","description":"This cluster is dominated by GO terms tied to nervous system development and axon growth, including central nervous system projection neuron axonogenesis, corpus callosum development, and ephrin receptor signaling. While a few terms touch on other processes (e.g., protein targeting, telomere maintenance, immune activation), the strongest signal centers on neural development and axon guidance, suggesting proteins function together in nervous system formation and signaling.","confidence":"Medium","size":20,"edges":61,"triangles":48,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050798","count":7},{"id":"GO:0007118","count":7},{"id":"GO:0048013","count":7},{"id":"GO:1904355","count":7},{"id":"GO:0032212","count":7}]},{"hash":"2071688710033120029","title":"Neuronal adhesion and synapse assembly","description":"This cluster is enriched for GO terms related to synapse assembly and neuronal connections (positive regulation of synapse assembly, glutamatergic transmission, neuron adhesion, and nervous system development), indicating a cohesive role in neural connectivity. Some terms about melanin biosynthesis and bone maturation appear but are less representative of the core function; overall, the theme centers on neuron\u2013neuron interactions and synaptic formation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0007157","count":7},{"id":"GO:0007605","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0003273","count":6}]},{"hash":"784370240287895490","title":"Embryogenesis and organ development","description":"This cluster is dominated by GO terms related to embryonic development, left-right pattern formation, and organogenesis, including cartilage morphogenesis, placental and pancreatic cell differentiation, and endocardial cushion EMT. These terms point to a coordinated set of developmental programs governing tissue patterning and organ formation, making a concise label like \"Embryogenesis and organ development\" appropriate and specific.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":10},{"id":"GO:0035270","count":10},{"id":"GO:0003198","count":10},{"id":"GO:0060806","count":10},{"id":"GO:0060536","count":10}]},{"hash":"1148908662799530620","title":"Developmental Cytoskeletal Regulation and Neural Signaling","description":"The cluster combines cytoskeletal control (Rho/GTPase activity) with transcriptional/splicing regulation and neural functions (glutamatergic synaptic transmission and modulation of synaptic plasticity), plus developmental processes (face development). This suggests a coherent theme of developmental regulation affecting cytoskeletal dynamics and neural signaling, despite some broader terms like the mitotic cell cycle.","confidence":"Medium","size":20,"edges":13,"triangles":2,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0043087","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0000381","count":3}]},{"hash":"1104757039337171314","title":"Neuronal synapse formation and adhesion","description":"This cluster is enriched for nervous system development, synapse assembly, and synaptic transmission (including GABAergic), along with cell\u2013cell adhesion and Rho signaling, pointing to coordination of neuronal connectivity and synapse formation. A few terms may be noise (e.g., bone maturation), but the dominant theme is neural development and synaptic function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":12},{"id":"GO:0035023","count":11},{"id":"GO:0007156","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0043931","count":10}]},{"hash":"660374631196766499","title":"Neural Development and Apoptosis Regulation","description":"This cluster centers on brain development (cerebral cortex and corpus callosum, axon regeneration) and includes apoptosis/stress-signaling terms (ER-stress\u2013induced apoptosis, JNK regulation, anoikis) plus cell-cycle/checkpoint processes. The common theme is neural development with regulated cell survival under stress.","confidence":"High","size":20,"edges":11,"triangles":0,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":20},{"id":"GO:0070059","count":20},{"id":"GO:0046329","count":20},{"id":"GO:0072428","count":20},{"id":"GO:0021987","count":20}]},{"hash":"30875644228462858","title":"Unknown","description":"The top GO terms cover a wide and seemingly unrelated mix: signaling pathways (Rho, Wnt, calcium), development and cell movement (smooth muscle development, cellular extravasation), host\u2013symbiont interactions, apoptosis avoidance (anoikis regulation), metabolism (lipoprotein), neuronal structure (dendritic spine maintenance), and even plant-specific chlorophyll biosynthesis. There is no clear, single functional theme tying these proteins together, so a cohesive label is not confidently assignable.","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035024","count":3},{"id":"GO:0048745","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0016055","count":3},{"id":"GO:2000811","count":2}]},{"hash":"82563330109377791","title":"Neuronal GPCR Signaling and Axon Guidance","description":"The top GO terms are dominated by GPCR signaling pathways (adenylate cyclase-activating and PLC-activating), along with neuron-specific processes like axonal fasciculation and synapse assembly, indicating a cluster of proteins involved in GPCR-mediated neuronal signaling and axon development. Some vascular regulation terms and the electron transport chain term may reflect broader cellular signaling and metabolism context, but the core theme is neuronal GPCR signaling linked to axon guidance and synapse formation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0022900","count":18},{"id":"GO:0010579","count":17},{"id":"GO:0051965","count":17},{"id":"GO:1900747","count":17},{"id":"GO:0045777","count":17}]},{"hash":"1881247255414653818","title":"Neural Development and Axon Guidance","description":"These terms converge on neural development and neuronal connectivity: nervous system development; positive regulation of synapse assembly; axon guidance via semaphorin-plexin signaling and neuron projection guidance; clustering of voltage-gated sodium channels; neural crest migration; dendrite self-avoidance; collateral sprouting. Together they point to neuronal pathfinding, synapse formation, and establishment of neural circuits.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0014068","count":8},{"id":"GO:0051965","count":8},{"id":"GO:0045162","count":8},{"id":"GO:0036486","count":7}]},{"hash":"270874424376153146","title":"Development and immune signaling with neural plasticity","description":"The cluster's top GO terms cover insulin receptor signaling, JUN phosphorylation, heart development, immune-related responses (IL-7, B cell maturation, NK T cell differentiation, IL-4 production), cell migration, Rho signaling regulation, and long-term synaptic potentiation. This suggests proteins participate in diverse signaling programs that govern development, immune function, and synaptic plasticity rather than a single pathway. The common thread is signal transduction and transcriptional/regulatory control across multiple tissues, not a specific cellular process.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0008286","count":7},{"id":"GO:0007258","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0098761","count":5},{"id":"GO:0002344","count":5}]},{"hash":"1716466197235194021","title":"ER/Golgi stress response and mitotic regulation","description":"The top GO terms cluster around the ER unfolded protein response, Golgi protein retention, and core mitotic processes (cell division, mitotic sister chromatid cohesion, and regulation of CDK activity), suggesting a group of proteins involved in secretory pathway quality control and coordination of mitosis. Some inositol phosphate metabolism and neural tube development terms appear but are less central to the main theme.","confidence":"Medium","size":20,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0045737","count":2},{"id":"GO:0030968","count":2}]},{"hash":"1578508100053136537","title":"Proteoglycan and glycosaminoglycan biosynthesis","description":"The top GO terms are dominated by biosynthetic and metabolic processes for proteoglycans and glycosaminoglycans (chondroitin sulfate, heparan sulfate, dermatan sulfate), plus proteoglycan metabolic process and related developmental term (chondrocyte development). This suggests the proteins cluster around extracellular matrix assembly and glycosaminoglycan chain synthesis. A few adjacent terms (angiotensin regulation, maltose transport) seem less connected and may be incidental. Overall, a label emphasizing proteoglycan/glycosaminoglycan biosynthesis best captures the shared function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":3},{"id":"GO:0015014","count":3},{"id":"GO:0015015","count":3},{"id":"GO:0002002","count":2},{"id":"GO:0033037","count":2}]},{"hash":"2240836208776367954","title":"Purine nucleotide metabolism and salvage","description":"The top GO terms are dominated by nucleotide phosphorylation and salvage activities (AMP salvage, ADP/CDP biosynthesis, purine ribonucleotide interconversion, ITP metabolism), indicating a cluster centered on purine nucleotide biosynthesis and interconversion. While some development terms (liver/brain development) appear, they likely reflect tissue expression contexts rather than core function, so the main theme is purine nucleotide metabolism and salvage.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0046939","count":11},{"id":"GO:0046940","count":11},{"id":"GO:0046041","count":9},{"id":"GO:0001889","count":9},{"id":"GO:0044209","count":9}]},{"hash":"603313711590266640","title":"Cardiac and neuronal membrane excitability","description":"These GO terms cluster around electrical excitability and membrane potential regulation in excitable tissues. Dominant signals include membrane repolarization and resting potential regulation in cardiac muscle, plus cardiac action potential involvement in contraction. Supporting terms like magnesium transport, glucose response, and glutamate reuptake point to metabolic and neurotransmitter-regulated control of excitability in heart and nervous system, with inflammation-related signaling (TNF) also relevant. Together, they point to ion-channel\u2013driven signaling in cardiac and neural contexts.","confidence":"Medium","size":20,"edges":32,"triangles":41,"max_degree":9,"top_function":"nervous system process","top_go_terms":[{"id":"GO:0098914","count":13},{"id":"GO:0060075","count":13},{"id":"GO:0015693","count":10},{"id":"GO:0071333","count":10},{"id":"GO:0086002","count":10}]},{"hash":"1456998875136849575","title":"Endocytosis and mitophagy under stress","description":"The top GO terms cluster around endocytic processes (endocytosis and regulation of endosome size) and mitochondrial/autophagic turnover (mitophagy by internal vacuole formation, mitochondrial protein catabolic process), along with stress and ischemia responses. This points to a functional theme of intracellular trafficking coupled to mitochondrial quality control under stress, with supporting metabolic remodeling signals. ","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051036","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0002931","count":2},{"id":"GO:0021670","count":2},{"id":"GO:0035694","count":2}]},{"hash":"709613836496686728","title":"GPCR-Driven Neuroendocrine Signaling and Metabolic Regulation","description":"The cluster centers on GPCR signaling pathways (GO:0007186, GO:0007189) with downstream PI3K/AKT modulation and cAMP-related activity, which together align with neuroendocrine control of metabolism, including feeding behavior and glucagon regulation. While some terms (vasodilation, angiogenesis, pregnancy, gamma radiation response) appear ancillary, the dominant theme is GPCR-mediated hormonal/metabolic signaling.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042311","count":3},{"id":"GO:0060055","count":3},{"id":"GO:0010332","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0008343","count":2}]},{"hash":"516496739323313552","title":"Cell cycle and chromatin assembly","description":"The cluster is dominated by terms for cell division, CENP-A containing chromatin assembly, and DNA-templated transcription, with strong representation of ribosome biogenesis and microtubule severing. These together point to a coordinated program of cell-cycle progression with chromatin organization and protein synthesis. Some vesicle transport and ER-associated degradation terms appear as ancillary processes, but they do not define the core theme. ","confidence":"High","size":20,"edges":7,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":14},{"id":"GO:0061641","count":14},{"id":"GO:0006351","count":14},{"id":"GO:0051260","count":14},{"id":"GO:0030433","count":14}]},{"hash":"1638991511220930857","title":"Adipogenesis and inflammatory signaling","description":"This cluster combines adipocyte biology signals (fat cell differentiation, GH receptor signaling) with immune and inflammatory pathways (TNF production, LPS signaling, NF-kappaB-related regulation) and cytoskeletal/migration cues (Rac signaling, cell migration, GTPase activity). These shared themes suggest proteins involved in adipocyte differentiation that also engage inflammatory signaling and migratory dynamics during tissue remodeling. ","confidence":"Medium","size":20,"edges":20,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":5},{"id":"GO:0008285","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0060396","count":3}]},{"hash":"1176477093323221679","title":"Embryonic Morphogenesis Across Tissues","description":"The top GO terms point to developmental and morphogenetic processes across multiple organs (heart, limb, eye, placenta, gonads, brain regions, etc.), indicating a broad embryonic development program rather than a single tissue-specific function. The presence of various organ morphogenesis terms alongside general developmental terms supports a label of embryonic organ morphogenesis or embryonic morphogenesis across tissues.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0035116","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0003148","count":5}]},{"hash":"1574067533031662102","title":"Cardiac metabolism and heart development","description":"The cluster is enriched with terms for heart development and cardiac muscle differentiation, together with metabolic pathways central to cardiac energy production, including fatty acid beta-oxidation, long-chain fatty acid catabolism, carnitine biosynthesis/metabolism, and glycogen biosynthesis. This combination points to proteins involved in heart maturation and energy metabolism.","confidence":"High","size":20,"edges":123,"triangles":438,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":16},{"id":"GO:0055114","count":10},{"id":"GO:0007507","count":8},{"id":"GO:0019254","count":8},{"id":"GO:0009791","count":8}]},{"hash":"453944224701332110","title":"Biosynthesis of Diverse Metabolites","description":"The top GO terms are all biosynthetic processes across a wide range of metabolites (phylloquinone, melanin, glucocorticoids, tetrahydrobiopterin, sphingolipids, fatty acids, alkaloids, etc.), indicating the cluster clusters proteins involved in multiple biosynthetic pathways rather than a single specific pathway. This supports a label centering on broad metabolite biosynthesis.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":20},{"id":"GO:0042376","count":19},{"id":"GO:0042619","count":19},{"id":"GO:0042438","count":19},{"id":"GO:0006704","count":19}]},{"hash":"1142030724721380605","title":"Immune adhesion molecules and cytoskeletal signaling","description":"This cluster features strong representation of cell-cell adhesion terms (homophilic/heterophilic adhesion) and immune regulation (negative regulation of NK and T cell cytotoxicity, cytokine production) along with complement activation and actin cytoskeleton regulation linked to adhesion and synapse assembly, suggesting a coherent theme of immune cell interaction and signaling at adhesion interfaces.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043318","count":13},{"id":"GO:0007157","count":13},{"id":"GO:0002859","count":13},{"id":"GO:0002374","count":12},{"id":"GO:0007156","count":12}]},{"hash":"79428519069898972","title":"Unknown","description":"The listed GO terms are highly diverse, including vitamin D response, regulation of cardiac SA node action potential, microtubule dynamics, autophosphorylation, anoikis regulation, glucose homeostasis, cell size, protein folding, and chemotaxis. There is no clear, shared cellular function or pathway that ties these terms together, so a single cohesive label is not evident.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0046777","count":1},{"id":"GO:2000811","count":1}]},{"hash":"2843380431836595","title":"Cerebral cortex development and neuronal morphogenesis","description":"The cluster centers on neural development and neuronal morphology, with terms describing cortical layer formation, hippocampus development, CNS projection neuron axonogenesis, and dendrite morphogenesis. Additional signals point to Hedgehog pathway regulation and visual perception, while endosomal trafficking and macroautophagy suggest supporting cellular maintenance processes in developing neurons. Overall, the proteins are best described as involved in cerebral cortex development and neuronal morphogenesis, with related trafficking and autophagy functions.","confidence":"High","size":20,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0090305","count":2},{"id":"GO:0008333","count":2},{"id":"GO:0045022","count":2},{"id":"GO:0021819","count":2}]},{"hash":"551529361798032464","title":"Apoptosis and cytokine regulation","description":"The cluster's most represented GO terms center on apoptosis (apoptotic process, apoptotic DNA fragmentation, apoptotic chromosome condensation) and negative regulation of cytokine production, including TNF production. This pattern suggests proteins involved in programmed cell death and immune signaling modulation. Additional terms about positive regulation of protein secretion and stress fiber assembly are present but less dominant, likely reflecting ancillary roles in secretion pathways and cytoskeletal dynamics.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050710","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0050714","count":2},{"id":"GO:0051496","count":2},{"id":"GO:0010890","count":1}]},{"hash":"1930268817667018877","title":"Cardiac Morphogenesis and Electrophysiology","description":"This cluster is dominated by terms related to heart development (outflow tract morphogenesis, left ventricular morphogenesis) and cardiac muscle cell membrane depolarization/repolarization, as well as calcium signaling and smooth muscle contraction, which together point to cardiac structure and electrical activity. While a few terms touch on mechanosensation and general sensory pain, the strongest signal is cardiac development and electrophysiology, making this a cohesive label.","confidence":"Medium","size":20,"edges":43,"triangles":56,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050976","count":20},{"id":"GO:0034465","count":20},{"id":"GO:0051592","count":20},{"id":"GO:0098914","count":20},{"id":"GO:0060083","count":20}]},{"hash":"1189620067295962800","title":"Developmental Morphogenesis","description":"This cluster is enriched for GO terms related to embryogenesis and organ morphogenesis, including left-right patterning, cartilage and hair follicle morphogenesis, placenta and heart cushion development, and palate formation, indicating a shared role in developmental morphogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060536","count":6}]},{"hash":"38977110404241553","title":"Unknown","description":"The top terms span mitosis and kinetochore assembly as well as development (spermatid and nervous system) and lifespan, plus metabolic processes (glycine cleavage, lipoylation) and even viral protein transport. There is no single unifying function linking all terms, suggesting the cluster reflects disparate processes rather than one cohesive role. Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051382","count":2},{"id":"GO:0019464","count":1},{"id":"GO:0009249","count":1},{"id":"GO:0051493","count":1},{"id":"GO:0019060","count":1}]},{"hash":"1323598897577339436","title":"Vertebrate embryonic organ morphogenesis and neural crest development","description":"The top GO terms cluster around embryonic development and morphogenesis across several organs (pancreas, heart, digestive tract, palate, lung, cochlea) and include neural crest formation/migration. This points to a cohesive theme of vertebrate organogenesis with neural crest involvement. A broad regulatory term (negative regulation of transcription) is present but does not redefine the main theme.","confidence":"High","size":20,"edges":173,"triangles":884,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":11},{"id":"GO:0000122","count":11},{"id":"GO:0090190","count":10},{"id":"GO:0001755","count":10},{"id":"GO:0048557","count":10}]},{"hash":"1211623596008397824","title":"Embryonic patterning and morphogenesis","description":"The top GO terms highlight left/right pattern formation, embryonic development (placenta, trophoblast differentiation, pancreas), cartilage morphogenesis, and EMT-related heart formation, all pointing to embryogenesis and tissue morphogenesis. Some terms about splicing and ribosome export are general cellular processes and do not outweigh the developmental theme. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0035270","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6}]},{"hash":"1379389296737196720","title":"Unknown","description":"The top GO terms span kidney and germ-cell development, immune signaling, neural transmission, presynaptic organization, salivary gland specification, and proteolysis, with no single coherent function linking the proteins.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0014068","count":4},{"id":"GO:0045404","count":3},{"id":"GO:0031295","count":3},{"id":"GO:0045214","count":3}]},{"hash":"688977336628252701","title":"Embryonic Tissue Adhesion and Morphogenesis","description":"The terms cluster around cell adhesion (cell-matrix adhesion), and various organ morphogenesis processes (kidney nephron development and endocardial cushion migration), indicating a developmental adhesion theme across tissues; a few unrelated terms exist but the core signal is embryonic tissue adhesion and morphogenesis.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":9},{"id":"GO:0072233","count":7},{"id":"GO:0072218","count":7},{"id":"GO:0003273","count":7},{"id":"GO:0097211","count":7}]},{"hash":"744509372231408464","title":"Unknown","description":"Top GO terms are highly diverse, spanning immune activation (positive regulation of T cell proliferation; immunoglobulin production), cardiac development and electrophysiology (endocardial cushion EMT, atrial cardiomyocyte action potential, regulation of heart rate), epithelial/mucosal interactions (epithelial to mesenchymal transition; chitin-based cuticle attachment to epithelium), membrane modification (peptidyl-L-cysteine S-palmitoylation), gland development (sebaceous gland development), and reproduction (binding of sperm to zona pellucida). With no edges or coherent module linking these functions, there is no single cohesive theme. Therefore Unknown with confidence None.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0042144","count":2},{"id":"GO:0018230","count":2},{"id":"GO:0048733","count":2}]},{"hash":"2024844650576551404","title":"B cell signaling and phagocytosis in immunity","description":"This cluster centers on adaptive and innate immune activation, with strong representation of B cell receptor signaling and classical complement activation, along with phagocytosis and innate immune responses. Additional terms point to cytoskeleton remodeling, cell adhesion, and immune regulation (e.g., T cell degranulation and synapse assembly), suggesting coordinated immune recognition and uptake processes.","confidence":"High","size":20,"edges":21,"triangles":3,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":18},{"id":"GO:0050853","count":18},{"id":"GO:0006910","count":18},{"id":"GO:0045087","count":18},{"id":"GO:0050871","count":18}]},{"hash":"195058856107639358","title":"Embryonic patterning and organ morphogenesis","description":"This cluster is dominated by GO terms related to embryonic development and tissue formation\u2014left/right patterning, heart-associated epithelial-to-mesenchymal transition, cartilage morphogenesis, placenta and pancreatic cell development\u2014indicating a cohesive theme of embryogenesis and organogenesis. Some broader terms on transcriptional and ribosomal regulation reflect general gene expression changes during development but do not conflict with the core pattern. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":15},{"id":"GO:0035270","count":15},{"id":"GO:0003198","count":15},{"id":"GO:0060806","count":15},{"id":"GO:0060536","count":15}]},{"hash":"1910079382210288960","title":"Somite and Skeletal Morphogenesis","description":"Top terms point to somite formation and specification, axis determination, and skeletal development (bone morphogenesis, ossification, muscle differentiation). Notch signaling and pharyngeal system development are consistent with vertebrate segmentation and patterning, defining a cluster centered on somite-driven skeletal organogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":2},{"id":"GO:0001503","count":1},{"id":"GO:0007368","count":1},{"id":"GO:0032525","count":1},{"id":"GO:0060349","count":1}]},{"hash":"1453182759356025985","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning telomere maintenance and telomerase regulation, visual learning and dendritic spine development, imprinting regulation, osmosensory signaling and filamentous/invasive growth, apoptotic regulation, and general signal transduction. There are no shared or cohesive biological processes or pathways that tie these proteins together, and there are no network edges connecting them in this dataset. Because of the lack of a unifying function, this cluster cannot be cleanly labeled with a specific biological theme.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051973","count":2},{"id":"GO:1904355","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0060996","count":2}]},{"hash":"1927050666410347813","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms are dominated by embryonic patterning and morphogenesis\u2014left/right pattern formation, cartilage morphogenesis, EMT in endocardial cushion formation, trophoblast differentiation, placenta development, and endocrine system development\u2014suggesting a cluster of proteins tied to developmental differentiation and tissue structuring, with supporting roles in gene expression regulation and cell cycle processes. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":12},{"id":"GO:0000055","count":12},{"id":"GO:0060972","count":12},{"id":"GO:1903026","count":12},{"id":"GO:0000398","count":12}]},{"hash":"1376193061096585978","title":"Dopaminergic Neuropeptide Signaling in Nervous System","description":"This cluster is dominated by terms related to neural communication and modulation, including neuropeptide signaling, dopaminergic synaptic transmission, and regulation of dopamine receptor signaling, as well as related nervous system development and behavior terms (e.g., grooming, sensory perception of pain). While a few terms touch on non-neural processes, the prevalent theme is neural signaling and dopamine/neuropeptide pathways, supporting a label focused on nervous system signaling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":20},{"id":"GO:0072224","count":20},{"id":"GO:0060160","count":20},{"id":"GO:0048484","count":20},{"id":"GO:2000458","count":20}]},{"hash":"143007249411768155","title":"Dopaminergic Neuronal Signaling and Behavior","description":"The GO terms cluster around nervous system development and signaling, particularly dopaminergic synaptic transmission, neuropeptide signaling, and regulation of dopamine receptor signaling, plus behavioral aspects like grooming and pain perception. Other terms may reflect broader autonomic or developmental connections, but the dominant theme is dopamine/neuronal signaling and related behaviors.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":20},{"id":"GO:0072224","count":20},{"id":"GO:0060160","count":20},{"id":"GO:0048484","count":20},{"id":"GO:2000458","count":20}]},{"hash":"1890363583419110024","title":"Neural and Cardiac Development Signaling","description":"This cluster is enriched for nervous system development (including corpus callosum development), heart development, and angiogenesis, along with PI3K/AKT signaling and immune-related processes (T cell receptor signaling, apoptotic cell clearance, neutrophil clearance). The shared theme appears to be proteins involved in coordinating neural and cardiovascular development with related signaling and immune activities.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007399","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0097350","count":5},{"id":"GO:0042220","count":5},{"id":"GO:0022038","count":5}]},{"hash":"217433965853947618","title":"Mitochondrial Transporters and Energetics","description":"This cluster is driven by GO terms for transmembrane transport of various cofactors and ions across mitochondrial membranes (e.g., pyridoxal phosphate, thiamine pyrophosphate, thiosulfate, phosphate, iron), plus metabolic processes like the malate-aspartate shuttle and adaptive thermogenesis, and mitochondrial-associated apoptotic changes. The pattern points to coordinated mitochondrial transport and energy regulation as the core theme.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0031921","count":20},{"id":"GO:1990314","count":20},{"id":"GO:0015709","count":20},{"id":"GO:0008637","count":20},{"id":"GO:0043490","count":20}]},{"hash":"2288502551238818534","title":"Neurodevelopment and Neuropeptide Signaling","description":"The cluster is dominated by GO terms related to nervous system development and signaling, including enteric nervous system development, neuropeptide signaling, sensory perception of pain, grooming behavior, and regulation of astrocyte chemotaxis, plus modulation of dopamine receptor signaling and ERK cascade activity. While a couple terms (saliva secretion, metanephric glomerulus development) are non-neural, they can be tied to autonomic or signaling pathways affecting peripheral tissues. Overall, the shared theme points to neural signaling and development as the core function of this set.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":16},{"id":"GO:0046541","count":15},{"id":"GO:0072224","count":15},{"id":"GO:0060160","count":15},{"id":"GO:0048484","count":15}]},{"hash":"607773488876436146","title":"Nervous system development and signaling","description":"This cluster is dominated by GO terms tied to nervous system growth and function: enteric nervous system development, neuropeptide signaling, dopamine signaling regulation, astrocyte chemotaxis, nociception (pain perception), and grooming behavior. While a few terms (like saliva secretion or certain organ development terms) are broader, the strongest and most frequent signals point to neural development and signaling as the unifying theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060427","count":20},{"id":"GO:0060658","count":20},{"id":"GO:0046541","count":19},{"id":"GO:0072224","count":19},{"id":"GO:0060160","count":19}]},{"hash":"976235696429182148","title":"GPI Anchor Biosynthesis and Photoreceptor Maintenance","description":"The strongest signals are GPI anchor biosynthesis and visual system-related terms (visual perception and photoreceptor cell maintenance), suggesting a module focused on membrane-anchored proteins that support photoreceptor integrity. Additional terms touch on cell morphogenesis, autophagy, and stress responses, but the core theme centers on membrane protein maturation and photoreceptor maintenance.","confidence":"Medium","size":19,"edges":95,"triangles":299,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":4},{"id":"GO:0050884","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0000902","count":3},{"id":"GO:0042771","count":2}]},{"hash":"978473915899189196","title":"Lipid Metabolism and Lipoprotein Regulation","description":"The top GO terms cluster around triglyceride biosynthesis, very-low-density lipoprotein particle assembly, cholesterol efflux, and cholesterol homeostasis, together pointing to lipid handling and lipoprotein regulation; related terms on foam cell differentiation and protein palmitoylation further support lipid processing and modification processes.","confidence":"High","size":19,"edges":167,"triangles":905,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":12},{"id":"GO:0034379","count":11},{"id":"GO:0033344","count":11},{"id":"GO:0042121","count":11},{"id":"GO:0034435","count":11}]},{"hash":"1970348969230906763","title":"Auditory and neural signaling proteins","description":"The top GO terms cluster around hearing-related and neural signaling functions: cochlea development, sensory perception of sound, serotonin receptor signaling, and regulation of nerve impulse transmission, with supporting ion transport and autonomic heart-rate regulation terms. This combination suggests a cohesive group of proteins involved in auditory system development and neural signaling, with related ion transport and cardiovascular modulation.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0001988","count":19},{"id":"GO:2001226","count":19},{"id":"GO:0035725","count":19},{"id":"GO:0051970","count":19},{"id":"GO:0090102","count":19}]},{"hash":"1178430346988047072","title":"Unknown","description":"The terms cluster around auditory receptor function (stereocilium organization and detection of mechanical stimulus) but also include bone development/mineralization, insulin-responsive glucose transport, endosomal trafficking, and immune responses. Because these GO terms do not converge on a single functional theme, there is no coherent label that accurately represents the entire set.","confidence":"","size":19,"edges":10,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060088","count":3},{"id":"GO:0050910","count":3},{"id":"GO:0046597","count":3},{"id":"GO:0060349","count":3},{"id":"GO:0030282","count":3}]},{"hash":"603032077151763226","title":"Lipid biosynthesis and T cell regulation","description":"The cluster is enriched in lipid metabolism terms (triglyceride biosynthesis, CDP-diacylglycerol biosynthesis, phosphatidylcholine remodeling) alongside immune signaling terms (interleukin-2 production, negative regulation of activation-induced T cell death), suggesting a cohesive module linking membrane lipid provisioning with T cell\u2013related regulation. Mitochondrial ATP synthesis supports the energy demands of these biosynthetic and signaling processes, while development-related terms appear less central. Overall, the dominant theme ties lipid biosynthesis to immune regulation.","confidence":"Medium","size":19,"edges":111,"triangles":345,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":16},{"id":"GO:0016024","count":11},{"id":"GO:0070970","count":11},{"id":"GO:0070236","count":11},{"id":"GO:0042775","count":11}]},{"hash":"2140757713269219914","title":"Neural development and actin remodeling","description":"This cluster is dominated by GO terms tied to nervous system development (brain and nervous system development, neuron maturation, cochlea morphogenesis) and cytoskeletal regulation (pseudopodium assembly, actin filament polymerization, Cdc42 signaling), indicating a cohesive module of neuronal development coupled with actin cytoskeleton dynamics.","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0031274","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0000060","count":2},{"id":"GO:0007399","count":2}]},{"hash":"1934784783084509894","title":"Visual perception and retinoid metabolism","description":"The cluster is dominated by GO terms related to vision and retinal metabolism (retinol/retinal metabolic processes, phototransduction, visual perception, detection of light stimulus, retina morphogenesis), suggesting proteins involved in the visual system; a few terms like strigolactone biosynthesis appear but are less represented, so the label focuses on retina/vision.","confidence":"High","size":19,"edges":42,"triangles":56,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009405","count":5},{"id":"GO:0042572","count":4},{"id":"GO:0051692","count":4},{"id":"GO:0006689","count":4},{"id":"GO:0007604","count":3}]},{"hash":"1820948300166286574","title":"Retina development and photoreceptor differentiation","description":"The strongest signals cluster around eye/retina development and photoreceptor differentiation (visual perception, retina vasculature development in camera-type eye, camera-type eye photoreceptor cell differentiation). Additional terms point to developmental signaling (Notch) and cell adhesion/receptor dynamics (receptor internalization, integrin signaling), which fit retinal maturation processes. Some terms (heart development, LPS response) may reflect pleiotropy or incidental associations, but the dominant theme is retina/eye development and photoreceptor differentiation.","confidence":"Medium","size":19,"edges":14,"triangles":1,"max_degree":3,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0031623","count":6},{"id":"GO:0007601","count":5},{"id":"GO:0032496","count":4},{"id":"GO:0045747","count":4}]},{"hash":"1603238911426713933","title":"Transcriptional Regulation and RNA Processing","description":"This cluster centers on control of gene expression at multiple levels: transcriptional regulation (negative regulation of RNA Pol II, chromatin remodeling), RNA processing (alternative splicing via spliceosome, RNA export regulation), and post-translational modulation (deubiquitination). The inclusion of stress-related terms (hypoxia response, DNA damage response) suggests these proteins coordinate expression in response to stress, rather than representing a single metabolic pathway. Overall, the common theme is multi-level regulation of gene expression.","confidence":"Medium","size":19,"edges":66,"triangles":99,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0090526","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006977","count":1},{"id":"GO:0000381","count":1},{"id":"GO:1990168","count":1}]},{"hash":"1978682663118598162","title":"DNA Damage Response and RNA Metabolism","description":"This cluster centers on nucleic acid maintenance: RNA quality control (nonsense-mediated decay), DNA damage response (SOS), repair and replication-related processes, and RNA/rRNA processing, indicating a theme of genome integrity and RNA metabolism.","confidence":"High","size":19,"edges":130,"triangles":553,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000184","count":5},{"id":"GO:0009432","count":5},{"id":"GO:0006306","count":4},{"id":"GO:0006269","count":4},{"id":"GO:0006289","count":4}]},{"hash":"293206627312104561","title":"Ribosome biogenesis and translation machinery","description":"The cluster is heavily enriched for translation and ribosome biogenesis terms (translation, ribosome biogenesis, nucleolar rRNA transcription) and includes RNA polymerase activities (I/II/III) and nucleologenesis, suggesting proteins that drive ribosome production and associated nucleolar transcription/organization, with some ncRNA-related chromatin regulation points that align with nucleolar function.","confidence":"High","size":19,"edges":141,"triangles":575,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0042254","count":3},{"id":"GO:0001172","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0042797","count":2}]},{"hash":"181422619736718045","title":"ESCRT-mediated MVB trafficking and viral budding","description":"The top GO terms cluster around ubiquitin-dependent degradation via multivesicular bodies, MVB assembly, and ESCRT-mediated viral budding, indicating a core function in ESCRT/MVB-based vesicle trafficking and virus budding interactions. Related terms about Golgi retention and cell cycle processes likely reflect broader trafficking and cellular stress roles, but the dominant signal is ESCRT/MVB sorting and budding. ","confidence":"High","size":19,"edges":148,"triangles":656,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0043162","count":9},{"id":"GO:1904669","count":9},{"id":"GO:0036258","count":9},{"id":"GO:0039702","count":9},{"id":"GO:1902188","count":9}]},{"hash":"1968858814689352732","title":"Chromosome Segregation and Septin Organization","description":"The cluster is enriched for mitotic/meiosis-related processes such as sister chromatid biorientation, meiotic cohesion, spindle orientation checkpoint signaling, and septin ring organization/disassembly, along with protein localization to chromosomes and related trafficking. This points to a cohesive module coordinating chromosome segregation and septin-based cytokinesis.","confidence":"High","size":19,"edges":109,"triangles":393,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0070199","count":4},{"id":"GO:0007165","count":4},{"id":"GO:0051388","count":4},{"id":"GO:0031107","count":4},{"id":"GO:0090005","count":4}]},{"hash":"1004822399933911529","title":"Neural development and synapse assembly signaling","description":"These proteins are enriched for nervous system development, synapse assembly, and cell\u2013cell adhesion, with supporting signaling pathways such as ERK, FGFR, STAT phosphorylation, and PI3K. Angiogenesis and innate immune response terms also appear, suggesting roles in neurovascular development and CNS immune functions. Overall, the cluster centers on neural development with synapse formation and related signaling networks.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":12},{"id":"GO:0007157","count":12},{"id":"GO:0045087","count":11},{"id":"GO:0051965","count":11},{"id":"GO:0007156","count":11}]},{"hash":"1831048563826512612","title":"Endosomal-lysosomal Vesicle Trafficking","description":"This cluster centers on endosome-to-lysosome transport, endosome and lysosome organization, and vesicle docking/tethering in exocytosis, consistent with neuromuscular synaptic transmission and vacuole inheritance; together these terms point to a cohesive vesicle trafficking program across endolysosomal and secretory pathways, including synaptic vesicle release.","confidence":"High","size":19,"edges":65,"triangles":133,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":3},{"id":"GO:0006904","count":3},{"id":"GO:0045022","count":2},{"id":"GO:0007040","count":2},{"id":"GO:0007032","count":2}]},{"hash":"1556783131820292711","title":"Bone and cartilage development","description":"The proteins in this cluster are linked by several GO terms related to cartilage condensation, intramembranous and endochondral ossification, collagen catabolic processes, and cell adhesion, all pointing to skeletal development and extracellular matrix remodeling. Some terms (e.g., complement activation) may be less aligned and could reflect annotation noise, but the dominant signals support a bone/cartilage formation theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0001502","count":6},{"id":"GO:0060355","count":6},{"id":"GO:0051873","count":6},{"id":"GO:0035987","count":6}]},{"hash":"2030664842447651808","title":"Glycolysis and glucose metabolism","description":"These terms cluster around glucose handling and glycolytic flux: glucose detection, fructose/mannose carbohydrate metabolism, hexokinase-dependent signaling, and regulation of glycolysis, plus related NADP+ metabolism and mitochondrial permeability processes. Taken together, the proteins likely form a module involved in glycolysis, carbohydrate metabolism and energy sensing.","confidence":"High","size":19,"edges":143,"triangles":642,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001678","count":6},{"id":"GO:0006013","count":6},{"id":"GO:0019660","count":6},{"id":"GO:0009747","count":6},{"id":"GO:0006002","count":6}]},{"hash":"772520469652116308","title":"Neuroendocrine Developmental Signaling","description":"The cluster includes GO terms tied to tissue development (fat cell differentiation, heart, placenta, mammary alveolus) alongside neuroendocrine processes (dopaminergic synaptic transmission, norepinephrine biosynthesis) and signaling regulation (GPCR desensitization, peptidyl-threonine phosphorylation), suggesting a theme of endocrine-related development coupled with neural signaling pathways.","confidence":"Medium","size":19,"edges":54,"triangles":34,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0001893","count":3},{"id":"GO:0018107","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1902905172742577363","title":"Angiogenesis with ERK signaling and ECM-immune interactions","description":"This cluster centers on endothelial signaling driving angiogenesis, including ERK pathway regulation, cell-surface localization, and cell-matrix adhesion, with supporting ECM proteoglycan biosynthesis and inflammatory/immune cues. The mix suggests proteins involved in vascular remodeling and associated immune responses at the cell surface.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0001525","count":7},{"id":"GO:0034394","count":7},{"id":"GO:0035641","count":5},{"id":"GO:0002250","count":5}]},{"hash":"866627326117822167","title":"Cardiac GPCR signaling and contraction regulation","description":"The cluster\u2019s top GO terms converge on heart-related processes, especially GPCR signaling involving acetylcholine and tachykinin receptors, GPCR desensitization and internalization, and modulation of heart muscle contraction and sodium transport, indicating a coherent theme of cardiac GPCR-mediated signaling and contraction regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:1903526","count":3},{"id":"GO:0003108","count":3},{"id":"GO:0007213","count":3},{"id":"GO:0018107","count":3}]},{"hash":"1430127340484585070","title":"Developmental morphogenesis and organ identity regulation","description":"During development, many terms refer to tissue formation and cell fate decisions (cranial skeletal system development, endodermal fate commitment, oocyte localization, fungiform papilla formation, root development), complemented by processes that shape tissues (mitotic cytokinesis, GTPase activity, apoptosis) and organ maintenance (maintenance of animal organ identity). The diversity suggests a broad developmental program rather than a single pathway, so the label reflects the overarching theme of development and organ specification.","confidence":"Medium","size":19,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0086091","count":3},{"id":"GO:1904888","count":3},{"id":"GO:0048364","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000281","count":3}]},{"hash":"1856099949629432477","title":"RNA processing and translation regulation","description":"The cluster centers on RNA metabolism: regulation of splicing via spliceosome, mRNA export, polyadenylation, and regulatory ncRNA\u2013mediated silencing, together with translation initiation complex assembly and miRNA-mediated translation repression, indicating coordinated control of RNA processing and downstream translation. ","confidence":"High","size":19,"edges":156,"triangles":819,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":18},{"id":"GO:0048026","count":18},{"id":"GO:1900363","count":18},{"id":"GO:0031047","count":18},{"id":"GO:0001731","count":18}]},{"hash":"1641243451505080849","title":"ECM Remodeling with Angiogenesis and Coagulation","description":"The cluster is enriched for extracellular matrix-related terms (cell-matrix adhesion, elastic fiber assembly, collagen fibril organization, skeletal system development) along with vascular/platelet processes (negative and positive regulation of angiogenesis, platelet activation, blood coagulation, fibrin clot formation) and calcium response, suggesting coordinated ECM remodeling that influences blood vessel formation and hemostasis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":5},{"id":"GO:0048251","count":5},{"id":"GO:0016525","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1488236296421823485","title":"UV-Induced DNA Repair and Transcription Regulation","description":"The GO terms cluster around transcription-coupled and pyrimidine-dimer nucleotide-excision repair, responses to UV-B/C, and regulation of transcription and the cell cycle, all pointing to a core function in UV-induced DNA damage response and repair, with some developmental annotations likely pleiotropic or contextual. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0040034","count":3},{"id":"GO:0006283","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0071157","count":3},{"id":"GO:0010224","count":3}]},{"hash":"2047292986297922207","title":"Cardiac muscle contraction and calcium signaling","description":"The top GO terms point to heart contraction, regulation of cardiac muscle membrane potential, and calcium release from the sarcoplasmic reticulum, reflecting involvement in excitation-contraction coupling and calcium handling in cardiac tissue; a few morphogenesis terms likely reflect broader developmental roles or annotation noise, but the core signal is cardiac function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060047","count":3},{"id":"GO:0097202","count":3},{"id":"GO:0060021","count":2},{"id":"GO:1901846","count":2},{"id":"GO:0060325","count":2}]},{"hash":"2126445185219950997","title":"Developmental Regulation and Cell Fate","description":"The terms cluster around developmental processes and cell fate decisions (endodermal fate, oocyte localization, papilla formation, maternal involvement) and regulatory mechanisms (negative/positive regulation of proliferation, apoptosis, ubiquitination). While a viral process term appears, the dominant theme is development and cell fate control with post-translational regulation (ubiquitination) and nuclear transport (ribosomal protein import), which commonly occur together in developmental contexts.","confidence":"Medium","size":19,"edges":40,"triangles":13,"max_degree":9,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0008285","count":4},{"id":"GO:0016032","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0060135","count":3},{"id":"GO:0060561","count":3}]},{"hash":"1455077171202636809","title":"Dendritic spine morphogenesis and synapse assembly","description":"The cluster is dominated by terms related to synaptic placement and formation (protein localization to synapse, receptor clustering, dendritic spine morphogenesis) and signaling pathways (Rho signaling, Wnt canonical signaling) that drive spine development and synaptic organization. While some developmental terms like cartilage condensation and keratinocyte differentiation appear, the strongest signal points to neuronal synapse formation and dendritic spine maturation.","confidence":"High","size":19,"edges":56,"triangles":56,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008285","count":17},{"id":"GO:0007266","count":17},{"id":"GO:0035418","count":17},{"id":"GO:0043113","count":17},{"id":"GO:0060997","count":17}]},{"hash":"1236448102935230122","title":"Iron transport and detoxification","description":"This cluster consistently shows GO terms tied to iron ion handling: transport, siderophore-iron import, detoxification, and related enzyme regulation, indicating a coherent iron homeostasis function. Some terms like chromosome condensation or stress response appear less central, but do not outweigh the iron-focused signal.","confidence":"High","size":19,"edges":55,"triangles":45,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006880","count":5},{"id":"GO:0030261","count":5},{"id":"GO:0006950","count":5},{"id":"GO:0033214","count":5},{"id":"GO:0048147","count":5}]},{"hash":"1965929294730885242","title":"Rho-regulated Actin Organization and Cell Polarity","description":"This cluster is dominated by GO terms for Rho GTPase signaling, regulation of actin filament assembly and crosslinking, and processes that shape cell polarity and morphology (microspike formation, actin cortical patch localization, and cell-shape maintenance). While it also includes heart development and synaptic potentiation terms, the core signal is Rho-mediated actin remodeling driving cytoskeletal organization and polarity. ","confidence":"High","size":19,"edges":123,"triangles":418,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":15},{"id":"GO:0043547","count":13},{"id":"GO:0030035","count":12},{"id":"GO:1900042","count":12},{"id":"GO:0051017","count":12}]},{"hash":"1926943589503230701","title":"Neural development and axon guidance","description":"The cluster is dominated by terms related to neural development, including motor neuron axon guidance, Schwann cell development, and synapse assembly, supported by signaling pathways like Wnt, ERK/MAPK, and STAT phosphorylation that drive neural differentiation and peripheral nervous system formation. Some terms (cartilage condensation, cardiac muscle proliferation) suggest broader developmental signaling, but the prevailing theme centers on neural patterning and connectivity.","confidence":"High","size":19,"edges":95,"triangles":306,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008045","count":17},{"id":"GO:0060045","count":16},{"id":"GO:0090314","count":16},{"id":"GO:0042523","count":16},{"id":"GO:0090263","count":16}]},{"hash":"999236644266979059","title":"Embryonic patterning and organogenesis","description":"This cluster centers on developmental processes across tissues: left/right patterning, endocrine system development, EMT in endocardial cushion formation, placental differentiation, cartilage morphogenesis, trophoblast giant cell differentiation, pancreatic cell development, and palate formation. The terms point to a broad embryogenesis/morphogenesis theme rather than a single tissue-specific function, with a housekeeping term (mRNA splicing) appearing as a secondary facet. Overall, a broad developmental morphogenesis label fits the dominant signal.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":12},{"id":"GO:0035270","count":12},{"id":"GO:0003198","count":12},{"id":"GO:0060806","count":12},{"id":"GO:0060536","count":12}]},{"hash":"1090968305871999497","title":"Cross-tissue Development and Immune Signaling","description":"The set features developmental processes across multiple tissues (skin development, podocyte development, fat cell differentiation) alongside immune- and inflammation-related processes (platelet activation, monocyte chemotactic protein-1 production, granulocyte differentiation regulation, hypochlorous acid biosynthesis, and PKA signaling). This mix suggests a cluster of proteins involved in tissue differentiation that also participate in immune signaling and inflammatory responses, rather than a single, narrow function.","confidence":"Medium","size":19,"edges":155,"triangles":732,"max_degree":18,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0043588","count":12},{"id":"GO:0071230","count":12},{"id":"GO:0030168","count":9},{"id":"GO:0045715","count":9},{"id":"GO:0002149","count":9}]},{"hash":"1741424480015774592","title":"Mammary gland epithelial proliferation and lactation","description":"Clustering genes shows a strong tilt toward mammary gland biology: epithelial cell proliferation, lactation, and developmental growth, supported by cell-cycle regulation and insulin signaling modulation. While a few terms touch on heart morphogenesis or ciliogenesis, the prominent signals across the cluster point to mammary gland epithelial growth and lactation processes.","confidence":"Medium","size":19,"edges":18,"triangles":4,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003007","count":3},{"id":"GO:0071481","count":3},{"id":"GO:0000320","count":3},{"id":"GO:0033598","count":3},{"id":"GO:0045737","count":3}]},{"hash":"532527736161563923","title":"Immune differentiation and developmental morphogenesis","description":"Most frequent GO terms point to differentiation of immune cells (dendritic cells, memory T cells, germinal centers) and developmental morphogenesis (left/right patterning, endocardial cushion EMT, distal tubule morphogenesis). This suggests a cluster of regulators involved in cell fate decisions across immune and developmental contexts. Some terms (circadian sleep/wake cycle, ubiquitin-dependent processes) indicate broader regulatory roles beyond direct differentiation, but the core theme appears to be differentiation and morphogenesis. ","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060972","count":3},{"id":"GO:0043380","count":3},{"id":"GO:0031397","count":3}]},{"hash":"9086543039518225","title":"Developmental signaling and organogenesis","description":"This cluster shows enrichment for heart development, neuron projection development, organ induction, and multicellular organism development, along with regulation of key signaling pathways (ERK/MAPK and Ras) and cytoskeletal dynamics (microtubule polymerization). These terms point to proteins involved in developmental signaling and the formation of organs and neural structures, indicating a cohesive theme of developmental regulation and morphogenesis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0031116","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0001759","count":2}]},{"hash":"1235126826641495828","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around diverse developmental and morphogenetic processes, including heart cushion EMT, palate formation, left-right patterning, placental and trophoblast differentiation, cartilage morphogenesis, and pancreatic cell development. These collectively point to embryogenesis and tissue formation rather than a single tissue-specific function, with a couple of general terms likely reflecting background cellular processes. Confidence: High","confidence":"","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0060021","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3}]},{"hash":"1050001601134438041","title":"Embryonic Morphogenesis and Neural Differentiation","description":"The top GO terms point to embryonic tissue and limb/skeletal morphogenesis (hindlimb, forelimb, digits, skeletal system, roof of mouth) alongside neural development and differentiation (cerebral cortex regionalization, neuronal commitment, visceral motor neuron differentiation, pituitary development). This suggests a cohesive theme of embryonic morphogenesis with concurrent neural specification and differentiation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035116","count":5},{"id":"GO:0003148","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0042733","count":4},{"id":"GO:0021983","count":4}]},{"hash":"38384194302683381","title":"Neuronal signaling and sensory perception","description":"This cluster is dominated by terms tied to neural communication and sensory processes: GPCR-mediated glutamate signaling, calcium import, sodium ion transport, cellular responses to electrical stimuli, light perception, and memory. While a few terms (e.g., oocyte maturation, fungicide response, electron transport) are broader, the strongest, most frequent signals point to neuronal signaling and sensory processing.","confidence":"Medium","size":19,"edges":45,"triangles":37,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":19},{"id":"GO:0035725","count":19},{"id":"GO:0030818","count":19},{"id":"GO:0060992","count":19},{"id":"GO:0090280","count":19}]},{"hash":"222658310049050998","title":"Neural development and synaptic adhesion","description":"The dominant GO terms point to nervous system development, synapse assembly, and neuron cell\u2013cell adhesion (including homophilic/heterophilic adhesion), indicating a neural-development/synaptic connectivity theme. While other terms touch bone maturation, nephron development, melanin biosynthesis, and B cell differentiation, these appear less central to the cluster's core function. Overall, the proteins likely participate in neural development and synaptic interactions.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":12},{"id":"GO:0051965","count":11},{"id":"GO:0007156","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0043931","count":9}]},{"hash":"1734221470674028653","title":"Skeletal and Cardiac Muscle Development","description":"The cluster is dominated by muscle-related terms: sarcomere organization, skeletal muscle fiber development, heart development, cardiac muscle contraction, and actin cytoskeleton organization, indicating a cohesive module around muscle structure and function (skeletal and cardiac). Some peripheral terms (retina layer formation, synaptic vesicle endocytosis, ceramide transport) are present but do not override the muscle theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0010842","count":3},{"id":"GO:1900242","count":3},{"id":"GO:0048741","count":3}]},{"hash":"906628682343548599","title":"Neural/glial development and cytoskeletal dynamics","description":"Dominant terms depict axonogenesis and Schwann cell development, pointing to neural development in the peripheral nervous system. Additional terms about actin cytoskeleton reorganization and sarcomere organization support a theme of cytoskeletal remodeling in neural/glial contexts. Less cohesive terms (fat cell differentiation, telomere maintenance, etc.) appear but do not override the central neural/cytoskeletal signal.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007409","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0032212","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0042997","count":2}]},{"hash":"794500969255987502","title":"Endosomal-Vacuolar Trafficking","description":"Dominant GO terms center on vesicle transport between Golgi, endosomes, and vacuoles (e.g., protein targeting to vacuole, endocytosis, Golgi\u2013endosome transport, multivesicular body sorting, late endosome\u2013vacuole transport). These consistently map to endosomal/vacuolar trafficking, with supporting terms like actin patch assembly involved in endocytosis. Some outliers (pregnancy, cardioblast specification) appear incidental, but the core signal is cohesive endosomal/vacuolar sorting.","confidence":"High","size":19,"edges":14,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006623","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0071985","count":2},{"id":"GO:0000147","count":2}]},{"hash":"1258095489603089684","title":"Embryogenesis and Organ Morphogenesis","description":"The top GO terms point to broad developmental and differentiation processes across multiple tissues\u2014left/right patterning, placenta and heart-related development, cartilage formation, pancreatic cell development, spinal interneuron specification, and related signaling. This suggests a cluster of proteins involved in embryonic patterning and organogenesis rather than a single specific pathway, so a general developmental theme fits best.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2}]},{"hash":"1878941503051783107","title":"Angiogenesis Regulation in Reproductive Tissues","description":"The top GO terms cluster around negative regulation of angiogenesis and endothelial cell migration (e.g., negative regulation of sprouting angiogenesis and endothelial chemotaxis), combined with reproductive-context terms like embryo implantation and estradiol response. This suggests a cohesive theme of vascular remodeling and epithelial/placental remodeling in reproductive biology. Other terms (circadian cycle, keratinocyte differentiation, lamellipodium assembly) reflect related cell-migration and tissue-structure processes that can occur in these contexts. Overall, the functions point toward regulation of angiogenesis within reproductive tissues, with related differentiation and migration processes.","confidence":"Medium","size":19,"edges":44,"triangles":31,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":2},{"id":"GO:0060548","count":2},{"id":"GO:0042747","count":2},{"id":"GO:0090051","count":2},{"id":"GO:0010226","count":2}]},{"hash":"2068410341911209159","title":"Mitochondrial translation and oxidative phosphorylation","description":"The dominating GO terms center on translation (protein synthesis and fidelity) and energy production via oxidative phosphorylation and proton-motive ATP synthesis, suggesting these proteins participate in mitochondrial ribosome/function linked to respiration. A few terms (cell cycle, siRNA processing) are peripheral or less specific, but the main theme points to translation machinery connected to mitochondrial energy metabolism.","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0015986","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0099132","count":1},{"id":"GO:0006450","count":1}]},{"hash":"1959780706649955694","title":"Glycosylation and cell wall biosynthesis","description":"The top GO terms cluster around glycosylation pathways (glycosphingolipid biosynthesis, various glycosylation processes) and cell wall-related processes (cell wall organization, seed coat mucilage biosynthesis, adhesion-related terms). This points to a group of proteins involved in building and modifying glycan structures on the cell surface and in cell wall components, including plant-specific mucilage and epitope biosynthesis. Therefore, a label capturing both glycan biosynthesis and cell surface/cell wall assembly is appropriate.","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":7},{"id":"GO:0006688","count":6},{"id":"GO:0030259","count":6},{"id":"GO:0033580","count":6},{"id":"GO:0071555","count":4}]},{"hash":"2297434589104948356","title":"Neural signaling and nervous system development","description":"The top GO terms are strongly neural-focused: GPCR signaling in neurons, sensory perception of pain, dopamine receptor signaling regulation, enteric nervous system development, and astrocyte chemotaxis, with additional autonomic-related terms such as saliva secretion and blood pressure regulation pointing to nervous system control. A couple of terms (energy metabolism, kidney development) appear ancillary, but the central theme is neural signaling and nervous system development. ","confidence":"High","size":19,"edges":139,"triangles":525,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0045777","count":19},{"id":"GO:0035025","count":19},{"id":"GO:0046541","count":18}]},{"hash":"1531791422385797434","title":"Mammary gland development and cell cycle regulation","description":"The GO terms point to mitotic processes (spindle assembly, cell division, re-entry into mitotic cell cycle, CDK activity) combined with mammary gland biology (mammary gland epithelial cell proliferation, lactation) and signaling regulation (insulin receptor signaling, ephrin pathways), suggesting a theme of proliferative development in mammary tissue coordinated by cell-cycle and signaling controls. Some neuronal signaling terms appear, but the dominant signal is mammary gland proliferation linked to cell-cycle regulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:1900383","count":3},{"id":"GO:0051225","count":3},{"id":"GO:1901187","count":3},{"id":"GO:0000320","count":2}]},{"hash":"2146873491640347453","title":"Cardiac and retinal GPCR signaling","description":"The top GO terms point to GPCR signaling and opsin-mediated signaling (vision-related) as well as visual perception, alongside cardiac-related processes (heart development, cardiac muscle contraction, SA node regulation). This combination suggests a theme of GPCR-driven signaling in both retinal/visual pathways and cardiac tissue. Therefore, a concise label like \"Cardiac and retinal GPCR signaling\" captures the shared functional thread.","confidence":"Medium","size":19,"edges":5,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0035562","count":5},{"id":"GO:0022400","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0060048","count":5}]},{"hash":"1643958113963338868","title":"Dopaminergic Signaling and Oxidative Stress Response","description":"The top GO terms point to dopaminergic synaptic transmission together with detoxification of oxidants and activation of PI3K/AKT signaling, indicating a neuronal module where dopamine signaling intersects with cellular stress response and proteostasis mechanisms. This justifies a label that emphasizes both dopaminergic neurotransmission and oxidative stress-related signaling pathways. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009636","count":5},{"id":"GO:0098869","count":4},{"id":"GO:0051897","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0032435","count":3}]},{"hash":"860700440964350783","title":"Innate Immunity and Cell-Cell Adhesion","description":"The top GO terms cluster around innate immune activation (complement activation, innate immune response, regulation of macrophage and NK/T cell activity) and processes involving cell-cell adhesion and synapse assembly, plus actin cytoskeleton regulation\u2014together pointing to innate defense coordinated through cell contact signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":12},{"id":"GO:0046718","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0090138","count":11},{"id":"GO:0086072","count":11}]},{"hash":"637208995565415986","title":"Host-Pathogen Defense Signaling","description":"Top GO terms cohere around defense against pathogens (defense response to bacterium, cytolysis, viral release from host cell) and pathogen-associated catabolic and signaling processes (peptidoglycan and cell wall catabolism, regulation of signaling via adenylyl cyclase and calcium). The presence of neural-related terms (regulation of sensory perception of pain, locomotory behavior) suggests these proteins may participate in organismal responses to infection that involve the nervous system. Overall, these proteins likely form a cluster centered on host defense and infection-related signaling.","confidence":"Medium","size":19,"edges":65,"triangles":55,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":19},{"id":"GO:0019835","count":19},{"id":"GO:0019076","count":19},{"id":"GO:0009253","count":19},{"id":"GO:0007194","count":19}]},{"hash":"881867806379867994","title":"Dopaminergic Signaling in Neural Development","description":"The cluster is strongly enriched for nervous system\u2013related terms: enteric nervous system development, grooming behavior, neuropeptide signaling, synaptic transmission (dopaminergic), and both positive and negative regulation of dopamine receptor signaling. These point to a cohesive theme of dopamine-mediated neural signaling and neural development. Some terms like saliva secretion and metanephric glomerulus development appear as peripheral associations, but the dominant signal centers on dopaminergic neural communication.","confidence":"High","size":19,"edges":18,"triangles":1,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":19},{"id":"GO:0072224","count":19},{"id":"GO:0060160","count":19},{"id":"GO:0048484","count":19},{"id":"GO:2000458","count":19}]},{"hash":"81150081684329342","title":"Vesicle trafficking and signaling","description":"Top terms cluster around vesicle trafficking and signaling: synaptic vesicle endocytosis, endocytic recycling, Rab signal transduction, GTPase regulation, and basal protein localization, plus nerve growth factor signaling. This suggests a core role in membrane trafficking and receptor-mediated signaling. A few terms relate to keratinocyte differentiation, telomere maintenance, and cytokine production, which may reflect peripheral or context-dependent roles but do not define the main theme.","confidence":"Medium","size":19,"edges":114,"triangles":341,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0038180","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0045618","count":2},{"id":"GO:0048488","count":1},{"id":"GO:0032483","count":1}]},{"hash":"877442779587419937","title":"Excitable-cell signaling and vesicle trafficking","description":"This cluster prominently features terms tied to excitability and neurotransmission: synaptic vesicle budding from presynaptic endocytic zones, and regulation of voltage-gated calcium channel activity, plus regulation of cardiac muscle membrane potential and sensory perception of sound. These point to neuronal and cardiac signaling and vesicle trafficking. The other terms (Golgi retention, ribosome biogenesis, protein homooligomerization) reflect general cellular machinery that supports these processes. Overall, the cluster seems centered on excitability and vesicle trafficking in excitable cells.","confidence":"Medium","size":19,"edges":19,"triangles":2,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0045053","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0051260","count":3},{"id":"GO:1901387","count":2}]},{"hash":"343162896553102277","title":"Steroid biosynthesis and P450 metabolism","description":"The top GO terms cluster around steroid biosynthetic processes (ecdysone, aldosterone, bile acids, brassinosteroids) and associated omega-hydroxylase P450 pathways, indicating a shared theme of steroid hormone production and related oxidative modifications across diverse organisms. Some developmental and stress-related terms appear less central to the core theme but do not override the steroid/metabolic signal.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006697","count":19},{"id":"GO:0097267","count":19},{"id":"GO:0032342","count":19},{"id":"GO:0071615","count":19},{"id":"GO:0006699","count":19}]},{"hash":"1226053841201086423","title":"Epithelial polarity and actin cytoskeleton organization","description":"The top GO terms cluster around Rho signaling, actin cytoskeleton organization, microvillus assembly, and establishment of apical/basal polarity, plus tight junction and centrosome localization, which together point to coordinated control of cell shape, junctions, and polarity in epithelial cells. Additional terms about protein localization to synapse and synaptic plasticity suggest possible overlap with epithelial or sensory epithelia (e.g., hair cells) where cytoskeletal and polarity cues govern specialized junctions and projections. Overall, the cluster seems to reflect a cohesive theme of epithelial polarity coupled with cytoskeletal dynamics and junction formation.","confidence":"High","size":19,"edges":12,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":8},{"id":"GO:0051660","count":7},{"id":"GO:0070830","count":7},{"id":"GO:0035418","count":7},{"id":"GO:0030036","count":6}]},{"hash":"2127519657885789701","title":"Rho GTPase\u2013driven cytoskeleton remodeling","description":"The Top Terms cluster around Rho signaling and GTPase activity (regulation of Rho protein signal transduction, positive regulation of GTPase activity) and downstream cytoskeletal processes such as filopodium assembly and integrin activation, indicating a common theme of actin cytoskeleton remodeling controlled by Rho-family GTPases. Some terms (sterol biosynthesis, ascospore membrane formation, spinal cord development) are less directly related, suggesting broader or multi-function annotations, but the core signal is cohesive enough to justify the label.","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0030259","count":2},{"id":"GO:0033622","count":2},{"id":"GO:0016126","count":2},{"id":"GO:0032120","count":2}]},{"hash":"102660536759923292","title":"TORC1-driven growth and stress responses","description":"The terms cluster around cellular growth and protein synthesis control, notably TORC1 signaling, ribosome biogenesis, and mRNA transport, with supporting roles for serine dephosphorylation and GTPase/cytoskeletal regulation. Additional links to ER-stress\u2013related apoptosis and actin dynamics suggest a broader growth\u2013stress program rather than a single pathway, supporting a label focused on TORC1-driven growth and related stress responses.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070262","count":15},{"id":"GO:0051028","count":15},{"id":"GO:0038202","count":15},{"id":"GO:0043547","count":15},{"id":"GO:0016575","count":14}]},{"hash":"94501923752706766","title":"Stress Response and Detoxification","description":"These proteins cluster around cellular defenses against chemical stress and genome maintenance: responses to toxic substances, xenobiotic metabolism, nucleotide-excision repair, and ROS-related signaling, with transcriptional regulation that can adjust gene expression during stress and immune signaling. While a few terms are broader (growth, nitrogen regulation), the core theme centers on detoxification, stress response, and DNA repair.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006808","count":1},{"id":"GO:0071638","count":1}]},{"hash":"1282012306256661732","title":"Diverse membrane transporters","description":"Based on GO terms, this cluster centers on transmembrane transport of ions, sugars, and xenobiotics, plus a vesicular neurotransmitter loading term. The variety of substrates and the shared function of moving substances across membranes strongly tie the proteins to transporter activity, justifying a label of a transporter-enriched cluster.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":15},{"id":"GO:0071805","count":15},{"id":"GO:0015707","count":14},{"id":"GO:0035435","count":14},{"id":"GO:0035725","count":14}]},{"hash":"1247060371200230144","title":"Metanephric kidney development","description":"This cluster shows multiple GO terms centered on metanephric nephron development (thick ascending limb, ascending limb, distal convoluted tubule) and related cell-matrix adhesion, pointing to kidney organogenesis as the main theme. Additional terms touch on vascular and neural morphogenesis and immune pathways, but the kidney-related terms are most prominent, supporting a label focused on metanephric kidney development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007160","count":5},{"id":"GO:0072233","count":5},{"id":"GO:0072218","count":5},{"id":"GO:0003273","count":5},{"id":"GO:0035912","count":5}]},{"hash":"821428992960191282","title":"Neural development with inflammatory signaling","description":"The protein set shows strong signals for CNS development and connectivity (corticospinal neuron axon guidance, corpus callosum development, positive regulation of synapse assembly) alongside inflammatory/pain-related terms (inflammatory response, IL-18 production, behavioral response to formalin-induced pain), with some broader developmental terms, suggesting a cluster centered on neural development linked with inflammatory signaling.","confidence":"Medium","size":19,"edges":104,"triangles":284,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032741","count":19},{"id":"GO:0072224","count":19},{"id":"GO:0021972","count":19},{"id":"GO:0006954","count":19},{"id":"GO:0061368","count":19}]},{"hash":"776923477205502536","title":"Developmental Morphogenesis and Differentiation","description":"The top GO terms point to morphogenesis and tissue differentiation across multiple organs (comma-shaped body morphogenesis, Malpighian tubule tip cell differentiation, floor plate development, ascending aorta morphogenesis, Notch pathway involvement in heart induction, and osteoblast differentiation regulation), complemented by a broad transcriptional machinery term (RNA polymerase II). While some terms touch on immune response or stress, the dominant signal is developmental morphogenesis and differentiation.","confidence":"Medium","size":19,"edges":164,"triangles":859,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":17},{"id":"GO:0072049","count":13},{"id":"GO:0061382","count":13},{"id":"GO:0072750","count":13},{"id":"GO:0090403","count":13}]},{"hash":"893616497930946690","title":"Insulin-regulated glucose and lipid metabolism","description":"The top GO terms cluster around insulin-dependent glucose handling (positive regulation of glucose import in response to insulin stimulus, regulation of glucose metabolic process, insulin receptor signaling) and lipid regulation (cholesterol homeostasis, PPAR signaling). While there are a few secondary terms related to heart/placenta development and inflammatory response, the dominant pattern reflects metabolic regulation governed by insulin signaling and lipid metabolism pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0001300","count":3},{"id":"GO:0071222","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0010906","count":2}]},{"hash":"1028569216233586843","title":"Immune synapse and cytotoxic regulation","description":"The cluster's top GO terms cluster around immune cell\u2013cell adhesion (homophilic/heterophilic), actin cytoskeleton remodeling linked to adhesion, immune synapse assembly, T cell costimulation, and regulation of cytotoxic lymphocyte activity (degranulation and NK cell cytotoxicity), with supporting signals such as defense against bacteria and IL-4 production. This pattern suggests proteins involved in immune cell contact/communication and control of cytotoxic responses, i.e., immune synapse machinery and cytotoxic regulation.","confidence":"High","size":19,"edges":3,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042742","count":14},{"id":"GO:0007156","count":14},{"id":"GO:0046718","count":14},{"id":"GO:0090138","count":14},{"id":"GO:0043318","count":14}]},{"hash":"340563945535512756","title":"Embryonic organogenesis and tissue differentiation","description":"The top GO terms point to development and differentiation across multiple embryonic tissues\u2014placental/trophoblast differentiation, endocrine organ development, heart-associated EMT, cartilage morphogenesis, and GI epithelium maintenance\u2014plus pattern formation. While there is an element of immune signaling (complement activation), the dominant theme is embryonic tissue specification and organogenesis, making a cohesive label around developmental processes appropriate.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0030277","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0045892","count":2},{"id":"GO:0060972","count":2}]},{"hash":"1736534925290667518","title":"Vertebrate somite and axial skeleton morphogenesis","description":"The top GO terms point to vertebrate embryonic development, especially somite formation/specification, axis and left\u2013right patterning, bone morphogenesis, and Notch signaling in somitogenesis and related pharyngeal structures.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0001503","count":2},{"id":"GO:0007368","count":2},{"id":"GO:0032525","count":2},{"id":"GO:0060349","count":2}]},{"hash":"295214729620523125","title":"Inflammation and Cytokine Signaling in Vascular and Cardiac Development","description":"This cluster centers on inflammatory response and JAK-STAT\u2013mediated signaling, suggesting cytokine-driven communication. The presence of terms about vascular smooth muscle proliferation, ventricular cardiac muscle development, and osteoclast differentiation points to roles in tissue remodeling across vascular and cardiac contexts, with additional links to mitochondria and cytoskeletal organization. The overall theme is inflammation-associated signaling that influences vascular/cardiac development and remodeling, with sparse connectivity among members.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1904706","count":2},{"id":"GO:0046427","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0045672","count":2},{"id":"GO:0072201","count":1}]},{"hash":"1161596228226727042","title":"Embryonic development and transcriptional regulation","description":"This cluster centers on developmental processes (endocrine system development, placenta development, left-right pattern formation, EMT in endocardial cushion formation) together with gene expression control (mRNA splicing via spliceosome, negative regulation of transcription by RNA Polymerase II) and epigenetic modification (C-5 methylation of cytosine). Although there are no edges indicating direct interactions here, the GO terms collectively point to proteins involved in developmental differentiation and RNA processing/epigenetic regulation. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0090116","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1693875897707949603","title":"Embryonic development and morphogenesis","description":"This cluster is dominated by GO terms tied to developmental processes, including left/right pattern formation, multiple forms of tissue morphogenesis (cartilage, hair follicle, palate), and organ development (endocrine system, placenta, heart cushion formation). The assortment across tissues and stages suggests a general developmental/morphogenetic program rather than a single tissue-specific role. The proteins likely function as regulators or effectors of embryogenesis and tissue morphogenesis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":9},{"id":"GO:0035270","count":9},{"id":"GO:0003198","count":9},{"id":"GO:0060806","count":9},{"id":"GO:0060536","count":9}]},{"hash":"1662150449255620174","title":"Vertebrate Development and Morphogenesis","description":"The top GO terms cluster around embryonic development and tissue morphogenesis, including palate formation, left-right patterning, hair follicle morphogenesis, and endocardial cushion EMT, pointing to a common theme of vertebrate organogenesis. Some terms reflect general cellular processes (RNA splicing, transcription regulation, ribosomal export) that appear less central to the theme but do not overshadow the developmental signal.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0031069","count":2}]},{"hash":"1184946406920784343","title":"Embryonic Development and Organogenesis","description":"The top GO terms cluster around developmental processes across multiple tissues\u2014endothelial proliferation, left/right pattern formation, EMT in heart development, cartilage morphogenesis, pancreatic cell development, and placental/embryonic patterning\u2014indicating a broad embryogenesis and organ formation theme. A few terms (DNA transposition, spliceosome-mediated mRNA splicing) appear peripheral, likely reflecting background gene regulation rather than core developmental function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003198","count":1}]},{"hash":"1043256683688778580","title":"Schwann cell function and nerve regeneration","description":"The cluster centers on nervous system development and repair, with terms like somatic motor neuron differentiation, neurofilament cytoskeleton organization, and (negative regulation of) Schwann cell migration/proliferation involved in axon regeneration. Additional terms such as epidermal growth factor receptor signaling and receptor recycling point to cellular signaling and membrane trafficking relevant to Schwann cells and neurons, while lipid biosynthesis terms (ergosterol, ceramide) likely reflect membrane biology in neural cells and ECM-associated processes (collagen biosynthesis). Together these suggest a cohesive theme of peripheral nerve development and repair mediated by Schwann cells and associated neurons.","confidence":"High","size":18,"edges":150,"triangles":769,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006696","count":2},{"id":"GO:0007173","count":2},{"id":"GO:0001881","count":2},{"id":"GO:0046513","count":1},{"id":"GO:0032964","count":1}]},{"hash":"1472618458130888751","title":"Sphingolipid and phospholipid metabolism","description":"Several top GO terms point to lipid biosynthesis and signaling, notably sphingosine and sphinganine-1-phosphate metabolic processes, sphingolipid mediated signaling, phosphatidylglycerol biosynthetic process, and phospholipid dephosphorylation, suggesting a lipid metabolism/signaling focus for this cluster. Some terms (glucose-6-phosphate transport, cellular oxidant detoxification, germ cell repulsion, and obsolete Wnt terms) appear ancillary or contextual rather than central. Overall, the common thread is coordinated lipid metabolism and membrane signaling functions.","confidence":"High","size":18,"edges":17,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006655","count":3},{"id":"GO:0035233","count":3},{"id":"GO:0044329","count":3},{"id":"GO:1902068","count":3},{"id":"GO:0006670","count":3}]},{"hash":"756818072658187298","title":"Membrane trafficking and lipid metabolism with stress response","description":"The cluster highlights ER-to-Golgi vesicle transport, GPI anchor biosynthesis, and cholesterol biosynthetic processes, pointing to membrane protein processing and lipid metabolism. It also includes autophagy regulation and p53-linked apoptotic signaling, suggesting coordinated cellular stress responses. While visual perception and photoreceptor maintenance appear among terms, the core theme most consistently ties to membrane trafficking and lipid biology with stress-response pathways.","confidence":"Medium","size":18,"edges":107,"triangles":289,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0006695","count":2},{"id":"GO:0030097","count":2},{"id":"GO:0042771","count":2}]},{"hash":"538453014758572568","title":"Neurovascular signaling and angiogenesis","description":"The terms cluster around neural signaling (positive regulation of nerve impulse transmission, neuron survival), vascular development (angiogenesis), and extracellular/tissue remodeling processes (cell-matrix adhesion, protein localization to the cell surface) with accompanying signaling pathways (ERK cascade) and metabolic/adipose-related regulation. This suggests a coordinated neurovascular remodeling program rather than a single isolated function, hence the label focusing on neurovascular signaling and angiogenesis. ","confidence":"High","size":18,"edges":57,"triangles":66,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045668","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0070352","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0010765","count":2}]},{"hash":"2034043099641415973","title":"Cardiac sarcomere organization and cAMP signaling","description":"This cluster centers on cardiac muscle structure and growth, with enrichment for sarcomere organization and cardiac muscle cell proliferation. It also shows regulation of cAMP signaling (negative regulation of PKA activity and cellular response to cAMP), suggesting coordinated signaling control of cardiac function. A transcriptional angle is present (DNA-templated transcription), indicating accompanying gene expression programs. While a few terms are more general metabolic/regulatory, the dominant themes point to cardiac sarcomere assembly and cAMP-driven regulation.","confidence":"High","size":18,"edges":126,"triangles":481,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000480","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0046827","count":7},{"id":"GO:0019346","count":7},{"id":"GO:0060038","count":5}]},{"hash":"2164640139097885169","title":"Neural development and Wnt signaling","description":"This cluster is dominated by nervous system development and dendritic spine-related terms (GO:0007399, GO:0060999) and neuroblast proliferation, along with Wnt signalosome assembly (GO:1904887) and small GTPase signaling (GO:0007264), suggesting a coherent theme of neural development and associated signaling pathways that govern neuron formation, synapse maturation, and neurogenesis. Some vascular/contractile terms appear, reflecting broader developmental signaling interconnected with neural processes.","confidence":"High","size":18,"edges":119,"triangles":401,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":18},{"id":"GO:0007399","count":18},{"id":"GO:0034629","count":18},{"id":"GO:0046909","count":18},{"id":"GO:0007264","count":18}]},{"hash":"1380010114132987111","title":"GPCR-driven proliferation and wound response","description":"The top GO terms cluster around G protein-coupled receptor signaling and cell proliferation related to neural and skin contexts (neuroblast proliferation, hair follicle cell proliferation, wound healing). Additional terms touch on intracellular trafficking and metabolism, but the strongest signal is GPCR signaling linked to growth and tissue repair, justifying a label focused on GPCR-mediated proliferation and healing.","confidence":"Medium","size":18,"edges":150,"triangles":771,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902692","count":18},{"id":"GO:0044319","count":18},{"id":"GO:0034379","count":18},{"id":"GO:0033028","count":18},{"id":"GO:0035646","count":18}]},{"hash":"1469345263263921735","title":"Membrane signaling and ion transport","description":"This cluster centers on membrane-related functions: purinergic receptor signaling, iodide and chloride transport, calcium-activated phospholipid scrambling, bleb assembly, and processes related to phagocytosis, coagulation, and endothelial cell behavior. While diverse, the shared theme is cellular membrane signaling and transport activities that influence immune, vascular, and secretory responses. Confidence: Medium.","confidence":"","size":18,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060100","count":3},{"id":"GO:0035590","count":3},{"id":"GO:0015705","count":3},{"id":"GO:0032060","count":3},{"id":"GO:0007596","count":3}]},{"hash":"2272327612507489170","title":"Axonal transport and neuronal cytoskeleton","description":"The top GO terms consistently indicate neuronal components and cytoskeletal processes: retrograde axonal transport, microtubule polarity establishment, neurofilament bundle assembly, and peripheral nerve axonogenesis. Together these point to proteins coordinating axon structure and trafficking. Some terms (lens fiber development, fast-twitch muscle contraction) reflect shared cytoskeletal components, but the dominant theme is neuronal cytoskeleton and axonal transport.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0031443","count":18},{"id":"GO:0043000","count":18},{"id":"GO:0090343","count":18},{"id":"GO:0035105","count":18},{"id":"GO:1904714","count":18}]},{"hash":"1332337126761058210","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000466","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0000472","count":4},{"id":"GO:0048026","count":3}]},{"hash":"841457614019837435","title":"Centromere assembly and mitotic spindle formation","description":"This cluster is dominated by centromere-related chromatin assembly (CENP-A), mitotic spindle assembly, and cell division terms, pointing to a core function in chromosome segregation during mitosis. Other terms such as ribosome biogenesis or ER-Golgi transport are likely background processes and do not override the mitotic theme.","confidence":"High","size":18,"edges":110,"triangles":321,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":13},{"id":"GO:0061641","count":13},{"id":"GO:0051260","count":13},{"id":"GO:0030433","count":13},{"id":"GO:0051013","count":13}]},{"hash":"2133498636699874327","title":"Hypoxia-responsive transcription and cell proliferation","description":"This cluster is enriched for terms related to responding to low oxygen, transcriptional regulation, and signaling (including TGF-beta), along with chromatin remodeling and various facets of cell proliferation and tissue development. The common thread appears to be environmental or signaling cues driving transcriptional programs that promote cell growth, with some support from developmental context like seminiferous tubule development. Therefore, a label emphasizing hypoxia-driven transcription and proliferation best captures the cluster\u2019s core theme.","confidence":"Medium","size":18,"edges":126,"triangles":526,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071456","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0071560","count":6},{"id":"GO:0016575","count":6},{"id":"GO:0072520","count":6}]},{"hash":"1336674229745780496","title":"Ubiquitin-Proteasome Regulation and Signaling","description":"Most terms center on ubiquitin-proteasome system components and regulation (SCF-dependent ubiquitination, proteasomal degradation, and deubiquitination), with additional indications of signaling pathway involvement (canonical Wnt, planar cell polarity, and TNF signaling) and stress responses. This points to a cluster of proteins focused on proteostasis and its links to signaling networks. Some terms are obsolete, but the core theme remains proteolysis regulation and signaling crosstalk.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051436","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0033209","count":2},{"id":"GO:0010499","count":2},{"id":"GO:0060071","count":2}]},{"hash":"203286992782210664","title":"Cartilage and collagen ECM formation","description":"The cluster centers on cartilage condensation, intramembranous ossification, and collagen-related processes (biosynthesis and fibril organization), with additional links to skin morphogenesis. Together these terms point to connective tissue development and extracellular matrix collagen assembly, justifying a label focused on cartilage/ECM formation. Some terms are peripheral (kidney, immune regulation), but the core theme remains skeletal/connective tissue and collagen ECM. ","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001502","count":4},{"id":"GO:0001957","count":4},{"id":"GO:0032964","count":3},{"id":"GO:0045715","count":3},{"id":"GO:1901492","count":3}]},{"hash":"1758598902943879067","title":"Cell Cycle and Chromatin Regulation","description":"Dominant signals are cell division, CENP-A containing chromatin assembly, and DNA-templated transcription, with supporting links to ribosome biogenesis and microtubule dynamics, indicating a cluster of proteins involved in cell-cycle progression and chromatin organization. A few terms related to trafficking and ubiquitin pathways are present but appear peripheral.","confidence":"High","size":18,"edges":21,"triangles":4,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":16},{"id":"GO:0061641","count":16},{"id":"GO:0006351","count":16},{"id":"GO:0051260","count":16},{"id":"GO:0030433","count":16}]},{"hash":"644409917915241234","title":"Brain development and apoptosis regulation","description":"This cluster prominently features neural development terms (cerebral cortex development, corpus callosum development, regulation of axon regeneration) alongside apoptosis/stress signaling (intrinsic apoptotic signaling in ER stress, negative regulation of JNK, negative regulation of anoikis). While there are other diverse terms (e.g., meiotic DNA repair, galactose-responsive transcription), the strongest coherent theme is brain development coupled with apoptosis and stress response pathways, suggesting a module involved in neural development with programs for cell fate and survival under stress.","confidence":"Medium","size":18,"edges":89,"triangles":249,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":17},{"id":"GO:0070059","count":17},{"id":"GO:0046329","count":17},{"id":"GO:0072428","count":17},{"id":"GO:0021987","count":17}]},{"hash":"1426573790581539633","title":"DNA damage repair and stress response","description":"The top GO terms point to base-excision repair, DNA recombination, and transcription regulation, with associated apoptosis and xenobiotic response, suggesting a core theme of genome maintenance under stress and transcriptional control during damage response. Some terms are obsolete or less cohesive (aging, demethylation), while a few entries like corneocyte development are peripheral, but the dominant signal supports DNA repair and stress signaling as the cluster\u2019s function.","confidence":"High","size":18,"edges":99,"triangles":257,"max_degree":17,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":5},{"id":"GO:0045944","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0007568","count":4}]},{"hash":"618262689067455973","title":"Neural development and synapse formation","description":"Many top GO terms cluster around neural development and synaptic assembly: dendritic spine morphogenesis, positive regulation of synapse assembly, optic nerve morphogenesis, corpus callosum development, and fasciculation of motor neuron axons, supported by PI3K-AKT signaling. While a few terms touch on broader embryonic development (axial mesoderm formation, heart development) the dominant theme is neural connectivity and morphogenesis.","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071372","count":6},{"id":"GO:0060997","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0022038","count":6},{"id":"GO:0021631","count":6}]},{"hash":"1462171927381175748","title":"Nervous System Development and Signaling","description":"The top GO terms are dominated by nervous system-related processes (sensory perception of sound, spinal cord development, regulation of myelination) and signaling pathways (PI3K/AKT, GPCR signaling), suggesting a cohesive theme of neural development and neural signal transduction. Some terms like cardiac contraction or germ cell development are peripheral annotations, but the core cluster points to neural development and myelination. ","confidence":"High","size":18,"edges":25,"triangles":12,"max_degree":8,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007605","count":9},{"id":"GO:0007205","count":8},{"id":"GO:0051262","count":7},{"id":"GO:0014065","count":6},{"id":"GO:0043491","count":6}]},{"hash":"1261404535367424405","title":"Ubiquitin-Proteasome\u2013Mediated Proteolysis and Cell Cycle","description":"This cluster is dominated by ubiquitination and degradation pathways: autoubiquitination, K11-linked ubiquitination, SCF- and APC/C-dependent proteolysis, and protein neddylation, all pointing to regulated proteasomal degradation. ER-associated degradation (ERAD) and proteasomal catabolism further support a protein quality-control module that interfaces with cell-cycle control and stress responses (including ER stress\u2013induced apoptosis). A single outlier term on DNA repair is less connected but does not override the main theme.","confidence":"High","size":18,"edges":77,"triangles":152,"max_degree":17,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070911","count":18},{"id":"GO:0051865","count":17},{"id":"GO:0030433","count":17},{"id":"GO:0051301","count":17},{"id":"GO:0031145","count":17}]},{"hash":"1689682323480260485","title":"Dendritic spine remodeling and ciliary signaling","description":"The top terms cluster around spine morphogenesis, cytoskeletal organization (microtubules and actin), and receptor localization to non-motile cilia, with associated odorant response and ERK pathway regulation, indicating roles in neuronal spine remodeling and ciliary signaling.","confidence":"High","size":18,"edges":9,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":2},{"id":"GO:0051289","count":2},{"id":"GO:0000226","count":2},{"id":"GO:1990834","count":2},{"id":"GO:0097500","count":2}]},{"hash":"1846206465042417186","title":"Immune Regulation and Protein Turnover","description":"Based on the top GO terms, this cluster centers on immune system processes (negative regulation of IL-1\u03b2 production, MHC class I biosynthesis, V(D)J recombination, chemokine production) and protein homeostasis pathways (ubiquitination, autoubiquitination, autophagy, polyubiquitination). The combination suggests a cohesive theme where immune signaling is modulated through ubiquitin-mediated turnover and autophagic pathways, justifying a label focused on immune regulation and protein turnover.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0050713","count":18},{"id":"GO:0045345","count":18},{"id":"GO:0051865","count":18},{"id":"GO:2000637","count":18},{"id":"GO:0090073","count":18}]},{"hash":"2290910816248385578","title":"Cardiac development and Wnt-regulated signaling","description":"The dominant themes are heart development and Wnt-mediated signaling, with accompanying roles in transcriptional regulation and cell migration. Although there is some epithelial differentiation signal, the strongest signals point to cardiac morphogenesis and its regulatory pathways.","confidence":"High","size":18,"edges":21,"triangles":3,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0043547","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0033138","count":5}]},{"hash":"1156132482780243158","title":"Ureteric Bud and Kidney Morphogenesis","description":"Most top GO terms concentrate on ureteric bud morphogenesis, development, and formation, pointing to kidney development and its branching processes as the central theme. Additional terms touch on mesenchymal-to-epithelial transitions and other organ morphogenesis events (e.g., AV valve morphogenesis, chorio-allantoic fusion), suggesting a broader, yet kidney-focused morphogenetic context. This coherence supports labeling the cluster as kidney/ureteric bud morphogenesis.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"wound healing","top_go_terms":[{"id":"GO:0090190","count":15},{"id":"GO:0003181","count":15},{"id":"GO:0003337","count":15},{"id":"GO:0001657","count":15},{"id":"GO:0002062","count":15}]},{"hash":"1696229906727373197","title":"Developmental signaling and neural growth","description":"This cluster is enriched for terms tied to developmental processes (bone development, axonogenesis, globus pallidus development) and signaling pathways (phosphatidylinositol-mediated signaling, regulation of protein kinase activity). While there are some miscellaneous terms (autophagy regulation, cell Cycle), the dominant theme is development coupled with signaling that governs growth and neural patterning, with several brain-related terms suggesting a leaning toward neural development. Given the mix, the label reflects a core emphasis on developmental signaling and neural growth rather than a single organ or pathway.","confidence":"Medium","size":18,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":2},{"id":"GO:0032120","count":2},{"id":"GO:0048015","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0016239","count":2}]},{"hash":"1819090177179343280","title":"Growth, differentiation, and apoptosis signaling","description":"Cells in this cluster are connected through pathways that regulate growth/proliferation (Wnt, Hippo, cardiac proliferation), differentiation (keratinocytes), and survival/apoptosis (apoptotic processes, glial apoptotic regulation), with additional links to neuronal signaling (glutamatergic transmission and synaptic plasticity). The common thread is signaling networks that govern cell fate decisions across multiple tissues, rather than a single tissue-specific function. ","confidence":"Medium","size":18,"edges":101,"triangles":282,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060044","count":15},{"id":"GO:0090263","count":15},{"id":"GO:0030216","count":15},{"id":"GO:0006915","count":15},{"id":"GO:0035329","count":15}]},{"hash":"739626654545214534","title":"Planar cell polarity and tissue morphogenesis","description":"The cluster\u2019s top GO terms strongly converge on planar cell polarity (establishment of planar polarity, planar orientation), paired with cell adhesion and morphogenetic processes (e.g., lung branching morphogenesis, hair orientation, neuronal guidance), suggesting a core theme around PCP-guided tissue organization during development.","confidence":"High","size":18,"edges":53,"triangles":83,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007213","count":14},{"id":"GO:0043113","count":14},{"id":"GO:0007157","count":14},{"id":"GO:0036514","count":13},{"id":"GO:0048105","count":13}]},{"hash":"1033001590063563053","title":"Glycosaminoglycan biosynthesis and zona pellucida interactions","description":"This cluster is centered on extracellular matrix components, notably hyaluronan and keratan sulfate proteoglycan biosynthesis, pointing to GAG production. It also includes processes related to sperm binding and penetration of the zona pellucida, suggesting fertilization-associated ECM interactions. Additional terms about epithelial cell migration/proliferation in wound healing align with ECM remodeling, though some terms (infection structure formation, cerebellar development) are more divergent. Overall, the core theme appears to be glycosaminoglycan biosynthesis and fertilization-associated matrix interactions.","confidence":"Medium","size":18,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030213","count":3},{"id":"GO:0018146","count":3},{"id":"GO:0060054","count":3},{"id":"GO:0007341","count":3},{"id":"GO:0010634","count":3}]},{"hash":"2185601924124032095","title":"Actin Cytoskeleton Remodeling in Development and Immunity","description":"This cluster centers on actin-driven processes: actin cytoskeleton organization, lamellipodium assembly, and cell migration, indicating a core theme of cytoskeletal remodeling facilitating movement. The inclusion of broader signaling terms (insulin receptor signaling, Ras regulation) alongside developmental (heart development) and immune-related processes (B cell affinity maturation, NK T cell differentiation, IL-7 response) suggests the proteins participate in cytoskeleton-assisted signaling and migration across developing tissues and immune cell contexts. Overall, the shared motif appears to be actin-driven remodeling that enables migration and signaling in development and immunity.","confidence":"Medium","size":18,"edges":14,"triangles":6,"max_degree":6,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030036","count":9},{"id":"GO:0008286","count":9},{"id":"GO:0016477","count":9},{"id":"GO:0007507","count":8},{"id":"GO:0098761","count":8}]},{"hash":"1988958123896429811","title":"Acetylation-Related Biosynthesis Cluster","description":"The GO terms are heavily weighted toward acetylation-related processes, including N-terminal acetylation, histone acetylation, and various protein acetylation/propionylation events, suggesting a cluster of proteins involved in acetylation-based modification. There are also several biosynthetic processes (L-arginine, glucosamine, mycothiol) that imply metabolic roles tied to these modifications. A few terms like angiogenesis and melatonin biosynthesis appear as outliers, likely annotation noise, but the core theme remains acetylation-associated protein modification with linked biosynthetic activities.","confidence":"Medium","size":18,"edges":137,"triangles":654,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":16},{"id":"GO:0030187","count":15},{"id":"GO:0006041","count":15},{"id":"GO:0001525","count":15},{"id":"GO:0017198","count":15}]},{"hash":"1730388912569202127","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":13,"triangles":2,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000122","count":3}]},{"hash":"972205434899757483","title":"Spinal motor neuron development and axon guidance","description":"This cluster centers on neural development in the spinal cord, with several terms pointing to motor neuron axon pathfinding, medial motor column differentiation, ventral interneuron specification, and ectoderm formation. Additional terms about cell-cell junctions and adhesion-related processes fit the developmental context, though there are a couple of non-neural terms present. Overall, the dominant signal is spinal cord neural differentiation and axon guidance, justifying the label.","confidence":"High","size":18,"edges":18,"triangles":7,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":11},{"id":"GO:0045216","count":10},{"id":"GO:0021526","count":10},{"id":"GO:0035584","count":10},{"id":"GO:0097067","count":10}]},{"hash":"377453876215500531","title":"EMT and Cytoskeletal Remodeling","description":"The cluster centers on epithelial-to-mesenchymal transition, lamellipodium and actin organization, and sarcomere structure, with EGFR signaling and NFAT pathways that connect cytoskeletal dynamics to developmental and cardiac contexts. Some terms like sulfur oxidation appear peripheral, but the core theme ties to cell movement and muscle-related remodeling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001837","count":3},{"id":"GO:0007173","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0051764","count":3}]},{"hash":"1219759158282834372","title":"Regulators of TGF-\u03b2/BMP signaling","description":"Top GO terms emphasize negative regulation of TGF-\u03b2 receptor signaling and BMP signaling, and negative regulation of SMAD complex assembly, suggesting these proteins act as modulators of TGF-\u03b2/BMP pathways. Additional terms about peptidyl-threonine dephosphorylation and nuclear export imply broader regulatory functions, possibly coordinating signal transduction with cellular trafficking and localization.","confidence":"Medium","size":18,"edges":148,"triangles":738,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0042347","count":12},{"id":"GO:0010991","count":12},{"id":"GO:0030514","count":12},{"id":"GO:0061191","count":12},{"id":"GO:0000173","count":12}]},{"hash":"1162219347227838340","title":"Coagulation and vascular remodeling","description":"The cluster is enriched for blood coagulation and fibrinolysis terms, along with negative regulation of angiogenesis and cell-matrix adhesion, suggesting roles in hemostasis and ECM-driven vascular remodeling. Occasional signals related to BMP-based skeletal development imply shared signaling crosstalk with bone formation pathways. Together these terms point to a function cluster centered on coagulation plus vascular/ECM biology.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:0007160","count":5},{"id":"GO:0051006","count":5},{"id":"GO:0030514","count":4},{"id":"GO:0016525","count":4}]},{"hash":"940839594313008064","title":"Hematopoietic lineage differentiation and inflammation","description":"The prominent GO terms indicate differentiation of hematopoietic lineages (myeloid dendritic cells, erythrocytes, lymphoid progenitors, megakaryocytes) and regulation of cell fate commitment, accompanied by inflammatory response. Despite one obsolete BMP signaling term, the shared theme is blood/immune cell lineage specification and related inflammatory signaling, justifying a label focused on hematopoietic differentiation and inflammation.","confidence":"High","size":18,"edges":31,"triangles":15,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043011","count":15},{"id":"GO:0010455","count":15},{"id":"GO:0060803","count":15},{"id":"GO:0030218","count":15},{"id":"GO:0033600","count":15}]},{"hash":"1815195058381076953","title":"Multi-tissue organogenesis","description":"This cluster centers on developmental processes across multiple organs (eye, brain, kidney, thymus, pituitary, gonads, tooth, lung), suggesting a general organogenesis program rather than a tissue-specific pathway.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":3},{"id":"GO:0001658","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0048538","count":2},{"id":"GO:0008584","count":2}]},{"hash":"33056684244892643","title":"Nuclear import and transcription regulation","description":"The top GO terms point to nuclear processes: import of NLS-bearing proteins into the nucleus and regulation of DNA-templated transcription. Additional terms about regulation of cell shape and xenobiotic response can intersect with nuclear signaling and transcriptional control, suggesting a cohesive theme of nuclear transport linked to gene expression regulation. Some neuronal- or tissue-related terms appear incidental rather than core drivers of the cluster, so the central pattern is nuclear import and transcriptional regulation. ","confidence":"Medium","size":18,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0008360","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0098907","count":2}]},{"hash":"354469151858841068","title":"Nuclear RNA processing and transcription regulation","description":"The top GO terms cluster around nuclear processes: mRNA splicing via spliceosome, ribosomal subunit export from the nucleus, and regulation of transcription by RNA polymerase II, with additional hints of chromatin modulation and DNA replication initiation. Although there are some germline and behavioral terms, the dominant theme is nuclear gene expression control and RNA processing, suggesting a cohesive role in nuclear regulation of gene expression across the cluster.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0032298","count":2},{"id":"GO:0000055","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0045071","count":1}]},{"hash":"1148828702248771126","title":"Skeletal muscle development and ubiquitin regulation","description":"The top GO terms strongly point to skeletal muscle biology, with sarcomere organization, skeletal muscle fiber development, and skeletal muscle tissue development indicating a core muscle-related function. The prominent ubiquitin-dependent protein catabolic process and negative regulation of protein ubiquitination suggest regulated protein turnover, a key aspect of muscle remodeling. While there are additional terms related to circadian rhythm and immune signaling that could reflect broader roles or dataset noise, the dominant theme centers on muscle development and ubiquitin-mediated regulation.","confidence":"Medium","size":18,"edges":15,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0042752","count":14},{"id":"GO:0051260","count":12},{"id":"GO:0045214","count":11},{"id":"GO:0031397","count":11}]},{"hash":"1227459156320920935","title":"Neural development and stress response","description":"The terms cluster around brain development (cerebral cortex and corpus callosum development, axon regeneration) and neuronal survival under stress (ER-stress\u2013triggered apoptosis, JNK regulation, and anoikis inhibition), with supporting roles in DNA damage signaling. This suggests a neural development and stress-response theme.","confidence":"High","size":18,"edges":14,"triangles":2,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":18},{"id":"GO:0070059","count":18},{"id":"GO:0046329","count":18},{"id":"GO:0072428","count":18},{"id":"GO:0021987","count":18}]},{"hash":"1926059238919574255","title":"Endomembrane trafficking and cytoskeleton dynamics","description":"The top GO terms point to endomembrane transport processes (endosome- to endosome/lysosome, Golgi to plasma membrane, intralumenal vesicle formation) and microtubule/cytoskeleton organization, suggesting a focus on intracellular trafficking and cytoskeletal regulation. While a few terms touch on ubiquitination, GTPase regulation, mitochondrial fission, and cell cycle, these appear as supporting or broader context rather than defining the cluster. Overall, the shared theme is vesicular transport within the cell coupled with cytoskeletal dynamics, making this a coherent group with a trafficking-cytoskeleton signature.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045022","count":2},{"id":"GO:0070676","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0090141","count":2},{"id":"GO:0000278","count":2}]},{"hash":"578925135089622486","title":"Glycosphingolipid and glycoprotein glycosylation","description":"The top GO terms point to glycosphingolipid and glycoprotein sugar modification paths, including glycosylceramide metabolism, ganglioside biosynthesis, N-linked glycosylation, and protein sialylation. While a few terms mention pollen or olfactory development, those likely reflect broader roles of cell-surface glycans in growth and signaling. Overall, the cluster appears driven by glycosylation and glycan biosynthesis pathways. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006677","count":2},{"id":"GO:0009311","count":2},{"id":"GO:0001574","count":2},{"id":"GO:0009860","count":2},{"id":"GO:0021628","count":2}]},{"hash":"1307244421991788435","title":"N-terminal and histone acetylation","description":"This cluster is dominated by GO terms referencing acetylation: N-terminal protein amino acid acetylation and related N-terminal acetylation terms, as well as histone H4 acetylation. These recurring motifs suggest the proteins collectively participate in acetylation-dependent regulation, particularly modifications at protein N-termini and chromatin-associated histones, making acetylation the core unifying function despite some heterogeneous metabolic or developmental terms appearing among the top terms.","confidence":"High","size":18,"edges":60,"triangles":138,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006474","count":11},{"id":"GO:0030435","count":11},{"id":"GO:0030187","count":11},{"id":"GO:0001525","count":11},{"id":"GO:0006041","count":11}]},{"hash":"973043490624994568","title":"Membrane Transporters","description":"The cluster is dominated by GO terms for transmembrane transport of diverse substrates (ions like K+, Na+, phosphate, nitrite; sugars like galactose and fucose; sialic acid and xenobiotics) and a vesicular neurotransmitter loading term, pointing to a cohesive theme of membrane transport activity across substrates and contexts.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":13},{"id":"GO:0015739","count":11},{"id":"GO:0015707","count":11},{"id":"GO:0035435","count":11},{"id":"GO:0035725","count":11}]},{"hash":"746721952467323534","title":"Olfactory and neural development","description":"This cluster\u2019s top GO terms center on olfactory nerve formation, olfactory placode morphogenesis, neurogenesis, and nervous system development, with supporting terms like axon guidance and Roundabout signaling, indicating a cohesive role in the development and wiring of the nervous/olfactory system during embryogenesis.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021628","count":4},{"id":"GO:0071699","count":4},{"id":"GO:0022008","count":4},{"id":"GO:0007399","count":4},{"id":"GO:1905065","count":4}]},{"hash":"1859993793016739807","title":"LPS and Capsule Polysaccharide Biosynthesis","description":"The top GO terms cluster around biosynthesis of cell-surface glycans and exopolysaccharides, including O antigen (LPS) biosynthesis, colanic acid (capsule) biosynthesis, and related sugar donor pathways (dTDP-rhamnose, GDP-mannose, galactose metabolism). This cohesive theme points to production of surface polysaccharides in bacteria. Some plant-specific biosynthesis terms appear (anthocyanin, phenylpropanoid) but are unlikely to reflect the core cluster function; the dominant signal is bacterial glycan biosynthesis. ","confidence":"High","size":18,"edges":112,"triangles":392,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":17},{"id":"GO:0042619","count":15},{"id":"GO:0009718","count":15},{"id":"GO:0009699","count":14},{"id":"GO:0006012","count":14}]},{"hash":"543998798463281376","title":"Glutathione-dependent detox and amino acid catabolism","description":"Most top GO terms are centered on glutathione metabolism and catabolic breakdown of amino acids (phenylalanine, tyrosine) and xenobiotics, including methylglyoxal detox via glutathione-related pathways. A few terms (transcription regulation by RNA polymerase II, antibiotic response) are less directly tied, but the dominant theme is detoxification and amino acid catabolism associated with the glutathione system.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006749","count":4},{"id":"GO:0006559","count":4},{"id":"GO:0042178","count":4},{"id":"GO:0019243","count":4},{"id":"GO:0055114","count":4}]},{"hash":"718451565727826364","title":"Cardiac Development and Conduction","description":"This cluster is dominated by GO terms related to heart development and cardiac electrophysiology, including heart development, SA node action potential, and regulation of ventricular/atrial membrane depolarization/repolarization, indicating a functional theme around cardiac development and conduction. A few terms (kidney development, myelination, defense response to bacterium, bitter taste, and hearing-related detection) are present but appear to be peripheral annotations rather than core drivers of the cluster\u2019s function. Overall, the cardiac-related terms best explain the cluster\u2019s shared biology.","confidence":"Medium","size":18,"edges":3,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0042552","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0086091","count":5},{"id":"GO:0050910","count":5}]},{"hash":"301990773194065862","title":"Lysosome-autophagy trafficking and organelle homeostasis","description":"This cluster centers on lysosomal processes (lysosomal protein catabolic process, autophagosome maturation), Golgi-to-lysosome transport, and microtubule-based organelle transport, suggesting a shared role in lysosome-dependent degradation and intracellular trafficking, i.e., maintenance of cellular homeostasis via autophagy-lysosome pathways.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050821","count":3},{"id":"GO:0043123","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0046716","count":2},{"id":"GO:0097352","count":2}]},{"hash":"675982992201377009","title":"Nucleotide Metabolism and mtDNA Replication","description":"The top GO terms are dominated by nucleotide-related processes (nucleobase interconversion, CDP/dCDP biosynthesis) and mitochondrial DNA replication, suggesting a core theme around nucleotide metabolism coupled with mitochondrial genome maintenance. The other terms are more diverse (lipid transport, development), making the main cohesive signal those nucleotide and mtDNA functions.","confidence":"Medium","size":18,"edges":47,"triangles":40,"max_degree":9,"top_function":"renal system process","top_go_terms":[{"id":"GO:0015949","count":3},{"id":"GO:0006264","count":3},{"id":"GO:1902254","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0046704","count":3}]},{"hash":"1971523536227104865","title":"Cardiac and neural development","description":"The top GO terms cluster around embryonic development of heart structures (endocardial cushion EMT, mesoderm formation, cardiac muscle proliferation) and brain/ventricular formation (midbrain development, third and fourth ventricle development), suggesting proteins involved in cardiovascular and neural development. A few terms relate to general mRNA processing, but they don\u2019t outweigh the developmental theme. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0003198","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0051571","count":2}]},{"hash":"1729522086481420524","title":"Unknown","description":"The top GO terms span many unrelated biological areas (neuronal vesicle trafficking and endocytosis; spermatid and retina development; glucocorticoid response; fear behavior; glycosylation, apoptosis, and immunoglobulin production), showing no single cohesive function or pathway linking the proteins. With no edges or clear common theme, a specific label cannot be confidently assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000809","count":2},{"id":"GO:2000302","count":2},{"id":"GO:0048515","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0060041","count":2}]},{"hash":"389182123314074020","title":"Synapse morphogenesis and auditory system development","description":"The top GO terms converge on neuronal synapse formation/organization (dendritic spine morphogenesis, protein localization to synapse, synapse organization) and auditory system processes (cochlea morphogenesis, sensory perception of sound, vocalization behavior), with supporting Rho and JNK signaling roles in neuronal morphology. This suggests a coherent cluster centered on synapse development coupled with auditory system functions.","confidence":"High","size":18,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":5},{"id":"GO:0035418","count":5},{"id":"GO:0007605","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007266","count":4}]},{"hash":"556956689500793400","title":"Wnt signaling and bone development","description":"This cluster's top terms include canonical Wnt signaling and bone development, suggesting a shared role in Wnt-regulated skeletal development. Other terms (NF-kappaB/NOD2 signaling, inflammatory regulation) and sporulation-related terms appear less coherent with the main theme and may reflect annotation noise, but the core connection is Wnt-driven development in bone.","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060070","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0007129","count":2},{"id":"GO:0032120","count":2},{"id":"GO:1990108","count":1}]},{"hash":"1183496280989338718","title":"Mitochondrial Autophagy and Apoptosis Regulation","description":"The top GO terms are dominated by autophagy-related processes, especially macroautophagy and autophagy of mitochondrion, plus mitochondrial outer membrane permeabilization and mitochondrial fission/apoptotic signaling, indicating a cohesive theme around mitochondrial quality control and programmed cell death. Some developmental or immune-related terms appear less central to the core function of the cluster, supporting a primary focus on mitochondrial autophagy and apoptosis regulation.","confidence":"High","size":18,"edges":11,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016236","count":3},{"id":"GO:0000422","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0060612","count":2},{"id":"GO:0016311","count":2}]},{"hash":"1598962464372917964","title":"Proton Motive Force and Ion Transport","description":"The dominant GO terms point to membrane energetics and ion movement, including proton transmembrane transport, proton motive force-driven ATP synthesis, vacuolar acidification, and sodium ion transport. These collectively suggest a core theme of energy production tied to proton gradients and membrane transport, even though some terms like type III secretion, angiogenesis, and transcription regulation appear as peripheral annotations. ","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006626","count":7},{"id":"GO:0007035","count":6},{"id":"GO:0042777","count":6},{"id":"GO:0015991","count":6},{"id":"GO:0006814","count":6}]},{"hash":"2082029240207839615","title":"Rho/Rac/Rap GTPase Signaling","description":"Most frequent GO terms center on small GTPases (Rap, Rac, Rho) and their regulation/activation, implying a cluster defined by GTPase-mediated signal transduction. Related pathways include GPCR-mediated cAMP signaling and receptor tyrosine kinase pathways (e.g., insulin-like growth factor signaling). Some terms touch on secretory granule localization and glucose transport, likely linking signaling to trafficking and metabolism. Even without network edges, the common theme is GTPase-driven signal transduction across these proteins.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032486","count":4},{"id":"GO:0090630","count":4},{"id":"GO:2000973","count":4},{"id":"GO:0048009","count":4},{"id":"GO:0035021","count":4}]},{"hash":"1994779151215933339","title":"RNA capping and guanine-N7 methylation","description":"This cluster is dominated by RNA capping and guanine-N7 methylation terms (GO:0006370 and GO:0036265), indicating proteins involved in mRNA maturation via cap formation. The strong presence of these terms suggests a cohesive RNA processing theme, with other terms like epinephrine biosynthesis, organ regeneration, and xenobiotic response likely representing secondary roles or annotation noise. Therefore, the label reflects a cohesive RNA capping/processing cluster.","confidence":"High","size":18,"edges":150,"triangles":769,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0010243","count":18},{"id":"GO:0036265","count":18},{"id":"GO:0006370","count":18},{"id":"GO:0042418","count":18},{"id":"GO:0031100","count":18}]},{"hash":"441320977256693325","title":"RNA and protein methylation","description":"Driven by multiple methylation-related GO terms (rRNA methylation; N-terminal peptidyl-glycine methylation; peptidyl-lysine dimethylation/trimethylation) and links to chromatin formation, suggesting a cluster of methyltransferases involved in RNA/protein methylation and epigenetic regulation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":1},{"id":"GO:0018013","count":1},{"id":"GO:0018027","count":1},{"id":"GO:0018023","count":1},{"id":"GO:0000183","count":1}]},{"hash":"549527123329210403","title":"Rho GTPase\u2013driven actin cytoskeleton remodeling","description":"The top GO terms cluster around actin cytoskeleton organization and Rho GTPase signaling (activation of GTPase activity, negative regulation of Rho signaling, actin organization), suggesting proteins that regulate cytoskeletal dynamics via Rho-family GTPases. Some terms pertain to tissue-specific structures (lens morphogenesis, sensory perception of sound), which can reflect specialized cytoskeletal architectures. Overall, the cluster appears to group proteins involved in cytoskeletal regulation and related trafficking.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0090630","count":4},{"id":"GO:0060313","count":4},{"id":"GO:0043314","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0051262","count":4}]},{"hash":"1975703484104763768","title":"Cell-Cell Adhesion and Immune Regulation","description":"These proteins cluster around cell\u2013cell adhesion (heterophilic/homophilic) and immune signaling, including negative regulation of cytotoxic T cell degranulation, NK cell activity, and macrophage activation, plus complement activation. The presence of symbiont entry into host cells and regulation of synapse assembly suggests links to host\u2013pathogen interactions and cell communication. Overall, the theme centers on adhesion-mediated immune regulation and intercellular communication.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0046718","count":4},{"id":"GO:0086072","count":4},{"id":"GO:0043318","count":4},{"id":"GO:0051963","count":4}]},{"hash":"1144450390788115437","title":"Adhesion-Driven Intercellular Signaling Across Tissues","description":"Top GO terms indicate strong enrichment for cell-cell adhesion (homophilic/heterophilic) with corroborating signaling roles in nervous system development, synapse assembly, immune signaling, cardiac conduction, and spermatid development, suggesting a common theme of adhesion-mediated intercellular communication across diverse tissues.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":10},{"id":"GO:0007399","count":9},{"id":"GO:0086091","count":9},{"id":"GO:0007157","count":9},{"id":"GO:0051965","count":8}]},{"hash":"1236365032912915780","title":"RNA and protein methylation","description":"The top GO terms are dominated by methylation-related processes: 7-methylguanosine mRNA capping and RNA (guanine-N7)-methylation, plus tRNA methylation and peptidyl-arginine methylation. This pattern points to a cluster rich in methyltransferases and methylation activities affecting both RNA processing and protein modification. Some other terms (epinephrine biosynthesis, organ regeneration, xenobiotic response) may reflect multifunctional proteins or annotation noise, but the core theme is methylation.","confidence":"High","size":18,"edges":151,"triangles":784,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":13},{"id":"GO:0036265","count":12},{"id":"GO:0010243","count":10},{"id":"GO:0042418","count":10},{"id":"GO:0031100","count":10}]},{"hash":"634735533664225134","title":"Inflammation and phagocytosis regulation","description":"Based on the top GO terms, the cluster is enriched for immune and inflammatory processes: acute-phase response, positive regulation of phagocytosis, regulation of IL-8 production, ROS generation, and both positive and negative regulation of inflammatory responses and wound healing. This suggests a cohesive theme around immune activation/modulation and tissue remodeling, with axonogenesis likely reflecting secondary neuroimmune interactions rather than a primary neuronal function. Overall, a label emphasizing inflammation and phagocytosis regulation captures the core shared functions.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060385","count":5},{"id":"GO:0050766","count":5},{"id":"GO:0006953","count":5},{"id":"GO:0044869","count":4},{"id":"GO:2000482","count":4}]},{"hash":"1515167634415486504","title":"Cell Signaling and Growth Regulation","description":"The Top Terms show broad signaling-related functions (signal transduction) and regulation of growth and cell fate (positive regulation of cell growth, G1/S transition in the cell cycle, extrinsic apoptotic signaling). Although some terms reflect organism-specific contexts (neural, plant signaling), the unifying theme is signaling networks that govern cell growth, survival, and fate decisions. This makes a label centered on signaling and growth regulation appropriate.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007165","count":3},{"id":"GO:0007621","count":3},{"id":"GO:0030307","count":3},{"id":"GO:0001975","count":3},{"id":"GO:1900087","count":3}]},{"hash":"1164648542560049763","title":"Dopaminergic Neuronal Signaling","description":"The dominant GO terms cluster around nervous system function, especially dopaminergic synaptic transmission, neuropeptide signaling, and neural processes related to grooming behavior, sensory perception, and enteric nervous system components. A few terms about saliva secretion, kidney development, and thymocyte differentiation appear unrelated to neural signaling, but the core pattern points to dopamine-associated neuronal communication. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":18},{"id":"GO:0072224","count":18},{"id":"GO:0060160","count":18},{"id":"GO:0048484","count":18},{"id":"GO:2000458","count":18}]},{"hash":"2088546896306601329","title":"Dopaminergic neural signaling and development","description":"The cluster is dominated by GO terms related to nervous system activity, including dopaminergic synaptic transmission, neuropeptide signaling, and regulation of dopamine receptor signaling, as well as behaviors linked to neural function (grooming, pain perception) and nervous system development (enteric NS, astrocyte chemotaxis). Some terms like saliva secretion and metanephric glomerulus development appear, but the common thread is neural signaling and development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":18},{"id":"GO:0072224","count":18},{"id":"GO:0060160","count":18},{"id":"GO:0048484","count":18},{"id":"GO:2000458","count":18}]},{"hash":"1430445784331245250","title":"Dopaminergic Signaling and Neuronal Development","description":"Dominant GO terms point to neural communication and development, with strong representation for dopaminergic synaptic transmission, neuropeptide signaling, pain perception, enteric nervous system development, and regulation of dopamine receptor signaling, along with grooming behavior and astrocyte chemotaxis. Some terms like saliva secretion and metanephric glomerulus development are less directly tied but may reflect broader neural-tissue regulation; overall the cluster centers on neuronal signaling and development.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":16},{"id":"GO:0072224","count":16},{"id":"GO:0060160","count":16},{"id":"GO:0048484","count":16},{"id":"GO:2000458","count":16}]},{"hash":"716267147723308241","title":"Mitotic control and cell proliferation","description":"This cluster\u2019s top GO terms predominantly point to cell growth and division processes, including regulation of cell proliferation, cell division, and spindle-assembly checkpoint-related control, along with ribosome biogenesis that supports growth. While there are some developmental terms (dendrite and seminiferous tubule development) and cytoskeletal regulation terms present, the core signal ties to mitotic control and proliferation, with supportive chromatin and stress-related biology. ","confidence":"Medium","size":17,"edges":65,"triangles":77,"max_degree":14,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0050773","count":8},{"id":"GO:0008284","count":8},{"id":"GO:0016575","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0001403","count":7}]},{"hash":"139849621276266222","title":"Pheromone-related lipid biosynthesis and trafficking","description":"These proteins are enriched for fatty acid and sphingolipid biosynthesis (very long-, long-, mono-, polyunsaturated fatty acid elongation) and related lipids, pointing to pheromone precursor metabolism. The presence of pheromone metabolic process and courtship behavior terms suggests a link to pheromone signaling, while post-Golgi vesicle transport and endosome-to-vacuole sorting indicate vesicle trafficking. Together, this points to a module combining pheromone-related lipid biosynthesis with trafficking processes.","confidence":"Medium","size":17,"edges":121,"triangles":560,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0042761","count":5},{"id":"GO:0042810","count":3},{"id":"GO:0034625","count":3},{"id":"GO:0006892","count":3},{"id":"GO:0030148","count":3}]},{"hash":"1288481700363522061","title":"Vesicle trafficking and immune signaling","description":"This cluster centers on intracellular transport and membrane organization (ER-Golgi transport, endosome-to-vacuole sorting, raft polarization, tight junction assembly) with accompanying immune-related processes (cytokine production, B cell differentiation, hemocyte proliferation). The common thread appears to be vesicle trafficking and membrane dynamics that influence immune signaling and cell communication. Some terms like myelination may reflect shared trafficking roles rather than direct immune function, but the overall theme remains vesicle transport in immune contexts.","confidence":"Medium","size":17,"edges":94,"triangles":244,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":2},{"id":"GO:0050715","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0032511","count":2},{"id":"GO:0042552","count":2}]},{"hash":"548585403655042171","title":"Retinoic acid signaling in eye and heart development","description":"The cluster is dominated by retinoid metabolism and retinoic acid response terms, with strong representation of eye development (retinal metabolism, retinol metabolism, optic cup morphogenesis) and cardiovascular development (heart morphogenesis, cardiac muscle development, blood vessel development). This points to a coherent RA-driven program coordinating ocular and cardiac morphogenesis, with some additional metabolic and signaling terms that are supportive but less central. ","confidence":"High","size":17,"edges":130,"triangles":605,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":17},{"id":"GO:0042572","count":17},{"id":"GO:0019413","count":16},{"id":"GO:0007494","count":16},{"id":"GO:0003007","count":16}]},{"hash":"1432212519940144551","title":"Embryonic Morphogenesis and Cell Adhesion","description":"The top GO terms point to developmental organization and tissue formation (neural axon fasciculation, heart tube left/right patterning, dorsal/ventral nervous system development, epiboly) plus various cell adhesion processes (integrin-mediated adhesion, hemidesmosome assembly, receptor clustering, cell spreading, palatal morphogenesis), indicating a cohesive role in embryonic morphogenesis and cell\u2013cell/matrix adhesion.","confidence":"High","size":17,"edges":113,"triangles":473,"max_degree":15,"top_function":"wound healing","top_go_terms":[{"id":"GO:0097155","count":14},{"id":"GO:0055113","count":13},{"id":"GO:0060971","count":13},{"id":"GO:0034446","count":11},{"id":"GO:0043113","count":11}]},{"hash":"885901374701888149","title":"Neurotransmitter Transport and Glycinergic Signaling","description":"This cluster centers on neural communication, with many terms describing neurotransmitter transport and synaptic regulation\u2014dopamine uptake, glycine import, taurine transport, and glycinergic control of synaptic transmission, plus serotonin secretion. Brain-development terms (thalamus and adenohypophysis development) hint at anatomical context, but the shared theme is neurotransmitter handling and glycinergic signaling.","confidence":"Medium","size":17,"edges":6,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905847","count":11},{"id":"GO:0051583","count":11},{"id":"GO:0021794","count":11},{"id":"GO:0015824","count":11},{"id":"GO:0036233","count":11}]},{"hash":"1508102089306571644","title":"Mitochondrial Protein Import and Ribosome Assembly","description":"The top GO terms cluster around mitochondrial function: ribosome assembly, protein import into the mitochondrial matrix, and insertion into the outer membrane, with supporting signals from mitochondrial metabolism (ethanol) and mitophagy regulation. This suggests a cohesive theme of mitochondrial protein handling and maintenance.","confidence":"High","size":17,"edges":66,"triangles":101,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006067","count":4},{"id":"GO:0061668","count":4},{"id":"GO:0045040","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0048147","count":2}]},{"hash":"1549002840072970765","title":"Embryonic development and tissue morphogenesis","description":"This cluster shows enrichment for nervous system development, somite formation, cardiac left ventricle formation, and branching morphogenesis, suggesting proteins involved in broad embryonic development and multi-tissue morphogenesis rather than a single tissue. Regulatory-related GO terms (transcription factor activity regulation, RNA processing, centrosome localization) further support a role in developmental control mechanisms. ","confidence":"Medium","size":17,"edges":83,"triangles":270,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0048666","count":5},{"id":"GO:0060766","count":4},{"id":"GO:0003218","count":4},{"id":"GO:0001756","count":4},{"id":"GO:0007399","count":4}]},{"hash":"2005785955645348462","title":"ER Stress and NF-kB/NFAT Signaling","description":"The top GO terms cluster around cellular stress responses: unfolded protein response (ER stress), NF-kappaB activation, and calcineurin-NFAT signaling, plus protein ubiquitination and phosphatase regulation. This suggests a cohesive theme of proteostasis-driven signaling and transcriptional regulation under stress, with ancillary ties to metabolic and xenobiotic responses. The presence of insulin secretion and neuron-related terms like substantia nigra development may reflect tissue-specific contexts of these stress-signaling pathways. Overall, a signaling-centered cluster driven by ER stress and NF-kB/NFAT cross-talk.","confidence":"Medium","size":17,"edges":68,"triangles":115,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006986","count":9},{"id":"GO:0043123","count":8},{"id":"GO:0070979","count":8},{"id":"GO:0035774","count":7},{"id":"GO:0006351","count":7}]},{"hash":"1670845718948497255","title":"Tissue morphogenesis and ECM interactions","description":"The terms point to developmental processes across multiple tissues (lymphangiogenesis, tendon, skin, eye, podocyte development) and regulation of differentiation, complemented by integrin biosynthesis and protein heterotrimerization, indicating roles in extracellular matrix interactions and assembly during tissue formation. This suggests a coherent theme of morphogenesis coordinated with ECM remodeling across diverse tissues.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1901492","count":10},{"id":"GO:2000590","count":10},{"id":"GO:0045112","count":10},{"id":"GO:0070208","count":10},{"id":"GO:0035989","count":10}]},{"hash":"1469148657909747895","title":"Eye Development and Sensory Signaling","description":"The top GO terms cluster around visual perception and retina development (GO:0007601, GO:0060041), with supporting sensory perception of pain and temperature response (GO:0019233, GO:0071502). This points to a shared theme of sensory signaling in the eye/retina, likely involving GPCR- and MAPK-mediated pathways (GO:0016998, GO:0070374, GO:0002031). Some terms such as diet-induced thermogenesis and cell wall catabolic process are less connected and may reflect noise or multi-function proteins. Overall, the core motif is eye-related sensory signaling and associated intracellular signaling.","confidence":"Medium","size":17,"edges":44,"triangles":48,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0002024","count":13},{"id":"GO:0007601","count":10},{"id":"GO:0060041","count":9}]},{"hash":"71343156547763474","title":"RNA processing and ribosome biogenesis","description":"Based on top GO terms, this cluster centers on RNA metabolism and ribosome assembly: mRNA splicing via spliceosome, maturation of SSU-rRNA, ribosome biogenesis, and steps related to translation initiation. Additional terms reference chromatin modification and cilium assembly, which may reflect broader nuclear/cytoplasmic coordination, but the dominant signal is RNA processing and ribosome production.","confidence":"Medium","size":17,"edges":92,"triangles":267,"max_degree":15,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0016575","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0006349","count":4},{"id":"GO:0051567","count":4}]},{"hash":"2003813139622524005","title":"Meiotic chromosome dynamics and synaptonemal complex","description":"The cluster is dominated by meiotic-related GO terms: chromosome condensation and separation, synaptonemal complex assembly, centromeric cohesion, and regulation of meiotic DSB formation, plus related nuclear import processes (NLS-bearing proteins, ribosomal protein import). This combination points to proteins involved in chromosome pairing and segregation during meiosis, rather than general housekeeping. Confidence reflects a strong, cohesive meiotic theme across the terms.","confidence":"High","size":17,"edges":132,"triangles":624,"max_degree":16,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006610","count":8},{"id":"GO:0070058","count":8},{"id":"GO:0010032","count":8},{"id":"GO:0051307","count":8},{"id":"GO:0006607","count":8}]},{"hash":"1629379875703123900","title":"Telomere-Subtelomere Heterochromatin and DNA Replication","description":"This cluster is enriched for GO terms tying telomere- and subtelomere-associated heterochromatin formation to replication and repair processes, including DNA replication, mitotic DNA replication initiation, replication fork protection, and break-induced replication, plus cell cycle and meiotic recombination nodules; the combination suggests a functional unit focused on maintaining chromatin state at chromosome ends while coordinating replication and genome maintenance.","confidence":"High","size":17,"edges":133,"triangles":635,"max_degree":16,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0030466","count":10},{"id":"GO:0006348","count":10},{"id":"GO:0031939","count":10},{"id":"GO:1902975","count":9},{"id":"GO:0030163","count":9}]},{"hash":"1806353833860557334","title":"Rho GTPase\u2013Driven Actin Remodeling","description":"The cluster is strongly enriched for actin cytoskeleton organization, lamellipodium assembly, and small GTPase/Rho-mediated signaling, pointing to coordinated actin remodeling regulated by Rho GTPases as the central theme. Peripheral terms like IGF receptor signaling may be supportive but do not define the core function.","confidence":"High","size":17,"edges":118,"triangles":464,"max_degree":16,"top_function":"establishment or maintenance of cell polarity","top_go_terms":[{"id":"GO:0030032","count":9},{"id":"GO:0007015","count":8},{"id":"GO:0035023","count":7},{"id":"GO:0060313","count":7},{"id":"GO:0043314","count":7}]},{"hash":"1924016511176408199","title":"Embryonic morphogenesis and RA signaling","description":"The top GO terms point to diverse embryonic morphogenesis across multiple tissues (heart, hindlimb, eye, gonads) and a shared retinoic acid\u2013responsive transcriptional program, suggesting a theme of developmental patterning and organ formation governed by RA signaling.","confidence":"High","size":17,"edges":8,"triangles":4,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0071300","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0035116","count":3},{"id":"GO:0008584","count":3}]},{"hash":"1534489464672564044","title":"Renal development and vascular-immune signaling","description":"The cluster centers on kidney development signals (glomerular basement membrane development, metanephric mesenchyme migration regulation, cell adhesion, ECM-related processes) and also includes vascular and immune remodeling cues (complement activation, blood coagulation, lymphangiogenesis, monocyte chemokine production). While some neuronal-related terms appear, the dominant theme ties renal development to immune-vascular interactions, justifying the label. ","confidence":"Medium","size":17,"edges":32,"triangles":34,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0071639","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0007155","count":6},{"id":"GO:0032836","count":6}]},{"hash":"29791236355976336","title":"Ubiquitin-mediated NF-\u03baB and JNK signaling","description":"The cluster centers on ubiquitin-dependent protein turnover and signaling regulation, including autoubiquitination, JNK cascade regulation, TNF signaling, and canonical NF-\u03baB activation, suggesting a core role in ubiquitin-driven inflammatory and apoptotic signaling. Some histone-related terms may reflect broader chromatin- or epigenetic-associated regulation.","confidence":"High","size":17,"edges":29,"triangles":8,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":6},{"id":"GO:0046328","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0043123","count":5},{"id":"GO:0033209","count":5}]},{"hash":"141545775454585820","title":"RNA processing and translation regulation","description":"The top GO terms cluster around post-transcriptional control: alternative splicing via the spliceosome, mRNA splicing, mRNA export, polyadenylation, ncRNA- and miRNA-mediated silencing, and formation of the translation preinitiation complex. This points to proteins coordinating RNA processing and the initiation of translation, rather than transcriptional regulation, so the label captures the shared function of the cluster.","confidence":"High","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0000117","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0048026","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0031047","count":2}]},{"hash":"18374892673326271","title":"Unknown","description":"The GO terms span ubiquitination, mRNA processing, adipocyte differentiation, heat and mechanical stress responses, vitamin D signaling, pinocytosis, cell communication, and myeloid apoptosis, indicating a broad mix of metabolism, gene expression, signaling, and immune-related processes with no single, coherent function tying all proteins together. Therefore no clear theme emerges, so a general Unknown label is appropriate.","confidence":"","size":17,"edges":15,"triangles":7,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033280","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0006397","count":6},{"id":"GO:0045444","count":5},{"id":"GO:0009408","count":5}]},{"hash":"1980547992850940191","title":"Cardiovascular development and immune signaling","description":"These proteins cluster around signaling that governs heart development and vascular responses (VEGF, prostaglandin signaling, hyaluronan metabolism) while also including immune-related processes (IL-7 response, B cell maturation). The shared theme appears to be regulated signaling pathways coordinating development, vascular remodeling, and immunity, with supporting phosphorylation and JNK pathway modulation. ","confidence":"Medium","size":17,"edges":24,"triangles":14,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046329","count":17},{"id":"GO:0018107","count":17},{"id":"GO:0098761","count":17},{"id":"GO:0016477","count":17},{"id":"GO:2001275","count":17}]},{"hash":"1435855906394067582","title":"Neuronal Ion Transport and Synaptic Transmission","description":"The top GO terms are dominated by neuronal signaling and ion transport\u2014calcium and sodium transmembrane transport, neuromuscular junction development, transmission of nerve impulse, and postsynaptic receptor diffusion/trapping\u2014collectively pointing to synaptic function and ion-channel\u2013mediated communication. Some terms are broader (cell death, fungicide response, vasculogenesis, xenobiotic transport), but the core signal aligns with neuronal signaling and synaptic maintenance.","confidence":"High","size":17,"edges":134,"triangles":650,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0070588","count":14},{"id":"GO:0007528","count":13},{"id":"GO:0035725","count":13},{"id":"GO:0061772","count":13},{"id":"GO:0016338","count":13}]},{"hash":"1599366892753690109","title":"Immune signaling and growth regulation","description":"Main terms cover NK cell cytotoxicity, immune regulation, EGFR/ERK signaling, STAT phosphorylation, and growth regulation; several \"negative regulation\" terms tie these together as regulators of signaling and cell interactions, implying a cluster centered on immune and growth signal modulation.","confidence":"Medium","size":17,"edges":105,"triangles":387,"max_degree":16,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0042267","count":16},{"id":"GO:0051463","count":15},{"id":"GO:0042518","count":15},{"id":"GO:0033629","count":15},{"id":"GO:0021697","count":15}]},{"hash":"1773913099123173013","title":"Actin Cytoskeleton Dynamics in Muscle and Nerve","description":"The cluster is dominated by terms about actin-based structures and remodeling (lamellipodium/microspike assembly, actin cytoskeleton organization) plus muscle-related processes (muscle attachment, calcium-regulated contraction) and neural context (olfactory nerve organization). This suggests a coherent module of actin cytoskeleton dynamics shaping muscle and nerve structure and function.","confidence":"High","size":17,"edges":4,"triangles":0,"max_degree":3,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030032","count":6},{"id":"GO:0021629","count":6},{"id":"GO:0016203","count":6},{"id":"GO:0070493","count":6},{"id":"GO:0035023","count":6}]},{"hash":"762809178845619952","title":"Plant development and cell cycle regulation","description":"The cluster includes GO terms tied to plant reproductive development (inflorescence development, pollen maturation) and core cellular processes (cell division, mitotic cell cycle, translation, ubiquitination, miRNA transcription), suggesting a group of proteins coordinating growth, development, and gene expression in plants.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0032930","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0010229","count":1}]},{"hash":"433636135458787992","title":"RNA Processing and Transcription Regulation","description":"This cluster shows a clear RNA-centric theme: regulation of transcription by RNA polymerase II, mRNA splicing via the spliceosome, nonsense-mediated decay, and regulatory ncRNA-mediated gene silencing, along with a specific rRNA processing step. These collectively point to RNA metabolism and control of gene expression at the RNA level. Some terms like DNA replication and embryonic morphogenesis appear less central but may reflect broader cellular context or pleiotropy. ","confidence":"Medium","size":17,"edges":89,"triangles":330,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0001666","count":3},{"id":"GO:0000184","count":3},{"id":"GO:0000464","count":3}]},{"hash":"159394340115126151","title":"TNF-NF-\u03baB/JNK immune signaling","description":"This cluster is driven by GO terms related to TNF-mediated signaling, activation of NF-kappaB-inducing kinase, and regulation of the JNK cascade, pointing to a core theme of TNF-driven inflammatory and stress signaling in immune contexts. Additional terms touch on immune processes such as V(D)J recombination and antiviral transport regulation, as well as epigenetic regulation, suggesting broader immune- and chromatin-related roles. Overall, the strongest common thread is TNF/NF-\u03baB/JNK signaling in immune responses.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090073","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0033151","count":2}]},{"hash":"1143676560344741207","title":"Angiogenesis and Megakaryocyte Development Signaling","description":"These proteins co-occur with strong signals for blood vessel formation and hematopoietic lineage development: angiogenesis, KIT signaling, PDGF receptor signaling, and megakaryocyte development are prominent, with accompanying immune signaling (IL-2 production, TCR modulation) that ties into hematopoietic-immune interactions. While there is a broad tissue homeostasis term, the dominant theme is vascular/hematopoietic signaling. ","confidence":"High","size":17,"edges":53,"triangles":98,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":14},{"id":"GO:2001275","count":13},{"id":"GO:0010641","count":13},{"id":"GO:0007417","count":13},{"id":"GO:1900042","count":13}]},{"hash":"973215231206935735","title":"Cardiac morphogenesis and calcium signaling","description":"Top GO terms show a strong emphasis on heart-related biology: outflow tract morphogenesis, Purkinje to ventricular signaling, and positive regulation of ATPase-coupled calcium transport, all pointing to cardiac development and calcium handling. Cell-matrix adhesion also supports cardiac tissue structure. A few terms (sperm binding to zona pellucida, otolith tethering, sensory perception of sound) are not cardiac-specific and likely reflect broader membership or annotation noise, but the dominant theme remains heart development and calcium signaling.","confidence":"Medium","size":17,"edges":16,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007339","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0035889","count":2}]},{"hash":"1125590474234528929","title":"Immune Activation and Complement/T-cell Regulation","description":"The cluster\u2019s top GO terms are dominated by immune-related processes: classical complement activation, cytokine production, T cell costimulation, and negative regulation of T cell activation, pointing to proteins involved in immune signaling and modulation. While a few terms touch on unrelated areas (gastrointestinal epithelium maintenance, spermatid development, atrial cardiac depolarization), the prominent signal is immune activation and regulation, making this a coherent label. ","confidence":"Medium","size":17,"edges":64,"triangles":84,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":8},{"id":"GO:0030277","count":6},{"id":"GO:0006508","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0045404","count":5}]},{"hash":"21915720802340316","title":"ER Protein Folding and ERAD Quality Control","description":"The cluster is dominated by terms related to folding and quality control of proteins in the endoplasmic reticulum: protein folding in ER, ER-associated degradation (ERAD), misfolded protein transport, and ubiquitin-proteasome\u2013mediated quality control. Additional signals for heat response and post-translational targeting to membranes support a cohesive theme of ER-based protein homeostasis under stress.","confidence":"High","size":17,"edges":99,"triangles":345,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009408","count":16},{"id":"GO:0006452","count":15},{"id":"GO:0031204","count":15},{"id":"GO:0035719","count":15},{"id":"GO:0034975","count":15}]},{"hash":"1110077209477621742","title":"Neuronal adhesion and synapse organization","description":"The cluster is dominated by GO terms for neuron cell\u2013cell adhesion, cadherin-mediated adhesion, and synapse-related processes (synapse assembly, synapse organization, positive regulation of synaptic vesicle clustering, and localization to the synapse), along with nervous system development and locomotory behavior, pointing to proteins involved in establishing and maintaining neural connections. An outlier term related to bone maturation likely reflects multifunctional proteins rather than core function. ","confidence":"High","size":17,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007158","count":8},{"id":"GO:0007156","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0051965","count":6},{"id":"GO:2000809","count":5}]},{"hash":"74354804664187414","title":"Lipid and nucleotide metabolism","description":"The terms cluster around lipid biosynthesis (prostaglandin, bile acid, acyl-CoA) and nucleotide metabolism (adenosine, guanosine, ribonucleoside catabolic processes), with glutathione biosynthesis and proteolysis reflecting broader metabolism; together they point to lipid- and nucleotide-centered metabolic activity.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":3},{"id":"GO:0006508","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0006699","count":2},{"id":"GO:0006750","count":2}]},{"hash":"1726701045533662569","title":"Bacterial fatty acid and acetyl-CoA metabolism","description":"This cluster is dominated by terms related to lipid and fatty acid metabolism (long-chain and very long-chain fatty acids, lipoteichoic acid biosynthesis) and acetyl-CoA\u2013related pathways (acetyl-CoA biosynthesis, pyruvate fermentation to acetate, propionate catabolism). The presence of menaquinone biosynthesis further supports bacterial energy and electron transport metabolism. One term (seed coat development) is plant-specific and likely an annotation quirk, but the overall pattern clearly centers on bacterial lipid metabolism and related energy/biosynthetic pathways.","confidence":"High","size":17,"edges":107,"triangles":400,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010214","count":13},{"id":"GO:0070395","count":13},{"id":"GO:0019427","count":13},{"id":"GO:0008206","count":13},{"id":"GO:0044539","count":13}]},{"hash":"2247126590383279077","title":"mRNA Splicing and Translation Regulation","description":"The proteins cluster around post-transcriptional control, including spliceosome-mediated regulation of alternative splicing, mRNA splicing activation, and mRNA export, plus components involved in translation initiation (preinitiation complex formation and eIF4F assembly) and miRNA-mediated silencing. This combination points to a cohesive role in coordinating mRNA maturation/export with the initiation of translation.","confidence":"High","size":17,"edges":15,"triangles":7,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":3},{"id":"GO:0048026","count":3},{"id":"GO:1900363","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0001731","count":3}]},{"hash":"461510063724831577","title":"Embryonic skeletogenesis and organ morphogenesis","description":"The terms center on embryonic development and morphogenesis, including bone/craniofacial skeletogenesis, lens differentiation, endoderm/foregut morphogenesis, somite axis patterning, and BMP/EMT regulation, suggesting a cluster of proteins involved in early developmental patterning and organ formation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0016311","count":2},{"id":"GO:0010718","count":2},{"id":"GO:0021740","count":2}]},{"hash":"1029592410938158867","title":"Neural development and synapse formation","description":"The cluster shows strong representation for nervous system development, synapse assembly/organization, and cell adhesion, suggesting a cohesive function in neural connectivity and synaptic formation; ancillary terms like ossification and angiogenesis may reflect broader morphogenesis or pleiotropy rather than the core neural role.","confidence":"Medium","size":17,"edges":22,"triangles":6,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":11},{"id":"GO:0007156","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0051965","count":10},{"id":"GO:0043931","count":9}]},{"hash":"468647822987446304","title":"Deubiquitinases and ubiquitination regulators","description":"Top GO terms cluster around negative regulation of protein ubiquitination and multiple linkage-specific deubiquitination activities (K11, K63, K48, K6), with additional hints from DNA repair and signaling regulation. This pattern strongly suggests proteins that edit or regulate ubiquitin chains rather than act as end carriers, justifying a label centered on deubiquitination and ubiquitin pathway control.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":2},{"id":"GO:0035871","count":2},{"id":"GO:0070536","count":2},{"id":"GO:0071108","count":2},{"id":"GO:0006281","count":2}]},{"hash":"821264863946765982","title":"Neuronal GPCR-ERK Signaling","description":"The terms cluster around neuronal signaling: neuropeptide signaling, GPCR pathways, ERK cascades (ERK1/2 and ERK5), calcium signaling, and neuron projection development. The presence of sensory (sound) and feeding-related responses further supports a neural signaling module driven by GPCR-ERK pathways, with calcium involvement and neural development themes.","confidence":"High","size":17,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0007218","count":4},{"id":"GO:0032094","count":3},{"id":"GO:0007189","count":3},{"id":"GO:0070378","count":2}]},{"hash":"550164139821609343","title":"Glycoprotein glycosylation and epithelial polarity","description":"This cluster is enriched for glycosylation-related processes (arabinogalactan protein metabolism, Hyp-O-glycosylation, poly-N-acetyllactosamine biosynthesis) and cell-surface/epithelial organization terms (follicle cell adhesion, maintenance of polarity). The mix of plant and animal development terms suggests a common theme around glycoprotein construction and cell-surface interactions that drive tissue organization and development.","confidence":"Medium","size":17,"edges":83,"triangles":210,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":6},{"id":"GO:0010405","count":5},{"id":"GO:0010493","count":5},{"id":"GO:0018258","count":5},{"id":"GO:0007299","count":5}]},{"hash":"2031548689848766058","title":"Proteoglycan biosynthesis and sulfation metabolism","description":"Based on dominant GO terms for proteoglycan biosynthesis (heparan sulfate and chondroitin sulfate) and protein sulfation, the core function of this cluster appears to be synthesis and post-translational modification of proteoglycans and glycosaminoglycans. Other metabolic terms (xenobiotic and bile acid metabolism) seem ancillary to this main theme.","confidence":"High","size":17,"edges":100,"triangles":325,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0045600","count":12},{"id":"GO:0030210","count":12},{"id":"GO:0006805","count":12},{"id":"GO:0006477","count":12},{"id":"GO:0030573","count":12}]},{"hash":"2247687349663214090","title":"Dopaminergic and Neuropeptide Signaling","description":"This cluster is dominated by GO terms related to nervous system function, including dopaminergic synaptic transmission, neuropeptide signaling, enteric nervous system development, grooming behavior, and pain perception, pointing to a common theme of neural signaling and behavior. Saliva secretion under autonomic control and regulation of astrocyte chemotaxis further support nervous system involvement. Some outliers (metanephric glomerulus development, DN2 thymocyte differentiation) are less consistent but do not override the main neural theme. Confidence: High","confidence":"","size":17,"edges":50,"triangles":26,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":17},{"id":"GO:0072224","count":17},{"id":"GO:0060160","count":17},{"id":"GO:0048484","count":17},{"id":"GO:2000458","count":17}]},{"hash":"682877237134371177","title":"Host\u2013pathogen interaction and antimicrobial processes","description":"The cluster shows strong signals for pathogen-related processes: defense response to bacterium, cytolysis, and both peptidoglycan and cell wall macromolecule catabolic processes, plus viral release from host cell. These terms point to themes around host\u2013pathogen interactions and antimicrobial remodeling. Additional terms like electron transport chain and signaling modulation may reflect broader cellular states, but the core appears pathogen-associated. ","confidence":"Medium","size":17,"edges":12,"triangles":1,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":16},{"id":"GO:0019835","count":16},{"id":"GO:0019076","count":16},{"id":"GO:0009253","count":16},{"id":"GO:0007194","count":16}]},{"hash":"942507409714641557","title":"Neural signaling and development","description":"The cluster\u2019s top GO terms converge on nervous system development and communication: enteric nervous system development, dopaminergic synaptic transmission, neuropeptide signaling, regulation of dopamine receptor signaling, sensory perception of pain, grooming behavior, and astrocyte chemotaxis. A few terms like saliva secretion, metanephric glomerulus development, and DN2 thymocyte differentiation are more peripheral but can reflect broader autonomic or developmental contexts; overall, the dominant theme is neural signaling and development.","confidence":"High","size":17,"edges":7,"triangles":3,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":17},{"id":"GO:0072224","count":17},{"id":"GO:0060160","count":17},{"id":"GO:0048484","count":17},{"id":"GO:2000458","count":17}]},{"hash":"955119950953908096","title":"Neural crest migration and axon guidance","description":"The top terms strongly point to neural development, especially neural crest cell migration and axon guidance (semaphorin-plexin signaling, sympathetic and branchiomotor neuron guidance, neuron adhesion, sensory perception of sound). A few bone development terms appear but are likely less central to the cluster\u2019s primary function. Overall, the cluster appears to represent neural crest\u2013driven nervous system formation and axon pathfinding.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0007158","count":5},{"id":"GO:0007605","count":4},{"id":"GO:0003273","count":4}]},{"hash":"1156201302002028081","title":"Embryonic development and tissue morphogenesis","description":"The GO terms cluster around broad developmental processes across multiple tissues, including epithelial-to-mesenchymal transition in heart development, pattern formation, cartilage and skeletal muscle morphogenesis, placental/placental-related differentiation, and lamellipodium/cytoskeletal dynamics, indicating a common theme of development and organogenesis rather than a single pathway. Confidence: Medium.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0060972","count":2},{"id":"GO:0035270","count":2}]},{"hash":"2067556595071473191","title":"Neural crest migration and axon guidance","description":"Many terms cluster around axon pathfinding (semaphorin-plexin signaling, axonal fasciculation, neuron projection guidance) and neural crest\u2013derived migration (ventral trunk neural crest migration, trigeminal nerve organization, branchiomotor neuron axon guidance, sympathetic neuron projection). Together they point to developmental programs coordinating neural crest movements with targeted neurite outgrowth, making this label appropriate and representative.","confidence":"High","size":17,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":6},{"id":"GO:0036486","count":5},{"id":"GO:1902287","count":5},{"id":"GO:0021637","count":5},{"id":"GO:0097490","count":5}]},{"hash":"2000130588389765623","title":"Cilia and flagella assembly and sperm motility","description":"The cluster is enriched for terms related to cilium/axoneme assembly, regulation of cilium movement, and flagellated sperm motility, including tubulin post-translational modifications like polyglutamylation and polyglycylation, which are key for microtubule-based motility in cilia/flagella. These connections strongly suggest a function in building and driving ciliary/flagellar movement, especially in sperm.","confidence":"High","size":17,"edges":25,"triangles":15,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0018094","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0030516","count":2},{"id":"GO:0007288","count":2},{"id":"GO:0003351","count":2}]},{"hash":"1174612327079245875","title":"Diverse Metabolic Enzymes and Metal Transport","description":"Top GO terms indicate a broad mix of metabolic activities, including phospholipid dephosphorylation and dephosphorylation in general, stilbene catabolic process, antibiotic biosynthetic process, epoxygenase P450 pathway, L-serine biosynthesis, and oxidation\u2013reduction, along with copper and zinc ion transport. This pattern points to a cluster of proteins involved in multiple metabolic routes and metal ion transport rather than a single cohesive function, so the label reflects diversity in metabolism and transport.","confidence":"Medium","size":17,"edges":11,"triangles":2,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0046839","count":6},{"id":"GO:0046272","count":6},{"id":"GO:0097755","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0017000","count":4}]},{"hash":"1244515725066907804","title":"Diverse Substrate Transmembrane Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of a wide range of substrates (ions like Na+, phosphate, nitrate; sugars such as arabinose, fucose, galactose; sialic acid; xenobiotics) and includes a neuronal vesicular transporter function (neurotransmitter loading into synaptic vesicle). The common thread is membrane transporter activity with broad substrate specificity.","confidence":"High","size":17,"edges":20,"triangles":12,"max_degree":5,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0035725","count":15},{"id":"GO:0006855","count":15},{"id":"GO:0006004","count":15},{"id":"GO:0015751","count":15},{"id":"GO:0015739","count":15}]},{"hash":"182370376919484907","title":"Developmental Signaling and Cytoskeletal Regulation","description":"The terms center on actin filament network formation, regulation of GTPase activity, Wnt signalosome assembly, and various development-related processes (heart, compound eye, meristem). This points to proteins involved in coordinating signaling pathways with cytoskeletal dynamics during development, despite some heterogeneous, cross-species terms.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051639","count":2},{"id":"GO:0043087","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0045736","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1226217133026364719","title":"Neural signaling and sensory perception","description":"Based on the enrichment of GO terms related to neuronal communication and sensory detection (regulation of synaptic transmission, glutamatergic; detection of light stimulus; sensory perception of umami taste; cellular response to electrical stimulus) and supporting terms linked to energy metabolism, the cluster seems to center on neural signaling and sensory pathways. Some bacterial cell-wall\u2013related terms appear among the top terms, but the strongest signal points to neural function, suggesting these proteins cluster around neuronal communication and sensory processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051966","count":5},{"id":"GO:0016998","count":5},{"id":"GO:0019076","count":5},{"id":"GO:0009253","count":5},{"id":"GO:0032781","count":4}]},{"hash":"1144212320535330891","title":"ECM and Junction Assembly","description":"The top GO terms point to extracellular matrix interactions and structural cell features: smooth septate junction assembly, cell-matrix adhesion, and basement membrane development, plus otolith tethering, which together suggest a theme of ECM organization and junction formation. Some immune-related terms appear but do not dominate the cluster\u2019s core function, so the central signal is structural adhesion and ECM dynamics.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090528","count":6},{"id":"GO:0007605","count":6},{"id":"GO:0007160","count":6},{"id":"GO:0032836","count":6},{"id":"GO:0002853","count":6}]},{"hash":"222609914109397081","title":"Embryonic heart morphogenesis","description":"The cluster's prominent GO terms center on heart development and morphogenesis, including outflow tract morphogenesis, endocardial cushion morphogenesis, left/right asymmetry, cardioblast differentiation, and related embryonic cardiac processes, suggesting a cohesive cardiovascular development theme despite a few unrelated terms.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0003151","count":2},{"id":"GO:0021554","count":2},{"id":"GO:0010991","count":2},{"id":"GO:0035922","count":2}]},{"hash":"1911296086812664088","title":"Neural development and stress-induced apoptosis","description":"The GO terms highlight brain development (cerebral cortex development, corpus callosum development, axon regeneration) and apoptosis/stress pathways (ER-stress\u2013induced apoptosis, JNK cascade regulation, anoikis). This suggests a cluster of proteins involved in neural development with regulated cell fate under stress. A few terms (meiotic DNA double-strand break formation, galactose-regulated transcription, cardiac muscle proliferation) are more peripheral or reflect multifunctionality, but do not overturn the central theme. Overall, the cluster seems best described by neural development coupled to stress-responsive apoptosis.","confidence":"Medium","size":17,"edges":12,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":17},{"id":"GO:0070059","count":17},{"id":"GO:0046329","count":17},{"id":"GO:0072428","count":17},{"id":"GO:0021987","count":17}]},{"hash":"2072407085615181645","title":"Organogenesis signaling","description":"These proteins appear linked to organ development and morphogenesis across tissues, with terms spanning kidney development (metanephric glomerulus development, renal tubule morphogenesis), nervous system patterning (axon guidance, synapse assembly), and regulation of processes like angiogenesis and mineralization. The inclusion of broad signaling pathways (GPCR signaling, JAK-STAT regulation, Toll signaling) suggests a shared role in coordinating developmental signaling networks that drive organogenesis. Confidence: High","confidence":"","size":17,"edges":114,"triangles":421,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0072224","count":15},{"id":"GO:0021972","count":15},{"id":"GO:1900155","count":15},{"id":"GO:0051965","count":15},{"id":"GO:0016525","count":15}]},{"hash":"598429156351629189","title":"Diverse solute transporters","description":"This cluster is strongly enriched for transmembrane transport terms across a wide range of substrates (sialic acid, nitrite, phosphate, sodium, galactose, fucose, xenobiotics, 4-hydroxyphenylacetate, nitrate) and includes a vesicular neurotransmitter loading term, pointing to a collection of membrane transporter proteins with broad substrate specificity rather than a single pathway. The diversity of substrates supports a general \"membrane transporters\" theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0015739","count":6},{"id":"GO:0015707","count":5},{"id":"GO:0035435","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0015757","count":5}]},{"hash":"1435483666231462258","title":"ECM Remodeling and Regenerative Signaling","description":"The GO terms cluster around collagen fibril organization and angiogenesis, with indications of ERK signaling, neuron adhesion and axon regeneration, and immune-related differentiation, suggesting a theme of extracellular matrix\u2013mediated tissue remodeling that supports vascular and neural regeneration, with broader involvement in mesenchymal-epithelial signaling and immune cell development.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0014012","count":2},{"id":"GO:1905240","count":2}]},{"hash":"453417312176183114","title":"Urokinase-mediated fibrinolysis and lipoprotein clearance","description":"This cluster is driven by fibrinolysis and urokinase plasminogen activator signaling, with accompanying terms on lipoprotein lipase activity and chylomicron remnant clearance, suggesting a shared role in proteolytic remodeling and lipid processing. While other terms (e.g., synaptic transmission, locomotory behavior) appear, the core theme centers on fibrinolysis and lipid clearance. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":5},{"id":"GO:0071503","count":4},{"id":"GO:0043388","count":4},{"id":"GO:2001243","count":4},{"id":"GO:0045056","count":4}]},{"hash":"492161045747910856","title":"Neural development and axon guidance","description":"The cluster is dominated by GO terms for motor neuron axon guidance, cell-matrix adhesion, and cerebral cortex development, which together point to neural development and neurite navigation. While there are links to telomere maintenance, ER-stress\u2013related apoptosis, JNK signaling, and DNA damage checkpoints, these seem more reflective of broad cellular stress and cell-cycle context rather than a core neural function; the strongest signal is neural development and axon guidance, with adhesion supporting neurite interactions.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008045","count":5},{"id":"GO:0007160","count":5},{"id":"GO:1904355","count":4},{"id":"GO:0007098","count":4},{"id":"GO:0032212","count":4}]},{"hash":"247906310201247761","title":"Embryonic Morphogenesis and Neural Development","description":"These proteins are enriched for GO terms spanning embryonic development across multiple organs (e.g., pancreas, pituitary, limbs, skeletal system, heart outflow tract) and neural differentiation (cerebral cortex regionalization, neuronal commitment). The common thread is early embryonic patterning and tissue morphogenesis with a strong emphasis on neural development, so the label reflects both broad organogenesis and neural lineage specification without pinpointing a single tissue.","confidence":"Medium","size":17,"edges":7,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":11},{"id":"GO:0042733","count":10},{"id":"GO:0021983","count":10},{"id":"GO:0021796","count":10},{"id":"GO:0035116","count":10}]},{"hash":"1275186247915359648","title":"Signaling and cytoskeletal regulation","description":"The GO terms point to modulation of signaling pathways (MAP kinase activity, GPCR signaling, small GTPase\u2013mediated signaling) and to cytoskeletal/architectural processes (centrosome localization, spindle organization, microvillus assembly), with some epithelial differentiation contexts. This suggests a cohesive theme of coordinating signaling with cytoskeletal dynamics, rather than a single specific function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043407","count":1},{"id":"GO:0051661","count":1},{"id":"GO:0051056","count":1},{"id":"GO:0060487","count":1},{"id":"GO:0007051","count":1}]},{"hash":"682878497071187979","title":"Dopaminergic/neuropeptide signaling and neural development","description":"Top GO terms are dominated by neural signaling and development: dopaminergic synaptic transmission, neuropeptide signaling, regulation of dopamine receptor signaling, grooming behavior, and sensory perception of pain. While some terms like saliva secretion and metanephric glomerulus development appear, the strongest cluster centers on neural communication and dopaminergic pathways, supporting a label focused on neural signaling and development.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":17},{"id":"GO:0072224","count":17},{"id":"GO:0060160","count":17},{"id":"GO:0048484","count":17},{"id":"GO:2000458","count":17}]},{"hash":"1503555995053017352","title":"Neural development and axon guidance","description":"The proteins are dominated by GO terms related to nervous system development, neurogenesis, PNS development, myelination, neural cell adhesion, and signaling pathways involved in neural patterning and connectivity (Roundabout/ROBO and Hedgehog via Smoothened), pointing to a cohesive role in neural formation and axon guidance. Some terms like T cell costimulation and symbiont entry appear as outliers but do not define the core theme.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":11},{"id":"GO:0045663","count":11},{"id":"GO:0042552","count":11},{"id":"GO:0007224","count":11},{"id":"GO:0007422","count":11}]},{"hash":"1285003631944662892","title":"Dopaminergic neural signaling and behavior","description":"The cluster is dominated by terms tied to nervous system signaling\u2014dopaminergic synaptic transmission, neuropeptide signaling, dopamine receptor regulation\u2014and behavior-associated processes (grooming, pain perception). While a few terms relate to non-neural tissues (saliva secretion, kidney development), the shared theme is dopamine-centered neural communication and related behaviors, justifying the label.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":17},{"id":"GO:0072224","count":17},{"id":"GO:0060160","count":17},{"id":"GO:0048484","count":17},{"id":"GO:2000458","count":17}]},{"hash":"1114096248828681048","title":"Dopaminergic Neurotransmission and Neural Development","description":"Most terms point to neural signaling and development: dopaminergic synaptic transmission, neuropeptide signaling, regulation of dopamine receptor signaling, grooming behavior, and pain perception. A couple of terms (saliva secretion, metanephric glomerulus development) seem peripheral, but the dominant theme is nervous system function and dopamine-related communication.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":16},{"id":"GO:0072224","count":16},{"id":"GO:0060160","count":16},{"id":"GO:0048484","count":16},{"id":"GO:2000458","count":16}]},{"hash":"1627703772239955110","title":"Pancreatic beta-cell insulin secretion and glucose response","description":"Most top GO terms point to pancreatic beta-cell biology\u2014regulation of insulin secretion in response to glucose, beta-cell development/proliferation, and glucose sensing\u2014supported by intracellular signal transduction. Some terms (dsRNA transport, sperm motility, digit morphogenesis) are less related, but the dominant theme centers on beta-cell function and insulin-glucose signaling, suggesting this cluster represents pancreatic beta-cell physiology.","confidence":"Medium","size":16,"edges":52,"triangles":74,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0061178","count":3},{"id":"GO:0035556","count":2},{"id":"GO:0044342","count":2},{"id":"GO:0009749","count":2},{"id":"GO:0033227","count":2}]},{"hash":"1795833607379270271","title":"Ubiquitin-Driven NF-\u03baB Immune Signaling","description":"This cluster centers on ubiquitination processes (K48-linked ubiquitination, autoubiquitination, ubiquitin-dependent protein catabolic process) and their links to immune signaling pathways, notably TNF-mediated and canonical NF-\u03baB signaling, along with IL-17 signaling and T cell regulation. The inclusion of a Wnt receptor catabolic process term also points to proteasomal/receptor turnover control via ubiquitination. Altogether, these terms suggest a cohesive role in ubiquitin-regulated inflammatory and immune responses.","confidence":"High","size":16,"edges":49,"triangles":40,"max_degree":8,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070936","count":3},{"id":"GO:1902187","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0051092","count":3},{"id":"GO:1903883","count":3}]},{"hash":"846498041329526020","title":"Dopaminergic Neuron Signaling and Transcription","description":"The cluster shows a convergence of transcriptional regulation (DNA-templated transcription) with dopaminergic synaptic activity and signaling pathways (AKT/PI3K, serine phosphorylation), along with protein trafficking and nucleus-cytoplasm transport. This points to a cohesive theme of transcriptional control and signaling in dopaminergic neurons, supported by axon development and membrane targeting, with some inflammatory signaling context. Confidence: Medium","confidence":"","size":16,"edges":34,"triangles":30,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0032435","count":5},{"id":"GO:0001963","count":5},{"id":"GO:0033138","count":5},{"id":"GO:0032148","count":5}]},{"hash":"1710999392723821601","title":"Macrophage chemotaxis and MAPK inflammatory signaling","description":"The cluster features strong signals for macrophage chemotaxis and activation (positive regulation of macrophage chemotaxis) along with multiple MAPK pathway regulations (ERK1/ERK2 and JNK cascades) and a cellular response to lipopolysaccharide, all pointing to innate immune and inflammatory signaling in macrophages. Additional terms related to cell-matrix adhesion and antiviral response support a broader, macrophage-centered inflammatory program rather than a single pathway. ","confidence":"High","size":16,"edges":21,"triangles":16,"max_degree":6,"top_function":"wound healing","top_go_terms":[{"id":"GO:0010759","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0090314","count":7},{"id":"GO:0046330","count":7},{"id":"GO:0071222","count":7}]},{"hash":"246407555681495172","title":"Caveolae-mediated signaling and endocytosis","description":"The cluster is enriched for caveola-related terms (caveolin-mediated endocytosis, caveola assembly) alongside diverse signaling pathways (insulin receptor signaling, Wnt, TGF-beta, ERK cascade regulation) and stimuli (prostaglandin E, angiotensin signaling). This suggests a cohesive theme of caveolae-associated signal transduction and endocytic regulation across tissues such as heart and neural contexts.","confidence":"Medium","size":16,"edges":59,"triangles":109,"max_degree":10,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0071380","count":11},{"id":"GO:0008286","count":9},{"id":"GO:0071560","count":9},{"id":"GO:0072584","count":8},{"id":"GO:0086098","count":8}]},{"hash":"215080953053379710","title":"Zinc ion transport and homeostasis","description":"This cluster is dominated by GO terms related to zinc handling\u2014detoxification, intracellular zinc homeostasis, zinc import across membranes, and response to zinc ion conditions\u2014along with cadmium transport, all pointing to a cohesive theme of zinc uptake and regulation. A non-core term for limb development appears, but the zinc-related terms are clearly the strongest signal, justifying a zinc-focused label.","confidence":"High","size":16,"edges":80,"triangles":212,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":10},{"id":"GO:0006882","count":10},{"id":"GO:0070574","count":10},{"id":"GO:0006830","count":9},{"id":"GO:1903615","count":9}]},{"hash":"1987856418848948950","title":"Unknown","description":"The GO terms span a wide range of functions\u2014from biomineral tissue development and blood coagulation to fungal cell wall biosynthesis, muscle contraction, carbohydrate metabolism, glycan processing, and neuromuscular control. This broad mix lacks a single, coherent biological theme that would justify a specific, concise label, suggesting the proteins in this cluster do not share a clear common function based on the provided terms. Confidence in any specific functional label would be low without additional context.","confidence":"","size":16,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031214","count":3},{"id":"GO:0030194","count":3},{"id":"GO:0006685","count":3},{"id":"GO:0070880","count":2},{"id":"GO:0002086","count":2}]},{"hash":"1810750470725086700","title":"Bone morphogenesis and ECM remodeling with angiogenesis","description":"The cluster\u2019s terms cluster around skeletal development and extracellular matrix dynamics: bone morphogenesis, collagen fibril organization, and regulation of osteoblast proliferation, plus positive regulation of angiogenesis. Additional terms on cell-substrate adhesion and xenobiotic response align with ECM interactions and developmental remodeling. While some terms touch on other developmental contexts, the strongest signal is bone formation/remodeling and its vascularization, justifying a skeletal development label.","confidence":"High","size":16,"edges":27,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0071347","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0033689","count":3},{"id":"GO:0010812","count":3}]},{"hash":"781537326515622483","title":"ER\u2013Golgi trafficking and secretion","description":"The top GO terms center on ER-to-Golgi vesicle transport, COPI coating, ER retention, and protein exit from the ER, plus regulation of Wnt secretion, which together define a cohesive secretory pathway function. Some terms related to apoptosis, development, and amyloid-beta formation are less core but can be linked to secretory pathway context.","confidence":"High","size":16,"edges":112,"triangles":457,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0048205","count":4},{"id":"GO:0043652","count":4},{"id":"GO:0009099","count":4},{"id":"GO:0009097","count":4}]},{"hash":"1986249423638293698","title":"Cell cycle control and apoptosis","description":"Most represented terms center on how cells regulate division and fate under stress: mitotic cell cycle and G2 DNA damage checkpoint signaling, apoptosis, and negative regulation of proliferation. Additional signals like cadmium response and innate immunity accompany these core themes, suggesting a cohesive function in cell-cycle control and programmed cell death under stress. Some terms such as visual perception and skeletal muscle development may reflect gene pleiotropy or broader annotations. Overall, this label captures the central pattern in the cluster.","confidence":"Medium","size":16,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006915","count":7},{"id":"GO:0000278","count":5},{"id":"GO:0071276","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0008285","count":4}]},{"hash":"1813346503007129208","title":"Cell Adhesion and ECM Remodeling","description":"The top GO terms cluster around integrin signaling, cell adhesion, extracellular matrix interactions, and regulation of metallopeptidases, which together suggest processes governing cell adhesion and ECM remodeling to drive cell migration. Some outlier terms related to chlorophyll, stamen formation, and visual perception may reflect annotation noise or cross-species annotations, but the dominant theme points to adhesion-mediated signaling and matrix dynamics.","confidence":"Medium","size":16,"edges":113,"triangles":470,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":7},{"id":"GO:0045123","count":6},{"id":"GO:1901202","count":6},{"id":"GO:0048455","count":6},{"id":"GO:0034113","count":6}]},{"hash":"1846562668106740533","title":"RNA processing and ribosome biogenesis","description":"The cluster shows strong representation of RNA processing and ribosome assembly terms: mRNA splicing (via spliceosome), nuclear polyadenylation-dependent mRNA decay, rRNA processing, and ribosomal large subunit biogenesis, with additional transcription regulation by RNA polymerase II, all pointing to coordinated RNA maturation and ribosome production. Some development/chromatin terms appear but are less central to the main signal.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000464","count":16},{"id":"GO:0045944","count":16},{"id":"GO:1904570","count":16},{"id":"GO:0048026","count":16},{"id":"GO:1900050","count":16}]},{"hash":"1574283107313734960","title":"Germ cell development and meiosis","description":"The cluster is dominated by GO terms related to gametogenesis and meiotic processes: oogenesis, spermatogenesis, oocyte growth, female germ-line stem cell maintenance, meiosis chromosome segregation, and germ cell migration. These indicate a shared role in germ cell development and meiotic regulation. A few terms pertain to neural development or synaptic regulation, which may reflect broader roles of some genes or annotation noise, but the core signal points to germ cell and meiotic function.","confidence":"High","size":16,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048477","count":3},{"id":"GO:0007283","count":3},{"id":"GO:0001555","count":2},{"id":"GO:0045886","count":2},{"id":"GO:0036099","count":2}]},{"hash":"1505509982265378484","title":"Vacuolar amino acid transport","description":"This cluster is dominated by GO terms for importing multiple amino acids (proline, glutamine, arginine, histidine, tyrosine) into the vacuole and one for arginine export from the vacuole, indicating a common function in vacuolar amino acid transport and homeostasis. Related terms about transmembrane transport support this theme, while a couple of outliers (root cap development, obsolete terms) are less central to this core function.","confidence":"Medium","size":16,"edges":18,"triangles":4,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":7},{"id":"GO:2000487","count":7},{"id":"GO:0090452","count":7},{"id":"GO:0061402","count":7},{"id":"GO:1901482","count":7}]},{"hash":"2267927527310287730","title":"Golgi-to-PM vesicle trafficking and exocytosis","description":"The cluster is enriched for exocytosis, Golgi-to-plasma-membrane transport, exocyst localization/assembly, Golgi organization, and vesicle tethering in exocytosis, with a plant-specific hint from pollen tube growth, pointing to polarized secretion. This combination strongly suggests roles in vesicle trafficking from the Golgi to the plasma membrane and exocytosis.","confidence":"High","size":16,"edges":93,"triangles":303,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006887","count":6},{"id":"GO:0006893","count":6},{"id":"GO:0051601","count":5},{"id":"GO:0007030","count":4},{"id":"GO:0032258","count":4}]},{"hash":"827269315287506199","title":"Neural development and visual signaling","description":"The cluster is enriched for neural development terms (axonogenesis, substantia nigra development) and regulation of opsin-mediated signaling (visual pathway), with supporting terms like hypoxia response and complement activation that can occur in CNS contexts, suggesting a cohesive set of proteins involved in neural/visual signaling with some stress/immune modulation.","confidence":"Medium","size":16,"edges":10,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008284","count":8},{"id":"GO:0007409","count":7},{"id":"GO:0071456","count":7},{"id":"GO:0097274","count":7},{"id":"GO:0061179","count":7}]},{"hash":"543382955575036592","title":"Developmental morphogenesis and differentiation","description":"This cluster is dominated by GO terms tied to development and organ formation: floor plate development, ascending aorta morphogenesis, comma-shaped body morphogenesis, Malpighian tubule tip cell differentiation, Notch signaling-related heart induction, and negative regulation of osteoblast differentiation. The inclusion of transcription by RNA polymerase II supports gene-expression programs driving development. A few terms (humoral immune response, oxidative stress-induced senescence, leptomycin B response) appear peripheral, but the core theme appears to be developmental morphogenesis and differentiation.","confidence":"Medium","size":16,"edges":26,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0072049","count":15},{"id":"GO:0061382","count":15},{"id":"GO:0072750","count":15},{"id":"GO:0090403","count":15}]},{"hash":"766919756940544166","title":"RNA Splicing and Translation Regulation","description":"The top GO terms indicate both RNA processing (splicing, polyadenylation, mRNA export) and translation control (preinitiation complex formation, initiation factor assembly, miRNA-mediated silencing), suggesting a coherent cluster of proteins coordinating RNA metabolism and translation.","confidence":"High","size":16,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":13},{"id":"GO:0048026","count":13},{"id":"GO:1900363","count":13},{"id":"GO:0031047","count":13},{"id":"GO:0001731","count":13}]},{"hash":"827078804958996864","title":"Ubiquitin\u2011mediated innate immune and TNF signaling","description":"This cluster centers on ubiquitination-related processes (protein autoubiquitination and ubiquitin-dependent protein catabolic process) alongside innate immune responses and TNF signaling pathways (including TNF-mediated signaling and NF-kappaB-related terminology). The presence of terms about intracellular transport of viral material and microtubule localization suggests interplay between ubiquitin-driven regulation and intracellular trafficking in antiviral/immune contexts. Taken together, these terms point to a module of ubiquitin-dependent immune signaling linked to TNF/NF-kappaB pathways.","confidence":"High","size":16,"edges":13,"triangles":1,"max_degree":5,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901253","count":12},{"id":"GO:0051865","count":12},{"id":"GO:0042787","count":12},{"id":"GO:1903762","count":11},{"id":"GO:1903265","count":11}]},{"hash":"1930695239741236188","title":"Adipocyte Differentiation and Hormone Signaling","description":"The terms center on fat cell differentiation and hormone-driven metabolic signaling (growth hormone receptor signaling, insulin-related regulation) with cytoskeletal remodeling (actin bundle assembly) and modulation of inflammatory and apoptotic processes, suggesting a theme of adipocyte development and metabolic regulation. Some terms (heat response, mechanical sensation) may reflect general stress responses but do not dominate the cluster\u2019s core function.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":4},{"id":"GO:0045444","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0010745","count":4},{"id":"GO:0060396","count":3}]},{"hash":"816953470552909337","title":"Development, differentiation, and antigen presentation","description":"This cluster centers on developmental processes (multicellular organism development, chondrocyte and fat cell differentiation, vasculogenesis) and transcriptional regulation, with notable representation of protein ubiquitination and mRNA stability control. The presence of antigen processing/presentation via MHC I links to immune function, suggesting a group of proteins involved in tissue development with immune processing capabilities. While there are some metabolic and host-interaction terms (symbiont entry, insulin signaling regulation), the strongest signal is development/differentiation combined with antigen presentation.","confidence":"Medium","size":16,"edges":50,"triangles":38,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0006351","count":2},{"id":"GO:2001214","count":2},{"id":"GO:0019885","count":2},{"id":"GO:0046718","count":2}]},{"hash":"2151879482992209759","title":"Developmental Patterning and Immune Regulation","description":"Top terms in this cluster point to two related but distinct themes: developmental patterning and organogenesis (left/right pattern formation, somitogenesis, epithelial maturation in prostate development, smooth muscle tissue development) and adaptive immune processes (T follicular helper cell differentiation, germinal center regulation, peripheral T cell tolerance induction). Additional terms like insulin receptor signaling and mitotic G2 DNA damage checkpoint signaling suggest broader growth and cell-cycle control that can accompany development and immune cell maturation. Overall, the cluster seems to reflect a convergence of developmental differentiation with immune signaling. ","confidence":"Medium","size":16,"edges":9,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0001756","count":7},{"id":"GO:0051150","count":7},{"id":"GO:0048745","count":7},{"id":"GO:0060743","count":7}]},{"hash":"1869583089776642948","title":"CNS Development and Dendritic Spine Maintenance","description":"Enriched terms point to CNS development and synaptic regulation, with calcium signaling, MAPK activity, and cytoskeletal control (Rho) supporting dendritic spine maintenance and neural morphogenesis; a few terms (vasculogenesis, apoptotic clearance) are present but secondary.","confidence":"High","size":16,"edges":38,"triangles":43,"max_degree":10,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0043277","count":9},{"id":"GO:2000811","count":8},{"id":"GO:0045123","count":8},{"id":"GO:0007204","count":8},{"id":"GO:0035024","count":8}]},{"hash":"1301985779191178685","title":"Mitochondrial Electron Transport and ATP Synthesis","description":"The cluster is enriched for mitochondrial electron transport chain and oxidative phosphorylation processes: NADH dehydrogenase to ubiquinone, ubiquinol to cytochrome c, proton transmembrane transport, aerobic respiration, and ATP synthesis coupled to electron transport, plus evidence of Complex IV assembly. The presence of a photosynthesis-related term is likely due to cross-reference with energy metabolism in chloroplasts, but the dominant signal points to mitochondrial respiration and ATP production.","confidence":"High","size":16,"edges":83,"triangles":235,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0019684","count":4},{"id":"GO:0006810","count":4},{"id":"GO:0006120","count":3},{"id":"GO:0042773","count":3},{"id":"GO:0030004","count":3}]},{"hash":"2247787607113719026","title":"Cardiac Morphogenesis and Vascular Formation","description":"Several terms point to heart development and morphogenesis (pericardium morphogenesis, cardiac ventricle morphogenesis, cardiac right ventricle formation) and vascular/endothelial differentiation (venous endothelial cell differentiation, glomerular capillary formation, endothelial differentiation regulation). Notch signaling in heart field cardioblast proliferation further supports a cardiac development theme. While some terms are broader (rhombomere boundary formation), the dominant signal is heart and vascular formation, justifying this label.","confidence":"High","size":16,"edges":43,"triangles":42,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0003344","count":15},{"id":"GO:0003208","count":15},{"id":"GO:0032495","count":15},{"id":"GO:0003219","count":15},{"id":"GO:0072104","count":15}]},{"hash":"1582430801236282820","title":"GTPase-Regulated Actin and Membrane Trafficking","description":"These proteins cluster around actin cytoskeleton organization and filopodium dynamics, and are linked to multiple small GTPase pathways (Rab, Rap) that regulate vesicle trafficking (endosome transport; ER-to-Golgi transport). The combination of cytoskeletal remodeling with GTPase-driven vesicle traffic suggests a coherent role in coordinating structural dynamics with membrane transport, spanning contexts such as synaptic plasticity and heart development. ","confidence":"High","size":16,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030036","count":4},{"id":"GO:0090630","count":4},{"id":"GO:0051489","count":3},{"id":"GO:0048227","count":3},{"id":"GO:1902953","count":3}]},{"hash":"474332538015438349","title":"Synaptic Actin Remodeling and Spine Morphogenesis","description":"This cluster is dominated by actin cytoskeleton\u2013related terms (actin organization, filopodium/lamellipodium assembly) and neuronal synapse functions (dendritic spine morphogenesis, synaptic vesicle priming, excitatory postsynaptic potential), with regulatory ties to Rho signaling. Together, they point to actin-driven remodeling and spine development at excitatory synapses, reflecting structural plasticity and synaptic efficiency. Insulin signaling and vascular remodeling terms appear as broader contextual pathways. ","confidence":"High","size":16,"edges":113,"triangles":470,"max_degree":15,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030036","count":13},{"id":"GO:0046847","count":12},{"id":"GO:0008286","count":11},{"id":"GO:0030032","count":11},{"id":"GO:2000463","count":11}]},{"hash":"508999587568623530","title":"Unknown","description":"The Top Terms include both cardiac morphogenesis (outflow tract and left ventricular cardiac muscle tissue development) and a variety of cellular regulatory processes (autophagy, apoptosis inhibition, ubiquitination, miRNA silencing, and antigen processing). This combination lacks a single, cohesive biological theme, making it inappropriate to assign a specific, concise function label. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0050713","count":16},{"id":"GO:0003151","count":16},{"id":"GO:0045345","count":16},{"id":"GO:0051865","count":16},{"id":"GO:2000637","count":16}]},{"hash":"1259420559972183588","title":"Detoxification and DNA Repair Response","description":"This cluster is heavily enriched for detox-related GO terms: xenobiotic catabolic process, glutathione biosynthesis/metabolism, and response to toxic substances, along with nucleotide-excision repair. Together these suggest a coordinated defense against chemical stress and maintenance of genomic integrity. Other terms (auxin signaling, linoleic acid metabolism, translation elongation) appear as ancillary metabolic or regulatory notes but do not contradict the core detox/repair theme.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006808","count":16},{"id":"GO:0042178","count":16},{"id":"GO:0006289","count":16},{"id":"GO:0009636","count":16},{"id":"GO:1901687","count":16}]},{"hash":"1363820908137589041","title":"Ion transport and neuronal signaling","description":"The cluster centers on ion transport (sodium ion transmembrane transport; positive regulation of calcium ion import) and GPCR-mediated signaling related to neural activity, along with sensory processes (light perception) and responses to electrical stimuli, all characteristic of neuronal signaling and energy-dependent transport. While some terms like oocyte maturation and fungicide response are less directly connected, the dominant pattern points to ion flow and signal transduction in neurons and photoreceptors. ","confidence":"Medium","size":16,"edges":73,"triangles":169,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":16},{"id":"GO:0035725","count":16},{"id":"GO:0030818","count":16},{"id":"GO:0060992","count":16},{"id":"GO:0090280","count":16}]},{"hash":"826671040625450256","title":"Unknown","description":"The GO terms are highly diverse and largely non-overlapping (forebrain morphogenesis, vitamin transport, growth regulation, hair follicle maturation, Rho signaling regulation, endocytic recycling, cell-matrix adhesion, observational learning, etc.), with no clear shared pathway or function. The lack of coherent theme and the absence of meaningful connections among terms justify labeling this cluster Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048853","count":1},{"id":"GO:0051180","count":1},{"id":"GO:0040009","count":1},{"id":"GO:0048820","count":1},{"id":"GO:0043942","count":1}]},{"hash":"218364300548294347","title":"Cardiac and neuronal cytoskeletal remodeling and migration","description":"The cluster repeatedly features cytoskeleton- and movement-related GO terms (lamellipodium assembly, Rho signaling regulation, integrin activation, cell migration) along with heart-related terms (heart development, cardiac muscle contraction), and some neuronal spine development terms, suggesting a shared theme of cytoskeletal remodeling governing adhesion and movement in cardiac and neural contexts.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0016477","count":11},{"id":"GO:0007205","count":11},{"id":"GO:2001275","count":10},{"id":"GO:0035023","count":9},{"id":"GO:0016082","count":8}]},{"hash":"1730003185291230157","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0060972","count":1},{"id":"GO:0097552","count":1},{"id":"GO:0007004","count":1},{"id":"GO:0035270","count":1}]},{"hash":"1797179406442113981","title":"Calcium signaling and cytoskeletal remodeling in immune cells","description":"Most terms point to calcium-mediated signaling and actin cytoskeleton remodeling (GO:0050850, GO:0031532), complemented by receptor-mediated signaling (ephrin pathway) and immune cell processes (T and B cell proliferation). The combination suggests a cluster of proteins coordinating calcium signaling with cytoskeletal dynamics in immune-related contexts, with some ER-stress\u2013related translation regulation appearing as a broader stress response. Hence the chosen label.","confidence":"High","size":16,"edges":117,"triangles":520,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0050850","count":16},{"id":"GO:2000251","count":16},{"id":"GO:0031532","count":16},{"id":"GO:1902728","count":16},{"id":"GO:0036493","count":16}]},{"hash":"2141785905055710824","title":"Neural development and axon regeneration with stress signaling","description":"The enriched GO terms cluster around brain development (cerebral cortex, corpus callosum) and neuronal processes like axon regeneration, paired with regulators of apoptosis and stress signaling (ER stress\u2013related apoptosis, JNK cascade). This suggests the proteins function in neural development and neuronal survival under stress, with a few outlier terms (meiotic DSB formation, galactose transcription) that reduce certainty. Overall, the theme is coherent but not perfect. ","confidence":"Medium","size":16,"edges":21,"triangles":6,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":16},{"id":"GO:0070059","count":16},{"id":"GO:0046329","count":16},{"id":"GO:0072428","count":16},{"id":"GO:0021987","count":16}]},{"hash":"1002902660216277659","title":"Post-transcriptional mRNA processing and silencing","description":"The cluster centers on RNA-level regulation after transcription: mRNA stability, alternative splicing, splicing regulation, polyadenylation, mRNA export, and miRNA- or ncRNA-mediated gene silencing, plus components involved in translation initiation. This combination points to coordinated control of mRNA fate and translation rather than transcriptional regulation alone.","confidence":"High","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":15},{"id":"GO:0006378","count":14},{"id":"GO:0000381","count":13},{"id":"GO:0048026","count":13},{"id":"GO:1900363","count":13}]},{"hash":"370983240754591144","title":"Ribosome Biogenesis and rRNA Processing","description":"The top GO terms point to maturation and assembly steps for ribosomal RNA and ribosomal subunits (5.8S, LSU/SSU rRNA, preribosome assembly), indicating a cohesive ribosome biogenesis module. A secondary signal from spliceosomal disassembly and a couple of developmental/regulatory terms may reflect broader RNA processing contexts or annotation overlap, but the dominant pattern is ribosome assembly and rRNA maturation.","confidence":"High","size":16,"edges":107,"triangles":403,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":4},{"id":"GO:0000466","count":3},{"id":"GO:1902626","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0000390","count":3}]},{"hash":"2134567477338857442","title":"Vertebrate embryonic neural-vascular development with adhesion","description":"This cluster highlights several embryonic development processes tied to neural and vascular morphogenesis: neural tube closure, notochord formation, retinal ganglion axon guidance, sprouting angiogenesis, and cell migration, all linked to heterophilic cell-cell adhesion and membrane localization. GPCR internalization also fits into signaling and trafficking during development. While a few immune-related terms appear, the dominant theme is vertebrate embryonic neural-vascular development governed by adhesion and signaling. ","confidence":"High","size":16,"edges":11,"triangles":0,"max_degree":4,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007157","count":4},{"id":"GO:0072661","count":3},{"id":"GO:0014028","count":3},{"id":"GO:0002042","count":3},{"id":"GO:0001843","count":3}]},{"hash":"2052478778988828291","title":"Circadian transcription and xenobiotic response","description":"The top GO terms center on transcription by RNA polymerase II and circadian regulation of gene expression, together with response to xenobiotic stimulus, signaling a cluster of proteins involved in controlling gene expression in response to circadian and chemical stress. Other terms point to broader stress or development contexts, but the dominant theme is transcriptional regulation linked to circadian and xenobiotic cues.","confidence":"Medium","size":16,"edges":20,"triangles":10,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0009410","count":12},{"id":"GO:0032922","count":12},{"id":"GO:0072049","count":11},{"id":"GO:0061382","count":11}]},{"hash":"2040648100688559353","title":"Cell-cycle\u2013regulated vesicle trafficking and protein turnover","description":"This cluster centers on cell cycle control and protein degradation (DNA-templated transcription; regulation of cell cycle; SCF-mediated ubiquitin-dependent proteolysis; cyclin-dependent kinase activity), and on vesicle trafficking and actin dynamics (Arp2/3-mediated actin nucleation; regulation of vesicle fusion; vesicle transport between plasma membrane, endosomes, ER, and Golgi; positive regulation of GTPase activity). Together these terms point to coordinated regulation of protein turnover and intracellular transport during cell cycle progression, giving a cohesive functional theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0007050","count":2},{"id":"GO:0034314","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1724478814611836867","title":"Glycosylation and ganglioside biosynthesis","description":"The top GO terms are dominated by glycosylation-related processes: glycosylceramide metabolic process, oligosaccharide metabolic process, ganglioside biosynthetic process, N-acetylneuraminate metabolic process, and protein sialylation. This suggests the proteins in this cluster are collectively involved in glycan assembly and modification, including glycosphingolipid and protein glycosylation pathways. Some terms related to pollen and olfactory development appear, but the clearest common theme is glycosylation and glycosphingolipid biosynthesis, indicating a functional grouping around glycan metabolism. Confidence: High","confidence":"","size":16,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006677","count":6},{"id":"GO:0009311","count":6},{"id":"GO:0001574","count":6},{"id":"GO:0009860","count":6},{"id":"GO:0021628","count":6}]},{"hash":"556333838371803558","title":"Mammary gland epithelial proliferation and lactation","description":"The cluster is characterized by GO terms strongly tied to mammary biology, including mammary gland epithelial cell proliferation and lactation, along with cell division and re-entry into the mitotic cell cycle. Additional terms like regulation of cyclin-dependent kinase activity and insulin receptor signaling point to growth and metabolic regulation during lactation, while the ER unfolded protein response aligns with the high secretory demand of lactating mammary tissue. Altogether, these terms converge on a theme of proliferative mammary epithelium supporting milk production.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0030968","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0000320","count":3},{"id":"GO:0033598","count":3}]},{"hash":"186118628767117957","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"Proteins in this cluster are enriched for actin-related processes: regulation of cell shape, actin filament network formation, and formin-nucleated actin cable assembly, plus membrane localization and cell migration terms. The additional spindle assembly and ER polarization terms point to broader cytoskeletal dynamics driving polarity and division, making actin-driven remodeling the unifying theme. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008360","count":3},{"id":"GO:0072661","count":2},{"id":"GO:0051225","count":2},{"id":"GO:2000251","count":2},{"id":"GO:0051639","count":2}]},{"hash":"1020387451719524104","title":"NLRP3 inflammasome\u2013IL-1\u03b2 innate immunity","description":"The cluster is driven by GO terms centered on antiviral defense and inflammasome signaling: defense response to virus, interleukin-1 beta production, and positive regulation of NLRP3 inflammasome complex assembly, indicating innate immune activation. Additional terms related to neuronal processes appear with low frequency, suggesting these proteins are primarily linked to inflammasome/cytokine signaling rather than synaptic function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0050702","count":2},{"id":"GO:1900227","count":2},{"id":"GO:0008360","count":2},{"id":"GO:0007269","count":1}]},{"hash":"2114127743594747277","title":"Tissue Morphogenesis and Differentiation","description":"This cluster centers on developmental processes across various tissues\u2014floor plate development, ascending aorta morphogenesis, comma-shaped body morphogenesis, and Malpighian tubule tip cell differentiation\u2014suggesting a common theme of tissue formation and differentiation. Some terms (immune response, senescence, stress signaling) are peripheral, but the core function points to morphogenesis.","confidence":"Medium","size":16,"edges":75,"triangles":167,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0072049","count":12},{"id":"GO:0061382","count":12},{"id":"GO:0072750","count":12},{"id":"GO:0090403","count":12}]},{"hash":"591088759794432014","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0050427","count":2},{"id":"GO:0006044","count":2},{"id":"GO:1904887","count":2},{"id":"GO:0071287","count":2}]},{"hash":"891022167657546100","title":"Unknown","description":"The top GO terms cover endocrine regulation, immune response, reproductive development, neural development, eye development, and protein turnover, with no single cohesive biological theme across the cluster. This makes a concise, meaningful label difficult, so Unknown is most appropriate.","confidence":"","size":16,"edges":8,"triangles":0,"max_degree":5,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0002018","count":5},{"id":"GO:0032496","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0060385","count":4},{"id":"GO:0007413","count":4}]},{"hash":"1242547062507866127","title":"Methylation and lipid biosynthesis cluster","description":"These proteins show a clear enrichment for methylation-related processes, including mRNA capping, tRNA methylation, and various forms of arginine/histone methylation, alongside lipid biosynthesis pathways such as phosphatidylcholine and sterol biosynthesis. While other terms like ribosomal subunit export, nodulation, and cellular senescence appear, the common thread appears to be methyltransferase- and methylation-associated activities intersecting with lipid/metabolic biosynthesis. Overall, the label reflects the most coherent functional theme across the top GO terms, with some annotation noise from related processes.","confidence":"Medium","size":16,"edges":30,"triangles":17,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":2},{"id":"GO:0016126","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0000056","count":2},{"id":"GO:0043985","count":2}]},{"hash":"573388924679566689","title":"Fertilization and Developmental Signaling","description":"This cluster centers on reproductive biology and development: sperm-zona pellucida binding, polyspermy prevention, GnRH signaling, and development-related processes like atrioventricular canal morphogenesis, all hinting at adhesion and signaling events that connect fertilization to embryonic development. Some sensory and immune-related terms are present but seem ancillary to the core reproductive/developmental theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0097211","count":4},{"id":"GO:0042102","count":3},{"id":"GO:0040005","count":3}]},{"hash":"238368788038881398","title":"NOD1/2-TLR4 Innate Signaling","description":"Strong enrichment around pattern-recognition receptor pathways (NOD1/2, TLR4), innate immune response, and inflammatory outputs (IL-8 production, defense against Gram-positive bacteria, dsRNA response), indicating a cohesive NOD/TLR-driven innate immune signaling module. Some vesicle trafficking and mechanical stimulus terms likely reflect receptor signaling context.","confidence":"High","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070427","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1174763580581658209","title":"Developmental Lipid Metabolism","description":"Top GO terms indicate a developmental focus with liver, adipose, and brain development, alongside lipid and energy-related processes (ketone body biosynthesis, cholesterol transport, starvation response). The presence of a few prokaryotic terms (sporulation, PHB biosynthesis) likely reflects annotation noise or broad cross-species metabolic links rather than a single unified function. Overall, the cluster seems best described as Developmental Lipid Metabolism.","confidence":"Medium","size":16,"edges":105,"triangles":390,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0046951","count":8},{"id":"GO:0001889","count":8},{"id":"GO:0042594","count":8},{"id":"GO:0032385","count":7},{"id":"GO:0006550","count":7}]},{"hash":"1609687511363328411","title":"Vertebrate organogenesis and lineage differentiation","description":"The top GO terms point to transcriptional regulation alongside diverse developmental processes across multiple tissues (heart valve formation, floor plate and somitogenesis in neural/axial development, lung vasculature, amacrine retina cells, macrophage differentiation). This pattern suggests a cluster enriched for genes involved in embryonic organogenesis and cell fate specification across lineages, rather than a single pathway. ","confidence":"Medium","size":16,"edges":74,"triangles":169,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0060217","count":6},{"id":"GO:0003199","count":6},{"id":"GO:0033504","count":6},{"id":"GO:0043433","count":6}]},{"hash":"279879633001123886","title":"Mitochondrial translation and Complex IV assembly","description":"The top GO terms center on mitochondrial gene expression and respiration: mitochondrial translation and translation, RNA modification in mitochondria, and assembly of the mitochondrial respiratory chain complex IV, with an additional hint of apoptosis regulation via cytochrome c release. This combination suggests a cohesive cluster of proteins involved in mitochondrial RNA processing/translation and respiratory chain assembly.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0033617","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0090200","count":2},{"id":"GO:0016554","count":1}]},{"hash":"454432796107443317","title":"Mitochondrial outer membrane import complex assembly","description":"The cluster is dominated by GO terms related to the mitochondrial outer membrane and its translocase/import machinery (outer mitochondrial membrane organization; mitochondrial outer membrane translocase complex assembly), indicating a coherent theme around mitochondrial protein import and membrane organization. Other terms are sparse or obsolete and don't override this central signal.","confidence":"High","size":16,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070096","count":1},{"id":"GO:0007008","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0006061","count":1},{"id":"GO:0000122","count":1}]},{"hash":"1632619265361631507","title":"Glycosphingolipid Metabolism and Glycosylation","description":"The top GO terms center on lipid and glycan processing, including glycosylceramide and ganglioside biosynthesis, oligosaccharide metabolism, and N-linked glycosylation, plus lipid catabolic activity. While a few terms relate to pollen or olfactory development, the predominant theme is glycan-lipid remodeling and glycoprotein maturation, suggesting a cluster of proteins involved in glycolipid and glycan processing. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016042","count":2},{"id":"GO:0006677","count":2},{"id":"GO:0009311","count":2},{"id":"GO:0001574","count":2},{"id":"GO:0009860","count":2}]},{"hash":"1992832441740551287","title":"Embryonic Patterning and Mesodermal Development","description":"The top GO terms point to developmental patterning (left/right pattern formation) and broad embryonic tissue formation across mesoderm, cartilage, placenta/trophoblast, and pancreas development, indicating a cluster of proteins involved in early developmental programs and lineage specification rather than a single pathway.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0060806","count":14},{"id":"GO:0060536","count":14},{"id":"GO:0060707","count":14}]},{"hash":"2233646958438608665","title":"Embryonic Organ Morphogenesis","description":"These proteins are enriched for GO terms centered on organogenesis and morphogenesis across multiple tissues (heart, limb, eye, gonad, placenta, brain habenula). The common theme is embryonic development and formation of organs, suggesting a role in morphogenetic processes rather than a single tissue-specific function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0035116","count":8},{"id":"GO:0008584","count":8},{"id":"GO:0003148","count":8},{"id":"GO:0048048","count":8}]},{"hash":"2037283835028026428","title":"Neural signaling and synapse organization","description":"The top terms cluster around neural processes: transmission of nerve impulses, synapse organization, and brain development, with supporting signals in sensory perception and general signal transduction (PI3K/STAT pathways). This suggests the proteins group into neural signaling and synaptic assembly functions, with some development-related roles.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":5},{"id":"GO:0019226","count":5},{"id":"GO:0001580","count":5},{"id":"GO:0001759","count":4},{"id":"GO:0002327","count":4}]},{"hash":"1867554462353859740","title":"Innate Immunity and Barrier-Calcium Transport","description":"This cluster features immune-related terms (innate immune response, defense against bacterium, immunoglobulin production) alongside barrier-related processes (septate junction assembly, establishment of glial blood-brain barrier, regulation of tube size) and calcium handling (calcium ion transport, SR calcium transport). The mix suggests a theme around barrier integrity and calcium signaling that can intersect with immune functions, though the connection is not tightly cohesive across all terms. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0002377","count":2},{"id":"GO:0019991","count":2},{"id":"GO:0034765","count":2},{"id":"GO:0070588","count":2}]},{"hash":"83316572614649473","title":"Host Immune and Stress Response","description":"The GO terms cluster around immune and inflammatory signaling (acute-phase response, positive regulation of IL-4 production), host\u2013pathogen interaction (symbiont entry into host cell), cellular stress and injury responses (response to hypoxia, apoptotic process, response to axon injury), and developmental/neural processes (embryo implantation, regulation of synapse assembly). The terms span related, but diverse processes, and there are no edges among proteins, so this label serves as a broad, representative theme rather than a tightly connected functional module.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0051963","count":4},{"id":"GO:0010951","count":4},{"id":"GO:0001666","count":3},{"id":"GO:0007566","count":3}]},{"hash":"450196714573618475","title":"Embryonic organ and nervous system development","description":"Most top GO terms describe development of multiple organs and nervous system components during embryogenesis (kidney ureteric bud morphogenesis, endocrine pancreas, inner ear, pituitary, hypothalamus, digestive tract) and neural lineage specification/migration (ventral spinal cord interneurons, neural crest). A concurrent term on transcriptional regulation by RNA polymerase II supports regulatory control during development. Together, these terms point to a broad embryonic developmental program across diverse tissues, justifying a label centered on embryonic organ and nervous system development.","confidence":"High","size":16,"edges":28,"triangles":20,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0090190","count":16},{"id":"GO:0031018","count":16},{"id":"GO:0000122","count":16},{"id":"GO:0048839","count":16},{"id":"GO:0021983","count":16}]},{"hash":"1353115778867715083","title":"Nervous system development and axon guidance","description":"The cluster is dominated by GO terms tied to nervous system development, neuron projection development, and peripheral nervous system development, along with signaling pathways (Slit-Robo, Hedgehog, BMP) and processes like myelination and cell\u2013cell adhesion. These collectively point to a coherent theme of neural development and axon guidance, with associated glial maturation, rather than a single metabolic or cellular process.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021740","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0035385","count":2},{"id":"GO:0045663","count":2}]},{"hash":"1160914823957338074","title":"LPS-Triggered Inflammation and Lipid Metabolism","description":"The top GO terms include response to lipopolysaccharide, prostaglandin metabolic process, fatty acid omega-oxidation, and nitrosative stress response, plus extracellular regulation of signal transduction. This pattern points to a cluster of proteins tied to innate immune response to bacterial components and lipid mediator signaling, with supporting detoxification and redox regulation activities. The shared theme centers on LPS-induced inflammation and lipid metabolism pathways.","confidence":"High","size":15,"edges":76,"triangles":256,"max_degree":12,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0032496","count":12},{"id":"GO:0006069","count":12},{"id":"GO:0019518","count":12},{"id":"GO:0010430","count":12},{"id":"GO:0045777","count":12}]},{"hash":"2069697315460615396","title":"Angiogenesis with ECM remodeling and immune signaling","description":"The top GO terms point to blood vessel formation (angiogenesis) and signaling via the ERK cascade, coupled with processes like cell-surface localization and cell-matrix adhesion, which are key in endothelial interactions during vessel formation. The presence of adaptive immune response and interleukin-1\u2013related cellular responses, along with heparin proteoglycan biosynthesis and fibrinolysis, indicates extracellular matrix remodeling and inflammatory vascular regulation. Together, these terms suggest a cohesive cluster centered on vascular development, ECM remodeling, and immune-associated signaling.","confidence":"Medium","size":15,"edges":9,"triangles":2,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0034394","count":8},{"id":"GO:0002250","count":7},{"id":"GO:0050928","count":6}]},{"hash":"1758303890059341030","title":"ER-Golgi trafficking and secretion","description":"This cluster is dominated by GO terms related to endoplasmic reticulum to Golgi vesicle transport and its regulation, plus related steps like ER exit and lumen retention, with Wnt secretion supporting a secretory pathway role; while some developmental terms appear, they can be linked to secretory trafficking processes, making the ER-to-Golgi transport theme most representative.","confidence":"High","size":15,"edges":72,"triangles":169,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0060628","count":2},{"id":"GO:0060576","count":2},{"id":"GO:0040027","count":1},{"id":"GO:0006621","count":1}]},{"hash":"376819864766832240","title":"Lipid biosynthesis and immune signaling","description":"The top GO terms cluster around lipid metabolism (triglyceride biosynthesis, CDP-diacylglycerol biosynthesis, phosphatidylcholine remodeling, platelet activating factor biosynthesis) and immune regulation (interleukin-2 production, negative regulation of activation-induced T cell death). While there are developmental and energy-production terms as well, the most prominent shared theme is lipid biosynthesis coupled with lipid-mediated modulation of immune processes. This makes the label a concise reflection of the cluster\u2019s core functions.","confidence":"Medium","size":15,"edges":92,"triangles":326,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":8},{"id":"GO:0016024","count":6},{"id":"GO:0070970","count":6},{"id":"GO:0070236","count":6},{"id":"GO:0042775","count":6}]},{"hash":"2043510084791829952","title":"Mitochondrial Protein Import and Respiratory Chain Assembly","description":"The cluster shows strong enrichment for terms related to importing proteins into the mitochondrial matrix and inner membrane, plus chloroplast stroma import, and assembly of the mitochondrial respiratory chain (Complex IV) and aerobic respiration. This points to a cohesive role in organelle protein targeting and energy metabolism, justifying the label.","confidence":"High","size":15,"edges":101,"triangles":405,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":4},{"id":"GO:0030150","count":4},{"id":"GO:0045039","count":4},{"id":"GO:0045037","count":4},{"id":"GO:0000002","count":4}]},{"hash":"413772705017263468","title":"Mitochondrial and vacuolar membrane targeting and ion transport","description":"These terms point to proteins involved in targeting to mitochondria and vacuoles, insertion into the inner mitochondrial membrane, and proton/ion transport driving organelle function (vacuolar acidification, sodium transport, proton motive force). The shared theme is membrane trafficking and ion homeostasis across organellar membranes, supporting a cohesive label.","confidence":"High","size":15,"edges":90,"triangles":340,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":5},{"id":"GO:0045039","count":4},{"id":"GO:0015991","count":3},{"id":"GO:0007035","count":3},{"id":"GO:0072321","count":2}]},{"hash":"408165128547410141","title":"Adaptive Immune Signaling and B Cell Activation","description":"Most terms point to adaptive immunity: IL-2 production, B cell receptor signaling, adaptive immune response, and innate immune response, with additional terms related to immune cell adhesion and signaling pathways (Rho signaling). Some terms (e.g., heart development) may be pleiotropic or less specific, but the overall theme is immune activation and communication among immune cells. Thus this cluster appears to represent proteins involved in adaptive immune signaling and B cell\u2013mediated responses.","confidence":"High","size":15,"edges":6,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900042","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0014068","count":6}]},{"hash":"228304996807253293","title":"Leukocyte adhesion and migration","description":"The GO terms cluster around integrin-mediated signaling, cell adhesion, extravasation, and substrate-dependent migration, plus immune activation (T cell receptor\u2013MHC\u2013mediated activation) and chemokine regulation, which together define leukocyte trafficking and recruitment to sites, including ECM remodeling aspects. Some terms (e.g., auditory development) appear as noise relative to the dominant immune cell\u2013migration theme.","confidence":"High","size":15,"edges":36,"triangles":36,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0045123","count":4},{"id":"GO:0034113","count":4},{"id":"GO:0006929","count":4},{"id":"GO:0035987","count":4}]},{"hash":"1949658159700139562","title":"Synaptic vesicle release and plasticity","description":"The top GO terms cluster around presynaptic vesicle fusion (SNARE complex assembly), neurotransmitter release, and short-term synaptic plasticity, along with regulation of synapse assembly and plasticity. These consistently point to proteins coordinating synaptic transmission and its rapid modulation, with additional signals like sleep and histamine secretion reflecting broader neuromodulatory context but not changing the core theme.","confidence":"High","size":15,"edges":21,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0031629","count":1},{"id":"GO:0002553","count":1},{"id":"GO:0030431","count":1},{"id":"GO:0099590","count":1},{"id":"GO:0035493","count":1}]},{"hash":"2028830056218542115","title":"DNA Damage Response and Ubiquitin Regulation","description":"This cluster centers on nuclear processes tied to genome integrity (DNA-templated transcription, mRNA processing, meiotic cell cycle, DNA damage checkpoint signaling, ionizing radiation response) and on ubiquitin-mediated protein turnover (ubiquitination and deubiquitination, including K6- and K29-linked). The ERAD-related term also points to protein quality control under stress. Together, they suggest a coherent theme of DNA damage response coupled with ubiquitin-dependent regulation of protein homeostasis.","confidence":"High","size":15,"edges":18,"triangles":6,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0044313","count":2},{"id":"GO:1904378","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0035523","count":2}]},{"hash":"404164261105054545","title":"Organ morphogenesis and sensory development","description":"This cluster is driven by organ morphogenesis and sensory development, notably retina/eye, brain, digit, and bronchus formation, with a broader theme of tissue development and ciliary receptor localization; immune phagocytosis terms appear but are peripheral.","confidence":"Medium","size":15,"edges":62,"triangles":98,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0050766","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0050908","count":3},{"id":"GO:0060041","count":3}]},{"hash":"1961915892663696582","title":"Interferon signaling and dendritic cell differentiation","description":"The cluster is enriched for immune-related GO terms, notably positive regulation of interferon-alpha and interferon-beta production, defense response to protozoan, cellular response to interleukin-4, and myeloid dendritic cell differentiation. These point to interferon-driven immune signaling and dendritic cell biology as the core theme, with some transcriptional regulation terms accompanying. A few developmental terms (lung/pancreas-related) appear secondary but do not override the dominant immune-centric signal.","confidence":"High","size":15,"edges":86,"triangles":259,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0071353","count":6},{"id":"GO:0031018","count":5},{"id":"GO:0043011","count":4},{"id":"GO:0043388","count":4}]},{"hash":"322558392067280335","title":"Rho/Rac/Ras-regulated actin dynamics in immune cells","description":"The cluster is dominated by GO terms for small GTPase signaling (Rho, Rac, Ras), lamellipodium assembly, and actin cytoskeleton organization, with immune-related processes such as B cell maturation, NK T cell differentiation, and interleukin signaling, indicating a shared theme of cytoskeletal remodeling driven by GTPase pathways during immune cell activation.","confidence":"High","size":15,"edges":84,"triangles":242,"max_degree":14,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":12},{"id":"GO:0046580","count":10},{"id":"GO:0098761","count":9},{"id":"GO:0007264","count":9},{"id":"GO:0030032","count":9}]},{"hash":"1779403632487769489","title":"Neuronal secretory granules and synaptic regulation","description":"The cluster\u2019s GO terms point to neuronal secretory and synaptic processes: dense core granule maturation, monoamine transport, and regulation of neurotransmitter secretion, along with dendritic spine maintenance and long-term synaptic depression. The Arp2/3 actin-nucleation regulation ties into synaptic actin remodeling, reinforcing a theme of vesicle trafficking and synaptic function in neurons. A single term on chromatin assembly is present but does not define the cluster\u2019s main theme.","confidence":"High","size":15,"edges":32,"triangles":18,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0032418","count":2},{"id":"GO:0050796","count":1},{"id":"GO:0007205","count":1},{"id":"GO:0046928","count":1},{"id":"GO:0097062","count":1}]},{"hash":"2115579444967836300","title":"Cell cycle progression and centrosome regulation","description":"The cluster is dominated by GO terms tied to cell division and centrosome function (mitotic cell cycle, cell cycle, maintenance of centrosome location, negative regulation of asymmetric cell division, DNA recombination, ubiquitination). While also including endosome-to-lysosome transport and phosphatidic acid biosynthesis, these likely reflect membrane and lipid signaling processes that accompany cell cycle\u2013driven remodeling. Together they point to a cohesive theme of cell cycle control with centrosome regulation.","confidence":"Medium","size":15,"edges":29,"triangles":17,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0021873","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1182641366376819415","title":"Innate antiviral transcriptional response","description":"This cluster is enriched for GO terms related to innate immunity, defense against virus, and type I interferon response, complemented by transcription initiation and chromatin remodeling terms. The combination suggests involvement in sensing/signaling antiviral defenses and coordinating antiviral gene expression via transcriptional regulation. Some unrelated terms appear at lower counts, likely annotation noise; overall the dominant signal is antiviral immune transcription.","confidence":"High","size":15,"edges":7,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0048096","count":5},{"id":"GO:0006351","count":4},{"id":"GO:1903070","count":3},{"id":"GO:0051607","count":3}]},{"hash":"852814741462130681","title":"Neural development and cadherin-mediated adhesion","description":"The cluster is enriched for cadherin-based cell adhesion and neural development terms (synaptic transmission and serotonergic/dopaminergic axon guidance), suggesting a theme of neural connectivity and adhesion; the other terms (nephron development, bone maturation, lung branching morphogenesis) may reflect broader developmental programs.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007268","count":7},{"id":"GO:0072006","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0007605","count":6}]},{"hash":"170378579409974896","title":"Glycosphingolipid Metabolism and Sialylation","description":"The top GO terms point to glycosylation-related processes: glycosylceramide metabolism, oligosaccharide metabolism, ganglioside biosynthesis, N-linked glycosylation, and protein sialylation, indicating a cohesive theme around glycan modification and sphingolipid biosynthesis. While a few terms touch on pollen or olfactory development, the shared signal is glycosylation/sialylation pathways modifying lipids and proteins. This label best captures the core function represented by the cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006677","count":3},{"id":"GO:0009311","count":3},{"id":"GO:0001574","count":3},{"id":"GO:0009860","count":3},{"id":"GO:0021628","count":3}]},{"hash":"1858252061297014589","title":"Actin Cytoskeleton Regulation and Motility","description":"The cluster is enriched for actin dynamics and cytoskeletal organization (positive regulation of actin filament depolymerization, sarcomere organization) and Rac signaling, plus features related to cell motility control and growth. This points to coordinated cytoskeletal remodeling and signaling-driven regulation of cell movement, with supporting IGF and IL-1\u2013related responses.","confidence":"High","size":15,"edges":36,"triangles":26,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030836","count":4},{"id":"GO:1904783","count":3},{"id":"GO:1990314","count":3},{"id":"GO:0071347","count":3},{"id":"GO:0010643","count":3}]},{"hash":"48345077535804869","title":"Neuronal Development and Apoptosis Signaling","description":"The cluster centers on neural development terms (hippocampus development, neuron development, neurotrophin receptor signaling) and apoptotic processes (neuron/glial apoptosis, extrinsic apoptotic signaling, response to hypoxia), suggesting proteins involved in neural development and stress-induced cell death pathways. Some terms like heart development are peripheral, but the dominant theme is CNS development with apoptosis signaling.","confidence":"Medium","size":15,"edges":88,"triangles":311,"max_degree":14,"top_function":"wound healing","top_go_terms":[{"id":"GO:0051092","count":12},{"id":"GO:0048011","count":11},{"id":"GO:0008635","count":10},{"id":"GO:0021766","count":10},{"id":"GO:0045736","count":10}]},{"hash":"1500244985186423022","title":"Cartilage and Bone Differentiation with BMP Signaling","description":"These proteins show a strong enrichment for chondrogenesis and cartilage development terms (cartilage condensation, chondrocyte differentiation, cartilage development) alongside osteoblast differentiation and BMP signaling, pointing to a shared role in cartilage formation and subsequent bone formation. The presence of endothelial activation and labyrinthine layer blood vessel development suggests coordinated vascular remodeling during this tissue formation, while cell-matrix adhesion and stress fiber assembly reflect matrix remodeling and cytoskeletal changes typical of developing cartilage and bone. Overall, this cluster centers on cartilage formation with BMP-driven bone differentiation and associated vascular dynamics.","confidence":"High","size":15,"edges":102,"triangles":419,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042118","count":13},{"id":"GO:0007160","count":13},{"id":"GO:0030513","count":13},{"id":"GO:1902731","count":12},{"id":"GO:0001502","count":12}]},{"hash":"1264123857036442962","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":40,"triangles":25,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070814","count":5},{"id":"GO:0009636","count":5},{"id":"GO:0044205","count":5},{"id":"GO:0019344","count":4},{"id":"GO:0014740","count":4}]},{"hash":"673978978709342227","title":"TNF/NF-\u03baB inflammatory signaling and apoptosis regulation","description":"The prominent GO terms point to TNF-mediated signaling, canonical NF-kappaB activation, and the JNK cascade, along with protein autoubiquitination and regulation of apoptotic processes. While a V(D)J recombination term and some obsolete entries appear, the shared theme is a TNF/NF-\u03baB\u2013centered signaling module governing inflammation and cell fate.","confidence":"High","size":15,"edges":4,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":10},{"id":"GO:1903265","count":10},{"id":"GO:0033209","count":10},{"id":"GO:0090073","count":9},{"id":"GO:0033151","count":9}]},{"hash":"1977865977907451183","title":"Cardiac stress signaling and morphogenesis","description":"The top GO terms indicate oxidative and heat stress responses, along with activation of stress-activated MAPK signaling. There is specific mention of ventricular cardiac muscle tissue morphogenesis and regulation of calcium-release channels, plus cytoskeletal dynamics and protein stabilization, suggesting a cluster of proteins involved in stress responses that influence cardiac development and calcium signaling, with associated cytoskeletal remodeling. Overall, the terms point to a cardiac-related stress signaling and morphogenesis theme.","confidence":"Medium","size":15,"edges":20,"triangles":17,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042542","count":7},{"id":"GO:0009408","count":5},{"id":"GO:0055010","count":5},{"id":"GO:0060315","count":5},{"id":"GO:0030308","count":4}]},{"hash":"142006563041786376","title":"Neuronal signaling and photoreception","description":"The proteins appear tied to neural communication and light-sensing: ion transport (sodium and calcium), GPCR-PLC signaling, and energy metabolism (electron transport chain) support neuronal activity; terms for light detection and memory point to photoreceptive and cognitive neural functions. Some outliers (oocyte maturation regulation, fungicide response) exist, but the dominant theme is neural signaling and vision-related processes.","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":15},{"id":"GO:0035725","count":15},{"id":"GO:0030818","count":15},{"id":"GO:0060992","count":15},{"id":"GO:0090280","count":15}]},{"hash":"1654933501760942189","title":"Lens Development in the Camera-Type Eye","description":"The cluster is dominated by GO terms related to lens fiber cell morphogenesis, differentiation, and development, along with broader camera-type eye development and lens development terms, indicating a cohesive lens/eye morphogenesis function. A few terms like left/right pattern formation and mesoderm development appear but are secondary, supporting the central lens-eye theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":9},{"id":"GO:0070309","count":8},{"id":"GO:0070306","count":8},{"id":"GO:0070307","count":8},{"id":"GO:0002009","count":8}]},{"hash":"1743979466563645184","title":"Synaptic Organization and AMPA Receptor Regulation","description":"The dominant GO terms point to synaptic structure and glutamatergic signaling, with postsynaptic density clustering, postsynaptic membrane assembly, regulation of terminal button organization, and positive regulation of AMPA receptor activity\u2014core features of synapse formation and function. Other terms about neural development (retina) and unrelated metabolism appear as outliers, but do not override the central synaptic theme. Therefore, the cluster is best described as focused on synaptic organization and AMPA receptor regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006695","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0019695","count":4},{"id":"GO:2000331","count":4},{"id":"GO:0097119","count":4}]},{"hash":"1496491166696597977","title":"Cadherin-Mediated Adhesion and Neural Development","description":"Top GO terms are dominated by cadherin-related cell\u2013cell adhesion (homophilic/heterophilic and cadherin-mediated) and neural development processes, including nervous system development, synapse assembly, and sensory perception of sound. While terms for ossification and blood vessel maturation appear, the central theme is cadherin-based adhesion guiding neural differentiation and connectivity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0043931","count":12},{"id":"GO:0051965","count":12},{"id":"GO:0001955","count":12}]},{"hash":"692205740603650725","title":"Immune Development and Epithelial Morphogenesis","description":"The proteins show enrichment for both immune system processes (adaptive and innate immune responses) and developmental/morphogenesis terms (multicellular organism development, morphogenesis of an epithelium), with supporting signals related to secretion, estrogen response, and epithelial dynamics. This suggests a cluster spanning immune signaling and epithelial development, rather than a single narrow function. ","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0043627","count":2}]},{"hash":"2040222799486790931","title":"Neuromuscular Cytoskeletal Remodeling","description":"This cluster centers on actin-mediated cytoskeleton dynamics (actin filament network formation, microspike assembly, Rho signaling) and tissue morphogenesis across neural and muscular contexts, including sarcomere organization, Purkinje cell layer morphogenesis, and olfactory nerve organization, suggesting a shared theme of cytoskeletal remodeling driving neuromuscular development and neural tissue architecture.","confidence":"Medium","size":15,"edges":48,"triangles":33,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0061368","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0051639","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0030035","count":3}]},{"hash":"1086117199588884920","title":"Heart and skeletal development","description":"This cluster is dominated by GO terms related to cardiovascular and skeletal formation, including heart development, cartilage development and endochondral bone morphogenesis, and ossification. These indicate a shared theme of vertebrate organ and structural development. While there are additional terms like melanocyte differentiation, hormone secretion regulation, and immune-related complement activation that are less cohesive with the core theme, the primary signal points to heart and bone/ cartilage formation. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0051966","count":2}]},{"hash":"1131218831252848733","title":"Heart development and smooth muscle differentiation","description":"The top GO terms cluster around cardiovascular morphogenesis: smooth muscle tissue development, endocardial cushion\u2013related migration, vascular smooth muscle differentiation, and cell\u2013matrix/cell\u2013cell adhesion. While a few terms (e.g., amelogenesis, symbiont entry) seem less connected, the dominant theme is heart/vessel development and adhesion. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048745","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0003273","count":3},{"id":"GO:0007160","count":3}]},{"hash":"35881490275000624","title":"Complement-Driven Proteolysis and Development","description":"This cluster centers on proteolytic and signaling processes that span immune response (complement activation) and tissue remodeling (plasminogen activation, angiogenesis), with several development-related terms (pancreas morphogenesis, post-embryonic development, multicellular growth) suggesting a broader role in growth and morphogenesis. The connection across proteolysis, immune activation, and developmental remodeling supports a unifying theme around proteolytic regulation in development and vascular biology.","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006958","count":15},{"id":"GO:0001867","count":14},{"id":"GO:0031639","count":11},{"id":"GO:0045766","count":10},{"id":"GO:0003050","count":9}]},{"hash":"1192706587330951998","title":"Cardiac morphogenesis and electrophysiology","description":"The cluster shows strong enrichment for heart development terms (outflow tract morphogenesis, left ventricular morphogenesis) and cardiac muscle electrical signaling (depolarization regulation, action potential regulation, hypertrophy in response to stress), suggesting proteins tied to heart structure formation and electrical function. Some sensory-related terms appear, but the dominant theme remains cardiac development and electrophysiology.","confidence":"High","size":15,"edges":6,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003151","count":15},{"id":"GO:0050976","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0050966","count":15},{"id":"GO:0060371","count":15}]},{"hash":"999337291948052439","title":"DNA damage response\u2013linked transcription and translation control","description":"The cluster is dominated by translation (GO:0006412) and ribosomal biogenesis terms, with related transcription elongation and regulation annotations (GO:0031564, GO:0032784, GO:0006354). It also includes DNA damage response signals mediated by p53 (GO:0006977, GO:1902167, GO:1902164) and gamma radiation response (GO:0071480), suggesting coordinated regulation of gene expression and protein synthesis in response to DNA damage. Together, these terms point to a functional theme of managing transcription and translation under DNA-damage stress.","confidence":"High","size":15,"edges":68,"triangles":185,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0042273","count":3},{"id":"GO:0006977","count":2},{"id":"GO:1902167","count":2},{"id":"GO:0031564","count":2}]},{"hash":"1885583452047419619","title":"Oxidative stress response and redox homeostasis","description":"The cluster is dominated by GO terms for redox balance and detoxification (cellular redox homeostasis, cellular oxidant detoxification, cellular response to oxidative stress), with additional links to protein quality control (protein folding in ER, deglutathionylation) and stress-influenced transcription regulation (DNA binding regulation). This points to a cohesive module focused on managing oxidative damage and maintaining redox homeostasis, including downstream effects on gene expression and protein folding.","confidence":"High","size":15,"edges":60,"triangles":116,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":13},{"id":"GO:0098869","count":11},{"id":"GO:1903026","count":9},{"id":"GO:0055114","count":9},{"id":"GO:0080058","count":9}]},{"hash":"310017399094760269","title":"Oxidative stress response and epithelial homeostasis","description":"The cluster centers on oxidative stress signaling (cellular response to hydrogen peroxide) and broader stress/chemical responses (xenobiotic stimulus, cAMP signaling) with additional hints at epithelial barrier and transport functions (corneocyte development, renal water transport). This suggests a cohesive theme of cellular stress response linked to epithelial integrity and fluid regulation, despite some terms being obsolete. ","confidence":"Medium","size":15,"edges":28,"triangles":27,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0070301","count":5},{"id":"GO:1903507","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0080111","count":4},{"id":"GO:0003335","count":4}]},{"hash":"118141999249693939","title":"PNS Myelination and Immune Signaling","description":"This cluster centers on peripheral nervous system myelination (GO:0022011) and includes multiple immune/inflammatory functions such as phagocytosis regulation, defense against Gram-positive bacteria, nitric oxide and reactive oxygen species production, IL-8 regulation, and inflammatory response modulation. The combination suggests proteins involved in Schwann cell\u2013mediated myelination that also coordinate neuroimmune signaling.","confidence":"High","size":15,"edges":5,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0022011","count":11},{"id":"GO:0050766","count":9},{"id":"GO:0050830","count":9},{"id":"GO:0045429","count":9},{"id":"GO:0044869","count":8}]},{"hash":"849342059576073857","title":"DNA Repair and Genome Maintenance","description":"The enrichment includes base-excision repair, DNA recombination, DNA catabolic process, and DNA demethylation, pointing to genome maintenance and nucleic acid remodeling as the core theme. While some terms like cellular response to xenobiotic stimulus and cAMP signaling are more general stress responses, the central cluster appears to group proteins involved in DNA repair and epigenetic/nucleic acid metabolism.","confidence":"High","size":15,"edges":58,"triangles":109,"max_degree":13,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042493","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0090502","count":6},{"id":"GO:0006284","count":6},{"id":"GO:0006310","count":6}]},{"hash":"790907938095548013","title":"CNS axon guidance and innate immune signaling","description":"The cluster centers on neural development features such as corticospinal axon guidance and corpus callosum development, yet also shows prominent innate immune signaling components (TLR signaling, macrophage activation) and GPCR/JAK-STAT/NF-kB pathway modulation. This suggests a cohesive theme around CNS development with immune signaling cross-talk and synaptic modulation.","confidence":"Medium","size":15,"edges":73,"triangles":174,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0021972","count":14},{"id":"GO:0022038","count":14},{"id":"GO:0007186","count":14},{"id":"GO:0007252","count":14},{"id":"GO:0046426","count":14}]},{"hash":"491176951309068449","title":"Steroid and bile acid metabolism with detoxification","description":"The cluster shows strong representation of bile acid biosynthesis and catabolism, progesterone and retinoic acid-related metabolism, glutathione biosynthesis, and xenobiotic detox processes (naphthalene catabolic process, redox-related terms). This points to a cohesive theme of steroid/bile acid metabolism and detoxification pathways, with auxiliary links to hormone signaling and tissue homeostasis, suggesting liver- or detox-related functions. ","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001894","count":15},{"id":"GO:0060135","count":15},{"id":"GO:0006699","count":15},{"id":"GO:1900053","count":15},{"id":"GO:0046427","count":15}]},{"hash":"765730530132208198","title":"Antibacterial defense and cell wall degradation","description":"This cluster is dominated by terms related to defense against bacteria (defense response to bacterium), cytolysis, and breakdown of bacterial cell wall components (peptidoglycan catabolic process, cell wall macromolecule catabolic process), suggesting a theme of host antibacterial activity and bacterial cell wall degradation. Some outlier terms (viral release, locomotory behavior, electron transport) are less clearly connected, but do not override the core antibacterial/degradative signature.","confidence":"Medium","size":15,"edges":92,"triangles":312,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":15},{"id":"GO:0019835","count":15},{"id":"GO:0019076","count":15},{"id":"GO:0009253","count":15},{"id":"GO:0007194","count":15}]},{"hash":"867527723202716713","title":"Dopaminergic signaling and neural development","description":"Most top terms cluster around nervous system signaling and development, particularly dopaminergic synaptic transmission, neuropeptide signaling, and enteric nervous system development, with related behaviors like grooming and pain perception. A few terms (saliva secretion, metanephric glomerulus development) are less aligned but do not override the core theme. Thus the label reflects the central role of dopaminergic/neuropeptide signaling in neural function and development.","confidence":"High","size":15,"edges":21,"triangles":35,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":15},{"id":"GO:0072224","count":15},{"id":"GO:0060160","count":15},{"id":"GO:0048484","count":15},{"id":"GO:2000458","count":15}]},{"hash":"28243768867370460","title":"Ubiquitin-regulated immune cell differentiation","description":"This cluster is dominated by GO terms tied to ubiquitin-mediated protein turnover (ubiquitin-dependent proteolysis and regulation of ubiquitination) and immune cell differentiation (germinal center formation, memory T cell differentiation, dendritic cell differentiation), suggesting a theme of ubiquitin-regulated pathways shaping immune cell development. Some terms like circadian rhythm or nervous system development are pleiotropic annotations, but the core signal points to ubiquitin-regulated immune differentiation.","confidence":"Medium","size":15,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0042752","count":10},{"id":"GO:0002467","count":9},{"id":"GO:0045214","count":8},{"id":"GO:0043380","count":8}]},{"hash":"1932459979116366422","title":"Neural and Muscle Development Signaling","description":"The top GO terms emphasize nervous system development and skeletal muscle tissue development, with supporting signals such as cell migration and various signaling pathways (insulin receptor signaling, GM-CSF response, B cell receptor signaling). This suggests a theme of developmental processes and signaling across neural and muscular contexts, with broader immune and ECM-related processes. The label is concise and representative of the cluster\u2019s core theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007399","count":9},{"id":"GO:0050853","count":9},{"id":"GO:0007519","count":9},{"id":"GO:0016477","count":7},{"id":"GO:0046329","count":6}]},{"hash":"2271717887639775864","title":"Transmembrane Transporters","description":"The cluster is dominated by GO terms for transport across membranes, including sodium, xenobiotic, sugar (arabinose, galactose, fucose), sialic acid, phosphate, and nitrate transmembrane transport, plus a vesicular transport term (neurotransmitter loading into synaptic vesicle). This cohesive theme suggests a group of membrane transporter proteins handling diverse substrates, hence a label focused on transmembrane transporters is appropriate and representative.","confidence":"High","size":15,"edges":89,"triangles":300,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":14},{"id":"GO:0006855","count":14},{"id":"GO:0015751","count":14},{"id":"GO:0015739","count":14},{"id":"GO:0035435","count":14}]},{"hash":"1474237030706464156","title":"T cell activation and immune signaling with stress responses","description":"The cluster is dominated by GO terms related to T cell activation and costimulation (GO:0031295, GO:0042110), suggesting an immune signaling theme. Additional terms point to cellular stress and metabolic contexts (proteolysis, hypoxia response, oxidative detoxification, regulation of insulin secretion), which often intersect with immune signaling in stress conditions. Some other terms (chlorophyll catabolic process, locomotory exploration, symbiont entry) appear less coherent with the main theme and may reflect annotation noise or cross-species annotations. Overall, the strongest signal is adaptive immune signaling with associated cellular stress responses.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031295","count":3},{"id":"GO:0010716","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0035641","count":3},{"id":"GO:0046718","count":3}]},{"hash":"2295060696029865552","title":"Multisubstrate Membrane Transport","description":"The GO terms cluster around diverse transmembrane transport activities\u2014sialic acid, nitrite, phosphate, sodium, galactose, xenobiotics, and related transporter roles\u2014plus a neuronal vesicle loading process, indicating a group of membrane transport proteins with broad substrate range.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":8},{"id":"GO:0015707","count":8},{"id":"GO:0035435","count":8},{"id":"GO:0035725","count":8},{"id":"GO:0015757","count":8}]},{"hash":"1958458218228378166","title":"Placental and mesodermal embryonic development","description":"The prominent GO terms include trophoblast giant cell differentiation, placental development, mesoderm formation, left-right patterning and cartilage morphogenesis, with additional endocrine development signals. A few terms on transcriptional regulation and splicing are present, but the strongest signal centers on placental/mesodermal embryogenesis, so the label captures the cluster\u2019s core function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0060972","count":14},{"id":"GO:0060536","count":14},{"id":"GO:0003323","count":14}]},{"hash":"1253578301408577845","title":"Fatty acid and bile acid metabolism","description":"The cluster is dominated by lipid metabolism terms: bile acid biosynthesis, taurine metabolism, long-chain/very long-chain fatty acid metabolism, unsaturated fatty-acid metabolic processes, and fatty-acyl-CoA biosynthesis, suggesting a lipid-centric functional theme. Some outlier terms (proteolysis, T cell costimulation, ECM disassembly) appear but do not override the lipid signal.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006508","count":5},{"id":"GO:0006699","count":4},{"id":"GO:0031295","count":4},{"id":"GO:0010716","count":4},{"id":"GO:0019530","count":4}]},{"hash":"2007088912834865049","title":"Embryonic patterning and organ morphogenesis","description":"The cluster is enriched for GO terms such as left/right pattern formation, endocrine system development, placental differentiation, cartilage morphogenesis, trophoblast giant cell differentiation, pancreatic beta cell development, and EMT in endocardial cushion formation, indicating a cohesive theme of embryonic development and tissue morphogenesis.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":9},{"id":"GO:0035270","count":9},{"id":"GO:0060806","count":9},{"id":"GO:0060536","count":9},{"id":"GO:0060707","count":9}]},{"hash":"1447463804063391842","title":"Cell adhesion and immune regulation","description":"The top GO terms cluster around cell-cell adhesion (heterophilic adhesion, actin-cytoskeleton regulation by adhesion, synapse assembly) and immune signaling (regulation of NK/T cell activity, macrophage activation, monocyte chemotaxis), suggesting proteins that mediate cell\u2013cell interfaces and modulate immune responses, with a possible link to host-symbiont entry.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":8},{"id":"GO:0090138","count":8},{"id":"GO:0086072","count":8},{"id":"GO:0043318","count":8},{"id":"GO:0051963","count":8}]},{"hash":"789868260468342239","title":"Neuropeptide GPCR Signaling and Feeding Regulation","description":"The top GO terms cluster around neuropeptide signaling and adenylate cyclase-activating GPCR pathways, with eating behavior and somatostatin secretion suggesting neuroendocrine control of feeding. Calcium import regulation and temperature homeostasis further support a neuroendocrine/signaling theme, while inflammatory regulation and apoptosis terms are present but less central. Overall, the dominant signal is neuropeptide GPCR signaling governing feeding-related hormonal activity.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":4},{"id":"GO:0007189","count":3},{"id":"GO:0042755","count":2},{"id":"GO:0001659","count":2},{"id":"GO:0002878","count":2}]},{"hash":"1273683538693619817","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms cluster around developmental processes across tissues (mesoderm development, left-right pattern formation, cartilage morphogenesis, hair follicle morphogenesis, epithelial-to-mesenchymal transition in heart development, pancreatic cell development, trophoblast differentiation, etc.), indicating a shared role in developmental differentiation and morphogenesis. There is also a signal for transcriptional and RNA processing control (negative regulation of RNA polymerase II binding and spliceosome-mediated splicing), suggesting coordinated gene expression regulation during development. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:1903026","count":4},{"id":"GO:0007498","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4}]},{"hash":"1284396068466943043","title":"Unknown","description":"The GO terms are diverse: transcription regulation, defense/inflammation, development and morphogenesis, and physiological processes like blood pressure regulation. With no clear dominant function and an edge-less cluster, there isn't a cohesive biological theme to label. Therefore, Unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0007596","count":5},{"id":"GO:0002523","count":5}]},{"hash":"1207219830554987949","title":"Neuronal signaling and behavior regulation","description":"Most of the top GO terms describe nervous system development, sensory perception, and neural signaling (locomotory and grooming behaviors, pain perception, neuropeptide signaling, and dopamine signaling regulation), indicating a cluster of proteins functionally linked to neural signaling and behavioral regulation. A few terms (saliva secretion, metanephric glomerulus development) appear peripheral or context-specific, but do not override the dominant neural theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":15},{"id":"GO:0046541","count":14},{"id":"GO:0072224","count":14},{"id":"GO:0060160","count":14},{"id":"GO:0048484","count":14}]},{"hash":"437827983049737069","title":"Embryonic development and neuronal differentiation","description":"Based on the top GO terms, there is a clear emphasis on early developmental processes (primitive streak formation, intestinal epithelial development) and neural development (peripheral nervous system neuron development, synaptic vesicle endocytosis). While other terms indicate broader regulatory roles (transcription, cell cycle, protein folding, hormone signaling), the dominant theme points to embryogenesis with neural differentiation. Confidence: Medium.","confidence":"","size":14,"edges":43,"triangles":70,"max_degree":10,"top_function":"protein folding","top_go_terms":[{"id":"GO:0060576","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0090009","count":5},{"id":"GO:0048935","count":5},{"id":"GO:0007339","count":4}]},{"hash":"427027961216210628","title":"Unknown","description":"The GO terms are highly diverse: mitotic cell cycle and cell division are present alongside Golgi organization, ribosomal export, immune development signals (beta selection), MAPK signaling (JNK/ERK cascades), and nervous system development. This lack of a cohesive, single-function theme makes it inappropriate to assign a specific, representative label to the cluster.","confidence":"","size":14,"edges":35,"triangles":25,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0007030","count":5},{"id":"GO:0042832","count":5},{"id":"GO:0000055","count":5}]},{"hash":"1054174855490473993","title":"Auditory system development and inner-ear function","description":"The top terms center on sensory perception of sound, auditory receptor cell stereocilium organization, and PNS myelin maintenance, with supporting signals from cell adhesion and ERK/PI3K pathways. While thymus and heart development appear, the strongest theme is hearing-related processes and peripheral nervous system maintenance, suggesting this cluster represents inner-ear/hair cell function and associated signaling. ","confidence":"Medium","size":14,"edges":36,"triangles":40,"max_degree":10,"top_function":"wound healing","top_go_terms":[{"id":"GO:0048538","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0007605","count":4},{"id":"GO:0032287","count":4}]},{"hash":"603819765642517036","title":"Amino Acid Metabolism and Heme Biosynthesis","description":"The cluster centers on amino acid turnover (aspartate, kynurenine, lysine) and related intermediates (oxaloacetate) with biosynthesis of cofactors such as biotin and heme/porphyrin. This combination suggests a cohesive metabolic module linking amino acid catabolism with porphyrin/heme biosynthesis.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":9},{"id":"GO:0006782","count":9},{"id":"GO:0009102","count":9},{"id":"GO:0006533","count":8},{"id":"GO:0019518","count":8}]},{"hash":"153355304146328013","title":"Stress-Driven Proteostasis and Cell Cycle Arrest","description":"The terms cluster around proteostasis and stress responses across compartments (ER folding, ubiquitin-proteasome\u2013mediated quality control in the nucleus, membrane targeting) and general stress responses (heat), with additional notes on translation maintenance (frameshifting, tRNA import) and mitochondrial remodeling (cristae formation). The presence of cell-cycle\u2013related terms (APC/C-dependent catabolic process, G1 to G0 transition) and cellular senescence suggests a concerted shift toward arrest and senescence under stress, linking proteostasis with cell-cycle regulation.","confidence":"Medium","size":14,"edges":16,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042407","count":1},{"id":"GO:0031145","count":1},{"id":"GO:0090398","count":1},{"id":"GO:0070314","count":1},{"id":"GO:0006452","count":1}]},{"hash":"1320481907739996811","title":"Unknown","description":"The top terms show Notch signaling, but the rest are a set of diverse and often obsolete metabolic/catabolic processes, with no clear, cohesive biological theme tying the cluster together. This makes it hard to assign a robust, representative function to the group.","confidence":"","size":14,"edges":16,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":3},{"id":"GO:0019878","count":2},{"id":"GO:0006533","count":2},{"id":"GO:0019518","count":2},{"id":"GO:0006107","count":2}]},{"hash":"1906289327698385189","title":"Developmental angiogenesis and PI3K/AKT signaling","description":"This cluster centers on angiogenesis and embryonic development, with GO terms for angiogenesis, CNS development, and embryonic cranial skeleton morphogenesis, plus positive regulation of PI3K/AKT signaling. The combination suggests a module of proteins coordinating vascular development and neural/cranial morphogenesis through PI3K/AKT and related signaling pathways, with some inflammatory signaling potentially as a secondary context.","confidence":"High","size":14,"edges":23,"triangles":12,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0090073","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0006954","count":2},{"id":"GO:0033138","count":2}]},{"hash":"2023412128094722923","title":"Circadian entrainment and magnetoreception","description":"This cluster is dominated by circadian-related terms (locomotor rhythm, entrainment of circadian clock by photoperiod) and magnetoreception (response to magnetism, magnetoreception), suggesting a shared role in circadian timing and environmental sensing. Metabolic terms are present but do not define the theme. ","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008203","count":1},{"id":"GO:0033615","count":1},{"id":"GO:0045475","count":1},{"id":"GO:2000323","count":1},{"id":"GO:0071000","count":1}]},{"hash":"139670655151290011","title":"Brain development and stress-regulated apoptosis","description":"This cluster combines neural development signals (cerebral cortex and corpus callosum development, axon regeneration) with stress- and survival-related pathways (ER stress\u2013induced apoptosis, JNK signaling, anoikis regulation). While some terms (DNA damage checkpoint, meiotic DSB formation) are less directly linked to neural development, the overarching theme appears to be brain development intertwined with cellular stress responses that influence survival and regeneration.","confidence":"Medium","size":14,"edges":40,"triangles":52,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":14},{"id":"GO:0070059","count":14},{"id":"GO:0046329","count":14},{"id":"GO:0072428","count":14},{"id":"GO:0021987","count":14}]},{"hash":"187266025968613752","title":"Unknown","description":"The top GO terms span insulin secretion regulation, symbiont entry into host cell, cell proliferation control, T cell costimulation, various catabolic processes (nicotine, formaldehyde, cellulose), proteolysis, ECM disassembly regulation, and an animal behavior term. This mix shows no single cohesive biological function or pathway tying the cluster together, suggesting either diverse, unrelated roles or annotation noise. ","confidence":"","size":14,"edges":55,"triangles":93,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050796","count":6},{"id":"GO:0046718","count":6},{"id":"GO:0060244","count":5},{"id":"GO:0031295","count":5},{"id":"GO:0019608","count":5}]},{"hash":"1659905520104279774","title":"Neural development and synaptic signaling","description":"The top GO terms point to neural-specific processes: cerebral cortex neuron migration and dopaminergic synaptic transmission regulation, alongside cadherin-mediated cell adhesion, suggesting roles in neuronal development and neuron-to-neuron communication. Additional terms about transcription regulation and DNA topology may reflect broader gene-expression control supporting these neural processes. Overall, the cluster appears to center on neural development and synaptic signaling, with some regulatory functions, hence the label.","confidence":"Medium","size":14,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006265","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0021795","count":2},{"id":"GO:2000049","count":1},{"id":"GO:1901585","count":1}]},{"hash":"1994716543944033550","title":"Cytokine signaling and monoamine metabolism","description":"The top GO terms center on immune signaling, with responses to GM-CSF and M-CSF stimuli, T cell receptor signaling, and interferon production, indicating a core cytokine/immune signaling cluster. Concurrently, serotonin and dopamine metabolic processes and cAMP regulation suggest cross-talk with monoamine signaling and second-messenger pathways, placing the cluster at the intersection of cytokine signaling and monoamine metabolism.","confidence":"High","size":14,"edges":45,"triangles":60,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":8},{"id":"GO:0042428","count":8},{"id":"GO:0036006","count":7},{"id":"GO:0042053","count":7},{"id":"GO:0055118","count":7}]},{"hash":"870128295429079844","title":"Collagen Matrix Formation and Skin Morphogenesis","description":"This cluster is dominated by collagen-related terms (collagen fibril organization, collagen biosynthetic process) and skin development/morphogenesis, suggesting a core role in extracellular matrix assembly and skin-tissue architecture. Additional signals for lymphangiogenesis and podocyte development extend to broader connective tissue morphogenesis, with a minor immune component from complement activation. Overall, collagen formation and skin/tissue morphogenesis best describe the cluster.","confidence":"High","size":14,"edges":14,"triangles":1,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":9},{"id":"GO:0045162","count":9},{"id":"GO:0006958","count":9},{"id":"GO:0043588","count":9},{"id":"GO:0032964","count":8}]},{"hash":"744029353979856977","title":"Chromatin organization and spermatogenesis","description":"The top GO terms point to nuclear chromatin regulation and chromosome dynamics (e.g., heterochromatin formation, chromosome condensation, nucleus organization, histone methylation regulation, transcription regulation by RNA Pol II) together with germ cell\u2013specific processes (sperm DNA condensation, spermatid development). This suggests a cohesive cluster centered on chromatin organization during germ cell development, with some peripheral signals related to growth or differentiation. ","confidence":"High","size":14,"edges":88,"triangles":329,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0042692","count":8},{"id":"GO:0051572","count":8},{"id":"GO:0035264","count":8},{"id":"GO:0031508","count":8}]},{"hash":"14113421365268411","title":"Ubiquitin-Dependent Antiviral Defense","description":"The top terms cluster around ubiquitin-mediated proteolysis and autophagy, with several items linking to antiviral responses (defense against virus, NF-kappaB signaling) and control of viral material transport. This suggests a coordinated ubiquitin/autophagy-based antiviral defense mechanism, making a concise label like this representative. ","confidence":"High","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0006914","count":8},{"id":"GO:0070534","count":8},{"id":"GO:0043123","count":8},{"id":"GO:0051607","count":8}]},{"hash":"865404297222185648","title":"Leukocyte Migration and Cytoskeletal Signaling","description":"The cluster's top GO terms center on cell migration and actin cytoskeleton dynamics, along with immune cell activation signals (IL-7 response, T cell proliferation, B cell differentiation) and membrane trafficking (caveolin-mediated endocytosis, adhesion-dependent spreading). Together these indicate a cohesive theme of leukocyte movement and signaling coupled to cytoskeletal remodeling.","confidence":"High","size":14,"edges":83,"triangles":286,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016477","count":13},{"id":"GO:2000251","count":13},{"id":"GO:0072584","count":12},{"id":"GO:0098761","count":12},{"id":"GO:0002333","count":12}]},{"hash":"785124711211668719","title":"Neuronal axonogenesis and microtubule organization","description":"The cluster is dominated by GO terms tied to neuron development and axon biology: establishment or maintenance of microtubule cytoskeleton polarity, peripheral nervous system neuron axonogenesis, retrograde axonal transport, and neurofilament bundle assembly. Together these indicate a module focused on axon formation and cytoskeletal architecture in neurons, with a couple of less central terms (e.g., fast-twitch muscle contraction) likely representing broader cytoskeletal or housekeeping overlaps. ","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0031443","count":14},{"id":"GO:0043000","count":14},{"id":"GO:0090343","count":14},{"id":"GO:0035105","count":14},{"id":"GO:1904714","count":14}]},{"hash":"1332068922428765186","title":"ER stress and chaperone-mediated protein folding","description":"Top GO terms cluster around heat/unfolded protein response, chaperone-assisted refolding, ER-targeted translation, and membrane translocation, indicating a coordinated ER stress\u2013driven protein quality-control program. Redox homeostasis supports stress adaptation; a peripheral DNA replication term is less central. ","confidence":"High","size":14,"edges":58,"triangles":117,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":9},{"id":"GO:0031204","count":8},{"id":"GO:0009408","count":8},{"id":"GO:0090084","count":8},{"id":"GO:0006260","count":8}]},{"hash":"1899780587508110131","title":"Metanephric tubule morphogenesis","description":"Proteins in this cluster are strongly linked to metanephric tubule morphogenesis, including distal and proximal tubule development and related nephron segments, pointing to a kidney development theme. While there are immune-related terms present (Fc-gamma receptor signaling, basophil activation, leukocyte tethering/rolling, phagocytosis recognition), these appear less central to the main kidney morphogenesis signal. Overall, the dominant function is kidney tubule development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072287","count":13},{"id":"GO:0038094","count":13},{"id":"GO:0071226","count":13},{"id":"GO:0036303","count":13},{"id":"GO:0090403","count":13}]},{"hash":"706984771202173580","title":"Autophagy and organelle turnover","description":"Proteins in this cluster are enriched for autophagy-related GO terms such as autophagosome assembly, mitophagy, phagophore targeting, and Cvt pathways, spanning macroautophagy and selective organelle degradation (including nucleus and mitochondria), suggesting a cohesive autophagy-focused module.","confidence":"High","size":14,"edges":39,"triangles":54,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0044805","count":4},{"id":"GO:0000045","count":4},{"id":"GO:0045850","count":4},{"id":"GO:0035096","count":4},{"id":"GO:0032258","count":4}]},{"hash":"171217829434121586","title":"Neuronal synaptic signaling and vascular regulation","description":"This cluster centers on cell-surface signaling linked to neural activity, emphasized by glutamatergic synaptic transmission and AMPA receptor activity, while also including vascular-related functions (platelet activation and vasoconstriction). Immune and embryonic processes appear as additional signals, but the strongest coherent theme is membrane-initiated signaling affecting neuronal communication and vascular responses.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034394","count":3},{"id":"GO:0030168","count":3},{"id":"GO:0007566","count":3},{"id":"GO:0010226","count":3},{"id":"GO:2000311","count":3}]},{"hash":"691022603800020083","title":"Neural signaling and sensory perception","description":"This cluster features GO terms centered on neuronal signaling and sensory processing: GPCR-PLC mediated glutamate receptor signaling, sodium and calcium transport linked to neuronal excitability, detection of light stimulus, cellular response to electrical stimulus, and memory. Energy metabolism (electron transport chain) supports neural activity. Some terms (negative regulation of oocyte maturation, fungicide response) are not aligned with neurons, suggesting annotation noise, but the dominant theme is neural signaling and light perception, supporting the label.","confidence":"Medium","size":14,"edges":19,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":14},{"id":"GO:0035725","count":14},{"id":"GO:0030818","count":14},{"id":"GO:0060992","count":14},{"id":"GO:0090280","count":14}]},{"hash":"1722914540266268030","title":"Unknown","description":"The top GO terms are highly diverse, covering taste perception (umami, conditioned taste aversion), kidney/urinary tract development (metanephric tubule and duct development), cartilage condensation, lymphatic/immune pathways, and even locomotor/behavior terms. There isn\u2019t a clear shared function or pathway linking these terms, so a single cohesive label isn\u2019t supported.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050917","count":3},{"id":"GO:0072287","count":2},{"id":"GO:0036303","count":2},{"id":"GO:0072218","count":2},{"id":"GO:0072237","count":2}]},{"hash":"1355456540655250335","title":"Neural development and axon regeneration","description":"This cluster is dominated by GO terms linked to brain development (cerebral cortex development, corpus callosum development) and neuronal connectivity processes (regulation of axon regeneration). Additional terms touch on neuronal survival signaling (ER-stress\u2013related apoptotic pathways, JNK cascade regulation) and cell proliferation, which can accompany neural progenitor biology. A few terms (meiotic DSB formation, galactose-induced transcription) appear less related and may reflect annotation noise, but the neural theme is the strongest signal. ","confidence":"Medium","size":14,"edges":58,"triangles":116,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":14},{"id":"GO:0070059","count":14},{"id":"GO:0046329","count":14},{"id":"GO:0072428","count":14},{"id":"GO:0021987","count":14}]},{"hash":"1157808818726322679","title":"Ribosome Biogenesis and Translation Machinery","description":"This cluster is dominated by GO terms tied to ribosome assembly and protein synthesis (ribosome biogenesis; maturation of LSU/5.8S rRNA; translation; translational initiation), supported by GO:0042254, GO:0000463, GO:0000466, GO:0006412, and GO:0006413. Some peripheral terms (abiotic stress response, megakaryocyte differentiation, fatty acid biosynthesis regulation, glycolytic regulation, miRNA-mediated silencing) are less central to ribosome function, but the core signal points to ribosome biogenesis and translation as the common theme.","confidence":"High","size":14,"edges":62,"triangles":125,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0000466","count":1},{"id":"GO:0071215","count":1},{"id":"GO:0045652","count":1},{"id":"GO:0042304","count":1}]},{"hash":"1716164086821636169","title":"Gram-negative cell envelope biosynthesis and stress response","description":"This cluster is dominated by GO terms for cell envelope construction: peptidoglycan, lipid A, and lipopolysaccharide biosynthesis, with UDP-N-acetylglucosamine as a shared precursor, plus terms for antibiotic/xenobiotic/toxic-substance responses and regulation of cell shape, all pointing to envelope biosynthesis and bacterial stress adaptation.","confidence":"High","size":14,"edges":58,"triangles":109,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006048","count":4},{"id":"GO:0009437","count":4},{"id":"GO:0005978","count":3},{"id":"GO:0009245","count":3},{"id":"GO:0009103","count":3}]},{"hash":"51483787836553060","title":"Neural development signaling and myelination","description":"The terms are dominated by nervous system\u2013related processes: nervous system development, neurogenesis, peripheral nervous system development, myelination, and signaling pathways like ROBO (Roundabout), SHH (Smoothened), and BMP signaling. This points to a cluster of proteins involved in neural patterning, axon guidance, and glial differentiation, with supportive roles in myelination and early neural development.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0007422","count":4}]},{"hash":"457072094701334730","title":"Inflammation and TRAIL-induced Apoptosis","description":"The cluster is dominated by immune/inflammatory signals and programmed cell death, with terms like inflammatory response, activation-induced T cell death, TRAIL production and TRAIL-activated apoptotic signaling, and PKC signaling, plus related processes such as fever regulation and endothelial barrier establishment. An outlier term for plant flower morphogenesis is likely annotation noise, but the core theme revolves around TRAIL-mediated apoptosis within inflammatory contexts.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006924","count":14},{"id":"GO:0071812","count":14},{"id":"GO:0048439","count":14},{"id":"GO:0045556","count":14},{"id":"GO:0006954","count":14}]},{"hash":"879262650008287865","title":"Unknown","description":"The terms point to diverse processes, including insulin/glucose signaling and various developmental and chromatin-related activities, with no single dominant function uniting the proteins. Therefore a coherent, specific label is not supported.","confidence":"","size":14,"edges":34,"triangles":6,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008286","count":5},{"id":"GO:0070562","count":4},{"id":"GO:0061038","count":4},{"id":"GO:0090043","count":4},{"id":"GO:1903699","count":4}]},{"hash":"866587989468940486","title":"Cytoskeleton Remodeling and EMT Regulation","description":"Based on the top GO terms, the cluster centers on cytoskeletal dynamics (actin cytoskeleton reorganization, actomyosin structure organization), regulation of cell\u2013cell adhesion, and processes linked to epithelial-to-mesenchymal transition, together with linked proliferation control. These repeatedly co-occur, suggesting a coherent theme of cytoskeleton-driven adhesion remodeling and EMT signaling.","confidence":"Medium","size":14,"edges":43,"triangles":50,"max_degree":10,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0008285","count":5},{"id":"GO:0008033","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0022408","count":3},{"id":"GO:0009826","count":3}]},{"hash":"46174989317737837","title":"Neural development and apoptosis regulation","description":"This cluster centers on brain development terms (cerebral cortex development, corpus callosum development, regulation of axon regeneration) and on apoptosis/stress signaling (negative regulation of anoikis, ER-stress\u2013induced apoptotic signaling, regulation of JNK cascade), suggesting proteins that coordinate neural development with cell survival and stress responses. Some DNA damage checkpoint/meiotic terms appear less directly connected but may reflect broader regulatory networks.","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":13},{"id":"GO:0070059","count":13},{"id":"GO:0046329","count":13},{"id":"GO:0072428","count":13},{"id":"GO:0021987","count":13}]},{"hash":"1130994744832225496","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006203","count":3},{"id":"GO:0050992","count":3},{"id":"GO:0016077","count":3},{"id":"GO:0071544","count":3},{"id":"GO:0015967","count":3}]},{"hash":"1528772602314416140","title":"ER folding and ERAD quality control","description":"The top GO terms cluster around ER proteostasis: protein folding in the ER, post-translational targeting to membranes, ER-associated degradation via ubiquitin-proteasome, and misfolded protein transport, with heat response reflecting proteostasis stress. These together strongly indicate an ER folding/quality-control themed cluster.","confidence":"High","size":14,"edges":86,"triangles":311,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006452","count":14},{"id":"GO:0031204","count":14},{"id":"GO:0009408","count":14},{"id":"GO:0035719","count":14},{"id":"GO:0034975","count":14}]},{"hash":"1979163496757256766","title":"Neuronal development and synaptic signaling","description":"The top GO terms center on axonogenesis, chemical synaptic transmission, and regulation of synaptic plasticity and ephrin signaling, all pointing to neural development and synaptic function. Supporting terms include angiogenesis and organismal growth, suggesting broader developmental context, while microtubule nucleation and spindle-related terms hint at cytoskeletal dynamics important for neurite outgrowth. Overall, this cluster seems to group proteins involved in neural development and synaptic signaling.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0007409","count":2},{"id":"GO:1903087","count":2},{"id":"GO:0007020","count":2},{"id":"GO:0035264","count":2}]},{"hash":"1646002892995635791","title":"Regulators of Cell Growth and Signaling","description":"The cluster shows a mix of terms tied to regulation of cell growth and the cell cycle (e.g., regulation of the cell cycle, exit from mitosis, tyrosine dephosphorylation), signaling pathway modulation (JAK-STAT, JNK), and broader regulatory processes like mRNA capping and development. While diverse, these terms point to a common theme of proteins that coordinate growth, division, and signaling during development, rather than a single, narrow pathway.","confidence":"Medium","size":14,"edges":54,"triangles":85,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035335","count":11},{"id":"GO:0061388","count":10},{"id":"GO:0001701","count":10},{"id":"GO:0031536","count":10},{"id":"GO:0006370","count":10}]},{"hash":"741749872532214201","title":"Ubiquitin-Proteasome System Proteolysis","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes, protein polyubiquitination, and SCF-dependent proteasomal degradation, indicating a core theme of ubiquitin-proteasome\u2013mediated protein turnover. Additional terms like cadmium response, circadian rhythm regulation, and neural tube-related processes suggest linked regulatory and stress-response roles associated with ubiquitination pathways.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0000209","count":11},{"id":"GO:0071276","count":9},{"id":"GO:0031146","count":9},{"id":"GO:0006516","count":8}]},{"hash":"2292497683854831447","title":"Post-transcriptional mRNA processing and translation initiation","description":"The proteins are enriched for splicing regulation, mRNA export, polyadenylation regulation, miRNA-mediated silencing, and initiation complex assembly (eIF4F), indicating a cohesive role in post-transcriptional control of mRNA fate and translation initiation.","confidence":"High","size":14,"edges":58,"triangles":132,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":6},{"id":"GO:0000381","count":5},{"id":"GO:0048026","count":5},{"id":"GO:1900363","count":5},{"id":"GO:0031047","count":5}]},{"hash":"1599822432482502716","title":"Cardiac electrophysiology and ion transport","description":"The top GO terms cluster around cardiac electrical activity\u2014membrane repolarization, resting potential regulation, cardiac muscle action potentials, and heart-rate control\u2014along with ion transport (potassium and magnesium). This points to a cohesive theme of cardiac electrophysiology and ionic homeostasis; the non-cardiac terms appear as ancillary processes in broader excitable-cell signaling but do not override the main pattern.","confidence":"High","size":14,"edges":32,"triangles":48,"max_degree":9,"top_function":"nervous system process","top_go_terms":[{"id":"GO:0098914","count":9},{"id":"GO:0060075","count":9},{"id":"GO:0086002","count":7},{"id":"GO:0086091","count":7},{"id":"GO:1990573","count":7}]},{"hash":"34580393604906567","title":"Centrosome and spindle dynamics in mitosis","description":"The top GO terms cluster around mitosis and microtubule control: mitotic cytokinesis, negative regulation of microtubule depolymerization, and localization to pericentriolar material all point to spindle assembly and centrosome function. The positive regulation of GTPase activity can modulate cytoskeletal dynamics, reinforcing this theme. Some terms (splicing, root meristem growth, telomerase assembly) are broader or context-specific but may reflect broader roles in nuclear/cell division processes. Overall, the proteins appear to coordinate centrosome-associated spindle dynamics during cell division.","confidence":"Medium","size":14,"edges":12,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0007026","count":2},{"id":"GO:0000281","count":2},{"id":"GO:0043547","count":2},{"id":"GO:1905793","count":1}]},{"hash":"944751894779297939","title":"Molybdenum cofactor biosynthesis","description":"The cluster is enriched for GO terms tied to molybdenum cofactor biosynthesis and related processes (molybdenum incorporation into Mo-molybdopterin, MoCo biosynthetic steps), suggesting a core function in MoCo production. The presence of additional terms like receptor clustering and heart development may reflect secondary annotations or multifunctional proteins within the group, but the MoCo biosynthesis theme best explains the overall signal.","confidence":"Medium","size":14,"edges":30,"triangles":28,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0018315","count":4},{"id":"GO:0097112","count":4},{"id":"GO:0072579","count":4},{"id":"GO:0032324","count":4},{"id":"GO:0006777","count":4}]},{"hash":"1631036625372909625","title":"Mitotic Chromosome Assembly and Cell Cycle Control","description":"This cluster is dominated by GO terms associated with mitosis and chromosome dynamics, including mitotic cell cycle, APC/C-dependent catabolic processes, and CENP-A chromatin assembly, which together point to regulation of chromosome segregation and cell division. Additional terms about histone methylation and protein oligomerization support a chromatin-structure\u2013related regulatory theme, with a minor inclusion of cadmium response that may reflect stress-related cell-cycle modulation. Overall, the strongest signal is mitosis and chromatin assembly, justifying this label.","confidence":"High","size":14,"edges":30,"triangles":13,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":11},{"id":"GO:0030433","count":11},{"id":"GO:0031145","count":10},{"id":"GO:0061641","count":10},{"id":"GO:2001162","count":10}]},{"hash":"1931900149454814319","title":"Cardiac signaling and cytoskeletal remodeling","description":"The enriched GO terms point to heart development and cardiac hypertrophy (regulation of calcineurin-NFAT signaling), together with GPCR signaling regulation, GTPase activity, and actin cytoskeleton organization, indicating a cluster of proteins involved in cardiac signal transduction and structural remodeling. The dsRNA response term is less heart-specific but does not override the central cardiac signaling theme.","confidence":"High","size":14,"edges":5,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008277","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0071360","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0007507","count":2}]},{"hash":"556087318281962396","title":"Axon Guidance and Planar Cell Polarity in Development","description":"The top GO terms point strongly to neuronal axon guidance (serotonergic and dopaminergic neuron guidance) and planar cell polarity signaling (even though one PCP term is obsolete), with supporting terms like cell-matrix adhesion and synapse assembly that fit into a broader theme of tissue morphogenesis and neural circuit formation. While there are unrelated development terms (kidney and bone), the recurring theme centers on guiding neural processes and PCP-driven organization. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":4},{"id":"GO:0007160","count":3},{"id":"GO:2000270","count":3},{"id":"GO:0071504","count":3},{"id":"GO:0051965","count":3}]},{"hash":"884085229285837484","title":"Melanosome Transport and Autophagy","description":"Reason: The strongest signals are endosome-to-melanosome transport, lipophagy, and regulation of autophagosome assembly, complemented by general endosomal trafficking and GPCR signaling, all within a skin-related developmental and repair context (hair follicle and wound healing). This suggests a cohesive theme of pigment cell trafficking and autophagy in the skin.","confidence":"High","size":14,"edges":81,"triangles":266,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902692","count":14},{"id":"GO:0044319","count":14},{"id":"GO:0035646","count":14},{"id":"GO:1902902","count":14},{"id":"GO:0007186","count":14}]},{"hash":"2262970191680036544","title":"Diverse metabolite biosynthesis","description":"This cluster includes GO terms for phylloquinone, poly-hydroxybutyrate, melanin, glucocorticoid, tetrahydrobiopterin, sphingolipid, fatty acid elongation, and tropane alkaloid biosynthetic processes, among others. The shared theme is biosynthesis of a wide range of metabolites rather than a single pathway, suggesting a general metabolic/biosynthetic function across diverse compounds.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042376","count":14},{"id":"GO:0042619","count":14},{"id":"GO:0042438","count":14},{"id":"GO:0055114","count":14},{"id":"GO:0006704","count":14}]},{"hash":"1101010535750678862","title":"Angiogenesis and vascular morphogenesis","description":"The top GO terms are dominated by endothelial/vascular development signals (VEGF receptor signaling, endothelial cell chemotaxis, coronary artery morphogenesis, placental branching morphogenesis) and matrix remodeling (proteolysis), which together point to angiogenesis and vascular morphogenesis as the core function of this protein cluster. While some terms touch broader developmental processes (neural crest migration, Purkinje layer development), the vascular theme is most representative of the cluster\u2019s common function.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":8},{"id":"GO:0048010","count":8},{"id":"GO:1901166","count":7},{"id":"GO:0035767","count":7},{"id":"GO:0021680","count":7}]},{"hash":"1480288689753521470","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":69,"triangles":179,"max_degree":13,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0016311","count":4},{"id":"GO:0097171","count":4},{"id":"GO:0006281","count":3},{"id":"GO:0009103","count":3},{"id":"GO:1990966","count":3}]},{"hash":"849694975727689578","title":"Endocrine Hormone Signaling Regulation","description":"Based on GO terms, the cluster centers on hormone signaling regulation, notably insulin receptor signaling, prolactin/cortisol-related regulation, and pancreatic beta cell proliferation, indicating endocrine signaling control. Some terms touch neural aspects (axon regeneration, vestibular morphogenesis), but the dominant theme across most proteins points to hormonal signaling and its regulatory processes.","confidence":"Medium","size":14,"edges":87,"triangles":320,"max_degree":13,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:1902212","count":14},{"id":"GO:2000646","count":14},{"id":"GO:0048679","count":14},{"id":"GO:2001275","count":14},{"id":"GO:0070373","count":14}]},{"hash":"130485684527272265","title":"Lipid and Xenobiotic Metabolism","description":"The cluster centers on catabolic processes for various organic substrates (lipids like triglycerides; endocannabinoid-related lipid signaling; other small molecules) and includes detoxification and response to toxic substances, suggesting a common theme of metabolizing and detoxifying lipid- and xenobiotic-derived compounds rather than a single precise pathway.","confidence":"Medium","size":14,"edges":26,"triangles":16,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":8},{"id":"GO:0055114","count":7},{"id":"GO:2000124","count":5},{"id":"GO:0006212","count":5},{"id":"GO:0042619","count":5}]},{"hash":"192290952526035164","title":"Neuronal cytoskeleton remodeling and axon growth","description":"Strong indications come from brain development, regulation of axon extension, cytoskeleton organization, and actin filament bundle assembly, pointing to neural cytoskeletal dynamics during neurite outgrowth. The various catabolic processes appear incidental to this central theme.","confidence":"Medium","size":14,"edges":77,"triangles":232,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0019262","count":4},{"id":"GO:0006146","count":4},{"id":"GO:0007010","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0030516","count":3}]},{"hash":"108435899573975827","title":"Axon Guidance and Paranodal Organization","description":"This cluster's GO terms cluster around neural development and wiring: multiple entries describe axon guidance (semaphorin-plexin signaling), axonogenesis, and innervation, while terms about paranodal/juxtaparanodal protein localization and paranodal junction assembly point to the structural organization of myelinated nerves. The trigeminal nerve and neural crest migration terms reinforce a developmental neural context. Retina layer formation is tangentially related as a neural tissue development process but less central. Overall, the dominant theme is formation and organization of neural connections, i.e., axon pathfinding and nodal region organization.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0031295","count":6},{"id":"GO:0010842","count":5},{"id":"GO:1900242","count":5},{"id":"GO:0036486","count":5},{"id":"GO:1902287","count":5}]},{"hash":"2094117113424584979","title":"Ventricular Cardiac Electrophysiology and Development","description":"The cluster is centered on ventricular heart muscle function, including regulation of membrane repolarization/depolarization and the cardiac action potential, along with heart development features like outflow tract morphogenesis and foramen ovale closure, and overall heart rate regulation by conduction. These GO terms together point to a cohesive module of ventricular electrophysiology and morphogenesis; a couple of peripheral terms (progesterone response, epididymis development) are less central but do not override the primary cardiac theme.","confidence":"High","size":14,"edges":56,"triangles":165,"max_degree":10,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0060307","count":10},{"id":"GO:0060373","count":10},{"id":"GO:0086091","count":10},{"id":"GO:0032570","count":10},{"id":"GO:0002931","count":10}]},{"hash":"2026036936672797542","title":"Dopaminergic Signaling and Nervous System Development","description":"This cluster is dominated by GO terms related to nervous system development and dopaminergic signaling, including dopaminergic synaptic transmission, neuropeptide signaling, enteric nervous system development, and behaviors or sensory processes like grooming and pain perception. While a few outlier terms (saliva secretion, metanephric glomerulus development, DN2 thymocyte differentiation) appear, the core theme centers on dopamine-related neural signaling and neurodevelopment, suggesting a cohesive label around dopaminergic nervous system functions.","confidence":"Medium","size":14,"edges":15,"triangles":2,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":14},{"id":"GO:0072224","count":14},{"id":"GO:0060160","count":14},{"id":"GO:0048484","count":14},{"id":"GO:2000458","count":14}]},{"hash":"402332132043916445","title":"Embryonic organogenesis and transcriptional regulation","description":"This cluster shows strong enrichment for developmental morphogenesis across multiple organs (ureteric bud morphogenesis, metanephric nephron tubule formation, otic placode formation, lacrimal gland development, face morphogenesis, habenula development) as well as transcriptional regulation (DNA-templated transcription, negative regulation of transcription by RNA polymerase II) and related signaling. The concordance of organogenesis-related GO terms with transcriptional control terms suggests a cohesive role in coordinating developmental programs with gene expression regulation.","confidence":"High","size":14,"edges":78,"triangles":286,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090190","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0043049","count":7},{"id":"GO:0035914","count":7},{"id":"GO:0072289","count":7}]},{"hash":"1010485525152878816","title":"Calcium-Triggered Secretion and Vesicle Trafficking","description":"Top terms span calcium-dependent exocytosis, neurotransmitter and protein secretion, vesicle trafficking and endosomal sorting, plus related dendrite and pigment granule dynamics. Together they define a cluster of proteins coordinating calcium-triggered secretion and secretory vesicle trafficking.","confidence":"High","size":14,"edges":13,"triangles":6,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0061669","count":4},{"id":"GO:0070257","count":4},{"id":"GO:0071985","count":4},{"id":"GO:0045956","count":4},{"id":"GO:0070073","count":4}]},{"hash":"1392086615587736491","title":"Neurodevelopment and Organ Morphogenesis","description":"The cluster is enriched for nervous system development, neurogenesis, transmission of nerve impulse, and synapse organization, indicating a strong neural development theme. At the same time, terms for metanephric tubule morphogenesis and lymph vessel morphogenesis suggest broader developmental roles across tissues. Overall, the proteins likely participate in developmental signaling guiding tissue morphogenesis, with a primary emphasis on neural development.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0036303","count":3},{"id":"GO:0072237","count":3},{"id":"GO:0072287","count":3},{"id":"GO:0019226","count":2}]},{"hash":"1234388322803742050","title":"Plant cell wall remodeling and plasmodesmata organization","description":"The top GO terms cluster around plant-specific cell wall modification, regulation of cellulose biosynthesis, and plasmodesmatal organization, with related processes like mucilage biosynthesis and root hair development, pointing to coordinated cell wall dynamics and intercellular connectivity in plants. Some non-plant terms appear as noise, but the dominant signal is plant cell wall remodeling. ","confidence":"High","size":14,"edges":47,"triangles":79,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":7},{"id":"GO:0009663","count":7},{"id":"GO:2001009","count":7},{"id":"GO:0075015","count":5},{"id":"GO:0018258","count":4}]},{"hash":"166961061372189522","title":"TLR signaling and macrophage-driven inflammation","description":"The top terms show a clear focus on innate immune sensing and response: Toll-like receptor signaling (TLR7/TLR8 and Toll signaling), macrophage activation, inflammatory response, and regulation of cytokine production (including interleukin-18). A fungal response term is also present, reinforcing a pattern of pathogen recognition and cytokine-mediated inflammation. Although a couple plant-related GO terms appear, the dominant theme is TLR-mediated innate immunity and macrophage-driven inflammation.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0009934","count":4},{"id":"GO:0032741","count":4},{"id":"GO:0006954","count":4},{"id":"GO:1900155","count":4},{"id":"GO:0034158","count":4}]},{"hash":"1401933349875735800","title":"Inhibition of vesicle trafficking and Golgi localization","description":"This cluster is enriched for terms related to vesicle transport and Golgi targeting, including negative regulation of SNARE complex assembly and endocytic recycling, as well as negative regulation of Rho/GTPase signaling that modulates cytoskeletal dynamics. The presence of Golgi localization establishment and regulation of cell movement-related processes (vascular permeability, sprouting angiogenesis, extravasation) suggests the proteins collectively influence trafficking and Golgi-related functions that affect cell migration and permeability rather than a single enzyme or receptor activity. Therefore, a label centered on vesicle trafficking and Golgi localization best captures the shared theme across the cluster.","confidence":"Medium","size":14,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035024","count":2},{"id":"GO:0035544","count":2},{"id":"GO:1904425","count":1},{"id":"GO:0051683","count":1},{"id":"GO:0030183","count":1}]},{"hash":"16695559433263536","title":"Neural development and synapse formation","description":"This cluster is dominated by nervous system functions, with terms for CNS development, neurogenesis, transmission of nerve impulse, and synapse assembly, indicating a cohesive neural development/synaptic function core; a few terms (ion transport, glomerular filtration, gland boundary specification) are less representative but do not override the main theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0042517","count":5},{"id":"GO:0003094","count":4},{"id":"GO:0019226","count":4},{"id":"GO:0007432","count":4}]},{"hash":"1862493301280230816","title":"Placental and vascular development signaling","description":"This cluster includes placental epithelial morphogenesis, endothelial proliferation, fibrinolysis, and hypoxia response, plus AKT activation and overall multicellular development, suggesting a core theme of placental/vascular morphogenesis and developmental signaling. Some terms (keratinocyte differentiation, visual perception, ovarian follicle development) appear as peripheral tissue-specific roles but do not override the main developmental signal.","confidence":"Medium","size":14,"edges":53,"triangles":73,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":3},{"id":"GO:0030216","count":3},{"id":"GO:0060672","count":3},{"id":"GO:0001938","count":3},{"id":"GO:0001666","count":3}]},{"hash":"1879036327489179491","title":"Dopaminergic Neuron Signaling and Development","description":"The cluster is dominated by neural-related GO terms, including dopaminergic synaptic transmission, neuropeptide signaling, and regulation of dopamine receptor signaling, plus nervous system development and related behaviors (grooming, enteric NS development). While a couple terms (saliva secretion, metanephric development) are less directly neural, the overall signal points to dopamine-associated neural signaling and development as the core theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":12},{"id":"GO:0072224","count":12},{"id":"GO:0060160","count":12},{"id":"GO:0048484","count":12},{"id":"GO:2000458","count":12}]},{"hash":"762154239267923699","title":"Notch and ubiquitination signaling regulators","description":"This cluster is enriched for protein ubiquitination and Notch signaling terms, with supporting hints from phosphorylation, nuclear export, and cell polarity. The presence of both Notch pathway and negative regulation of Notch pathway points to regulators of Notch signaling, potentially controlled by ubiquitin-mediated modification and trafficking.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0007118","count":1},{"id":"GO:0031031","count":1},{"id":"GO:2000100","count":1}]},{"hash":"1975107624237131737","title":"Nociception and heat/pain sensing","description":"The top GO terms are dominated by pain and thermal/mechanical sensory processes (response to pain, detection of mechanical stimulus involved in sensory perception of pain, response to heat), pointing to a nociception-related theme. Other terms in the list (e.g., fat cell differentiation, pinocytosis regulation, chloroplast thylakoid protein import) appear unrelated and likely constitute noise or mixed annotations. The label captures the core functional signal despite the presence of heterogeneous terms.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":3},{"id":"GO:0045444","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0050966","count":2},{"id":"GO:0048549","count":2}]},{"hash":"1418517952443520371","title":"Ion Transport and Membrane Homeostasis with Mineralization","description":"Top GO terms indicate predominately ion transport (sodium and copper), sodium homeostasis and export, ER calcium ion concentration regulation, and phospholipid translocation, pointing to membrane transport and ionic balance as the core theme. The presence of otolith mineralization and L-serine biosynthesis suggests ancillary roles in biomineralization and metabolism. Taken together, the cluster centers on membrane-associated ion transport and homeostasis, with a linked mineralization process.","confidence":"Medium","size":13,"edges":70,"triangles":213,"max_degree":12,"top_function":"establishment or maintenance of cell polarity","top_go_terms":[{"id":"GO:0045332","count":9},{"id":"GO:0045579","count":8},{"id":"GO:0002028","count":8},{"id":"GO:0045299","count":8},{"id":"GO:0006564","count":8}]},{"hash":"1632460049371058541","title":"Neural signaling and endothelial barrier regulation","description":"The GO terms are dominated by neural-related processes (myelination, regulation of long-term neuronal synaptic plasticity, sensory perception of sound) and barrier/membrane organization (endothelial barrier establishment, tight junction assembly, membrane raft polarization). This suggests a cluster of proteins coordinating neural signaling with barrier integrity, rather than a single immune or metabolic function. Some outlier terms (B cell differentiation, extrinsic apoptotic signaling) are present but less representative.","confidence":"Medium","size":13,"edges":76,"triangles":265,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":5},{"id":"GO:0048169","count":5},{"id":"GO:0002337","count":4},{"id":"GO:0035208","count":4},{"id":"GO:0001766","count":4}]},{"hash":"1591042124228042868","title":"Golgi- and synaptic vesicle trafficking","description":"This cluster is dominated by GO terms for vesicle transport through the Golgi (ER\u2192Golgi, intra-Golgi, Golgi to vacuole, Golgi ribbon formation) and vesicle docking/fusion (SNARE complex assembly, synaptic vesicle docking), with related roles in protein localization to the cell surface and receptor localization to synapse. Together these indicate a cohesive function in Golgi-mediated vesicle trafficking and synaptic vesicle machinery.","confidence":"High","size":13,"edges":13,"triangles":0,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048280","count":10},{"id":"GO:0090161","count":9},{"id":"GO:0006891","count":9},{"id":"GO:0006896","count":9},{"id":"GO:0006888","count":9}]},{"hash":"587145313800363463","title":"Phospholipid Biosynthesis","description":"The GO terms show multiple lipid biosynthetic processes (phosphatidylglycerol, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol) plus related lipid-derived pathways like platelet activating factor biosynthesis and response to phosphatidylethanolamine. Minor terms include biosynthesis of quinones and chlorophyll, suggesting a broader lipid metabolism program. Overall, the cluster appears to group enzymes/proteins involved in membrane lipid synthesis and related lipid pathways.","confidence":"High","size":13,"edges":73,"triangles":237,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006655","count":6},{"id":"GO:0010512","count":6},{"id":"GO:0006646","count":6},{"id":"GO:0006659","count":6},{"id":"GO:0006663","count":6}]},{"hash":"267223538068827902","title":"Adaptive immune signaling and phagocytosis","description":"The cluster is dominated by GO terms tied to adaptive immunity and immune signaling: T cell costimulation, B cell receptor signaling, adaptive immune response, cytokine production, and complement activation, with a consistent signal for phagocytosis. A few terms like spermatid development, proteolysis, and cardiac depolarization regulation appear less central, likely representing multifunctional proteins or annotation noise, but the core pattern points to adaptive immune processes.","confidence":"High","size":13,"edges":54,"triangles":97,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031295","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0002250","count":6},{"id":"GO:0006911","count":6}]},{"hash":"629790121399762248","title":"Unknown","description":"The top GO terms cover immune signaling (TLR4), neural processes (visual learning, locomotory behavior, pain perception), extracellular matrix organization (collagen fibril), and metabolism (electron transport chain), with additional cytolysis and defense terms. This wide mix lacks a single unifying function or pathway, so a concise, representative label isn\u2019t evident.","confidence":"","size":13,"edges":22,"triangles":14,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0034142","count":5},{"id":"GO:0008542","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0007626","count":5},{"id":"GO:0022900","count":4}]},{"hash":"1091445842129113906","title":"Ribosome biogenesis and RNA processing","description":"The cluster is marked by 90S preribosome assembly, rRNA processing (ITS1, 5.8S), and spliceosome assembly terms, indicating a core function in nucleolar ribosome production and RNA maturation; the cell division terms seem ancillary to growth rather than core function.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0000464","count":5},{"id":"GO:0006378","count":5}]},{"hash":"622567799836011864","title":"Immune cytokine signaling and T cell activation","description":"The top GO terms cluster around regulation of cytokine production (IL-2, type II interferon), T cell receptor signaling, and neutrophil homeostasis, pointing to core immune signaling and cytokine regulation. Some terms touching macrophage responses and other processes appear ancillary, but the dominant theme is immune cell signaling and cytokine regulation.","confidence":"Medium","size":13,"edges":58,"triangles":136,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0032743","count":7},{"id":"GO:0036006","count":6},{"id":"GO:0042053","count":6},{"id":"GO:0055118","count":6},{"id":"GO:0033159","count":6}]},{"hash":"597572169885949800","title":"Neuronal Amino Acid Transport and Signaling","description":"The cluster pulls together amino acid transport (glycine, proline, taurine) with modulation of synaptic transmission (dopamine uptake, glycinergic regulation, serotonin secretion), suggesting a cohesive theme around neuronal communication and amino acid homeostasis. The presence of development-related terms for brain structures (thalamus, adenohypophysis) and glial growth further supports a nervous-system context, though these are less central. Overall, the label captures the core idea of neurotransmitter-related transport and signaling in neurons and glia, with some peripheral developmental terms as outliers.","confidence":"Medium","size":13,"edges":51,"triangles":107,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1905847","count":11},{"id":"GO:0051583","count":11},{"id":"GO:0021794","count":11},{"id":"GO:0015824","count":11},{"id":"GO:0036233","count":11}]},{"hash":"142749008074764679","title":"Synaptic development and AMPA signaling","description":"The dominant GO terms point to synapse formation and function (postsynaptic density clustering, postsynaptic membrane assembly, AMPA receptor activity) and neural plasticity (learning). Supporting terms include lipid metabolism relevant to membrane composition (choline and cholesterol biosynthesis), which are crucial for synaptic membranes. Some terms also reflect neural development (retina development), reinforcing a neuronal context. Overall, the cluster centers on neuronal synapse development and AMPA-mediated signaling.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0019695","count":13},{"id":"GO:2000331","count":13},{"id":"GO:0097119","count":13},{"id":"GO:0006695","count":13},{"id":"GO:0010325","count":13}]},{"hash":"1160930587697547994","title":"Neurodevelopment and Embryogenesis","description":"The cluster centers on neural and broader developmental processes, with terms like forebrain development, neural tube closure, skeletal system development, and multicellular organism development, supported by transcription and cell cycle activity. A few terms (defense response to Gram-positive bacteria, hypoxia, proteolysis) are peripheral but do not override the developmental theme.","confidence":"Medium","size":13,"edges":56,"triangles":104,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006508","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1089962437074325600","title":"RNA Methylation and RNA Processing","description":"The cluster is dominated by RNA modification and processing activities, including tRNA wobble uridine modification, tRNA methylation, RNA guanine-N7 methylation, and mRNA capping, along with ribosomal subunit export, suggesting a core function in RNA maturation and ribosome biogenesis. Some metabolic terms may reflect broader regulation, but the RNA-focused terms are the strongest signal.","confidence":"High","size":13,"edges":21,"triangles":15,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002098","count":10},{"id":"GO:0035690","count":8},{"id":"GO:0006370","count":7},{"id":"GO:0016126","count":7},{"id":"GO:0030488","count":7}]},{"hash":"1074766376108630756","title":"Proteasome-Driven Turnover and ECM Remodeling in Cell Migration","description":"This cluster shows a coherent theme around proteostasis and extracellular matrix dynamics driving cell movement: ubiquitin-dependent protein catabolic process, proteasome assembly, negative regulation of ECM assembly, and positive regulation of metallopeptidase activity, all of which can modulate cell adhesion and substrate-based migration. Terms like substrate-dependent cell migration and heterotypic cell\u2013cell adhesion further support a migration/adhesion-focused function. Some terms (stamen formation, chlorophyll biosynthetic process) appear as outliers or cross-species annotations, but the dominant signals point to proteasome-mediated turnover coupled with ECM remodeling governing cell movement and remodeling processes.","confidence":"Medium","size":13,"edges":75,"triangles":256,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048455","count":7},{"id":"GO:0015995","count":7},{"id":"GO:0006511","count":7},{"id":"GO:0043248","count":7},{"id":"GO:0045123","count":6}]},{"hash":"158187514547380260","title":"NF-\u03baB/JNK inflammatory cytokine signaling","description":"The set includes GO terms for cytokine production, TNF production, NF-\u03baB activity, and JNK cascade, along with PI3K/AKT signaling, pointing to a cohesive role in immune activation and inflammatory responses. While there are peripheral terms related to development and antiviral regulation, the dominant theme is inflammatory signal transduction and cytokine production.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:0043491","count":6},{"id":"GO:0002741","count":5},{"id":"GO:0042535","count":5},{"id":"GO:0007275","count":5}]},{"hash":"828369071369836874","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":73,"triangles":238,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000184","count":9},{"id":"GO:0042273","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0000466","count":8},{"id":"GO:0000480","count":8}]},{"hash":"2195672339261176758","title":"Synaptic Spine Morphogenesis and Actin Remodeling","description":"The cluster is characterized by dendritic spine morphogenesis, filopodium and actin filament polymerization, and synaptic signaling pathways (Wnt and ephrin receptor signaling), along with long-term synaptic depression, all pointing to neuronal spine development and dynamic actin remodeling at synapses. A few apoptotic terms appear but do not define the cluster's core function.","confidence":"High","size":13,"edges":36,"triangles":41,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":6},{"id":"GO:0090263","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0046847","count":5},{"id":"GO:0050798","count":4}]},{"hash":"1075331087476599460","title":"Neural adhesion and axon regeneration with ECM remodeling","description":"The cluster centers on GO terms for neuron cell-cell adhesion, cell-matrix adhesion, collagen fibril organization, and peripheral nervous system axon regeneration, with angiogenesis also represented. This points to a theme of neural development/regeneration supported by extracellular matrix remodeling and vascularization, despite a few outlier terms such as complement activation and certain signaling pathway regulations. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007158","count":5},{"id":"GO:0007160","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0014012","count":4}]},{"hash":"1116603246307922213","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000390","count":2},{"id":"GO:0071033","count":2},{"id":"GO:0000973","count":2},{"id":"GO:0006283","count":2},{"id":"GO:0009561","count":2}]},{"hash":"962879581648118686","title":"Chromatin Modification and Cell Cycle Regulation","description":"These GO terms cluster around chromatin regulation (histone H3 acetylation and methylation) and transcriptional control (DNA-templated transcription, imprinting regulation), together with cell cycle processes (cell division, APC-dependent catabolic process). The presence of rRNA maturation suggests broader growth-related regulation. Although a few terms are obsolete and a cardiac morphogenesis term seems incidental, the core signal points to chromatin remodeling coordinating transcription with cell-cycle progression.","confidence":"High","size":13,"edges":69,"triangles":204,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043966","count":5},{"id":"GO:0006349","count":5},{"id":"GO:0071276","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0051573","count":4}]},{"hash":"1590097155892322613","title":"Actin Cytoskeleton Remodeling","description":"This cluster is dominated by GO terms related to actin dynamics, including lamellipodium and filament organization, actin bundle assembly, and plasma membrane tubulation, with additional signals pointing to regulation of Rho pathways. The presence of dendritic spine morphogenesis suggests neuronal actin remodeling as well, supporting a cohesive theme around actin-driven membrane protrusions and morphogenesis.","confidence":"High","size":13,"edges":63,"triangles":193,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0097320","count":11},{"id":"GO:0030032","count":11},{"id":"GO:0007015","count":11},{"id":"GO:0035023","count":11},{"id":"GO:0051017","count":11}]},{"hash":"33347737070547544","title":"Nuclear import/export and spindle/microtubule organization","description":"The GO terms largely reflect nucleocytoplasmic transport (nuclear import/export, ribosomal protein import, mRNA export, nuclear pore complex assembly) and mitotic spindle-related processes (astral microtubule organization), indicating a nucleus-centered transport and cell division function; intraciliary transport appears as a minor outlier.","confidence":"High","size":13,"edges":46,"triangles":74,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042176","count":9},{"id":"GO:0006610","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0006607","count":8},{"id":"GO:0006406","count":8}]},{"hash":"1535656772320779491","title":"Neuronal axon development and cytoskeleton dynamics","description":"The top terms cluster around axonogenesis in the peripheral nervous system, retrograde axonal transport, neurofilament assembly, and maintenance of microtubule polarity, all pointing to neuronal cytoskeleton and axon growth processes. Some accompanying terms (lens fiber development, muscle contraction) also reflect structural/cytoskeletal roles, but the dominant signal is neuronal cytoskeleton organization and axon development.","confidence":"High","size":13,"edges":76,"triangles":265,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0031443","count":13},{"id":"GO:0043000","count":13},{"id":"GO:0090343","count":13},{"id":"GO:0035105","count":13},{"id":"GO:1904714","count":13}]},{"hash":"573916721741953466","title":"Ribosome Biogenesis and Translation Machinery","description":"Based on GO terms, the cluster centers on ribosome-related processes and translation: GO:0006412 (translation) and GO:0042254 (ribosome biogenesis) are the top terms. Additional terms point to RNA modification and snoRNP assembly (box C/D snoRNP assembly), as well as RNA processing activities like pseudouridine synthesis of snRNA and rRNA, indicating a cohesive group involved in ribosome function and maturation. A few signaling terms (MAPK cascades) are present but likely less representative of the core function.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0042254","count":8},{"id":"GO:0046330","count":4},{"id":"GO:0000492","count":4},{"id":"GO:0031120","count":4}]},{"hash":"123517489540302266","title":"Neuronal axon cytoskeleton and transport","description":"This cluster is dominated by GO terms related to axon development, neurofilament assembly, retrograde axonal transport, and microtubule polarity, signaling a cohesive set of proteins involved in neuronal cytoskeleton organization and axonal trafficking. The presence of related cytoskeletal terms (and a few peripheral or related contexts) supports labeling as neuronal axon cytoskeleton and transport.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0031443","count":13},{"id":"GO:0043000","count":13},{"id":"GO:0090343","count":13},{"id":"GO:0035105","count":13},{"id":"GO:1904714","count":13}]},{"hash":"47188083034082094","title":"Synapse-associated actin remodeling and spine morphogenesis","description":"Actin cytoskeleton organization and actin filament bundle/lamellipodium assembly are prominent, with links to dendritic spine morphogenesis and synapse structural plasticity, all coordinated by Rho signaling and centrosome-related localization. The presence of neuronal synaptic terms and spine-related processes suggests a cohesive theme of actin-driven synaptic development and plasticity, potentially influencing neuronal behaviors such as vocalization. Confidence: High","confidence":"","size":13,"edges":65,"triangles":186,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051017","count":13},{"id":"GO:0030032","count":12},{"id":"GO:0051835","count":11},{"id":"GO:0051660","count":11},{"id":"GO:0035023","count":11}]},{"hash":"1690136271746526307","title":"Neuronal vesicle trafficking and dopamine signaling","description":"The strongest signals are in neuronal vesicle trafficking and signaling: regulation of synaptic vesicle exocytosis, dopamine secretion, and brain development. Additional terms related to endosomal pathways (multivesicular body size, ribophagy) and cell fate (apoptotic regulation) reinforce a theme of vesicle trafficking-related neuronal function rather than unrelated processes.","confidence":"High","size":13,"edges":23,"triangles":7,"max_degree":10,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:2000300","count":11},{"id":"GO:0010796","count":11},{"id":"GO:0031384","count":11},{"id":"GO:0007420","count":10},{"id":"GO:0071236","count":9}]},{"hash":"2200371504220491779","title":"Cell polarity and cytoskeleton organization","description":"This cluster has strong representation of actin cytoskeleton dynamics, centrosome localization, tight junction assembly, epithelial apical/basal polarity, microvillus assembly, basolateral membrane localization, and dendritic spine morphogenesis, all pointing to coordinated regulation of cell polarity with cytoskeletal remodeling in both epithelial and neuronal contexts.","confidence":"High","size":13,"edges":37,"triangles":57,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":13},{"id":"GO:0051835","count":12},{"id":"GO:0051660","count":12},{"id":"GO:0070830","count":12},{"id":"GO:0030036","count":11}]},{"hash":"1288807599424026776","title":"Fungal ER Protein Folding and Stress Response","description":"The cluster is dominated by GO terms related to ER-based protein folding and quality control (protein folding in ER, chaperone-dependent refolding, post-translational targeting to membrane) and stress management (negative regulation of cellular response to heat, redox homeostasis). The presence of fungal-specific processes (beta-glucan biosynthesis, karyogamy) suggests a fungal context, so the label centers on ER-associated folding and stress responses in fungi, with cell wall biogenesis and mating-related processes as related context.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1900035","count":11},{"id":"GO:0031204","count":11},{"id":"GO:0090084","count":11},{"id":"GO:0070389","count":11},{"id":"GO:0006260","count":11}]},{"hash":"2043189405659793956","title":"Ion Transport and Ionic Homeostasis","description":"The cluster shows strong enrichment for ion transport and homeostasis terms: sodium and potassium export, proton transmembrane transport, vacuolar acidification, and cell volume/homeostasis, with gastric acid secretion highlighting proton/pH regulation and cardiac conduction hinting at ion channel activity. This supports a unified theme of membrane transport and ionic/pH balance.","confidence":"High","size":13,"edges":20,"triangles":11,"max_degree":6,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0009651","count":5},{"id":"GO:0001696","count":4},{"id":"GO:0086092","count":3},{"id":"GO:0007035","count":3},{"id":"GO:0097623","count":3}]},{"hash":"1545778767762740501","title":"TNF-NF-\u03baB inflammatory signaling","description":"This cluster is dominated by terms related to TNF-mediated signaling and NF-kappaB regulation, including both negative and positive regulation of NF-kappaB activity, plus downstream ERK cascade involvement and type II interferon production. While a few terms touch membrane trafficking and localization, the core theme is inflammatory signaling networks activated by TNF and NF-kappaB pathways, indicating a cohesive immune signaling cluster.","confidence":"High","size":13,"edges":61,"triangles":138,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":6},{"id":"GO:0033209","count":6},{"id":"GO:2000009","count":4},{"id":"GO:1902072","count":4},{"id":"GO:1902306","count":4}]},{"hash":"2053265122314039767","title":"Heart development and cardiac muscle remodeling","description":"The cluster is rich in heart development (GO:0007507) and muscle stretch response (GO:0035994), with strong cell migration (GO:0016477) and Wnt signaling regulation (GO:0090090) signals, pointing to cardiac morphogenesis and remodeling of cardiac tissue in response to mechanical cues. The presence of proliferation and apoptotic regulation terms further supports developmental regulation of heart cells. Overall, the proteins likely participate in cardiac development and myocardial adaptation.","confidence":"High","size":13,"edges":24,"triangles":35,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016477","count":13},{"id":"GO:0008285","count":11},{"id":"GO:0043065","count":10},{"id":"GO:0090090","count":10},{"id":"GO:0098761","count":9}]},{"hash":"1051773862229089215","title":"Cilium and microtubule\u2013related cell cycle proteins","description":"This cluster centers on cytoskeletal and ciliary functions (epithelial cilium movement, microtubule anchoring, preprophase band assembly), pointing to microtubule dynamics and ciliogenesis. It also includes cell-cycle/DNA maintenance signals (DNA replication primer synthesis, recombinational repair) and some circadian terms, suggesting temporal regulation of division or genome maintenance. Overall, it groups proteins involved in cytoskeletal organization with cell-cycle and DNA maintenance roles, hence the label.","confidence":"Medium","size":13,"edges":10,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060287","count":1},{"id":"GO:0030307","count":1},{"id":"GO:0034453","count":1},{"id":"GO:2000314","count":1},{"id":"GO:0000913","count":1}]},{"hash":"570282547156955387","title":"Acetylation-Linked Biosynthesis","description":"Most enriched terms are acetylation-related (N-terminal and protein acetylation, histone acetylation, propionylation) and several biosynthetic processes (melatonin, arginine, mycothiol, glucosamine). This points to a theme of enzymes/modifiers involved in acetylation and diverse biosynthetic pathways, hence \"Acetylation-Linked Biosynthesis.\" ","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030187","count":12},{"id":"GO:0001525","count":12},{"id":"GO:0006041","count":12},{"id":"GO:0017198","count":12},{"id":"GO:0060358","count":12}]},{"hash":"828421872816978899","title":"ECM\u2013Integrin Adhesion and Angiogenesis Regulation","description":"The proteins in this cluster map strongly to adhesion and extracellular matrix interactions (cell adhesion, integrin-mediated signaling, collagen fibril organization) and to regulation of vascular processes (angiogenesis, endothelial chemotaxis, VEGF signaling). The synapse assembly term is less central but may reflect shared adhesion-related functions. Overall, the theme is ECM\u2013integrin\u2013adhesion with vascular growth regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0030199","count":5},{"id":"GO:0033631","count":5},{"id":"GO:0007155","count":5},{"id":"GO:0016525","count":5}]},{"hash":"1436020997213830919","title":"Mitotic cell cycle and DNA replication","description":"Reasoning: The dominant GO terms point to core mitotic processes and DNA synthesis, including cell division, sister chromatid biorientation, mitotic cell cycle, metaphase/anaphase transition, and DNA replication. There are also related processes like nuclear membrane reassembly and DNA integration; a couple of terms (endosome\u2013vacuole transport and ubiquitin-dependent ERAD) may reflect broader cellular context or annotation artifacts. Overall, the cluster centers on mitosis and genome duplication.","confidence":"High","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0031134","count":3},{"id":"GO:0032511","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0030433","count":2}]},{"hash":"1520751118352729742","title":"Neural development and synapse formation","description":"The strongest signals are neural-focused: positive regulation of synapse assembly, corpus callosum development, and axonal fasciculation. PI3K/AKT signaling and other terms reflect shared developmental signaling, with peripheral terms (vascular/ECM) present but less central. Overall, the cluster seems tied to neural development and synapse formation, with some broader developmental signaling context.","confidence":"Medium","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0022038","count":4},{"id":"GO:0010572","count":4},{"id":"GO:0043491","count":3},{"id":"GO:0090557","count":3}]},{"hash":"1355222036729585817","title":"Insulin signaling and heart development with cytoskeletal remodeling","description":"This cluster shows strong enrichment for insulin receptor signaling and PI3K/AKT pathways, alongside heart development and actin cytoskeleton organization, suggesting a coherent module where insulin signaling drives cardiac development and cytoskeletal dynamics. Additional signals like small GTPase pathways and JNK regulation provide broader signaling context, with mitochondrial fission and hyaluronan metabolism reflecting related remodeling processes. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0008286","count":6},{"id":"GO:0043491","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007264","count":6},{"id":"GO:0046329","count":5}]},{"hash":"688900075029856995","title":"Secretory vesicle trafficking and cell cycle regulation","description":"The cluster centers on secretory and vesicle trafficking processes, including ER-to-Golgi transport, COPII regulation, multivesicular body assembly, and exosomal secretion, with supporting hints from autophagy and EGFR signaling; a smaller emphasis on cell cycle/division suggests coordination with growth. ","confidence":"Medium","size":13,"edges":18,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0016236","count":2},{"id":"GO:1903542","count":2},{"id":"GO:0036258","count":2}]},{"hash":"1921288338978938485","title":"Innate Immune Response and Inflammation","description":"The cluster is dominated by innate immune terms such as acute-phase response, response to lipopolysaccharide, and classical complement activation, indicating a core theme of inflammation and antimicrobial defense; other developmental and morphogenesis terms likely reflect secondary or multi-functional annotations.","confidence":"High","size":13,"edges":18,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0044130","count":5},{"id":"GO:0006953","count":5},{"id":"GO:0003050","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0006958","count":4}]},{"hash":"742795785684788532","title":"Lens development and eye morphogenesis","description":"This cluster is dominated by terms related to lens and eye development, including lens fiber cell morphogenesis, differentiation, and development, as well as camera-type eye development and visual perception. These concordant terms suggest the proteins participate in lens formation and maturation rather than other cellular processes, and the obscure regulatory terms do not override this main signal. Therefore, \u201cLens development and eye morphogenesis\u201d is a concise and representative label.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043433","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0070309","count":1},{"id":"GO:0070306","count":1}]},{"hash":"2217598004771308308","title":"Unknown","description":"The top terms are highly diverse, ranging from signaling pathways (FGFR, GDNF receptor signaling) to organ development (CNS development, glomerular development, basement membrane) and tissue processes (innervation, colon epithelial migration) as well as seemingly unrelated processes (lipoteichoic acid biosynthesis). The network is sparse (max degree 1, few edges, no triangles), offering no single coherent function or theme to bind the cluster, so a reliable label cannot be assigned.","confidence":"","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0040037","count":4},{"id":"GO:0014846","count":4},{"id":"GO:0070395","count":4},{"id":"GO:0035860","count":4},{"id":"GO:0003094","count":4}]},{"hash":"86774585735443590","title":"Inflammation-driven angiogenesis and ECM remodeling","description":"Most terms cluster around vascular inflammation and remodeling: acute inflammatory response, angiogenesis, collagen fibril organization, vasodilation, and cell-matrix interactions. Signaling terms (Wnt, Hedgehog, and calcium signaling) suggest regulatory pathways coordinating endothelial behavior and smooth muscle interactions during vessel growth. The outlier short-term memory likely reflects annotation noise rather than a core cluster feature. Overall, the theme is inflammation-associated angiogenesis and extracellular matrix remodeling.","confidence":"High","size":13,"edges":19,"triangles":8,"max_degree":6,"top_function":"protein maturation","top_go_terms":[{"id":"GO:0007614","count":9},{"id":"GO:0002438","count":9},{"id":"GO:0045766","count":9},{"id":"GO:0014068","count":9},{"id":"GO:0030199","count":9}]},{"hash":"2086956004634270205","title":"Apoptosis and stress-response proteins","description":"This cluster is driven by terms tied to stress signaling and cell fate: apoptotic process, cellular responses to cAMP and hydrogen peroxide, and response to xenobiotics, which together suggest a module coordinating stress sensing with programmed cell death. The presence of corneocyte development hints at epithelial or skin-related roles, possibly linking barrier formation to stress responses. Overall, the functions point to a coherent, but diverse, stress-response network with apoptosis as a core outcome, giving a moderately confident, representative label.","confidence":"Medium","size":13,"edges":34,"triangles":30,"max_degree":11,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:1903507","count":5},{"id":"GO:0071320","count":5},{"id":"GO:0080111","count":5},{"id":"GO:0003335","count":5}]},{"hash":"458727118462605153","title":"Neural development and sensory behavior","description":"The cluster centers on neural-related developmental and behavioral processes, with terms like enteric nervous system development, regulation of astrocyte chemotaxis, sensory perception of pain, and grooming behavior. It also includes signaling-related terms (positive regulation of ERK1/2 cascade, negative regulation of dopamine receptor signaling) that can modulate neural activity and development. While there are occasional non-neural developmental terms (heart and metanephric glomerulus development) and other functions (defense response, saliva secretion), the neural development and sensory/behavioral themes predominate, suggesting these proteins collectively participate in neural development and behavior regulation via signaling pathways.","confidence":"Medium","size":13,"edges":24,"triangles":17,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":12},{"id":"GO:0007507","count":12},{"id":"GO:0042742","count":12},{"id":"GO:0046541","count":10},{"id":"GO:0072224","count":10}]},{"hash":"2206773304261026401","title":"Classical Complement Activation and Inflammation","description":"This cluster is dominated by GO terms related to the classical complement pathway, membrane attack complex activation, and inflammatory responses, including chemokine production and macrophage chemotaxis. A few terms touch lipid metabolism, but the strongest and most frequent signals point to immune activation via complement and inflammation.","confidence":"Medium","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":2},{"id":"GO:0001798","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0010884","count":1},{"id":"GO:0001970","count":1}]},{"hash":"978778415383918348","title":"Embryogenesis and organ morphogenesis","description":"The top GO terms cluster around embryonic development and organ formation\u2014left/right patterning, endocardial cushion/heart development, palate formation, cartilage morphogenesis, and placenta/endocrine development\u2014reflecting a cohesive theme of early developmental patterning and organogenesis.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0060536","count":7}]},{"hash":"1464008921614662441","title":"Steroid Hormone Biosynthesis and P450 Pathways","description":"The top GO terms cluster around steroid biosynthesis and P450-mediated oxidation, including ecdysone, aldosterone, bile acid, and brassinosteroid biosynthesis, as well as omega-hydroxylase P450 activity. This points to a coherent theme of steroid metabolism across different organisms, with possible downstream developmental effects. The remaining terms (developmental and stress-response) may reflect broader roles of steroids but do not outweigh the central biosynthetic theme.","confidence":"High","size":13,"edges":59,"triangles":157,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006697","count":11},{"id":"GO:0097267","count":11},{"id":"GO:0032342","count":11},{"id":"GO:0071615","count":11},{"id":"GO:0006699","count":11}]},{"hash":"1288359931946053357","title":"Neural signaling and development","description":"Top GO terms show a strong emphasis on neural signaling and nervous system development, including neuropeptide signaling, sensory perception of pain, grooming behavior, enteric nervous system development, and negative regulation of dopamine receptor signaling. Astrocyte chemotaxis suggests glial involvement in neural contexts. A couple of terms (saliva secretion and transepithelial chloride transport) relate to epithelial/secretory processes and may reflect broader tissue expression or shared components rather than core cluster function. Overall, the cluster best fits a neural signaling and development theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030321","count":13},{"id":"GO:0046541","count":12},{"id":"GO:0072224","count":12},{"id":"GO:0060160","count":12},{"id":"GO:0048484","count":12}]},{"hash":"2040795444931286720","title":"Mammary gland development and lactation","description":"The strongest GO terms cluster around mammary gland biology: alveolus development, mammary epithelial proliferation, and lactation, suggesting a module of genes involved in milk-producing gland development. Transcriptional regulation and cell-cycle control terms support the regulatory programs behind these processes, while a Leydig cell differentiation term appears less directly related. Overall, the dominant theme is mammary gland development and lactation.","confidence":"High","size":13,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0060749","count":4},{"id":"GO:0033327","count":4},{"id":"GO:0000320","count":3},{"id":"GO:0033598","count":3}]},{"hash":"1100795275981074281","title":"Embryonic morphogenesis and pattern formation","description":"The top GO terms cluster around organ and tissue development (palate roof formation, left-right patterning, hair follicle morphogenesis, endocrine system development, and EMT in heart cushion formation), indicating a developmental/morphogenetic theme. A minority of terms touch on RNA processing or transcription regulation, but the shared theme is embryonic morphogenesis and patterning.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0060021","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0031069","count":1}]},{"hash":"1537593632073081973","title":"Wound Healing and ECM Remodeling","description":"Enrichment for collagen fibril organization, proteolysis, integrin-mediated signaling, and keratinocyte migration points to extracellular matrix remodeling and skin wound repair as the dominant theme. The presence of wound healing and epidermal spreading terms, along with modulated growth factor responses (HGF, VEGF, BMP), suggests these proteins participate in epidermal regeneration and ECM signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":10},{"id":"GO:0006508","count":9},{"id":"GO:0051549","count":9},{"id":"GO:0007338","count":9},{"id":"GO:0007229","count":9}]},{"hash":"278310835063412026","title":"Mitochondrial Translation and Respiration","description":"The cluster is strongly enriched for translation-related terms, especially mitochondrial translation and initiation/termination, as well as the electron transport chain, indicating a core function in mitochondrial protein synthesis coupled to respiration. Some other terms (brain development, fibroblast proliferation) may be incidental, but the mitochondrial translation/respiration theme dominates. ","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0032543","count":3},{"id":"GO:0070124","count":1},{"id":"GO:0015968","count":1},{"id":"GO:0006415","count":1}]},{"hash":"401901584051038625","title":"Ciliogenesis and ciliary transition zone","description":"The top GO terms are dominated by cilia-related processes: cilium assembly, sperm axoneme assembly, and localization/assembly of proteins at the ciliary transition zone, including basal body docking to the plasma membrane. While there are differentiations and Wnt signaling terms present, they likely reflect cilia-linked developmental signaling roles rather than a separate non-ciliary process, making ciliogenesis and transition zone components the most coherent cluster theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":2},{"id":"GO:0090090","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0097711","count":1},{"id":"GO:0055007","count":1}]},{"hash":"1591407653690596608","title":"Neuronal sensory perception and GPCR signaling","description":"The top GO terms cluster around neural sensory processing across modalities (taste and vision), GPCR signaling, and glutamatergic synaptic transmission, with connects to behavior (locomotion) and memory. Although an electron transport term appears, the dominant signal is neural signaling and sensory perception, suggesting a coherent cluster of neuronal sensory processing and neurotransmission.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001580","count":8},{"id":"GO:0050909","count":8},{"id":"GO:0022900","count":4},{"id":"GO:0050908","count":4},{"id":"GO:0071257","count":4}]},{"hash":"1202276500700607434","title":"Dopaminergic Synaptic Transmission and Neuropeptide Signaling","description":"This cluster is dominated by GO terms related to neural signaling and dopamine pathways: dopaminergic synaptic transmission, neuropeptide signaling, regulation of dopamine receptor signaling, sensory perception of pain, and grooming behavior. It also includes enteric nervous system development and astrocyte-related chemotaxis, pointing to neural/glial interactions. A few terms (saliva secretion, metanephric glomerulus development, DN2 thymocyte differentiation) seem peripheral or pleiotropic, but the central theme remains neural signaling and dopaminergic modulation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":13},{"id":"GO:0072224","count":13},{"id":"GO:0060160","count":13},{"id":"GO:0048484","count":13},{"id":"GO:2000458","count":13}]},{"hash":"818077556524201974","title":"Taste perception proteins","description":"Based on the GO terms, the dominant signals are gustatory perception and detection of bitter taste, strongly pointing to a shared role in taste sensation. The remaining terms occur at low frequency and may reflect incidental annotations or multifunctionality, but they do not override the primary taste-related theme.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001580","count":11},{"id":"GO:0050909","count":11},{"id":"GO:0046597","count":1},{"id":"GO:0060349","count":1},{"id":"GO:0030282","count":1}]},{"hash":"1117778241013638310","title":"Developmental differentiation and cell adhesion","description":"The GO terms point to tissue development and differentiation across multiple systems (seminiferous tubule, osteoblast, chondrocyte, and cortical layer formation) with a strong emphasis on homophilic cell-cell adhesion. Supporting signaling aspects (calcium regulation, IGF receptor signaling, and CRH response) suggest developmental growth and regulation, while the electron transport chain reflects general cellular energy support. Overall, the cluster centers on developmental processes tied to cell adhesion across diverse tissues.","confidence":"Medium","size":13,"edges":14,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":13},{"id":"GO:0072520","count":13},{"id":"GO:0021819","count":13},{"id":"GO:0007204","count":13},{"id":"GO:0022900","count":13}]},{"hash":"1510652091959060764","title":"Dopaminergic Neuronal Signaling and Behavior","description":"Based on GO terms such as synaptic transmission, dopaminergic; neuropeptide signaling pathway; sensory perception of pain; grooming behavior; and enteric nervous system development, the cluster clearly centers on nervous system signaling and behavioral outputs, especially dopaminergic and neuropeptide pathways that influence behavior. A few terms like saliva secretion and metanephric glomerulus development appear less connected and may reflect annotation breadth, but the core theme remains neural signaling and behavior.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":13},{"id":"GO:0072224","count":13},{"id":"GO:0060160","count":13},{"id":"GO:0048484","count":13},{"id":"GO:2000458","count":13}]},{"hash":"890772199406831486","title":"Ceramide metabolism and sphingolipid signaling","description":"The cluster is dominated by ceramide-related terms (ceramide metabolic process, sphingolipid homeostasis, regulation of ceramide biosynthesis) and adiponectin-linked signaling, suggesting a core theme around sphingolipid metabolism and signaling. Additional GO terms point to ER stress responses and immune/inflammatory signaling (adaptive immune response, NF-kappaB regulation), indicating the cluster integrates lipid-mediated stress signals with immune and vascular contexts. While a synaptic transmission term appears, the strongest cohesion appears to be sphingolipid/ceramide metabolism with broader stress and immune signaling involvement.","confidence":"Medium","size":12,"edges":57,"triangles":142,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":2},{"id":"GO:0090156","count":2},{"id":"GO:0006672","count":2},{"id":"GO:1900060","count":2},{"id":"GO:0051968","count":2}]},{"hash":"1095771445965056059","title":"Coagulation and Complement Activation Cluster","description":"Dominant signals are immune and hemostasis related, with terms for classical and lectin complement activation, negative regulation of fibrinolysis, and intrinsic coagulation, plus cell-matrix adhesion and T-cell apoptosis regulation. Reproduction-related terms like single fertilization and behavior/hormone terms are present but appear less central to the core cluster function. Overall, the cluster reflects a coagulation/immune signaling module with some ancillary reproductive annotations.","confidence":"Medium","size":12,"edges":10,"triangles":4,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051918","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0001867","count":7},{"id":"GO:0007338","count":7},{"id":"GO:0006924","count":6}]},{"hash":"206873787929538309","title":"Golgi-ER Trafficking and Localization","description":"This cluster centers on Golgi-to-endosome and Golgi-to-plasma membrane transport, plus protein localization to the Golgi and ER organization, pointing to proteins involved in Golgi-ER trafficking and the secretory pathway. Neutrophil-related immune terms are present but secondary, so the main theme is vesicular transport within the Golgi-ER system.","confidence":"High","size":12,"edges":59,"triangles":171,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006895","count":2},{"id":"GO:0000042","count":2},{"id":"GO:0043001","count":2},{"id":"GO:1990266","count":1},{"id":"GO:0050832","count":1}]},{"hash":"1395315348944460251","title":"Glutamatergic GPCR Visual Signaling","description":"This cluster is dominated by terms related to G protein-coupled receptor signaling, especially PLC-activating GPCR pathways, and glutamatergic synaptic transmission, with multiple terms pointing to light perception and visual processing. The combination suggests neuronal signaling in vision-related circuits, supported by calcium/import and GPCR signaling links. Some terms (like electron transport) may reflect neuronal energy needs but do not define the core theme. Overall, it highlights Glutamatergic GPCR signaling in visual neurons.","confidence":"High","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030818","count":12},{"id":"GO:0090280","count":12},{"id":"GO:0007206","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0050908","count":12}]},{"hash":"1878945393516852755","title":"Secretory pathway and membrane biogenesis","description":"Based on the dominant GO terms, including positive regulation of ER exit, regulation of Golgi to plasma membrane transport, and GPI anchor biosynthesis, the cluster appears enriched for secretory pathway processes and membrane biogenesis. The rhabdomere membrane biogenesis term also points to membrane assembly in specialized cells. While inflammatory and VEGF-related terms suggest context in multicellular signaling, the core theme centers on secretory trafficking and membrane construction.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070863","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0010575","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1003851387584057163","title":"Neuropeptide signaling and inflammatory responses","description":"The cluster is enriched for neuropeptide signaling (GO:0007218) and several immune/inflammatory related responses (to lipopolysaccharide, leukotriene production) as well as feeding-related signaling (response to food) and retinoic acid signaling, suggesting a link between neural signaling and inflammatory/immune processes. The ER protein folding and autophagosome assembly terms imply concurrent cellular stress response roles that can accompany neuroimmune signaling. Overall, a cohesive theme of neuropeptide signaling intertwined with inflammatory and metabolic responses.","confidence":"Medium","size":12,"edges":10,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0000045","count":1},{"id":"GO:0034975","count":1},{"id":"GO:0043085","count":1}]},{"hash":"1900142587416416884","title":"ER network organization and nuclear envelope dynamics","description":"The cluster\u2019s GO terms are dominated by endoplasmic reticulum processes (ER tubular network organization, ER inheritance, ER stress response) and nuclear envelope-related events (nuclear pore complex assembly, mitotic nuclear membrane reassembly), with ER-dependent peroxisome organization reinforcing an ER-centric theme. A few terms about taste perception and abscisic acid response appear peripheral but do not override the core ER/nuclear envelope connection.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071786","count":1},{"id":"GO:0032596","count":1},{"id":"GO:0050916","count":1},{"id":"GO:0048309","count":1},{"id":"GO:0009737","count":1}]},{"hash":"479036441316246250","title":"Unknown","description":"The cluster shows a very mixed set of GO terms across endocytosis, metal/folate transport, and development in diverse organisms, with no clear shared function. While receptor-mediated endocytosis and transferrin/iron transport appear, other terms describe chondrocyte development, behavior, and plant meristem growth, preventing a cohesive functional label.","confidence":"","size":12,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006898","count":2},{"id":"GO:0035641","count":2},{"id":"GO:0002063","count":2},{"id":"GO:0035609","count":1},{"id":"GO:0017186","count":1}]},{"hash":"2036718557145984940","title":"Neurotransmitter GPCR Signaling","description":"Based on the top GO terms, the proteins are enriched for G protein-coupled receptor signaling and downstream second messenger pathways (e.g., dopamine receptor signaling, intracellular signal transduction, and GPCR signaling regulation). The presence of histamine and glucagon response terms further supports a theme of neurotransmitter/hormone receptor\u2013mediated signaling, despite a few developmental terms that are less connected. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071420","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0039021","count":1},{"id":"GO:0035556","count":1},{"id":"GO:0072513","count":1}]},{"hash":"1171637410920572863","title":"Unknown","description":"The terms span diverse processes\u2014including cell division, oxidative stress response, innate immunity, plant hormone signaling, steroid receptor assembly, and retinal development\u2014without a single cohesive theme, so there isn\u2019t a clear functional label for this cluster.","confidence":"","size":12,"edges":9,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0070301","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0046548","count":4}]},{"hash":"247812653604837670","title":"NAD/NADP metabolism and development","description":"Top GO terms include NADP+ biosynthesis and NAD+ metabolic process, indicating a core metabolic theme, alongside development-related terms like multicellular organism development and gastrulation and growth signals such as cell proliferation and phosphorylation. This suggests a cluster where NAD(P) metabolism interfaces with developmental processes, justifying the label. ","confidence":"Medium","size":12,"edges":27,"triangles":19,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0016575","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0008283","count":3}]},{"hash":"1427439240006750663","title":"Neuronal signaling and vesicle trafficking","description":"The cluster shows a coherent emphasis on neuronal development and synaptic function: brain development, small GTPase\u2013mediated signaling, EGFR signaling, neurotransmitter receptor transport to the postsynaptic membrane, endocytosis, and regulation of synaptic vesicle exocytosis. While a couple of terms are obsolete or related to non-neuronal processes, the dominant themes point to neuronal signaling and vesicle cycling at synapses, including endocytosis and cytoskeleton/cell polarity aspects relevant to synaptic architecture. This makes a Neuronal signaling and vesicle trafficking label appropriate and representative.","confidence":"High","size":12,"edges":51,"triangles":108,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":8},{"id":"GO:0007264","count":7},{"id":"GO:0007173","count":7},{"id":"GO:0098887","count":7},{"id":"GO:0006897","count":7}]},{"hash":"2067073687117140979","title":"Intracellular trafficking and snoRNP assembly","description":"This cluster is dominated by GO terms for vesicle trafficking and ER-Golgi transport (ER to Golgi vesicle transport, vesicle fusion with Golgi, intracellular transport), plus endosome-to-vacuole transport, which suggests a core of proteins involved in the secretory pathway. The presence of box C/D snoRNP assembly indicates additional involvement in nucleolar ribonucleoprotein biogenesis. Together, these points imply a group of proteins linked to vesicular trafficking and ribonucleoprotein assembly, with some ancillary signals related to cell cycle or immune response annotations likely reflecting multifunctionality. ","confidence":"Medium","size":12,"edges":59,"triangles":166,"max_degree":11,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000492","count":4},{"id":"GO:0006886","count":4},{"id":"GO:0048280","count":4},{"id":"GO:0032781","count":4}]},{"hash":"1154282078281724403","title":"DNA replication and recombination repair cluster","description":"Top GO terms show strong representation of DNA replication (including unwinding) and multiple recombination/repair processes (SDSA double-strand break repair, heteroduplex formation, meiotic recombination) as well as telomere maintenance via recombination. A few terms refer to vesicle transport and development, but the dominant theme is genomic maintenance through replication and recombination. Therefore this label captures the core function of the cluster.","confidence":"Medium","size":12,"edges":19,"triangles":15,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006268","count":4},{"id":"GO:0045003","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0048701","count":3}]},{"hash":"2090529544357722512","title":"Innate immune and inflammatory responses","description":"Based on the Top Terms, the cluster is driven by innate immune and inflammatory processes (innate immune response, inflammatory response, defense against bacteria/virus). While there are a few development and transcription regulation terms present, the strongest and most recurrent signals point to host defense and inflammatory signaling as the core function of this group. Confidence in this theme is moderate given the presence of several peripheral terms that may reflect multifunctional proteins or annotation noise.","confidence":"Medium","size":12,"edges":19,"triangles":17,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0072224","count":2}]},{"hash":"235393367541827537","title":"Spliceosome-Driven mRNA Processing and Silencing","description":"The top GO terms cluster around mRNA maturation and post-transcriptional regulation\u2014splicing via the spliceosome, regulation of splicing, mRNA export, polyadenylation, and miRNA-mediated gene silencing with effects on translation initiation. This indicates a cohesive theme of pre-mRNA processing and downstream gene-silencing pathways, despite some obsolete terms. ","confidence":"High","size":12,"edges":45,"triangles":78,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":8},{"id":"GO:0006378","count":6},{"id":"GO:0000381","count":5},{"id":"GO:0048026","count":5},{"id":"GO:1900363","count":5}]},{"hash":"1168471406567620460","title":"DNA Damage Response and Cell Cycle Regulation","description":"This cluster's top GO terms center on DNA damage signaling and p53-mediated arrest (GO:0006977), with negative regulation of serine/threonine kinase activity (GO:0071901) suggesting modulation of cell cycle checkpoints. Additional terms reflect stress responses (GO:0009408 heat) and growth/export regulation (GO:0030307, GO:0046827, GO:0051683), indicating a cohesive group involved in sensing stress and coordinating cell cycle control, despite some heterogeneous terms.","confidence":"Medium","size":12,"edges":43,"triangles":83,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006977","count":5},{"id":"GO:0071901","count":5},{"id":"GO:0009408","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0034766","count":3}]},{"hash":"206461974098555838","title":"RNA processing and mRNA turnover","description":"This cluster is enriched for RNA metabolism and gene expression control terms, including nuclear import, spliceosome assembly, rRNA maturation, transcription termination, histone mRNA metabolism, and P-body\u2013associated mRNA decapping. The presence of stress-response terms (water deprivation, abscisic acid) further suggests regulation of RNA processing and turnover under stress. Together, these terms point to a cohesive role in RNA maturation and mRNA decay pathways.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0051170","count":12},{"id":"GO:0000245","count":12},{"id":"GO:1990141","count":12},{"id":"GO:0030490","count":12},{"id":"GO:0006369","count":12}]},{"hash":"1879638155488590226","title":"ER-Golgi trafficking and protein quality control","description":"Enriched for ER-to-Golgi vesicle transport, SNARE complex disassembly, ER stress response, and protein ubiquitination, suggesting a cluster of proteins involved in secretory pathway trafficking and proteostasis; some tissue-specific terms may reflect broader roles of these proteins.","confidence":"Medium","size":12,"edges":55,"triangles":137,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":2},{"id":"GO:0035494","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0060263","count":2},{"id":"GO:0060047","count":2}]},{"hash":"1564222129807587228","title":"DNA Damage Response and Apoptosis","description":"The cluster groups proteins involved in DNA damage signaling, ubiquitin-mediated protein processing, and apoptosis, including deubiquitination, ERAD, and gamma radiation response, with translation and cell-number homeostasis as supporting processes. This combination points to a core theme of cellular stress handling and fate decisions when DNA damage occurs.","confidence":"Medium","size":12,"edges":59,"triangles":156,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":2},{"id":"GO:0008630","count":2},{"id":"GO:0071897","count":2},{"id":"GO:0010332","count":2},{"id":"GO:0030433","count":2}]},{"hash":"637873885112606545","title":"Multisystem Development and Immune Signaling","description":"The GO terms point to diverse developmental processes across multiple tissues (eye cornea, endoderm, atrial septum, enteric nervous system), suggesting proteins involved in lineage specification and organogenesis. The presence of immune-related terms (IL-1\u03b2 production, IL-4 response, B cell differentiation regulation) indicates additional immunomodulatory roles. Taken together, the cluster appears to center on broad developmental functions with immunoregulatory aspects rather than a single tissue-specific function.","confidence":"Medium","size":12,"edges":57,"triangles":166,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0061303","count":5},{"id":"GO:0050718","count":5},{"id":"GO:0006407","count":4},{"id":"GO:0007493","count":4},{"id":"GO:0045654","count":4}]},{"hash":"2281403212148577293","title":"Innate Immune Signaling and Inflammatory Cell Death","description":"This cluster is dominated by GO terms for innate immune response, antiviral defense (defense against virus, dsRNA response), and inflammatory processes (inflammatory response, pyroptotic inflammatory response) along with signals like TLR4 signaling. Ubiquitination is a common regulatory layer in these pathways, and apoptosis is also represented, supporting a theme of innate immune activation coupled to inflammatory cell death. A single term about mitotic spindle assembly is likely incidental to the main immune-focused functions.","confidence":"High","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016567","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0070269","count":10},{"id":"GO:0006915","count":10},{"id":"GO:1990001","count":10}]},{"hash":"1015140941114574282","title":"DNA replication, transcription, and chromatin remodeling","description":"The cluster combines DNA-templated transcription, RNA polymerase II promoter initiation, DNA replication, and histone-related chromatin remodeling (acetylation/exchange), suggesting coordinated regulation of gene expression through chromatin state and genome maintenance. Though ribosome biogenesis and SOS response appear, the core signal points to nuclear processes governing transcription and DNA repair/replication.","confidence":"High","size":12,"edges":63,"triangles":192,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0043968","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043486","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006289","count":2}]},{"hash":"821263617088018171","title":"NOD2 NF-kB Innate Immunity and Stress","description":"The top GO terms point to innate immune signaling via the NOD2 pathway and regulation of NF-kappaB activity, suggesting a core of inflammatory signaling. Other terms indicate protein turnover (proteolysis, deglycosylation) and cellular stress responses (heat, mechanosensory pain detection, pinocytosis, adipogenesis), implying a cluster that centers on innate immunity with broader stress-related processes. However, several terms are only loosely connected, so the label is best described as representative rather than exclusively cohesive.","confidence":"Medium","size":12,"edges":8,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0006517","count":2},{"id":"GO:0006559","count":2},{"id":"GO:0033345","count":2}]},{"hash":"1231420213142561550","title":"Neural development and stress-response signaling","description":"The cluster is enriched with brain development terms, notably cerebral cortex development and corpus callosum development, plus axon regeneration, suggesting a core role in neural development. It also includes apoptosis- and stress-related terms such as intrinsic apoptotic signaling in response to ER stress and negative regulation of the JNK cascade, pointing to coordinated cellular stress responses. Additional signals touch on DNA damage response (mitotic intra-S checkpoint signaling and meiotic DSB regulation), indicating integration of development with genomic stress pathways; a transcriptional regulation term by galactose appears peripheral. Overall, the dominant theme is neural development intertwined with stress-response signaling.","confidence":"Medium","size":12,"edges":38,"triangles":51,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":12},{"id":"GO:0070059","count":12},{"id":"GO:0046329","count":12},{"id":"GO:0072428","count":12},{"id":"GO:0021987","count":12}]},{"hash":"318356296475950423","title":"Developmental Morphogenesis Across Tissues","description":"The top GO terms point to morphogenesis in multiple tissues (uterus, coronary artery, Sertoli cell barrier) and to development of neuronal/immune cell structures (dendrites, dendritic spines). A few terms also touch chromatin regulation, which often underpins developmental gene expression. Overall, the cluster appears to reflect broad developmental/morphogenetic processes spanning diverse tissues rather than a single, cohesive pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901726","count":1},{"id":"GO:0097026","count":1},{"id":"GO:0061038","count":1},{"id":"GO:0034630","count":1},{"id":"GO:0060982","count":1}]},{"hash":"1721526330498085205","title":"Cardiac and neural development regulators","description":"The cluster centers on heart development and cardiac hypertrophy, but also includes neuronal functions such as sensory neuron axon guidance and excitatory postsynaptic potential, plus transcriptional and kinase regulation. This points to regulatory proteins involved in development and signaling across both cardiovascular and nervous system contexts.","confidence":"Medium","size":12,"edges":6,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0014898","count":3},{"id":"GO:0042127","count":3}]},{"hash":"1629864455591761787","title":"DNA Replication and Ribosome Biogenesis","description":"Core terms center on DNA replication, DNA recombination, and ribosome biogenesis/translation initiation, suggesting a cluster of proteins involved in genome maintenance and the protein synthesis machinery. While a few GO terms touch on stress responses (ER stress\u2013induced apoptosis) and cytoskeletal regulation, these appear less central to the dominant theme, making 'DNA replication and ribosome biogenesis' an appropriate, concise label that captures the main shared function among proteins in this cluster.","confidence":"Medium","size":12,"edges":15,"triangles":5,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0001731","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0016575","count":1}]},{"hash":"1005006233203307366","title":"Germline gene expression and genome maintenance","description":"The cluster combines transcription/translation machinery (translation, ribosome biogenesis, tRNA transcription, RNA-templated transcription), protein regulation and quality control (protein sumoylation, ubiquitin-dependent pathways), genome maintenance (nucleotide-excision repair), and germline-specific processes (spermatogenesis) with apoptosis, suggesting a cohesive theme of gene expression coupled to genome integrity and germline quality control. ","confidence":"Medium","size":12,"edges":56,"triangles":137,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":3},{"id":"GO:0070911","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0042797","count":2}]},{"hash":"1492057599456230720","title":"Development and Morphogenesis Cluster","description":"The top GO terms emphasize regulation of cell proliferation, cell migration, morphogenesis, and cell fate decisions (endodermal fate, oocyte localization), pointing to a developmental/morphogenetic program. Other terms reflect general RNA processing and ribosomal protein import, suggesting housekeeping activities that are common but not defining the cluster; overall, the cluster centers on development and morphogenesis with some incidental immune and basic cellular processes.","confidence":"Medium","size":12,"edges":18,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0006397","count":4},{"id":"GO:0060769","count":4},{"id":"GO:0045087","count":3}]},{"hash":"2080412237262704550","title":"Developmental transcriptional regulators","description":"This cluster centers on embryonic development and organogenesis, as shown by GO terms like embryonic skeletal system development, organ induction, multicellular organism development, and inner ear morphogenesis. It also highlights regulation of transcription, indicating these proteins act as transcriptional regulators coordinating developmental programs. The combined emphasis on development and transcriptional control suggests a cohesive role in orchestrating organ formation.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048706","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0001759","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0006355","count":2}]},{"hash":"2086960694798152995","title":"MAPK/ERK signaling regulation and cell-cycle control","description":"The top GO terms show strong enrichment for negative regulation of the ERK1/ERK2 cascade and related MAPK signaling, which points to regulation of signaling pathways. Additional terms touch on T cell receptor signaling, cell growth rate, exit from mitosis, and development, suggesting a broader theme of signaling control linked to cell cycle and development, with some immune and host-interaction contexts. While there are a few outliers (mRNA capping, habituation, symbiont-mediated JAK-STAT suppression), the dominant pattern is regulation of signaling pathways affecting growth, division, and development. Confidence: Medium","confidence":"","size":12,"edges":62,"triangles":182,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":11},{"id":"GO:0070373","count":11},{"id":"GO:0050860","count":11},{"id":"GO:0061388","count":10},{"id":"GO:0001701","count":10}]},{"hash":"459902377460293611","title":"Rho GTPase\u2013driven cytoskeletal remodeling and migration","description":"The top GO terms cluster around actin-based structures (filopodium/lamellipodium assembly), small GTPase signaling (Rho) and regulation of integrin activation, all pointing to coordinated cytoskeletal remodeling and cell movement. This explains the emphasis on cell migration and adhesion, with some immune-related terms (B cell homeostasis/affinity maturation) reflecting broader roles in immune cell trafficking rather than a different primary function. Overall, the common thread is actin dynamics driving motility and adhesion.","confidence":"High","size":12,"edges":10,"triangles":1,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0046847","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0001782","count":7},{"id":"GO:0098761","count":7},{"id":"GO:0007264","count":7}]},{"hash":"1952933246972108296","title":"Embryonic Development and Organogenesis","description":"The cluster shows GO terms across various embryonic and tissue formation processes\u2014left/right patterning, heart/right EMT in endocardial cushion formation, placenta-associated differentiation, cartilage morphogenesis, placental trophoblast development, pancreatic cell development, and eye development\u2014as well as adhesion and growth regulation. This points to a general theme of embryonic development and organ formation rather than a single, narrow pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2}]},{"hash":"56061333020541961","title":"Actin cytoskeleton remodeling and lamellipodium assembly","description":"This cluster centers on actin dynamics and protrusive structures (lamellipodium), with terms for actin filament capping and depolymerization, and positive regulation of cell migration, alongside microtubule organization and signaling (EGFR pathway, cAMP response). A platelet secretion term may reflect cytoskeletal-linked vesicle processes, but the dominant theme is actin-driven remodeling and migration.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031122","count":2},{"id":"GO:0036297","count":1},{"id":"GO:0070560","count":1},{"id":"GO:0010763","count":1},{"id":"GO:0007173","count":1}]},{"hash":"2281686210821413506","title":"Neural development and apoptotic signaling","description":"The top GO terms center on brain development such as cerebral cortex and corpus callosum development, and axon regeneration, suggesting a neural development theme. Intertwined are terms for apoptosis and stress responses (ER-stress\u2013induced intrinsic apoptotic signaling, negative regulation of JNK cascade, negative regulation of anoikis), indicating proteins that coordinate neuronal development with cell-survival and stress signaling. The inclusion of a mitotic intra-S DNA damage checkpoint signal also points to cell-cycle control relevant to neural progenitors. Overall, this cluster seems to reflect proteins involved in neural development with links to apoptosis and stress regulation.","confidence":"Medium","size":12,"edges":21,"triangles":14,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":12},{"id":"GO:0070059","count":12},{"id":"GO:0046329","count":12},{"id":"GO:0072428","count":12},{"id":"GO:0021987","count":12}]},{"hash":"790917274909616472","title":"Chromatin Remodeling and Transcription Regulation","description":"This cluster is dominated by GO terms tied to chromatin structure and transcription control\u2014chromatin remodeling, nucleosome disassembly, and regulation of transcription via RNA polymerase II, including histone acetylation, indicating an epigenetic/regulatory protein cluster. The presence of host-mediated activation of viral transcription hints at transcriptional regulatory capacity; despite some obsolete terms, the core theme is chromatin dynamics and transcription regulation.","confidence":"Medium","size":12,"edges":24,"triangles":16,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0090043","count":4},{"id":"GO:0006990","count":4},{"id":"GO:0005987","count":4},{"id":"GO:0044109","count":4},{"id":"GO:0035066","count":4}]},{"hash":"1184840597813237238","title":"Phosphatase-regulated Development and Metabolism","description":"This cluster shows enrichment for dephosphorylation-related GO terms (peptidyl-tyrosine dephosphorylation; dephosphorylation) along with diverse developmental (brain development; intestinal epithelial cell development) and metabolic (glycolytic process; L-serine biosynthetic process) processes, plus autophagy and DNA damage response regulation. The common thread likely reflects phosphatase-driven signaling coordinating growth, energy metabolism, and cellular stress responses across tissues.","confidence":"Medium","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"autophagy","top_go_terms":[{"id":"GO:0035335","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0016311","count":6},{"id":"GO:0045730","count":6},{"id":"GO:0006096","count":6}]},{"hash":"1631328545425566378","title":"Organ Development and Neural Signaling","description":"This cluster links broad developmental roles (angiogenesis, heart development, multicellular organism development) with neural processes (Schwann cell development, long-term synaptic potentiation, visual perception) and signaling regulation (peptidyl-threonine phosphorylation), plus basic cell-cycle and apoptotic processes. It suggests a theme of developmental programs that encompass neural tissues and signaling.","confidence":"Medium","size":12,"edges":20,"triangles":13,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":12},{"id":"GO:0010800","count":12},{"id":"GO:0014044","count":12},{"id":"GO:0007507","count":12},{"id":"GO:0007601","count":12}]},{"hash":"1785360334936599392","title":"Rho-GTPase signaling and cytoskeletal dynamics","description":"The top GO terms point to regulation of GTPase activity (including Rho), negative regulation of Rho signaling, ephrin receptor signaling, cell migration, and components of the cytoskeleton, with additional signals related to spindle assembly and cell cycle. This suggests a common theme of signaling pathways that control cytoskeletal remodeling and cell movement, sometimes intersecting with mitotic processes and endocytosis. The label emphasizes the central role of Rho-family GTPase regulation in these proteins\u2019 functions, keeping the name specific yet representative.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":3},{"id":"GO:1901187","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0035024","count":3}]},{"hash":"711320194901237187","title":"Neural development and progenitor proliferation","description":"GO terms are dominated by nervous system development, neural progenitor differentiation, and brain region formation (cortex, habenula, oligodendrocyte lineage), with additional entries on transcriptional regulation and cell-cycle checkpoints in proliferating neural cells. The shared theme is neural development and progenitor proliferation, hence the name.","confidence":"High","size":12,"edges":14,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0033314","count":2},{"id":"GO:0060019","count":2},{"id":"GO:0070445","count":2}]},{"hash":"2113808272651284563","title":"Neural development and cytoskeleton dynamics","description":"Dominant GO terms point to neural development (brain development, regulation of axon extension) and cytoskeleton remodeling (cytoskeleton organization, actin filament bundle assembly), suggesting the cluster centers on neural growth and cytoskeletal regulation. While several catabolic processes appear among the terms, the consistent neural/cytoskeletal signals justify this labeling.","confidence":"High","size":12,"edges":44,"triangles":81,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009442","count":3},{"id":"GO:0007010","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0006146","count":2},{"id":"GO:0030516","count":2}]},{"hash":"423099049205411828","title":"Ion Transport and Golgi Glycosylation","description":"The top GO terms cluster around membrane transport (various ion translocations and export) and Golgi-based glycosylation (GDP-fucose import, fucosylation), suggesting proteins involved in moving ions/metabolites across membranes and processing fucose-containing glycans. A development term is present but not central to the overall theme, so the core association is membrane transport plus Golgi glycosylation activities.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0015739","count":4},{"id":"GO:0072205","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0032973","count":3}]},{"hash":"1850104077679722151","title":"Embryonic morphogenesis and neural development","description":"The top GO terms point to widespread embryonic organ morphogenesis (palate, digits, limbs, heart outflow tract, skeletal system) and neural differentiation (cerebral cortex regionalization, neuronal and visceral motor neuron differentiation), indicating a cluster of proteins involved in early developmental processes across multiple tissues and neural specification.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":7},{"id":"GO:0042733","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0021796","count":5},{"id":"GO:0035116","count":5}]},{"hash":"1307769870625257521","title":"Unknown","description":"The top GO terms cover a wide and diverse set of processes (from viral release and defense against bacteria to peptidoglycan catabolism, electron transport, and locomotion) with no clear, single biological theme tying the proteins together. This lack of a cohesive function makes a specific, intuitive label inappropriate.","confidence":"","size":12,"edges":35,"triangles":42,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":12},{"id":"GO:0019835","count":12},{"id":"GO:0019076","count":12},{"id":"GO:0009253","count":12},{"id":"GO:0007194","count":12}]},{"hash":"2299724421979231171","title":"Protein acetylation and chromatin regulation","description":"The cluster is enriched for multiple acetylation-related GO terms (N-terminal and lysine acetylation variants), suggesting a common role in post-translational modification. The presence of subtelomeric heterochromatin formation and centromeric cohesion hints at chromatin organization connections, while melatonin biosynthesis and related metabolic terms can relate to acetyltransferase activity using acetyl-CoA. Overall, the shared theme appears to be acetylation-linked regulation of proteins and chromatin states.","confidence":"Medium","size":12,"edges":26,"triangles":22,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0018003","count":6},{"id":"GO:0030187","count":4},{"id":"GO:0018002","count":4},{"id":"GO:0071962","count":4},{"id":"GO:0006044","count":4}]},{"hash":"312356107738715737","title":"NF-kappaB signaling and stress response regulators","description":"The cluster shows a mix of gene expression (translation, RNA-templated transcription) and signaling/modulation terms (positive regulation of NF-kappaB signaling, protein phosphorylation, regulation of GTPase activity) along with stress and apoptotic notes (positive regulation of apoptotic process, ER stress responses, morphine response). This suggests proteins that coordinate transcriptional/translational control with signaling pathways and stress responses, particularly NF-kappaB\u2013related regulation.","confidence":"Medium","size":12,"edges":34,"triangles":30,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0001172","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0006468","count":2}]},{"hash":"708004835270631880","title":"Lens development and eye morphogenesis","description":"This cluster is dominated by GO terms related to lens fiber cell morphogenesis, differentiation, and development, as well as lens development in the camera-type eye and visual perception. Together these terms point to a shared role in lens formation and ocular structure, with epithelial morphogenesis as a supporting theme, while the metabolic terms appear ancillary. Confidence: High","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":5},{"id":"GO:0070309","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0070307","count":4},{"id":"GO:0002009","count":4}]},{"hash":"1936419919597229049","title":"Central Carbon Metabolism and Stress Response","description":"This cluster centers on core energy pathways\u2014glycolysis and the TCA cycle (including oxaloacetate metabolism)\u2014and includes regulatory/response terms such as hypoxia, nutrient status, and cAMP signaling. The combination suggests a cohesive theme of central carbon metabolism coupled with metabolic adaptation and stress responses, with some plant-specific terms (photorespiration regulation) reinforcing the metabolic context. ","confidence":"High","size":12,"edges":50,"triangles":126,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0006099","count":6},{"id":"GO:0006096","count":6},{"id":"GO:0006107","count":4},{"id":"GO:0001666","count":4}]},{"hash":"2018018982368157420","title":"Rho/Rac/Rap GTPase Signaling","description":"The cluster's top GO terms focus on regulation and activation of small GTPases (Rho, Rac, Rap), indicating a shared role in GTPase signaling that governs cytoskeleton dynamics and cell behavior; a few morphogenesis terms suggest developmental contexts where this signaling operates, supporting the overall theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0090630","count":2},{"id":"GO:0035022","count":2},{"id":"GO:0003209","count":2},{"id":"GO:0007296","count":2}]},{"hash":"2276942041900158821","title":"RNA and protein methylation","description":"The cluster is dominated by GO terms for RNA methylation (rRNA, mRNA cap, m7G methylation) and various protein/ histone methylations (arginine and lysine methylation, histone H4-R3 methylation), suggesting a shared theme of methyltransferase activity across nucleic acids and proteins; some related terms (cobalamin biosynthesis, growth/senescence) may reflect broader methylation-linked metabolism.","confidence":"Medium","size":12,"edges":24,"triangles":30,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":7},{"id":"GO:0031167","count":7},{"id":"GO:0006370","count":6},{"id":"GO:0043985","count":6},{"id":"GO:0019919","count":6}]},{"hash":"1191201388244173680","title":"Glycosaminoglycan Biosynthesis and Xenobiotic/Hormone Metabolism","description":"The cluster is enriched for proteoglycan biosynthesis terms (heparan/heparin and chondroitin sulfate) indicating extracellular matrix/glycosaminoglycan production, while also showing broad small-molecule metabolism signals (xenobiotic, bile acid, catecholamine, and thyroid hormone metabolism) and a developmental term (embryonic neurocranium morphogenesis). This suggests a cohesive theme around ECM/glycosaminoglycan synthesis linked to hepatic or developmental metabolic processes rather than a single isolated pathway.","confidence":"Medium","size":12,"edges":51,"triangles":120,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045600","count":5},{"id":"GO:0030210","count":5},{"id":"GO:0006805","count":5},{"id":"GO:0006477","count":5},{"id":"GO:0030573","count":5}]},{"hash":"2216162907633186133","title":"RNA Methylation and Translational Regulation","description":"This cluster is dominated by GO terms for RNA modification and processing, notably tRNA and rRNA methylation, plus related protein methylation and RNA maturation steps. The presence of mitochondrial tRNA methylation and aminoacylation terms, along with regulation of translational fidelity, suggests a coherent module of RNA-modifying enzymes that influence translation and ribosome function, including in mitochondria. The cobalamin biosynthesis term is less central to the core theme but may reflect broader methyltransferase activity here.","confidence":"High","size":12,"edges":8,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0030488","count":2},{"id":"GO:0019919","count":2},{"id":"GO:0070901","count":2},{"id":"GO:0009236","count":2}]},{"hash":"1086720932929668667","title":"Membrane xenobiotic and metal ion transporters","description":"These proteins are annotated with GO terms for xenobiotic transmembrane transport, sodium-dependent organic anion transport, arsenite/antimonite transport, zinc ion transport, and pyruvate transport, indicating a cluster of membrane transporters with broad substrate specificity across xenobiotics, metal ions, and metabolites.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0043251","count":2},{"id":"GO:0006849","count":2},{"id":"GO:0015699","count":2},{"id":"GO:0015700","count":2}]},{"hash":"1647411602201084061","title":"Organogenesis and neural differentiation","description":"This cluster is enriched for multicellular development, organ induction, and nervous system patterning (axon guidance, presynaptic organization), along with cell adhesion and tissue specification terms, pointing to broad organogenesis and neural development roles. A few immune-related terms are present but do not redefine the main theme. ","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:1905065","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0007157","count":6}]},{"hash":"1565061355377756410","title":"Mitochondrial Metabolism and Apoptosis Regulation","description":"Most terms point to mitochondria-anchored metabolism and apoptosis: heme and ubiquinone biosynthesis, regulation of ATP metabolism, and positive regulation of mitochondrial outer membrane permeabilization in apoptotic signaling. The single ER-to-Golgi transport term and proteasomal regulation terms are less central but may relate to broader cellular quality control, while erythrocyte differentiation echoes heme biology. Overall, the cluster seems to reflect mitochondrial energy production with apoptotic regulation.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006783","count":2},{"id":"GO:0006888","count":1},{"id":"GO:0006744","count":1},{"id":"GO:1904808","count":1},{"id":"GO:0032435","count":1}]},{"hash":"672716101538957250","title":"Neural development and cell adhesion","description":"The top GO terms cluster around cell\u2013cell adhesion (homophilic/heterophilic and general adhesion) and neural development (ventricular zone neuroblast division, nerve impulse transmission, cortex-related FGFR signaling), with additional developmental themes in mesenchyme and skeletal system formation. This suggests a cohesive focus on developmental processes where cell adhesion and neural differentiation intersect, making the label both specific and representative.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":9},{"id":"GO:0007157","count":9},{"id":"GO:0019226","count":8},{"id":"GO:0016337","count":8},{"id":"GO:0060484","count":8}]},{"hash":"203636937130593598","title":"Developmental Differentiation and Morphogenesis","description":"The top GO terms cluster around embryonic development and tissue morphogenesis across multiple lineages (mesoderm development, left-right pattern formation, cartilage and hair follicle morphogenesis, trophoblast giant cell differentiation, EMT in heart development, pancreatic cell development). There are also general gene expression processes (RNA polymerase II regulation, mRNA splicing, ribosomal export) that support development. This combination suggests a broad developmental differentiation program rather than a single pathway, hence the label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":3},{"id":"GO:0007498","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0003198","count":3}]},{"hash":"2229364135591773975","title":"Sphingolipid signaling and metabolism","description":"Dominant themes are sphingolipid-related processes: regulation of sphingolipid mediated signaling, sphingosine and sphinganine-1-phosphate metabolism. Intracellular signal transduction terms appear as a general context, but the strongest recurring GO terms cluster around lipid signaling and metabolism, supporting a label of sphingolipid signaling and metabolism. A few terms reference Wnt-related pathways and glucose-6-phosphate transport, which may reflect broader signaling roles or annotation noise.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":2},{"id":"GO:0006655","count":2},{"id":"GO:0035233","count":2},{"id":"GO:0044329","count":2},{"id":"GO:1902068","count":2}]},{"hash":"163627678231924037","title":"Lipid metabolism and inflammatory-vascular signaling","description":"The cluster includes lipid biosynthesis terms (ceramide, monounsaturated fatty acids, cholesterol esters) together with inflammatory signaling and vascular-related processes (ERK cascade regulation and endothelial cell migration), suggesting lipid-mediated signaling in inflammation and vascular remodeling. Some terms are older/obsolete (skin water loss regulation, cholesterol esterification) but the core theme points to lipid metabolism linked to inflammatory and vascular functions.","confidence":"Medium","size":11,"edges":14,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0043536","count":3},{"id":"GO:0002544","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0030539","count":2}]},{"hash":"390890748561510346","title":"Actin Cytoskeleton Remodeling and Lamellipodium Formation","description":"This cluster is dominated by actin dynamics: lamellipodium assembly/morphogenesis, actin polymerization, Arp2/3-mediated nucleation, actin cytoskeleton organization, and Rac signaling, pointing to cohesive remodeling of actin networks to drive lamellipodial protrusions and spine morphology.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":10},{"id":"GO:0060997","count":9},{"id":"GO:0030041","count":7},{"id":"GO:2000601","count":7},{"id":"GO:0030036","count":7}]},{"hash":"1775274853617190552","title":"Nutrient-Responsive Fungal Growth and Secretion","description":"The top GO terms point to a fungal morphogenesis program triggered by nutrient limitation (pseudohyphal and invasive growth in response to glucose limitation) and to activation of secretory/trafficking processes (protein exit from ER, localization to the cell surface, secretion of lysosomal enzymes). Lipid metabolism terms (cholesterol, lipoprotein, fatty acid biosynthesis) suggest accompanying metabolic remodeling. Together, these terms imply a coordinated growth form switch in response to nutrients with associated secretion and lipid handling.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007124","count":2},{"id":"GO:2000010","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0061060","count":2},{"id":"GO:0033299","count":2}]},{"hash":"1081387741040241989","title":"Neuronal Synaptic Signaling and Plasticity","description":"This cluster is dominated by terms related to neural communication and plasticity, including glutamatergic synaptic transmission, presynaptic membrane assembly, and short-term memory, pointing to a neuronal signaling role. Retinoic acid responsiveness and cell-matrix adhesion further support neural development and synapse organization. The presence of angiogenesis and complement activation terms suggests additional, broader signaling interactions with vascular and immune processes, but the core signal appears centered on neuronal synaptic function and plasticity.","confidence":"Medium","size":11,"edges":13,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":4},{"id":"GO:0007614","count":3},{"id":"GO:0035249","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0006958","count":3}]},{"hash":"212128904313561405","title":"Endothelial NO signaling and vascular regulation","description":"The cluster centers on endothelial function and nitric oxide\u2013mediated signaling, with vasodilation and endothelial proliferation highlighted. Additional terms tie into lipid handling in the vasculature (lipoprotein lipase activity, HDL remodeling) and hormonal/environmental modulation (estrogen response, xenobiotic and nutrient responses), all common in maintaining vascular homeostasis. ","confidence":"High","size":11,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051000","count":4},{"id":"GO:0001935","count":4},{"id":"GO:0051006","count":4},{"id":"GO:0042311","count":3},{"id":"GO:0050713","count":3}]},{"hash":"1015793471424928959","title":"Neuroimmune signaling and synaptic function","description":"Contains immune-response terms (LPS, GM-CSF, interferon-beta) and neural/synaptic terms (dopamine response, glutamatergic transmission, synapse assembly, corpus callosum development). Together they suggest proteins at the neuroimmune interface that modulate synaptic signaling and neural development. Confidence: Medium","confidence":"","size":11,"edges":11,"triangles":5,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":7},{"id":"GO:0097011","count":7},{"id":"GO:0050852","count":6},{"id":"GO:0022038","count":5},{"id":"GO:0043552","count":5}]},{"hash":"1872718818811221292","title":"Thiamine and Folate Biosynthesis","description":"The top GO terms emphasize thiamine biosynthesis, tetrahydrofolate metabolic process, and thiamine diphosphate biosynthesis, pointing to a shared role in producing essential cofactors for metabolism. Some other terms (embryonic development, histone modification, fungicide response) seem less connected, suggesting annotation noise or secondary links, but the dominant theme supports a biosynthetic/cofactor function.","confidence":"Medium","size":11,"edges":20,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0046653","count":4},{"id":"GO:0009228","count":4},{"id":"GO:0001701","count":3},{"id":"GO:0016575","count":3},{"id":"GO:0051572","count":3}]},{"hash":"1609771027330704540","title":"Neural crest and sensory organ development","description":"The cluster centers on vertebrate developmental processes: neural crest cell migration, commissural neuron axon guidance, otic placode development, and retina/eye morphogenesis, with supporting roles for cell-matrix adhesion and synapse maturation. While a few terms (e.g., complement activation) are less directly tied to this theme, the dominant signal points to neural crest\u2013 and sensory organ\u2013related morphogenesis.","confidence":"Medium","size":11,"edges":11,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0010513","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0071679","count":2}]},{"hash":"154784379030880279","title":"Nuclear RNA processing and ribosome biogenesis","description":"The cluster is enriched for spliceosome-mediated mRNA splicing, mRNA export, and maturation of rRNA along with ribosomal large subunit biogenesis, pointing to a cohesive role in nuclear RNA processing and ribosome assembly; a development term appears incidental.","confidence":"High","size":11,"edges":53,"triangles":148,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0006260","count":3}]},{"hash":"1014363213336663483","title":"Endocytic trafficking and signaling regulation","description":"This cluster's top GO terms center on lysosome targeting, Golgi-to-endosome transport, and endocytosis, indicating a core function in endocytic trafficking and lysosomal routing. The presence of TORC1 signaling and negative regulation of canonical Wnt signaling suggests these proteins also participate in signaling pathway regulation, potentially linking trafficking to cellular growth and developmental pathways. Overall, the dominant theme is endocytic trafficking with associated signaling control.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0006622","count":5},{"id":"GO:0006895","count":4},{"id":"GO:0006897","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0043065","count":3}]},{"hash":"1235804310600421065","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms for translation, translation initiation, preinitiation complex formation, cytosolic ribosome assembly, tRNA processing, and ribosome biogenesis, indicating a coherent role in assembling ribosomes and enabling protein synthesis; a few DNA repair/UV response terms appear but do not define the core function.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006413","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0042256","count":2},{"id":"GO:0008033","count":2}]},{"hash":"522315256532886352","title":"Actin Cytoskeleton Remodeling in Neurons","description":"This cluster centers on actin dynamics and neuronal morphology, with multiple terms about actin polymerization, cytoskeleton reorganization, and dendritic spine maintenance/morphogenesis, plus ephrin signaling that links signaling to cytoskeletal changes. Some terms about ER stress\u2013related translation, cleavage furrow formation, and neural behaviors may broaden the annotation context, but the shared theme is actin-driven remodeling of cell shape and synaptic structures.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051282","count":11},{"id":"GO:0070358","count":11},{"id":"GO:2000251","count":11},{"id":"GO:0097062","count":11},{"id":"GO:0036493","count":11}]},{"hash":"479069704626651974","title":"RNA splicing and translation regulation","description":"The proteins cluster around RNA metabolism: spliceosome-mediated mRNA splicing (regulation and positive regulation), mRNA processing/export, and translation initiation/miRNA-mediated silencing (eIF4F assembly, preinitiation complex formation, translation inhibition). This combination suggests a cohesive group coordinating RNA maturation with subsequent translation control.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":10},{"id":"GO:0000381","count":9},{"id":"GO:0048026","count":9},{"id":"GO:1900363","count":9},{"id":"GO:0031047","count":9}]},{"hash":"1981724493492854988","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":28,"triangles":35,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0090503","count":4},{"id":"GO:0035900","count":4},{"id":"GO:0006198","count":4},{"id":"GO:0072684","count":4},{"id":"GO:0070292","count":4}]},{"hash":"257191245229607260","title":"Organogenesis and differentiation signaling","description":"This cluster centers on tissue development and differentiation, with GO terms for uterus and bladder development and cardiac muscle cell differentiation, indicating a theme of organogenesis. It also includes signaling pathways (JNK cascade, TNF-mediated signaling) and regulatory protein sumoylation, suggesting modulation of development through signaling and transcriptional control. A few terms related to DNA repair and apoptosis appear, but they are less representative of the primary developmental theme.","confidence":"Medium","size":11,"edges":22,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0016925","count":2},{"id":"GO:0003257","count":2},{"id":"GO:2000727","count":2}]},{"hash":"768847147960344784","title":"Negative regulation of signaling and transcription","description":"The top GO terms cluster around inhibitory roles in signaling and transcription (NF-kappaB activity, TNF signaling, and transcriptional regulation by RNA Pol II), with related ideas like HIF-1alpha signaling and membrane trafficking. This points to a module of regulators that dampen signaling and gene expression, with a few developmental terms likely incidental.","confidence":"Medium","size":11,"edges":43,"triangles":83,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0033209","count":3},{"id":"GO:1902306","count":3},{"id":"GO:1902072","count":3},{"id":"GO:2000009","count":3}]},{"hash":"2010721052529364386","title":"Cardiac sarcomere regulation","description":"This cluster is dominated by GO terms for cardiac muscle contraction, sarcomere organization, and regulation of heart rate by epinephrine, pointing to a muscle contraction/sarcomere function theme. Additional terms fit with sarcomere regulation and vascular smooth muscle aspects, while a few outliers (spicule insertion, APC-dependent catabolic process, ubiquitination) may reflect broader cell-protein turnover or annotation noise. Overall, the cardiac muscle/sarcomere focus best explains the cluster.","confidence":"Medium","size":11,"edges":39,"triangles":73,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":4},{"id":"GO:0034609","count":4},{"id":"GO:0045214","count":4},{"id":"GO:1904706","count":4},{"id":"GO:0003065","count":4}]},{"hash":"1552142970973254737","title":"Transcription Regulation and Immune/Apoptotic Signaling","description":"The cluster features strong signals for DNA-templated transcription and negative regulation of RNA Pol II, and includes interferon signaling and apoptosis terms (death-inducing signaling complex assembly, execution phase of apoptosis) as well as thymus development. This suggests a cohesive module where transcription control interfaces with immune signaling and programmed cell death, with some additional terms (cocaine/mechanical response) possibly reflecting broader signaling roles. ","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0060340","count":2},{"id":"GO:0048148","count":2},{"id":"GO:0032729","count":2}]},{"hash":"1862052677411531784","title":"ER Stress\u2013Linked Translational Control and mRNA Decay","description":"This cluster centers on proteins involved in ER quality control and post-transcriptional regulation of mRNA, including ERAD-related pathways, mRNA deadenylation, miRNA-mediated silencing, translation initiation and reinitiation, and P-body assembly, along with localization to microtubules/centrosomes and ER-stress\u2013induced apoptotic signaling. Together, these terms suggest a cohesive role in coupling ER stress responses to control of mRNA stability and translation.","confidence":"Medium","size":11,"edges":22,"triangles":16,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0060211","count":4},{"id":"GO:0035278","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4}]},{"hash":"1184445561630861908","title":"Neuronal adhesion and synapse formation","description":"This cluster centers on neural development and synaptic organization: adherens junction assembly (cell-cell adhesion), synaptic vesicle targeting and chemical synaptic transmission (synapse function), and cerebellar development (Purkinje cell layer formation), along with protein trafficking/localization (Golgi localization, localization to cell surface) and cytoskeletal signaling (Rho) that support neural connectivity. The GO terms collectively point to how neurons establish connections, traffic components to membranes and synapses, and form cerebellar circuits.","confidence":"High","size":11,"edges":46,"triangles":120,"max_degree":10,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0045186","count":10},{"id":"GO:0051683","count":10},{"id":"GO:2000009","count":10},{"id":"GO:0007605","count":10},{"id":"GO:0035750","count":10}]},{"hash":"1414626547874313010","title":"Taste perception and neural development with immune signaling","description":"This cluster combines GO terms tied to sensory perception (bitter taste), neural development and synaptic organization, and several immune-related processes (phagocytosis, defense against bacteria, T cell costimulation) along with developmental signaling (BMP pathway regulation and organ induction). The convergence of sensory, neural development, and immune signaling terms suggests proteins that participate in broad developmental and signaling roles affecting sensory systems and immunity, hence the label.","confidence":"Medium","size":11,"edges":18,"triangles":13,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001580","count":5},{"id":"GO:0006910","count":4},{"id":"GO:0000187","count":4},{"id":"GO:0042742","count":4},{"id":"GO:0007399","count":4}]},{"hash":"1196600884114656412","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":26,"triangles":27,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0036265","count":2}]},{"hash":"159305606931512993","title":"Neuronal development and synaptic adhesion","description":"The terms cluster around nervous system development, neuron cell-cell adhesion, and synapse assembly, indicating proteins involved in neural connectivity and synaptic formation. While there are a few unrelated terms (ossification, melanin biosynthesis, LDL signaling), the dominant theme is neural development and adhesion, justifying this label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0007156","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0007158","count":4}]},{"hash":"1965061361464470481","title":"APC/C-Dependent Mitotic Proteolysis","description":"The cluster centers on cell division and mitosis, with strong representation of APC/C-dependent catabolic processes and K11-linked ubiquitination, which together point to ubiquitin-mediated proteolysis regulating mitotic progression. Other terms about histone modification and hormone receptor assembly appear secondary; overall, the proteins seem tied to controlled degradation during the mitotic cell cycle.","confidence":"High","size":11,"edges":36,"triangles":53,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0031145","count":8},{"id":"GO:2001162","count":8},{"id":"GO:0070979","count":8},{"id":"GO:0000278","count":8}]},{"hash":"1388791906969414123","title":"Immune signaling with MAPK and ubiquitin regulation","description":"This cluster is dominated by GO terms tying together immune signaling pathways (innate immunity, T cell receptor signaling, TNF signaling, nitric oxide response) with regulation of the JNK/MAPK cascade and ubiquitin-proteasome\u2013mediated protein turnover (proteasomal ubiquitin-dependent catabolic process and autoubiquitination). The presence of DNA-templated transcription suggests downstream transcriptional outputs, linking signaling to gene expression. While ephrin receptor signaling adds a broader cell\u2013signal context, the overall theme centers on immune signaling modulated by ubiquitin-dependent regulation and transcriptional responses.","confidence":"High","size":11,"edges":52,"triangles":139,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046329","count":8},{"id":"GO:0032436","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0071732","count":6},{"id":"GO:0045087","count":6}]},{"hash":"122584595555924930","title":"Integrin signaling and actin cytoskeleton remodeling","description":"The dominant terms are integrin activation and regulation, Rho GTPase signaling, and actin structures (filopodium assembly, stress fiber regulation), pointing to cytoskeletal dynamics and cell adhesion as the core function of this cluster. Ubiquitin-dependent protein catabolic process hints at turnover during remodeling, while transcription-related terms appear less central to the main theme.","confidence":"High","size":11,"edges":12,"triangles":2,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006511","count":2},{"id":"GO:0033622","count":2},{"id":"GO:0051497","count":2}]},{"hash":"986002180893567554","title":"Calcium signaling and cytoskeleton remodeling in immune and muscle cells","description":"The cluster combines terms for calcium-mediated signaling, actin cytoskeleton reorganization, ephrin receptor signaling, and immune cell proliferation (T and B cells), plus muscle satellite cell proliferation and adhesion remodeling. This suggests a shared theme of signaling pathways that regulate cytoskeletal dynamics and cell interactions in both immune and muscle progenitor contexts, justifying the label.","confidence":"Medium","size":11,"edges":52,"triangles":141,"max_degree":10,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0050850","count":11},{"id":"GO:2000251","count":11},{"id":"GO:0031532","count":11},{"id":"GO:1902728","count":11},{"id":"GO:0036493","count":11}]},{"hash":"1949105424594635548","title":"Immune Signaling and Neuromodulation","description":"The top GO terms point to immune-related processes (macrophage colony-stimulating factor stimulus, T cell receptor signaling, interferon production, neutrophil homeostasis) alongside signaling and neuromodulatory terms (dopamine metabolism, cAMP/cGMP signaling, phototransduction). This suggests a cluster enriched for signaling that links immune responses with neural/sensory modulation, rather than a single cohesive pathway, so the label reflects a broad immune-signaling with neuromodulatory cues.","confidence":"Medium","size":11,"edges":36,"triangles":59,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0036006","count":4},{"id":"GO:0042053","count":4},{"id":"GO:0055118","count":4},{"id":"GO:0033159","count":4},{"id":"GO:0019934","count":4}]},{"hash":"1158219484667338552","title":"Neural crest migration and axon guidance","description":"This cluster centers on neural development, especially neural crest cell migration and axon pathfinding. The top GO terms include semaphorin-plexin signaling and various axon guidance and projection guidance terms (sympathetic neuron, branchiomotor neuron, trigeminal nerve organization, axon extension), along with myelination and paranodal localization, all pointing to neural connectivity and nerve maturation; collagen fibril organization suggests ECM roles in this process.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0036486","count":4},{"id":"GO:1902287","count":4},{"id":"GO:0097491","count":4}]},{"hash":"763890715026339654","title":"Embryonic patterning and organogenesis","description":"The cluster's GO terms cluster around embryonic development across tissues\u2014left/right pattern formation, heart-related endocardial cushion formation, placenta-related differentiation, cartilage morphogenesis, and pancreatic endocrine development\u2014suggesting a shared theme of tissue patterning and organ formation. Some broader regulatory processes appear at lower frequency but do not dominate the theme.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4}]},{"hash":"1866380510926654121","title":"Neural development and neuronal survival signaling","description":"The top GO terms cluster around cerebral cortex and corpus callosum development, axon regeneration, and modulation of apoptotic/stress pathways (ER stress\u2013induced intrinsic apoptosis, JNK cascade), suggesting a common theme of neural development coupled with cell survival and regeneration signaling. Some terms (meiotic DSB formation, galactose-responsive transcription, cardiac proliferation) appear more divergent or pleiotropic, but do not overwhelm the neural-development-focused signals. Overall, the name reflects the dominant pattern of neural development with regulation of survival and regenerative signaling.","confidence":"Medium","size":11,"edges":14,"triangles":3,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":8},{"id":"GO:0070059","count":8},{"id":"GO:0046329","count":8},{"id":"GO:0072428","count":8},{"id":"GO:0021987","count":8}]},{"hash":"663912069716185470","title":"Immune cell ubiquitination and autophagy","description":"Top terms are dominated by ubiquitination (autoubiquitination, polyubiquitination, actin ubiquitination) and autophagy, with immune-related processes such as V(D)J recombination, B cell homeostasis, non-canonical NF-kappaB signaling, and chemokine production also prominent. This suggests a cohesive theme where ubiquitination and autophagy intersect to regulate immune signaling and B cell functions, justifying a concise label centered on these processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":11},{"id":"GO:0090073","count":11},{"id":"GO:0006914","count":11},{"id":"GO:0097039","count":11},{"id":"GO:0033151","count":11}]},{"hash":"1901179677590437664","title":"Antibacterial defense and cytolysis","description":"The top GO terms largely point to defense responses against bacteria, cytolysis, and catabolic processes of bacterial cell walls (peptidoglycan and cell wall macromolecules), suggesting proteins involved in antibacterial defense and breakdown of bacterial structures. Some terms like viral release, pain regulation, and locomotory behavior are less central but may reflect broader infection-related signaling; overall the common theme is host defense and cytolysis related to bacteria.","confidence":"Medium","size":11,"edges":15,"triangles":8,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042742","count":11},{"id":"GO:0051930","count":10},{"id":"GO:0019835","count":10},{"id":"GO:0019076","count":10},{"id":"GO:0009253","count":10}]},{"hash":"1596096087499722535","title":"Golgi-ER-Vacuole Vesicle Trafficking","description":"This cluster is dominated by GO terms for vesicle transport involving the Golgi, ER, endosomes, and vacuoles, including retrograde and anterograde routes, Golgi inheritance, and synaptic vesicle movement, indicating a core function in intracellular trafficking centered on the Golgi apparatus.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042147","count":10},{"id":"GO:0006888","count":10},{"id":"GO:0006890","count":10},{"id":"GO:0006623","count":9},{"id":"GO:0016185","count":9}]},{"hash":"768866656270119444","title":"Neural development and stress-induced apoptosis","description":"The top GO terms cluster around neural development (cerebral cortex and corpus callosum development, axon regeneration) and cellular stress/apoptosis pathways (ER stress\u2013mediated intrinsic apoptosis, JNK regulation, anoikis, DNA damage checkpoints). Together, these suggest a theme where neural development processes are linked with stress-response and apoptotic signaling.","confidence":"Medium","size":11,"edges":15,"triangles":6,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":11},{"id":"GO:0070059","count":11},{"id":"GO:0046329","count":11},{"id":"GO:0072428","count":11},{"id":"GO:0021987","count":11}]},{"hash":"280763901637310735","title":"Neural development and apoptosis regulation","description":"The top GO terms emphasize brain development (cerebral cortex and corpus callosum development, regulation of axon regeneration) along with apoptosis and stress-response processes (negative regulation of JNK cascade, intrinsic apoptotic signaling in response to ER stress, negative regulation of anoikis). This points to a coherent theme around neural development and neuron survival under stress, despite a few terms that are less directly related (meiotic DNA double-strand break formation, galactose-mediated transcription). Overall, the label reflects the dominant functions in the cluster.","confidence":"Medium","size":11,"edges":35,"triangles":47,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":11},{"id":"GO:0070059","count":11},{"id":"GO:0046329","count":11},{"id":"GO:0072428","count":11},{"id":"GO:0021987","count":11}]},{"hash":"116666213961190904","title":"Innate and Adaptive Immune Activation","description":"The terms include phagocytosis recognition and engulfment, complement activation, and innate immune response, along with antigen processing and presentation via MHC I and II, B cell receptor signaling, and B cell activation, plus antibacterial humoral response and IL-17 production. This mixture points to a cluster of proteins coordinating both innate defense (phagocytosis, complement) and adaptive responses (antigen presentation, B cell signaling). Thus the label captures cross-talk between innate immunity and adaptive antigen presentation.","confidence":"High","size":11,"edges":47,"triangles":106,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":11},{"id":"GO:0006958","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0050871","count":11},{"id":"GO:0050853","count":11}]},{"hash":"2165499378575394093","title":"Plasminogen Activation and Fibrinolysis","description":"This cluster is characterized by terms tied to extracellular proteolysis, especially plasminogen activation and fibrinolysis, including the urokinase plasminogen activator signaling pathway. While other terms touch on digestion or signal regulation, the clearest and most frequent signals point to proteolytic remodeling outside the cell, centered on the plasminogen system.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009405","count":3},{"id":"GO:0044179","count":3},{"id":"GO:1900116","count":3},{"id":"GO:0050884","count":3},{"id":"GO:0007586","count":2}]},{"hash":"1292618231356619251","title":"Unknown","description":"The top GO terms are scattered across diverse processes (cilia-related assembly, amino acid biosynthesis, SOS response, translation, inositol phosphate biosynthesis, and development), with no clear unifying function. With zero edges and no detectable connectivity, there isn\u2019t a cohesive theme linking these proteins. Therefore, label: Unknown.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044458","count":2},{"id":"GO:0019878","count":1},{"id":"GO:0006526","count":1},{"id":"GO:0009432","count":1},{"id":"GO:0018410","count":1}]},{"hash":"1766463480090282052","title":"Dopaminergic Signaling and Pain/Grooming Behaviors","description":"This cluster is dominated by neural signaling and behavior-related terms, notably dopaminergic synaptic transmission, neuropeptide signaling, and grooming behavior, with pain perception and enteric nervous system development also tying into a nervous-system theme. While a couple of terms (saliva secretion, DN2 thymocyte differentiation) seem less connected, the core pattern points to dopamine-mediated neural signaling and related behaviors.","confidence":"Medium","size":11,"edges":35,"triangles":36,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":10},{"id":"GO:0072224","count":10},{"id":"GO:0060160","count":10},{"id":"GO:0048484","count":10},{"id":"GO:2000458","count":10}]},{"hash":"146599420768461158","title":"Unknown","description":"This cluster ties together a broad mix of functions, including immune-related processes (defense response to bacterium, peptidoglycan and cell wall catabolic processes), viral processes (viral release from host cell), and more general cellular activities (regulation of sensory perception of pain, locomotory behavior, electron transport chain, and signaling). The top GO terms do not converge on a single coherent biological theme, making it unclear what common function links these proteins. Therefore Unknown.","confidence":"","size":11,"edges":9,"triangles":2,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":11},{"id":"GO:0019835","count":11},{"id":"GO:0019076","count":11},{"id":"GO:0009253","count":11},{"id":"GO:0007194","count":11}]},{"hash":"931783224512318783","title":"Neural development and synaptic signaling","description":"In this cluster, the GO terms converge on neural development and synaptic function, including neuron migration (lateral motor column), differentiation, ephrin signaling regulation, and regulation of synaptic plasticity and receptor localization at synapses, as well as chemical synaptic transmission. Additional terms related to SMAD signaling and angiogenesis reflect broader developmental contexts but can be connected to neural development pathways, supporting a cohesive theme around neural development and synaptic regulation.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090298","count":1},{"id":"GO:0035264","count":1},{"id":"GO:0090005","count":1},{"id":"GO:0007268","count":1},{"id":"GO:0035026","count":1}]},{"hash":"521914565964884982","title":"RNA Methylation and RNA Modification","description":"This cluster is dominated by RNA modification processes, including mRNA capping, rRNA and tRNA methylation, and guanine-N7 methylation, suggesting a group of RNA-modifying enzymes. Some terms such as antibiotic biosynthesis, nodulation, and tellurium ion response appear more divergent, possibly reflecting multifunctional enzymes or annotation noise.","confidence":"High","size":11,"edges":26,"triangles":24,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":9},{"id":"GO:0006370","count":9},{"id":"GO:0017000","count":9},{"id":"GO:0019919","count":8},{"id":"GO:0002098","count":8}]},{"hash":"1058257952139123468","title":"Nematode mating and reproductive signaling","description":"This cluster is dominated by GO terms related to mating and reproductive processes in nematodes (e.g., regulation of female receptivity post-mating, vulval location, response to hermaphrodite contact, male pronucleus assembly) and calcium- or kinase-driven signaling cascades (calcineurin-NFAT, JUN kinase). While some terms appear unrelated (e.g., platelet granule organization), the shared emphasis on mating behavior, receptivity, and reproductive signaling suggests a cohesive theme around nematode reproductive signaling pathways.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046008","count":3},{"id":"GO:0034608","count":3},{"id":"GO:0070884","count":3},{"id":"GO:0034606","count":3},{"id":"GO:0035039","count":3}]},{"hash":"2289398048789984854","title":"Redox homeostasis and NF-\u03baB signaling","description":"This cluster is dominated by redox/oxidative stress terms (cell redox homeostasis; removal of superoxide radicals; cellular oxidant detoxification; cellular response to hydrogen peroxide; oxidation-reduction processes), suggesting a core theme of managing cellular redox state. The presence of I-kappaB phosphorylation points to NF-\u03baB pathway involvement, indicating a link between redox balance and inflammatory signaling. A few terms related to NK cell cytotoxicity and lipoprotein biosynthesis appear but are less central to the main redox-focused theme. Overall, the cluster appears to group proteins involved in oxidative stress response and redox regulation with connections to NF-\u03baB signaling.","confidence":"High","size":11,"edges":28,"triangles":35,"max_degree":10,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0045454","count":6},{"id":"GO:0098869","count":5},{"id":"GO:0019430","count":5},{"id":"GO:0070301","count":5}]},{"hash":"548668707067745042","title":"Muscle and cytoskeleton development","description":"The cluster centers on muscle formation and cytoskeletal dynamics, with terms like larval somatic muscle development, stress fiber assembly, and negative regulation of Rho signaling. Additional terms touch on cardiac muscle differentiation and nervous system development, suggesting broader development roles, but the core theme is muscle/cytoskeleton-related processes.","confidence":"Medium","size":11,"edges":8,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016457","count":2},{"id":"GO:0043984","count":2},{"id":"GO:0007526","count":2},{"id":"GO:0030727","count":2},{"id":"GO:0043149","count":2}]},{"hash":"1842195548864440885","title":"Developmental Transcription and Morphogenesis","description":"The top GO terms center on transcription by RNA polymerase II and a set of morphogenesis-related processes (comma-shaped body morphogenesis, Malpighian tubule tip cell differentiation, floor plate development, ascending aorta morphogenesis, heart induction-related Notch signaling). While other terms like humoral immune response and senescence appear, the strongest signal is regulation of gene expression coupled with developmental tissue patterning, suggesting a cluster of proteins involved in developmental transcriptional control and morphogenesis.","confidence":"Medium","size":11,"edges":32,"triangles":43,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0072049","count":6},{"id":"GO:0061382","count":6},{"id":"GO:0072750","count":6},{"id":"GO:0090403","count":6}]},{"hash":"1801058418127894010","title":"Inflammation and mechanotransduction","description":"The terms cluster around inflammatory signaling (inflammatory response; TNF production; IL-12 production regulation) and responses to mechanical stimuli (cellular response to mechanical stimulus; response to muscle stretch), with a nod to immune differentiation and cardiac signaling (follicular dendritic cell differentiation; regulation of SA node cell action potential). This suggests a coherent theme of inflammation intertwined with mechanical cue sensing across tissues.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0006954","count":2},{"id":"GO:0002268","count":2},{"id":"GO:0032760","count":2}]},{"hash":"2056096063494279294","title":"Brain and B cell signaling","description":"The top GO terms indicate both neural and immune functions, with brain development and regulation of dopamine secretion alongside follicular B cell differentiation and positive regulation of B cell receptor signaling. Additional terms (negative regulation of Ras signaling, positive regulation of apoptotic process, ribophagy) point to shared cell-survival and autophagy pathways that can operate in diverse tissues. The recurring theme is signaling interactions between neural and humoral compartments, supported by autophagy-related processes.","confidence":"Medium","size":11,"edges":9,"triangles":7,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0046580","count":11},{"id":"GO:0071236","count":8},{"id":"GO:0001302","count":8},{"id":"GO:0043065","count":8},{"id":"GO:0034517","count":8}]},{"hash":"414109918703017157","title":"Developmental morphogenesis and organogenesis","description":"Most of the top GO terms describe morphogenesis and organ development across tissues (comma-shaped body morphogenesis; floor plate development; ascending aorta morphogenesis; Malpighian tubule tip cell differentiation; Notch signaling linked heart induction). A few terms involve immune response or cellular stress, but the dominant theme is developmental patterning and organogenesis, suggesting the cluster comprises proteins involved in developmental morphogenesis.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0072049","count":11},{"id":"GO:0061382","count":11},{"id":"GO:0072750","count":11},{"id":"GO:0090403","count":11},{"id":"GO:0006959","count":11}]},{"hash":"353602999371148647","title":"Lens and eye development","description":"The top GO terms are dominated by lens-related processes (lens fiber cell morphogenesis, differentiation, and development) as well as camera-type eye development and visual perception, indicating the proteins cluster around lens/eye formation and function. A few unrelated terms (sorocarp morphogenesis) appear as noise, but the lens/eye signals are strong and cohesive.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070309","count":11},{"id":"GO:0070306","count":11},{"id":"GO:0007601","count":11},{"id":"GO:0070307","count":11},{"id":"GO:0002009","count":11}]},{"hash":"688818090667491168","title":"Innate antiviral and immune-regulatory proteins","description":"The GO terms point to innate immune sensing and antiviral defense (RIG-I signaling, NF-kB, IL-17 pathways), along with regulation of inflammatory responses (IL-1\u03b2, MHC I biosynthesis). Some terms also reflect cellular stress responses (membrane repair, aggresome assembly) and chromatin-related regulation (histone ubiquitination) and vitamin D receptor signaling, suggesting a broader theme of immune regulation and host defense rather than a single pathway. Thus the cluster can be described as innate immune and antiviral regulatory proteins.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050713","count":1},{"id":"GO:1902187","count":1},{"id":"GO:0070562","count":1},{"id":"GO:0036353","count":1},{"id":"GO:0045345","count":1}]},{"hash":"241292761202350200","title":"Regulation of cytotoxic immune responses","description":"The terms center on modulation of cytotoxic effector functions and degranulation across CTLs, NK cells, and mast cells, including ADCC and hypersensitivity regulation, plus signaling (STAT phosphorylation), dendritic cell differentiation, and related inflammatory/wound-healing contexts. This points to a cohesive theme of controlling cytotoxic immune activity.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043318","count":9},{"id":"GO:0071639","count":9},{"id":"GO:2001200","count":9},{"id":"GO:0042523","count":9},{"id":"GO:0001805","count":9}]},{"hash":"336832269297958451","title":"Developmental Signaling and Tissue Remodeling","description":"These terms cluster around developmental morphogenesis and tissue remodeling, including lung epithelial tube branching, decidualization, and neural precursor proliferation, with regulatory signaling links (Wnt and thyroid hormone) and catabolic activity on peptides and collagen (bradykinin, neuropeptides, collagen). This suggests a cohesive theme of developmental remodeling guided by peptide metabolism and signaling regulation.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":11},{"id":"GO:0050790","count":11},{"id":"GO:0010813","count":11},{"id":"GO:0001913","count":11},{"id":"GO:0060441","count":11}]},{"hash":"2151879033578324562","title":"Sphingolipid Metabolism in Skin Differentiation","description":"The cluster is dominated by sphingolipid-related processes (ceramide catabolic; sphingosine and phytosphingosine biosynthesis) and terms tied to keratinocyte differentiation and cell adhesion. This points to lipid signaling and metabolism shaping epidermal differentiation and adhesion rather than unrelated functions. The fat cell differentiation term suggests broader lipid metabolism involvement, but the core theme centers on sphingolipid biology in skin and adhesion contexts.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:0045444","count":2},{"id":"GO:0046514","count":2},{"id":"GO:0090285","count":2},{"id":"GO:0071602","count":2}]},{"hash":"1152668941109990830","title":"Mitochondrial Metabolism and Inflammatory Signaling","description":"The proteins are enriched for mitochondrial processes (pyruvate import into mitochondria, mitochondrial ribosome assembly, acetyl-CoA related pathways) and broader metabolism (ethanol metabolism), with a subset related to inflammatory/immune signaling (response to LPS, leukotriene production) and glucose-stimulated insulin secretion. This combination points to a theme of mitochondrial energy metabolism linked to metabolic/inflammatory signaling.","confidence":"Medium","size":10,"edges":36,"triangles":64,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0061732","count":2},{"id":"GO:0035774","count":2},{"id":"GO:1902361","count":2},{"id":"GO:0006067","count":2},{"id":"GO:0061668","count":2}]},{"hash":"792228322021286239","title":"Schwann cell\u2013neuron development and neuromuscular function","description":"The cluster is dominated by terms tied to Schwann cell biology (migration/proliferation regulation), motor neuron differentiation, neurofilament cytoskeleton organization, and neuromuscular processes, suggesting a cohesive theme of Schwann cell\u2013neuron development and motor function. Supporting terms such as ceramide and collagen biosynthesis may relate to myelin and extracellular matrix roles in neural development. Overall, the proteins appear to participate in neural development and neuromuscular signaling rather than unrelated pathways.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0046513","count":2},{"id":"GO:0032964","count":2},{"id":"GO:1900148","count":2},{"id":"GO:0060052","count":2},{"id":"GO:0002238","count":2}]},{"hash":"258588541452375787","title":"Neuronal signaling and sensory perception","description":"Based on the Top Terms, several GO terms point to nervous system function: detection of light stimulus for vision, cellular response to electrical stimulus, GPCR signaling, and regulation of glutamatergic synaptic transmission, along with regulation of sensory perception of pain and locomotory behavior. These collectively suggest a cluster enriched for neuronal signaling and sensory processing. Some terms like vacuole fusion, electron transport chain, and sebaceous gland development appear unrelated, likely reflecting annotation noise or multifunctionality; however the dominant theme remains sensory/neural signaling.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042144","count":1},{"id":"GO:0018230","count":1},{"id":"GO:0048733","count":1},{"id":"GO:0022900","count":1},{"id":"GO:0050908","count":1}]},{"hash":"1621360708175951804","title":"Xenobiotic, Vitamin, and Ion Transmembrane Transport","description":"The proteins are enriched for transmembrane transport terms across xenobiotics, vitamins (ascorbate/dehydroascorbate), and ions (potassium, sodium), plus related sugar transport processes. This points to a cohesive role in moving diverse small molecules across membranes, rather than a single substrate, justifying a label centered on transmembrane transport of xenobiotics, vitamins, and ions.","confidence":"High","size":10,"edges":41,"triangles":92,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":8},{"id":"GO:0035461","count":8},{"id":"GO:0042908","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0035725","count":7}]},{"hash":"199438988681198461","title":"Dopaminergic Neuronal Signaling and Drug-Response","description":"Dominant GO terms point to neural signaling and drug-related behavior: dopaminergic synaptic transmission, behavioral response to cocaine, and response to morphine, supported by signaling pathways like ERK cascade and GTPase regulation. Other terms hint at broader neuromodulatory and inflammatory signaling, while visual perception and heart development are less central. The core theme is neuronal signaling linked to drug-induced behaviors, making this a plausible label.","confidence":"Medium","size":10,"edges":11,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0006915","count":4}]},{"hash":"1282109836224241265","title":"Antiviral Innate Immunity and Regulation","description":"Based on the top GO terms, the cluster centers on antiviral defense and the innate immune response, with supporting roles in MHC I biosynthesis, autophagy, ubiquitination, and regulatory processes (IL-1\u03b2, miRNA silencing, apoptosis). These collectively suggest a cohesive antiviral innate immune module with both effector and regulatory functions.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0050713","count":1},{"id":"GO:0045345","count":1},{"id":"GO:0051865","count":1}]},{"hash":"2251349591938561082","title":"RNA processing and transcriptional regulation","description":"This cluster centers on gene expression control across RNA processing (mRNA splicing) and transcriptional regulation (RNA Pol II) with added post-transcriptional regulation via miRNA silencing, plus hints of epigenetic regulation through histone modification terms. The combination suggests proteins that coordinate expression at both RNA and chromatin levels, making this a coherent regulatory cluster.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000637","count":3},{"id":"GO:0048755","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0000122","count":3}]},{"hash":"1224731262223696623","title":"Actin cytoskeleton remodeling and cell adhesion","description":"Enriched terms cluster around actin cytoskeleton remodeling (lamellipodium assembly, cytoskeleton reorganization), Rho GTPase signaling, and cell\u2013matrix adhesion (cell spreading, adhesion). Neural development terms (axon guidance, Purkinje layer morphogenesis) suggest a role in neural circuit formation. The shared theme is Rho-mediated cytoskeletal dynamics coupled to adhesion.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0031532","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0021692","count":2},{"id":"GO:0030032","count":2}]},{"hash":"1274727130612771281","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0001731","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0000447","count":4},{"id":"GO:0051568","count":4}]},{"hash":"1039878827271428351","title":"Post-transcriptional gene regulation","description":"This cluster centers on post-transcriptional control of gene expression, including spliceosome-mediated mRNA splicing regulation (positive and negative) and alternative splicing, plus processes related to mRNA export, stability under stress, and RNA silencing by ncRNA/miRNA pathways and translation initiation factors. These combined terms point to a cohesive theme of post-transcriptional regulation rather than a single other pathway.","confidence":"High","size":10,"edges":34,"triangles":55,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0010610","count":4},{"id":"GO:0048025","count":4},{"id":"GO:0000381","count":3}]},{"hash":"1203516446579475174","title":"Neuronal development and dendrite signaling","description":"The top GO terms point to neural development and dendrite formation, including dendrite development (GO:0016358), positive regulation of dendrite morphogenesis (GO:0050775), neuronal stem cell population maintenance (GO:0097150), and ephrin receptor signaling (GO:0048013), indicating a coherent theme of neuronal differentiation and dendritic patterning. Some terms like leaf development or adaxial/abaxial pattern specification and vitellogenesis appear as cross-species noise, but the core cluster centers on neural development processes.","confidence":"Medium","size":10,"edges":35,"triangles":60,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":2},{"id":"GO:0050775","count":2},{"id":"GO:0009955","count":2},{"id":"GO:1902213","count":2},{"id":"GO:0048366","count":2}]},{"hash":"1913092286186820550","title":"Cytoskeleton-driven cell division and polarity","description":"Proteins in this cluster are enriched for actomyosin contractile ring contraction, sarcomere organization, and mitotic cytokinesis, pointing to cytoskeletal dynamics driving cell division and shape. They also relate to organelle localization, endocytosis regulation, and establishment/maintenance of cell polarity, suggesting a cohesive function in cytoskeleton-guided cellular organization and growth. Some terms (like ascospore wall assembly) reflect specialized structural processes but do not negate the central theme. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000916","count":10},{"id":"GO:0051654","count":10},{"id":"GO:0010628","count":10},{"id":"GO:0045214","count":10},{"id":"GO:0030476","count":10}]},{"hash":"1440396942283836324","title":"Mitotic spindle checkpoint and cell division regulation","description":"The top GO terms cluster around mitosis and spindle assembly checkpoint signaling, including cell division and mitotic cell cycle regulation. Ubiquitin-dependent protein degradation aligns with proteolytic control during mitosis, while cadherin/EMT-related terms hint at coordination between adhesion and division. Overall, the theme is cohesive: mitotic checkpoint control and regulation of cell division.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1990492","count":2},{"id":"GO:0009556","count":2},{"id":"GO:2000678","count":2},{"id":"GO:0090267","count":2},{"id":"GO:0051301","count":2}]},{"hash":"41794281241944420","title":"Mitochondrial import and mitophagy regulation","description":"The top GO terms point to mitochondrial functions: protein import into the mitochondrial matrix, calcium import into the mitochondrion, regulation of mitophagy, and regulation of ROS. These together suggest a shared theme of mitochondrial protein handling and quality control. Other terms like regeneration, learning, and fear response might reflect broader roles or annotation overlap, but the core signal remains mitochondrial regulation. ","confidence":"Medium","size":10,"edges":20,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1903959","count":3},{"id":"GO:0030150","count":3},{"id":"GO:0030855","count":3},{"id":"GO:0036444","count":3},{"id":"GO:0031101","count":3}]},{"hash":"1046140199141258917","title":"Acrosome formation and Golgi vesicle trafficking","description":"This cluster is dominated by terms for acrosome assembly, spermatid nucleus elongation, and vesicle formation/trafficking from endosomes to the Golgi, pointing to a spermatogenesis-focused program where Golgi-derived vesicles contribute to acrosome formation. While nuclear processes like DNA replication and transcription appear among the terms, they seem secondary to the main vesicle-trafficking/spermatogenesis theme.","confidence":"High","size":10,"edges":21,"triangles":20,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0048015","count":3},{"id":"GO:0045899","count":2},{"id":"GO:0070676","count":2},{"id":"GO:0032968","count":2}]},{"hash":"1087185165069619417","title":"Telomere maintenance and telomeric localization","description":"Top GO terms indicate telomere protection, subtelomeric heterochromatin formation, and G-quadruplex DNA formation, with proteins localizing to chromosome telomeres. While a few terms pertain to other processes, the dominant telomere-related signals suggest a cohesive role in chromosome end protection and telomeric localization.","confidence":"High","size":10,"edges":17,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0031848","count":4},{"id":"GO:0035390","count":4},{"id":"GO:0071919","count":4},{"id":"GO:0070198","count":3},{"id":"GO:1901347","count":2}]},{"hash":"1884735627837906025","title":"Epigenetic Regulation and Developmental Signaling","description":"Top terms indicate histone modification and epigenetic regulation, along with developmental processes and signaling responses, suggesting a cluster focused on how gene expression is controlled during development and in response to signals. While some terms are diverse or deprecated, the dominant themes are chromatin modification and developmental signaling.","confidence":"Medium","size":10,"edges":25,"triangles":18,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":1},{"id":"GO:0016575","count":1},{"id":"GO:0051572","count":1},{"id":"GO:0045793","count":1},{"id":"GO:0060992","count":1}]},{"hash":"973000626103627997","title":"Chromatin organization and histone modification","description":"Proteins here are tied to nucleosome assembly, histone methylation marks (H3K4/K27), heterochromatin organization, and targeting proteins to chromatin, indicating a chromatin-regulatory role with histone modification as a core theme. ","confidence":"High","size":10,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0016584","count":9},{"id":"GO:0006334","count":9},{"id":"GO:0080182","count":9},{"id":"GO:0097298","count":9},{"id":"GO:0070828","count":9}]},{"hash":"1328379777999007849","title":"Neural development and stress-response signaling","description":"This cluster is dominated by neural development terms, including cerebral cortex development, corpus callosum development, and axon regeneration, suggesting a neural development theme. It also features stress and apoptosis-related GO terms (ER-stress\u2013induced apoptotic signaling, negative regulation of JNK cascade, anoikis regulation) and DNA damage response signals (mitotic intra-S checkpoint signaling), indicating a co-occurring cellular stress/damage response axis that can influence neural development. A few terms (meiotic DSB formation, galactose-induced transcription) appear less directly related and may reflect broader or noisy annotations. Overall, the cluster best represents neural development with linked stress-response and DNA damage signaling processes.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000811","count":10},{"id":"GO:0070059","count":10},{"id":"GO:0046329","count":10},{"id":"GO:0072428","count":10},{"id":"GO:0021987","count":10}]},{"hash":"479132588097653682","title":"Cardiac morphogenesis and electrophysiology","description":"The top GO terms cluster around heart development (outflow tract morphogenesis, left ventricular morphogenesis) and cardiac electrical activity (regulation of atrial membrane depolarization, regulation of ventricular cell action potential) with a hypertrophy/ stress-response component, suggesting a cohesive focus on heart formation and function. A few terms related to general mechanosensation or CO2 detection appear broad, but overall the theme is cardiac development and electrophysiology.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":10},{"id":"GO:0050976","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0050966","count":10},{"id":"GO:0060371","count":10}]},{"hash":"859948129694747926","title":"Endomembrane Vesicle Trafficking","description":"This cluster is dominated by GO terms tied to vesicle transport within the secretory/endomembrane system (ER to Golgi, early/late endosome moving toward lysosome, Golgi routing, Cvt pathway), plus melanosome assembly, suggesting a core role in intracellular trafficking and organelle biogenesis. The presence of a few broader terms like mitotic cell cycle is minor noise relative to the trafficking theme.","confidence":"High","size":10,"edges":21,"triangles":20,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:1902236","count":3},{"id":"GO:0000902","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0032258","count":3}]},{"hash":"1657956404035967136","title":"Embryonic Organ Morphogenesis","description":"The top GO terms point to developmental and morphogenetic processes across multiple organs (heart, limb, eye, gonads, brain, placenta, adipose), indicating a broad involvement in embryonic tissue formation rather than a single pathway. This warrants a label centered on embryonic organ development and morphogenesis.","confidence":"High","size":10,"edges":11,"triangles":8,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0035116","count":8},{"id":"GO:0008584","count":8},{"id":"GO:0003148","count":8},{"id":"GO:0048048","count":8}]},{"hash":"1402818638589269126","title":"ECM Remodeling and Fibrinolysis","description":"This cluster is dominated by extracellular matrix degradation and remodeling terms\u2014collagen and elastin catabolic processes and extracellular matrix disassembly\u2014along with fibrinolysis and vascular-related functions (endothelial barrier establishment). These collectively point to ECM turnover and tissue/vascular remodeling rather than a single specific pathway, justifying a label centered on ECM remodeling and fibrinolysis.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030574","count":6},{"id":"GO:0045944","count":5},{"id":"GO:0055123","count":5},{"id":"GO:0071333","count":5},{"id":"GO:0042730","count":5}]},{"hash":"1282098802579661493","title":"Developmental signaling and tissue remodeling","description":"The top GO terms converge on signaling pathways (notably NF-kappaB), morphogenesis and proliferation in tissues (keratinocytes, branching morphogenesis), and remodeling of vasculature and organs (blood vessel remodeling, spleen development). A few terms appear species-specific or outdated (hemolymph coagulation, mating plug formation, obsolete mannoprotein catabolic process) and do not overturn the overall developmental remodeling theme.","confidence":"Medium","size":10,"edges":29,"triangles":42,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010838","count":8},{"id":"GO:0042381","count":8},{"id":"GO:0006517","count":8},{"id":"GO:0043123","count":8},{"id":"GO:0051260","count":8}]},{"hash":"67513464283121903","title":"RNA Regulation and Membrane Trafficking","description":"This cluster includes GO terms tied to RNA metabolism (mRNA deadenylation, translation, regulatory ncRNA\u2013mediated silencing) alongside membrane/cytoskeleton processes (plasma membrane repair, vesicle docking in exocytosis, membrane addition at cytokinesis, regulation of GTPase activity, and filopodium assembly), suggesting proteins that coordinate RNA-level regulation with membrane trafficking and cytoskeletal dynamics rather than a single, narrow function.","confidence":"Medium","size":10,"edges":17,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000289","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0001778","count":2},{"id":"GO:0043087","count":2},{"id":"GO:0051489","count":2}]},{"hash":"1703727410360664313","title":"Actin-driven cell morphogenesis and endocytosis","description":"The terms cluster around actin-driven shape changes (lamellipodium morphogenesis, cleavage furrow formation), membrane trafficking (endocytic recycling, pinocytosis), and regulation of GTPase activity, with supporting lipid signaling (phosphatidic acid biosynthesis). This combination points to coordinated cytoskeletal remodeling and membrane trafficking during cell morphogenesis.","confidence":"High","size":10,"edges":17,"triangles":9,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:0001654","count":3},{"id":"GO:0000902","count":3},{"id":"GO:0036089","count":3},{"id":"GO:1990126","count":3}]},{"hash":"533271564875765716","title":"ERAD-Linked Stress-Response Proteostasis","description":"Most terms center on protein quality control via ubiquitin and SUMO pathways and ER-associated degradation (ERAD), complemented by heat and toxic-stress responses and chaperone-related refolding. A few terms touch on mitochondrial dynamics and organ identity, but the dominant theme is proteostasis under stress. Therefore ERAD-linked proteostasis under stress is a good label.","confidence":"High","size":10,"edges":33,"triangles":50,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1903071","count":4},{"id":"GO:0009408","count":4},{"id":"GO:0070389","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0048496","count":3}]},{"hash":"2250016703675027287","title":"Cell Cycle and Innate Antiviral Response","description":"The cluster shows a core theme around mitotic cell cycle and cell division, together with innate immune signaling including cellular responses to dsRNA and type I interferon, suggesting a link between cell proliferation and antiviral pathways. Some terms (e.g., gibberellin signaling, prostate development, GPCR regulation) seem less connected and may reflect annotation noise, but the dominant pattern points to cell cycle processes with innate immune responses.","confidence":"Medium","size":10,"edges":21,"triangles":12,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0006463","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0071360","count":2},{"id":"GO:0046661","count":2}]},{"hash":"2139511775302597066","title":"Neural development and cadherin-mediated adhesion","description":"The cluster prominently features terms tied to nervous system development, sensory perception of sound, and synaptic transmission, along with cadherin- and homophilic cell\u2013cell adhesion. This pattern points to a shared function in neural development and cell\u2013cell adhesion, with other development-related terms (bone, kidney, immune differentiation, pigmentation) likely reflecting broader developmental roles or peripheral associations. Overall, the strongest signal is neural development combined with adhesion.","confidence":"Medium","size":10,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":6},{"id":"GO:0048023","count":6},{"id":"GO:0007605","count":6},{"id":"GO:0007268","count":6},{"id":"GO:0007399","count":6}]},{"hash":"589893537043748776","title":"Translation Fidelity & Protein Quality Control","description":"The cluster centers on ribosome function, translational regulation, and quality control of nascent proteins (e.g., maintaining translational fidelity, ribosome disassembly, cytoplasmic translation, and misfolded protein quality control), with additional signals of cellular stress and cell cycle processes that can accompany these functions.","confidence":"Medium","size":10,"edges":24,"triangles":24,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1990145","count":4},{"id":"GO:0032790","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0033621","count":2},{"id":"GO:0007049","count":2}]},{"hash":"878745649129682997","title":"Signaling regulation of differentiation and migration","description":"The cluster\u2019s terms emphasize regulation of signaling pathways (positive regulation of canonical Wnt signaling and ERK cascade) together with processes tied to cell fate and movement (fat cell differentiation and endothelial cell migration), plus regulatory phosphorylation activities. mRNA processing appears as a general cellular function present in many proteins. This points to a theme of signaling-controlled differentiation and cell movement rather than a single metabolic pathway, so the label captures a broad, cohesive function, albeit not tightly specific. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0045444","count":2},{"id":"GO:0031532","count":2},{"id":"GO:2001275","count":2}]},{"hash":"189803403192533612","title":"Spinal motor neuron development and axon guidance","description":"Most top GO terms cluster around neural development in the spinal cord, especially motor neuron axon guidance, motor neuron cell fate specification, ventral spinal cord interneuron specification, and spinal cord neuron differentiation. While a few terms are more general (cell-matrix adhesion, miRNA-mediated silencing), the dominant signal is spinal cord motor neuron development and axon navigation, justifying this label.","confidence":"High","size":10,"edges":16,"triangles":9,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008045","count":5},{"id":"GO:0060396","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0021520","count":5},{"id":"GO:0071657","count":4}]},{"hash":"739326857179260600","title":"Neural progenitor transcription and cytoskeleton dynamics","description":"The top GO terms point to DNA-templated transcription and protein oligomerization, alongside actin filament-based movement and cytoskeleton reorganization, with a specific hint toward forebrain ventricular zone progenitor cell division. This suggests a cluster centered on transcriptional regulation coupled with cytoskeletal remodeling during neural progenitor cell proliferation and movement. While some terms are metabolic or obsolete, the dominant signal aligns on gene expression control and cytoskeletal dynamics in neural development. ","confidence":"Medium","size":10,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0051289","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0006558","count":1},{"id":"GO:0051291","count":1}]},{"hash":"1954603289851045404","title":"Neural development and visual processing","description":"The cluster is dominated by terms tied to neural and sensory biology: retinal bipolar neuron differentiation, phototransduction, substantia nigra development, long-term memory, and adenohypophysis morphogenesis\u2014all pointing to brain/eye development and function. A few terms involve calcium-regulated processes and muscle activity, which can be relevant to neuronal signaling, but the overarching theme is neural/visual system development and function. An outlier term about chitin-based cuticle development appears as noise or cross-species annotation. ","confidence":"High","size":10,"edges":13,"triangles":13,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010881","count":9},{"id":"GO:0007602","count":9},{"id":"GO:0060040","count":9},{"id":"GO:0043065","count":9},{"id":"GO:0008365","count":9}]},{"hash":"1420457852529512834","title":"Wnt signaling and actin remodeling in development","description":"The top GO terms cluster around development and signaling (Wnt signalosome assembly, axonogenesis, bone and glomerulus development) and cytoskeletal regulation (actin crosslink formation, mechanotransduction) with some kinase signaling modulation (negative regulation of protein kinase activity). This suggests a cohesive module where Wnt-driven development is linked to cytoskeletal remodeling and mechanosensitive signaling, with possible immune signaling cross-talk.","confidence":"Medium","size":10,"edges":5,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007409","count":5},{"id":"GO:0006469","count":5},{"id":"GO:0060348","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0071260","count":5}]},{"hash":"690207637884850602","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000105","count":2},{"id":"GO:0044205","count":2},{"id":"GO:0009086","count":1},{"id":"GO:0035999","count":1},{"id":"GO:0001780","count":1}]},{"hash":"86586512740178313","title":"Glycolysis and Energy Metabolism","description":"The cluster is dominated by canonical glycolysis signals (fructose 1,6-bisphosphate metabolism), along with gluconeogenesis and fructose catabolism toward glycolytic intermediates, plus supporting energy-related processes (ATP-dependent activity regulation, V-type ATPase assembly, and GTP biosynthesis). Even though some oxidation-reduction terms are obsolete, the core theme centers on carbohydrate breakdown and energy production, with likely co-regulated metabolic enzymes forming a cohesive energy metabolism module.","confidence":"High","size":10,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051289","count":6},{"id":"GO:0055114","count":4},{"id":"GO:0061621","count":3},{"id":"GO:0006116","count":3},{"id":"GO:0070072","count":3}]},{"hash":"702918584518199458","title":"Neuronal signaling and NMJ development","description":"Dominant GO terms center on nerve impulse transmission and neuromuscular junction development, with postsynaptic receptor diffusion and ion transport highlighting synaptic function. A few terms involve barrier transport and metabolic responses, which may reflect neural tissue context rather than core function. Overall, the cluster is best described as neural signaling and NMJ formation.","confidence":"Medium","size":10,"edges":9,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":4},{"id":"GO:0007528","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0061772","count":3},{"id":"GO:0016338","count":3}]},{"hash":"368147444798233651","title":"Amino Acid Transporters","description":"The cluster is dominated by GO terms for transmembrane transport and import of specific amino acids (glutamate, serine, threonine, aspartate) and neurotransmitter precursor activity (GABA biosynthesis). This points to a core function of amino acid transport across membranes, with a few outliers related to collagen or wound healing likely reflecting multifunctional proteins in the dataset. Thus, the label 'Amino Acid Transporters' best captures the main shared function.","confidence":"High","size":10,"edges":36,"triangles":84,"max_degree":8,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0055085","count":9},{"id":"GO:0051938","count":9},{"id":"GO:0009449","count":9},{"id":"GO:0070779","count":9},{"id":"GO:0032329","count":9}]},{"hash":"355043456117510946","title":"Unknown","description":"Top GO terms are highly diverse with each term represented by a single protein, spanning nuclear DNA transposition, chromatin formation, mitochondrial cristae and translation, membrane insertion and ion homeostasis, melanocyte/melanosome processes, and formaldehyde catabolism. There is no single, coherent biological theme connecting these functions, and the cluster has no edges to reinforce a shared pathway, so the cluster cannot be reliably named by a common function.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0042407","count":1},{"id":"GO:0051204","count":1},{"id":"GO:0030007","count":1}]},{"hash":"735856746639413035","title":"Death receptor\u2013mediated apoptosis cluster","description":"The top GO terms are dominated by extrinsic apoptotic signaling via death domain receptors and related pathways (including signaling without ligand and cytochrome c release regulation), indicating the proteins mainly participate in apoptosis signaling. A few other terms (muscle filament assembly, splicing, and histone modification) seem less connected and may reflect annotation noise rather than core function.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008625","count":3},{"id":"GO:0030240","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0097192","count":2},{"id":"GO:0001844","count":2}]},{"hash":"501310460341106455","title":"Neuronal adhesion and synapse assembly","description":"The top terms cluster around nervous system development, synapse assembly, and cell\u2013cell adhesion, indicating proteins involved in neural connectivity and adhesive interactions essential for synaptogenesis. Although inflammatory and signaling terms appear, the dominant theme is neuronal adhesion and synapse formation.","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007157","count":3}]},{"hash":"2191072089140869102","title":"Neural development and myelination","description":"The top GO terms point to neural lineage maturation, especially oligodendrocyte differentiation and myelination, supported by adhesion and signaling processes (cell-matrix adhesion, calcium signaling, cAMP response, and regulation of autophosphorylation). While a few terms relate to broader development (skin development, hatching behavior, sperm binding), the dominant theme is neural development and myelination. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035187","count":2},{"id":"GO:0007339","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0031953","count":2},{"id":"GO:0071320","count":2}]},{"hash":"312876817289780254","title":"Unknown","description":"The terms are highly heterogeneous, with neuronal development entries (spinal cord motor neuron fate specification, cerebral cortex development) but also diverse processes like regulatory ncRNA silencing, deglycosylation, proteolysis, ribosomal export, and DNA replication initiation. With no cohesive shared function and no edges connecting the proteins, there is no reliable, single theme to label this cluster.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021520","count":2},{"id":"GO:0045599","count":1},{"id":"GO:0021987","count":1},{"id":"GO:0016246","count":1},{"id":"GO:0006517","count":1}]},{"hash":"1189807351976002919","title":"Unknown","description":"The top GO terms include complement activation pathways (classical and lectin), peptide hormone processing, sodium regulation and blood pressure, pregnancy and embryonic development, protein autoprocessing, and even viral entry regulation. This spread of processes suggests no single cohesive function tying the cluster together, and with no network edges to reinforce a common pathway, the proteins do not align to a clear, shared biological theme. Therefore, Unknown.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":9},{"id":"GO:0003050","count":8},{"id":"GO:0035813","count":8},{"id":"GO:0001867","count":7},{"id":"GO:0016486","count":7}]},{"hash":"605061351642599530","title":"Plant Cell Wall Biosynthesis and Glycosylation","description":"The top GO terms cluster around plant cell wall construction and modification: biosynthesis of glucuronoxylan, homogalacturonan, and mucilage; plant-type secondary cell wall biogenesis; and protein O-linked glycosylation, including GalNAc- and mannose-linked forms, plus galactose metabolism and general cell wall organization. Together these point to proteins involved in synthesizing and decorating plant cell wall polysaccharides and secreted cell wall components. The skeletal muscle regeneration term seems unrelated noise. Confidence: High.","confidence":"","size":10,"edges":35,"triangles":63,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043403","count":3},{"id":"GO:0005978","count":3},{"id":"GO:0010417","count":3},{"id":"GO:0009834","count":3},{"id":"GO:0010289","count":3}]},{"hash":"569027382430848169","title":"Neural and sensory system development","description":"Proteins in this cluster show enrichment for neural and sensory development terms, including Schwann cell development, substantia nigra development, visual perception, and visual learning, pointing to a shared role in neural/sensory tissue formation and function. While there are outliers related to heart development and general signaling (phosphorylation) and cell-cycle processes, the core signal centers on neural/sensory development, justifying the label with Medium confidence.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0010800","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0014044","count":2},{"id":"GO:0007601","count":2}]},{"hash":"1731509840023437737","title":"RNA Splicing Machinery","description":"Most terms point to RNA splicing and spliceosome activity (RNA splicing; spliceosomal complex disassembly; alternative/regulated splicing via spliceosome). A minor, likely unrelated term (actin nucleation) and a plant-specific process appear as noise; overall the cluster reflects the spliceosome/RNA processing function.","confidence":"High","size":10,"edges":25,"triangles":38,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045010","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0000380","count":2},{"id":"GO:1904876","count":2},{"id":"GO:0000390","count":2}]},{"hash":"359371812189638729","title":"Neural adhesion and synapse formation","description":"This cluster shows strong representation of neural-related GO terms, especially homophilic/heterophilic cell\u2013cell adhesion, nervous system development, and positive regulation of synapse assembly, along with axon extension and sarcomere organization. Together these suggest proteins functioning in neural connectivity through adhesion and synaptogenesis. Some terms (bone ossification, spermatid development, IL-4 production, T cell costimulation) may reflect broader expression contexts, but the dominant theme points to neural adhesion and synapse formation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007157","count":5}]},{"hash":"68354899946985244","title":"Glycan biosynthesis in reproductive development","description":"The top GO terms center on carbohydrate and glycan biosynthesis (lactose, glycosphingolipids, keratan sulfate proteoglycans, protein glycosylation) and several reproductive/ developmental processes (sperm\u2013zona pellucida binding, mammary gland development, secondary sexual characteristics). This points to a theme of glycan/glycoprotein decoration and extracellular matrix assembly in reproductive tissues, with a few outliers that are less connected. ","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007339","count":9},{"id":"GO:0075015","count":9},{"id":"GO:0021680","count":9},{"id":"GO:0005989","count":9},{"id":"GO:0006486","count":9}]},{"hash":"909526932599346929","title":"Heart development and contraction regulation","description":"This cluster is dominated by heart-related terms: heart development, outflow tract morphogenesis, and regulation of cardiac muscle contraction via calcium handling, suggesting a focus on cardiac morphogenesis and function. Some terms like angiogenesis, ossification, and phototransduction appear as peripheral associations, but the core signal centers on cardiac development and contraction. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032516","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0038095","count":3}]},{"hash":"1459909347620981876","title":"RNA Pol II Transcription Regulation","description":"Reason: The top GO terms are centered on transcription by RNA polymerase II and its regulation (negative regulation of transcription by RNA Pol II, DNA-templated transcription, and related regulatory processes). A few terms are unrelated or broader (immune signaling, spermatid/sarcomere terms), which may reflect multifunctional proteins or annotation noise, but the dominant signal is transcriptional control.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0007576","count":2},{"id":"GO:0010729","count":2},{"id":"GO:0046022","count":2},{"id":"GO:0070895","count":2}]},{"hash":"1283873748432570561","title":"Neural development and axon extension","description":"The top GO terms are dominated by nervous system development, neurogenesis, and axon extension (e.g., nervous system development, neurogenesis, axon extension, trigeminal nerve development), suggesting the proteins co-function in neural growth and patterning. Immune-related terms appear but are secondary to the neural development theme, so the label emphasizes neural growth and connectivity.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071639","count":6},{"id":"GO:1905065","count":5},{"id":"GO:0048675","count":4},{"id":"GO:0021740","count":4},{"id":"GO:0001798","count":4}]},{"hash":"1297405359651456533","title":"Plasma membrane solute transporters","description":"The cluster is dominated by diverse transmembrane transport GO terms (sodium, xenobiotic, dehydroascorbic acid, arabinose, sialic acid, urate, fructose, selenite, etc.), indicating proteins that function as transporters moving various solutes across the plasma membrane. This suggests a cohesive theme of membrane transport activity rather than a single substrate. ","confidence":"High","size":9,"edges":13,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0019852","count":6},{"id":"GO:0006855","count":6},{"id":"GO:0070837","count":6},{"id":"GO:0071332","count":6}]},{"hash":"1580613640635720083","title":"Plant circadian and light-response signaling","description":"The cluster is dominated by GO terms tied to circadian rhythm, photoperiod entrainment, circadian regulation of sleep/wake, shade avoidance, and strigolactone response, all characteristic of plant photoreception and circadian clock control. Additional terms like magnetoreception and magnetism response can align with cryptochrome-mediated light sensing that influences circadian timing. Some terms (lipid storage, DNA damage signaling) are broader but do not override the main theme. Overall, this set points to plant circadian/light-response signaling.","confidence":"High","size":9,"edges":24,"triangles":23,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045475","count":4},{"id":"GO:2000323","count":4},{"id":"GO:0071000","count":4},{"id":"GO:0050958","count":4},{"id":"GO:0043153","count":4}]},{"hash":"340534425669385147","title":"ER Targeting and Translocation","description":"This cluster centers on proteins destined for the endoplasmic reticulum and their movement via SRP-dependent cotranslational targeting, post-translational targeting, and Sec-mediated transport, plus ER-to-cytosol retrograde transport. The dominant GO terms (GO:0006616, GO:0031204, GO:0043952, GO:0030970) point to ER targeting and translocation machinery, with a few ancillary translation initiation and telomere localization terms likely incidental. Overall, the theme is cohesive around ER targeting and membrane translocation.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0031204","count":3},{"id":"GO:0006616","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0030970","count":2},{"id":"GO:0006605","count":2}]},{"hash":"1028785325972712274","title":"Ear development: otolith mineralization and ion transport","description":"This cluster combines ear-related processes (otolith mineralization and vestibulocochlear nerve formation) with widespread ion transport and calcium homeostasis (Na, Ca, Zn, Cu) and related metabolism, pointing to a theme of inner-ear development and ionic balance that supports ear function.","confidence":"Medium","size":9,"edges":23,"triangles":28,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0002028","count":6},{"id":"GO:0045299","count":6},{"id":"GO:0006564","count":6},{"id":"GO:0006825","count":6},{"id":"GO:0032470","count":6}]},{"hash":"1575428414135876204","title":"GPCR Signaling in Reproduction and Metabolism","description":"The terms are dominated by GPCR pathways (adrenergic, dopamine, adenosine) and linked calcium/cAMP signaling, plus reproductive processes (acrosome reaction, oocyte maturation) and glucose/insulin response, pointing to a cluster of GPCR-mediated signaling coordinating reproductive and metabolic signals.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":1},{"id":"GO:0010353","count":1},{"id":"GO:0007204","count":1},{"id":"GO:0071880","count":1},{"id":"GO:0007191","count":1}]},{"hash":"1587740915592050033","title":"Unknown","description":"The terms are highly diverse, spanning sporulation, actin cytoskeleton reorganization, estrous cycle, keratinocyte differentiation, neutrophil clearance, glycogen biosynthesis regulation, chemotaxis, and thiazole/thiamine biosynthesis, with no single unifying function evident among the proteins.","confidence":"","size":9,"edges":24,"triangles":24,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030435","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0044849","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0097350","count":2}]},{"hash":"597671586477956034","title":"Nuclear transport and ribosome trafficking","description":"Top GO terms indicate nuclear import (NLS-bearing proteins, ribosomal proteins), export of ribosomal subunits, and nuclear pore complex assembly, with related intracellular transport processes. The cluster thus likely comprises proteins involved in nuclear transport and ribosome trafficking.","confidence":"High","size":9,"edges":16,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":6},{"id":"GO:0034501","count":5},{"id":"GO:0006610","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0035735","count":5}]},{"hash":"1065225883023131094","title":"Neuronal RNA Processing and Translation Regulation","description":"Most terms converge on post-transcriptional gene regulation in neurons, including regulation of AMPA receptor activity and short-term synaptic plasticity, as well as control of mRNA splicing via the spliceosome and translation initiation. These common themes suggest the proteins participate in RNA processing and local translation at synapses. A couple of terms about apoptosis and DNA damage are incidental and less central to this functional theme.","confidence":"High","size":9,"edges":20,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":2},{"id":"GO:0040037","count":2},{"id":"GO:0042771","count":2},{"id":"GO:2000311","count":2},{"id":"GO:0000381","count":2}]},{"hash":"343411912793966192","title":"Dendritic spine morphogenesis and postsynaptic signaling","description":"Top GO terms are dominated by neuronal synapse-related processes: dendritic spine morphogenesis, postsynaptic density assembly, and regulation of excitatory postsynaptic potentials, suggesting a cluster of proteins involved in synapse structure and signaling. Some terms indicate broader pathways (insulin signaling, endothelial barrier, ER stress responses, T cell signaling, MAPK regulation) that may reflect protein pleiotropy, but the strongest signal points to synaptic organization and function.","confidence":"Medium","size":9,"edges":32,"triangles":58,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060997","count":5},{"id":"GO:0008286","count":5},{"id":"GO:2000463","count":5},{"id":"GO:0090557","count":5},{"id":"GO:1902237","count":5}]},{"hash":"1694213086033866247","title":"Axon Guidance and Synapse Assembly","description":"The cluster\u2019s top GO terms center on neural connectivity and development: positive regulation of synapse assembly, corpus callosum development, axonal fasciculation, and related signaling like Wnt signalosome assembly. These point to roles in axon pathfinding and synapse formation, suggesting a cohesive neuronal connectivity function, though a few terms (e.g., certain developmental terms in non-neural tissues) may be noise. Confidence reflects a coherent neural theme with some outliers.","confidence":"Medium","size":9,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0022038","count":3},{"id":"GO:0048681","count":3},{"id":"GO:0007413","count":3},{"id":"GO:2000271","count":2}]},{"hash":"1741507924071140938","title":"Ubiquitin-Mediated Stress and Cell Cycle Regulation","description":"The top GO terms center on ubiquitination (ISG15 conjugation, autoubiquitination), cell division and APC-dependent catabolic processes, and ER-stress\u2013related apoptotic signaling, suggesting a theme of ubiquitin-dependent regulation of mitosis and stress responses. Some terms (neuronal development, ABA response) may be less central or species-specific noise, but the core links point to ubiquitin signaling modulating cell cycle and stress pathways.","confidence":"Medium","size":9,"edges":27,"triangles":38,"max_degree":8,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070059","count":9},{"id":"GO:0032020","count":9},{"id":"GO:1902426","count":9},{"id":"GO:0051301","count":9},{"id":"GO:0051865","count":9}]},{"hash":"1471754996553818075","title":"Developmental Regulation and Epigenetic Remodeling","description":"The terms point to developmental processes (uterus morphogenesis, tarsal gland development, foam cell differentiation) and signaling (insulin receptor signaling), together with chromatin- and protein modification activities (nucleosome disassembly, histone exchange, tubulin deacetylation). This combination suggests proteins coordinating development and transcriptional regulation via epigenetic remodeling, hence a label emphasizing both developmental regulation and epigenetic control.","confidence":"Medium","size":9,"edges":21,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035948","count":4},{"id":"GO:0010742","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0007141","count":3},{"id":"GO:0006337","count":3}]},{"hash":"146118911561769297","title":"Redox Homeostasis and Oxidative Stress Response","description":"This cluster is dominated by GO terms related to oxidative stress and redox balance (cellular response to oxidative stress, cellular oxidant detoxification, redox homeostasis, deglutathionylation). These indicate proteins involved in managing reactive oxygen species and maintaining cellular redox state. Some terms also point to transcriptional regulation and nuclear processes (negative regulation of RNA polymerase II regulatory region binding, regulation of DNA binding), suggesting redox-linked control of gene expression. Additional terms on ER protein folding and prolyl hydroxylation imply connections to proteostasis and oxidative protein processing. Overall, the shared theme is redox regulation and oxidative stress response, with supporting links to transcriptional control and ER-associated processes.","confidence":"High","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1903026","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0080058","count":6},{"id":"GO:0098869","count":6},{"id":"GO:0034599","count":6}]},{"hash":"497017071855975551","title":"Neuronal maturation and synaptic signaling (Rho\u2013ERK)","description":"Clustering centers on neuronal development and synaptic biology, including synapse assembly, axon guidance, dendritic spine development, and Rho/ERK signaling. A heart development and innate immune response terms are less representative outliers. Overall, the cluster reflects neuronal maturation and synaptic regulation with cytoskeletal signaling.","confidence":"Medium","size":9,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0010765","count":4},{"id":"GO:0061000","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0051965","count":3}]},{"hash":"876583165024898284","title":"Embryogenesis and ubiquitin-mediated proteolysis","description":"The proteins in this cluster are enriched for embryonic development terms (in utero embryonic development, gastrulation, morphogenesis, egg chamber follicle cell formation) and ubiquitin-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, histone ubiquitination). This combination points to a group involved in early development coordinated with controlled protein turnover via ubiquitination, with a few obsolete terms reflecting historical annotations but not altering the core theme.","confidence":"High","size":9,"edges":25,"triangles":33,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":5},{"id":"GO:0033209","count":5},{"id":"GO:0036353","count":5},{"id":"GO:2000011","count":5},{"id":"GO:0030713","count":5}]},{"hash":"1220235593711193405","title":"Neural Axon Guidance and Synapse Assembly","description":"This cluster is enriched for neural development terms, including cell-matrix adhesion, motor neuron axon guidance, corpus callosum development, CNS projection neuron axonogenesis, and fasciculation of motor neuron axons, as well as positive regulation of synapse assembly. A few terms relate to growth hormone signaling and telomere regulation but the dominant signal is axon pathfinding and synapse formation, indicating a cohesive role in neural connectivity.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007160","count":7},{"id":"GO:0008045","count":7},{"id":"GO:0060396","count":7},{"id":"GO:0022038","count":6},{"id":"GO:0021952","count":6}]},{"hash":"236301853471791817","title":"Neural development and cell cycle signaling","description":"The top GO terms cluster around brain development (cerebral cortex and hippocampus development), together with mitotic and DNA replication processes and morphogenesis, suggesting proteins involved in proliferating neural progenitors driving brain formation. Growth-factor related signaling (HGF stimulus) and NF-kappaB-related activity appear as broader signaling context, while a couple of immune-related terms (B cell receptor signaling, muramyl dipeptide response) likely reflect shared signaling components rather than a dedicated immune function. Overall, the theme points to neural development coupled with cell-cycle progression rather than a classic immune or neuronal signaling module.","confidence":"Medium","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007100","count":4},{"id":"GO:0000902","count":4},{"id":"GO:0021987","count":4},{"id":"GO:0007095","count":4},{"id":"GO:0006260","count":4}]},{"hash":"609460327385079687","title":"Neuronal development and synaptic function","description":"The cluster\u2019s top terms point to neural development and synaptic activity, including dendritic spine morphogenesis, glutamate secretion, vocalization behavior, cochlea morphogenesis, and morphine response, all supported by actin cytoskeleton organization. This suggests proteins coordinating neuronal development and synaptic signaling rather than non-neural processes.","confidence":"Medium","size":9,"edges":17,"triangles":20,"max_degree":5,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0090179","count":7},{"id":"GO:0090103","count":7},{"id":"GO:0006508","count":6},{"id":"GO:0045075","count":6},{"id":"GO:0060997","count":6}]},{"hash":"523142684301512043","title":"Neural development and brain formation","description":"The terms center on brain and neural development (brain development, metencephalon development, forebrain ventricular zone progenitor cell division, axon extension, neurohypophysis development) with supporting transcriptional regulation, indicating a cohesive neural development theme.","confidence":"High","size":9,"edges":27,"triangles":42,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0022037","count":4},{"id":"GO:0021869","count":3},{"id":"GO:0051098","count":3},{"id":"GO:0044708","count":3}]},{"hash":"1287062035729196310","title":"Chromatin modification and developmental transcription regulation","description":"This cluster is dominated by GO terms for histone acetylation (H3 and H4) and regulation of DNA-templated transcription, indicating chromatin-modifying proteins that influence gene expression. The presence of insect developmental terms (imaginal disc fusion, thorax closure, sensory organ precursor fate) suggests involvement in developmental transcription programs. Although some acetylation terms are marked obsolete, the core theme of histone modification governing transcription during development remains clear.","confidence":"High","size":9,"edges":30,"triangles":57,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043966","count":6},{"id":"GO:0006351","count":4},{"id":"GO:0043982","count":4},{"id":"GO:0045652","count":4},{"id":"GO:0046529","count":4}]},{"hash":"1910261924411867774","title":"Embryonic Morphogenesis Regulators","description":"The proteins are enriched for GO terms centered on morphogenesis and organ development across multiple tissues (eye field/eye formation, outflow tract development, ureteric bud branching, digit morphogenesis, osteoblast proliferation). Several terms involve regulatory control (positive/negative regulation) of developmental processes and apoptosis during embryogenesis, pointing to factors that guide organ formation. This suggests the cluster represents regulators of embryonic morphogenesis.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045578","count":9},{"id":"GO:0003151","count":9},{"id":"GO:0060898","count":9},{"id":"GO:0060561","count":9},{"id":"GO:0002052","count":9}]},{"hash":"1759195867954952005","title":"Heart and Mesoderm Development","description":"Top GO terms indicate a tight link to mesoderm-derived tissue formation and heart development (endocardial cushion morphogenesis, organ induction, mesoderm development, cardioblast differentiation, and cardiac hypertrophy regulation). While there are a few outliers related to broader developmental processes, the dominant theme is heart/mesoderm organogenesis and associated morphogenesis, so this name captures the cluster\u2019s core function.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"wound healing","top_go_terms":[{"id":"GO:0048484","count":9},{"id":"GO:1903242","count":9},{"id":"GO:0051891","count":9},{"id":"GO:0019049","count":9},{"id":"GO:0042060","count":9}]},{"hash":"1654403857852641330","title":"Neural development and axon regeneration","description":"Based on the GO terms, the cluster is enriched for neural development processes, especially cerebral cortex and corpus callosum development, along with regulation of axon regeneration. There are also terms related to neuronal survival and stress responses (negative regulation of apoptotic pathways and ER-stress\u2013related signaling), which together suggest a theme of neural development paired with maintenance/repair mechanisms. This combination points to a coherent group centered on brain development and axonal growth/regeneration rather than general cellular processes.","confidence":"Medium","size":9,"edges":7,"triangles":2,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034351","count":4},{"id":"GO:0014850","count":4},{"id":"GO:2000811","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0046329","count":3}]},{"hash":"179049828924486765","title":"Developmental transcriptional regulation across tissues","description":"This cluster centers on regulation of transcription by RNA polymerase II and several organ development terms (heart, cerebellum, eye, motor neurons, lung morphogenesis, skeletal muscle). The combination suggests genes that broadly modulate transcription during development across multiple tissues rather than a single tissue-specific pathway. The insulin receptor signaling term may reflect growth-related regulatory crosstalk.","confidence":"Medium","size":9,"edges":6,"triangles":1,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0021549","count":4},{"id":"GO:0006366","count":4},{"id":"GO:0043010","count":4}]},{"hash":"249366119548120258","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0034354","count":1},{"id":"GO:0006569","count":1},{"id":"GO:0010136","count":1},{"id":"GO:0070050","count":1}]},{"hash":"964546292851912819","title":"Ubiquitin Signaling and Autophagy Regulation","description":"Most terms center on ubiquitination types (K63, K48, linear) and protein sumoylation, together with autophagy and its regulation, including autophagy and autoubiquitination. A term about suppression of viral release by host suggests antiviral host defense linked to ubiquitin signaling and autophagy. Taken together, the cluster reflects ubiquitin-mediated signaling pathways that regulate autophagy and innate defense.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070534","count":5},{"id":"GO:0033280","count":5},{"id":"GO:0070936","count":5},{"id":"GO:1902187","count":5},{"id":"GO:0016925","count":4}]},{"hash":"1258899322377600855","title":"Meiosis and Gametogenesis","description":"Top terms are dominated by meiosis and gamete formation (meiotic processes, homologous chromosome pairing, meiotic recombination, spermatogenesis, oogenesis), indicating a germ cell development theme. While a few outliers exist (RNA modification, sebaceous differentiation, nitric oxide production), the strongest common function across the cluster is meiosis-related gamete development.","confidence":"High","size":9,"edges":15,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0010705","count":1},{"id":"GO:0007129","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0048477","count":1}]},{"hash":"48804311103356610","title":"Embryonic organ morphogenesis","description":"Top GO terms point to embryonic development across multiple tissues, including cranial skeleton morphogenesis, tooth (odontogenesis), and neurohypophysis development. Additional terms for cell-matrix adhesion and actomyosin structure organization suggest morphogenetic tissue remodeling. Together, these signals indicate a cluster of proteins involved in early organ formation and structural development.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0042475","count":3},{"id":"GO:0071657","count":2},{"id":"GO:0051098","count":2}]},{"hash":"1355425697964475233","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The top terms cluster around actin cytoskeleton organization, actomyosin structure/contractility, and cell-matrix adhesion, all pointing to actin-driven cell motility; some neuronal migration/differentiation terms also appear, reinforcing a theme of cytoskeletal dynamics guiding movement and morphogenesis.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071657","count":7},{"id":"GO:0007160","count":7},{"id":"GO:0031032","count":7},{"id":"GO:2000637","count":7},{"id":"GO:0097477","count":7}]},{"hash":"917291640230914285","title":"Embryonic Patterning and Organogenesis","description":"The top GO terms cluster around embryogenesis and patterning across multiple organs (left/right patterning, heart cushion EMT, cartilage morphogenesis, placenta/trophoblast and pancreatic development), with some general gene regulation terms; together they suggest a developmental module rather than a single pathway.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4}]},{"hash":"1418229664416001549","title":"Neural development and stress-response signaling","description":"The cluster contains brain development terms (cerebral cortex development, corpus callosum development) and neuronal repair (regulation of axon regeneration), alongside stress- and apoptosis-related pathways (ER-stress\u2013induced apoptotic signaling, JNK cascade regulation, anoikis). While there are a few terms less tied to neural context (angiogenesis, meiotic DSB formation), the neural development and survival/regulation themes dominate, suggesting a group of proteins involved in brain development and cellular stress responses.","confidence":"Medium","size":9,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045766","count":4},{"id":"GO:2000811","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0046329","count":3},{"id":"GO:0072428","count":3}]},{"hash":"2242250464415252124","title":"Neuronal synaptic vesicle cycling and signaling","description":"This cluster's terms are dominated by neuronal synaptic processes: vesicle exocytosis/endocytosis regulation and excitatory postsynaptic potential, with substantia nigra development pointing to dopaminergic synapses. Cadmium/xenobiotic responses may reflect neuronal stress responses. Some mitotic cell cycle terms appear unrelated, likely noise. Overall, the theme is neuronal synaptic function.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0021762","count":2},{"id":"GO:0035690","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0060079","count":2}]},{"hash":"644739815921108825","title":"Developmental signaling and ECM organization","description":"The cluster's top terms show signaling pathways (phosphatidylinositol-mediated signaling, response to cAMP, nitric-oxide synthase regulation, and negative regulation of protein kinase activity) together with extracellular matrix organization and skeletal development (bone and limb development). This points to a cohesive role in developmental signaling that drives ECM remodeling and patterning in bone/limb formation, with some ancillary cytoskeletal or ion-regulatory aspects. ","confidence":"Medium","size":9,"edges":9,"triangles":5,"max_degree":4,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0048015","count":5},{"id":"GO:0051000","count":5},{"id":"GO:1902896","count":5},{"id":"GO:0090281","count":5},{"id":"GO:0051591","count":5}]},{"hash":"1759171964595498608","title":"Glycoprotein Processing and ERAD Trafficking","description":"This cluster is dominated by terms related to glycosylation and ER-associated degradation (ERAD), including protein glycosylation, mannose trimming in the ERAD pathway, and positive regulation of retrograde transport from the ER to the cytosol, plus endocytosis-related trafficking. A couple of plant-specific cell wall biosynthesis terms appear, which may reflect broader carbohydrate-processing annotations, but the core signal ties to glycoprotein maturation and ER-associated trafficking. Confidence: High","confidence":"","size":9,"edges":15,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:1904382","count":2},{"id":"GO:0006898","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0009834","count":2}]},{"hash":"1478490003427259755","title":"Steroid Biosynthesis and Metabolism","description":"This cluster is dominated by GO terms related to the biosynthesis and metabolism of steroid compounds across diverse species (ecdysone, aldosterone, brassinosteroids, bile acids) and the omega-hydroxylase P450 pathway, all pointing to a shared theme of steroid hormone production and modification via cytochrome P450 enzymes. Developmental and stress-related terms may reflect downstream roles or ancillary connections but do not override the steroid-centric signal.","confidence":"High","size":9,"edges":6,"triangles":4,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006697","count":5},{"id":"GO:0097267","count":5},{"id":"GO:0032342","count":5},{"id":"GO:0071615","count":5},{"id":"GO:0006699","count":5}]},{"hash":"1664413023834590473","title":"Developmental organogenesis and vascular regulation","description":"The top GO terms cluster around organ development and morphogenesis (pancreas morphogenesis, digestive system development, midbrain development, post-embryonic development, multicellular organism growth) with vascular-related processes (blood coagulation, regulation of arterial blood pressure by ANP, smooth muscle cell-matrix adhesion) and transcriptional regulation. This points to proteins involved in tissue development and vascular remodeling, rather than a single metabolic or immune pathway. A secondary signal of lipopolysaccharide response is present but not central to the main theme.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":9},{"id":"GO:0061113","count":8},{"id":"GO:0009791","count":8},{"id":"GO:0035264","count":8},{"id":"GO:0045944","count":8}]},{"hash":"1137217784585223229","title":"Unknown","description":"The GO terms are highly diverse, including DNA repair, fat cell differentiation, proteoglycan biosynthesis, sulfation, and several metabolic processes, with no single cohesive function emerging to tie the proteins together. Although sulfation and proteoglycan biosynthesis appear, the overall annotations are too heterogeneous to define a clear, representative cluster function.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":1},{"id":"GO:0045600","count":1},{"id":"GO:0030210","count":1},{"id":"GO:0006805","count":1},{"id":"GO:0006477","count":1}]},{"hash":"373704362928562126","title":"Lipid Metabolism and Adipogenesis","description":"The GO terms show a strong signal for lipid handling and adipogenic processes: triglyceride homeostasis, fat cell differentiation, triglyceride regulation, and LDL particle clearance, with some insulin/glucose-associated regulation terms. While there are additional development-related terms (pupariation, cartilage development, keratinocyte migration) that may reflect cross-species annotations or pleiotropy, the core theme across the cluster is lipid metabolism tied to cellular differentiation. Confidence is Medium.","confidence":"","size":9,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051546","count":2},{"id":"GO:0045842","count":2},{"id":"GO:0045444","count":1},{"id":"GO:0010988","count":1},{"id":"GO:0003417","count":1}]},{"hash":"2140703722802276409","title":"Bacterial Secretion and Motility Machinery","description":"The top GO terms highlight protein secretion via the Type III secretion system, bacterial-type flagellum assembly, and proton motive force\u2013driven ATP synthesis, pointing to a cluster centered on bacterial secretion systems and motility/energy machinery; other terms may reflect broader cellular processes but do not override this core theme. ","confidence":"Medium","size":9,"edges":20,"triangles":17,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006933","count":2},{"id":"GO:0030254","count":2},{"id":"GO:0007035","count":2},{"id":"GO:0001525","count":2},{"id":"GO:1902906","count":2}]},{"hash":"334857154082019952","title":"Developmental Differentiation with Signaling Inhibition","description":"The proteins are tied to multiple developmental processes (CNS development, heart formation, skeletal muscle differentiation) and repeatedly linked to negative regulation of major signaling pathways (BMP, Wnt, activin, PI3K-AKT), indicating a module that coordinates tissue differentiation by dampening growth signal transduction.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":5},{"id":"GO:1905456","count":4},{"id":"GO:0035914","count":4},{"id":"GO:0060914","count":4},{"id":"GO:0070197","count":4}]},{"hash":"1764551362455418586","title":"Post-transcriptional RNA processing and translation control","description":"The cluster shows strong enrichment for regulation of mRNA splicing (via spliceosome), mRNA stability under stress, mRNA export, and miRNA-mediated translation inhibition, all hallmark processes of post-transcriptional gene regulation. This suggests a cohesive group of proteins involved in coordinating RNA processing and subsequent translation control rather than purely transcriptional events.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0000381","count":8},{"id":"GO:0048026","count":8},{"id":"GO:1900363","count":8},{"id":"GO:0031047","count":8}]},{"hash":"921616049625342990","title":"Wnt-Driven Development and Morphogenesis","description":"The GO terms cluster around developmental processes and morphogenesis, anchored by the Wnt signaling pathway, which is indicated as the top signal. Pancreas morphogenesis, midbrain development, digestive system development, and post-embryonic development point to broad organogenesis and growth, while associations with transcription regulation and cell-matrix adhesion reflect coordinated gene expression and tissue organization during development. Overall, the unifying theme is development with Wnt signaling guiding morphogenetic growth.","confidence":"High","size":9,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0030574","count":3},{"id":"GO:0061113","count":2},{"id":"GO:0009791","count":2},{"id":"GO:0035264","count":2}]},{"hash":"823387416607893591","title":"Unknown","description":"The Top Terms span plant hormone signaling, antibiotic/stress responses, aging, apoptosis, ribophagy, neurotransmitter regulation, brain development, and B cell immune signaling, with no clear single function or pathway linking the proteins. Hence no cohesive theme; label as Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0009738","count":5},{"id":"GO:0071236","count":4},{"id":"GO:0001302","count":4},{"id":"GO:0043065","count":4},{"id":"GO:0034517","count":4}]},{"hash":"546977825286219297","title":"TCA Cycle and Acetyl-CoA\u2013Driven Lipid Biosynthesis","description":"Most of the top GO terms point to central carbon metabolism converging on acetyl-CoA production (pyruvate to acetyl-CoA, 2-oxoglutarate metabolism, leucine/lysine catabolism feeding into acetyl-CoA, malonyl-CoA biosynthesis) and subsequent fatty acid biosynthesis. This suggests a functional cluster centered on energy generation and lipid synthesis, with a few outlier terms (e.g., sodium transport) that are less representative. ","confidence":"Medium","size":9,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0042759","count":4},{"id":"GO:0006552","count":4},{"id":"GO:0043617","count":4},{"id":"GO:2001295","count":4}]},{"hash":"18031956964382808","title":"Signaling and Migration Cues in Cells","description":"The proteins map to a mix of signaling pathways (Wnt signaling, GPCR-related activity), trafficking and uptake processes (pinocytosis), cell movement (cell migration, electrical coupling), differentiation (fat cell differentiation), and stress/immune responses (heat response, nociception, myeloid apoptosis), suggesting a broad theme of cellular signaling influencing movement and differentiation rather than a single precise function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":7},{"id":"GO:0016477","count":7},{"id":"GO:0007205","count":7},{"id":"GO:0048549","count":7},{"id":"GO:0016055","count":7}]},{"hash":"1544305198742044918","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032973","count":6},{"id":"GO:1990034","count":6},{"id":"GO:1990569","count":4},{"id":"GO:0036085","count":3},{"id":"GO:0015786","count":3}]},{"hash":"2129245616332097523","title":"Tissue development and differentiation","description":"Based on the GO terms, the cluster is enriched for differentiation and development across multiple tissues and organs (chondrocyte and keratinocyte differentiation, adrenal gland and gonad development, ureteric bud morphogenesis, labyrinthine vessel development). Some terms relate to growth regulation and cytoskeletal organization, which can accompany morphogenesis. Overall, the common theme is tissue/organ development and differentiation rather than a single pathway.","confidence":"High","size":9,"edges":16,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051496","count":3},{"id":"GO:0002062","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0060675","count":3},{"id":"GO:0060716","count":3}]},{"hash":"1496662891446267544","title":"Immune activation and leukocyte recruitment","description":"GO terms indicate both adaptive immune activation (T cell costimulation, immature B cell differentiation, Fc receptor signaling) and innate leukocyte recruitment (neutrophil extravasation, chemokine production, monocyte chemotaxis). Regulation of MyD88-TLR signaling also points to immune signaling control. A couple terms (FGFR-related orbitofrontal cortex development) are less directly related, but the dominant pattern is immune activation and leukocyte trafficking.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031295","count":5},{"id":"GO:0001759","count":5},{"id":"GO:0002327","count":5},{"id":"GO:0072672","count":5},{"id":"GO:0034125","count":5}]},{"hash":"1446258487340943315","title":"BMP signaling and immune/vascular regulation","description":"The top GO terms cluster around developmental signaling (BMP signaling) plus immune and vascular/nodal regulatory processes (negative regulation of T cell activation, TNF signaling, NF-kB regulation, endothelial proliferation, intestinal stem cell homeostasis). While there are some less cohesive items (DNA transposition), the strongest shared theme is signaling pathways that govern tissue development and immune-vascular homeostasis. ","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008101","count":2},{"id":"GO:0070236","count":2},{"id":"GO:0036335","count":2},{"id":"GO:0048642","count":2},{"id":"GO:0001935","count":1}]},{"hash":"1174014301988115794","title":"Multi-tissue development","description":"These terms point to developmental and organogenesis processes across many tissues (embryonic development, eye and heart morphogenesis, ovarian follicle growth, prostate gland differentiation). There isn't a single tissue-specific function, so a label like multi-tissue development captures the shared theme of broad developmental programming represented in this cluster.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060528","count":8},{"id":"GO:0055010","count":8},{"id":"GO:0001701","count":8},{"id":"GO:0001547","count":8},{"id":"GO:0043010","count":8}]},{"hash":"1516828464072428743","title":"Neural development and behavior regulation","description":"The top GO terms are dominated by nervous system\u2013related processes (enteric nervous system development, astrocyte chemotaxis, dopamine receptor signaling regulation, pain perception, grooming and fear-related behaviors). There are also neuroendocrine connections (regulation of insulin secretion) and autonomic/exocrine outputs (saliva secretion), suggesting a coherent theme around neural development and modulation of neural signaling and behavior. Therefore, this label captures the cluster\u2019s core function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050796","count":6},{"id":"GO:0008284","count":6},{"id":"GO:0001662","count":6},{"id":"GO:0046541","count":5},{"id":"GO:0072224","count":5}]},{"hash":"705313886890031810","title":"Neuronal axon guidance and synapse formation","description":"The cluster is enriched for neuronal development processes: axon fasciculation and projection neuron axonogenesis, ephrin signaling, dendritic spine morphogenesis, and trans-synaptic signaling related to synapse assembly. While a thyroid-related term appears, the dominant theme centers on neural connectivity and synapse formation, justifying this label.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071300","count":4},{"id":"GO:0097156","count":4},{"id":"GO:0021952","count":4},{"id":"GO:0097155","count":4},{"id":"GO:0048013","count":4}]},{"hash":"710233468454290756","title":"Vascular development and coagulation","description":"The proteins are enriched for terms tied to blood vessel biology and coagulation\u2014blood coagulation, complement activation via the lectin pathway, endothelial cell chemotaxis, smooth muscle migration, and coronary artery morphogenesis\u2014points to vascular formation/remodeling and associated immune/coagulation processes. Some unrelated terms exist (e.g., certain axis specification or fluoride response), but the dominant theme is vascular development and coagulation.","confidence":"High","size":8,"edges":10,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0014909","count":3},{"id":"GO:0035767","count":3},{"id":"GO:0060982","count":3}]},{"hash":"2048380695762504607","title":"Eye development and photoreceptor differentiation","description":"Primarily enriched for eye development and photoreceptor differentiation, with involvement in retinal vasculature, pigment cell trafficking (melanosomes/lysosomes), and Notch/integrin signaling guiding retinal cell fate and adhesion.","confidence":"High","size":8,"edges":16,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0045747","count":6},{"id":"GO:0061298","count":6},{"id":"GO:2000145","count":6},{"id":"GO:0090528","count":6}]},{"hash":"1306614439278630135","title":"Growth-factor signaling and xenobiotic stress responses","description":"The top GO terms cluster around cellular responses to various stimuli (growth factors, insulin, xenobiotics, toxic substances, vitamins) and NF-kappaB\u2013related signaling, implying a theme of stimulus-responsive signaling rather than a single pathway. The ureteric bud development term adds a developmental signaling context but does not override the overarching stimulus-response pattern.","confidence":"Medium","size":8,"edges":25,"triangles":41,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":4},{"id":"GO:0001657","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0032868","count":4},{"id":"GO:0080184","count":4}]},{"hash":"2273468392366962557","title":"Bacterial cell wall biosynthesis and division","description":"The terms are dominated by peptidoglycan and lipoteichoic acid biosynthesis, plus cell wall organization and cell cycle/division, pointing to a cohesive theme of bacterial cell envelope biogenesis and division; some et al. terms (lignin, flavonoid, biphenyl, antibiotic biosynthesis) are less consistent with this core.","confidence":"High","size":8,"edges":12,"triangles":10,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009252","count":4},{"id":"GO:0070395","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0009808","count":4},{"id":"GO:0007049","count":4}]},{"hash":"1441906266605660127","title":"NF-kappaB\u2013driven inflammation and development","description":"The terms cluster NF-kappaB\u2013regulated inflammatory response with developmental processes such as blood vessel and brain development, plus growth signals (cell growth, fibroblast proliferation) and lipid signaling (lipid phosphorylation, sphingoid metabolism). This suggests a cohesive module where NF-kappaB\u2013mediated inflammation intersects vascular/neuronal development and growth regulation.","confidence":"High","size":8,"edges":8,"triangles":3,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0001568","count":3},{"id":"GO:0030307","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0006954","count":3}]},{"hash":"127910066643784937","title":"Inflammation-Linked Coagulation and ECM Adhesion","description":"This label captures the cluster's signal toward inflammation and vascular processes: interleukin-1 response indicating inflammation; coagulation/fibrinolysis and the common coagulation pathway terms pointing to coagulation activity; and cell-matrix adhesion plus heparin proteoglycan biosynthesis reflecting extracellular matrix interactions. Secretory/exocytosis terms further support active protein secretion in these pathways.","confidence":"High","size":8,"edges":10,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050714","count":5},{"id":"GO:0050928","count":4},{"id":"GO:0045907","count":4},{"id":"GO:0071347","count":4},{"id":"GO:0007160","count":4}]},{"hash":"552450129473382617","title":"Biosynthesis of antibiotics, pigments, and vitamins","description":"These proteins are linked to a variety of biosynthetic processes for antibiotics, pigments like melanin, vitamins and cofactors (retinol, retinal, phylloquinone, tetrahydrobiopterin) and steroid/glucocorticoid biosynthesis, indicating a cluster centered on diverse metabolite biosynthesis rather than a single pathway.","confidence":"Medium","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":7},{"id":"GO:0055114","count":7},{"id":"GO:0042574","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0042572","count":7}]},{"hash":"1513286412469545002","title":"Sterol and lipid biosynthesis","description":"This cluster shows strong representation of sterol biosynthetic processes (ergosterol, cholesterol via lathosterol), fatty acid and ether lipid metabolism, and related lipid pathways. The presence of sebaceous gland differentiation and CNS myelin maintenance terms also aligns with lipid-rich tissues and membrane lipids. Overall, the dominant theme is lipid biosynthesis and sterol metabolism.","confidence":"High","size":8,"edges":10,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0080064","count":3},{"id":"GO:0001949","count":3},{"id":"GO:0080065","count":3},{"id":"GO:0035754","count":3},{"id":"GO:0006696","count":3}]},{"hash":"940055996944811371","title":"Actin Dynamics and Cell Motility","description":"This cluster is dominated by terms related to actin cytoskeleton remodeling and movement, including actin polymerization-dependent cell motility, actin cytoskeleton reorganization, cleavage furrow formation, and dendritic spine maintenance, with ephrin signaling also tying to cytoskeletal changes. While a few terms touch on broader cellular processes (ER stress\u2013related translation, B cell differentiation), the shared function centers on actin-driven motility and structural remodeling during cell division and signaling.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":2},{"id":"GO:0051282","count":2},{"id":"GO:0070358","count":2},{"id":"GO:2000251","count":2},{"id":"GO:0097062","count":2}]},{"hash":"803481051698966936","title":"Secretory vesicle trafficking and Golgi transport","description":"These GO terms collectively describe movement of vesicles through the secretory pathway, including ER-to-Golgi (anterograde) and Golgi-to-ER (retrograde) transport, Golgi localization/inheritance, and vesicle trafficking to endosomes/vacuoles; synaptic vesicle budding and regulation of endocytosis emphasize vesicle formation and recycling. The cluster appears to center on intracellular vesicle trafficking and Golgi dynamics, representing a cohesive module of secretory pathway transport.","confidence":"High","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035646","count":5},{"id":"GO:0048490","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0006890","count":5},{"id":"GO:0006886","count":5}]},{"hash":"455025233053902668","title":"GTPase Regulation of Cell Migration and Vascular Permeability","description":"The top GO terms point to regulation of GTPase activity and Rho signaling, which govern cytoskeletal dynamics and cell movement. Several terms relate to vascular processes (regulation of vascular permeability, negative regulation of cell migration in sprouting angiogenesis, extravasation), and others to intracellular trafficking (Golgi localization, endocytic recycling). While a B cell differentiation term appears, the dominant pattern is signaling and trafficking that control cell motility and vascular barrier function, making this a cohesive cluster around GTPase-regulated migration and vascular dynamics.","confidence":"Medium","size":8,"edges":15,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051301","count":2},{"id":"GO:1904425","count":2},{"id":"GO:0051683","count":2},{"id":"GO:0035024","count":2}]},{"hash":"933699581985789192","title":"Diverse tissue differentiation","description":"The GO terms center on differentiation events across multiple tissues (cardiac muscle, adipocytes, macrophage foam cells, type I pneumocytes, ureteric bud, and brain structures), plus general transcriptional regulation and apoptosis modulation. This suggests a cluster representing broad differentiation programs across diverse tissues rather than a single unified pathway, hence a label capturing \u201cdiverse tissue differentiation.\u201d","confidence":"Medium","size":8,"edges":22,"triangles":26,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060038","count":4},{"id":"GO:0045444","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0043066","count":3},{"id":"GO:0010742","count":3}]},{"hash":"1517657688487786141","title":"Spermatogenesis and chromatin remodeling","description":"The cluster's top GO terms center on male meiosis I, seminiferous tubule development, and histone acetylation (H3, H2A, H4-K12), pointing to testis-specific germ cell development and chromatin remodeling. Additional terms on apoptotic regulation and chromatin state (e.g., heterochromatin formation) further support a theme of coordinated meiosis with chromatin modification and cell fate control in spermatogenesis.","confidence":"High","size":8,"edges":22,"triangles":29,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1901097","count":3},{"id":"GO:0007141","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0043968","count":3},{"id":"GO:0072520","count":3}]},{"hash":"236564178643954430","title":"Immune signaling and stress responses","description":"Top GO terms indicate strong representation of immune and stress-related processes: response to antibiotic, response to hypoxia, cellular response to transforming growth factor beta stimulus, positive regulation of interleukin-1 beta production, regulation of B cell differentiation, wound healing, and response to xenobiotic stimulus. This pattern suggests the proteins are involved in inflammation, immune regulation, and adaptation to environmental stress. Some terms like polar nucleus fusion and nurse cell apoptotic process are more developmental, but the core theme centers on immune signaling and stress responses.","confidence":"Medium","size":8,"edges":17,"triangles":15,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0001666","count":3},{"id":"GO:0010197","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0050718","count":2}]},{"hash":"854392281126345227","title":"Ribosome biogenesis and RNA modification","description":"The cluster is enriched for ribosome-related processes (translation and ribosome biogenesis) and RNA processing/modification (snoRNP assembly, pseudouridine synthesis in rRNA/snRNA, and RNase MRP-dependent decay). These terms together point to a coordinated set of proteins involved in ribosome assembly and RNA maturation, with a few signaling-related terms present but not defining. ","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0046330","count":1},{"id":"GO:1905267","count":1},{"id":"GO:0000492","count":1}]},{"hash":"944451307830215221","title":"RNA processing and ribosome biogenesis","description":"The top GO terms cluster around RNA processing and protein synthesis: formation of translation preinitiation complex, translation reinitiation, mRNA splicing via spliceosome, and ribosome biogenesis. These together reflect core mRNA processing and ribosome assembly functions. The other terms seem less related (developmental, stress signaling), likely representing broader annotations rather than the cluster\u2019s primary role. ","confidence":"High","size":8,"edges":21,"triangles":27,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0016575","count":1}]},{"hash":"205324507802498492","title":"Translation initiation and ribosome biogenesis","description":"The top terms point to protein synthesis machinery: translation preinitiation, translation reinitiation, and ribosome biogenesis, with a note of protein homooligomerization reflecting complex assembly. Peripheral terms relate to development or signaling, but the core signal centers on translation apparatus and ribosome assembly. ","confidence":"Medium","size":8,"edges":10,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007200","count":3},{"id":"GO:0008283","count":3}]},{"hash":"315511458028587416","title":"Retroviral life cycle","description":"The top GO terms cluster around core steps of viral infection and replication: entry into host cells, uncoating, reverse transcription (RNA-templated DNA synthesis), and proviral latency, with related protein folding and secretion processes that assist viral protein maturation and trafficking. Though some terms touch on host immune processes (e.g., leukocyte migration), the strongest signal is retroviral entry, replication, and latency.","confidence":"Medium","size":8,"edges":22,"triangles":28,"max_degree":7,"top_function":"protein folding","top_go_terms":[{"id":"GO:0050900","count":3},{"id":"GO:0006457","count":3},{"id":"GO:0030260","count":3},{"id":"GO:0010849","count":3},{"id":"GO:0000413","count":3}]},{"hash":"2181978792289878578","title":"Unknown","description":"The top GO terms span diverse areas (metabolism, behavior, signaling, ion transport, cell organization, and bone remodeling) with no clear common function. Several terms are obsolete or context-specific, making a cohesive, specific label unreliable.","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0019634","count":7},{"id":"GO:0071625","count":7},{"id":"GO:0071847","count":7},{"id":"GO:1903760","count":7},{"id":"GO:2000821","count":7}]},{"hash":"534432688607211646","title":"Immune-angiogenesis and coagulation signaling","description":"This cluster combines immune-related processes (complement activation, adaptive immune response) with vascular remodeling and coagulation-related functions (angiogenesis, endothelial cell migration, fibrinolysis) and signaling (ERK cascade). The co-occurrence of immune activation with angiogenic and coagulation-related terms suggests a cohesive module centered on inflammation-driven vascular remodeling and coagulation regulation, with possible metabolic signaling (leptin response) contributing to cross-talk. ","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0042730","count":3},{"id":"GO:0050714","count":3},{"id":"GO:0044320","count":3},{"id":"GO:0043536","count":3}]},{"hash":"1577079080695685061","title":"Gene Expression Regulation and Plant Development","description":"The cluster\u2019s top GO terms center on transcription initiation, RNA-templated transcription, and regulation of translational initiation, indicating a core theme of gene expression control. The presence of plant-development related terms (root meristem growth and auxin transport regulation) suggests a developmental context, while the centrosome-associated and telomerase-related terms point to broader nuclear/cell-cycle roles. Overall, the data best support a label around gene expression regulation with plant developmental ties.","confidence":"Medium","size":8,"edges":16,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":3},{"id":"GO:0045948","count":2},{"id":"GO:0001172","count":2},{"id":"GO:1905793","count":1},{"id":"GO:1900037","count":1}]},{"hash":"1928251833892787290","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034473","count":3},{"id":"GO:0034476","count":3},{"id":"GO:0000958","count":3},{"id":"GO:0045006","count":3},{"id":"GO:0071038","count":3}]},{"hash":"1365089767264205468","title":"Angiogenesis and vascular development regulation","description":"This cluster\u2019s GO terms cluster around blood vessel formation and vascular signaling, including retina vasculature morphogenesis, endothelial cell chemotaxis, prostaglandin biosynthesis, and estradiol response, suggesting a cohesive role in angiogenesis and hormone-modulated vascular function. Supporting terms related to growth and survival regulation may reflect broader developmental context, but the vascular/hormonal theme is the strongest through-line.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0061299","count":3},{"id":"GO:0001516","count":3},{"id":"GO:0071672","count":3}]},{"hash":"1120858804922676974","title":"Neddylation Regulation and Protein Turnover","description":"The cluster centers on protein modification by NEDD8 (neddylation) with both positive and negative regulatory terms, and associated ubiquitin-protein transferase activity and general protein catabolic processes. While there are some stress-response terms (UV-C, gamma radiation, mechanical stimulus) and a dopaminergic neuron differentiation term present, the dominant signal is neddylation regulation and ubiquitin-related protein turnover, suggesting a functional module around post-translational modification and degradation.","confidence":"High","size":8,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:2000436","count":2},{"id":"GO:0010332","count":2},{"id":"GO:2000435","count":2},{"id":"GO:0044254","count":2}]},{"hash":"957367182850411576","title":"Ubiquitin-Dependent Degradation and NF-kB Signaling","description":"These proteins cluster around ubiquitin-mediated processes (autoubiquitination, ERAD-related degradation, polyubiquitination) and autophagy, with immune signaling connections (non-canonical NF-kappaB signaling, B cell homeostasis, V(D)J recombination, chemokine production). The pattern points to a functional group coordinating protein turnover via ubiquitin pathways and modulating NF-kB\u2013driven immune responses, especially in lymphocytes.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":8},{"id":"GO:0030433","count":7},{"id":"GO:0042787","count":7},{"id":"GO:0090073","count":6},{"id":"GO:0006914","count":6}]},{"hash":"1448322167382192841","title":"Protein Quality Control and Stress Response","description":"The top GO terms cluster around proteostasis-related processes: protein refolding, detection of misfolded proteins, response to heat, and regulation of oxidative stress, with related terms involving mitochondrial protein import and general protein translocation. This suggests a cohesive theme of maintaining protein homeostasis under stress. Some terms like sperm binding or telomerase RNA localization may be incidental annotations, but the dominant pattern supports a proteostasis/stress-response function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007339","count":8},{"id":"GO:0009408","count":8},{"id":"GO:0002236","count":8},{"id":"GO:1903427","count":8},{"id":"GO:0044053","count":8}]},{"hash":"778025602413589512","title":"Embryonic neural and skeletal development","description":"These proteins show GO terms spanning neural development (myelination, regulation of synapse structure or activity), skeletal development (forelimb and digit morphogenesis, chondrocyte differentiation), and related embryonic processes, plus ER organization and basic metabolism. The common thread is broad embryonic development across multiple tissues, rather than a single cohesive pathway, which fits a high-level developmental theme. The absence of edges suggests limited evidence for a tightly connected module, so the label reflects a general developmental category rather than a specific function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0006517","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0071787","count":1},{"id":"GO:0071788","count":1}]},{"hash":"1739653510104953363","title":"RNA processing and translation initiation","description":"These proteins appear tied to RNA metabolism: terms for regulation of alternative mRNA splicing via the spliceosome and positive regulation of mRNA splicing, plus mRNA export from the nucleus and miRNA-mediated silencing, indicate RNA processing roles. At the same time, terms for forming the translation preinitiation complex and assembling the eIF4F complex point to translation initiation machinery. Together, the cluster likely represents regulators of post-transcriptional gene expression, bridging splicing/export with translation initiation.","confidence":"High","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":4},{"id":"GO:0048026","count":4},{"id":"GO:1900363","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0001731","count":4}]},{"hash":"2245674720761517535","title":"TNF-induced ubiquitin-proteasome regulation of apoptosis","description":"The top GO terms point to TNF-mediated signaling, ubiquitin-dependent protein degradation (including autoubiquitination and ERAD), and regulation of apoptosis and JNK signaling, all of which co-occur in pathways controlling cell fate via ubiquitin-proteasome\u2013driven turnover. Some listed terms (e.g., dosage compensation, histone methylation) appear less connected and may reflect annotation noise, but the core cluster consistently centers on TNF signaling intertwined with ubiquitin-dependent proteolysis and apoptotic regulation.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033209","count":6},{"id":"GO:0051865","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0090073","count":6}]},{"hash":"2250718475092469461","title":"Inflammatory signaling and cytokine regulation","description":"This cluster centers on immune and inflammatory pathways: inflammatory and LPS responses, cytokine and TNF production, and key signaling via NF-kappaB, JNK, PI3K/AKT, and STAT. The GO terms suggest coordinated regulation of immune activation and cytokine signaling, with a minor association to development that may reflect tissue remodeling during inflammation. Overall, the theme is inflammatory immune signaling.","confidence":"High","size":8,"edges":14,"triangles":16,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":6},{"id":"GO:0071260","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0032496","count":5}]},{"hash":"1043800553479803239","title":"Vertebrate neural and organ development","description":"The dominant GO terms span neural differentiation (retinal bipolar neuron differentiation; brain development) and various organ morphogenesis pathways (embryonic digit morphogenesis; pronephros and ureteric bud morphogenesis; neurohypophysis and heart-related septum development; neuromast differentiation), indicating a cluster of proteins involved in broad vertebrate development rather than a single function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051098","count":1},{"id":"GO:0060040","count":1},{"id":"GO:0044708","count":1},{"id":"GO:0021985","count":1},{"id":"GO:0048924","count":1}]},{"hash":"2090257815310058843","title":"DNA replication, repair, and transcription","description":"Based on the prominent GO terms, the proteins are most involved in nuclear DNA metabolism and gene expression: nucleotide-excision repair, DNA-templated DNA replication, DNA recombination, and transcription elongation by RNA polymerase II. Several terms about myelination, membrane localization, or host-symbiont interactions appear as single instances and do not form a cohesive theme, so the core signal is DNA replication/repair and transcription. Therefore the label captures the central shared function of the cluster, with some noise from outlier terms.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":1},{"id":"GO:0090002","count":1},{"id":"GO:0046854","count":1},{"id":"GO:0009432","count":1},{"id":"GO:0090305","count":1}]},{"hash":"1979218322649300929","title":"Meiosis and germ cell division","description":"The cluster is dominated by meiosis-related GO terms (spermatocyte division, male meiosis cytokinesis, meiotic chromosome condensation) and a G1/S transition term, indicating a focus on meiotic processes and germ cell division. Additional terms on translation initiation and stem cell maintenance may reflect regulatory connections in germ cells, but the strongest signal is meiosis and germline cell-cycle regulation.","confidence":"High","size":8,"edges":20,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048137","count":3},{"id":"GO:0000289","count":3},{"id":"GO:0007112","count":3},{"id":"GO:0000082","count":3},{"id":"GO:0016032","count":3}]},{"hash":"791843853719421300","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":16,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001680","count":2},{"id":"GO:0042245","count":2},{"id":"GO:1990180","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0007099","count":1}]},{"hash":"1291100702461061342","title":"Meiotic Recombination and DNA Repair","description":"The cluster is dominated by GO terms centered on meiosis and homologous recombination, such as meiotic joint molecule formation, mating-type switching and gene conversion at the mating-type locus, meiotic recombinase assembly, and double-strand break repair via homologous recombination, plus DNA strand invasion and a DNA damage response to ionizing radiation. These repeatedly point to meiosis-specific recombination and DNA repair functions, making the label representative despite a couple of less-representative terms.","confidence":"High","size":8,"edges":21,"triangles":25,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000709","count":2},{"id":"GO:0007533","count":2},{"id":"GO:0007534","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0010772","count":2}]},{"hash":"429054472537755196","title":"Infection defense and host-pathogen interactions","description":"These proteins show a pattern centered on antimicrobial defense and interactions with pathogens, with GO terms for defense response to bacterium, peptidoglycan and cell wall catabolic processes, cytolysis, and viral release from host cells. Some other terms (like energy metabolism and signaling) may reflect broader cellular roles or annotation noise, but the dominant signal aligns with host defense and pathogen handling.","confidence":"Medium","size":8,"edges":18,"triangles":19,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":7},{"id":"GO:0019835","count":7},{"id":"GO:0019076","count":7},{"id":"GO:0009253","count":7},{"id":"GO:0007194","count":7}]},{"hash":"1349766146169170705","title":"Bone resorption and ECM remodeling","description":"The GO terms are dominated by proteolysis, collagen catabolic processes, and regulation of osteoclast differentiation, all hallmarks of bone remodeling and extracellular matrix degradation. Additional terms related to protein stabilization and localization at cell junctions fit the structural and turnover context of matrix remodeling, while a few chromatin-related terms are less central. Therefore, the cluster is best described as bone resorption and ECM remodeling.","confidence":"Medium","size":8,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003094","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0045670","count":2},{"id":"GO:0042981","count":2},{"id":"GO:1902414","count":2}]},{"hash":"388456886328921155","title":"Unknown","description":"The GO terms attached to this cluster cover digestion, various metabolic processes (retinal, retinol, testosterone/androgen), signaling (Wnt), immune activity (complement activation), and tissue/homeostatic regulation, which do not converge on a single coherent function or pathway. Therefore there isn't a clear, representative label beyond Unknown.","confidence":"","size":8,"edges":13,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007586","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0042574","count":3},{"id":"GO:0061370","count":3},{"id":"GO:0008209","count":3}]},{"hash":"2204997680789159101","title":"Inflammation-driven angiogenesis and leukocyte migration","description":"Top terms cluster around immune and vascular remodeling processes: leukocyte migration in inflammatory response, positive regulation of angiogenesis, responses to cytokines (IL-13) and lipid/metabolic signals (response to cholesterol, glucose stimulus), and cell adhesion, all of which point to inflammation-associated vascular changes rather than a single enzymatic pathway. Some terms are broad or dated (obsolete PI3K signaling), but the dominant theme is inflammation-related angiogenesis and leukocyte trafficking.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0002523","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0034605","count":2}]},{"hash":"1716259742664728012","title":"Neural signaling and autonomic regulation","description":"The GO terms mostly point to neural communication and autonomic control, including dopaminergic synaptic transmission, neuropeptide signaling, and regulation of dopamine receptor signaling, as well as behavioral and pain-related processes (grooming behavior, sensory perception of pain). Developmental terms for the enteric nervous system and glands-related functions like saliva secretion further support autonomic innervation themes. A single term for thymocyte differentiation is less related, but overall the cluster centers on neural signaling networks and their regulation of physiology and behavior.","confidence":"High","size":8,"edges":18,"triangles":16,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":8},{"id":"GO:0072224","count":8},{"id":"GO:0060160","count":8},{"id":"GO:0048484","count":8},{"id":"GO:2000458","count":8}]},{"hash":"485573214176115734","title":"Chromatin organization and nucleosome assembly","description":"The top GO terms cluster around chromatin and nucleosome-related processes (nucleosome assembly, heterochromatin organization, chromatin localization) with supporting but few RNA/process terms, suggesting these proteins mainly function in chromatin architecture and nucleosome dynamics rather than metabolism or signaling.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":1},{"id":"GO:1990516","count":1},{"id":"GO:0006401","count":1},{"id":"GO:0016584","count":1},{"id":"GO:0006334","count":1}]},{"hash":"1768296253408343225","title":"Glycan biosynthesis and glycosylation","description":"Most terms describe production or modification of carbohydrate chains: lactose biosynthetic, hyaluronan biosynthetic, teichoic acid biosynthetic, cellulose biosynthetic; and glycosylation-related processes (O-linked glycosylation). This suggests the cluster groups enzymes and factors involved in assembling or decorating glycans and cell wall components. A couple of items (formation of infection structure, sperm binding to zona pellucida) may reflect glycan-mediated interactions or annotation noise, but overall the theme centers on carbohydrate biosynthesis.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":7},{"id":"GO:0007339","count":6},{"id":"GO:0006683","count":6},{"id":"GO:0030213","count":6},{"id":"GO:0021680","count":6}]},{"hash":"781639844150624182","title":"Cardiac Ion Homeostasis and Contraction","description":"The cluster\u2019s terms converge on ion homeostasis (sodium, potassium, calcium), ion transport across membranes, and cardiac muscle contraction, with supporting terms related to heart morphogenesis. This suggests proteins involved in maintaining cardiac ionic balance that supports heart contractile function, despite a minor brain-barrier term appearing as a less central note.","confidence":"High","size":8,"edges":15,"triangles":16,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060857","count":2},{"id":"GO:0061343","count":2},{"id":"GO:0006883","count":2},{"id":"GO:0036376","count":2},{"id":"GO:0006874","count":2}]},{"hash":"356436273413026440","title":"Lipid biosynthesis and signaling pathways","description":"The cluster shows strong signals for lipid production (very long-chain fatty acid biosynthesis, fatty acid elongation, sphingolipid biosynthesis) together with key signaling cascades (canonical NF-kappaB, JNK cascade) and Rho-mediated signaling, plus regulation of ER-Golgi transport, pointing to a module where lipid biosynthesis and intracellular signaling/trafficking are coordinated. Some virus-related terms may reflect host\u2013pathogen interactions rather than lipid-specific function, and cementum mineralization appears as an incidental outlier.","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042761","count":1},{"id":"GO:0046726","count":1},{"id":"GO:0045070","count":1},{"id":"GO:0030497","count":1},{"id":"GO:0007249","count":1}]},{"hash":"1432785834493319881","title":"Neuronal sensory signaling and synaptic transport","description":"The cluster centers on neural and sensory functions, with eye pigment granule organization and olfactory learning pointing to sensory systems, and anterograde synaptic vesicle transport indicating synaptic activity. Supporting terms emphasize cytoskeletal organization (tubulin complex and cortical microtubules) and protein homeostasis (folding, chaperone assembly, ubiquitin-proteasome quality control), which are crucial for neuronal transport and signaling. A broader transcription elongation term may reflect general neuronal gene expression regulation rather than a specific pathway, but the dominant theme remains neural signaling and cytoskeletal maintenance.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008057","count":2},{"id":"GO:0008355","count":2},{"id":"GO:0048490","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0035987","count":1}]},{"hash":"929209255929746897","title":"Fungal sterol and lipid metabolism","description":"The top GO terms cluster around sterol biosynthesis and modification (ergosterol regulation, sterol oxidation) and related lipid pathways (unsaturated fatty acid biosynthesis, MIPC sphingolipid metabolism). These together strongly suggest a fungal lipid/sterol metabolism theme, with a few terms likely representing broader or cross-species annotations. Overall, the dominant signal supports a fungal sterol/lipid metabolic cluster.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001949","count":2},{"id":"GO:0006809","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0032443","count":2},{"id":"GO:0042128","count":2}]},{"hash":"2184761176536274648","title":"Golgi-ER Vesicle Trafficking in Development","description":"This cluster centers on intracellular transport along the secretory pathway, including ER-to-Golgi and Golgi-to-transport vesicle processes, and lysosomal membrane organization, with accompanying developmental processes such as brain development and limb/digit morphogenesis, suggesting a theme of vesicle trafficking linked to development. ","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055108","count":2},{"id":"GO:0048066","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0097212","count":2},{"id":"GO:0051301","count":2}]},{"hash":"589102635322102352","title":"Neural development and synaptic signaling","description":"This cluster centers on brain development and neural communication: corpus callosum development, positive regulation of synapse assembly, dopamine response, and pain-related behavior; AKT signaling supports neuronal activity. Immune terms are present but appear ancillary to the main neural theme.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":2},{"id":"GO:0071222","count":2},{"id":"GO:1903351","count":2},{"id":"GO:0061368","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1047065435523968910","title":"Autophagy and organelle turnover","description":"These proteins show strong enrichment for autophagy-related processes: autophagosome maturation and assembly, autophagy of mitochondrion, reticulophagy, nucleophagy, and cytoplasm-to-vacuole targeting via the Cvt pathway, pointing to a cohesive theme of autophagy and organelle turnover; associated stress and developmental contexts further support autophagy activation.","confidence":"High","size":7,"edges":15,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":4},{"id":"GO:0000422","count":4},{"id":"GO:0040024","count":4},{"id":"GO:0044805","count":4},{"id":"GO:0061709","count":4}]},{"hash":"707313436297553289","title":"Genome Stability and DNA Repair","description":"The cluster is dominated by GO terms tied to maintaining genome integrity, including DNA damage response and p53-mediated apoptosis, replication fork arrest, repair of double-strand breaks, and meiotic recombination/gene conversion, plus regulation of helicase activity and maintenance of DNA repeats. These collectively point to a cohesive role in genome maintenance during cell division and development, with embryonic development likely reflecting the importance of genome integrity in early growth. ","confidence":"High","size":7,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":3},{"id":"GO:0042771","count":3},{"id":"GO:0061500","count":3},{"id":"GO:0010777","count":3},{"id":"GO:0051096","count":3}]},{"hash":"1685768014183957816","title":"Telomere maintenance regulation","description":"Dominant GO terms in this cluster center on telomere biology, including telomere maintenance via telomerase, telomere capping, and telomeric cohesion. A few terms related to electrical signaling and other processes appear, but the telomere-related terms are the strongest signal, suggesting the cluster mainly reflects telomere maintenance functions with some peripheral annotations. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010650","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0002268","count":2},{"id":"GO:0032212","count":2},{"id":"GO:1904908","count":2}]},{"hash":"389023958204913326","title":"Cell cycle control and cytoskeletal remodeling","description":"The cluster shows strong signals for mitotic transitions (G1/S and G2/M), transcription by RNA Pol II, and differentiation cues, along with cytoskeletal-related processes such as actin nucleation via Arp2/3, cell polarity, and endocytosis. This suggests a cohesive theme where cell cycle control is linked to cytoskeletal dynamics and differentiation programs, rather than isolated processes.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000082","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0006367","count":2},{"id":"GO:0007399","count":2}]},{"hash":"1496870860247775584","title":"Unknown","description":"The GO terms are scattered across nuclear processes (DNA-templated transcription, DNA replication, phosphorylation) and diverse stress/developmental categories (response to X-ray, antibiotic, Purkinje cell morphogenesis, isotype switching, lipid homeostasis), with no clear common function binding the proteins. This heterogeneity suggests no single representative function for the cluster. ","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0045190","count":2},{"id":"GO:0010165","count":2},{"id":"GO:0016310","count":2}]},{"hash":"733818881234357974","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0016575","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0006349","count":6},{"id":"GO:0000466","count":6}]},{"hash":"1044093360589658749","title":"RNA processing and transcription regulation cluster","description":"Top GO terms center on transcription and RNA processing: pre-miRNA processing; DNA-templated transcription; transcription antitermination; miRNA catabolic process; CRD-mediated mRNA stabilization. A few terms involve DNA integration and proviral latency, but the dominant signal is RNA biogenesis coupled to transcriptional control.","confidence":"Medium","size":7,"edges":15,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0031054","count":2},{"id":"GO:0060567","count":2},{"id":"GO:0031564","count":2},{"id":"GO:1901724","count":2},{"id":"GO:0070934","count":2}]},{"hash":"216539980579130197","title":"Ribosome Biogenesis and Growth Regulation","description":"The top terms center on protein synthesis and growth: ribosome biogenesis and formation of translation preinitiation complex, along with cell division and cytoskeletal regulation, indicating a focus on growth and proliferation with associated stress responses (ER stress\u2013related apoptosis). Some terms (SREBP signaling, histone deacetylation) are less tightly tied, possibly reflecting broader annotations, but the core theme points to ribosome production and growth control.","confidence":"Medium","size":7,"edges":9,"triangles":4,"max_degree":5,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0001731","count":7},{"id":"GO:0032933","count":7},{"id":"GO:1904668","count":7},{"id":"GO:0016575","count":6},{"id":"GO:0042254","count":6}]},{"hash":"786829946274773455","title":"Retroviral Integration and Latency","description":"Enriched terms cluster around steps of the retroviral life cycle: proviral latency establishment, DNA integration into the host genome, RNA-templated DNA biosynthesis (reverse transcription), and viral entry into the host nucleus. Additional terms about symbiont entry and host apoptosis reflect host-pathogen interaction contexts but do not outweigh the core retroviral theme. Overall, the cluster seems representative of retroviral DNA integration and latency with host interaction.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0006278","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1715735507960283877","title":"Epigenetic Regulation of Gene Expression","description":"Based on the Top Terms, the cluster centers on transcription control (DNA-templated transcription; regulation of transcription by RNA polymerase II) and chromatin-related processes (epigenetic programming of gene expression; histone turnover; heterochromatin formation). These together point to regulation of gene expression via epigenetic and chromatin mechanisms, rather than purely signaling or metabolic roles. Some terms like abscisic acid response or uterus morphogenesis are more context-specific but do not override the core theme.","confidence":"High","size":7,"edges":16,"triangles":17,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0032968","count":2},{"id":"GO:0009737","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1901536","count":2}]},{"hash":"1833510904268864274","title":"Embryonic Development and Organ Morphogenesis","description":"This cluster is dominated by GO terms related to embryogenesis and tissue/organ formation, including left-right patterning, placenta development, heart/endocardial cushion formation, cartilage morphogenesis, trophoblast differentiation, and pancreatic cell development. While a couple of terms pertain to general cellular processes, the overall signal points to developmental processes and morphogenesis.","confidence":"High","size":7,"edges":13,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3}]},{"hash":"37090056610901956","title":"APC/C-Driven Mitosis and Ubiquitination","description":"The dominant GO terms point to mitotic progression regulated by ubiquitin-mediated degradation, including APC/C-dependent catabolic processes and protein polyubiquitination, with related cell cycle terms (mitotic cell cycle, cell division). The presence of ubiquitin pathways supports a coherent theme of regulated proteolysis during division; minor signals like ribosome biogenesis and cadmium response are less central to this cluster\u2019s core function.","confidence":"High","size":7,"edges":7,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0031145","count":4},{"id":"GO:2001162","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0030433","count":4}]},{"hash":"1260208610450274490","title":"LPS-induced NF-kB and ERK signaling","description":"The top GO terms cluster around lipopolysaccharide signaling, NF-kappaB activity, ERK/MAPK cascades, and PI3K-AKT signaling, all indicative of innate immune and inflammatory responses. Also present are defense against bacteria and viral replication regulation, supporting a cohesive theme of host defense signaling. A noncore term about hair follicle development appears as potential noise. Overall, this cluster reflects LPS-triggered inflammatory signaling and NF-kB/ERK pathway activation.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0031663","count":3},{"id":"GO:1903140","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0043491","count":2}]},{"hash":"1159021763666104004","title":"Developmental Patterning and Organogenesis","description":"The GO terms point to developmental processes across multiple tissues (hippocampus, kidney, fat tissue, pectoral fin) with related events like sarcomere organization and apoptosis, suggesting a general theme of embryonic tissue formation and organogenesis rather than a single molecular function.","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021766","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0043001","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0043277","count":2}]},{"hash":"873257293323562677","title":"Proteostasis and cytoskeletal stress response","description":"The terms cluster around protein homeostasis (folding, translational attenuation, proteasomal regulation) and cytoskeletal dynamics (actin rod assembly), with supporting signals of stress responses (salt stress) and membrane trafficking (protein localization to cell surface). Together these point to a theme of cellular stress coping that links proteostasis with cytoskeletal remodeling and surface protein trafficking. ","confidence":"Medium","size":7,"edges":15,"triangles":16,"max_degree":6,"top_function":"protein folding","top_go_terms":[{"id":"GO:2000010","count":5},{"id":"GO:0045793","count":5},{"id":"GO:0006457","count":5},{"id":"GO:1901389","count":5},{"id":"GO:0032435","count":5}]},{"hash":"2037187277172896443","title":"Vesicle trafficking and secretory pathway","description":"Most prominent GO terms are COPII-coated vesicle cargo loading and intracellular protein transport, pointing to components of the secretory pathway and vesicle trafficking. Additional terms touch on mRNA processing, transcription, centrosome duplication, lumen formation, planar polarity, autophagy, and morphogenesis, suggesting a broader cellular-organization theme but with a clear emphasis on intracellular transport. Therefore the label Vesicle trafficking and secretory pathway captures the cluster's central theme, with peripheral development-related terms.","confidence":"Medium","size":7,"edges":8,"triangles":3,"max_degree":5,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0090110","count":3},{"id":"GO:0006886","count":3},{"id":"GO:0006397","count":2},{"id":"GO:0051298","count":2},{"id":"GO:0006351","count":2}]},{"hash":"572334560238375738","title":"Planar polarity signaling and axon guidance","description":"The top GO terms center on planar cell polarity (planar polarity establishment, PCP pathway-related roles) and axon guidance (dopaminergic/serotonergic neuron guidance), with supporting terms like receptor clustering and protein localization in polarity. Additional morphogenesis terms (lung branching, epiboly) fit into PCP-related developmental processes. Together, these terms point to a cluster of proteins involved in planar polarity signaling that guides neural wiring and tissue organization during development.","confidence":"High","size":7,"edges":15,"triangles":20,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007213","count":7},{"id":"GO:0036514","count":7},{"id":"GO:0048105","count":7},{"id":"GO:0060490","count":7},{"id":"GO:0060489","count":7}]},{"hash":"1680720199901883969","title":"Interferon signaling and MHC I antigen processing","description":"This cluster centers on immune-related GO terms, including positive regulation of type II interferon signaling, IL-18 production, and MHC class I biosynthesis, pointing to enhanced antigen presentation and IFN-driven responses. The presence of actin cytoskeleton remodeling terms and GTPase regulation suggests coordinated cytoskeletal changes that support immune activation. The metanephros morphogenesis term appears less connected to the main theme, so the core is immune signaling with cytoskeletal dynamics.","confidence":"Medium","size":7,"edges":12,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0003338","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0032088","count":1},{"id":"GO:0032741","count":1}]},{"hash":"1218909919270145651","title":"Neural development and synapse formation","description":"The dominant GO terms point to nervous system development and synaptic assembly, including forebrain development, neuromuscular junction assembly, and visual learning. Additional terms for integrin signaling and collagen fibril organization suggest ECM-related processes that support neural development and synaptogenesis. Taken together, the proteins likely function in neural development and synapse formation.","confidence":"High","size":7,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0051124","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0007229","count":3}]},{"hash":"242289936489515707","title":"Multitissue Development and Differentiation","description":"The top GO terms cluster around tissue development and cell fate decisions across multiple lineages (cardioblast differentiation, spinal cord interneuron differentiation, nephric duct formation, eosinophil fate commitment) plus hormonal regulation (estrogen response, thyroid hormone generation) and tissue homeostasis, suggesting a broad theme of developmental differentiation and organogenesis with regulatory control rather than a single pathway.","confidence":"Medium","size":7,"edges":17,"triangles":21,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048873","count":6},{"id":"GO:1902499","count":6},{"id":"GO:0035854","count":5},{"id":"GO:0090295","count":5},{"id":"GO:0051891","count":5}]},{"hash":"2121338126924135697","title":"Unknown","description":"The GO terms span diverse biological contexts (vulval fate specification, eye morphogenesis, bone resorption, neuron projection development, fat cell differentiation, heat response, mechanosensation, pinocytosis, and electrical coupling) with no single cohesive function, making a specific, representative cluster label unsupported.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0072327","count":1},{"id":"GO:2000495","count":1},{"id":"GO:0045453","count":1},{"id":"GO:0031175","count":1},{"id":"GO:0045444","count":1}]},{"hash":"2159745272093392317","title":"Developmental signaling and cell-cycle regulation","description":"The cluster is characterized by GO terms for positive regulation of kinase and GTPase activities (signal transduction), mitotic cytokinesis (cell division), and various developmental processes including endodermal fate commitment and oocyte localization, plus apoptosis-related morphogenesis and nuclear import of ribosomal proteins. These together suggest a general theme of coordinating signaling, proliferation, and programmed cell fate during development, despite some unrelated terms such as fungiform papilla formation.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033674","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0000281","count":2},{"id":"GO:0060135","count":1},{"id":"GO:0060561","count":1}]},{"hash":"2073913558440024165","title":"Embryonic organogenesis and tissue differentiation","description":"These GO terms cluster around developmental processes across multiple tissues (kidney metanephros development and ureteric bud branching; thymus; odontogenesis; hair follicle morphogenesis; melanocyte differentiation; blood vessel remodeling). The common thread is broad developmental differentiation and organogenesis rather than a single biochemical pathway, so the label emphasizes generalized developmental roles. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0030318","count":2},{"id":"GO:0045668","count":2},{"id":"GO:0001658","count":2},{"id":"GO:0001656","count":2}]},{"hash":"1285923988170295369","title":"Immune Activation and Inflammatory Signaling","description":"The top GO terms emphasize inflammatory response, IL-1 response, and regulation of T cell activation/death, plus endothelial barrier regulation, pointing to an immune/inflammatory theme. Other terms (cardiac action potential, salivary gland development, amyloid formation) appear less cohesive with a single function, likely reflecting broad annotations rather than a single pathway.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010881","count":1},{"id":"GO:0006924","count":1},{"id":"GO:0086005","count":1},{"id":"GO:0010956","count":1},{"id":"GO:0070555","count":1}]},{"hash":"835673666003660472","title":"ECM organization and cell adhesion","description":"The most represented GO terms center on extracellular matrix assembly and interactions (collagen fibril organization, integrin biosynthetic process, tendon development) and coordination of cell\u2013cell signaling (synapse assembly), along with vascular tissue remodeling (lymphangiogenesis). These together point to an ECM remodeling and cell adhesion\u2013driven tissue development theme, with some metabolic terms appearing as peripheral connections. Confidence: Medium","confidence":"","size":7,"edges":15,"triangles":14,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0030199","count":6},{"id":"GO:1901492","count":4},{"id":"GO:2000590","count":4},{"id":"GO:0046326","count":4}]},{"hash":"1267477705181552878","title":"Developmental differentiation and cytoskeleton remodeling","description":"These proteins show enrichment in developmental patterning and organogenesis terms (germarium-derived oocyte fate determination, endodermal cell fate commitment, renal vesicle formation, superior colliculus development) alongside cytoskeletal remodeling and membrane trafficking (mitotic cytokinesis, barbed-end actin filament capping, negative regulation of filopodium assembly, vacuole fusion) and related growth signaling (insulin receptor pathway regulation). This suggests a cohesive theme of developmental differentiation coupled with cytoskeletal and vesicle dynamics.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000281","count":2},{"id":"GO:0042144","count":2},{"id":"GO:0046626","count":2},{"id":"GO:0007294","count":1},{"id":"GO:0051490","count":1}]},{"hash":"754260312537674155","title":"Dopaminergic Neuronal Signaling and Behavior","description":"The cluster is dominated by terms related to neuronal signaling and behavior, especially dopamine-related processes (synaptic transmission dopaminergic, regulation of dopamine receptor signaling) and neuropeptide signaling, plus related nervous system development terms (enteric nervous system development, astrocyte chemotaxis regulation, sensory perception of pain, grooming behavior). While a couple terms touch non-neural processes (saliva secretion, metanephric glomerulus development), the prominent theme centers on dopaminergic signaling and neural communication underpinning behavior. ","confidence":"High","size":7,"edges":5,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":7},{"id":"GO:0072224","count":7},{"id":"GO:0060160","count":7},{"id":"GO:0048484","count":7},{"id":"GO:2000458","count":7}]},{"hash":"1544346580954750180","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":14,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019552","count":3},{"id":"GO:0006633","count":3},{"id":"GO:2001295","count":3},{"id":"GO:0042759","count":3},{"id":"GO:0044268","count":3}]},{"hash":"230860748184703970","title":"Neurotransmitter biosynthesis and circadian rhythm","description":"The terms show multiple neurotransmitter biosynthesis pathways (GABA, dopamine, histamine) and related metabolism (glutamate), plus a circadian rhythm term, pointing to a neural signaling and temporal-regulation theme. Sphingolipid metabolism also fits with neuronal membranes and signaling, supporting a neurological cluster, while unrelated terms like aging or anesthesia-resistant memory are less central. Overall, the data coalesce around neural chemical signaling and daily timing.","confidence":"Medium","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071312","count":3},{"id":"GO:0010259","count":3},{"id":"GO:0007615","count":3},{"id":"GO:0009449","count":3},{"id":"GO:0006665","count":3}]},{"hash":"1297585682387876517","title":"Mitochondrial Electron Transport and ATP Synthesis","description":"The top GO terms are dominated by energy metabolism: aerobic respiration, mitochondrial electron transport chain activity (including complex III assembly and ubiquinol to cytochrome c), proton transmembrane transport, and ATP synthesis coupled to electron transport. This pattern strongly suggests a cluster of proteins involved in oxidative phosphorylation and energy production in mitochondria. Some terms related to photosynthesis and methanogenesis appear as minor signals, possibly reflecting broader energy-related annotations or cross-domain proteins, but the prevailing theme is mitochondrial respiration.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":3},{"id":"GO:1902600","count":3},{"id":"GO:0019684","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0072593","count":2}]},{"hash":"1286122478827670097","title":"Embryonic organogenesis and growth","description":"Based on the top GO terms, the proteins are enriched for developmental processes including pancreas morphogenesis, digestive system development, midbrain development, and post-embryonic growth, along with a theme of transcriptional regulation by RNA polymerase II, pointing to a cohesive role in organ formation and growth with transcriptional control. Some terms related to immune response and glucose signaling are present but appear ancillary to the main developmental theme.","confidence":"High","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0061113","count":7},{"id":"GO:0009791","count":7},{"id":"GO:0035264","count":7},{"id":"GO:0045944","count":7},{"id":"GO:0003050","count":7}]},{"hash":"73824037411731268","title":"Complement signaling and phagolysosome function","description":"This cluster is dominated by innate immune terms: complement receptor mediated signaling, activation of membrane attack complex, and phagolysosome assembly, pointing to immune activation and intracellular degradation. Some terms touch on development, cell adhesion, and migration, which can reflect broader roles of immune cells in tissue remodeling and angiogenesis. Overall, the strongest cohesive theme centers on complement-mediated signaling and phagolysosome function.","confidence":"Medium","size":7,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043129","count":2},{"id":"GO:0060244","count":2},{"id":"GO:0006924","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0090050","count":2}]},{"hash":"247066040329813539","title":"Unknown","description":"The top GO terms span circadian locomotor rhythm, vascular development, GPCR-cAMP signaling, pain response, transcription regulation, and various developmental processes, with no clear single function tying all proteins together, so a cohesive label isn\u2019t evident.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045475","count":2},{"id":"GO:0001570","count":2},{"id":"GO:0007189","count":2},{"id":"GO:0048265","count":2},{"id":"GO:0006171","count":2}]},{"hash":"1952875046753506964","title":"Bacterial menaquinone and lipid metabolism","description":"This cluster is dominated by GO terms tied to quinone biosynthesis (menaquinone), lipoteichoic acid synthesis, fatty acid metabolism (long-chain and very long-chain), and acetyl-CoA\u2013related pathways (biosynthesis from acetate, pyruvate fermentation to acetate). Together, these point to central metabolic and cell envelope lipid/quionone biosynthesis processes typical of bacteria, especially Gram-positive organisms. Some outlier terms like seed coat development or bile acid metabolism may reflect annotation noise rather than core function. ","confidence":"Medium","size":7,"edges":8,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":3},{"id":"GO:0010214","count":2},{"id":"GO:0070395","count":2},{"id":"GO:0019427","count":2},{"id":"GO:0008206","count":2}]},{"hash":"955034491125901179","title":"Germline Polarity and Development Regulation","description":"The prominent GO terms point to germ plasm and pole plasm functions (oskar mRNA localization), germline specification, and broader developmental gene regulation (neuron differentiation, transcription regulation, stem cell maintenance). Although viral-related terms appear, the strongest signal is germline/pole plasm\u2013centered development and regulation of gene expression. This suggests a cluster of proteins linked to germline polarity and developmental control rather than a single metabolic pathway.","confidence":"Medium","size":7,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008582","count":2},{"id":"GO:0007317","count":2},{"id":"GO:0007143","count":2},{"id":"GO:0019827","count":2},{"id":"GO:0045665","count":2}]},{"hash":"803162815416576442","title":"RNA and protein methylation","description":"The cluster is dominated by GO terms for various methylation reactions, including RNA methylation (guanine-N7, mRNA capping, tRNA), rRNA modification, and arginine and histone methylation. This pattern points to a shared role for enzymes that transfer methyl groups, affecting both nucleic acids and proteins. Additional terms on cobalamin and antibiotic biosynthesis are consistent with methyltransferase-type activities involved in secondary metabolism, reinforcing the methylation-centered theme. The inclusion of cell growth and cellular senescence terms may reflect downstream regulatory consequences of altering methylation states.","confidence":"High","size":7,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":5},{"id":"GO:0009236","count":5},{"id":"GO:0006370","count":4},{"id":"GO:0030488","count":4},{"id":"GO:0043985","count":4}]},{"hash":"2220503330934901219","title":"Cell cycle, cytokinesis, and translation","description":"This cluster centers on cell cycle progression (cell cycle; exit from mitosis) and cytokinesis-associated processes (septin ring disassembly, cell septum assembly, regulation of exocytosis, embryonic cell shape), with translation-related functions (cytoplasmic translation; ribosome biogenesis) suggesting a link to protein synthesis during division. The combination points to a cohort involved in growth and division, coordinating cell cycle control with cytoskeletal remodeling and protein production, hence a cohesive but broad cell-division/signaling theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0010458","count":1},{"id":"GO:0017157","count":1},{"id":"GO:0016476","count":1}]},{"hash":"1578646704980727239","title":"Bacterial lipid metabolism and energy pathways","description":"The cluster's GO terms cluster around lipoteichoic acid biosynthesis, long- and very long-chain fatty acid metabolism, acetyl-CoA biosynthesis, menaquinone biosynthesis, bile acid metabolism, and pyruvate fermentation to acetate, which together point to bacterial lipid biosynthesis and central energy metabolism. A plant seed coat term appears less consistent and may reflect annotation noise, but the dominant themes are lipid processing and energy generation in bacteria.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010214","count":7},{"id":"GO:0070395","count":7},{"id":"GO:0019427","count":7},{"id":"GO:0008206","count":7},{"id":"GO:0044539","count":7}]},{"hash":"1649051550488104921","title":"Innate immune and inflammatory signaling","description":"This cluster shows a clear enrichment for innate immune response (2) and inflammatory response, with additional terms related to immune signaling such as interleukin-18 production. While there are also neural development and signaling terms (Wnt signalosome, axon guidance, synapse assembly, pain), the immune-related terms dominate, justifying a label focused on innate immunity and inflammation.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0009934","count":1},{"id":"GO:1904887","count":1},{"id":"GO:0032741","count":1},{"id":"GO:0072224","count":1}]},{"hash":"1558647377047961624","title":"Growth Factor Signaling in Neural Development and Angiogenesis","description":"The top GO terms cluster around growth-factor\u2013driven signaling pathways (FGFR, VEGF/PDGFR, PI3K, JNK, STAT) connected to nervous system development and angiogenesis, including cortex-related development terms. An outlier immune term exists, but the dominant pattern supports a neural-vascular signaling theme.\\ ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0071333","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0035607","count":3}]},{"hash":"1483318602366195574","title":"Complement and Coagulation in Vascular Remodeling","description":"The cluster centers on immune and coagulation pathways (complement activation, coagulation, plasminogen activation, fibrinolysis) and vascular remodeling processes (angiogenesis, smooth muscle cell migration), with supporting signals from LPS response and ANP-regulated blood pressure, indicating a vascular immune-hemostatic remodeling program.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0003050","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0032496","count":4}]},{"hash":"924661507110527388","title":"Neural Signaling and Visual Perception","description":"Most terms point to neural signaling and sensory processing: GPCR signaling, light detection, electrical response, and memory, suggesting a neural/visual perception function. A few terms (oocyte maturation, amino acid biosynthesis, fungicide response) are less coherent with this theme and may reflect broad annotations. Overall, name reflects the strongest signals in the cluster.","confidence":"Medium","size":7,"edges":18,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":7},{"id":"GO:0035725","count":7},{"id":"GO:0030818","count":7},{"id":"GO:0009094","count":7},{"id":"GO:0060992","count":7}]},{"hash":"345590486591967059","title":"Cell migration and mechanotransduction regulation","description":"The prominent terms are cell migration and cellular response to mechanical stimulus, indicating a theme around cell motility and response to mechanical cues. Protein ubiquitination often regulates these processes, supporting a regulatory layer. While other terms (nucleotide catabolism, isoprenoid biosynthesis, snoRNA turnover) are present, the strongest coherent theme centers on cell movement and mechanotransduction. ","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0071260","count":3}]},{"hash":"722034397517558888","title":"Neurodevelopmental signaling and angiogenesis","description":"Several top GO terms cluster around nervous system development, neuroblast proliferation, sprouting angiogenesis, and Wnt signaling, with additional links to cell division and mitotic cycles. This pattern suggests a group of proteins involved in developmental signaling that coordinates neural development and vascular remodeling, with broader roles in tissue growth; peripheral terms like heart contraction and bone resorption may reflect broader developmental context rather than core function. ","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0045453","count":2},{"id":"GO:0043154","count":2}]},{"hash":"1201164686984817431","title":"Neural signaling and development","description":"The terms are dominated by neural-related processes: neuropeptide signaling, sensory perception of pain, grooming behavior, enteric nervous system development, astrocyte chemotaxis, and regulation of dopamine receptor signaling. While a few terms touch on non-neural areas (peptidoglycan catabolic process, saliva secretion, kidney development), the overarching pattern points to neurophysiology and development. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0009253","count":4},{"id":"GO:0046541","count":3},{"id":"GO:0072224","count":3},{"id":"GO:0060160","count":3},{"id":"GO:0048484","count":3}]},{"hash":"1222754280807116769","title":"Immune cell activation and inflammatory signaling","description":"The terms emphasize activation and regulation of immune cells (T and B cell activation, chemokine production) and inflammatory signaling (LPS response, IL-1 pathway regulation, STAT phosphorylation). A few development-related terms are present but the dominant theme is immune activation and inflammatory signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":3},{"id":"GO:0042102","count":2},{"id":"GO:0032722","count":2},{"id":"GO:0060445","count":2},{"id":"GO:0042517","count":2}]},{"hash":"650043469868874225","title":"Embryonic Morphogenesis Across Tissues","description":"The top GO terms revolve around embryonic development and tissue morphogenesis across multiple organ systems (brain, neurohypophysis, cranial skeleton, digits, and pronephros), suggesting a shared role in coordinating developmental shape changes rather than a single tissue-specific function.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051098","count":7},{"id":"GO:0044708","count":7},{"id":"GO:0021985","count":7},{"id":"GO:0090190","count":7},{"id":"GO:0007420","count":7}]},{"hash":"848566417365829400","title":"Embryonic neurocranial and organ morphogenesis","description":"The top GO terms span brain development, neurohypophysis development, embryonic cranial skeleton morphogenesis, embryonic digit morphogenesis, septum secundum development, and ureteric bud morphogenesis, plus related organ size regulation. Together they point to a cohesive theme of early embryonic morphogenesis across neural, craniofacial, cardiac, and renal tissues, rather than a single pathway. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051098","count":7},{"id":"GO:0044708","count":7},{"id":"GO:0021985","count":7},{"id":"GO:0090190","count":7},{"id":"GO:0007420","count":7}]},{"hash":"305554704579993248","title":"Membrane domains and tight junctions","description":"The top GO terms converge on membrane organization and cell\u2013cell junctions (membrane raft polarization, tight junction assembly, endothelial barrier establishment), suggesting a core theme of membrane domain organization. The other terms (neural and immune processes, apoptosis signaling) seem peripheral but can be tied to specialized tissues where membrane organization is crucial. Overall, the cluster centers on membrane domain and junctional functions.","confidence":"Medium","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":1},{"id":"GO:0002337","count":1},{"id":"GO:0035208","count":1},{"id":"GO:0001766","count":1},{"id":"GO:0070830","count":1}]},{"hash":"158750309059575327","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The terms cluster around actin dynamics\u2014actin filament network formation, formin-nucleated actin cable assembly, and related muscle filament assembly\u2014tied to cell movement and morphogenesis (substrate-dependent migration; developmental invasion and patterning). While there are immune and retinoic acid response signals, the dominant shared function appears to be actin remodeling driving cell migration and tissue morphogenesis, justifying this label.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0032526","count":2},{"id":"GO:2000251","count":1},{"id":"GO:0051639","count":1},{"id":"GO:0072092","count":1}]},{"hash":"500339173151843813","title":"T cell activation and inflammatory signaling","description":"This cluster features GO terms tied to adaptive immunity and inflammatory pathways: myeloid dendritic cell differentiation, T cell receptor signaling, positive regulation of T cell proliferation, TNF-mediated signaling, IL-6 production, and NF-kappaB regulatory activity. Together, they indicate proteins involved in T-cell activation and cytokine-driven inflammatory responses. A few developmental terms (neural tube closure, apical constriction) appear as less representative annotations, but the dominant signal is immune signaling.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043011","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0032088","count":2},{"id":"GO:0042102","count":2}]},{"hash":"1784197627850272927","title":"Golgi-ER vesicle trafficking and SNARE-mediated exocytosis","description":"The terms point to vesicle transport between the ER and Golgi, intra-Golgi and retrograde transport, SNARE complex assembly, Golgi ribbon formation, and secretory granule degranulation in immune cells, uniting core vesicle trafficking with exocytosis pathways.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0035493","count":3},{"id":"GO:1900483","count":3},{"id":"GO:0090161","count":3},{"id":"GO:0006891","count":3}]},{"hash":"2250275188410798514","title":"Developmental energy metabolism in liver and heart","description":"The cluster centers on liver and heart development terms alongside metabolic pathways such as carnitine and fatty acid oxidation and the TCA cycle, indicating proteins involved in developmental regulation linked to energy metabolism and nutrient processing (including starvation response).","confidence":"High","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":3},{"id":"GO:0042594","count":3},{"id":"GO:0006099","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0019254","count":2}]},{"hash":"1232746574814115921","title":"Vesicle trafficking and membrane fusion","description":"The top GO terms cluster around vesicle docking and SNARE complex assembly, and include positive regulation of protein/receptor localization to cell surfaces and synapses, as well as related processes like autophagosome maturation and Golgi disassembly. The presence of acrosome reaction and cornified envelope assembly further supports secretory vesicle fusion across different cell types. Together, these terms suggest a shared theme of vesicle trafficking and membrane fusion rather than a single highly specific pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0016081","count":5},{"id":"GO:2000010","count":5},{"id":"GO:0097352","count":5},{"id":"GO:1902685","count":5},{"id":"GO:0035493","count":5}]},{"hash":"977060184726744569","title":"Golgi Vesicle Trafficking","description":"The GO terms cluster around Golgi and vesicle transport processes (intra-Golgi vesicle transport, Golgi ribbon formation, SNARE complex assembly, retrograde transport to the Golgi, and vacuole fusion), indicating a core theme of the secretory pathway and Golgi-mediated trafficking. Peripheral terms like neutrophil degranulation and insulin response still fit within secretory and vesicle trafficking contexts, supporting a cohesive label. High","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043134","count":1},{"id":"GO:0035493","count":1},{"id":"GO:1900483","count":1},{"id":"GO:0090161","count":1},{"id":"GO:0006891","count":1}]},{"hash":"1995369924856888799","title":"Neural development and vesicle trafficking","description":"This cluster prominently features brain development and neuroblast proliferation terms, suggesting a neural development focus. It also includes several vesicle trafficking processes (COPII-coated vesicle budding and endosome-to-melanosome transport), which are essential for proper neuronal development and protein sorting. Other terms like ribosome biogenesis and DNA replication point to general cellular growth but are less defining. Overall, the neural development signal combined with intracellular transport points to a Neural development and vesicle trafficking theme.","confidence":"Medium","size":6,"edges":8,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":2},{"id":"GO:0060047","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0045740","count":2},{"id":"GO:0042254","count":1}]},{"hash":"1228569761710539962","title":"Neuronal survival and signaling regulators","description":"The set includes both positive and negative regulation of neuron apoptotic processes, along with factors influencing key signaling pathways (Wnt, ERK) and general regulatory processes like GTPase activity and the cell cycle. While not confined to a single pathway, the common thread is regulation of cell signaling and neuronal survival, suggesting these proteins act as broad modulators of signaling with a neuronal survival emphasis.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0090263","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0043525","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1660444883360350111","title":"Neurodevelopment and morphogenesis","description":"This cluster combines neural development signals (axon extension, dendritic spine morphogenesis, vocalization behavior) with broad morphogenetic processes (dorsal closure, tracheal/open tube and outflow tract morphogenesis), suggesting coordinated development and neural wiring. The presence of regulation of protein tyrosine kinase activity and microtubule organization supports signaling and cytoskeletal changes typical of these processes.","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0061098","count":6},{"id":"GO:0007394","count":6},{"id":"GO:0035159","count":6},{"id":"GO:0003151","count":5},{"id":"GO:0048675","count":5}]},{"hash":"1311715842714395608","title":"Translational Regulation and DNA Damage Response","description":"The cluster features terms tied to translational initiation and its regulation (preinitiation complex formation, IRES-dependent initiation) alongside DNA damage and repair processes (DNA repair, SOS response, DNA replication), suggesting a coordinated response linking protein synthesis control with genome maintenance, potentially in developmental contexts.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0048140","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0000338","count":3}]},{"hash":"1936492669080282267","title":"Neural development and apoptosis signaling","description":"This cluster centers on brain development terms (cerebral cortex development, corpus callosum development, regulation of axon regeneration) combined with apoptosis and stress-response pathways (apoptotic process, ER-stress\u2013driven apoptotic signaling, JNK cascade regulation, DNA damage checkpoint signaling) and survival signals (negative regulation of anoikis). Together they suggest proteins coordinating neural maturation with cell survival and stress responses, though a couple of terms (meiotic DSB formation) may reflect broad annotations. ","confidence":"Medium","size":6,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0007095","count":3},{"id":"GO:2000811","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0046329","count":2}]},{"hash":"499175779000454300","title":"Proteasome-Deneddylation Machinery and Translation Control","description":"This cluster centers on the ubiquitin-proteasome system and the COP9 signalosome, with terms for proteasome assembly and proteolysis, deneddylation and its regulation, and COP9 signalosome assembly, plus links to translation initiation and its regulation. The presence of NF-kappaB signaling and DNA repair-related terms suggests a broader regulatory network where protein turnover and post-translational modification (deneddylation) influence signaling and genome maintenance, but the dominant theme is proteostasis and its connection to translation control. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000338","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0007250","count":1},{"id":"GO:0010387","count":1},{"id":"GO:0043248","count":1}]},{"hash":"1429976053899319073","title":"Nuclear RNA Processing and Innate Immune Signaling","description":"This cluster shows strong representation of nuclear RNA metabolism: mRNA processing, transcription by RNA polymerase II, and rRNA maturation, suggesting a core theme of RNA processing and transcription control. The presence of lipopolysaccharide- and dsRNA-related GO terms indicates concurrent activation of innate immune pathways, which often engage transcriptional responses in epithelial cells. Keratinocyte differentiation and apoptotic terms may reflect downstream cellular responses to immune signaling. Taken together, the cluster seems to center on nuclear RNA processing with linked innate immune signaling in a skin-related context.","confidence":"Medium","size":6,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0071222","count":2}]},{"hash":"231323291150442276","title":"Chromatin Regulation via Methylation and Deubiquitination","description":"The top GO terms point to histone methylation (H3-K4 and H3-K79) and DNA-templated transcription, complemented by deubiquitination and ubiquitin recycling. This suggests a core function in chromatin modification and transcriptional control, with ubiquitin-related regulation as a key supporting theme. Other terms (Golgi retention, mRNA processing bodies, and plant-specific development terms) are fewer and likely represent peripheral or multifunctional associations, but the dominant signal is chromatin-based regulation of transcription.","confidence":"Medium","size":6,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051568","count":2},{"id":"GO:0034729","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0071560","count":2},{"id":"GO:1990108","count":1}]},{"hash":"834352421324887259","title":"Pro-Apoptotic Signaling and Cytoskeletal Regulation","description":"The cluster is dominated by GO terms for promoting apoptosis (positive regulation of apoptotic process and execution phase of apoptosis), suggesting proteins that drive cell death signaling. Supporting terms indicate roles in cytoskeletal localization and cell migration, implying linkage to cytoskeleton remodeling and GTPase signaling. A few minor terms (lipid storage, cytokine regulation) are less central. Overall, a coherent theme is apoptosis signaling with cytoskeletal dynamics.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043065","count":3},{"id":"GO:0097194","count":2},{"id":"GO:0072699","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0043547","count":2}]},{"hash":"2302852152048528768","title":"Developmental Regulation and Protein Homeostasis","description":"The cluster includes GO terms tied to developmental processes (trophoblast migration, vasculogenesis, stem cell maintenance, olfactory nerve organization) and regulatory processes (positive regulation of transcription by RNA polymerase II; negative regulation of ERK signaling) as well as protein homeostasis mechanisms (ribophagy, autoubiquitination, peptidyl-prolyl isomerization). This suggests a theme of coordinating cellular state during development through gene expression, signaling modulation, and protein quality control.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0045944","count":6},{"id":"GO:2000780","count":6},{"id":"GO:0034517","count":6},{"id":"GO:0051865","count":6},{"id":"GO:0070373","count":6}]},{"hash":"2046558557628624170","title":"Cytoskeletal and neuronal morphogenesis","description":"Most top GO terms point to cytoskeletal and adhesion processes (sarcomere organization, actomyosin structure organization, cell-matrix adhesion) along with neuronal development (dendritic spine morphogenesis, neuron migration, dopaminergic neuron differentiation). This suggests a cluster centered on cytoskeletal-driven morphogenesis in muscle and neural contexts, with a few peripheral terms.","confidence":"Medium","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":6},{"id":"GO:0071657","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0031032","count":5},{"id":"GO:2000637","count":5}]},{"hash":"14594588054347430","title":"Epigenetic Transcriptional Repression","description":"These proteins revolve around epigenetic control of gene expression, highlighted by negative regulation of RNA Pol II transcription, chromatin remodeling, and DNA methylation\u2013dependent heterochromatin formation, plus histone modifications (H3K9 methylation, acetylation). The inclusion of development-related terms (embryonic development, germ-line stem cell division) suggests a role in epigenetic regulation during development. Overall, the cluster represents transcriptional repression through chromatin and DNA methylation mechanisms.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0043044","count":3},{"id":"GO:0006346","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0051567","count":2}]},{"hash":"610359739519572548","title":"Nervous system and skeletal muscle development","description":"This cluster centers on developmental processes shaping nervous system connectivity (corticospinal axon guidance, corpus callosum development) and skeletal muscle formation (somite specification, skeletal muscle tissue growth), with supporting signals such as acetylcholine receptor pathways and thyroid hormone involvement, plus anti-apoptotic regulation during development. The overarching theme is neuromuscular development and patterning, despite a few terms that touch on angiogenesis or anticoagulant response.","confidence":"Medium","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0048630","count":4},{"id":"GO:2000270","count":4},{"id":"GO:0021972","count":4},{"id":"GO:0006590","count":4},{"id":"GO:0022038","count":4}]},{"hash":"928744705808239487","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0010738","count":2},{"id":"GO:0006402","count":1},{"id":"GO:0044830","count":1},{"id":"GO:0045716","count":1}]},{"hash":"130635480666735135","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901969","count":2},{"id":"GO:1901972","count":2},{"id":"GO:0006039","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0000902","count":2}]},{"hash":"1547832796996584349","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006402","count":3},{"id":"GO:0044830","count":3},{"id":"GO:0045716","count":3},{"id":"GO:0090503","count":3},{"id":"GO:2000637","count":3}]},{"hash":"342227085610127136","title":"Developmental Transcriptional Regulation and Morphogenesis","description":"This cluster shows a strong emphasis on transcription by RNA polymerase II and multiple development/morphogenesis terms (e.g., salivary gland development, outflow tract morphogenesis, segmental identity specification, olfactory bulb development), suggesting the proteins collectively participate in regulating gene expression during developmental processes and tissue formation. Some terms like circadian rhythm or ER stress\u2013related signaling are broader or context-dependent, but the core signal points to developmental transcriptional control. ","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":4},{"id":"GO:0060691","count":3},{"id":"GO:0003151","count":3},{"id":"GO:0007381","count":3},{"id":"GO:0070059","count":3}]},{"hash":"1612656920179697334","title":"TNF-Driven Innate Immune Signaling and Ubiquitination","description":"The cluster centers on TNF-mediated signaling and innate immune response, with strong representation of ubiquitin-dependent processes (ubiquitination, ERAD) and transcriptional regulation. This suggests a theme where TNF signaling activates immune responses and induces transcriptional changes, moderated by ubiquitin-mediated protein turnover. Some developmental terms appear but do not define the core function of the cluster.","confidence":"Medium","size":6,"edges":8,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006355","count":2}]},{"hash":"1202399579668968586","title":"TLR signaling and innate immune activation","description":"The top GO terms are centered on Toll-like receptor signaling (TLR2/3/9) with downstream NF-kappaB involvement, along with related processes such as IL-18 production, MHC class I biosynthesis, interferon signaling, and actin cytoskeleton remodeling. This suggests a coherent cluster of proteins coordinating innate immune sensing, transcriptional activation, and antigen presentation, with cytoskeletal changes supporting signaling and trafficking.","confidence":"High","size":6,"edges":8,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034162","count":3},{"id":"GO:0034138","count":3},{"id":"GO:0034134","count":3},{"id":"GO:0032088","count":2},{"id":"GO:0032741","count":2}]},{"hash":"1231170713787651722","title":"MAPK/JNK signaling and cell migration","description":"These proteins are enriched for GO terms involving negative regulation of the JNK cascade, peptidyl-threonine phosphorylation, Rho-mediated signaling, and cell migration, pointing to coordinated MAPK-like pathway regulation and cytoskeletal remodeling that drive cell movement. Although some terms touch on heart development, hyaluronan metabolism, and synapse localization, the core theme appears to be signaling controls that govern motility and tissue remodeling. Confidence: Medium","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046329","count":2},{"id":"GO:0018107","count":2},{"id":"GO:0098761","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0008285","count":2}]},{"hash":"196092992207941903","title":"Glutamatergic GPCR Synaptic Signaling","description":"The cluster is dominated by GO terms for G protein-coupled receptor signaling, PLC activation, calcium regulation, and specifically regulation of glutamatergic synaptic transmission, pointing to GPCR-driven signaling at excitatory synapses; terms related to visual perception and electrical stimuli further support a neuronal/visual signaling context. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":6},{"id":"GO:0000186","count":6},{"id":"GO:0030818","count":5},{"id":"GO:0090280","count":5},{"id":"GO:0007206","count":5}]},{"hash":"578157232015659152","title":"Developmental transcription regulation and proteostasis","description":"This cluster combines GO terms for transcriptional regulation (RNA Pol II\u2013mediated transcription initiation, transcription regulation) with developmental processes (intestinal epithelial differentiation, heart development, chaeta morphogenesis, stem cell proliferation) and proteostasis (deubiquitination, proteasomal protein catabolic process) plus a dexamethasone response. The common theme appears to be control of gene expression during development, modulated by ubiquitin-proteasome\u2013related turnover and hormone-responsive signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0060575","count":2},{"id":"GO:0007507","count":1},{"id":"GO:0006352","count":1},{"id":"GO:0071549","count":1}]},{"hash":"1711323785095259492","title":"Vascular smooth muscle signaling and calcium regulation","description":"The top terms cluster around cardiovascular function and smooth muscle biology: regulation of cardiac conduction and vasodilation point to control of heart rhythm and vascular tone, while positive regulation of cytosolic calcium concentration reinforces calcium-mediated contraction. Additional terms on smooth muscle cell migration, fibrinolysis, and MAPK signaling suggest vascular remodeling and hemostasis contexts, with Wnt pathway regulation indicating broader signaling control. Together, these points support a cohesive theme of vascular smooth muscle signaling and calcium regulation.","confidence":"High","size":6,"edges":10,"triangles":7,"max_degree":4,"top_function":"protein maturation","top_go_terms":[{"id":"GO:1903779","count":5},{"id":"GO:0001300","count":5},{"id":"GO:0042311","count":4},{"id":"GO:0007204","count":4},{"id":"GO:2000098","count":4}]},{"hash":"572714553588716279","title":"Unknown","description":"The GO terms are very heterogeneous, with no single dominant function tying the proteins together. Terms span cell migration, GTPase activity regulation, mechanosensing, ubiquitination, apoptosis regulation, differentiation, and transport, suggesting a broad set of unrelated cellular processes rather than a cohesive cluster function.","confidence":"","size":6,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0015991","count":2},{"id":"GO:0060769","count":2}]},{"hash":"2296543696320439821","title":"Unknown","description":"The terms span immune signaling (complement activation), cardiovascular signaling (natriuretic peptide\u2013related regulation of blood pressure), lipid and fatty acid biosynthesis, fungal cell wall synthesis, iron handling (iron-sulfur cluster assembly and iron sequestration), and neuronal ER stress regulation, with little apparent overlap. This suggests no single cohesive function for the cluster, and the mix may reflect heterogeneous or cross-species annotations rather than a unified protein group.","confidence":"","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003050","count":2},{"id":"GO:0006958","count":2},{"id":"GO:1902321","count":1},{"id":"GO:0042759","count":1},{"id":"GO:0070880","count":1}]},{"hash":"963128830765610655","title":"Autophagosome Maturation and Transport Regulation","description":"The strongest signal is autophagosome maturation (GO:0097352), suggesting an autophagy-related cluster. Several terms point to regulation of transporter activity and calcium-dependent ATPases, implying a link between membrane transport/ion balance and autophagic processes. Other terms are broader regulatory activities, indicating the cluster centers on autophagy with associated membrane transport regulation rather than a single precise function.","confidence":"Medium","size":6,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":5},{"id":"GO:0010922","count":1},{"id":"GO:1905789","count":1},{"id":"GO:1903611","count":1},{"id":"GO:1901896","count":1}]},{"hash":"1247506191940084826","title":"Neural signaling and vesicle trafficking","description":"The GO terms point to neural and electrophysiological signaling (nervous system process, glutamate reuptake, cardiac action potential components, glucose-triggered signaling) alongside vesicle-related processes (pigment granule dispersal, amelogenesis, and linked transport). This suggests a cluster of proteins involved in membrane transport and vesicle trafficking that underpins signaling and excitability in neural and muscular contexts.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:1903238","count":2},{"id":"GO:0097186","count":2},{"id":"GO:0015693","count":2},{"id":"GO:0098914","count":2}]},{"hash":"1173946070905288445","title":"Dopaminergic and Neuropeptide Signaling in Nervous System","description":"The cluster is dominated by GO terms related to neural signaling and dopaminergic pathways (synaptic transmission, dopaminergic; neuropeptide signaling; regulation of dopamine receptor signaling) and related nervous-system features (enteric nervous system development, grooming behavior, pain perception, astrocyte chemotaxis). A few terms concern non-neural processes, suggesting some pleiotropy, but the strongest signal points to dopamine/neuropeptide\u2013driven neural signaling and behavior.","confidence":"Medium","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":6},{"id":"GO:0072224","count":6},{"id":"GO:0060160","count":6},{"id":"GO:0048484","count":6},{"id":"GO:2000458","count":6}]},{"hash":"575861866279476874","title":"Multisubstrate membrane transporters","description":"These proteins are linked by GO terms for transmembrane transport of a wide range of substrates (ions, sugars, xenobiotics, neurotransmitters, etc.), including neurotransmitter loading into synaptic vesicles. The shared theme is membrane transport activity across diverse substrates, suggesting a cluster of transporter proteins with broad or varied substrate specificity.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0015751","count":2},{"id":"GO:0015739","count":2}]},{"hash":"540529937808769511","title":"Adaptive Immune Differentiation and Ubiquitination Regulation","description":"The GO terms cluster around adaptive immunity\u2014memory T cell differentiation, dendritic cell differentiation, and germinal center formation\u2014suggesting a role in shaping immune responses. Two terms involve ubiquitin pathways (negative regulation of ubiquitination and ubiquitin-dependent protein catabolic process), implying links to protein turnover in signaling. While some terms are unrelated (circadian rhythm, muscle/organ development), the immune differentiation and ubiquitination connection best explains the cluster's core function.","confidence":"Medium","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":3},{"id":"GO:0043380","count":2},{"id":"GO:0031397","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0042787","count":2}]},{"hash":"335415736641234676","title":"Unknown","description":"The GO terms are highly diverse and cover signal transduction (STAT), nuclear localization, mitochondria, plasmid maintenance, sarcomere/cytoskeleton organization, proteolysis/autoprocessing, and developmental terms. There is no single cohesive function tying these proteins together, suggesting either a mixed set or annotation noise rather than a shared pathway.","confidence":"","size":6,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042517","count":1},{"id":"GO:0051457","count":1},{"id":"GO:0048311","count":1},{"id":"GO:0006276","count":1},{"id":"GO:0045214","count":1}]},{"hash":"668411344473588669","title":"Cilia and Flagella Assembly and Movement","description":"The GO terms cluster around cilium/flagellum biogenesis and motility, including axoneme assembly, various forms of cilium movement (epithelial and sperm), and flagellated sperm motility, as well as tubulin post-translational modifications (polyglutamylation/polyglycylation) that modulate microtubule-based motility. One term about SSU-rRNA maturation is an outlier, but the dominant theme supports ciliary/flagellar assembly and movement. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":1},{"id":"GO:0018094","count":1},{"id":"GO:0051013","count":1},{"id":"GO:0030516","count":1},{"id":"GO:0007288","count":1}]},{"hash":"1542290053585147246","title":"Thiamine and MoCo Cofactor Biosynthesis","description":"The top GO terms point to biosynthetic processes for cofactors, especially thiamine (GO:0009228, GO:0009229) and the molybdenum cofactor (MoCo) biosynthesis (GO:0006777). While other terms touch on autophagy regulation and cell adhesion/angiogenesis, the clearest shared theme is cofactor assembly, suggesting this label best captures the cluster\u2019s common function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016239","count":1},{"id":"GO:0061635","count":1},{"id":"GO:0018315","count":1},{"id":"GO:0006777","count":1},{"id":"GO:0009229","count":1}]},{"hash":"490530439994365038","title":"Neural and Eye Development","description":"This cluster is dominated by neural and sensory organ development terms: brain segmentation, rhombomere 5 development, and dopaminergic neuron differentiation, along with eye morphogenesis terms (camera-type eye development, embryonic eye morphogenesis). The presence of transcription by RNA polymerase II supports a gene-regulatory program underlying neural and eye formation. While other organ development terms (pancreas, lung) appear, the strongest signal centers on neural patterning and eye development, justifying this label. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0035284","count":4},{"id":"GO:0021571","count":4},{"id":"GO:0071542","count":3},{"id":"GO:0031018","count":3}]},{"hash":"1770426029045000810","title":"Dopaminergic Neuronal Signaling and Pain Processing","description":"These proteins cluster around nervous system signaling, especially dopamine-related pathways. Terms like dopaminergic synaptic transmission, neuropeptide signaling, and sensory perception of pain, along with grooming behavior and astrocyte chemotaxis regulation, point to dopamine-mediated neurotransmission and neural modulation. A couple of unrelated terms (saliva secretion, metanephric glomerulus development) are present but do not override the dominant neuronal signaling theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":6},{"id":"GO:0072224","count":6},{"id":"GO:0060160","count":6},{"id":"GO:0048484","count":6},{"id":"GO:2000458","count":6}]},{"hash":"1532299133032096043","title":"Retinal GPCR Signaling and Visual Perception","description":"I name this cluster Retinal GPCR Signaling and Visual Perception because the predominant GO terms cluster around G protein-coupled receptor signaling, PLC activation, and glutamatergic synaptic transmission, along with a term for light-stimulus detection. This combination points to photoreceptor-related signaling and vision-related neural communication, with electron transport chain reflecting the energy requirements of active neurons.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030818","count":5},{"id":"GO:0090280","count":5},{"id":"GO:0007206","count":5},{"id":"GO:0022900","count":5},{"id":"GO:0050908","count":5}]},{"hash":"478384341212852506","title":"Ubiquitin-mediated apoptosis signaling","description":"The cluster is characterized by protein ubiquitination (autoubiquitination and K63-linked ubiquitination) and regulation of apoptotic processes, with supporting links to JNK cascade regulation, suggesting a module of ubiquitin-dependent signaling that modulates apoptosis and stress responses; several terms are obsolete or tangential (e.g., V(D)J recombination, neural development), but the core pattern supports ubiquitin-mediated regulation of cell death pathways.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":5},{"id":"GO:0090073","count":5},{"id":"GO:0033151","count":5},{"id":"GO:1903762","count":5},{"id":"GO:0070534","count":5}]},{"hash":"1797854895267516859","title":"Unknown","description":"The top GO terms span transcription and stress responses but also include various developmental and immune-related signals, with no clear single function tying all five proteins together; thus no concise, representative label can be determined.","confidence":"","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0036499","count":3},{"id":"GO:0072049","count":2},{"id":"GO:0061382","count":2}]},{"hash":"631611096220438472","title":"Embryonic Skeletal and Neural Morphogenesis","description":"The GO terms point to embryonic development and tissue morphogenesis, with clear emphasis on skeletal formation (osteoblast differentiation, cranial skeleton morphogenesis) and neural/early embryonic patterning (gastrulation, EMT, neural lineage development). A few terms are more peripheral (cholesterol response, insect histoblast), but the dominant theme is embryonic morphogenesis and bone formation.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045669","count":2},{"id":"GO:0010991","count":1},{"id":"GO:0072520","count":1},{"id":"GO:0007488","count":1},{"id":"GO:0070723","count":1}]},{"hash":"178333260153166300","title":"Unknown","description":"The GO terms are highly diverse, spanning digestion, neuromuscular posture control, metabolic signaling, immune signaling, wound healing, development, cytolysis, zinc homeostasis, and lipid/phospholipid remodeling. There isn\u2019t a unifying function or pathway that ties these terms together, so a coherent simple label isn\u2019t supported.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007586","count":2},{"id":"GO:0050884","count":2},{"id":"GO:0033211","count":1},{"id":"GO:1901223","count":1},{"id":"GO:0061042","count":1}]},{"hash":"484361844606416698","title":"ER-Golgi vesicle transport and SNARE assembly","description":"These proteins are enriched for ER-to-Golgi transport, SNARE complex assembly, and general protein trafficking, with additional links to Golgi ribbon formation and autophagy. A few terms also touch on dendrite development or hindgut contraction, likely reflecting broader trafficking roles in neurons and developing tissues, but the dominant theme is vesicular transport and Golgi organization.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0016358","count":3},{"id":"GO:0045212","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006914","count":3}]},{"hash":"1983632402730398023","title":"Phytochelatin biosynthesis","description":"The cluster is dominated by the GO term for phytochelatin biosynthesis, indicating a core link to metal detox via phytochelatin production. The presence of proteolysis and autophagy-regulation terms alongside suggests these proteins also participate in stress response and protein quality control during detoxification, making a cohesive theme around phytochelatin-mediated metal detox and cellular proteostasis.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046938","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0043085","count":3},{"id":"GO:1904715","count":3},{"id":"GO:0018279","count":1}]},{"hash":"1512901525753253833","title":"Tissue morphogenesis and immune cell adhesion","description":"The cluster shows proteins linked to developmental processes (sprouting angiogenesis, outflow tract morphogenesis, optic vesicle formation) and cell adhesion, along with immune-related terms (response to lipopolysaccharide, leukocyte tethering/rolling). This points to a theme of morphological development with coordinated immune/vascular cell interactions, rather than a single specific pathway. ","confidence":"Medium","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":3},{"id":"GO:0032496","count":2},{"id":"GO:0044179","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0097186","count":2}]},{"hash":"1990593318515984866","title":"Steroid Biosynthesis and Metabolism","description":"The top GO terms cluster around steroid hormone biosynthesis and related cholesterol-derived pathways (ecdysone, aldosterone, bile acids, brassinosteroids) and P450-mediated hydroxylation, pointing to a shared role in steroid production/metabolism across species. Some developmental terms may reflect downstream hormonal effects rather than a single process.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006697","count":2},{"id":"GO:0097267","count":2},{"id":"GO:0032342","count":2},{"id":"GO:0071615","count":2},{"id":"GO:0006699","count":2}]},{"hash":"55486730176878480","title":"Membrane Lipid Remodeling and Cell Envelope Biosynthesis","description":"The cluster\u2019s top GO terms are dominated by lipid remodeling (cardiolipin and phosphatidylcholine acyl-chain remodeling) and surface/envelope biosynthesis (cell wall and capsule polysaccharide biosynthesis, mycolate layer assembly, and related lipid-linked sugar biosynthesis). While a couple of terms (brain development, immunoglobulin production) are unrelated, the prevailing functions point to membrane composition and cell envelope assembly as the shared theme. Therefore, a membrane lipid remodeling and cell envelope biosynthesis label is most representative.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0035965","count":2},{"id":"GO:0006663","count":2},{"id":"GO:0036151","count":2},{"id":"GO:0036108","count":1}]},{"hash":"1821567763399346045","title":"Signaling regulators and cytoskeletal remodeling","description":"The top GO terms point to modulation across multiple signaling pathways (insulin receptor signaling, T cell receptor signaling) and stress responses (ER stress/UPR, PERK), together with cytoskeletal dynamics (actin polymerization and actin cytoskeleton). The presence of several negative regulators suggests these proteins act as modulators that coordinate signaling output with cytoskeletal remodeling and stress responses, rather than a single, isolated pathway. This justifies labeling the cluster as regulators of diverse signaling with links to cytoskeletal dynamics.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008286","count":5},{"id":"GO:0090557","count":5},{"id":"GO:1902237","count":5},{"id":"GO:0034260","count":5},{"id":"GO:1903898","count":5}]},{"hash":"877091538600766870","title":"Retroviral DNA integration and latency","description":"This cluster is dominated by terms such as establishment of integrated proviral latency, DNA integration, and negative regulation of viral genome replication, pointing to proteins involved in retroviral integration and latency. Some spliceosome and mitotic membrane dynamics terms appear but at low frequency, likely representing shared host factors exploited during infection rather than core functions.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0007077","count":2},{"id":"GO:0045071","count":2},{"id":"GO:0030717","count":2}]},{"hash":"1844799796088204701","title":"Nuclear RNA Processing and Chromatin Regulation","description":"The cluster is enriched for nuclear RNA processing steps\u2014spliceosomal assembly, SSU-rRNA maturation, RNA polymerase II transcription termination, and deadenylation-dependent decapping of nuclear-transcribed mRNA\u2014as well as chromatin-related processes such as histone mRNA metabolism and pericentric heterochromatin formation; this points to a cohesive function in RNA processing coupled with chromatin maintenance, with ABA and water-deprivation terms reflecting regulatory context.","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051170","count":2},{"id":"GO:0000245","count":2},{"id":"GO:1990141","count":2},{"id":"GO:0030490","count":2},{"id":"GO:0006369","count":2}]},{"hash":"851657175416775500","title":"Immune signaling and T cell apoptosis regulation","description":"The top GO terms cluster around inflammatory signaling, especially cellular responses to interleukin-6 and interleukin-1, paired with regulation of apoptosis, including extrinsic death receptor pathways and activation-induced T cell death. This suggests the proteins collectively participate in immune/inflammatory signaling and control of T cell survival. A few terms (platelet activation, cardiac muscle calcium regulation) appear as potential peripheral associations or background noise rather than core functions of the cluster.","confidence":"Medium","size":5,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071354","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0010881","count":1},{"id":"GO:0006924","count":1}]},{"hash":"1726607326257605448","title":"Chromosome Condensation and Cohesion in Mitosis/Meiosis","description":"This cluster centers on chromosomal architecture during cell division, including mitotic chromosome condensation, sister chromatid cohesion, and cohesin loading/dynamics (with several related and obsolete terms), as well as meiotic chromosome condensation. It also encompasses DNA damage response and repair of double-strand breaks (SOS response and homologous recombination), and regulation of meiotic DSB formation, tying chromosome structure maintenance to genome stability during meiosis. A minor note is tRNA gene clustering, which may reflect broader chromatin organization rather than a core function here.","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070058","count":2},{"id":"GO:0007076","count":2},{"id":"GO:0009432","count":2},{"id":"GO:1903342","count":2},{"id":"GO:0061780","count":2}]},{"hash":"278987534697736633","title":"Centromere-Kinetochore Chromosome Segregation","description":"This cluster is enriched for mitotic and centromere-associated processes: mitotic cell cycle, kinetochore assembly, and CENP-A-containing chromatin assembly, along with replication fork processing and DNA repair, all pointing to chromosome maintenance during cell division. The presence of meiotic recombination resolution supports a DNA repair/chromosome maintenance theme that aligns with centromere/kinetochore\u2013driven segregation.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000712","count":2},{"id":"GO:0031398","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0031297","count":2},{"id":"GO:0034080","count":2}]},{"hash":"1267461635978235859","title":"Embryonic organ morphogenesis","description":"These proteins show a cohesive theme of development and organ formation, with GO terms including roof of mouth development, brain development, embryonic digit morphogenesis, neurohypophysis development, ureteric bud morphogenesis, septum development, and related pronephros size regulation. While some terms are broader (regulation of binding, behavior), the dominant signal is embryonic organ morphogenesis across multiple tissues, justifying a concise label of Embryonic organ morphogenesis.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0051098","count":2},{"id":"GO:0044708","count":2},{"id":"GO:0021985","count":2},{"id":"GO:0090190","count":2}]},{"hash":"1398769025814168092","title":"Metanephric tubule morphogenesis","description":"This cluster is dominated by GO terms related to metanephric kidney development, including distal and proximal tubule morphogenesis and development, indicating a strong theme of nephron/tubule morphogenesis. A few immune-related terms appear (e.g., Fc-gamma receptor signaling, basophil activation, leukocyte tethering), which may reflect multifunctional proteins or annotation noise, but do not override the clear renal development signal.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0072287","count":4},{"id":"GO:0038094","count":4},{"id":"GO:0071226","count":4},{"id":"GO:0036303","count":4},{"id":"GO:0090403","count":4}]},{"hash":"1652096250194175995","title":"Coagulation and extracellular matrix remodeling","description":"This cluster centers on hemostasis and ECM interactions, with terms for blood coagulation, fibrinolysis, collagen fibril organization, and cell-matrix/heterotypic adhesion, plus proteoglycan biosynthesis. The inclusion of IL-1\u2013related signaling and vasoconstriction suggests integration with inflammation and vascular remodeling. Overall, a coherent theme of coagulation coupled with extracellular matrix dynamics and inflammatory response.","confidence":"Medium","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050928","count":2},{"id":"GO:0045907","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0030210","count":2}]},{"hash":"1064808781872835185","title":"MAPK-driven stress signaling","description":"The top GO terms cluster around ERK1/ERK2 cascade and stress-related responses (intrinsic apoptotic signaling from ER stress, cellular responses to PMA and cadmium). This points to a core MAPK signaling axis governing stress responses, with microtubule localization supporting associated cytoskeletal changes; the developmental terms likely reflect downstream roles of MAPK signaling in forebrain and skeletal development. ","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070059","count":3},{"id":"GO:1903343","count":3},{"id":"GO:1904628","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0001501","count":3}]},{"hash":"319346987692183763","title":"Ubiquitin-Dependent Proteolysis and Signaling","description":"The cluster is dominated by ubiquitination-related terms (autoubiquitination, ubiquitin-dependent ERAD, and proteolysis) with links to signaling pathways such as TNF, JNK, and RIG-I, indicating a cohesive module of ubiquitin-mediated proteolysis and regulation of stress/immune signaling.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0033209","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0090073","count":4}]},{"hash":"134132643548652198","title":"Angiogenesis and Development","description":"GO terms strongly point to blood vessel formation and broader developmental processes (angiogenesis, positive regulation of angiogenesis, multicellular organism development, cerebral cortex development). While there are scattered signals of stress-related apoptosis and DNA damage signaling, the dominant theme is vascular development within organismal development, justifying the label.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0032092","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0045766","count":2},{"id":"GO:2000811","count":1}]},{"hash":"840884742091108374","title":"Lymphocyte activation and actin-driven migration","description":"This cluster centers on immune cell activation signals (IL-7 response, T cell proliferation, B cell differentiation) and cytoskeletal dynamics (actin binding, cell migration, adhesion-dependent spreading), with caveolin-mediated endocytosis indicating membrane trafficking work in lymphocytes. The combination points to a cohesive module of lymphocyte activation coupled with motility and cytoskeletal remodeling.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0072584","count":5},{"id":"GO:0098761","count":5},{"id":"GO:0002333","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0050798","count":5}]},{"hash":"2152810347618707880","title":"Unknown","description":"The top GO terms span several unrelated biological areas (mRNA processing, cell migration, telomere maintenance/capping, muscle stretch response, adipocyte differentiation, and sterol biosynthesis) with no clear single function tying the cluster together; several terms are obsolete or appear incidental, suggesting no cohesive annotation for this group.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":4},{"id":"GO:0016477","count":3},{"id":"GO:2001275","count":3},{"id":"GO:1904355","count":3},{"id":"GO:0035994","count":3}]},{"hash":"824572670090684122","title":"Sensory Epithelium Morphogenesis and Cell Cycle Regulation","description":"The top GO terms point to development and structure of sensory epithelia (eye morphogenesis, brush border assembly, sensory perception of sound, equilibrioception) alongside epithelial proliferation (keratinocyte proliferation) and core cell-cycle regulation, plus responses to mechanical stimuli, ubiquitination, and apoptosis. This pattern suggests a theme of morphogenesis and maintenance of sensory epithelial tissues with intertwined cell-cycle control and stress responses, rather than a single narrow function.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":2},{"id":"GO:1904970","count":2},{"id":"GO:0048593","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0016567","count":2}]},{"hash":"371948365085255138","title":"Cytoplasmic Translation and tRNA Charging","description":"The cluster is dominated by terms tied to protein synthesis, including cytoplasmic translation and tRNA aminoacylation (threonyl-tRNA and mitochondrial alanyl-tRNA). While a few other GO terms (cell migration, GTPase activation) appear, the strongest signal points to translation machinery and tRNA charging, suggesting this cluster centers on protein synthesis. ","confidence":"Medium","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0015966","count":2}]},{"hash":"1671850445462349323","title":"Insulin signaling and metabolic regulation","description":"The cluster is dominated by GO terms connected to insulin receptor signaling, PI3K/AKT pathway activity, and responses to insulin that influence glucose import and related phosphorylation events, indicating a core theme of insulin-driven metabolic signaling. Some terms also reflect broader signaling regulation and tissue remodeling links (e.g., JNK regulation, heart development), but the strongest signal centers on insulin signaling and metabolism.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046329","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0097011","count":5},{"id":"GO:0030212","count":5},{"id":"GO:0008286","count":5}]},{"hash":"2145991435170097271","title":"Endothelial Activation and Angiogenesis","description":"The terms cluster around endothelial biology and vascular development: endothelial cell activation, differentiation, and proliferation in sprouting angiogenesis, as well as cell-matrix adhesion and coagulation. While a few terms (ureteric bud development, sensory perception of sound) seem unrelated, the predominant theme is endothelial- and blood vessel\u2013related processes, suggesting this protein group is tied to vascular activation and angiogenesis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042118","count":1},{"id":"GO:0030514","count":1},{"id":"GO:0001657","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0007160","count":1}]},{"hash":"2009532435371601364","title":"Isoprenoid and sterol biosynthesis","description":"The top GO terms point strongly to terpenoid/isoprenoid production (farnesyl, geranyl, and geranylgeranyl diphosphate biosynthesis, monoterpene biosynthesis) and cholesterol/quinone biosynthesis, indicating enzymes involved in prenylation and sterol/isoprenoid pathways. Other terms like protein transport or specific methylations appear tangential and do not define the cluster\u2019s core function. ","confidence":"High","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901663","count":3},{"id":"GO:0051290","count":3},{"id":"GO:0006695","count":3},{"id":"GO:0045337","count":3},{"id":"GO:0033384","count":3}]},{"hash":"1876065506492490352","title":"Unknown","description":"The top GO terms are spread across neural development (globus pallidus development, optic nerve organization), sensory perception, magnesium response, and cardiac electrophysiology (atrial repolarization, heart rate regulation). There is no clear, single biological process or function tying all terms together for these five proteins, so a coherent cluster label cannot be inferred.","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":1},{"id":"GO:0021759","count":1},{"id":"GO:0060372","count":1},{"id":"GO:0086091","count":1},{"id":"GO:1900454","count":1}]},{"hash":"588063198561059965","title":"CNS Axon Guidance and Synapse Assembly","description":"This cluster is dominated by nervous-system development terms: corpus callosum development, CNS projection neuron axonogenesis, axon guidance for motor and retinal ganglion cells, and positive regulation of synapse assembly, plus visual perception. The shared theme points to neural connectivity formation and visual pathway development; a couple of immune signaling terms appear less central. ","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0021952","count":2},{"id":"GO:0061368","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1636650519300240124","title":"Cellular stress response and neural development","description":"The cluster features GO terms tied to innate immune response, cellular responses to toxins (cadmium, toxic substances), and various developmental processes in the cerebellum and retinal rods, along with metabolic activities like fatty acid oxidation and cholesterol biosynthesis, plus hormone-stimulated responses. This suggests proteins involved in managing cellular stress while participating in neural development programs, though the set is small and somewhat heterogeneous. ","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0071375","count":2},{"id":"GO:0071372","count":2}]},{"hash":"1562375807920861056","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006189","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0042853","count":2},{"id":"GO:0015992","count":2},{"id":"GO:1902600","count":2}]},{"hash":"1428674136252279529","title":"Glutathione-Mediated Redox Detox","description":"The cluster is enriched for redox-related processes: glutathione metabolism, glutathionylation, L-ascorbic acid metabolism, and cellular oxidant detoxification, plus a response to arsenic-containing substances. These point to antioxidant defense and maintenance of redox balance as core themes. Additional terms like nucleotide-excision repair and aromatic amino acid metabolism appear but seem secondary to the dominant detox/redox signal, suggesting a primary linkage to redox homeostasis with some ancillary metabolic roles.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019852","count":4},{"id":"GO:0006289","count":4},{"id":"GO:0010731","count":4},{"id":"GO:0006749","count":4},{"id":"GO:0009072","count":4}]},{"hash":"1718358542889268157","title":"Embryonic organogenesis and cell migration","description":"GO terms cluster around development and organ formation, with pancreas morphogenesis, digestive system development, midbrain development, and post-embryonic development indicating organogenesis across tissues. The inclusion of migration terms (smooth muscle cell migration, leukocyte migration) suggests cellular movement during development or tissue remodeling. A few terms on transcription regulation and vascular processes are present but do not dominate, so the overarching theme is developmental morphogenesis.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0014909","count":3},{"id":"GO:0002523","count":3},{"id":"GO:0061113","count":2},{"id":"GO:0009791","count":2},{"id":"GO:0035264","count":2}]},{"hash":"1859827302434945270","title":"Lens and Hair Follicle Development","description":"This cluster is dominated by GO terms for lens fiber cell development and hair follicle morphogenesis, suggesting a common theme of ectoderm-derived organogenesis (eye and skin appendages). Other terms touch on broader developmental processes and signaling, but the strongest and most specific connection is lens and hair follicle formation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070307","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0046619","count":1},{"id":"GO:0002053","count":1},{"id":"GO:0032000","count":1}]},{"hash":"231174082105402122","title":"Unknown","description":"The GO terms are very diverse, ranging from oxidative stress response and immune signaling to brain development, metabolism, cell communication, and muscle structure. There is no clear, single biological function or pathway tying all terms together, suggesting heterogeneous roles or unrelated annotations. Therefore a specific, cohesive label is not defensible.","confidence":"","size":5,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":2},{"id":"GO:0021756","count":2},{"id":"GO:0009228","count":2},{"id":"GO:1904783","count":1},{"id":"GO:1990314","count":1}]},{"hash":"496131578450918379","title":"Ciliary/Flagellar Axoneme Assembly and Motility","description":"The terms are dominated by cilium/flagellum-related processes: axoneme assembly, cilium movement, and sperm motility, plus tubulin post-translational modifications (polyglutamylation, polyglycylation) and microtubule severing, all pointing to the assembly and movement of motile cilia/flagella and their microtubule regulation.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016540","count":2},{"id":"GO:0018094","count":1},{"id":"GO:0051013","count":1},{"id":"GO:0030516","count":1},{"id":"GO:0007288","count":1}]},{"hash":"656473661632781163","title":"Zinc Transport and Homeostasis","description":"The top GO terms are dominated by zinc-related transport and homeostasis\u2014zinc ion import across the plasma membrane (GO:0006830/GO:0044749/GO:0006831), detoxification of zinc ion, intracellular zinc ion homeostasis, and cellular response to zinc ion starvation\u2014pointing to proteins that mediate zinc uptake, balance intracellular zinc, and detoxify excess zinc. The presence of cadmium ion transmembrane transport suggests broader metal-transport capability, while limb development and mesenchymal proliferation terms appear incidental. Overall, the cluster best represents zinc transport and homeostasis.","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006830","count":3},{"id":"GO:1903615","count":3},{"id":"GO:0044749","count":3},{"id":"GO:0006831","count":3},{"id":"GO:0010312","count":3}]},{"hash":"1973807463698530640","title":"Unknown","description":"The terms span sensory, developmental, reproductive, and tissue-adhesion processes with no single cohesive function tying all proteins together, including ear/earbone development, heart morphogenesis, fertilization-related events, and insect cuticle attachment.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0007160","count":2},{"id":"GO:0035889","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0042102","count":1}]},{"hash":"1592148468250323435","title":"Immune Activation and Antigen Presentation","description":"This cluster is dominated by terms tied to adaptive immunity and antigen presentation (MHC I/II pathways, TAP-dependent presentation, T cell proliferation and costimulation, and overall adaptive immune response), with accompanying innate neutrophil functions (degranulation and clearance). A few terms relate to xenobiotic response or spermatid development, which are less coherent with the primary theme, but the core signal points to immune activation and antigen processing/presentation.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043312","count":5},{"id":"GO:0042102","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0097350","count":4},{"id":"GO:0045404","count":4}]},{"hash":"1047197560442323061","title":"Golgi-ER Vesicle Trafficking","description":"The top GO terms cluster around intracellular transport between the ER and Golgi, SNARE complex disassembly, and proteins retained in the Golgi, plus mentions of dense-core vesicle transport. This points to a coherent theme of vesicle trafficking and Golgi/secretory pathway function, with a few terms related to other core processes that may reflect broad annotations in a small cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0035494","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0090263","count":2}]},{"hash":"27918044969302465","title":"Cardiac Muscle Development and cAMP Signaling","description":"The cluster is dominated by GO terms related to muscle structure and growth, such as sarcomere organization and cardiac muscle cell proliferation, suggesting a muscle/heart development theme. Additionally, regulation of cAMP/PKA signaling (adenylate cyclase activity) ties into signaling pathways that modulate muscle function. Some terms (reproduction or immune-related) appear less central and may be noise, but the strongest signal centers on cardiac muscle development and associated signaling. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0007339","count":1},{"id":"GO:0060038","count":1},{"id":"GO:0097332","count":1},{"id":"GO:2000480","count":1}]},{"hash":"1848273743359702704","title":"Muscle development and cell adhesion","description":"The cluster shows enrichment for terms tied to muscle formation and interaction with the extracellular matrix, including myoblast fusion involved in skeletal muscle regeneration, neuromuscular junction development, tissue regeneration, and positive regulation of cell-matrix adhesion. While there are also broad vesicle trafficking terms (protein transport, ER-to-Golgi transport) that are common in many cells, the muscle-specific terms dominate, supporting a theme of muscle development and adhesion-related processes.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001954","count":2},{"id":"GO:0014905","count":1},{"id":"GO:0045026","count":1},{"id":"GO:0042147","count":1},{"id":"GO:0015031","count":1}]},{"hash":"2286096322881943499","title":"Inflammation and oxidative stress response","description":"The top GO terms point to innate immune/inflammatory processes (response to lipopolysaccharide; leukotriene production in inflammatory response) along with redox-related processes (cellular oxidant detoxification; response to lipid hydroperoxide). Calcium signaling and enzyme activity regulation also align with activation and signaling in immune contexts. Together these terms suggest a cluster centered on inflammatory signaling with concurrent redox regulation, hence the label. ","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043085","count":1},{"id":"GO:0032496","count":1},{"id":"GO:0032526","count":1},{"id":"GO:0014070","count":1},{"id":"GO:0002540","count":1}]},{"hash":"1210656105022191468","title":"Steroid and bile acid metabolism","description":"This cluster centers on metabolism of lipid-derived compounds: progesterone, bile acids, and retinoic acid regulation, pointing to steroid and bile acid metabolic processes. Additional terms like glutathione biosynthesis and JAK-STAT signaling may reflect broader regulatory and detoxification roles in hormone-responsive tissues, while maternal process hints at reproductive biology. Overall, the strongest shared theme is metabolism of steroid and bile acid derivatives.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001894","count":4},{"id":"GO:0060135","count":4},{"id":"GO:0006699","count":4},{"id":"GO:1900053","count":4},{"id":"GO:0046427","count":4}]},{"hash":"706630782593568196","title":"Inflammation and Oxidative Stress Response","description":"The top GO terms center on inflammatory signaling (response to lipopolysaccharide, leukotriene production in inflammatory response, retinoic acid response) and redox-related processes (cellular oxidant detoxification, lipid hydroperoxide response, calcium signaling). Although the proteins have no reported edges here, the recurring themes point to immune/inflammatory and oxidative stress regulation as the cluster\u2019s shared function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043085","count":1},{"id":"GO:0032496","count":1},{"id":"GO:0032526","count":1},{"id":"GO:0014070","count":1},{"id":"GO:0002540","count":1}]},{"hash":"1404759038295786544","title":"Steroid biosynthesis and hormone metabolism","description":"Dominant GO terms are steroid biosynthesis pathways (ecdysone, aldosterone, brassinosteroid) and omega-hydroxylase P450 activity, indicating a cluster of proteins involved in steroid hormone production and metabolism. Some terms about development or stress responses are present but appear secondary to the steroid-related signals.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006697","count":4},{"id":"GO:0097267","count":4},{"id":"GO:0032342","count":4},{"id":"GO:0071615","count":4},{"id":"GO:0006699","count":4}]},{"hash":"1031664664319222919","title":"Lipid biosynthesis and sphingolipid metabolism","description":"This cluster is dominated by lipid-related GO terms: fatty acid response, monounsaturated fatty acid biosynthesis, sphinganine/sphingolipid metabolism, ergosterol biosynthesis, and glycosphingolipid pathways (MIPC). The presence of adipose- or gland-development terms (white fat cell differentiation, tarsal gland development) aligns with lipid storage and lipid-derived signaling in development. Overall, it points to lipid metabolism and sphingolipid biosynthesis as the core theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":2},{"id":"GO:0006667","count":1},{"id":"GO:1903699","count":1},{"id":"GO:0050872","count":1},{"id":"GO:0044130","count":1}]},{"hash":"40058610653810073","title":"Synaptic vesicle release and plasticity.","description":"The cluster is dominated by GO terms for synaptic vesicle priming, SNARE complex assembly, vesicle fusion at the presynaptic membrane, and short-term synaptic potentiation, plus regulation of synapse assembly and plasticity, indicating involvement in the neurotransmitter release machinery and its rapid modulation. Some terms like histamine secretion and sleep are peripheral modifiers of neuronal signaling but do not contradict the core theme. Overall, this cluster reflects a synaptic release/plasticity module.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016082","count":2},{"id":"GO:0031629","count":1},{"id":"GO:0002553","count":1},{"id":"GO:0030431","count":1},{"id":"GO:0099590","count":1}]},{"hash":"775386905934300335","title":"Neuromuscular development and synapse formation","description":"The cluster is centered on neural connectivity and neuromuscular development, with GO terms such as neuromuscular junction development, skeletal muscle fiber development, regulation of axon diameter, and excitatory postsynaptic potential, plus myelination indicating broader neural maturation. Additional terms about cell-matrix adhesion and apoptotic processes may reflect tissue remodeling during development, but the core theme ties to how neurons connect to muscles and form functional synapses. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001954","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0042552","count":1},{"id":"GO:0010961","count":1},{"id":"GO:0070782","count":1}]},{"hash":"2186253887912752385","title":"Negative Regulation of Synaptic Plasticity","description":"The top GO terms center on decreasing long-term potentiation and dendritic spine maintenance, both key to synaptic strength and plasticity. Additional terms touch on neuronal signaling and excitability (potassium transport, tyrosine phosphorylation), supporting a neuronal, synapse-focused theme. Some terms are from other processes, but the strongest common thread is inhibition of synaptic plasticity, justifying the label.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030818","count":2},{"id":"GO:0046007","count":1},{"id":"GO:1901379","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0050731","count":1}]},{"hash":"1549958680370606673","title":"Neural and Skeletal Tissue Development","description":"The top GO terms point to development of neural tissues (central nervous system and hippocampus) alongside skeletal/connective tissue formation (skeletal system development, cartilage condensation, collagen fibril organization). A few terms indicate immune modulation, but the dominant pattern is coordinated development of nervous and skeletal systems, with connective tissue remodeling as a core theme.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901492","count":1},{"id":"GO:1900625","count":1},{"id":"GO:0007417","count":1},{"id":"GO:0043154","count":1},{"id":"GO:0001502","count":1}]},{"hash":"296863987253309087","title":"DNA repair and recombination","description":"The cluster includes several GO terms tied to DNA repair and homologous recombination, such as DNA repair (GO:0006281), DNA recombinase assembly (GO:0000730), replication fork processing (GO:1990426), replication-born double-strand break repair via sister chromatid exchange (GO:1990414), and reciprocal meiotic recombination (GO:0007131). These indicate a core function in maintaining genomic integrity during replication stress and recombination events. Some terms like viral mRNA export and mRNA processing are less central but do not override the dominant DNA damage\u2013repair/recombination theme. Therefore, this label best reflects the cluster\u2019s primary biology. ","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046784","count":1},{"id":"GO:0006397","count":1},{"id":"GO:1990426","count":1},{"id":"GO:1990414","count":1},{"id":"GO:0006281","count":1}]},{"hash":"1592235558481181863","title":"Cytokinesis and cell division","description":"Reason: The dominant GO terms cluster around cell division and cytokinesis across prokaryotes and eukaryotes (FtsZ-dependent cytokinesis, cell septum assembly, mitotic cytokinesis, spindle pole body duplication) and include cell cycle and polymerization terms, pointing to cell division machinery and its regulation. Some notes (translation regulation, mechanosensory signaling) may reflect broader or cross-species annotations, but the core signal is division-related. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000767","count":4},{"id":"GO:0043093","count":4},{"id":"GO:1905792","count":4},{"id":"GO:1905789","count":4},{"id":"GO:0051258","count":4}]},{"hash":"1842938001861597649","title":"ER protein trafficking and quality control","description":"The Top Terms include ER localization/membrane targeting, ER retrograde transport to the cytosol, and ubiquitin-dependent ERAD, pointing to an ER-centric trafficking/quality-control theme. Additional terms about endosome localization and translation-related regulation may reflect broader coordination of protein synthesis with trafficking, but the core signal is ER-associated protein handling.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045948","count":1},{"id":"GO:0048024","count":1},{"id":"GO:0046833","count":1},{"id":"GO:0010936","count":1},{"id":"GO:0036010","count":1}]},{"hash":"1151829800537155107","title":"Organ and tissue development","description":"Most terms point to development of organs and tissues (kidney and liver development; ventricular cardiac muscle tissue morphogenesis; muscle cell development; retinal rod cell development), suggesting the cluster represents genes involved in organogenesis. The other terms (regulation of mRNA processing; steroid hormone receptor complex assembly; cytokinin-activated signaling; negative regulation of arterial blood pressure) could reflect regulatory roles in development or broader signaling, but they are less cohesive. Overall, a developmental organ/tissue focus best captures the cluster.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050684","count":1},{"id":"GO:0001822","count":1},{"id":"GO:0001889","count":1},{"id":"GO:0055010","count":1},{"id":"GO:0048747","count":1}]},{"hash":"625656697184698571","title":"Nuclear protein import and NPC assembly","description":"The cluster is defined by GO terms about importing proteins into the nucleus (ribosomal protein import, NLS-bearing import) and assembling the nuclear pore complex, indicating proteins involved in nuclear transport and NPC formation. Other terms on protein regulation are ancillary.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006610","count":4},{"id":"GO:0051292","count":4},{"id":"GO:0000060","count":4},{"id":"GO:0006607","count":4},{"id":"GO:0060188","count":4}]},{"hash":"1770365725751682685","title":"Actin Cytoskeleton Remodeling and Motility","description":"The proteins cluster around actin dynamics and cell movement: actin polymerization-dependent motility, actomyosin organization, cell-matrix adhesion, and cytokinesis (cleavage furrow formation), plus dendritic spine maintenance. Ephrin signaling can drive cytoskeletal remodeling, supporting a cohesive theme of actin-driven remodeling and motility; unrelated/obsolete terms are present but don\u2019t override the main pattern.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":2},{"id":"GO:0071657","count":1},{"id":"GO:0051282","count":1},{"id":"GO:0070358","count":1},{"id":"GO:2000251","count":1}]},{"hash":"1385441667890413221","title":"Cortical development and actin cytoskeleton regulation","description":"The cluster highlights cortical/neural development terms (cerebral cortex development, corpus callosum development) and actin cytoskeleton organization, suggesting a theme of neuronal development coupled with cytoskeletal dynamics. Additional terms related to apoptosis and stress signaling likely reflect interconnected cellular stress responses rather than core functions of the cluster, but do not override the dominant cortical-development/actin pattern.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030866","count":4},{"id":"GO:2000811","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0046329","count":3},{"id":"GO:0072428","count":3}]},{"hash":"985365674822747329","title":"Developmental Signaling and Stress Responses","description":"This cluster combines terms centered on development (brain and seminiferous tubule development), signaling (cellular response to TGF-beta stimulus), and stress-related pathways (ER stress\u2013induced apoptosis, spindle checkpoint regulation, actin cytoskeleton modulation, ribosome biogenesis). The shared theme is developmental processes intertwined with cellular stress signaling and growth control, rather than a single narrow function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0071560","count":4},{"id":"GO:0016575","count":3},{"id":"GO:0042254","count":3}]},{"hash":"2131140741229934740","title":"ER Stress and Viral Replication Modulation","description":"The terms center on endoplasmic reticulum processes (ER unfolded protein response, ER-to-Golgi trafficking via COPII, ER localization) and host\u2013virus interactions that regulate viral genome replication, plus ER calcium homeostasis. Together these suggest a cohesive theme of ER stress/UPR\u2013mediated control of viral processes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044829","count":1},{"id":"GO:0030968","count":1},{"id":"GO:0090114","count":1},{"id":"GO:0006874","count":1},{"id":"GO:0044791","count":1}]},{"hash":"341093353983029423","title":"RNA processing and cell cycle regulation","description":"The cluster centers on RNA processing and splicing regulation (spliceosome-associated and mRNA splicing) plus regulation of mitotic processes (sister chromatid cohesion, spindle checkpoint, meiotic division) and ubiquitin-dependent protein catabolism, indicating a theme of post-transcriptional control linked to cell-cycle regulation. A couple of terms (pancreatic juice secretion, dendrite development) appear as outliers, likely due to multi-function annotations. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030157","count":1},{"id":"GO:0050773","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0040020","count":1},{"id":"GO:2000060","count":1}]},{"hash":"267488087464177193","title":"Lymphocyte Activation and Migration","description":"This cluster's top GO terms center on lymphocyte biology\u2014IL-7 response, B cell differentiation, and T cell proliferation\u2014alongside caveolin-mediated endocytosis and actin-driven migration, suggesting a theme of immune cell signaling and cytoskeletal remodeling.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072584","count":3},{"id":"GO:0098761","count":3},{"id":"GO:0002333","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0050798","count":3}]},{"hash":"1822018021025841527","title":"Adhesion and Cytoskeleton Signaling","description":"The proteins cluster around cell adhesion and cytoskeletal organization: receptor clustering, positive regulation of cell-matrix adhesion and cell spreading, and Rho-mediated signaling, with localization to microtubules and synapses. PDGF response and anoikis-related terms point to survival and growth-factor\u2013driven cytoskeletal remodeling, supporting a cohesive theme of adhesion-coupled signaling and cytoskeletal dynamics.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0043113","count":3},{"id":"GO:2000811","count":2},{"id":"GO:0001954","count":2},{"id":"GO:0034446","count":2}]},{"hash":"1090379721219865779","title":"Diverse Catabolic Metabolism","description":"The GO terms cluster around catabolic processes (amino acid, D-galactonate, glucarate, and cell wall macromolecule catabolic processes), suggesting a shared theme of substrate breakdown. Other terms (phylloquinone/menaquinone biosynthesis and skeletal muscle regeneration) are more peripheral, indicating some heterogeneity. Overall, the dominant signal is catabolic metabolism across various substrates, with some noise.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032889","count":3},{"id":"GO:0042372","count":2},{"id":"GO:0019596","count":2},{"id":"GO:0043403","count":2},{"id":"GO:0009234","count":2}]},{"hash":"1736150684176533221","title":"Neuronal development and stress-response signaling","description":"The terms center on brain development (cerebral cortex and corpus callosum), axon regeneration, and Akt signaling, plus cytoskeletal and apoptosis pathways (ER stress, JNK) and DNA damage signaling. This pattern points to a cluster of proteins involved in neural development coupled with stress- and survival-related signaling, rather than a single isolated process.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0032148","count":4},{"id":"GO:2000251","count":4},{"id":"GO:2000811","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0046329","count":3}]},{"hash":"932042407296714882","title":"Innate Immunity, Apoptosis, and Barrier Regulation","description":"The top GO terms center on innate immune response and apoptotic process, with additional signals of post-translational modification (sumoylation, K48-linked ubiquitination) that regulate pathways like NF-kB and IL-17, plus notes on barrier-related tight junction assembly and host suppression of viral release. This suggests a cohesive theme around host defense, cell survival regulation, and epithelial barrier function, though the small cluster and some obsolete terms indicate annotation noise.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0016925","count":1},{"id":"GO:1902187","count":1}]},{"hash":"2290895899708552196","title":"Unknown","description":"The top GO terms span diverse processes\u2014from plant development and hormone signaling to immune differentiation and telomere maintenance\u2014showing no coherent, single function that ties the proteins together. As a result, a specific, representative label cannot be determined.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:1901347","count":4},{"id":"GO:0009301","count":4},{"id":"GO:0045624","count":4},{"id":"GO:1900056","count":4},{"id":"GO:0009736","count":4}]},{"hash":"2203083819633714144","title":"Apoptosis-Immune Signaling with Wound Repair","description":"The top GO terms cluster around extrinsic apoptotic signaling (and its positive regulation), along with PI3K-AKT and ERK signaling, myeloid dendritic cell differentiation, and wound healing, plus responses to mechanical stimuli. This points to a cohesive theme of stress- or damage-induced signaling that links apoptosis and immune cell differentiation with tissue repair. Anomalous terms like odontogenesis appear incidental. ","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042489","count":3},{"id":"GO:0097192","count":3},{"id":"GO:0043011","count":3},{"id":"GO:0051092","count":3},{"id":"GO:1902895","count":3}]},{"hash":"1296673767202364868","title":"Lipid Transport and Cholesterol Homeostasis","description":"The GO terms show lipoprotein biosynthesis and transport, cholesterol import regulation, cholesterol homeostasis, and triglyceride mobilization/transport, indicating a cohesive cluster focused on lipid handling and cholesterol/triglyceride metabolism. Some terms about cholesterol biosynthetic regulation and triglyceride transport reinforce this theme, with a couple vascular-related terms likely reflecting broader physiological connections. Overall, this cluster represents lipid transport and cholesterol/triglyceride metabolic processes.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042158","count":1},{"id":"GO:0042953","count":1},{"id":"GO:0033344","count":1},{"id":"GO:1904109","count":1},{"id":"GO:0006642","count":1}]},{"hash":"269043764924535069","title":"Pigment cell transport and skin proliferation","description":"The top GO terms point to pigment cell biology, notably endosome to melanosome transport in melanocytes, alongside skin-related processes such as wound healing and hair follicle cell proliferation, with GPCR signaling as a common mechanism. Although other terms are broader (e.g., neuroblast proliferation, thymic beta selection, autophagy regulation, lipid assembly), the strongest shared theme appears to be pigment-related intracellular trafficking and skin-associated growth. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902692","count":4},{"id":"GO:0044319","count":4},{"id":"GO:0034379","count":4},{"id":"GO:0033028","count":4},{"id":"GO:0035646","count":4}]},{"hash":"768204541484453765","title":"Unknown","description":"These terms cover development (epithelial maturation in prostate gland), adipocyte differentiation, heat response, mechanosensation-related pain perception, regulation of pinocytosis, obsolete insulin-responsive glucose import, electrical coupling in cell communication, triglyceride storage regulation, and myeloid apoptotic processes. The functions are too diverse to imply a single coherent theme or pathway, and there are no observed interactions among the proteins, so the cluster cannot be confidently labeled beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060743","count":2},{"id":"GO:0045444","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0050966","count":1},{"id":"GO:0048549","count":1}]},{"hash":"123253943334561821","title":"Immune signaling and cytokine regulation","description":"The cluster's top GO terms cluster around NF-kappaB signaling, regulation of IL-1 beta production, and MHC class I biosynthesis, with supporting terms in protein ubiquitination and miRNA-mediated gene silencing. While there are a few morphogenesis terms related to heart development, the dominant theme is immune response modulation and related gene regulation, making this label the most representative despite the noise. ","confidence":"Low","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090073","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0021957","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0050713","count":1}]},{"hash":"1337615086897891826","title":"Dopaminergic regulation of movement and sensory processing","description":"The top GO terms center on locomotory behavior, regulation of sensory perception of pain, response to amphetamine, prepulse inhibition, and negative regulation of dopamine signaling and glutamatergic transmission, which together point to neural signaling pathways that modulate movement and sensory processing via dopaminergic systems. Some terms like saliva secretion and metanephric glomerulus development appear as noise, but the core cluster reflects dopaminergic/neural control of behavior.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0051482","count":3},{"id":"GO:0001975","count":3},{"id":"GO:0051967","count":3}]},{"hash":"1587229348399118549","title":"Unknown","description":"The GO terms for this cluster point to disparate biological themes (infection-structure formation, Notch signaling, B cell differentiation, intestinal development, and glycan biosynthesis), with several obsolete terms and no clear single function tying the proteins together. The lack of a cohesive biological theme and no interaction edges suggest this cluster cannot be confidently labeled beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":1},{"id":"GO:0045747","count":1},{"id":"GO:0007386","count":1},{"id":"GO:0002315","count":1},{"id":"GO:1902367","count":1}]},{"hash":"1600294726750742731","title":"TORC1-regulated Growth and Autophagy","description":"The terms center on TORC1 signaling, autophagy, and growth-related processes, including epithelial proliferation and prostate gland development, with metabolic signaling (glucose response) and RNA Pol III transcription contributing to biosynthetic activity and survival. This points to a TORC1-driven growth/autophagy module under nutrient conditions.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0038202","count":2},{"id":"GO:0045945","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0060769","count":2},{"id":"GO:2000811","count":1}]},{"hash":"138913517043820387","title":"DNA Damage Response and Stress Signaling","description":"The top GO terms cluster around DNA repair, response to ionizing radiation, apoptotic processes, and stress-related signaling (TORC1 regulation, amino acid starvation), with microtubule localization suggesting coordination with cytoskeletal dynamics. These together point to a shared theme of DNA damage response and cellular stress signaling, despite some broader terms.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1903343","count":3},{"id":"GO:1904262","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0045087","count":3}]},{"hash":"2071940910179289325","title":"Drosophila dopamine signaling and eye pigment organization","description":"This cluster\u2019s top GO terms point to neural signaling (dopamine metabolic regulation and synaptic vesicle endocytosis) alongside eye pigment granule organization, which is a hallmark of Drosophila eye development and pigmentation pathways. The ER organization and protein localization hints at general trafficking supporting these processes, making a cohesive theme around neuronal signaling and pigment/eye biology in this species.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072321","count":1},{"id":"GO:0044319","count":1},{"id":"GO:0042053","count":1},{"id":"GO:0008057","count":1},{"id":"GO:0007029","count":1}]},{"hash":"113194077122268771","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032225","count":1},{"id":"GO:0046929","count":1},{"id":"GO:0030420","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0031126","count":1}]},{"hash":"1731102389246559376","title":"Unknown","description":"The terms span sarcomere organization, T cell differentiation, nervous system development, circadian rhythms, ubiquitination and proteolysis, dendritic cell differentiation, and even plant development, indicating a highly heterogeneous set with no clear, single function tying the proteins together. Without a cohesive theme, a robust, representative label cannot be assigned.","confidence":"","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":3},{"id":"GO:0043380","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0019046","count":3},{"id":"GO:0031397","count":3}]},{"hash":"286323623266741991","title":"Neural development and stress signaling","description":"The cluster is enriched for brain development terms (cerebral cortex development, corpus callosum development) and neuronal regrowth (regulation of axon regeneration), suggesting a neural development focus. At the same time several terms relate to cellular stress and apoptosis (negative regulation of anoikis, intrinsic apoptotic signaling in response to ER stress, negative regulation of the JNK cascade), indicating accompanying stress-response regulation. Some other terms (DNA damage checkpoint signaling, meiotic DSB formation) are broader growth-related signals but do not dominate the theme. Overall, a coherent interpretation is neural development with associated stress-regulation processes.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000811","count":1},{"id":"GO:0070059","count":1},{"id":"GO:0046329","count":1},{"id":"GO:0072428","count":1},{"id":"GO:0021987","count":1}]},{"hash":"2124948525721023872","title":"Adaptive immune cell differentiation","description":"Most of the top GO terms point to immune system development, including regulation of memory T cell differentiation, positive regulation of dendritic cell differentiation, and germinal center formation, suggesting the cluster centers on adaptive immune differentiation. Supporting processes involve ubiquitin-mediated protein turnover, which can regulate signaling in immune cells. Some terms are broader developmental processes (left/right pattern formation, mesoderm development, circadian sleep/wake cycle) and less specific to immunity, but the weight of adaptive immune terms supports this label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0043380","count":2},{"id":"GO:0031397","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0042787","count":2}]},{"hash":"14236520942337146","title":"Unknown","description":"The GO terms are very heterogeneous, including neural development and calcium signaling together with cobalt/cobalamin transport, vasodilation, Wnt signaling regulation, fibrinolysis, and even a symbiont-host interaction term, which do not converge on a single clear function. Because there isn\u2019t a coherent, shared theme binding these terms, a concise representative label cannot be confidently assigned.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010976","count":2},{"id":"GO:0006824","count":1},{"id":"GO:0009235","count":1},{"id":"GO:0015889","count":1},{"id":"GO:0042311","count":1}]},{"hash":"906862058729371209","title":"Unknown","description":"The top GO terms are a mix of mitochondrial translation related processes and various catabolic/metabolic terms, plus an ER organization term and several obsolete terms, with only a single edge connecting proteins. There is no clear, cohesive shared function or pathway linking the cluster, so no intuitive label beyond Unknown can be confidently assigned.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":2},{"id":"GO:0019876","count":1},{"id":"GO:0009062","count":1},{"id":"GO:0070681","count":1},{"id":"GO:0032543","count":1}]},{"hash":"616666597064672695","title":"Endothelial angiogenesis and BMP signaling regulation","description":"The top GO terms point to vascular biology: endothelial activation/differentiation, endothelial proliferation in angiogenesis, and processes like blood coagulation. Negative regulation of BMP signaling also ties to developmental control of vascular contexts. A few terms (ureteric bud development, sensory perception, locomotory behavior) may reflect broader developmental roles but are less central. Therefore, this label captures the core function of the cluster: endothelial angiogenesis with BMP pathway regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0042118","count":1},{"id":"GO:0001657","count":1},{"id":"GO:0007605","count":1}]},{"hash":"668429842268726816","title":"Glial growth and migration regulation","description":"This cluster prominently features GO terms for negative regulation of glial cell proliferation and negative regulation of glial cell migration, suggesting a shared theme around controlling glial cell behavior. While several metabolic terms appear as well, the glial regulation annotations provide the strongest, specific signal for naming. Confidence: Medium","confidence":"","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060253","count":1},{"id":"GO:0006099","count":1},{"id":"GO:1903976","count":1},{"id":"GO:0006537","count":1},{"id":"GO:0019878","count":1}]},{"hash":"2015745270491954764","title":"Neural development and inflammatory signaling","description":"The top terms cluster around neural development (corpus callosum development, corticospinal neuron axon guidance, positive regulation of synapse assembly) and inflammatory signaling (inflammatory response, positive regulation of interleukin-18 production). Wnt signalosome assembly also ties into developmental signaling. There is one plant-specific term (regulation of meristem structural organization) that seems unrelated, but the dominant pattern points to neural connectivity and immune/pain-related signaling, making this label a reasonable, though not perfect, summary. ","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0009934","count":3},{"id":"GO:1904887","count":3},{"id":"GO:0032741","count":3},{"id":"GO:0072224","count":3},{"id":"GO:0021972","count":3}]},{"hash":"375187785757998173","title":"Coagulation and ECM remodeling","description":"This cluster centers on processes related to blood coagulation, fibrinolysis, and tissue remodeling (elastin catabolic process, embryo implantation, digestive system development), with supportive signals of immune regulation and transcriptional control. The common theme appears to be coagulation-associated tissue remodeling during development and repair, rather than a single, narrow pathway.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0007566","count":4},{"id":"GO:0045944","count":3},{"id":"GO:0032733","count":3},{"id":"GO:0055123","count":3}]},{"hash":"1021799009939568585","title":"Dopaminergic Neuronal Signaling and Behavior","description":"The cluster shows dominant terms related to neural communication and behavior: dopaminergic synaptic transmission, neuropeptide signaling, pain perception, and grooming behavior, plus astrocyte chemotaxis regulation. While a couple terms touch on non-neural development, the core signal is dopamine-driven neuronal signaling and its behavioral outputs, suggesting a cohesive neural signaling module.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":4},{"id":"GO:0072224","count":4},{"id":"GO:0060160","count":4},{"id":"GO:0048484","count":4},{"id":"GO:2000458","count":4}]},{"hash":"1421338492970212399","title":"Synaptic Vesicle Trafficking and Signaling","description":"The cluster shows multiple GO terms tied to vesicle loading/fusion and synaptic transmission, including regulation of vesicle fusion, vesicle cargo loading, chemical synaptic transmission, receptor localization to synapse, and regulation of synaptic plasticity. Although other terms touch growth or SMAD signaling, the strongest signal is vesicle trafficking at the synapse, suggesting the proteins are involved in neurotransmitter release and synaptic organization.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046726","count":1},{"id":"GO:0035264","count":1},{"id":"GO:0031338","count":1},{"id":"GO:0007268","count":1},{"id":"GO:0035459","count":1}]},{"hash":"1510220544153688947","title":"Fatty acid metabolism and transport","description":"The top GO terms are dominated by lipid metabolic processes related to fatty acid beta-oxidation, carnitine-linked metabolism, and transport of long-chain fatty acids, including positive regulation of beta-oxidation. While a couple of RNA processing and acetylcholine biosynthesis terms appear, the strongest signal is fatty acid metabolism and transport, suggesting this cluster centers on lipid catabolism and lipid handling rather than RNA processing or neurotransmitter synthesis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019254","count":1},{"id":"GO:0033540","count":1},{"id":"GO:0032000","count":1},{"id":"GO:0015909","count":1},{"id":"GO:0001547","count":1}]},{"hash":"88018721368526399","title":"Neural development and muscle/heart formation","description":"Top GO terms indicate strong signals for nervous system development, neurogenesis, and synapse assembly, alongside heart development and striated muscle assembly. This pattern suggests the cluster comprises proteins involved in broad developmental programs spanning neural tissue formation and cardiomuscular differentiation, rather than a single, shared molecular function. Hence the label reflects a cohesive developmental theme across neural and muscular/cardiac lineages.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":2},{"id":"GO:0019226","count":2},{"id":"GO:0007432","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007417","count":2}]},{"hash":"1516846235809714339","title":"Neural development and vision-related processes","description":"The top GO terms center on vision and retinal neuron differentiation (phototransduction, retinal bipolar neuron differentiation) with additional neural development signals (substantia nigra development, long-term memory). Some terms are obsolete or peripheral (e.g., cuticle development, phosphatase regulation), so the label focuses on the core neural/vision theme, though imperfectly cohesive across all terms.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007602","count":1},{"id":"GO:0060040","count":1},{"id":"GO:0043065","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0008365","count":1}]},{"hash":"633821012957237558","title":"Glycolysis and TCA Core Metabolism","description":"This cluster is enriched for glycolysis (GO:0006096) and the tricarboxylic acid cycle (GO:0006099) with supporting links to pyruvate and glutamine metabolism and thiamine biosynthesis, pointing to central carbon metabolism and energy production. Some terms like nutrient response and cell-wall biosynthesis are less central but do not dominate, so the core theme is metabolism.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0007584","count":2},{"id":"GO:0006541","count":2},{"id":"GO:0055114","count":2}]},{"hash":"2070454172749388113","title":"Actin Cytoskeleton Remodeling and EMT","description":"This cluster is enriched for GO terms on microvillus and podosome assembly and actin cytoskeleton organization, plus regulation of epithelial-to-mesenchymal transition and cell-cell adhesion. These signals converge on dynamic actin remodeling linked to cell migration and adhesion changes; the other terms appear less connected.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030033","count":3},{"id":"GO:0071800","count":3},{"id":"GO:0031532","count":2},{"id":"GO:0022408","count":2},{"id":"GO:0030826","count":2}]},{"hash":"1619951347845735617","title":"Neuronal Development and MAPK Signaling","description":"The GO terms cluster around nervous system development (including hippocampus development), neuronal responses (dopamine signaling), and multiple kinase signaling cascades (JNK/ERK) and pathways (Wnt), suggesting proteins involved in neural development and related signal transduction. Some terms are more general (e.g., beta selection, mRNA processing) but do not outweigh the overarching neural-development/signal-transduction theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0043366","count":3},{"id":"GO:0046330","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0090263","count":3}]},{"hash":"1208074987743516543","title":"Innate and adaptive immune activation","description":"Based on the enrichment for innate immune response, complement activation, phagocytosis, B cell signaling and activation, and STAT tyrosine phosphorylation, the cluster centers on immune system activation involving both innate and adaptive components. The combination of B cell\u2013specific signaling and phagocytic/innate processes supports a unified theme of immune activation.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0042511","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0006910","count":3},{"id":"GO:0006958","count":3}]},{"hash":"351569813427608704","title":"Diversified metabolite biosynthesis","description":"Based on GO terms such as poly-hydroxybutyrate biosynthetic process, sphingolipid biosynthesis, fatty acid elongation, melanin biosynthesis, phylloquinone catabolic process, tetrahydrobiopterin biosynthetic process, glucocorticoid biosynthesis, and other biosynthetic processes, the proteins appear to be involved in producing a range of metabolites (lipids, pigments, vitamins/cofactors, and hormones). Although one term is catabolic and another obsolete, the dominant theme is biosynthesis of diverse compounds, suggesting a cluster of enzymes with broad biosynthetic roles rather than a single dedicated pathway.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0042376","count":3},{"id":"GO:0030435","count":3},{"id":"GO:0042438","count":3}]},{"hash":"1727666431404255561","title":"Unknown","description":"The GO terms are highly diverse, covering secretion (pancreatic juice, saliva), sensory perception, various environmental responses, cytoskeletal polarity, and multiple transport processes, with no clear shared function or pathway linking the four proteins. The lack of edges and the single-term counts further argue against a cohesive, well-defined cluster. Unknown seems most appropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030157","count":1},{"id":"GO:0046541","count":1},{"id":"GO:0080029","count":1},{"id":"GO:0042631","count":1},{"id":"GO:0072239","count":1}]},{"hash":"187484017309713841","title":"Dopaminergic Neuron Signaling and Development","description":"The cluster is best described by nervous system\u2013related functions, with multiple terms pointing to neural signaling and development: neuropeptide signaling, dopaminergic synaptic transmission, sensory perception of pain, grooming behavior, and regulation of astrocyte chemotaxis. Some terms like saliva secretion or kidney development appear as noise, but the core theme is dopaminergic neurotransmission and neural development.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046541","count":2},{"id":"GO:0072224","count":2},{"id":"GO:0060160","count":2},{"id":"GO:0048484","count":2},{"id":"GO:2000458","count":2}]},{"hash":"1869946490053594616","title":"Embryonic brain and organ development","description":"The GO terms point to developmental and morphogenetic processes such as brain development, embryonic digit morphogenesis, and ureteric bud morphogenesis, suggesting a theme of embryonic organ formation and neural development. A few generic terms (regulation of binding, behavior) are present but do not change the overall pattern.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051098","count":1},{"id":"GO:0044708","count":1},{"id":"GO:0021985","count":1},{"id":"GO:1905045","count":1},{"id":"GO:0090190","count":1}]},{"hash":"1296991051658740607","title":"Immune cell activation and adhesion","description":"This cluster centers on immune signaling and developmental processes (NFAT pathway regulation, beta selection in T cells, isotype switching in B cells) and includes adhesion-related terms (cell-cell and cell-matrix adhesion) plus cellular defense responses, suggesting a cohesive theme of immune activation and immune-cell interactions, including microglial involvement.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001953","count":3},{"id":"GO:1904151","count":3},{"id":"GO:0051463","count":3},{"id":"GO:0016337","count":3},{"id":"GO:0006968","count":3}]},{"hash":"1502021395306090678","title":"Drosophila oocyte polarity and mRNA localization","description":"The top terms strongly point to oocyte development and axis formation (bicoid and oskar mRNA localization, oocyte nucleus migration, axis specification), indicating a theme around Drosophila oocyte polarity and mRNA localization. Some other terms (synaptic and receptor regulation, Notch signaling, ER-Golgi transport) seem less central to this theme, possibly reflecting broader roles of the proteins, but the dominant pattern is oocyte polarity and mRNA localization.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902684","count":1},{"id":"GO:0007120","count":1},{"id":"GO:0045450","count":1},{"id":"GO:0045451","count":1},{"id":"GO:0006888","count":1}]},{"hash":"239111322379334163","title":"Organelle-specific autophagy","description":"The top GO terms cluster around autophagy-related processes\u2014autophagosome maturation, autophagy of mitochondrion, glycophagy, reticulophagy, and the Cvt pathway\u2014indicating the proteins are involved in selective, organelle-targeted autophagy. A few auxiliary terms (stress responses) appear but do not override the autophagy signal.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":3},{"id":"GO:0000422","count":3},{"id":"GO:0061723","count":3},{"id":"GO:0040024","count":3},{"id":"GO:0044805","count":3}]},{"hash":"1914620073277553654","title":"T cell activation and cytokine regulation","description":"The top GO terms point to adaptive immune functions, including T cell apoptotic process, T cell costimulation, positive regulation of cytokine production (including IL-10), and humoral immune response, along with fever modulation by prostaglandins. While there are some metabolic and developmental terms, the dominant theme is T cell\u2013mediated signaling and inflammatory regulation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0070231","count":3},{"id":"GO:0046325","count":3},{"id":"GO:0050715","count":3},{"id":"GO:0031295","count":3},{"id":"GO:0032733","count":3}]},{"hash":"1227477651414888743","title":"Bacterial cell wall biosynthesis and turnover","description":"Top terms center on peptidoglycan biosynthesis and turnover and cell wall organization, suggesting a focus on bacterial cell envelope dynamics. The inclusion of cell cycle/division terms supports a general bacterial cellular context, while a few outliers may reflect annotation noise or cross-t taxa annotations. Overall, the cluster is best described as bacteria-specific cell wall biogenesis and remodeling.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008360","count":1},{"id":"GO:0009252","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0009254","count":1},{"id":"GO:0051301","count":1}]},{"hash":"460288597963915064","title":"Embryonic Development and Organ Morphogenesis","description":"The top GO terms cluster around broad developmental processes and organogenesis across multiple tissues (brain, hindlimb, kidney branching, lung mesenchyme, thyroid differentiation, cardiac and fibroblast proliferation, and general multicellular development), indicating a cohesive theme of developmental regulation and tissue morphogenesis rather than a single specific function.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0033278","count":2},{"id":"GO:0021536","count":2},{"id":"GO:0060129","count":2},{"id":"GO:0001658","count":2}]},{"hash":"1727045452929837762","title":"Capsule and cell wall polysaccharide biosynthesis","description":"This cluster is dominated by GO terms related to bacterial polysaccharide production for the cell envelope, including cell wall and capsule biosynthesis, mycolate layer assembly, and UDP-sugar metabolism, plus cell wall organization. These together indicate a cohesive module for assembling capsule and other cell wall polysaccharides, rather than signaling or immune processes, justifying a focused label on envelope polysaccharide biosynthesis.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070592","count":3},{"id":"GO:0045227","count":3},{"id":"GO:0071769","count":3},{"id":"GO:0052573","count":3},{"id":"GO:0071555","count":3}]},{"hash":"485872401255470188","title":"Neuroimmune Adhesion and NFAT Signaling","description":"The term set centers on cell adhesion (cell-matrix and cell-cell), immune-related processes (microglial cytotoxicity, B cell differentiation, cellular defense), and signaling through the calcineurin-NFAT axis, plus nuclear localization, all of which together point to an interplay between neural and immune functions involving adhesion and NFAT-regulated signaling. This yields a coherent, specific label without overgeneralizing to unrelated functions.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001953","count":3},{"id":"GO:0048679","count":3},{"id":"GO:1904151","count":3},{"id":"GO:1903387","count":3},{"id":"GO:0051463","count":3}]},{"hash":"1070454127912111020","title":"Innate antiviral stress response","description":"The top GO terms indicate innate immune signaling and regulation of translation initiation via eIF2\u03b1 phosphorylation, both features of antiviral defense and cellular stress responses. Although a few terms are less coherent (e.g., mRNA processing or adherens junctions), the dominant pattern centers on immune/stress control of protein synthesis and viral replication, supporting this label.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":2},{"id":"GO:0010998","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0045071","count":2}]},{"hash":"829473293306880712","title":"Adaptive immunity signaling and lymphocyte development","description":"The terms cluster around immune activation and lymphocyte maturation, including regulation of NFAT/calcium signaling (key to T cell activation), beta selection (T cell development), IgE isotype switching (B cell function), and cellular defense. Additional cell adhesion relates to immune cell interactions. While a developmental term like hard palate development exists, the dominant theme is adaptive immune signaling and lymphocyte development.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001953","count":3},{"id":"GO:1904151","count":3},{"id":"GO:0051463","count":3},{"id":"GO:0016337","count":3},{"id":"GO:0060022","count":3}]},{"hash":"2263055834214333868","title":"Cellular stress response signaling","description":"The GO terms cluster around intracellular signal transduction and stress-related responses, including DNA damage tolerance, ER-stress\u2013triggered apoptotic signaling, and spindle assembly checkpoint regulation, which together suggest a module involved in coordinating cellular stress responses. Some terms (ribosome biogenesis, actin nucleation regulation, growth responses) appear more peripheral, indicating a small, stress-oriented cluster with some noise. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":2},{"id":"GO:2001022","count":1},{"id":"GO:0006301","count":1},{"id":"GO:0016575","count":1},{"id":"GO:0042254","count":1}]},{"hash":"146225085142593409","title":"Unknown","description":"The terms span diverse developmental contexts (follicle cell formation, gastrulation, neural patterning, ventral cord development) and immune system development (V(D)J recombination, T cell proliferation), plus regulatory processes like autoubiquitination and X chromosome inactivation. There isn\u2019t a single coherent function or pathway tying these proteins together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030713","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0001702","count":3},{"id":"GO:0090073","count":3},{"id":"GO:0021903","count":3}]},{"hash":"2064873344201833304","title":"Neuronal Axonogenesis and Transport","description":"The top terms emphasize peripheral nervous system neuron axonogenesis, retrograde axonal transport, and maintenance of microtubule cytoskeleton polarity, which together point to neuronal cytoskeleton dynamics and axon growth/transport as the cluster\u2019s common function. Some terms are obsolete or relate to unrelated processes, but the core signal is neuronal development and intracellular transport.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031443","count":3},{"id":"GO:0043000","count":3},{"id":"GO:0090343","count":3},{"id":"GO:0035105","count":3},{"id":"GO:1904714","count":3}]},{"hash":"388241074988827164","title":"Ribosome biogenesis and cell cycle progression","description":"These proteins cluster around core growth and proliferation processes: ribosome biogenesis and translation initiation point to high protein synthesis, while cell division and spindle checkpoint regulation indicate cell cycle progression. Actin nucleation regulation and ER-stress\u2013related apoptosis add layers of cytoskeletal control and stress response that commonly accompany growth. Some development terms may be incidental, but the dominant theme is protein production and cell division machinery.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0016575","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0001403","count":3},{"id":"GO:0072520","count":3},{"id":"GO:0070059","count":3}]},{"hash":"1177008507397707856","title":"Chromatin modification and transcription regulation","description":"The cluster\u2019s terms center on histone acetylation and chromatin maintenance (histone H3/H4 acetylation, centromere/heterochromatin maintenance) and on transcriptional regulation, with some development-oriented terms (sensory organ precursor fate, imaginal disc fusion) suggesting that chromatin state governs developmental gene expression.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0016239","count":2},{"id":"GO:0034508","count":2},{"id":"GO:1902368","count":2},{"id":"GO:0001207","count":2}]},{"hash":"732710418633305661","title":"Neural development and signaling","description":"The top GO terms emphasize nervous system development and function (Schwann cell development, visual perception, long-term potentiation) with broader development processes also present, suggesting proteins involved in neural development and signaling pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0010800","count":2},{"id":"GO:0014044","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0007601","count":2}]},{"hash":"383628335350434338","title":"Neural development and signaling","description":"The top GO terms cluster around nervous system development and signaling cascades, including ROBO signaling, positive regulation of Wnt and ERK cascades, and cellular response to dopamine, suggesting a role in neuronal development and signal transduction rather than immune or bone processes.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043366","count":3},{"id":"GO:0046330","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0002551","count":3}]},{"hash":"1094110905565542303","title":"Chromatin organization and transcription regulation","description":"This cluster\u2019s top GO terms cluster around chromatin state and nuclear architecture (heterochromatin formation, nucleosome density, cohesin-related processes, rDNA localization, and transcriptional regulation), suggesting a theme of chromatin organization impacting transcription. While a few terms touch on developmental processes, the central pattern is chromatin remodeling and transcription control.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010621","count":3},{"id":"GO:0006346","count":3},{"id":"GO:0060303","count":3},{"id":"GO:0032874","count":3},{"id":"GO:0090050","count":3}]},{"hash":"330992839299693486","title":"CD40\u2013NF-\u03baB Immune Signaling and Golgi Trafficking","description":"This set is dominated by CD40 signaling and NF-kappaB\u2013related inflammatory regulation, with additional links to Golgi-associated trafficking and receptor recycling, plus autophagy and ERK regulation. The common theme is CD40-driven immune signaling coordinated with intracellular trafficking.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001920","count":2},{"id":"GO:0023035","count":2},{"id":"GO:0000042","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0016236","count":2}]},{"hash":"240119535962371982","title":"Chromatin Regulation and Genome Maintenance","description":"The cluster centers on chromatin state control and genome integrity, with multiple GO terms related to nucleosome density, histone modification/desuccinylation, and RNA polymerase II transcription regulation in stress conditions, plus replication-born double-strand break repair via sister chromatid exchange. While a couple of terms touch metabolism and stem cell proliferation, the strongest signal is chromatin modification and DNA repair, suggesting proteins in this cluster participate in maintaining chromatin structure and genome stability.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046325","count":2},{"id":"GO:0060303","count":2},{"id":"GO:2000773","count":2},{"id":"GO:0042593","count":2},{"id":"GO:0036049","count":2}]},{"hash":"1071943958831970306","title":"Cytokinin Signaling and Leaf Senescence Regulation","description":"The cluster centers on cytokinin-activated signaling and negative regulation of leaf senescence, indicating a plant-specific theme where cytokinins delay senescence; other terms appear peripheral and do not redefine the main theme.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:1901347","count":1},{"id":"GO:0009301","count":1},{"id":"GO:0070198","count":1},{"id":"GO:1904430","count":1}]},{"hash":"2250008774084928222","title":"Unknown","description":"Top terms span immune maturation, heart development, VEGF and prostaglandin signaling, hyaluronan metabolism, JNK regulation, and phosphorylation, with no single cohesive function tying all proteins together. Therefore, a concise, representative label cannot be assigned beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046329","count":2},{"id":"GO:0018107","count":2},{"id":"GO:0098761","count":2},{"id":"GO:0016477","count":2},{"id":"GO:2001275","count":2}]},{"hash":"1400972494234596307","title":"Glutamatergic synaptic signaling and photoreception","description":"The cluster\u2019s top GO terms point strongly to neuronal signaling and sensory processes: glutamatergic regulation of synaptic transmission, GPCR signaling pathways related to glutamate receptors, and detection of light for visual perception, plus related memory and locomotion aspects. While a couple terms (e.g., electron transport chain, cell wall macromolecule catabolic process) are less aligned, the dominant theme is glutamatergic synaptic communication and photoreception.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":3},{"id":"GO:0050908","count":3},{"id":"GO:0071257","count":3},{"id":"GO:0038042","count":3},{"id":"GO:0051966","count":3}]},{"hash":"1590540093053276930","title":"Wnt/PCP signaling and cytoskeletal regulation","description":"Top terms indicate planar cell polarity establishment, Wnt signaling, Rho GTPase regulation, and actin dynamics, with developmental processes like wing formation and convergent extension, pointing to a cluster of proteins involved in PCP signaling and cytoskeletal remodeling.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030845","count":2},{"id":"GO:0070560","count":2},{"id":"GO:0090163","count":2},{"id":"GO:0060069","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1015921342135201440","title":"Ubiquitin-mediated proteostasis and aggresome formation","description":"The enriched terms point to ubiquitin-related processes: deubiquitination (linear and K6-linked), ubiquitin recycling, and components of ERAD, together with aggresome assembly. These indicate a theme of ubiquitin-dependent protein quality control and aggregate handling, with more peripheral hints like protein localization to the cell surface and CNS morphogenesis possibly reflecting broader roles of the proteins. Overall, a proteostasis/aggresome-focused interpretation fits best.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034394","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0007026","count":2},{"id":"GO:1990108","count":1},{"id":"GO:0044313","count":1}]},{"hash":"986371883410747336","title":"Apoptosis and Autophagy Regulation","description":"This cluster\u2019s strongest shared signals are ribophagy and positive regulation of apoptotic process, pointing to roles in autophagy-related control of cell survival and death. The other terms (dopamine secretion, brain development, B cell signaling/differentiation, and angiogenesis) suggest pleiotropic roles for these proteins in diverse contexts, but do not form a single cohesive function beyond stress-response and cellular remodeling. Confidence: Medium","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071236","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0034517","count":2},{"id":"GO:0014059","count":2}]},{"hash":"1295463456603722386","title":"Glutamatergic Synaptic Transmission","description":"The top GO terms are dominated by glutamatergic synaptic signaling, with emphasis on synaptic transmission and excitatory postsynaptic potentials, indicating the proteins are likely involved in excitatory neurotransmission at glutamatergic synapses. Additional terms like sodium ion transport and electron transport chain reflect neuronal excitability and energy requirements, while other terms touch development or adhesion, but the core signal centers on glutamatergic synapse function.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0001701","count":2},{"id":"GO:0007160","count":2}]},{"hash":"1926952060523848135","title":"Unknown","description":"The top GO terms are very diverse (pregnancy-related processes, collagen biosynthesis, various stimulus responses, and metabolic/transporter activities) with no clear single function tying the three proteins together. The mix suggests no cohesive biological theme, so a precise label isn\u2019t supported.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010963","count":2},{"id":"GO:0060135","count":2},{"id":"GO:0032964","count":2},{"id":"GO:0010042","count":2},{"id":"GO:0071549","count":2}]},{"hash":"1161443991000882561","title":"Unknown","description":"The cluster contains 3 proteins but has no GO terms or connections to reveal a shared function, so no reliable functional theme can be inferred from the data provided.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"603476007537124542","title":"Neddylation and Ubiquitination Regulation","description":"This cluster\u2019s top GO terms center on the regulation and execution of protein neddylation (and related ubiquitin-protein transferase activity), along with protein catabolic processes. The presence of both positive and negative regulation of neddylation suggests a core functional theme around NEDD8-mediated modification and its control, which often interfaces with ubiquitin-proteasome\u2013driven proteolysis and cellular stress responses (including radiation-related signals) and may extend to cytoskeletal dynamics. Overall, the common thread appears to be post-translational modification by neddylation and its regulation within proteostasis and stress contexts.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000436","count":1},{"id":"GO:0010332","count":1},{"id":"GO:2000435","count":1},{"id":"GO:0044254","count":1},{"id":"GO:0051443","count":1}]},{"hash":"551118036648649753","title":"Unknown","description":"The three proteins show a highly diverse set of GO terms, including sarcomere organization, nervous system development, circadian rhythm, immune cell differentiation, and ubiquitination processes, with no clear, shared biological process. This suggests the cluster does not map to a single coherent function.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":1},{"id":"GO:0043380","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0019046","count":1},{"id":"GO:0031397","count":1}]},{"hash":"1019920083872870044","title":"Energy metabolism and redox balance","description":"This cluster centers on core metabolic pathways: TCA cycle, glyoxylate cycle, glutathione metabolism, and NADP biosynthesis, indicating energy production and redox homeostasis as the dominant theme. The presence of a couple of neural-related terms (negative regulation of glial cell proliferation/migration) appears weaker and may reflect annotation noise or broader regulatory links, but the strongest signal is metabolic. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060253","count":2},{"id":"GO:0006099","count":2},{"id":"GO:1903976","count":2},{"id":"GO:0006537","count":2},{"id":"GO:0019878","count":2}]},{"hash":"2293629634544586338","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms related to neural development and connectivity, including retinal ganglion cell axon guidance, CNS projection neuron axonogenesis, forebrain development, corpus callosum development, and positive regulation of synapse assembly. While a few terms touch on non-neural processes (heart, placenta, myotube differentiation, T cell activation), the strongest and most frequent signals point to neural patterning and axon guidance, suggesting these proteins contribute to CNS development and axon pathfinding.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":3},{"id":"GO:0022038","count":2},{"id":"GO:0021952","count":2},{"id":"GO:0050798","count":2},{"id":"GO:0014902","count":2}]},{"hash":"991625018677733285","title":"LPS-responsive lipid metabolism","description":"The proteins appear linked by an LPS-driven inflammatory context, with GO terms showing response to lipopolysaccharide, prostaglandin metabolic processes, and fatty acid omega-oxidation, suggesting involvement in lipid mediator production and detoxification during inflammation. The extracellular negative regulation of signal transduction aligns with modulatory signaling during immune responses. Some terms are obsolete, but the core theme centers on LPS-related inflammatory lipid pathways.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0032496","count":3},{"id":"GO:0006069","count":3},{"id":"GO:0019518","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0010430","count":3}]},{"hash":"2013863587764266606","title":"Neural lipid metabolism and synaptic signaling","description":"The top GO terms include nervous system development, chemical synaptic transmission, sensory perception of sound, and ganglioside (lipid) catabolic processes. Together these point to neural biology where ganglioside metabolism supports membrane composition and signaling in neurons, hence a focus on neural lipid metabolism and synaptic function. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051692","count":1},{"id":"GO:0009405","count":1},{"id":"GO:0006689","count":1},{"id":"GO:0007156","count":1},{"id":"GO:0048023","count":1}]},{"hash":"1781335257933796436","title":"Proteoglycan Biosynthesis and Sulfation","description":"The GO terms point to glycosaminoglycan production (heparan sulfate/heparin, chondroitin sulfate) and protein sulfation, suggesting enzymes involved in assembling and modifying proteoglycans. The inclusion of xenobiotic, catecholamine, and thyroid hormone metabolism aligns with sulfation-related processes, while developmental term embryonic neurocranium morphogenesis hints at proteoglycan roles in development. Overall, a cohesive theme is proteoglycan biosynthesis and related sulfation activities.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045600","count":3},{"id":"GO:0030210","count":3},{"id":"GO:0006805","count":3},{"id":"GO:0006477","count":3},{"id":"GO:0030573","count":3}]},{"hash":"1840186996243271053","title":"Bacterial cell wall catabolism and host defense","description":"The cluster\u2019s strongest signals are peptidoglycan and cell wall macromolecule catabolic processes and defense response to bacterium, pointing to a theme of bacterial cell wall remodeling and host immune defense. Some terms like cytolysis and viral release are outliers, but the core terms support this cohesive interpretation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051930","count":3},{"id":"GO:0019835","count":3},{"id":"GO:0019076","count":3},{"id":"GO:0009253","count":3},{"id":"GO:0007194","count":3}]},{"hash":"1165089169393633727","title":"Melanosome transport and organization","description":"Based on the Top Terms, the cluster is strongly enriched for melanosome-related processes: melanosome transport, melanosome organization, and regulation of melanosome organization and transport. Calcium- and phosphatidylinositol-mediated signaling terms appear as supporting context, potentially linking signaling to organelle movement. A few terms (saliva secretion, dopamine signaling regulation) seem unrelated noise, but the dominant theme is melanosome dynamics.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048015","count":1},{"id":"GO:1903056","count":1},{"id":"GO:0032402","count":1},{"id":"GO:1902908","count":1},{"id":"GO:0032438","count":1}]},{"hash":"602348237290420044","title":"Hepatic Growth and Vascular Regulation","description":"The terms emphasize liver-related processes (liver regeneration, hepatocyte proliferation) with metabolic (insulin processing) and circulatory control (angiotensin regulation, bradykinin catabolism), suggesting a hepatic growth/metabolic-vascular theme rather than a non-specific set of functions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000346","count":2},{"id":"GO:0002002","count":2},{"id":"GO:0035609","count":2},{"id":"GO:0010815","count":2},{"id":"GO:0009408","count":2}]},{"hash":"291927302493902187","title":"Neural Development","description":"The top GO terms point to neural and sensory tissue formation and maturation (myelination, Schwann cell differentiation, neuroblast development, retinal rod cell development), with supporting patterns in nervous system development and related structures. A few terms (e.g., wing disc patterning, epidermis development, transcription regulation) are broader but do not override the clear neural-development signal.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0014019","count":2},{"id":"GO:0016480","count":2},{"id":"GO:0001958","count":2},{"id":"GO:0045892","count":2}]},{"hash":"469211352195201291","title":"Unknown","description":"The GO terms are highly diverse, spanning proteoglycan biosynthesis, nucleotide biosynthesis, immune signaling, development, transport, and cell cycle regulation. This scattered set provides no clear shared function for the cluster, so a precise, representative label cannot be assigned with confidence.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050650","count":2},{"id":"GO:0006183","count":1},{"id":"GO:0046651","count":1},{"id":"GO:0060041","count":1},{"id":"GO:0055114","count":1}]},{"hash":"2241553054226520493","title":"Embryonic development and morphogenesis","description":"The GO terms point to broad developmental and morphogenetic processes, including brain development, embryonic digit morphogenesis, neurohypophysis development, and ureteric bud morphogenesis, suggesting a cluster tied to embryonic organ development rather than a single pathway. Some terms about regulation (binding, protein oligomerization/oxidation) may reflect regulatory roles during development but do not converge on a single specialized function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032461","count":1},{"id":"GO:1904808","count":1},{"id":"GO:0051098","count":1},{"id":"GO:0044708","count":1},{"id":"GO:0021985","count":1}]},{"hash":"297984815332508750","title":"Translation Machinery and Regulation","description":"The top GO terms point to core components and regulators of protein synthesis, including cytoplasmic and mitochondrial translation, initiation, elongation, and termination, as well as selenocysteine incorporation. While a couple of terms touch on RNA processing and chromatin-related RNA silencing, the dominant signal is translation and its control, suggesting this cluster represents factors involved in translating mRNA into protein and modulating translation efficiency.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000767","count":3},{"id":"GO:0001514","count":3},{"id":"GO:0006415","count":3},{"id":"GO:1902802","count":3},{"id":"GO:0045901","count":3}]},{"hash":"1656946726163756890","title":"Retinoic acid signaling in neural development and angiogenesis","description":"Top GO terms indicate a shared involvement in cellular response to retinoic acid and promotion of angiogenesis, with supporting hints from cerebral cortex development. This suggests RA signaling as a driver of neural development and vascularization, making a concise label focusing on RA-driven neural development and angiogenesis appropriate. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0071300","count":2},{"id":"GO:0045766","count":2},{"id":"GO:2000811","count":1},{"id":"GO:0070059","count":1}]},{"hash":"1693546588173263125","title":"Autophagy and Organelle Turnover","description":"The top GO terms are dominated by autophagy-related processes (autophagosome assembly, autophagy of mitochondrion, glycophagy, piecemeal microautophagy of the nucleus, ER-overload\u2013induced autophagy, etc.), indicating a coherent functional theme around autophagy pathways and selective degradation of organelles. Some terms (like phagocytosis regulation or membrane targeting) are ancillary, but the central cluster clearly centers on autophagy and related turnover processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044805","count":1},{"id":"GO:0000045","count":1},{"id":"GO:0034263","count":1},{"id":"GO:0050765","count":1},{"id":"GO:0006501","count":1}]},{"hash":"999246975734807317","title":"Neural and craniofacial development genes","description":"The top GO terms cluster around development of neural and craniofacial structures (cerebral cortex, cerebellum, face development, motor neuron axon guidance) and transcriptional regulation (DNA-templated transcription), indicating a theme of developmental regulation in neural and craniofacial contexts. A few terms (e.g., lipopolysaccharide response) may be incidental noise rather than central to the cluster.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":2},{"id":"GO:0021987","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0021549","count":2}]},{"hash":"1869812238603329501","title":"SNARE-Mediated Synaptic Vesicle Trafficking","description":"Dominant terms point to vesicle transport and fusion, especially endosome-to-endosome transport, synaptic vesicle docking, and SNARE complex assembly, plus receptor localization to the synapse. These together suggest a core function in vesicular trafficking and SNARE-driven fusion at synapses, with a few peripheral terms related to secretory pathways. Thus the label reflects the cluster's likely role.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045022","count":2},{"id":"GO:0016081","count":1},{"id":"GO:2000010","count":1},{"id":"GO:0097352","count":1},{"id":"GO:1902685","count":1}]},{"hash":"840004579610205874","title":"Unknown","description":"There are no GO terms or connections linking the proteins in this cluster, and the graph has no edges or shared terms, so there is no clear shared function to label. The safest designation is Unknown with no confidence score. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"929124361721994922","title":"T cell activation and cytokine regulation","description":"The cluster\u2019s top GO terms are dominated by immune signaling events: T cell costimulation, cytokine production (including IL-4), and regulation of T cell activation via TCR-MHC interactions, along with related neutrophil trafficking and MyD88/TLR signaling. While a few terms are unrelated (spermatid development, cardiac depolarization, adipocyte proliferation), the strongest pattern points to adaptive immune response and cytokine regulation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045404","count":2},{"id":"GO:0031295","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0060371","count":2}]},{"hash":"381739968355823233","title":"Unknown","description":"The GO terms are a scattered mix across species (plant seed mucilage, root hair development; insect visual primordium; diverse adhesion terms) and glycosylation processes, with no single shared function tying the proteins together, making a coherent label impractical.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":1},{"id":"GO:0070267","count":1},{"id":"GO:0018258","count":1},{"id":"GO:0075015","count":1},{"id":"GO:0007299","count":1}]},{"hash":"2181311424432847475","title":"RNA and protein methylation","description":"The GO terms center on methylation activities, including RNA guanine-N7 methylation, mRNA capping, rRNA methylation, and several protein methylations (peptidyl-arginine methylation and N-terminal methylation). This pattern suggests a shared function in methyltransferase-mediated modifications of both RNA and proteins within the cluster.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010243","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0042418","count":2},{"id":"GO:0031100","count":2}]},{"hash":"303596003262424250","title":"Mitochondrial metabolite transporters","description":"The top GO terms point to transport of nutrients, cofactors, and ions into or across mitochondrial membranes (pyridoxal phosphate, thiamine pyrophosphate, thiosulfate, phosphate, iron), coupled with related mitochondrial processes such as the malate-aspartate shuttle, iron import into mitochondrion, mitochondrial apoptosis, and adaptive thermogenesis. This suggests a cohesive theme of mitochondrial metabolite/ion transport and carrier activity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031921","count":2},{"id":"GO:1990314","count":2},{"id":"GO:0015709","count":2},{"id":"GO:0008637","count":2},{"id":"GO:0043490","count":2}]},{"hash":"2077929689441536280","title":"Embryonic organ morphogenesis","description":"The GO terms center on morphogenesis across several organs\u2014heart structures (endocardial cushion morphogenesis, atrial septum formation), enteric nervous system development, and endodermal cell fate\u2014suggesting a shared role in embryonic organ development. While some terms touch on immune signaling and transcription, the dominant theme is developmental organogenesis, especially cardiac and neural lineages.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007493","count":3},{"id":"GO:0045654","count":3},{"id":"GO:0071353","count":3},{"id":"GO:0003290","count":3},{"id":"GO:0045578","count":2}]},{"hash":"1511836966356450112","title":"Tissue Development and Cell Adhesion","description":"Top terms indicate developmental processes across multiple tissues (seminiferous tubule, osteoblasts, chondrocyte differentiation, cerebral cortex layer formation) plus homophilic cell\u2013cell adhesion and related signaling. This suggests a cluster centered on tissue development and cell interactions, with some ancillary metabolism signals. Confidence: Medium","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":3},{"id":"GO:0072520","count":3},{"id":"GO:0021819","count":3},{"id":"GO:0007204","count":3},{"id":"GO:0022900","count":3}]},{"hash":"946343259178975244","title":"Mitochondrial Metabolite Transporters","description":"The GO terms show transport of cofactors and metabolites (pyridoxal phosphate, thiamine pyrophosphate, thiosulfate, phosphate, iron) into mitochondria, along with the malate-aspartate shuttle and mitochondrial ornithine transport, plus mitochondrial-associated processes like apoptotic changes and adaptive thermogenesis. This points to a cluster of proteins involved in mitochondrial transport and energy metabolism.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031921","count":3},{"id":"GO:1990314","count":3},{"id":"GO:0015709","count":3},{"id":"GO:0008637","count":3},{"id":"GO:0043490","count":3}]}]