{"hash":"1887640319502336319","title":"Wnt Signaling and Protein Turnover","description":"The proteins appear to co-function in regulation of signaling pathways, especially Wnt (canonical and planar cell polarity) and NF-kappaB, while also modulating protein abundance through ubiquitin-related processes (deubiquitination and ubiquitin-independent proteasomal degradation). There are links to cell-cycle control (G2/M) and mRNA stability, with some auxiliary signals about stress responses and viral processes. This suggests a cohesive theme of signaling modulation coupled with protein turnover rather than a single enzymatic activity.","confidence":"Medium","size":13,"edges":61,"triangles":145,"max_degree":12,"top_function":null,"members":[{"accession":"XP_035680968.1","go_terms":["GO:1990592","GO:0033146"]},{"accession":"XP_035680969.1","go_terms":["GO:1990592","GO:0033146"]},{"accession":"XP_035689292.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_035688165.1","go_terms":["GO:0032436","GO:0001701","GO:0048142","GO:0043248","GO:0007127","GO:0075525","GO:0000122","GO:0008283","GO:0002188","GO:0035914","GO:1902416","GO:0071033","GO:0006283","GO:0030182","GO:0070196","GO:0000338","GO:0075522","GO:0006446","GO:0034260","GO:0070321","GO:0010972","GO:0048863","GO:0001732","GO:0001731","GO:0048140","GO:0036099","GO:0090054","GO:0090052","GO:0000715","GO:0000973","GO:0006511"]},{"accession":"XP_035685197.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_035657658.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_035659584.1","go_terms":["GO:0000266","GO:0048140","GO:1990182","GO:0001731","GO:0075522","GO:0016559","GO:0043161","GO:0035871","GO:0070452","GO:0070537","GO:0006281","GO:0000338","GO:0006446","GO:0045471","GO:0010387","GO:0035522","GO:0010950","GO:0014067","GO:0000393","GO:0034286","GO:0051726","GO:1902906","GO:0000398","GO:1903894"]},{"accession":"XP_035692204.1","go_terms":["GO:0030011","GO:0031175","GO:0051301","GO:0061163","GO:0030382","GO:0000921","GO:0000281","GO:0016476","GO:1902857","GO:0017157","GO:0031107","GO:0030154","GO:0000278","GO:0051291","GO:0007283","GO:0007056","GO:0051311","GO:0010458","GO:0000917","GO:0032186","GO:0007224","GO:0097271","GO:0000747","GO:0042274","GO:0000055","GO:0042254","GO:1901001","GO:0002181","GO:1903833","GO:0006400","GO:0090529","GO:0007049"]},{"accession":"XP_035671789.1","go_terms":["GO:0018298","GO:0010117","GO:0008218","GO:0006091"]},{"accession":"XP_035678632.1","go_terms":["GO:0020027","GO:0042628","GO:0051561","GO:0050729","GO:0030216","GO:0072378","GO:0043163","GO:0051260","GO:0060445","GO:0048536","GO:0043123","GO:0010838","GO:0042381","GO:0048661","GO:0018153","GO:0043277","GO:0031069","GO:0060662","GO:0031424","GO:0007200","GO:0051482","GO:0001974","GO:0032471","GO:0006058","GO:0006517"]},{"accession":"XP_035674095.1","go_terms":["GO:0018298","GO:0010117","GO:0008218","GO:0006091"]},{"accession":"XP_035687351.1","go_terms":["GO:0010205","GO:0010206","GO:0010304","GO:0030150","GO:0045041","GO:0006515","GO:0051301"]},{"accession":"XP_035667605.1","go_terms":["GO:0001501","GO:0006888","GO:0034498","GO:0043547","GO:0006914","GO:0016358","GO:0045212"]}],"graph":[["XP_035685197.1","XP_035674095.1",0.96],["XP_035685197.1","XP_035678632.1",0.85],["XP_035685197.1","XP_035680968.1",0.844],["XP_035685197.1","XP_035680969.1",0.687],["XP_035685197.1","XP_035689292.1",0.785],["XP_035685197.1","XP_035688165.1",0.862],["XP_035685197.1","XP_035687351.1",0.959],["XP_035685197.1","XP_035692204.1",0.962],["XP_035685197.1","XP_035657658.1",0.682],["XP_035685197.1","XP_035659584.1",0.962],["XP_035685197.1","XP_035667605.1",0.96],["XP_035685197.1","XP_035671789.1",0.96],["XP_035680968.1","XP_035674095.1",0.96],["XP_035680968.1","XP_035678632.1",0.863],["XP_035680968.1","XP_035689292.1",0.978],["XP_035680968.1","XP_035688165.1",0.931],["XP_035680968.1","XP_035687351.1",0.941],["XP_035680968.1","XP_035680969.1",0.914],["XP_035680968.1","XP_035692204.1",0.984],["XP_035680968.1","XP_035657658.1",0.651],["XP_035680968.1","XP_035659584.1",0.934],["XP_035680968.1","XP_035671789.1",0.96],["XP_035674095.1","XP_035680969.1",0.772],["XP_035674095.1","XP_035688165.1",0.908],["XP_035674095.1","XP_035689292.1",0.855],["XP_035674095.1","XP_035692204.1",0.735],["XP_035674095.1","XP_035657658.1",0.962],["XP_035674095.1","XP_035671789.1",0.892],["XP_035680969.1","XP_035678632.1",0.738],["XP_035680969.1","XP_035689292.1",0.969],["XP_035680969.1","XP_035688165.1",0.891],["XP_035680969.1","XP_035687351.1",0.569],["XP_035680969.1","XP_035692204.1",0.984],["XP_035680969.1","XP_035657658.1",0.852],["XP_035680969.1","XP_035659584.1",0.748],["XP_035680969.1","XP_035671789.1",0.891],["XP_035657658.1","XP_035659584.1",0.858],["XP_035657658.1","XP_035667605.1",0.962],["XP_035657658.1","XP_035671789.1",0.698],["XP_035657658.1","XP_035678632.1",0.684],["XP_035657658.1","XP_035687351.1",0.962],["XP_035657658.1","XP_035689292.1",0.628],["XP_035657658.1","XP_035692204.1",0.65],["XP_035689292.1","XP_035687351.1",0.918],["XP_035689292.1","XP_035688165.1",0.844],["XP_035689292.1","XP_035692204.1",0.974],["XP_035689292.1","XP_035659584.1",0.666],["XP_035689292.1","XP_035667605.1",0.961],["XP_035689292.1","XP_035671789.1",0.962],["XP_035692204.1","XP_035671789.1",0.963],["XP_035692204.1","XP_035687351.1",0.54],["XP_035692204.1","XP_035659584.1",0.963],["XP_035692204.1","XP_035667605.1",0.963],["XP_035687351.1","XP_035671789.1",0.961],["XP_035667605.1","XP_035671789.1",0.961],["XP_035667605.1","XP_035688165.1",0.765],["XP_035671789.1","XP_035659584.1",0.858],["XP_035671789.1","XP_035678632.1",0.76],["XP_035671789.1","XP_035688165.1",0.939],["XP_035678632.1","XP_035688165.1",0.567],["XP_035688165.1","XP_035659584.1",0.886]],"all_go_terms":{"GO:0033146":2,"GO:1990592":2,"GO:0060071":3,"GO:0043488":3,"GO:0038061":3,"GO:0046686":3,"GO:0016579":3,"GO:0090090":3,"GO:0010950":4,"GO:0016032":3,"GO:0010499":3,"GO:0038095":3,"GO:0090263":3,"GO:0010043":3,"GO:0050852":3,"GO:0002223":3,"GO:0033209":3,"GO:0061418":3,"GO:0031145":3,"GO:0009651":3,"GO:0051436":3,"GO:0080129":3,"GO:0010972":4,"GO:0031146":3,"GO:0002862":3,"GO:0010363":3,"GO:0051437":3,"GO:0006521":3,"GO:0002479":3,"GO:0070196":1,"GO:0071033":1,"GO:0007127":1,"GO:0070321":1,"GO:0030182":1,"GO:0001732":1,"GO:0006283":1,"GO:0036099":1,"GO:0000715":1,"GO:0043248":1,"GO:0035914":1,"GO:0006511":1,"GO:0002188":1,"GO:0048142":1,"GO:0090054":1,"GO:0048863":1,"GO:0034260":1,"GO:0048140":2,"GO:0000973":1,"GO:1902416":1,"GO:0075525":1,"GO:0001701":1,"GO:0008283":1,"GO:0090052":1,"GO:0001731":2,"GO:0000122":1,"GO:0000338":2,"GO:0075522":2,"GO:0006446":2,"GO:0032436":1,"GO:0034286":1,"GO:0043161":1,"GO:0070537":1,"GO:0070452":1,"GO:1902906":1,"GO:0000266":1,"GO:0016559":1,"GO:0000398":1,"GO:0035871":1,"GO:0014067":1,"GO:0000393":1,"GO:1990182":1,"GO:0010387":1,"GO:0051726":1,"GO:0006281":1,"GO:0045471":1,"GO:1903894":1,"GO:0035522":1,"GO:0051311":1,"GO:0042254":1,"GO:0031107":1,"GO:1901001":1,"GO:0000278":1,"GO:1902857":1,"GO:0061163":1,"GO:0031175":1,"GO:0000921":1,"GO:0002181":1,"GO:0017157":1,"GO:0030382":1,"GO:0010458":1,"GO:0000747":1,"GO:1903833":1,"GO:0007224":1,"GO:0042274":1,"GO:0016476":1,"GO:0097271":1,"GO:0030154":1,"GO:0090529":1,"GO:0000055":1,"GO:0051291":1,"GO:0051301":2,"GO:0007049":1,"GO:0000917":1,"GO:0030011":1,"GO:0032186":1,"GO:0006400":1,"GO:0007056":1,"GO:0000281":1,"GO:0007283":1,"GO:0006091":2,"GO:0018298":2,"GO:0010117":2,"GO:0008218":2,"GO:0060445":1,"GO:0042628":1,"GO:0031424":1,"GO:0018153":1,"GO:0007200":1,"GO:0030216":1,"GO:0031069":1,"GO:0001974":1,"GO:0051260":1,"GO:0042381":1,"GO:0043277":1,"GO:0010838":1,"GO:0051561":1,"GO:0060662":1,"GO:0048661":1,"GO:0032471":1,"GO:0072378":1,"GO:0020027":1,"GO:0006517":1,"GO:0051482":1,"GO:0050729":1,"GO:0048536":1,"GO:0006058":1,"GO:0043123":1,"GO:0043163":1,"GO:0010206":1,"GO:0010304":1,"GO:0045041":1,"GO:0006515":1,"GO:0030150":1,"GO:0010205":1,"GO:0034498":1,"GO:0043547":1,"GO:0006914":1,"GO:0001501":1,"GO:0045212":1,"GO:0006888":1,"GO:0016358":1},"recipe_readded":[]}