[{"hash":"1928696835825832549","title":"Innate Immune Recognition and Signaling","description":"The top GO terms are dominated by innate immune processes: phagocytosis recognition, leukocyte tethering/rolling, basophil activation, stimulatory C-type lectin receptor signaling, and cellular response to fungal origin. These strongly suggest a cluster centered on innate immune recognition and signaling, with some developmental terms (mesonephric/metanephric development, lymph vessel morphogenesis, cartilage condensation) that may reflect broader tissue context or pleiotropy but do not outweigh the immune-related signals. Confidence: Medium","confidence":"","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":29},{"id":"GO:0006910","count":29},{"id":"GO:0072218","count":29},{"id":"GO:0050901","count":29},{"id":"GO:0036303","count":29}]},{"hash":"1674094829052188340","title":"Lectin pathway complement activation","description":"Top GO terms are dominated by complement activation via the lectin pathway (GO:0001867) with 21 hits, along with innate immune responses such as cellular response to fungal origin, leukocyte tethering/rolling, and phagocytosis recognition. These signals together indicate an innate immune activation against fungal components, involving leukocyte recruitment and opsonization. Some developmental terms (e.g., metanephric development) appear as secondary annotations but do not define the core function. Overall, the strongest theme is lectin pathway\u2013driven complement activation and innate immunity.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0001867","count":21},{"id":"GO:0071226","count":15},{"id":"GO:0050901","count":15},{"id":"GO:0010572","count":15},{"id":"GO:0072218","count":14}]},{"hash":"551528255327170940","title":"Vascular Inflammation and Coagulation","description":"The cluster is dominated by GO terms for inflammatory responses (inflammation, response to LPS, IL-6 regulation) and blood coagulation, with additional signals pointing to vascular remodeling (endothelial proliferation and tissue development). This suggests a cohesive module where immune activation interfaces with coagulation and vascular tissue dynamics, justifying a label centered on inflammation and coagulation in a vascular context.","confidence":"High","size":29,"edges":16,"triangles":5,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":7},{"id":"GO:0032496","count":7},{"id":"GO:0007596","count":6},{"id":"GO:0050728","count":6},{"id":"GO:0032675","count":5}]},{"hash":"279461043856984970","title":"Metal Ion Homeostasis and Transcriptional Regulation","description":"The cluster is enriched for metal ion transport/homeostasis (potassium, magnesium, manganese) and for DNA-templated transcription and its regulation, suggesting a core function in maintaining ion balance while controlling gene expression. While other terms hint at lipid metabolism and circadian regulation, the strongest cohesive signal links ion homeostasis with transcriptional control.","confidence":"Medium","size":29,"edges":70,"triangles":43,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006813","count":8},{"id":"GO:0010960","count":7},{"id":"GO:0030026","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0006355","count":7}]},{"hash":"698213877232613648","title":"Acetyl-CoA and fatty acid metabolism","description":"The cluster\u2019s top GO terms strongly point to lipid metabolism and acetyl-CoA\u2013related pathways, including acetyl-CoA biosynthesis from acetate, pyruvate fermentation to acetate, fatty acid biosynthesis, medium-chain fatty-acyl-CoA metabolism, and transport. These collectively suggest a coherent theme around acetyl-CoA\u2013driven lipid synthesis and utilization, with a few peripheral terms (e.g., seed germination, siderophore biosynthesis) that appear noisy or context-specific but do not override the central lipid-metabolism signal.","confidence":"High","size":29,"edges":10,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0019427","count":11},{"id":"GO:0010124","count":11},{"id":"GO:1902987","count":11},{"id":"GO:0019654","count":11},{"id":"GO:0006633","count":11}]},{"hash":"1491511046638317047","title":"Immune Response and Inflammation","description":"The top GO terms cluster around immune activity\u2014B cell proliferation in immune response, innate and inflammatory responses, and defense against virus\u2014plus cytokine regulation. A few terms relate to development or extracellular matrix, but the dominant theme is immune defense and inflammation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002322","count":8},{"id":"GO:0006954","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":7},{"id":"GO:0045410","count":6}]},{"hash":"441243939139686580","title":"HGF/PDGF Signaling and Fibrinolysis Regulation","description":"The top GO terms cluster around hepatocyte growth factor receptor signaling, PDGF receptor signaling, and responses to HGF, along with plasminogen activation and both positive and negative regulation of fibrinolysis, plus coagulation. This points to a cohesive role for growth-factor\u2013receptor signaling interfacing with coagulation/fibrinolysis pathways, with additional calcium signaling connections.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051918","count":18},{"id":"GO:0051281","count":16},{"id":"GO:0014068","count":15},{"id":"GO:0007223","count":15},{"id":"GO:0048012","count":14}]},{"hash":"897931634009050643","title":"GPCR-Driven cAMP/cGMP Signaling","description":"The top GO terms cluster around G protein-coupled receptor signaling pathways that regulate second messengers like cAMP and cGMP, including adenylate cyclase-activating adrenergic signaling, adenosine receptor signaling, and guanylyl cyclase pathways, all pointing to intracellular signal transduction downstream of GPCR activity. Some terms touch on downstream processes such as hypoxia detection and transcription regulation, but the central theme remains GPCR-mediated second messenger production and signaling.","confidence":"High","size":29,"edges":6,"triangles":4,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0071880","count":18},{"id":"GO:0006355","count":18},{"id":"GO:0070483","count":18},{"id":"GO:0006171","count":18},{"id":"GO:1904322","count":18}]},{"hash":"94937534179653329","title":"Mast cell degranulation and inflammatory signaling","description":"The top GO terms cluster around innate immune responses and signaling leading to exocytosis and mediator release, including regulation of mast cell degranulation, calcium-dependent exocytosis, IL-1 signaling, JNK cascade, PI3K-related signaling, and ephrin receptor pathways. While DNA replication and mitotic cycle terms appear among the list, the dominant theme is immune signaling and secretion, especially in mast cells. This suggests the proteins behave as a unit in inflammatory signaling and granule release rather than core cell-cycle machinery alone.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":24},{"id":"GO:0000278","count":21},{"id":"GO:0045087","count":20},{"id":"GO:0031532","count":19},{"id":"GO:0043304","count":19}]},{"hash":"595160324188744891","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0034975","count":2},{"id":"GO:0071031","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0010587","count":1}]},{"hash":"2264634837038487711","title":"Ribosome biogenesis and RNA processing","description":"The proteins show strong representation of rRNA maturation and ribosome assembly (maturation of 5.8S and LSU rRNA; preribosome large subunit assembly; ribosomal large subunit assembly) together with mRNA splicing and transcription-related regulation (spliceosome-related splicing, regulation of transcription, chromatin remodeling). This suggests a cohesive theme around RNA processing and ribosome biogenesis, with transcription/chromatin dynamics linked to ribosome production.","confidence":"High","size":29,"edges":8,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0006367","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0000463","count":2}]},{"hash":"1082561802852105641","title":"Female reproductive development and lipid hormone biosynthesis","description":"The cluster is dominated by terms for uterus and female gonad development and digestive tract development, with multiple lipid/hormone pathways (prostaglandin, oxylipin, aldosterone) and hormone-related responses (vitamin D). This suggests a developmental program with distinct endocrine/lipid signaling components rather than a single narrow function.","confidence":"Medium","size":29,"edges":5,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060065","count":9},{"id":"GO:0008585","count":9},{"id":"GO:0048565","count":9},{"id":"GO:0033280","count":9},{"id":"GO:0071603","count":9}]},{"hash":"2064648194673404498","title":"Rho GTPase signaling and cell migration","description":"This cluster centers on small GTPase signaling (especially Rho), with multiple terms for regulation of GTPase activity, cell migration, podosome assembly, endocytosis, and epithelial polarity. Together these reflect cytoskeletal remodeling and adhesion processes that drive cell movement, particularly in immune and epithelial contexts, making \"Rho GTPase signaling and cell migration\" a representative label.","confidence":"High","size":29,"edges":71,"triangles":46,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007264","count":7},{"id":"GO:0016477","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0061000","count":6},{"id":"GO:0007507","count":6}]},{"hash":"855261491422389359","title":"Embryonic skeletal and organ development","description":"The top GO terms point to developmental processes affecting bone (bone mineralization, chondrocyte differentiation) and organogenesis (lung alveolus development, embryonic digestive tract development). While some terms are more peripheral (amino acid biosynthesis, Golgi transport, antibiotic response), the dominant pattern supports embryonic tissue development and skeletal formation as the cluster\u2019s theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030282","count":4},{"id":"GO:0042997","count":4},{"id":"GO:0019284","count":3},{"id":"GO:0019509","count":3},{"id":"GO:0016310","count":3}]},{"hash":"2074313862724973424","title":"Diverse transcription and signaling regulators","description":"This cluster shows a mix of terms tied to transcription (DNA-templated transcription), various signaling pathways (including GPCR-related signaling and cardiac action potential regulation), and diverse differentiation and stress responses (fat cell differentiation, response to pain, muscle stretch, foam cell differentiation, insulin-related processes). The combination suggests proteins that broadly regulate gene expression and signaling across different tissues rather than a single, cohesive pathway. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0048265","count":9},{"id":"GO:0007205","count":9},{"id":"GO:0098907","count":9},{"id":"GO:0032212","count":8}]},{"hash":"1212207024789649819","title":"Ribosome biogenesis and translation","description":"The proteins are dominated by GO terms for ribosome assembly and function (ribosome biogenesis, ribosomal subunit biogenesis, export from nucleus) and for translation (translation, cytoplasmic translation), with supporting tRNA modification. This pattern points to a cluster centered on ribosome construction and protein synthesis, with cell cycle terms likely reflecting growth coupling rather than a primary function. ","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0006412","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0007049","count":5},{"id":"GO:0002181","count":5}]},{"hash":"634919686956102576","title":"Cytoskeletal remodeling and cell adhesion","description":"Predominant theme is actin cytoskeleton remodeling and mechanotransduction, highlighted by filopodium and stress fiber assembly, and adhesion-dependent cell spreading. Other terms (ER-Golgi transport, mitochondrial fission, GABAergic signaling, apoptosis) are present but less central, so the label captures the core function of this cluster without overreaching.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0071260","count":6},{"id":"GO:0046847","count":6},{"id":"GO:1900026","count":6},{"id":"GO:0006888","count":5},{"id":"GO:0051932","count":5}]},{"hash":"1008759706938637292","title":"Embryonic Development and Organ Differentiation","description":"The top GO terms point to broad developmental and differentiation processes, including left/right pattern formation, pancreatic and endocrine system development, placental and trophoblast differentiation, cartilage morphogenesis, and EMT in endocardial cushion formation. These collectively suggest proteins involved in embryonic development and subsequent organogenesis rather than a single specific pathway, making a label centered on developmental patterning and tissue differentiation appropriate.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0060972","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060707","count":5}]},{"hash":"111755231034604476","title":"ECM remodeling and vesicle trafficking","description":"This cluster is characterized by GO terms related to extracellular matrix disassembly and bone development (ECM remodeling) alongside several vesicle trafficking processes (intralumenal vesicle formation, endocytic recycling, and endosome-to-lysosome transport) and associated lipid metabolism (cholesterol and phosphatidic acid biosynthesis). Together these terms suggest a functional theme around remodeling of the cell surface/ECM coupled with membrane trafficking and lipid-mediated membrane dynamics.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060348","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0022617","count":4},{"id":"GO:0008203","count":3},{"id":"GO:0032120","count":3}]},{"hash":"813320702212445381","title":"Tissue morphogenesis and angiogenesis","description":"Top GO terms indicate morphogenetic processes across diverse tissues, including axonogenesis, lymph vessel and kidney tubule morphogenesis, nipple and lung development, and angiogenesis. This pattern suggests the cluster reflects broader developmental remodeling rather than a single pathway, with angiogenesis as a prominent theme alongside neural and organ morphogenesis. Confidence: High","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007409","count":10},{"id":"GO:0006469","count":10},{"id":"GO:0014068","count":9},{"id":"GO:0036303","count":9},{"id":"GO:0072237","count":9}]},{"hash":"1138470916059403787","title":"Embryogenesis and Hematopoietic Differentiation","description":"GO terms point to in utero embryonic development and multiple hematopoietic differentiation processes (granulocytes, erythrocytes, megakaryocytes), plus neuronal maturation and transcriptional regulation, suggesting a developmental module that governs lineage specification during embryogenesis.","confidence":"Medium","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":10},{"id":"GO:0021983","count":9},{"id":"GO:0000122","count":8},{"id":"GO:0032496","count":8},{"id":"GO:0043046","count":7}]},{"hash":"1376517855663083618","title":"Metabolic Biosynthesis and Energy Pathways","description":"The top GO terms point to a mix of biosynthetic processes (antibiotic, clavulanic acid, poly-hydroxybutyrate) and various catabolic pathways (xanthine, propylene, herbicide-related 2,4-dichlorophenoxyacetic acid), plus a mitochondrial electron transport step (NADH to ubiquinone). This suggests a cluster of enzymes involved in both energy metabolism and metabolite biosynthesis/turnover, with a possible regulatory component. While some terms are heterogeneous, the unifying theme is metabolism\u2014biosynthesis and degradation/processing of metabolites\u2014rather than a single, cohesive function.","confidence":"Medium","size":29,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0045329","count":5},{"id":"GO:0006120","count":4},{"id":"GO:0006151","count":4}]},{"hash":"2057482440817589336","title":"RNA and protein methylation enzymes","description":"The top GO terms are dominated by methylation activities (N-terminal peptidyl-glycine methylation; rRNA methylation; RNA guanine-N7 methylation; peptidyl-lysine dimethylation; peptidyl-arginine methylation), pointing to a cluster of methyltransferases acting on RNA and proteins. Additional terms like light-independent chlorophyll biosynthesis, nodulation, and stress responses are present but less central. This suggests the core function of the cluster centers on methylation chemistry rather than a single metabolic or signaling pathway.","confidence":"High","size":29,"edges":103,"triangles":156,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0018013","count":11},{"id":"GO:0031167","count":10},{"id":"GO:0036265","count":10},{"id":"GO:0046690","count":10},{"id":"GO:0036068","count":10}]},{"hash":"366784608624321843","title":"Unknown","description":"The top terms cover a wide range of metabolic and biosynthetic processes, including steroid hormone metabolism, pigment biosynthesis, vitamin/phytochemicals turnover, and even plant- and bacterial-specific pathways, along with a developmental process (lung development). This broad and heterogeneous mix makes it difficult to identify a single, cohesive function for the cluster. ","confidence":"","size":29,"edges":162,"triangles":392,"max_degree":22,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":26},{"id":"GO:0055114","count":26},{"id":"GO:0030324","count":23},{"id":"GO:0009710","count":23},{"id":"GO:0042376","count":23}]},{"hash":"76488752524013026","title":"Diverse membrane solute transporters","description":"The top GO terms are centered on transmembrane transport with multiple substrate categories, including sugars (galactose, fucose), nitrate/nitrite, xenobiotics, and even neurotransmitter loading into synaptic vesicles. This pattern points to a cluster of membrane transporter proteins that move a variety of solutes across membranes, rather than a single substrate class or metabolic enzyme. The breadth of substrates represented supports labeling the group as diverse transporters rather than a narrow functional category.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0055085","count":5},{"id":"GO:0098700","count":5},{"id":"GO:0006004","count":5},{"id":"GO:0035435","count":5},{"id":"GO:0015757","count":5}]},{"hash":"2084290744507932870","title":"Neural ion transport and synaptic signaling","description":"This cluster is dominated by GO terms for ion transmembrane transport (potassium, sodium, calcium), excitatory postsynaptic potentials, and receptor clustering, all pointing to neuronal signaling and synaptic function. Behavioral and memory-related terms (phototaxis, long-term memory, responses to ethanol/amphetamine) support a neural circuit theme, though an angiogenesis term may reflect broader multifunctionality of included proteins.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0048149","count":3},{"id":"GO:0043113","count":3}]},{"hash":"287790685132660537","title":"Biosynthesis and methylation pathways","description":"The GO terms show a cohesive theme of biosynthetic processes (biotin, antibiotic, phosphatidylcholine, ubiquinone, sterol) alongside methylation-related activities (RNA guanine-N7 methylation, mRNA capping, tRNA methylation, histone methylation), suggesting a cluster focused on biomolecule biosynthesis coupled with methylation modifications.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0009102","count":16},{"id":"GO:0017000","count":16},{"id":"GO:0016049","count":15},{"id":"GO:0036265","count":15},{"id":"GO:0006370","count":15}]},{"hash":"258060019085800833","title":"Neural Synapse Formation and Cell-Matrix Adhesion","description":"The cluster is enriched for synapse assembly and cell-matrix adhesion, suggesting roles in neural connectivity and ECM interactions. Other terms (pain signaling, VEGF response, immune cues) are present but the dominant theme is synaptic adhesion and signaling.","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":11},{"id":"GO:0055114","count":11},{"id":"GO:0007160","count":11},{"id":"GO:0032495","count":10},{"id":"GO:0030216","count":10}]},{"hash":"1300326604286533634","title":"Nervous system development and myelination","description":"The top GO terms cluster around neural development and wiring: paranodal junction assembly, axonal fasciculation, axon extension, myelination, and synapse assembly, all core to axon growth, guidance, and myelination. Signaling terms (integrin-mediated and PI3K pathways) support these processes. The presence of otolith morphogenesis and mechanosensory sound detection suggests sensory system (inner ear) development as well. An innate immune response term may reflect glial involvement in the nervous system. Together, these indicate a cluster centered on nervous system development, axon wiring, and sensory system formation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030913","count":7},{"id":"GO:0007413","count":6},{"id":"GO:0050910","count":6},{"id":"GO:0042552","count":5},{"id":"GO:0032474","count":5}]},{"hash":"929660596530030494","title":"COPI-mediated ER-Golgi transport","description":"The cluster is dominated by GO terms for COPI-coated vesicle budding, COPI coating of Golgi vesicles, ER-to-Golgi transport, ER protein retention and export regulation, and Golgi ribbon formation, all pointing to a cohesive role in COPI-mediated trafficking between the ER and Golgi. A related term on amyloid-beta regulation aligns with secretory-pathway processing of amyloid precursor proteins, reinforcing the trafficking theme, though a few developmental terms appear incidental. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902003","count":3},{"id":"GO:0035964","count":3},{"id":"GO:0048205","count":3},{"id":"GO:0090161","count":3},{"id":"GO:0002121","count":3}]},{"hash":"1783410101256891351","title":"Glutamatergic Synapse Signaling and Plasticity","description":"The cluster is dominated by GO terms tied to excitatory neurotransmission: sodium and potassium ion transport across the neuronal membrane, ionotropic glutamate receptor signaling, and the generation of excitatory postsynaptic potentials. Several terms also reference regulation of long-term and short-term synaptic plasticity, pointing to activity-dependent changes at glutamatergic synapses. While a few terms (response to ethanol, fungicide, lithium) are broader or stress-related, the core signal centers on glutamate receptor\u2013mediated signaling and ion flux at excitatory synapses. Therefore, the cluster likely represents proteins functioning in glutamatergic neurotransmission and synaptic plasticity.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":7},{"id":"GO:0060992","count":5},{"id":"GO:0050806","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0071805","count":5}]},{"hash":"1265018602238358340","title":"Interferon-responsive innate immunity and cell cycle regulation","description":"The cluster is dominated by GO terms for cellular response to type I interferon and innate immune response, indicating antiviral signaling as a core theme. Additional terms point to cell cycle regulation (mitotic transitions) and ubiquitin-mediated protein control (K11-linked ubiquitination, ER-associated degradation), suggesting a linking of antiviral responses with protein quality control and cell cycle processes. Some terms are obsolete, but the prevailing connections revolve around interferon-driven immunity and related proteostasis mechanisms.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0071357","count":17},{"id":"GO:0051301","count":17},{"id":"GO:0006463","count":15},{"id":"GO:0050689","count":15},{"id":"GO:0007091","count":15}]},{"hash":"2245163749947894203","title":"Immune signaling and inflammatory regulation","description":"The top GO terms cluster around negative regulation of NF-kappaB signaling, TNF production, macrophage differentiation, and T cell homeostasis, all pointing to immune/inflammatory pathway control. Additional terms on DNA damage checkpoints and regulation of necroptosis suggest links to cellular stress responses that intersect immune signaling. A few terms like response to cocaine or glucose import regulation appear peripheral but may reflect broader signaling or metabolic crosstalk in immune contexts. Overall, the proteins seem enriched for regulators of immune/inflammatory pathways, especially NF-kB and TNF-related processes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043124","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0000077","count":4},{"id":"GO:0032760","count":4},{"id":"GO:1901740","count":3}]},{"hash":"1605222788050231245","title":"Axon guidance and synapse assembly in neurons","description":"The cluster's top GO terms center on neuronal differentiation, axon guidance, paranodal/juxtaparanode specialization, and synapse assembly, with cell adhesion featuring prominently. This points to coordinated neuronal development and wiring, including guidance cues (semaphorin-plexin) and junction formation, which justifies naming it around axon guidance and synapse formation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021859","count":16},{"id":"GO:1905065","count":16},{"id":"GO:0071205","count":16},{"id":"GO:0051965","count":16},{"id":"GO:0030913","count":16}]},{"hash":"731216158234614930","title":"Developmental morphogenesis and organ formation","description":"GO terms indicate embryonic development and organogenesis processes, including placental/trophoblast differentiation, left-right patterning, endocrine system development, EMT in heart cushion formation, cartilage morphogenesis, and nervous system development. This cohesive set points to developmental differentiation and tissue morphogenesis rather than metabolism or signaling, justifying the label.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0060972","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4}]},{"hash":"1045580359817563276","title":"Innate Immune Signaling and Cytokine Production","description":"This cluster is enriched for innate immune response terms, including defense against pathogens, cytokine and chemokine production, TLR/MyD88 signaling, and IL-12 responses, indicating a group of proteins involved in pathogen recognition and cytokine-mediated immune signaling. Some terms are obsolete but collectively point to innate immunity and inflammatory signaling.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0002374","count":4},{"id":"GO:0045087","count":4}]},{"hash":"1085706592737979629","title":"Innate inflammatory signaling and TNF/NF-kB response","description":"The top GO terms cluster around innate immunity and inflammatory processes, including inflammatory response, positive regulation of TNF production, innate immune response, lipopolysaccharide signaling, and positive regulation of canonical NF-kappaB signaling, plus related pathways like extrinsic apoptotic signaling and immune-related organ development (spleen). This suggests a cohesive theme of innate immune activation and inflammatory signaling, with some terms reflecting broad stress responses that can accompany inflammation. Overall, the cluster likely represents proteins involved in innate immune signaling and inflammatory responses.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":5},{"id":"GO:0032760","count":5},{"id":"GO:0048536","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0031663","count":4}]},{"hash":"972599690949236363","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0071260","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0006898","count":4},{"id":"GO:0048265","count":4}]},{"hash":"835401606624051285","title":"Xenobiotic and Hormone Metabolism","description":"The GO terms point to processing of diverse small molecules\u2014xenobiotics, bile acids, catecholamines, and thyroid hormones\u2014as well as glycosaminoglycan-related biosynthesis/metabolism. While heart development and innate immune terms appear as outliers, the dominant signal is broad metabolic processing of various compounds. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0030573","count":3},{"id":"GO:0006044","count":3},{"id":"GO:0015015","count":3}]},{"hash":"587544772170906767","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":345,"triangles":2541,"max_degree":27,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010610","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0033129","count":5},{"id":"GO:0060291","count":5},{"id":"GO:0043065","count":5}]},{"hash":"135073076881544413","title":"Renal morphogenesis and immune signaling","description":"The top GO terms include multiple kidney development processes (mesonephric duct development, metanephric proximal tubule and ascending limb development) along with lymph/vessel morphogenesis, plus immune-related activities (complement activation, phagocytosis recognition, leukocyte tethering/rolling, basophil activation). This suggests a cluster of proteins involved in kidney organogenesis with concurrent modulation of immune interactions.","confidence":"Medium","size":28,"edges":153,"triangles":282,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":26},{"id":"GO:0001867","count":26},{"id":"GO:0072177","count":25},{"id":"GO:0006910","count":25},{"id":"GO:0072218","count":25}]},{"hash":"965064707976870857","title":"Neurovascular development and synapse assembly","description":"This cluster centers on neural-related processes (synapse assembly, memory, cell adhesion) alongside vascular-related regulation (vasoconstriction, blood vessel remodeling) and developmental signaling (Notch pathway modulation). The convergence of neural and vascular development terms suggests a neurovascular theme, where both systems are coordinated during development and remodeling, supported by Notch signaling involvement.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":18},{"id":"GO:0045907","count":14},{"id":"GO:0045746","count":14},{"id":"GO:0051965","count":14},{"id":"GO:0007157","count":14}]},{"hash":"1344377629538911846","title":"Neural axon guidance and paranodal localization","description":"The cluster is dominated by terms related to axon guidance (commissural neuron axon guidance, axon extension), and precise protein localization to paranodal/juxtaparanodal regions of axons, plus a related term on synaptic vesicle endocytosis. Retina layer formation also aligns with neural development, supporting a neural/axon guidance theme, while vascular-related terms may be less central noise. Overall, a neural development and axon guidance focus best fits the group.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0071679","count":14},{"id":"GO:0071205","count":14},{"id":"GO:1900242","count":14},{"id":"GO:0002175","count":14},{"id":"GO:0010842","count":14}]},{"hash":"690858754901974458","title":"Ubiquitin-Dependent Proteolysis and Stress Response","description":"The cluster is dominated by ubiquitin-dependent degradation pathways (ERAD, SCF-proteasome), with specific ubiquitin linkages (K63, K11) and positive regulation of ubiquitination, implying a core ubiquitin-proteasome module. Supporting terms include cadmium ion response, oxidative stress-induced neuronal apoptosis, circadian rhythm regulation, and mitotic G1 DNA damage checkpoint signaling, which together suggest roles in protein turnover coupled to stress signaling and cell-cycle control. Therefore, a concise label emphasizing ubiquitin-mediated proteolysis and associated stress responses is appropriate.","confidence":"High","size":28,"edges":93,"triangles":105,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0030433","count":16},{"id":"GO:0031146","count":14},{"id":"GO:0031571","count":13},{"id":"GO:1902916","count":13}]},{"hash":"487284416282805532","title":"Development and Cell Division Regulators","description":"This cluster shows enrichment for multicellular organism development and skeletal development, along with mitotic cell cycle and spindle assembly terms, suggesting proteins that coordinate developmental growth with cell proliferation and gene regulation. Transcriptional regulation and stress-related apoptotic signaling appear as supporting themes, but the core pattern is development-associated proliferation and mitosis control.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0001501","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0090307","count":4},{"id":"GO:0008284","count":4}]},{"hash":"549798774525330249","title":"Neuronal development and synaptic vesicle signaling","description":"The top GO terms cluster around brain development, synaptic signaling (reelin pathway, vesicle exocytosis), Rho-mediated cytoskeletal regulation, and phosphoinositide signaling, all central to neuronal maturation and synaptic function. While some terms relate to broader trafficking or cross-species processes, the predominant theme is neuronal development and synaptic communication, making this label representative of the cluster.","confidence":"Medium","size":28,"edges":206,"triangles":569,"max_degree":20,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007420","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0038026","count":7},{"id":"GO:0006886","count":7},{"id":"GO:2000300","count":7}]},{"hash":"2179320638322562247","title":"Neural development and dendrite morphogenesis","description":"These proteins show a strong enrichment for nervous system development, dendrite morphogenesis, and related signaling pathways (ephrin signaling, JNK cascade) as well as actin cytoskeleton dynamics and inner ear development, which together point to neural differentiation and neuronal connectivity. While a few immune-related terms appear, the dominant theme is neural development.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043552","count":25},{"id":"GO:0006813","count":25},{"id":"GO:0050852","count":25},{"id":"GO:0048813","count":25},{"id":"GO:0007399","count":25}]},{"hash":"105123061351339434","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":29,"triangles":11,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":7},{"id":"GO:0000472","count":6},{"id":"GO:0000480","count":6},{"id":"GO:0002188","count":6},{"id":"GO:0001731","count":6}]},{"hash":"1736035274230850880","title":"Axon Guidance and Connective Tissue Remodeling","description":"Top GO terms cluster around axon extension and fasciculation, plus collagen fibril organization, pointing to neural development intertwined with extracellular matrix remodeling. Related morphogenesis terms further support a connective-tissue development theme, with ancillary immune/hormone response signals. Confidence: Medium","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048846","count":24},{"id":"GO:0030199","count":23},{"id":"GO:0045087","count":23},{"id":"GO:0060658","count":23},{"id":"GO:0060427","count":23}]},{"hash":"2157359588148276340","title":"Innate antiviral and interferon response","description":"The top GO terms are strongly centered on innate immunity and antiviral signaling (innate immune response; cellular response to type I interferon; cellular response to exogenous dsRNA; negative regulation of defense response to virus by host), indicating a cluster focused on antiviral defense mechanisms. A few terms related to cell division and prostate development appear but do not define the main theme. Overall, the dominant signal supports labeling this cluster as innate antiviral/interferon\u2013mediated immunity.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0071357","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0071360","count":5},{"id":"GO:0046661","count":4}]},{"hash":"23996646179880634","title":"RNA processing and translation","description":"This cluster shows strong enrichment for translation and rRNA processing (GO:0006412, GO:0006364, GO:0000462), pointing to ribosome biogenesis and RNA maturation. Additional RNA-related terms (RISC complex assembly, miRNA regulation, RNA editing) indicate broader RNA metabolism. Overall, the dominant signal is RNA biology centered on translation and ribosome production.","confidence":"High","size":28,"edges":377,"triangles":3250,"max_degree":27,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":20},{"id":"GO:0006364","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0006407","count":4}]},{"hash":"2055001186832389703","title":"Craniofacial development and ECM remodeling","description":"The top GO terms center on multicellular organism development and embryospecific craniofacial processes, including cranial skeleton morphogenesis and hard palate development, with collagen fibril organization and proteolysis pointing to extracellular matrix remodeling in facial structures. While there are still terms related to transcription regulation and immune response, the strongest theme ties to craniofacial morphogenesis and ECM dynamics during development, suggesting the cluster aggregates proteins involved in shaping facial features and ECM remodeling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0042511","count":3},{"id":"GO:0032968","count":2},{"id":"GO:0000012","count":2}]},{"hash":"1083359914145794014","title":"Neural development and ciliogenesis with ectodermal differentiation","description":"This cluster is dominated by neural-development related GO terms (brain development, neuronal stem cell maintenance, GABAergic synaptic transmission) and ciliogenesis (cilium assembly), suggesting a theme centered on neural differentiation and signaling. The presence of keratinization and pigmentation hints at ectodermal differentiation, consistent with neural crest derivatives. Some vascular terms (blood vessel maturation, endothelial delamination) appear less tightly linked but may reflect shared developmental programs or cell-type interactions. Overall, the label emphasizes neural development with supporting ciliary and ectodermal signals.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":4},{"id":"GO:0001955","count":3},{"id":"GO:0031424","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0008584","count":2}]},{"hash":"604173851632597742","title":"Bacterial cell wall turnover and sporulation","description":"This cluster\u2019s top GO terms cluster around peptidoglycan biosynthesis and catabolism, cell wall organization/remodeling, and regulation of cell shape, with Sporulation and chitin-related responses also appearing. The combination points to proteins involved in cell wall remodeling and sporulation processes typical of bacteria (e.g., Bacillus spp.), suggesting a cohesive functional theme despite mixed terms. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016998","count":2},{"id":"GO:0009252","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0008360","count":2},{"id":"GO:0030435","count":2}]},{"hash":"801736334654838864","title":"Neuronal Sensory Perception and Synaptic Plasticity","description":"Top GO terms cluster around neural sensing (touch, pain, olfactory learning, taste aversion) and synaptic plasticity (EPSP, long-term regulation), with receptor internalization supporting signaling dynamics. A couple terms (fungicide response, propylene metabolism) are less directly tied but do not outweigh the prominent theme of sensory processing and learning-related plasticity.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0050975","count":9},{"id":"GO:0060079","count":9},{"id":"GO:0048169","count":9},{"id":"GO:0060134","count":9},{"id":"GO:0001661","count":8}]},{"hash":"439036160651115916","title":"Phosphatase-regulated MAPK and mitotic signaling","description":"This cluster centers on negative regulation of MAPK/ERK signaling and peptidyl-tyrosine dephosphorylation, plus multiple mitotic processes (spindle pole localization, actomyosin contractile ring maturation, chromatid biorientation) and CDK activity control. The common thread appears to be phosphatase-driven modulation of signaling pathways that coordinate cell proliferation and timing, with additional links to neuronal synapse organization and circadian regulation.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":23},{"id":"GO:0000200","count":23},{"id":"GO:0050860","count":23},{"id":"GO:0035335","count":21},{"id":"GO:1902406","count":20}]},{"hash":"2112282615494093598","title":"Mitochondrial Transport and Energy Regulation","description":"The top terms show a clear mitochondrial focus: regulation of mitochondrial membrane potential and multiple mitochondrial transmembrane transport processes (ATP, citrate, ornithine, thiosulfate), with supporting signals of metabolic regulation (insulin response, amino acid starvation) and liver-related context, pointing to a cohesive theme of mitochondrial transport coupled to energy/metabolic control.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051881","count":5},{"id":"GO:0032869","count":4},{"id":"GO:0000002","count":3},{"id":"GO:0015886","count":3},{"id":"GO:0000066","count":3}]},{"hash":"183893203025462177","title":"Nervous system development and synapse organization","description":"Based on the top GO terms, the cluster predominantly centers on neural development, axon guidance (ROBO pathway), paranode protein localization, myelination, and synapse assembly/organization, with Rho-signaling implications for cytoskeletal dynamics. Some terms like angiogenesis and kidney development are present but represent a weaker signal compared to the neural-focused terms.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0030199","count":3}]},{"hash":"1229790971463135955","title":"Embryonic Development and Organ Morphogenesis","description":"The cluster centers on developmental processes: in utero embryonic development, pituitary gland development, embryonic eye and lung morphogenesis, and stem cell proliferation, all pointing to organogenesis. The presence of transcription-related terms (RNA polymerase II transcription and its negative regulation) suggests this gene set is involved in orchestrating developmental transcription programs. The combination of progenitor activity and organ morphogenesis supports a concise label focusing on embryonic development and tissue formation.","confidence":"High","size":28,"edges":112,"triangles":71,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":11},{"id":"GO:0001701","count":9},{"id":"GO:0000122","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0045648","count":8}]},{"hash":"719649374164331271","title":"Calcium-Linked Cardiac and Neural Signaling","description":"This cluster aggregates GO terms tied to cardiac function (cardiac muscle contraction, SA node action potential, heart development) and calcium transport, plus neural signaling processes (neurotransmitter secretion, excitatory postsynaptic potential, synaptic potentiation). The common thread appears to be calcium-dependent signaling that governs excitation in both heart and neuronal systems, with some overlap in protein phosphorylation dynamics.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060048","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0098907","count":5},{"id":"GO:0043388","count":4},{"id":"GO:0007507","count":4}]},{"hash":"1958392743410308810","title":"Neural synapse and bone development","description":"This cluster is dominated by GO terms related to neural connectivity and axon domain organization (positive regulation of synapse assembly, paranodal junction assembly, juxtaparanode localization, cell-cell adhesion) alongside bone formation and skeletal development (ossification, skeletal system development, BMP signaling). The co-occurrence of neural and skeletal terms suggests proteins involved in coordinating neural development with bone maturation, likely via shared signaling pathways. Therefore, Neural synapse and bone development best captures the core theme.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":20},{"id":"GO:0007275","count":18},{"id":"GO:0001501","count":18},{"id":"GO:0048661","count":18},{"id":"GO:0007156","count":18}]},{"hash":"520007823577249884","title":"Axon guidance and neural crest migration","description":"The enriched GO terms center on axon pathfinding in the peripheral nervous system, including sympathetic and branchio-motor neuron projection, semaphorin-plexin signaling, and neural crest\u2013driven migration. Terms for trigeminal nerve organization and paranodal/juxtaparanodal junctions further support a neural development and peripheral axon maturation theme. Together, these suggest a cluster of proteins involved in axon guidance and neural crest\u2013derived peripheral nerve development.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0097490","count":18},{"id":"GO:0021785","count":18},{"id":"GO:1902287","count":18},{"id":"GO:0021637","count":18},{"id":"GO:0036486","count":18}]},{"hash":"2032791301675683361","title":"Multitissue Developmental Differentiation","description":"This cluster's GO terms point to developmental and differentiation processes across multiple tissues (brain, bone, pancreas, endocrine system) and roles in cardiac morphogenesis (EMT related to endocardial cushion formation) and left-right patterning. While there are some signaling-related terms (GTPase regulation), the overall theme is broad developmental regulation rather than a single pathway or tissue-specific function, justifying a generic \u201cdevelopmental differentiation\u201d label.","confidence":"Medium","size":28,"edges":34,"triangles":0,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0060012","count":2}]},{"hash":"1756765563319960227","title":"Ubiquitin-Mediated Degradation and NF-\u03baB/TNF Signaling","description":"The top GO terms indicate strong enrichment for ubiquitin-dependent proteolysis and protein ubiquitination (including ERAD and autoubiquitination), along with signaling events in the NF-\u03baB and TNF pathways (I\u03baB phosphorylation, NF-\u03baB activation). This points to a coherent theme of ubiquitin-driven protein turnover coupled with inflammatory signaling. Despite zero edges, the functional signal is clear and cohesive.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0016567","count":9},{"id":"GO:0030433","count":8},{"id":"GO:1903721","count":7},{"id":"GO:0007250","count":7}]},{"hash":"53981864000811452","title":"Developmental signaling and morphogenesis cluster","description":"The top GO terms point to a range of developmental processes across tissues (heart, lung, eye, vasculature) and aspects of patterning and guidance (Wnt signaling, cell adhesion, endothelial differentiation, axon guidance). There isn't a single dominant pathway, but a shared theme of developmental signaling and morphogenesis across organ systems, so this label captures the common function of the cluster.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0003213","count":2},{"id":"GO:0060488","count":2}]},{"hash":"1572794226607130774","title":"Translation and tRNA Modification Machinery","description":"The top GO terms center on translation (cytoplasmic and mitochondrial), tRNA wobble uridine modification, and regulation of translational fidelity, suggesting a core function in protein synthesis and RNA modification. Other terms like antibiotic/biotin/menaquinone biosynthesis and basement membrane development appear as less connected annotations, likely noise or broader roles, but the strong clustering around translation-related processes supports a label focused on ribosome-associated functions and tRNA modification.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0009102","count":2},{"id":"GO:0018027","count":2},{"id":"GO:0002098","count":2},{"id":"GO:0032543","count":2}]},{"hash":"887751109581711335","title":"Retroviral DNA replication and integration","description":"This cluster is enriched for GO terms tied to reverse transcription (RNA-templated DNA synthesis), DNA replication and recombination, DNA integration, and establishment of integrated proviral latency, plus viral entry and nuclear penetration, indicating proteins involved in the retroviral lifecycle and proviral maintenance rather than general host DNA processes.","confidence":"High","size":28,"edges":130,"triangles":247,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0015074","count":9},{"id":"GO:0075713","count":9},{"id":"GO:0039651","count":8},{"id":"GO:0006278","count":8}]},{"hash":"1001286903163303351","title":"RNA cap and N-terminal protein methylation","description":"The top terms include RNA guanine-N7 methylation, 7-methylguanosine mRNA capping, and several N-terminal methylation processes, pointing to methyltransferase activities on RNA caps and protein N-termini. Lipid biosynthesis terms appear secondary to these core methylation functions.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":13},{"id":"GO:0018013","count":13},{"id":"GO:0006370","count":13},{"id":"GO:0001887","count":12},{"id":"GO:0006656","count":12}]},{"hash":"688245353427929956","title":"RNA and protein methyltransferases","description":"The top GO terms are dominated by RNA cap formation (m7G capping) and widespread N-terminal and amino-acid methylation, plus tRNA wobble modification, indicating a cluster centered on RNA- and protein-methyltransferase activities.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":16},{"id":"GO:0018013","count":15},{"id":"GO:0006370","count":15},{"id":"GO:0046690","count":13},{"id":"GO:0018012","count":13}]},{"hash":"1853320323260156599","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:0045087","count":14},{"id":"GO:0051607","count":14},{"id":"GO:0006914","count":13},{"id":"GO:0031664","count":13}]},{"hash":"1079405360075543326","title":"Planar Polarity and Adhesion in Morphogenesis","description":"The top GO terms strongly point to adhesion-related processes (hemidesmosome assembly, substrate adhesion-dependent cell spreading, homophilic cell\u2013cell adhesion) and planar polarity/morphogenesis (planar polarity establishment, lung branching morphogenesis, axon guidance). This suggests a cohesive role for these proteins in coordinating cell adhesion and polarized tissue organization during development, with PCP pathways guiding morphogenic processes. GPCR signaling appears secondary to the core adhesion/polarity theme. ","confidence":"High","size":28,"edges":363,"triangles":2926,"max_degree":27,"top_function":"wound healing","top_go_terms":[{"id":"GO:0031581","count":13},{"id":"GO:0034446","count":13},{"id":"GO:0007156","count":12},{"id":"GO:0007213","count":12},{"id":"GO:0060488","count":12}]},{"hash":"355602721422335398","title":"Angiogenesis Regulation and Endothelial Signaling","description":"The top GO terms cluster around regulation of angiogenesis, VEGF signaling, and endothelial cell behavior (e.g., negative regulation of angiogenesis, positive regulation of VEGF signaling, negative regulation of endothelial chemotaxis, cell-matrix adhesion), suggesting a cohesive theme of vascular development and endothelial regulation. While other terms (thyroid hormone generation, complement activation, synapse assembly) appear, they are less central to the dominant vascular-focused signal. Therefore, the label emphasizes the core function of the group: vascular regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":5},{"id":"GO:0006590","count":4},{"id":"GO:1900748","count":4},{"id":"GO:0032331","count":4},{"id":"GO:2001027","count":4}]},{"hash":"767752843042252737","title":"Cardiovascular and endothelial development","description":"This cluster is dominated by GO terms tied to heart morphogenesis (e.g., right atrium morphogenesis, Notch pathway in heart field) and endothelial differentiation (venous endothelial differentiation), plus regulation of angiogenesis and responses to mechanical stimuli, indicating a shared role in heart and vascular development. A single term about glomerular basement membrane development is an outlier but does not override the cardiovascular-centric theme.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032836","count":4},{"id":"GO:0003213","count":3},{"id":"GO:0060843","count":3},{"id":"GO:0003270","count":3},{"id":"GO:0071260","count":3}]},{"hash":"1665572578488711320","title":"Neural excitability and auditory signaling","description":"This cluster centers on neuronal signaling: ion transport across membranes (Ca, Na, K), membrane depolarization, excitatory postsynaptic potentials, and regulation of nerve impulse, paired with sensory-related GO terms for startle and sound perception, plus related responses (cocaine) and circadian sleep modulation. Together these point to ion-channel\u2013driven neural excitability and auditory/sensory processing.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":20},{"id":"GO:0001964","count":20},{"id":"GO:0045188","count":20},{"id":"GO:0071805","count":18},{"id":"GO:0050910","count":18}]},{"hash":"2125257572687980908","title":"Neuronal signaling and synaptic plasticity","description":"The GO terms cluster around neural transmission and synaptic regulation (vesicle fusion, receptor internalization, synaptic depression) and extend to behavior-related responses (startle, prepulse inhibition, conditioned taste aversion, ethanol response), suggesting a coherent theme of neuronal signaling and synaptic modulation that can underlie learned behaviors.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0060134","count":2},{"id":"GO:0001661","count":2},{"id":"GO:0001964","count":2},{"id":"GO:0048149","count":2}]},{"hash":"1580764651745119329","title":"Membrane Transporters and Signaling","description":"Top GO terms point to plasma membrane\u2013level transport (amino acids, calcium) and receptor/internalization, with additional signals related to integrin signaling, tight junctions, and angiogenesis. This suggests a cluster of membrane-associated proteins involved in transport and surface signaling rather than a single, cohesive pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032973","count":4},{"id":"GO:1990034","count":4},{"id":"GO:0007601","count":2},{"id":"GO:0021510","count":2},{"id":"GO:2001046","count":2}]},{"hash":"1145919062319607081","title":"Growth factor signaling and metabolic regulation","description":"This cluster centers on growth-factor signaling (EGF response, insulin signaling) and metabolic regulation (glycogen biosynthesis, fatty acid beta-oxidation), with minor ties to apoptosis and cytoskeletal control. The common theme is coordination of growth signaling with metabolic state, rather than a single precise function. The lack of edges may reflect limited interaction data rather than true functional separation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0045725","count":3},{"id":"GO:0032000","count":2},{"id":"GO:0031999","count":2},{"id":"GO:0034316","count":2}]},{"hash":"1347974959661892964","title":"TLR NF-\u03baB Innate Immune Signaling","description":"The terms cluster around innate immunity and Toll-like receptor pathways leading to NF-\u03baB activation: cellular responses to lipopolysaccharide, TLR3/9 signaling, MyD88-dependent TLR signaling, IL-1\u2013mediated signaling, and I\u03baB phosphorylation, plus lysosome localization, indicating a cohesive TLR\u2013NF-\u03baB signaling module.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0007252","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0045087","count":3}]},{"hash":"879923658555996057","title":"Pain signaling and synaptic plasticity","description":"The cluster shows strong signals for pain response and sensory perception of pain, along with regulation of synaptic plasticity by receptor localization to the synapse and involvement in the Wnt pathway, indicating a neuronal signaling module related to pain processing.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":4},{"id":"GO:0010745","count":4},{"id":"GO:0048549","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0016055","count":4}]},{"hash":"1756435390018028794","title":"Organ development and morphogenesis signaling","description":"The terms emphasize developmental processes (organ identity, lung branching morphogenesis), growth and proliferation, angiogenesis, adhesion, and GPCR signaling, all consistent with signaling networks that drive organ morphogenesis and tissue remodeling. Ubiquitin-mediated proteolysis also supports dynamic regulation during development. Therefore this label captures the cluster's common theme.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0048496","count":3},{"id":"GO:2000312","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0048146","count":2}]},{"hash":"2137695339162151085","title":"Synaptic adhesion and spine morphogenesis","description":"The top GO terms cluster around cell-matrix and cell-cell adhesion, receptor clustering, and protein localization to synapse, along with dendritic spine morphogenesis and Rho-mediated signaling. These together point to adhesion and remodeling processes at synapses, driven by cytoskeletal dynamics, aligning with neural connectivity and related behaviors (vocalization and grooming). The presence of the lectin pathway complement activation may reflect synaptic pruning/ECM interactions but does not outweigh the central neural adhesion/spine remodeling theme.","confidence":"High","size":27,"edges":16,"triangles":5,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007160","count":15},{"id":"GO:0071625","count":13},{"id":"GO:0043113","count":13},{"id":"GO:0007157","count":13},{"id":"GO:0001867","count":12}]},{"hash":"878636004709453388","title":"ECM remodeling and angiogenesis","description":"The dominant terms are collagen fibril organization, elastic fiber assembly, and heparin proteoglycan biosynthesis, pointing to extracellular matrix (ECM) organization. The presence of positive regulation of ERK1/2 cascade and angiogenesis ties ECM remodeling to vascular development, while inflammatory signals (IL-1 response, MIF signaling) fit tissue remodeling contexts. Together, these suggest a cluster focused on ECM structure with vascular and inflammatory remodeling aspects.","confidence":"High","size":27,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0034116","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0051005","count":4},{"id":"GO:0030210","count":4}]},{"hash":"1305071348795920654","title":"Lectin pathway and Fc receptor signaling","description":"This cluster is dominated by GO terms tied to innate immune signaling via lectin-mediated pathways and Fc receptor pathways (complement activation via the lectin pathway, C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, and responses to fungal components). While a couple of terms relate to development (cartilage condensation, metanephric tubule development), the strongest and most recurrent signals point to immune recognition and signaling through lectin and Fc receptors, suggesting a cohesive theme of innate immune signaling. ","confidence":"Medium","size":27,"edges":12,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0001502","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0072237","count":5},{"id":"GO:0071226","count":5}]},{"hash":"2119226806134064849","title":"DNA-Templated Transcription Regulators","description":"The cluster is dominated by GO terms for DNA-templated transcription and regulation of transcription, including Notch signaling, along with terms tied to differentiation (myoblast differentiation and vasculogenesis). This points to a group of transcription regulators involved in developmental signaling and differentiation; hydroxylation terms may reflect regulatory post-translational modifications. Overall, the theme is transcriptional control linked to differentiation processes.","confidence":"Medium","size":27,"edges":11,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0061428","count":4},{"id":"GO:0042264","count":4},{"id":"GO:0036138","count":4},{"id":"GO:0045663","count":4}]},{"hash":"1234574316507480798","title":"Actin dynamics and cardiac development signaling","description":"This cluster is dominated by terms tying actin cytoskeleton remodeling (actin filament binding, Rho signaling) with developmental signaling (Wnt pathway) and heart development, suggesting proteins coordinating cytoskeletal changes with cardiac developmental signals. Other terms like apoptosis or innate immunity are present but less central to the apparent core function.","confidence":"Medium","size":27,"edges":133,"triangles":310,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0006915","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0042997","count":6},{"id":"GO:0042220","count":6}]},{"hash":"2009204061159063289","title":"Translation machinery and translational regulation","description":"This cluster is strongly enriched for translation-related GO terms, including global translation, cytoplasmic and mitochondrial translation, ribosome disassembly, and regulatory aspects of translation. While a few other terms (glial proliferation, antibiotic response, selenocysteine incorporation, mRNA decay) appear, the dominant signal is protein synthesis and its control, making this label representative. ","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":21},{"id":"GO:0046677","count":10},{"id":"GO:0014009","count":8},{"id":"GO:0045901","count":8},{"id":"GO:0032790","count":8}]},{"hash":"1006236366444574910","title":"Thermo-sensory and circadian response cluster","description":"These proteins are linked to startle response, temperature stimulus, diet-induced thermogenesis, circadian sleep regulation, and sensory/pain perception, with support from calcium and sodium transport terms. Together, they point to a theme of organismal responses to environmental cues and metabolic state, centered on thermo-sensory signaling and circadian timing. While developmental terms appear, the dominant signal is environmental stimulus response, justifying the label. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001964","count":10},{"id":"GO:0098703","count":10},{"id":"GO:0045188","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0002024","count":10}]},{"hash":"1787726744450966890","title":"RNA processing and splicing regulation","description":"The top GO terms cluster around post-transcriptional RNA regulation: mRNA polyadenylation, stabilization, and modification, along with regulation of alternative splicing via the spliceosome, plus related processome and rRNA maturation activities. This suggests a cohesive theme of RNA processing and splicing control underlying the protein cluster, despite some obsolete annotations.","confidence":"High","size":27,"edges":66,"triangles":37,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:1900363","count":3},{"id":"GO:0001825","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0003257","count":2},{"id":"GO:0006378","count":2}]},{"hash":"109476780725357217","title":"Embryonic Development and Morphogenesis","description":"The top GO terms point to broad developmental and morphogenetic processes across tissues, including pancreatic and endocrine development, left\u2013right patterning, placental and trophoblast differentiation, cartilage morphogenesis, and spermatogenesis, with Rho GTPase signaling regulation supporting cytoskeletal changes during morphogenesis. This suggests the cluster captures a general developmental/differentiation program rather than a single pathway.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060972","count":2},{"id":"GO:0035270","count":2}]},{"hash":"2144975457014276345","title":"RNA processing and signaling regulators","description":"GO terms cluster around RNA processing regulation (splicing, mRNA export, polyadenylation, ncRNA silencing) and diverse signaling responses (retinoic acid, TGF-beta, PDGF), plus GTPase activity regulation and development terms; this suggests a set of regulatory proteins that coordinate RNA metabolism with signaling during development, rather than a single specific pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0061551","count":2},{"id":"GO:0048008","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0031047","count":2}]},{"hash":"2177438390443043509","title":"Mitochondrial fatty acid beta-oxidation","description":"Top terms cluster around mitochondrial fatty acid breakdown (long-chain fatty acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase), carnitine metabolism (carnitine biosynthetic/metabolic processes), and mitochondrial energy production (mitochondrial electron transport, NADH to ubiquinone). This suggests the proteins function primarily in beta-oxidation and energy metabolism within mitochondria. Some terms are obsolete or reflect broader metabolic stress responses (e.g., response to cold), but the dominant theme is fatty acid catabolism via the carnitine shuttle in mitochondria.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0051572","count":3},{"id":"GO:0009409","count":3},{"id":"GO:0045329","count":3},{"id":"GO:0006120","count":3}]},{"hash":"1114902235562759587","title":"Neural development and myelination","description":"The top GO terms point to Hedgehog/smoothened signaling, axonal fasciculation, myelination, synapse assembly, and cell adhesion, all core aspects of neural development and connectivity. Also, terms like innate immune response and complement activation may reflect microglial involvement in synapse remodeling during CNS development. An otolith morphogenesis term suggests broader developmental roles, but the dominant signal is neural development, synaptogenesis, and myelination.","confidence":"High","size":27,"edges":37,"triangles":0,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007224","count":9},{"id":"GO:0007413","count":9},{"id":"GO:0042552","count":8},{"id":"GO:0032474","count":8},{"id":"GO:0051965","count":8}]},{"hash":"1794209958179109133","title":"Innate Immune and Inflammatory Proteins","description":"The top GO terms are dominated by innate immune response, inflammatory response, and defense against Gram-positive bacteria, suggesting a core theme around immune signaling and host defense. Some outlier terms (mitochondrial import, complex assembly, chromatin assembly, DNA replication) indicate possible dual roles or non-immune functions in this cluster, but the strongest and most recurrent signals point to innate immunity and inflammation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0045041","count":2},{"id":"GO:0033617","count":2},{"id":"GO:0061641","count":2}]},{"hash":"134793908019448867","title":"Xenobiotic and hormone and glycan metabolism","description":"The top GO terms point to metabolism of a wide range of small molecules and hormones (xenobiotics, bile acids, thyroid hormone, catecholamines, flavonoids) and glycan-related processes (N-acetylglucosamine and glycosaminoglycan biosynthesis/modification). This suggests a coherent cluster of metabolic enzymes involved in processing diverse compounds and glycans, rather than a single pathway.","confidence":"Medium","size":27,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030573","count":7},{"id":"GO:0006044","count":7},{"id":"GO:0015015","count":7},{"id":"GO:0042403","count":7},{"id":"GO:0030205","count":7}]},{"hash":"1828949203001390833","title":"Rho-ERK Signaling in Immune and Neural Development","description":"The cluster shows enrichment for Rho GTPase regulation, ERK/MAPK signaling, PI3K activity, T cell receptor signaling, innate immunity, GM-CSF response, and nervous system development with neuron apoptosis regulation, suggesting a coherent module of cytoskeletal and MAPK signaling coordinating immune and neural development processes.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0050852","count":4}]},{"hash":"667300999513118703","title":"Neural development and sensory perception proteins","description":"These terms cluster around nervous system development and sensory-related processes (e.g., detection of mechanical stimuli in pain, oligodendrocyte differentiation, and general nervous system development), with additional signals of protein regulation (ubiquitination) and vitamin D response that may modulate neural contexts. The mix is plausible for a neural/sensory function cluster, though some term noise (immune-related, heat response) reduces certainty.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":7},{"id":"GO:0050966","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0035914","count":5},{"id":"GO:0016567","count":5}]},{"hash":"1022424558035021059","title":"Developmental morphogenesis and ECM biosynthesis","description":"This cluster shows a clear bias toward tissue development and shaping, with terms like bone development, cornea development, and retinal ganglion cell axon guidance, plus collagen biosynthesis indicating extracellular matrix formation. The presence of branching morphogenesis of nerves and multicellular organism development reinforces a unifying theme of morphogenesis and ECM remodeling, despite a few ancillary terms related to transcription regulation or autophagy-like processes.","confidence":"High","size":27,"edges":40,"triangles":0,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0046513","count":3},{"id":"GO:0032964","count":3},{"id":"GO:0060348","count":2},{"id":"GO:0032258","count":2},{"id":"GO:0006355","count":2}]},{"hash":"817620532549538166","title":"BMP Signaling Regulation and Developmental Morphogenesis","description":"This cluster is enriched for BMP pathway regulation (both positive and negative) along with genes involved in collagen fibril organization and development-related processes such as EMT in heart formation, endothelial activation, myelination, and seminiferous tubule development, suggesting a coherent theme of developmental signaling and morphogenesis centered on BMP control.","confidence":"High","size":27,"edges":42,"triangles":0,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050731","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0030514","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0030513","count":3}]},{"hash":"858319218323173229","title":"Gene Expression and Growth Signaling Regulators","description":"The top GO terms point to regulation of transcription and DNA binding (DNA-templated transcription, positive regulation of DNA binding), and several terms indicate modulation of signaling pathways and growth-related processes (growth hormone response, protein kinase activity, cell proliferation, mitotic cell cycle). While there are some broader or tangential terms (pigmentation, calcium-regulated cardiac contraction), the dominant theme is regulatory proteins that control gene expression and cellular signaling involved in growth and proliferation. Confidence: Medium.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0060416","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0043388","count":2}]},{"hash":"1753645573087145813","title":"Neural crest migration and axon guidance","description":"The top GO terms fall squarely into neural development, highlighting neural crest\u2013driven migration (ventral trunk neural crest), sympathetic neuron projection and guidance, trigeminal nerve organization, branchiomotor neuron axon guidance, and axonal fasciculation, all reinforced by semaphorin-plexin signaling. Paranode protein localization and VEGF/VEGFR signaling are present but fit within the broader neuronal wiring/vascular development context. Taken together, these terms point to coordinated neural crest\u2013derived cell movement and axon pathfinding during development.","confidence":"High","size":27,"edges":127,"triangles":270,"max_degree":19,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0036486","count":8},{"id":"GO:0097490","count":8},{"id":"GO:0097491","count":8},{"id":"GO:1902287","count":8},{"id":"GO:0021637","count":8}]},{"hash":"2190297669305936230","title":"Embryonic craniofacial and sensory organ morphogenesis","description":"The top terms cluster around craniofacial and skeletal development (roof of mouth, viscerocranium, osteoblasts), early embryogenesis (primitive streak), and sensory organ formation (retina, cochlea), with transcription regulation, indicating a coherent developmental program for facial skeleton and sensory structures in embryos.","confidence":"High","size":27,"edges":207,"triangles":561,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":15},{"id":"GO:0090009","count":15},{"id":"GO:0048703","count":14},{"id":"GO:0002076","count":12},{"id":"GO:0002087","count":12}]},{"hash":"1287223169217627800","title":"Developmental Gene Expression and RNA Processing","description":"The top GO terms center on DNA-templated transcription, mRNA splicing, and rRNA maturation, with developmental signals (multicellular organism development, spinal cord development) and cell-cycle-related terms, suggesting a theme of gene expression regulation and RNA processing embedded in development, rather than a single, cohesive pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1466751121559241652","title":"ECM-Driven Vascular Remodeling","description":"The top terms cluster around collagen fibril organization, regulation of angiogenesis and vasoconstriction, and blood coagulation, plus proteoglycan biosynthesis and cell adhesion, which together point to extracellular matrix components shaping vascular remodeling and coagulation processes. Some terms (UV protection and DNA damage checkpoint signaling) are less connected to this theme, but the dominant signals reflect ECM-vascular biology. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030199","count":5},{"id":"GO:0016525","count":5},{"id":"GO:0045907","count":5},{"id":"GO:0072378","count":5},{"id":"GO:0031573","count":5}]},{"hash":"985532701751544190","title":"Auditory-vestibular neural signaling and behavior","description":"Top GO terms cluster around neural signaling in auditory-vestibular pathways, including calcium import, acetylcholine and GABA receptor activity, and development, along with behavior and circadian regulation (startle, walking, sleep cycles). This combination suggests a cohesive module focused on sensory processing in the auditory-vestibular system and its behavioral outputs.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0098703","count":23},{"id":"GO:0001964","count":23},{"id":"GO:0045188","count":23},{"id":"GO:0007605","count":22},{"id":"GO:0051970","count":21}]},{"hash":"617226663167991912","title":"Adenylate cyclase-activating GPCR signaling","description":"This cluster centers on GPCR signaling that activates adenylate cyclase (GO:0010579, GO:0007190), suggesting a core cAMP-mediated signaling theme. The inclusion of vasopressin-related blood pressure regulation and photoreceptor maintenance supports GPCR/cAMP roles in vascular and sensory tissues. Additional terms about temperature response, IL-1\u03b2 production, dendritic cell differentiation, and cell proliferation reflect downstream, systemic roles of GPCR signaling in immune regulation and development. The electron transport chain term provides metabolic context but does not override the central GPCR-cAMP signaling pattern.","confidence":"High","size":27,"edges":325,"triangles":2350,"max_degree":26,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0007190","count":26},{"id":"GO:0045494","count":25}]},{"hash":"1391153325552224438","title":"Multisystem Development and Differentiation","description":"The top GO terms span development across multiple tissues (nervous system, spermatid, keratinization, ossification) suggesting a broad role in tissue differentiation. Additional terms point to signaling (JNK cascade) and cell proliferation (mitotic cell cycle), while transport and autophagy-related terms (Golgi to plasma membrane transport, cytoplasm to vacuole targeting) reflect general cellular processes underpinning growth. Together, these indicate a broad developmental/differentiation function across organ systems.","confidence":"Medium","size":27,"edges":39,"triangles":6,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0007286","count":8},{"id":"GO:0032707","count":8},{"id":"GO:0006893","count":8}]},{"hash":"1247832208221058011","title":"Innate Immune Response and Cytokine Production","description":"The cluster is dominated by terms for innate immunity and inflammatory signaling: innate immune response, inflammatory response, cytokine and chemokine production (including IL-12 and IL-17 pathways), and defense against Gram-positive bacteria. This pattern indicates a cohesive module of innate immune activation and cytokine-mediated communication.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090197","count":12},{"id":"GO:0006954","count":11},{"id":"GO:0051092","count":11},{"id":"GO:0050830","count":11},{"id":"GO:0002374","count":10}]},{"hash":"1023193996973440080","title":"Unknown","description":"The top GO terms span translation initiation and preinitiation complex formation, regulation of translation, along with apparently unrelated processes like apoptotic cell recognition, neural signaling, and development. With no clear cohesive biological function or pathway linking these terms and with edges/degree being zero, there isn\u2019t a single, representative theme for this cluster. Therefore, a generic Unknown label is most appropriate.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043654","count":2},{"id":"GO:0051971","count":2},{"id":"GO:0075525","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0006446","count":1}]},{"hash":"1349702344777315304","title":"Axon guidance and neural crest migration","description":"The top GO terms cluster around neuron pathfinding: axonal fasciculation; neural crest cell migration; sympathetic neuron projection extension and guidance; semaphorin-plexin signaling in axon guidance; trigeminal nerve organization; branchiomotor neuron axon guidance; and axon extension in guidance. This suggests the proteins act together in axon pathfinding and neural crest\u2013related migration during development. A single outlier term (coronary artery morphogenesis) likely reflects shared signaling pathways rather than a secondary function. Overall, the theme is neural development focused on axon guidance and neural crest migration.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":9},{"id":"GO:0036486","count":9},{"id":"GO:0097490","count":9},{"id":"GO:0097491","count":9},{"id":"GO:1902287","count":9}]},{"hash":"21224176175522370","title":"Broad-spectrum membrane transporters","description":"The top GO terms show transmembrane transport for nitrite, nitrate, xenobiotics, sialic acid, vitamins, and sodium, plus a token for neurotransmitter loading into vesicles, all pointing to a cohesive function as diverse membrane transport proteins moving multiple substrates rather than a single substrate. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":3},{"id":"GO:0006855","count":3},{"id":"GO:1900754","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0042128","count":3}]},{"hash":"1050578630958650614","title":"Cholinergic neuromuscular signaling and auditory perception","description":"The top GO terms cluster around acetylcholine receptor signaling, cholinergic synaptic transmission, and nerve impulse transmission, with links to sound perception and mechanical stimulus detection, plus nicotine/insecticide response and muscle-related growth/behavior. This suggests a cohesive module of cholinergic signaling at neuromuscular and auditory/sensory pathways, including related behavioral outputs.","confidence":"High","size":27,"edges":78,"triangles":123,"max_degree":11,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0050910","count":20},{"id":"GO:0048630","count":18},{"id":"GO:0007605","count":18},{"id":"GO:0095500","count":17},{"id":"GO:0007628","count":17}]},{"hash":"669206425934259816","title":"Developmental morphogenesis and ECM remodeling","description":"Based on GO terms like collagen fibril organization, connective tissue and heart development, nipple morphogenesis, and axon guidance, the cluster seems focused on tissue morphogenesis and extracellular matrix remodeling, with supporting neural development signals and some inflammatory context.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006469","count":7},{"id":"GO:0007409","count":6},{"id":"GO:0030199","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0060658","count":5}]},{"hash":"112904012816593327","title":"Neurodevelopment and Innate Immunity","description":"The top GO terms point to neural development (neuron projection development, axonal fasciculation, synapse assembly, cell adhesion) and lens fiber differentiation, suggesting developmental processes in nervous/system tissues; the presence of innate immune response and complement activation indicates accompanying immune signaling. Overall, the cluster seems to group proteins involved in neural/ocular development with innate immune-related functions, rather than a single, cohesive pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0051965","count":4}]},{"hash":"420244612638730064","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":5},{"id":"GO:0006541","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006808","count":2},{"id":"GO:0001680","count":2}]},{"hash":"2202523585080012362","title":"Olfactory bulb interneuron migration and neuroinflammation","description":"The cluster prominently features terms about tangential migration of olfactory bulb interneurons, chemorepulsion guiding postnatal OB interneuron migration, and synapse assembly, alongside inflammatory and cortisol response terms and Notch signaling regulation. This combination points to a coherent module governing OB interneuron development and migration in a neuroinflammatory/stress context, rather than a generic immune or metabolic program. Confidence: High","confidence":"","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":13},{"id":"GO:0006954","count":13},{"id":"GO:0045746","count":13},{"id":"GO:0022028","count":12},{"id":"GO:0050929","count":12}]},{"hash":"1991931683578926091","title":"Developmental signaling and tissue patterning","description":"The top GO terms point to development and patterning across tissues (Notch signaling regulation, segmentation, epithelial and ovarian development, compartment patterning) with supporting glycosylation processes that can modulate signaling; despite one plant-like term (cell wall organization), the overarching theme is developmental signaling and tissue organization.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0032092","count":6},{"id":"GO:0071555","count":5},{"id":"GO:0016266","count":5},{"id":"GO:0036011","count":5},{"id":"GO:0002315","count":5}]},{"hash":"434269794245336516","title":"Innate antiviral interferon response and ER stress","description":"The top GO terms show a strong enrichment for innate immune processes (innate immune response, cellular response to type I interferon, dsRNA response, antiviral defense regulation) together with endoplasmic reticulum (ER) stress and unfolded protein response\u2013related processes (translation initiation during ER stress, response to unfolded protein). This points to a cluster of proteins involved in antiviral innate immunity and ER stress signaling, with some peripheral links to cell cycle and signaling regulation. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0071357","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0050689","count":7},{"id":"GO:0071360","count":7}]},{"hash":"1270995401882049682","title":"Visual system development and photoreceptor function","description":"The cluster is dominated by vision-related GO terms: visual perception and photoreceptor cell maintenance, with melanosome transport supporting pigment-related functions in ocular tissues and vesicle docking in exocytosis reflecting synaptic secretion in retinal neurons. While several terms are broader (growth regulation, general neural development, platelet signaling), the strongest common theme centers on eye/visual system biology, suggesting a role in photoreceptor maintenance and visual signaling.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006904","count":3},{"id":"GO:0045494","count":2},{"id":"GO:0040015","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0048745","count":2}]},{"hash":"851826366453947229","title":"Mitochondrial energy metabolism and mitophagy","description":"The cluster shows strong ties to mitochondrial function, with terms like autophagy of mitochondrion, regulation of cellular respiration, and proton transmembrane transport pointing to energy production and mitochondrial quality control. Additional terms related to protein homeostasis (protein oligomerization, proteolysis) support this theme, while some terms (e.g., viral process, PQQ biosynthesis) may reflect annotation artefacts or broader associations. Overall, mitochondria-centered processes best unify the set.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010259","count":2},{"id":"GO:0000422","count":2},{"id":"GO:0043457","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0018189","count":2}]},{"hash":"1626662104704401190","title":"TNF/NF-kappaB inflammatory and necroptotic signaling","description":"Top terms converge on NF-kappaB signaling, TNF production, necroptosis, and extrinsic apoptosis, with immune response annotations; together they suggest a TNF-driven inflammatory and cell-death regulation module.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":6},{"id":"GO:0043123","count":6},{"id":"GO:0097527","count":5},{"id":"GO:0032760","count":5},{"id":"GO:0097202","count":5}]},{"hash":"1296146384466681404","title":"Developmental morphogenesis and signaling","description":"The top GO terms point to broad developmental and tissue morphogenesis processes (multicellular organism development, sarcomere organization, roof of mouth and lung mesenchyme development), along with signaling related to TGF-beta, FGF, and cytokine production. This suggests a general theme of developmental patterning and tissue formation rather than a single specific function, making a developmental/morphogenetic label most representative.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048843","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0060021","count":2},{"id":"GO:2000347","count":2}]},{"hash":"1769733048331856727","title":"Embryonic development and organ morphogenesis","description":"This cluster shows broad developmental and morphogenetic processes across multiple tissues, including trophoblast differentiation, left-right patterning, pancreatic/endocrine development, cartilage morphogenesis, and EMT in heart formation. A few terms related to neuronal function and ion transport may reflect tissue-specific differentiation within developing systems, but the common theme is embryonic tissue development and organogenesis.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0035270","count":2}]},{"hash":"1218576429045874280","title":"Unknown","description":"The top GO terms span sensory detection, synaptic regulation, cell cycle processes, telomere maintenance, adipogenesis, cardiac development, and hormone signaling, with no clear, shared function tying the cluster together. This diversity suggests there isn\u2019t a single coherent biological theme for the entire protein set. Therefore, a specific, representative label cannot be confidently assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0007253","count":2},{"id":"GO:0032212","count":2}]},{"hash":"294465426097322234","title":"Axon Guidance and Synapse Development","description":"Several top GO terms indicate neural wiring and connectivity, including commissural neuron axon guidance, semaphorin-plexin signaling in axon guidance, sympathetic neuron development and projection, trigeminal nerve organization, and maintenance or assembly of synapses. These together point to processes shaping neural circuits and synaptic connectivity. The presence of complement activation may reflect roles in synaptic pruning, but the dominant theme across terms is neural development and synaptic guidance/maintenance.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0051965","count":5},{"id":"GO:0045880","count":4},{"id":"GO:0071679","count":4},{"id":"GO:0061549","count":4}]},{"hash":"405994841090523732","title":"Wnt-Calcium Developmental Signaling","description":"This cluster is enriched for embryonic development processes (cartilage condensation, neuromast hair cell differentiation, metanephric proximal tubule development, lymph vessel morphogenesis) and includes components of the calcium-modulating branch of Wnt signaling, along with regulators of calcium release and hypoxia responses. It also features cytokine regulation (IL-6/IL-10), suggesting a coordinated interplay between development, calcium signaling, and immune modulation. The unifying theme is Wnt-Ca2+ signaling governing tissue morphogenesis.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":6},{"id":"GO:0007223","count":4},{"id":"GO:0032715","count":4},{"id":"GO:0048903","count":4},{"id":"GO:0032733","count":4}]},{"hash":"1830832256861589206","title":"Ubiquitin-Dependent T Cell Regulation","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic processes, with strong signals for T cell homeostasis and T-helper differentiation, plus regulation of apoptosis, necroptosis, transcription, histone turnover, and actin ubiquitination. This points to a coherent theme of ubiquitin-mediated signaling controlling T cell fate, survival, and cell-cycle processes, with broader chromatin and cytoskeletal regulation. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0033280","count":11},{"id":"GO:0043029","count":10},{"id":"GO:0071157","count":9},{"id":"GO:0000122","count":9}]},{"hash":"364217763670051404","title":"Unknown","description":"The top GO terms span vascular processes (angiogenesis, blood coagulation), endocytosis and mechanical signaling, lipid metabolism, neural differentiation, glucose transport, and reproductive cycling, with no clear single theme tying them together. Several terms are obsolete or weakly connected, so no coherent function label can be assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090305","count":4},{"id":"GO:0045765","count":4},{"id":"GO:0030194","count":4},{"id":"GO:0006898","count":4},{"id":"GO:0071260","count":4}]},{"hash":"58834622154734560","title":"Neural crest migration and axon guidance","description":"The cluster is dominated by neural development terms: ventral trunk neural crest cell migration, commissural neuron axon guidance, sensory neuron axon guidance, retinal ganglion cell axon guidance, and synapse maturation, all pointing to nervous system wiring. Activation of receptor tyrosine kinases aligns with signaling needed for such development. Some outliers (complement activation, cuticle molting) are less connected to this core theme.","confidence":"High","size":26,"edges":111,"triangles":187,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0007171","count":21},{"id":"GO:0001867","count":21},{"id":"GO:0036486","count":17},{"id":"GO:0071679","count":17},{"id":"GO:0060074","count":17}]},{"hash":"2187001741487299480","title":"Embryonic kidney and vascular development with immune cues","description":"The top terms show kidney development (metanephric ascending limb, mesonephric duct), vascular/lymphatic morphogenesis (lymph vessel morphogenesis, cell-matrix adhesion), and several innate immune processes (complement activation lectin pathway, leukocyte tethering/rolling, phagocytosis recognition), suggesting a cluster centered on embryonic organogenesis with immune-adhesion signaling.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0001867","count":22},{"id":"GO:0072218","count":17},{"id":"GO:0050901","count":16},{"id":"GO:0010572","count":16},{"id":"GO:0007160","count":15}]},{"hash":"1043967899898176013","title":"Immune activation and leukocyte interactions","description":"The top GO terms are dominated by immune-related processes: complement activation via the lectin pathway, phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and cellular responses to fungal molecules, suggesting the cluster centers on immune activation and leukocyte function. Some developmental terms (mesonephric/metanephric development, lymph vessel morphogenesis) are present, which may reflect tissue-specific expression overlap or multifunctionality, but the strongest signal remains immune-related.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0072177","count":4},{"id":"GO:0006910","count":4},{"id":"GO:0072218","count":4},{"id":"GO:0050901","count":4}]},{"hash":"1999920125593490126","title":"Glycan biosynthesis and glycoprotein processing","description":"The cluster\u2019s top GO terms consistently point to glycosylation and glycan remodeling, including N-linked glycosylation via asparagine, N-glycan processing, protein sialylation, oligosaccharide metabolism, and ganglioside biosynthesis. Some terms about pollen and olfactory development seem outliers, likely annotation noise, but the shared theme is glycan assembly and modification in the secretory pathway.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009860","count":5},{"id":"GO:0009311","count":5},{"id":"GO:0018279","count":5},{"id":"GO:0001574","count":5},{"id":"GO:0021628","count":5}]},{"hash":"1410200851887884788","title":"Endothelial angiogenesis signaling and vascular remodeling","description":"The cluster shows a clear vascular theme: multiple terms relate to angiogenesis, endothelial cell migration, and regulation of blood vessel formation, including positive regulation of angiogenesis, endothelial cell migration, ERK signaling, and vasoconstriction; plus cell-matrix adhesion and platelet aggregation regulation. While a neural term appears (excitatory postsynaptic potential), the majority support a cohesive role in endothelial function and vascular remodeling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1902042","count":5},{"id":"GO:2000352","count":5},{"id":"GO:0007160","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0090331","count":4}]},{"hash":"375036372568634561","title":"Developmental transcription and tissue morphogenesis","description":"This cluster shows a mix of transcription-related terms (DNA-templated transcription, RNA polymerase II transcription) alongside developmental and morphogenesis processes (spinal cord motor neuron fate specification, cartilage condensation, collagen fibril organization, lymphangiogenesis) and related signaling. The convergence suggests proteins involved in regulating gene expression during development and shaping tissues, rather than a single isolated function.","confidence":"Medium","size":26,"edges":38,"triangles":20,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0021520","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0051301","count":2},{"id":"GO:2000324","count":2}]},{"hash":"1935029778618272575","title":"Neuronal development and myelination","description":"The cluster is enriched for nervous system development terms (substantia nigra development, nervous system development, dendritic spine development) and CNS myelin maintenance, suggesting proteins work together in neural differentiation and myelination. Small GTPase-mediated signaling supports neuronal cytoskeletal dynamics, while lipid metabolism terms may relate to membrane and myelin composition.","confidence":"High","size":26,"edges":9,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":7},{"id":"GO:0021762","count":6},{"id":"GO:0032286","count":6},{"id":"GO:0001949","count":6},{"id":"GO:0006675","count":6}]},{"hash":"171569867757304010","title":"Lipid remodeling and mitochondrial metabolism","description":"The GO terms show strong enrichment for lipid remodeling and biosynthesis, including ether lipid biosynthesis, cardiolipin remodeling, phosphatidylcholine remodeling, and CDP-diacylglycerol biosynthesis, together with mitochondrial ATP synthesis and electron transport, suggesting a shared role in membrane lipid homeostasis and energy production. While terms related to immune signaling (IL-2 production, T cell death regulation) and development (cerebellum morphogenesis, glandular epithelial maturation) are present, they appear less central to the core theme. Thus, the dominant signal points to lipid remodeling linked to mitochondrial metabolism.","confidence":"Medium","size":26,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070970","count":6},{"id":"GO:0008611","count":6},{"id":"GO:0070236","count":6},{"id":"GO:0002071","count":6},{"id":"GO:0035965","count":6}]},{"hash":"2225474956560753770","title":"Skin development and thermoregulatory signaling","description":"The cluster shows GO terms tied to skin development, temperature response, thermogenesis, pain perception, and ion transport/signaling (cAMP/cGMP, membrane potential), suggesting proteins involved in skin biology and the sensory/thermoregulatory signaling networks that integrate thermal cues with ion flux and cellular signaling. The combination of developmental and thermoregulatory/sensory terms supports a cohesive theme around skin development plus temperature- and pain-related signaling.","confidence":"Medium","size":26,"edges":188,"triangles":573,"max_degree":24,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0071502","count":11},{"id":"GO:0002024","count":11},{"id":"GO:0043588","count":10},{"id":"GO:0098719","count":8}]},{"hash":"1935792122613272433","title":"RNA processing and translation initiation regulation","description":"This cluster centers on RNA-level regulation, with frequent terms for regulatory ncRNA-mediated gene silencing, splicing regulation, and initiation control of translation (including preinitiation complex formation and reinitiation), plus IRES-dependent viral translation. The mix of splicing/polyadenylation-related terms with translation initiation/reinitiation points to a coherent theme of post-transcriptional RNA processing and control of translation initiation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":11},{"id":"GO:0048025","count":11},{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0075525","count":10}]},{"hash":"181232808956658174","title":"Glucocorticoid-responsive transcription and RNA processing regulation","description":"This cluster combines GO terms for transcriptional control (negative regulation of RNA polymerase II transcription, DNA-templated transcription) with post-transcriptional RNA metabolism (mRNA processing body assembly, poly(A) tail shortening) and ubiquitin-dependent protein turnover, plus a dexamethasone stimulus response. The overall pattern points to coordinated regulation of gene expression at both transcriptional and RNA-processing levels, with some association to glucocorticoid signaling; one term (social behavior) appears as an outlier. ","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071549","count":2},{"id":"GO:0045947","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006351","count":2}]},{"hash":"433019031401093564","title":"Chromatin-regulated immune signaling and necroptosis","description":"These proteins show enrichment for immune regulation (T-helper cell differentiation, T cell homeostasis), necroptosis modulation (regulation and negative regulation), and nuclear/chromatin processes (PML body organization, histone catabolic process, histone acetylation). The co-occurrence of immune signaling with chromatin dynamics and cell death regulation suggests a theme where chromatin state influences immune responses and necroptotic pathways.","confidence":"Medium","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045623","count":2},{"id":"GO:0045869","count":2},{"id":"GO:0036205","count":2},{"id":"GO:0030578","count":2},{"id":"GO:0043029","count":2}]},{"hash":"1827074343578168111","title":"RNA Splicing and Translation Control","description":"This cluster is dominated by GO terms on mRNA processing, notably mRNA splicing via the spliceosome, regulation of splicing, translation initiation/reinitiation, and mRNA stability under stress, pointing to a cohesive theme of RNA processing and translational regulation. A few terms (like Golgi-to-ER transport) may reflect broader cellular context but do not override the primary RNA-centric signal.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":6},{"id":"GO:0045292","count":5},{"id":"GO:0031047","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4}]},{"hash":"691986201489891304","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0010587","count":2}]},{"hash":"2047222095520083277","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0000398","count":2}]},{"hash":"747160793757091942","title":"Mitochondrial respiration and ATP synthesis","description":"This cluster is centered on mitochondrial energy production, highlighted by proton motive force-driven ATP synthesis and mitochondrial electron transport (NADH to ubiquinone). The presence of cofactor biosynthesis terms (heme via protoporphyrinogen IX, thiamine) and translation supports a broadly active metabolic module tied to energy generation, with a few unrelated terms likely incidental. ","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0015986","count":3},{"id":"GO:0099132","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0045329","count":2}]},{"hash":"668951232654546028","title":"Ribosome Biogenesis and Cell Cycle","description":"The top GO terms are dominated by ribosome biogenesis (small and large subunits), nuclear export, and tRNA modification, with accompanying DNA-templated transcription and cell division/cell cycle terms. This pattern suggests a cohesive cluster of proteins involved in ribosome assembly and related gene-expression processes that coordinate with cell cycle progression, making the ribosome-biogenesis\u2013cell-cycle axis a concise, representative theme. ","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000747","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":7},{"id":"GO:0006351","count":5}]},{"hash":"712288137458414892","title":"Embryonic Patterning and Organogenesis","description":"The GO terms point to early development and tissue specification across multiple lineages (left/right patterning, pancreatic and endocrine system development, placental and trophoblast differentiation, cartilage morphogenesis, and EMT in heart development). While a couple of terms are broad cellular processes (spindle assembly, ubiquitination), the dominant theme is embryogenesis and organogenesis, suggesting cohesive functional grouping around developmental differentiation. ","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":11},{"id":"GO:0003323","count":11},{"id":"GO:0035270","count":11},{"id":"GO:0003198","count":11},{"id":"GO:0060707","count":11}]},{"hash":"859872676410095813","title":"Glycinergic neurotransmission and amino acid transport","description":"The top terms cluster around glycine-mediated synaptic transmission and glycine transport, with related neurotransmitter handling (serotonin uptake, dopamine catabolic process) and various amino acid transport terms, suggesting a cohesive role in neural signaling and amino acid movement across membranes. While some brain development terms appear, the strongest signal is glycinergic signaling and amino acid transport in nervous tissue.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0021794","count":9},{"id":"GO:0042420","count":9},{"id":"GO:0036233","count":8},{"id":"GO:0060012","count":8},{"id":"GO:0015824","count":8}]},{"hash":"871746730075533367","title":"Lipid and metabolite biosynthesis cluster","description":"Most of the top GO terms point to biosynthetic processes for lipids and related metabolites (very long-chain fatty acid biosynthesis, fatty acid elongation, sphingolipid biosynthesis) and other metabolite pathways (retinoic acid, phylloquinone, tropane alkaloid biosynthesis). There are a few outliers (lung development, transcription regulation, drug response) that seem less directly connected, but the dominant theme is diverse biosynthesis of lipids and small molecules. ","confidence":"Medium","size":26,"edges":275,"triangles":1580,"max_degree":24,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":17},{"id":"GO:0030324","count":13},{"id":"GO:0006355","count":13},{"id":"GO:0009710","count":13},{"id":"GO:0042761","count":13}]},{"hash":"1364325211074061934","title":"Craniofacial and neural crest embryogenesis","description":"The cluster is characterized by GO terms tied to embryonic development of head structures and neural crest\u2013driven morphogenesis: cranial skeleton morphogenesis, palate (roof of mouth) development, eye development, trigeminal ganglion development, neural crest cell migration, pituitary development, and primitive streak formation, plus general transcriptional regulation during development. This combination points to proteins coordinating early craniofacial/neural crest\u2013related development processes.","confidence":"High","size":26,"edges":5,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0021983","count":9},{"id":"GO:0090009","count":8},{"id":"GO:0006355","count":7},{"id":"GO:0048701","count":7}]},{"hash":"1345056564431838909","title":"Membrane Transport and Metabolic Pathways","description":"The top GO terms point to transmembrane transport of sugars and ions (glucose, galactose, phosphate, organic cations) alongside various metabolic processes (zinc homeostasis, arginine biosynthesis, fucose metabolism) and related stress responses, suggesting a protein cluster centered on membrane transport linked to metabolism.","confidence":"Medium","size":26,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006882","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0006526","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0042149","count":2}]},{"hash":"218622625171857632","title":"Cardiac development and mechanotransduction","description":"The cluster shows enrichment for heart development (GO:0007507) and mechanosensitive responses (GO:0071260, GO:0035994), as well as calcium signaling (GO:0051209), which together point to a module involved in cardiac development and the cardiomyocyte response to mechanical stimuli. While other terms (mRNA processing, telomere maintenance, kinase regulation) are present, they don\u2019t overshadow the strongest theme of cardiac/mechanical signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006397","count":4},{"id":"GO:0051209","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0032212","count":3}]},{"hash":"2153864094435805787","title":"Integrin-mediated adhesion and immune signaling","description":"This cluster is enriched for GO terms spanning integrin signaling, cell\u2013ECM adhesion, hyaluronan metabolism, and extracellular matrix remodeling, along with innate immune responses, T cell activation, and coagulation. The common theme appears to be ECM interactions and adhesion coupled with immune signaling and inflammatory processes, suggesting roles in extracellular matrix\u2013mediated cell adhesion/remodeling and immune communication.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007229","count":6},{"id":"GO:1905050","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0030212","count":6},{"id":"GO:0045087","count":5}]},{"hash":"671980858665747744","title":"Neuronal signaling and circadian behavior","description":"The cluster\u2019s top GO terms center on synaptic transmission (excitatory postsynaptic potential, GABA and acetylcholine signaling), ion transport (sodium and calcium), and a suite of neural-behavioral phenotypes (startle response, conditioned taste aversion, adult walking) plus circadian sleep/wake regulation. This combination points to a coherent role in neural signaling and behavior modulation with circadian aspects.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":17},{"id":"GO:0001964","count":15},{"id":"GO:0098703","count":15},{"id":"GO:0045188","count":15},{"id":"GO:0001661","count":14}]},{"hash":"681958165956897651","title":"Neural development and synaptic signaling","description":"The prevailing GO terms point to neural development and synaptic activity: positive regulation of synapse assembly, neurotransmitter secretion, memory, left/right axis specification, and regulation of neural retina development, plus Notch signaling modulation. While a couple terms (blood coagulation, ATP response) are less central, the dominant themes tie to neural differentiation, synapse formation, and synaptic signaling, suggesting a cluster of proteins involved in neural development and communication.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":15},{"id":"GO:0051965","count":10},{"id":"GO:2001027","count":10},{"id":"GO:0045746","count":10},{"id":"GO:0007269","count":9}]},{"hash":"385973146713521280","title":"Cardiovascular morphogenesis and cell adhesion","description":"The top terms show a strong emphasis on heart-related development (right atrium morphogenesis, cardiac septum morphogenesis, vascular smooth muscle cell development) and tissue organization (foregut morphogenesis, heterophilic and cell-matrix adhesion). This suggests the proteins cluster around cardiovascular morphogenesis and adhesion processes that shape heart and associated tissues. Some immune-related terms appear but do not define the main theme.","confidence":"High","size":26,"edges":6,"triangles":0,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007157","count":26},{"id":"GO:0007160","count":25},{"id":"GO:0007440","count":23},{"id":"GO:0042691","count":23},{"id":"GO:0003213","count":23}]},{"hash":"364846614967365079","title":"Synaptic Vesicle Trafficking and Neural Signaling","description":"The top GO terms cluster around synaptic vesicle exo- and endocytosis regulation, excitatory postsynaptic potentials, and nervous system development, including substantia nigra development. This points to proteins involved in the cycling of synaptic vesicles and neuron-specific signaling pathways (PI-mediated signaling, GTPase activity, ERK cascade, Wnt signaling) that shape synaptic transmission and brain development. The inclusion of terms like mitotic cell cycle may be non-central noise, but the dominant theme is vesicle trafficking at synapses and neuronal signaling, especially in brain regions like the substantia nigra.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000300","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0048015","count":5},{"id":"GO:1900242","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1027119574289579632","title":"Developmental ECM remodeling and angiogenesis regulation","description":"The proteins cluster around extracellular matrix organization (collagen fibril organization), regulation of angiogenesis, and development-related signaling (brain development, Hedgehog/Smoothened pathway), with supporting terms on cell adhesion and smooth muscle growth. This suggests a cohesive theme of developmental remodeling of the extracellular matrix and vascular/neuronal development rather than a single isolated function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043154","count":4},{"id":"GO:0007584","count":3},{"id":"GO:0045880","count":3},{"id":"GO:0071375","count":3},{"id":"GO:0034116","count":3}]},{"hash":"651805579740821868","title":"Axon Guidance and Paranodal Assembly","description":"The cluster\u2019s terms are dominated by neural development and axon guidance processes, including semaphorin-plexin signaling, projection guidance of sympathetic and branchiomotor neurons, and paranodal junction assembly/localization, indicating proteins associated with axon pathfinding and paranode organization. Innate immune response appears less central to the cluster\u2019s core function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0036486","count":6},{"id":"GO:0071205","count":6},{"id":"GO:0002175","count":6},{"id":"GO:0097490","count":6}]},{"hash":"1967405897037338153","title":"Cofactor and Lipid Biosynthesis","description":"The top GO terms point to biosynthetic pathways for cofactors and lipid-derived molecules (cobalamin, ubiquinone, sterols, phosphatidylcholine, juvenile hormone), indicating a core theme of lipid/cofactor production. A few methylation-related terms appear, but the dominant signal is metabolic synthesis of lipids and cofactors, with some RNA/protein methylation annotations likely representing broader metabolic regulation. ","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":4},{"id":"GO:0001887","count":3},{"id":"GO:0006656","count":3},{"id":"GO:0006744","count":3},{"id":"GO:0031167","count":3}]},{"hash":"965143072127251214","title":"Ubiquitin-regulated skeletal muscle development","description":"The cluster is dominated by GO terms for ubiquitin-dependent proteolysis and specific ubiquitination (including K33-linked ubiquitination) alongside negative regulation of ubiquitination, and it also features sarcomere organization, skeletal muscle cell differentiation, and skeletal muscle tissue development. This points to a cohesive theme: ubiquitin signaling controlling skeletal muscle development and maturation. Some related tissue terms (distal tubule morphogenesis, renal sodium ion absorption) are present but appear secondary to the dominant muscle- and ubiquitin-associated functions. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":26},{"id":"GO:0045214","count":18},{"id":"GO:0072156","count":18},{"id":"GO:0007399","count":18},{"id":"GO:0035914","count":18}]},{"hash":"2296932909677491353","title":"Skeletal muscle development and sarcomere organization","description":"The top GO terms are dominated by skeletal muscle-related processes, including skeletal muscle tissue development, skeletal muscle cell differentiation, and sarcomere organization, indicating the proteins cluster around muscle development and the assembly of the contractile apparatus. Other terms like nervous system development and renal morphogenesis appear but are less central, so the label emphasizes the core muscle-related function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:1900242","count":14},{"id":"GO:0045214","count":14},{"id":"GO:0072156","count":14},{"id":"GO:0007399","count":14}]},{"hash":"1171304050464458729","title":"Skeletal muscle development and sarcomere organization","description":"The cluster is strongly enriched for skeletal muscle\u2013related processes: sarcomere organization, skeletal muscle tissue development, and skeletal muscle cell differentiation, with ubiquitin-dependent protein catabolic processes prevalent as a core mechanism. This points to a muscle formation/maintenance program that also uses ubiquitin-mediated turnover; the other morphogenesis terms likely reflect broader roles of some members rather than a different primary theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":26},{"id":"GO:1900242","count":19},{"id":"GO:0045214","count":19},{"id":"GO:0072156","count":19},{"id":"GO:0007399","count":19}]},{"hash":"718108321443623354","title":"Systemic signaling and immune regulation","description":"The terms point to a broad network of signaling pathways spanning neural/neuroendocrine (photoreceptor maintenance, opioid signaling, CB/PKA activity), endocrine (vasopressin regulation of blood pressure), immune (IL-1beta production, dendritic cell differentiation), and other systemic processes (temperature response, coagulation, sensitization). This suggests a cluster driven by general signaling and regulation across systems rather than a single specific pathway, hence the label \u201cSystemic signaling and immune regulation.\u201d ","confidence":"Medium","size":26,"edges":113,"triangles":182,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":26},{"id":"GO:0001992","count":26},{"id":"GO:0071502","count":26},{"id":"GO:0032651","count":26},{"id":"GO:0097029","count":26}]},{"hash":"1467040320636355242","title":"Developmental ECM signaling and angiogenesis","description":"This cluster centers on tissue morphogenesis and extracellular matrix signaling (nipple morphogenesis, lung connective tissue development, ECM-cell signaling) with recurrent angiogenic regulation and key signaling pathways (Wnt, GPCR) and related endocytic processes, indicating a cohesive theme of ECM-driven development and blood vessel formation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060658","count":4},{"id":"GO:0060427","count":4},{"id":"GO:1902966","count":3},{"id":"GO:0035426","count":3},{"id":"GO:0007189","count":3}]},{"hash":"1663042242324644526","title":"Neural adhesion and axon guidance","description":"This cluster centers on neural development and cell\u2013cell interactions, with GO terms for cell adhesion, collagen fibril organization, lamellipodium assembly, sensory neuron axon guidance, and multicellular development, plus neural signaling aspects like clustering of voltage-gated sodium channels and vocalization behavior. A few immune sensing terms are present but do not define the main theme. Confidence: Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0045162","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0010592","count":2}]},{"hash":"117692122447157165","title":"Ubiquitin-Mediated Immune Regulation","description":"The top terms cluster around deubiquitination across multiple ubiquitin linkages (K6, K11, K29, K48) and proteolysis, combined with immune-related terms such as cellular response to interleukin-1 and adaptive immune response. This points to a functional group of proteins that regulate protein stability and degradation in immune signaling pathways. Some terms (e.g., salivary gland morphogenesis) appear tangential, likely reflecting multifunctional proteins or annotation noise, but the core theme is ubiquitin-dependent regulation of immune responses.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0071347","count":2},{"id":"GO:0044313","count":2},{"id":"GO:0035523","count":2},{"id":"GO:0035871","count":2}]},{"hash":"1747987575803557747","title":"Signaling and chromatin regulation","description":"The top GO terms cluster around modulation of signaling pathways (negative regulation of IGF receptor signaling, TNF-mediated signaling, I-kappaB phosphorylation) together with chromatin- and ubiquitin-related processes (histone deubiquitination, histone turnover, ubiquitin-dependent proteolysis, RITS complex assembly). This points to a theme where signaling control is integrated with transcriptional/chromatin regulation and protein turnover, with related stress-response hints (glucose starvation, histidine) and neuronal projection involvement. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043569","count":2},{"id":"GO:0033209","count":2},{"id":"GO:1904802","count":1},{"id":"GO:0016578","count":1},{"id":"GO:0071232","count":1}]},{"hash":"899929577973509199","title":"Embryogenesis and placental morphogenesis","description":"The cluster is dominated by embryonic development and tissue patterning terms: trophoblast giant cell differentiation, left/right pattern formation, endocrine system development, EMT in heart cushion formation, and placental development regulation, with cartilage morphogenesis supporting a broader morphogenesis theme. A plant-related term (pollen tube growth) appears but does not define the core function. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":17},{"id":"GO:0060972","count":16},{"id":"GO:0003323","count":16},{"id":"GO:0035270","count":16},{"id":"GO:0003198","count":16}]},{"hash":"1285771864316851177","title":"Unknown","description":"The top GO terms span disparate biological areas (cell growth, spindle assembly, telomere maintenance) as well as nervous system, heart development, pain sensing, and plant signaling. Because there isn't a single cohesive theme tying these proteins together\u2014and several entries are flagged as obsolete\u2014the cluster lacks a clear, interpretable function label.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":5},{"id":"GO:0050968","count":4},{"id":"GO:1900383","count":4},{"id":"GO:0051225","count":4},{"id":"GO:0007253","count":4}]},{"hash":"1089213631525874531","title":"Placental and Embryonic Development with ECM Remodeling","description":"The cluster mainly centers on placental and embryonic development (trophoblast differentiation, embryo implantation, endocrine system development) and EMT-associated processes, with a strong signal of extracellular matrix remodeling (collagen fibril organization, cartilage morphogenesis). A few terms point to broader embryogenesis, such as left\u2013right pattern formation, while complement activation hints at immune aspects of pregnancy.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0060707","count":12},{"id":"GO:0003323","count":11},{"id":"GO:0003198","count":11},{"id":"GO:0060972","count":10},{"id":"GO:0035270","count":10}]},{"hash":"1125304999792994078","title":"Signaling, cell cycle, and sensory perception","description":"This cluster includes GO terms for mitotic cell cycle, visual perception, pheromone response, Hippo signaling regulation, receptor recycling, budding growth, and GTPase activity regulation. These terms point to proteins involved in signaling networks that regulate growth and division, plus sensory signal processing, with trafficking processes (receptor recycling) supporting receptor availability. The label captures a cohesive theme of cell signaling and growth with sensory cues.","confidence":"Medium","size":25,"edges":287,"triangles":2026,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":14},{"id":"GO:0007601","count":14},{"id":"GO:0019236","count":11},{"id":"GO:0035330","count":11},{"id":"GO:0006547","count":11}]},{"hash":"1369034669361491395","title":"Immune activation and leukocyte recruitment","description":"The top GO terms show strong signals for innate immune processes: complement activation (lectin pathway), phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and cellular responses to fungal molecules. While several development-related terms are present, the immune-related terms dominate, suggesting the cluster mainly captures immune activation and leukocyte engagement. Confidence: High","confidence":"","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":25},{"id":"GO:0072177","count":24},{"id":"GO:0006910","count":24},{"id":"GO:0072218","count":24},{"id":"GO:0050901","count":24}]},{"hash":"1962646009294323542","title":"Leukocyte adhesion and complement activation","description":"The cluster is dominated by immune-related terms such as complement activation (lectin pathway), leukocyte tethering/rolling, phagocytosis recognition, and regulation of cell adhesion molecule production, with some developmental terms (lymph vessel morphogenesis, mesonephric duct development) that are less central. This points to a cohesive theme around immune cell recruitment and activation, though there is some overlap with development, so the label is representative but not exclusive.","confidence":"Medium","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0001867","count":25},{"id":"GO:0050901","count":21},{"id":"GO:0001502","count":21},{"id":"GO:0060355","count":21},{"id":"GO:0010572","count":21}]},{"hash":"2053082421204477351","title":"Placental and Embryonic Development","description":"The cluster is dominated by GO terms for trophoblast giant cell differentiation, placental and embryonic development, left-right patterning, and EMT-related processes, indicating a coherent focus on placental/embryonic morphogenesis and tissue patterning. Some terms are broader or less specific (e.g., obsolete or unrelated pathways) but do not override the main theme.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0060707","count":9},{"id":"GO:0060972","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003198","count":8}]},{"hash":"426113955182725617","title":"Innate Immune Signaling and Apoptosis Regulation","description":"The cluster centers on innate immune response, inflammatory pyroptosis, and regulation of apoptosis and ubiquitination, with supporting roles from integrin signaling, cell adhesion, and coagulation pathways. This suggests a cohesive theme of immune activation and controlled cell death, even though a single term on mitotic spindle assembly is less directly related.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0070269","count":6},{"id":"GO:1990001","count":6},{"id":"GO:0006915","count":6}]},{"hash":"1741443096139288312","title":"Neuronal signaling and sensory processing","description":"These terms converge on neural excitability and communication: ion transmembrane transport maintains membrane potential, neurotransmission via GABA and EPSP, and sensory/behavioral terms (sound detection, startle, circadian regulation) reflect neural circuit function.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":17},{"id":"GO:0060079","count":15},{"id":"GO:0071805","count":14},{"id":"GO:0001661","count":13},{"id":"GO:0007626","count":13}]},{"hash":"2050461338652390537","title":"ERAD and autophagy-linked protein quality control","description":"The cluster is dominated by GO terms related to ubiquitin-dependent degradation and ER-associated degradation (ERAD), including deubiquitination and aggrephagy, with supporting signals of autophagy regulation and endocytic control. This points to a cohesive module centered on protein quality control via ubiquitin-proteasome and autophagy pathways.","confidence":"High","size":25,"edges":196,"triangles":709,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:0030433","count":8},{"id":"GO:1904378","count":8},{"id":"GO:1900186","count":7},{"id":"GO:1901340","count":7}]},{"hash":"1635393624557362210","title":"Developmental signaling and organogenesis","description":"The cluster\u2019s top GO terms cluster around developmental processes across multiple tissues (nervous system development, neurogenesis, heart and kidney development, vagina development) and key signaling pathways (Smoothened/SHH, Roundabout/ROBO), with apoptosis and proliferation regulation also represented. This suggests proteins involved in broad developmental signaling and organogenesis rather than a single specific function.","confidence":"High","size":25,"edges":289,"triangles":2068,"max_degree":24,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0050852","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0006915","count":13},{"id":"GO:0022008","count":13},{"id":"GO:0060068","count":13}]},{"hash":"848508454287300693","title":"Neural development and radial glial scaffolding","description":"The top GO terms include brain development, forebrain radial glial differentiation, and formation of radial glial scaffolds, all pointing to neural development and glial architecture. Additional terms like cochlea morphogenesis and liver development appear but are less central. The strongest theme is neural progenitor differentiation and the structural scaffolding provided by radial glia, with anti-apoptotic and stress-related terms supporting neural tissue maintenance. Therefore, this label captures the core function of the cluster.","confidence":"High","size":25,"edges":73,"triangles":113,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043124","count":17},{"id":"GO:0001889","count":17},{"id":"GO:1902236","count":17},{"id":"GO:0035690","count":17},{"id":"GO:0090103","count":17}]},{"hash":"6701119372171071","title":"Developmental signaling and differentiation","description":"The top GO terms highlight Wnt signaling, transcriptional regulation, and morphogenesis across neural and epidermal tissues within multicellular development, with additional signs of proliferation and basic ion transport, suggesting a cluster of proteins involved in developmental signaling and cell differentiation rather than a single specific pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043552","count":19},{"id":"GO:0006351","count":19},{"id":"GO:0090263","count":19},{"id":"GO:0048813","count":19},{"id":"GO:0007275","count":18}]},{"hash":"2091858136772749095","title":"Developmental transcription and differentiation","description":"Top GO terms point to embryonic development and lineage-specific differentiation (in utero embryonic development, mammary gland alveolus development, Leydig cell differentiation) along with DNA-templated transcription, suggesting the core theme is transcriptional control guiding developmental fate. Other terms reflect regulatory processes (NF-kappaB, interferon signaling) and metabolism/stress responses that accompany development, but the dominant signal remains developmental transcriptional regulation.","confidence":"Medium","size":25,"edges":96,"triangles":150,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":11},{"id":"GO:0060336","count":10},{"id":"GO:0060749","count":10},{"id":"GO:0033327","count":10},{"id":"GO:0006351","count":10}]},{"hash":"1299985666414682388","title":"DNA replication and cell cycle regulation","description":"The top GO terms are dominated by nuclear processes: DNA-templated transcription, DNA replication, the mitotic cell cycle, and DNA repair, pointing to genome maintenance and cell division as the core functions. While there are secondary terms involving signaling and exocytosis, they appear peripheral to the main DNA-centric theme. ","confidence":"High","size":25,"edges":114,"triangles":154,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":24},{"id":"GO:0006260","count":24},{"id":"GO:0000278","count":24},{"id":"GO:0006281","count":23},{"id":"GO:0031532","count":22}]},{"hash":"733226537401571037","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":87,"triangles":79,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000466","count":8},{"id":"GO:0000463","count":8},{"id":"GO:0000398","count":7},{"id":"GO:0000472","count":7},{"id":"GO:0042273","count":7}]},{"hash":"2303339828188613416","title":"Chromatin regulation and transcription control","description":"This cluster is dominated by chromatin-related processes: negative regulation of transcription by RNA polymerase II, heterochromatin formation, chromatin remodeling associated with transcription initiation, and protein localization to chromatin, plus regulation of rRNA transcription by RNA polymerase I. Together these terms point to a cohesive theme of chromatin dynamics and transcription control. A few terms (vitellogenesis, osteoblast differentiation, defense response) are less central, likely reflecting ancillary roles or broader annotations, but do not override the primary chromatin/transcription focus.","confidence":"Medium","size":25,"edges":250,"triangles":1403,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":16},{"id":"GO:0030466","count":15},{"id":"GO:0050830","count":15},{"id":"GO:0071169","count":15},{"id":"GO:0007296","count":14}]},{"hash":"1628739370464183742","title":"Cholesterol Metabolism and Homeostasis","description":"The top GO terms are dominated by cholesterol-related processes (biosynthesis, intestinal absorption, homeostasis, cellular response to cholesterol) and related lipid pathways (sphingolipid metabolism), indicating a cohesive focus on cholesterol and lipid metabolism. Some terms like molting and brain development may reflect broader roles of lipids or annotation nuances, but the strongest theme centers on cholesterol metabolism.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006695","count":8},{"id":"GO:0008542","count":8},{"id":"GO:0040015","count":6},{"id":"GO:0030299","count":6},{"id":"GO:0071397","count":6}]},{"hash":"894362574324518734","title":"Transmembrane nutrient and ion transporters","description":"These proteins are strongly associated with transport across membranes, as shown by GO terms for xenobiotic, vitamin, and sugar transmembrane transport, plus sodium- and potassium-dependent ion transport and neurotransmitter loading into vesicles. The substrate diversity centers on membrane transport activity, suggesting the cluster represents transporter proteins handling nutrients, ions, and related substrates. ","confidence":"High","size":25,"edges":255,"triangles":1447,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":25},{"id":"GO:0035461","count":25},{"id":"GO:0071805","count":24},{"id":"GO:0042908","count":24},{"id":"GO:0042891","count":17}]},{"hash":"899390041006678632","title":"Dopaminergic visual perception and cocaine response","description":"The cluster\u2019s top GO terms are dominated by nervous-system functions related to vision (visual perception and learning) and dopaminergic synaptic transmission, with a notable behavioral response to cocaine, suggesting a core theme of dopamine-mediated neural signaling and sensory processing. ERK pathway regulation appears as a downstream signaling link. Some terms like heart development and macrophage chemotaxis are broader or pleiotropic, but they do not override the primary neural/sensory emphasis.","confidence":"Medium","size":25,"edges":244,"triangles":1228,"max_degree":23,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":22},{"id":"GO:0007507","count":20},{"id":"GO:0019233","count":20},{"id":"GO:0071380","count":20},{"id":"GO:0070374","count":20}]},{"hash":"129835154247444815","title":"Mixed sensory and immune signaling","description":"The top GO terms point to sensory perception of stimuli (temperature, chemical/pain), vestibular development, and electrical signaling (potassium export, cardiac action potential), alongside immune-related terms (T cell homeostasis, cytokine production). This suggests a broad signaling/excitability theme spanning sensory/neural contexts with immune modulation, rather than a single cohesive pathway, hence a label focused on mixed sensory and immune signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":4},{"id":"GO:0043029","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0097623","count":3}]},{"hash":"525131713489856248","title":"Translation initiation and reinitiation machinery","description":"This cluster is dominated by GO terms for translation initiation, reinitiation, and related processes (including IRES-dependent viral initiation and preinitiation complex formation), suggesting a shared function in ribosome recruitment and start of translation. A couple of outlier terms (blastocyst formation, ncRNA-mediated silencing) appear incidental to the main theme but do not override the translation-centric signal.","confidence":"High","size":25,"edges":122,"triangles":298,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0075525","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0075522","count":4}]},{"hash":"1193186292282657983","title":"ECM\u2013Integrin Adhesion and Angiogenesis","description":"The top GO terms cluster around extracellular matrix (ECM) organization, cell adhesion, and integrin-mediated signaling, with accompanying processes in angiogenesis and platelet activation. This points to a cohesive theme of ECM-driven cell interactions promoting vascular development. A few terms about memory or glutamatergic transmission are present but less representative of the main theme.","confidence":"Medium","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0045715","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0051968","count":3}]},{"hash":"2284944904067316927","title":"Craniofacial and endocrine organ development","description":"This cluster is dominated by developmental GO terms: roof of mouth development, left/right pattern formation, pancreatic cell development, and endocrine system development, pointing to a theme of craniofacial and endocrine organogenesis. Additional terms for RNA processing and DNA repair suggest some housekeeping roles among members, but the strongest signal is embryonic patterning and organ development.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":20},{"id":"GO:0060972","count":15},{"id":"GO:0042542","count":15},{"id":"GO:0003323","count":15},{"id":"GO:0035270","count":15}]},{"hash":"1385053928412584378","title":"Prostaglandin biosynthesis and anti-inflammatory signaling","description":"The top GO term is prostaglandin biosynthetic process, with all 25 proteins linked, and several terms reflecting suppression of inflammatory signaling (negative regulation of NF-kappaB, ERK1/2, and JNK cascades; reduced MCP-1 production) plus glucocorticoid response. Additional terms about type II pneumocyte differentiation and glutathione derivative biosynthesis support a context of lung-related immune regulation and redox balance. Together they point to a coherent function center on prostaglandin production coupled with anti-inflammatory control.","confidence":"High","size":25,"edges":295,"triangles":2192,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":25},{"id":"GO:0035726","count":20},{"id":"GO:0043124","count":20},{"id":"GO:0071385","count":20},{"id":"GO:0070373","count":20}]},{"hash":"1995299450950904412","title":"Adaptive Immune Signaling and Cell Adhesion","description":"The cluster\u2019s top GO terms cluster around adaptive immunity\u2014B cell receptor signaling, T cell receptor signaling regulation, and adaptive immune response\u2014supported by cell\u2013cell adhesion and cytokine production terms. Some terms (heart development, mechanical stimulus) may reflect tissue context but do not dominate; the immune signaling theme is strongest.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0016337","count":2},{"id":"GO:0033146","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1427868573525759092","title":"Neuronal synapse assembly and neurotransmission","description":"This cluster is dominated by GO terms tied to synapse structure and function, including synaptic vesicle clustering, neurexin clustering in presynaptic membranes, and regulation of receptor recycling, along with negative regulation of neurotransmission. Retina development and glucocorticoid response further support neural-related processes, suggesting a cohesive theme around presynaptic organization and neurotransmitter signaling, despite a few outliers. ","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060041","count":14},{"id":"GO:0097091","count":13},{"id":"GO:0051384","count":13},{"id":"GO:0045212","count":13},{"id":"GO:0002076","count":13}]},{"hash":"231389599314924222","title":"Embryonic development and organ morphogenesis","description":"The GO terms cluster around embryonic development and organ/tissue morphogenesis, including left/right patterning, endocrine system development, placenta-related differentiation, cartilage morphogenesis, and EMT processes; supported by transcription and chromatin remodeling terms that reflect developmental gene regulation. This combination suggests a cohesive role in embryonic development and organ formation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060707","count":7}]},{"hash":"2083341385802029654","title":"Embryonic Organ Development","description":"The proteins are enriched in GO terms spanning development of multiple organs and embryogenesis (pituitary gland, heart, eye morphogenesis, prostate morphogenesis, male gonad, in utero development), plus broader multicellular organism development and transcription regulation. This pattern points to a cluster of factors involved in organogenesis and embryonic morphogenesis across diverse tissues rather than a single pathway.","confidence":"High","size":25,"edges":22,"triangles":1,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":12},{"id":"GO:0007507","count":11},{"id":"GO:0000122","count":11},{"id":"GO:0007275","count":10},{"id":"GO:0048048","count":10}]},{"hash":"1243496434393106587","title":"Embryonic Development and Patterning","description":"This cluster shows strong representation of developmental processes across multiple tissues (left-right pattern formation, primitive streak formation, midbrain and peripheral nervous system neuron development, pituitary gland development, multicellular organism development) along with transcriptional regulation terms, indicating proteins involved in embryogenesis and gene expression control during patterning and organogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0030851","count":5},{"id":"GO:0045648","count":5},{"id":"GO:0006366","count":5},{"id":"GO:0090009","count":5}]},{"hash":"284162257454542429","title":"Unknown","description":"The terms span diverse biological processes (angiogenesis, collagen organization, immune signaling, reproductive development, neuronal development, bone resorption, and mechanotransduction) with no single cohesive theme. With no network connectivity (Edges 0, Triangles 0), the cluster appears to group heterogeneous functions rather than a shared pathway, so a concise representative label cannot be derived.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016525","count":11},{"id":"GO:0030199","count":11},{"id":"GO:0051092","count":11},{"id":"GO:0060065","count":11},{"id":"GO:0002322","count":10}]},{"hash":"1145303768257860803","title":"Retina Development and Photoreceptor Differentiation","description":"The dominant terms describe eye biology: visual perception, retina vasculature development in the camera-type eye, and photoreceptor differentiation, with Notch signaling regulation. Additional junction-related terms and receptor internalization support signaling and cellular organization in retinal tissue. This combination points to a coherent role in retina formation and photoreceptor maturation.","confidence":"High","size":25,"edges":28,"triangles":0,"max_degree":22,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045747","count":9},{"id":"GO:0030913","count":9},{"id":"GO:0007601","count":8},{"id":"GO:0030886","count":7},{"id":"GO:0060219","count":7}]},{"hash":"1228998982485094762","title":"Plasma Membrane Transporters","description":"The cluster is dominated by transmembrane transport GO terms for various substrates (pantothenate, myo-inositol, glucose, biotin, sodium), indicating a cohesive set of membrane transporter proteins. Immune-related terms appear but are secondary, suggesting some functional links to signaling or cell interactions but the primary theme is transport across the plasma membrane.","confidence":"High","size":25,"edges":145,"triangles":553,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0008292","count":5},{"id":"GO:0015887","count":5},{"id":"GO:0015798","count":5},{"id":"GO:1904659","count":5},{"id":"GO:0015878","count":5}]},{"hash":"1325827523671777761","title":"Axon guidance and myelination in neural development","description":"These terms point to neuronal development and wiring: axonogenesis, axonal fasciculation, axon extension, and synapse assembly, along with myelination, suggesting roles in forming and insulating neural circuits. The presence of innate immune and TLR9 signaling terms may reflect neural-immune interactions (e.g., microglia signaling). A few terms (otolith morphogenesis) indicate broader developmental roles, but the dominant theme is axon guidance and myelination during neural development.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042552","count":5},{"id":"GO:0032474","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0006469","count":5}]},{"hash":"1813776155789547803","title":"Membrane Transporters and Signaling Proteins","description":"These proteins show a membrane-centric theme: transmembrane transport terms (nitrite, ammonium, xenobiotic transport), cell adhesion and neuronal membrane organization (cell adhesion, dendritic spine development, sodium channel clustering), and signaling pathway modulation (EGFR and Wnt). While diverse, the shared thread is membrane-associated transport combined with signaling/adhesion roles rather than a single enzyme or immune-specific function. Medium","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0070634","count":2},{"id":"GO:0060996","count":2},{"id":"GO:0042058","count":2}]},{"hash":"2291604003820329016","title":"Ubiquitin-Dependent Regulation of Development and Immunity","description":"Dominant term is ubiquitin-dependent protein catabolic process, with additional terms spanning circadian rhythm, nervous system development, skeletal muscle differentiation, and various immune signaling processes. This points to a set of proteins involved in ubiquitin-mediated proteostasis that broadly modulates development, neural/muscle function, and immune responses. The cluster does not map to a single tight pathway but to a common mechanism of regulated protein turnover affecting multiple biological contexts.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0042752","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0035914","count":10},{"id":"GO:0048294","count":9}]},{"hash":"1923317007059490798","title":"Genome maintenance: DNA replication/repair and cell cycle control","description":"Proteins in this cluster are enriched for DNA recombination, DNA replication, base-excision repair, and regulators of the G1/S transition, indicating a core function in genome maintenance. Additional terms for mRNA stability regulation and redox homeostasis suggest coordination with transcriptional/post-transcriptional control and cellular stress responses, with broader axes of xenobiotic response and cAMP signaling providing contextual signaling links. The dominant theme is genome integrity maintenance and cell-cycle control.","confidence":"High","size":25,"edges":183,"triangles":609,"max_degree":23,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":11},{"id":"GO:0006260","count":8},{"id":"GO:0042493","count":7},{"id":"GO:0006284","count":7},{"id":"GO:0043488","count":6}]},{"hash":"1917708776475551538","title":"Retinoid Metabolism and Organ Development","description":"Top GO terms are dominated by retinol metabolic process and retinal metabolic process, indicating a strong retinoid metabolism signal. Several development-related terms cluster around organ formation, notably cardiac muscle tissue development, midgut and pancreas development, and embryonic digestive tract development, suggesting retinoid signaling may coordinate early organogenesis in the digestive tract and heart. A few additional terms (glucosylceramide metabolic process, ubiquinone biosynthetic process) are present but do not define the main theme. Overall, the group centers on retinoid metabolism with a developmental context.","confidence":"High","size":25,"edges":299,"triangles":2277,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":22},{"id":"GO:0042574","count":22},{"id":"GO:0048738","count":14},{"id":"GO:0007584","count":14},{"id":"GO:0009954","count":14}]},{"hash":"298080239202678411","title":"Axon guidance and neural crest migration","description":"This cluster is dominated by GO terms for axon guidance, neuron projection, trigeminal nerve structure, neural crest migration, and semaphorin-plexin signaling, indicating a cohesive neural development theme centered on axon pathfinding and neural crest movement; a complement activation term appears but is less representative of the main function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":8},{"id":"GO:0097490","count":7},{"id":"GO:0021785","count":7},{"id":"GO:1902287","count":7},{"id":"GO:0021637","count":7}]},{"hash":"584502527456242308","title":"Glycan and polymer biosynthesis","description":"The cluster is enriched for GO terms pointing to biosynthesis of sugars and polysaccharide-containing polymers (galactose, GDP-mannose, LPS core, O antigen, colanic acid) and polymeric plant metabolites (phenylpropanoid and anthocyanin) as well as sporopollenin. This suggests a common theme of assembling complex carbohydrate polymers and related polymers rather than a single enzyme activity. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006541","count":5},{"id":"GO:0006012","count":5},{"id":"GO:0009699","count":5},{"id":"GO:0009718","count":5},{"id":"GO:0009242","count":5}]},{"hash":"1054758104479111874","title":"Hearing and Balance Neural Signaling","description":"The top GO terms point to sensory perception of sound, vestibular nerve development, startle and other reflexive/motor responses, and various neurotransmitter signaling pathways (acetylcholine, GABA, serotonin), plus neuromuscular control. This pattern suggests a coherent functional theme around auditory-vestibular neural signaling and related sensory-motor pathways.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0050884","count":3},{"id":"GO:0051970","count":2},{"id":"GO:0001661","count":2},{"id":"GO:0095500","count":2}]},{"hash":"415258731231700414","title":"Cell growth, division, and vesicle transport","description":"The terms point to core eukaryotic processes: cell division and multicellular development, plus ER-to-Golgi vesicle transport, TORC1 signaling, and regulation of GTPase activity and phosphorylation. These collectively suggest coordinated growth, proliferation, and intracellular trafficking, with some older methionine salvage terms likely historical annotations. Confidence: Medium.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0006909","count":3},{"id":"GO:0038202","count":3}]},{"hash":"628114306338636229","title":"Thermal and Immune Stress Response","description":"This cluster groups proteins linked to temperature- and thermogenesis-related processes (cellular response to temperature stimulus; diet-induced thermogenesis) alongside immune-related activities (immune response; regulation of IL-1 beta production; dendritic cell differentiation) and tissue remodeling signals (bone remodeling) as well as endocrine cues (vasopressin-regulated blood pressure) and maintenance signals (photoreceptor cell maintenance). The common thread appears to be an integrated, system-wide stress response that coordinates metabolic, immune, and hormonal pathways rather than a single, isolated pathway, though some terms (like photoreceptor maintenance) are more context-specific. ","confidence":"Medium","size":25,"edges":27,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0019233","count":16},{"id":"GO:0006955","count":15},{"id":"GO:0046849","count":15}]},{"hash":"1875919279231117866","title":"Embryogenesis and organ morphogenesis","description":"GO terms dominated by embryonic development and organ formation processes, including endocrine system development, cartilage morphogenesis, EMT in heart cushion formation, placental and pancreatic development, and left-right patterning, suggest this cluster centers on embryogenesis and tissue morphogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":8},{"id":"GO:0060536","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060707","count":8},{"id":"GO:0060806","count":8}]},{"hash":"1722217328074513008","title":"Cartilage development and proteoglycan biosynthesis","description":"The cluster shows enrichment for cartilage-related processes, including cartilage development and chondroitin sulfate proteoglycan biosynthesis, with skeletal muscle fiber development also pointing to connective tissue/matrix-related functions. While several terms are broad or obsolete, the cartilage proteoglycan/matrix theme is the strongest signal tying the set together.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000002","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0070940","count":2},{"id":"GO:0050728","count":2},{"id":"GO:0048741","count":2}]},{"hash":"773841454739505003","title":"Cardiovascular signaling and inflammatory responses","description":"The cluster centers on signaling pathways that regulate blood pressure and coagulation, calcium release, and immune cell recruitment (neutrophil chemotaxis, pain perception), with supporting terms for GPCR signaling, Rho signaling, and stress/metabolic responses (temperature, thermogenesis, electron transport). This suggests a theme of vascular-related signaling and inflammation under stress conditions, rather than a single narrow function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0035025","count":7},{"id":"GO:0007596","count":6}]},{"hash":"1429905576592536176","title":"Angiogenesis and Platelet-Immune Signaling","description":"The GO terms show angiogenesis, platelet activation/aggregation, adaptive immune response, collagen fibril organization, and skeletal development, plus ERK signaling and cytokine regulation, suggesting a cohesive theme of vascular remodeling with platelet and immune interaction and ECM involvement.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034116","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0002740","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0090331","count":3}]},{"hash":"2060719652023377681","title":"Angiogenesis and skeletal development with immune regulation","description":"The cluster centers on processes related to blood vessel formation and skeletal tissue formation (sprouting angiogenesis, growth plate cartilage development, bone trabecula formation, regulation of endothelial proliferation, fibrinolysis). It also includes immune signaling components (TNF production, neutrophil chemotaxis, dendritic cell antigen processing), suggesting coordination between vascular, skeletal, and immune remodeling. ","confidence":"High","size":25,"edges":125,"triangles":371,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051918","count":12},{"id":"GO:0030511","count":11},{"id":"GO:0016525","count":11},{"id":"GO:0042535","count":11},{"id":"GO:0003417","count":10}]},{"hash":"1246196744162722119","title":"Neural development and innate immune signaling","description":"The top terms emphasize neural development processes (positive regulation of synapse assembly, myelination, axonal fasciculation, otolith morphogenesis) alongside innate immune responses (defense against Gram-positive/Gram-negative bacteria, cellular response to LPS). This suggests a cluster of proteins involved in nervous system maturation with immune signaling or cross-talk, though some terms (e.g., uterus development) may reflect pleiotropy or annotation breadth. Overall, the theme centers on neural development with immune-related roles.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":16},{"id":"GO:0042552","count":15},{"id":"GO:0032474","count":15},{"id":"GO:0050830","count":15},{"id":"GO:0045087","count":15}]},{"hash":"1543470839578055625","title":"GPCR-driven vascular and immune signaling","description":"The top GO terms cluster around GPCR signaling that activates adenylate cyclase, with strong ties to vascular regulation (blood pressure, vasopressin) and immune/hemostatic processes (platelet activation, Rho signaling, dendritic cell differentiation, IL-1\u03b2 regulation). While some terms like the electron transport chain and photoreceptor maintenance are broader cellular processes and less directly tied to this theme, the dominant signal is GPCR-mediated signaling affecting vascular and immune functions. Confidence: Medium","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":6},{"id":"GO:0022900","count":6},{"id":"GO:0045777","count":6},{"id":"GO:0035025","count":5},{"id":"GO:0030168","count":5}]},{"hash":"144867474137499483","title":"Mitochondrial Regulation and Growth Signaling","description":"The top GO terms point to mitochondrial regulation (membrane potential, mitochondrial DNA metabolism), oxidative stress response, and growth-related signaling (PI3K/AKT, cyclin-dependent kinase activity) plus epithelial proliferation and actomyosin contractile ring localization, suggesting a common theme of energy-regulated growth signaling and cytoskeletal organization.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051881","count":2},{"id":"GO:1904120","count":1},{"id":"GO:0050679","count":1},{"id":"GO:1990179","count":1},{"id":"GO:1901858","count":1}]},{"hash":"133866457943642216","title":"Telomere maintenance regulators","description":"The top GO terms are dominated by telomere-related processes: regulation of telomere maintenance via telomerase, telomere length regulation, telomeric region localization, and related chromosomal telomere activities, with secondary links to chromosome segregation during mitosis. While a few terms touch on other signaling areas, the core, recurring theme across the cluster is telomere biology and maintenance.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":6},{"id":"GO:0051225","count":6},{"id":"GO:0032212","count":6},{"id":"GO:1904743","count":6},{"id":"GO:0070213","count":6}]},{"hash":"1902577503558015037","title":"Developmental Patterning and Gene Regulation","description":"The GO terms point to key developmental processes (mesoderm development, left-right pattern formation, hair follicle morphogenesis, endocardial cushion formation) alongside gene expression control (mRNA splicing, spliceosome activity, RNA Pol II regulatory region binding, DNA-templated replication initiation). This suggests a cluster of proteins coordinating developmental patterning with transcriptional and RNA processing regulation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010957","count":25},{"id":"GO:0003198","count":25},{"id":"GO:0000398","count":25},{"id":"GO:1903026","count":25},{"id":"GO:0031069","count":25}]},{"hash":"1365997003964964811","title":"Fungal innate immune response via lectin pathway","description":"The top terms cluster around innate immunity against fungi: lectin pathway\u2013driven complement activation, C-type lectin receptor signaling, basophil activation, and phagocytosis recognition, suggesting a coherent theme of fungal recognition and immune activation. Some developmental terms appear but are likely secondary associations.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":19},{"id":"GO:0071226","count":13},{"id":"GO:0072218","count":12},{"id":"GO:0001502","count":12},{"id":"GO:0048008","count":11}]},{"hash":"1341379252015379507","title":"Surface Immune-Coagulation Proteins","description":"This cluster centers on GO terms for complement activation (lectin pathway) and blood coagulation, with protein localization to the cell surface and IL-6\u2013related signaling, suggesting surface-associated immune and coagulation components. The presence of ERAD/deglycosylation terms hints at protein processing in the secretory pathway, supporting a theme of extracellular immune-coagulation factors with quality-control involvement.","confidence":"Medium","size":24,"edges":31,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:1904378","count":5},{"id":"GO:1902042","count":4},{"id":"GO:0034394","count":4},{"id":"GO:0072378","count":4}]},{"hash":"1659015955847438384","title":"Spliceosome-Driven mRNA Processing","description":"This cluster is dominated by GO terms tied to spliceosome activity and mRNA processing: positive/negative regulation of mRNA splicing via spliceosome, regulation of alternative splicing, and mRNA export and stabilization. The coherent theme points to a module of proteins coordinating post-transcriptional mRNA maturation and splicing regulation, with ncRNA-mediated gene silencing as a related regulatory layer. ","confidence":"High","size":24,"edges":264,"triangles":1772,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":17},{"id":"GO:0048026","count":17},{"id":"GO:0000381","count":15},{"id":"GO:0006406","count":15},{"id":"GO:1901407","count":15}]},{"hash":"76844317928218336","title":"ECM remodeling and morphogenesis","description":"This cluster's top GO terms point to extracellular matrix remodeling (collagen catabolic process, basement membrane disassembly) and morphogenesis (lung tube branching, ossification), with decidualization and thyroid hormone response contributing developmental signaling. An immune term (T cell cytotoxicity) appears but is less central, so the main theme is tissue remodeling during development.","confidence":"Medium","size":24,"edges":214,"triangles":1134,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0046697","count":19},{"id":"GO:0050790","count":19},{"id":"GO:0097067","count":19},{"id":"GO:0060441","count":19},{"id":"GO:0010813","count":19}]},{"hash":"604591738860350946","title":"DNA maintenance and organelle inheritance with cytoskeletal regulation","description":"This cluster centers on DNA metabolism (unwinding, replication, recombination, UV protection) and factors involved in inheritance processes (vacuole/mitochondrion inheritance) along with cytoskeletal and polarity-related activities (actin cortical patches, cell shape polarity). The mixture suggests a set of proteins coordinating genome maintenance with organelle inheritance and cytoskeleton dynamics, despite some obsolete GO terms in the mix.","confidence":"Medium","size":24,"edges":211,"triangles":1046,"max_degree":23,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032508","count":10},{"id":"GO:0006310","count":7},{"id":"GO:0006268","count":6},{"id":"GO:0071963","count":6},{"id":"GO:0000011","count":6}]},{"hash":"1090061207243467428","title":"Neural Pain and Drug Response Signaling","description":"The proteins are annotated with GO terms for sensory pain perception, dopamine regulation, morphine response, inflammatory processes, and MAPK signaling, pointing to neuronal signaling related to pain, reward, and drug response. Despite no observed edges, the recurring brain-related processes provide a coherent theme for the cluster. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0042755","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0042053","count":3},{"id":"GO:0007603","count":3}]},{"hash":"1826393340866745276","title":"Developmental signaling and lipid biosynthesis","description":"This cluster's top GO terms cluster around development-related processes (lung development; positive regulation of fibroblast migration) along with multiple biosynthetic pathways (retinoic acid, fatty acid, very long-chain fatty acids, poly-hydroxybutyrate, tropane alkaloids) and a transcription regulation term. While the terms span metabolism and signaling, the developmental signals (retinoic acid production, fibroblast migration, lung development) suggest a unifying theme of development-related signaling coupled with lipid/secondary metabolite biosynthesis. ","confidence":"Medium","size":24,"edges":49,"triangles":15,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":12},{"id":"GO:0055114","count":12},{"id":"GO:0010763","count":11},{"id":"GO:0030324","count":11},{"id":"GO:0006355","count":11}]},{"hash":"1106719114755796338","title":"Neural development and NF-kB\u2013mediated synaptic signaling","description":"The top GO terms emphasize nervous system development, synaptic transmission (glutamatergic), and synapse assembly, along with innate immune response and NF-kB pathway regulation, suggesting a cluster of proteins involved in neural development and synaptic function that also engage NF-kB\u2013related immune signaling. This name captures the shared themes of neuronal development and NF-kB\u2013associated signaling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0008542","count":4},{"id":"GO:0035249","count":4}]},{"hash":"372394513275133788","title":"Embryogenesis and RNA regulation","description":"This cluster centers on embryonic development terms (somite development, multicellular organism growth, blastocyst formation) and RNA processing/regulation (regulatory ncRNA-mediated gene silencing, mRNA stabilization, polyadenylation-related terms). The presence of both developmental and post-transcriptional regulation hints at proteins involved in early development with RNA-level control. The low connectivity suggests a broad, possibly loosely related set rather than a single pathway, but the overarching theme remains developmental progression linked to RNA regulation.","confidence":"Medium","size":24,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061053","count":3},{"id":"GO:0060445","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0072756","count":2},{"id":"GO:0035264","count":2}]},{"hash":"1798908536239724864","title":"Developmental and Immune Signaling","description":"The cluster includes terms for neural differentiation and axon guidance, organ development (hair follicle, salivary gland), and cardiac activity, alongside immune-related terms (B cell signaling, immunoglobulin production, activation of membrane attack complex), indicating a broad mix of developmental processes and immune signaling rather than a single cohesive function.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0021859","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0086014","count":3},{"id":"GO:0042511","count":3},{"id":"GO:0051798","count":3}]},{"hash":"445368581504038857","title":"Leukocyte adhesion and integrin signaling","description":"The cluster\u2019s top GO terms cluster around immune-related adhesion and signaling processes: integrin-mediated signaling, heterotypic cell-cell adhesion, chemotaxis, and T cell activation, which together point to leukocyte adhesion and activation pathways. Transcription regulation terms are present but likely secondary to these adhesion/signaling themes, suggesting a core immune cell\u2013migration and signaling role rather than a transcription-centric function.","confidence":"Medium","size":24,"edges":15,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0006935","count":2}]},{"hash":"1349142931703199594","title":"Regulated protein transport and exocytosis","description":"The top GO terms center on protein transport, calcium-dependent exocytosis, and regulation of endocytosis, pointing to vesicle trafficking and controlled secretion as the core function; additional terms touch on cytokine production and neural/ganglion development, which may reflect broader signaling roles but do not override the trafficking theme.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":5},{"id":"GO:0045956","count":5},{"id":"GO:0045806","count":5},{"id":"GO:0050715","count":5},{"id":"GO:0061198","count":1}]},{"hash":"192616631732626899","title":"Metabolic Biosynthesis and Xenobiotic Response","description":"Based on the top GO terms, the cluster is enriched for metabolic biosynthesis and catabolic processes (e.g., propylene catabolic process, poly-hydroxybutyrate biosynthetic process, antibiotic biosynthetic process), together with a response to xenobiotic stimulus. This points to proteins involved in building or degrading small molecules and coping with foreign compounds, rather than a single signaling or structural pathway. Some terms (aging, protein amidation, stem cell proliferation, miRNA silencing) appear as annotations that may reflect broader regulatory roles or noise, but the core theme aligns with metabolism and detox/stress response.","confidence":"Medium","size":24,"edges":10,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0042208","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0042493","count":3}]},{"hash":"942462034392100623","title":"Extrinsic apoptotic signaling regulators","description":"The cluster shows multiple GO terms focused on regulation (both positive and negative) of the extrinsic apoptotic signaling pathway, including death receptor\u2013mediated processes (via death domain receptors), and tissue-specific contexts like B cell, hepatocyte, and spleen apoptosis. The proteins are likely modulators or regulators of death-receptor\u2013driven apoptosis rather than core execution components.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":3},{"id":"GO:0060546","count":3},{"id":"GO:2001240","count":3},{"id":"GO:0048536","count":3},{"id":"GO:0001783","count":3}]},{"hash":"193934607437933320","title":"Starch and sucrose metabolism with sugar response","description":"Based on the top GO terms, the cluster centers on carbohydrate biosynthesis and metabolism (starch, glycogen, sucrose) and related sugar-response processes (response to sucrose, feeding behavior, response to flooding). Some terms related to glycosylation and thiol biosynthesis appear as ancillary or cross-organism annotations, but the dominant theme is carbohydrate production and sugar signaling linked to stress responses. Overall, the connections between starch/sucrose pathways and stress-related GO terms support a cohesive interpretation.","confidence":"Medium","size":24,"edges":22,"triangles":1,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0019252","count":5},{"id":"GO:0005978","count":5},{"id":"GO:0005985","count":5},{"id":"GO:0007631","count":4},{"id":"GO:0033577","count":4}]},{"hash":"629413243692795066","title":"Neural development and synaptic signaling","description":"The top GO terms are dominated by neural-related processes, including retina development and several key synaptic functions (vesicle clustering, exocytosis, and localization to the synapse), with supporting signals like glucocorticoid response. Although osteoblast development appears, the prominent theme centers on neural development and synaptic signaling.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060041","count":21},{"id":"GO:0002076","count":20},{"id":"GO:0002087","count":20},{"id":"GO:1902474","count":19},{"id":"GO:0097091","count":19}]},{"hash":"1707463458235715261","title":"Innate Immune Signaling and GPCR Regulation","description":"The top GO terms cluster around antiviral/innate immune responses (interferon signaling, dsRNA response, defense against virus) and regulation of signaling pathways via G protein-coupled receptors, with additional related receptor-associated processes (morphine response, steroid receptor assembly). While a few terms (like photoreceptor localization and mitotic cell cycle) are less tightly aligned, the dominant theme is signaling combined with innate immune responses.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0043278","count":8},{"id":"GO:2001162","count":7},{"id":"GO:0071357","count":7},{"id":"GO:1903546","count":7},{"id":"GO:0008277","count":7}]},{"hash":"2273422905959161232","title":"Plant carbohydrate catabolism and developmental processes","description":"The top GO terms are dominated by carbohydrate metabolic and catabolic processes (carbohydrate metabolic process, glycoside and glycosylceramide catabolic processes) together with plant development terms (leaf morphogenesis, flower development). Additional terms like cell wall organization and infection structure formation hint at cell-wall remodeling contexts that can accompany growth; overall, the cluster appears to couple carbohydrate catabolism with developmental regulation, despite lack of network edges in this set. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":6},{"id":"GO:0046477","count":5},{"id":"GO:0045019","count":5},{"id":"GO:0016139","count":5},{"id":"GO:0009911","count":5}]},{"hash":"1750723978537339578","title":"Wnt Signaling and Telomere Regulation","description":"Top terms include the Wnt signaling pathway and both telomere lengthening and telomerase regulation, plus protein ADP-ribosylation and maintenance of protein localization in the plasma membrane. This points to a signaling/modification cluster with connections to telomere biology, suggesting a coherent theme around signaling processes that interface with telomere regulation. While there are additional signals like cellular responses to mechanical stimulus and vitamin D, the strongest shared function appears to be Wnt-driven signaling linked to telomere maintenance. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071260","count":10},{"id":"GO:0033280","count":10},{"id":"GO:1904357","count":9},{"id":"GO:0016055","count":9},{"id":"GO:0032088","count":9}]},{"hash":"1584795744398307881","title":"Mitotic cell cycle and interferon signaling","description":"The set centers on cell cycle control terms (mitotic cell cycle and metaphase/anaphase transition) and immune signaling (cellular response to type I interferon). While other terms point to receptor signaling and post-translational modifications, the stronger signals point to mitosis-related regulation and interferon-driven responses, suggesting a cluster of proteins involved in cell cycle regulation with aspects of immune signaling.","confidence":"Medium","size":24,"edges":17,"triangles":0,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:2001162","count":6},{"id":"GO:0071357","count":6},{"id":"GO:1903546","count":6},{"id":"GO:0008277","count":6},{"id":"GO:0006463","count":6}]},{"hash":"830927338613223880","title":"Transmembrane Transporters","description":"The top GO terms are dominated by various transmembrane transport processes across membranes for ions (potassium, sodium), nitrite/nitrate, xenobiotics, sialic acid, and vesicular neurotransmitter loading, pointing to a cluster of membrane transporter proteins with diverse substrates.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0035725","count":4},{"id":"GO:2001046","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0006855","count":3}]},{"hash":"180994217622988760","title":"Inflammation and innate immune signaling","description":"The top GO terms cluster around inflammatory response, defense against Gram-positive bacteria, and lipopolysaccharide signaling, with hints of NF-\u03baB and PI3K/AKT\u2013related signaling, all pointing to immune/inflammatory pathway activity under cellular stress. Some terms (like synapse assembly regulation) reflect shared signaling machinery, but the dominant theme is inflammation and innate immune signaling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0031663","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0051092","count":3}]},{"hash":"861539888077183107","title":"Xenobiotic and Stress Response with Lipid Biosynthesis and Methylation","description":"The cluster combines stress-related terms (response to immobilization stress) with xenobiotic response and catabolic processes, and also features multiple biosynthetic pathways for lipids and cofactors (phosphatidylcholine, ubiquinone, sterol) along with various RNA and histone methylation activities and ribosomal subunit export. This pattern suggests a coordinated cellular stress adaptation program that links detox/catabolic remodeling with regulation of gene expression and membrane/lipid metabolism.","confidence":"Medium","size":24,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":8},{"id":"GO:0035690","count":6},{"id":"GO:0042738","count":5},{"id":"GO:0006656","count":5},{"id":"GO:0006744","count":5}]},{"hash":"465881644981368832","title":"Thermoregulation and GPCR Signaling","description":"The cluster is enriched for temperature-related responses (cellular response to temperature, diet-induced thermogenesis), GPCR signaling (adenylate cyclase-activating pathway), membrane potential regulation, energy metabolism (electron transport chain), and cardiovascular regulation (blood pressure, vasopressin). Together these terms point to a module coordinating thermoregulatory signaling with energy and cardiovascular control, likely mediated via GPCR pathways. Some neuronal-related terms like pain perception and photoreceptor maintenance reflect broader neural signaling components, but the core theme remains thermoregulation and GPCR-driven signaling.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0010579","count":14},{"id":"GO:0002024","count":14},{"id":"GO:0022900","count":14}]},{"hash":"1571551198704265056","title":"Unknown","description":"The GO terms span broad developmental categories (multicellular development, bone ossification, pollen tube growth) along with sensory and metabolic processes (pain perception, olfactory nerve formation, temperature response, thermogenesis, glycosylation). This mix does not point to a single cohesive function or pathway for the protein cluster, so a specific label cannot be confidently assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0071502","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0043931","count":4}]},{"hash":"789542916051942771","title":"Myelin lipid biosynthesis and nervous development","description":"The strongest signals are myelin-related: GO:0042552 myelination and GO:0006682 galactosylceramide biosynthetic process, pointing to proteins involved in myelin lipid synthesis. Additional terms for skin development and multicellular organism development likely reflect broader roles in neural crest\u2013derived tissues and tissue maturation, while sensory perception and temperature response hints connect to nervous system function. Taken together, the cluster most plausibly reflects myelin formation and associated nervous system development.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":5},{"id":"GO:0006682","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0071502","count":3},{"id":"GO:0002024","count":3}]},{"hash":"333597479738088034","title":"Unknown","description":"Top terms span proteoglycan biosynthesis (obsolete), temperature and pain sensing, ion transport, vestibular development, immune regulation, and cardiac signaling, indicating no single cohesive theme for the cluster.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":6},{"id":"GO:0030206","count":6},{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5}]},{"hash":"884330485887137098","title":"Ubiquitin-regulated skeletal muscle development","description":"The top terms point to ubiquitin-dependent protein turnover (including K33-linked ubiquitination and negative regulation of ubiquitination) together with skeletal muscle differentiation processes (sarcomere organization, skeletal muscle cell differentiation, skeletal muscle tissue development). This combination supports a theme of ubiquitin-regulated pathways guiding muscle development, with a few kidney or nervous system terms likely reflecting broader tissue contexts.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0045214","count":13},{"id":"GO:0072156","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0035914","count":13}]},{"hash":"63113198080228959","title":"B Cell Activation and Germinal Center Formation","description":"Based on the top GO terms, the cluster is enriched for B cell receptor signaling, germinal center formation, and regulation of isotype switching to IgE, with additional immune-related terms such as type 2 immune response and pro-T cell differentiation, pointing to adaptive immune activation and GC biology. Some ubiquitin-dependent degradation and general protein interactions appear, but the dominant signal centers on B cell activation and germinal center processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0051260","count":10},{"id":"GO:0050853","count":8},{"id":"GO:0002467","count":8},{"id":"GO:0048294","count":7}]},{"hash":"1729380163578393758","title":"Glycinergic Neurotransmission and Amino Acid Transport","description":"Based on the GO terms, the cluster is dominated by glycine-related synaptic activity (glycinergic transmission, glycine import/export, and regulation of glycinergic transmission) and by transport of various amino acids (proline, leucine). Serotonin-related terms are present but secondary to the glycine/transport theme, suggesting a cohesive group of proteins involved in glycine-mediated neurotransmission and general amino acid transport.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0060012","count":5},{"id":"GO:0036233","count":4},{"id":"GO:0015824","count":4},{"id":"GO:0014064","count":4},{"id":"GO:0015820","count":4}]},{"hash":"1097205365406326478","title":"Broad organic compound catabolism and detoxification","description":"The top GO terms span degradation of diverse substrates\u2014lipids (monoacylglycerol, triglyceride, phosphatidylserine), pigments/polymers (chlorophyll, cellulose), and aromatic compounds (beta-ketoadipate pathway, 3-phenylpropionate)\u2014plus cellular oxidant detoxification. This suggests a shared theme of broad catabolic metabolism and detoxification rather than a single specific pathway, hence the label. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0052651","count":15},{"id":"GO:0006660","count":15},{"id":"GO:0019433","count":15},{"id":"GO:2000124","count":15},{"id":"GO:0098869","count":14}]},{"hash":"1151118352320678898","title":"Unknown","description":"GO terms across development, electrophysiology, sensory perception, and immune signaling show broad, multi-system roles with no single unifying function. There isn\u2019t a clear common pathway that ties all 24 proteins together, so a specific label isn\u2019t confidently supported.","confidence":"","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":7},{"id":"GO:0071502","count":6},{"id":"GO:0097623","count":6},{"id":"GO:0050968","count":6},{"id":"GO:0021750","count":6}]},{"hash":"2219304310148111590","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010586","count":7},{"id":"GO:0061158","count":6},{"id":"GO:1902187","count":6},{"id":"GO:0018032","count":6},{"id":"GO:0007014","count":6}]},{"hash":"1532572102877257758","title":"GPCR-cAMP Signaling in Vascular and Immune Tissues","description":"This cluster is driven by strong representation of adenylate cyclase\u2013activating GPCR signaling and activation of adenylate cyclase, along with regulation of blood pressure via vasopressin, suggesting a core theme around GPCR-cAMP signaling affecting vascular and immune-related processes. The presence of terms related to immune regulation (IL-1\u03b2 production, dendritic cell differentiation) and metabolic/retinal functions (electron transport chain, photoreceptor maintenance) indicates broader systemic roles but still centers on GPCR-driven signaling influencing multiple organ systems. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0045777","count":19},{"id":"GO:0007190","count":19},{"id":"GO:0045494","count":17}]},{"hash":"13700996926023874","title":"Embryonic Organogenesis and Patterning","description":"The top GO terms cluster around development of organs and tissues (left/right patterning, pancreatic endocrine development, placenta/placental regulation, heart-related EMT, and cartilage formation), pointing to a cohesive theme of embryonic organogenesis and tissue differentiation. A couple of outliers (diaphragm contraction, maltose metabolism) exist but do not shift the primary theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060707","count":8}]},{"hash":"1227268273735863873","title":"Placental and embryonic morphogenesis","description":"The top GO terms point to placental development and trophoblast differentiation, combined with left-right patterning and other embryonic morphogenesis processes (heart cushion EMT, endocrine system development, cartilage morphogenesis). This suggests a cluster of proteins involved in early development, placental formation, and organ patterning.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":12},{"id":"GO:0060972","count":10},{"id":"GO:0003323","count":10},{"id":"GO:0035270","count":10},{"id":"GO:0003198","count":10}]},{"hash":"1124604626122196219","title":"Cardiovascular development and endothelial differentiation","description":"This cluster is strongly enriched for heart and vascular biology terms: cardiac right atrium morphogenesis, venous endothelial cell differentiation, Notch signaling involved in regulation of secondary heart field cardioblast proliferation, and cell-matrix/heterophilic cell-cell adhesion, pointing to heart development and endothelial differentiation as the core theme. Additional terms touch on mechanical signaling, Hedgehog-related Smoothened pathway regulation, and vitamin D response, which can relate to developmental signaling and vascular biology; the presence of coagulation and complement activation may reflect vascular-associated processes rather than core heart morphology. Overall, the dominant signal is cardiovascular development with active adhesion and signaling components.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0003213","count":4},{"id":"GO:0060843","count":4}]},{"hash":"878575393224486005","title":"RNA splicing, editing, and processing","description":"The dominant signals point to post-transcriptional RNA maturation: alternative splicing regulation, RNA editing (A-to-I), mRNA processing and stabilization, and polyadenylation-related steps.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":3},{"id":"GO:0006382","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0001825","count":2}]},{"hash":"156876549024919102","title":"Unknown","description":"The top GO terms show a scattered mix across nervous system processes (myelination, sensory perception of sound), immune cell functions (macrophage activation, B-1a differentiation, B cell receptor signaling), and membrane organization/trafficking (eisosome assembly, transcytosis, tight junction assembly, cell adhesion). With zero edges/triangles, there's no clear shared function or pathway linking the proteins, so a single cohesive label cannot be assigned. Therefore Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0042116","count":2},{"id":"GO:0070941","count":2},{"id":"GO:0002337","count":2}]},{"hash":"1596918035603283702","title":"Enteric nervous system development and myelination","description":"The top terms center on myelination and enteric nervous system development, plus peristalsis and neural signaling pathways (Notch, ERK/MAPK). This suggests proteins in a cluster dedicated to enteric nervous system maturation and GI neural control, rather than generic detox or structural differentiation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":5},{"id":"GO:0048484","count":4},{"id":"GO:0030432","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0042493","count":4}]},{"hash":"1884443209342721150","title":"Immune signaling and cytoskeletal dynamics","description":"Proteins appear enriched for adaptive immune signaling (MyD88-dependent TLR pathway, B cell receptor signaling) and regulators of Rho/Rac cytoskeleton signaling, pointing to a theme of immune response coordination with cytoskeletal dynamics. Other terms like endothelial barrier establishment and lysosome localization fit into immune cell trafficking and vesicle processing, supporting a cohesive but broad immune-cytoskeletal function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0090557","count":4},{"id":"GO:0002755","count":4},{"id":"GO:0071560","count":3},{"id":"GO:0032418","count":3}]},{"hash":"1533982292355730032","title":"Cardiac morphogenesis and BMP/SMAD signaling","description":"The proteins in this cluster are strongly tied to heart development, with terms like ventricular septum morphogenesis, outflow tract morphogenesis, pericardium development, and mesoderm formation, plus SMAD/BMP signaling pathways. This suggests a cohesive role in cardiac morphogenesis and BMP/SMAD-mediated regulation of that process.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0010801","count":2},{"id":"GO:0010991","count":2},{"id":"GO:2000223","count":2},{"id":"GO:0060412","count":2}]},{"hash":"2020370623134074448","title":"Bone and cartilage differentiation with angiogenesis","description":"This cluster is largely defined by skeletal development terms: chondrocyte differentiation, chondroblast differentiation, osteoblast differentiation, chondrocyte/bone-related differentiation, and positive regulation of bone mineralization, along with a note of angiogenesis (endothelial cell proliferation in sprouting angiogenesis). While there are also other developmental terms (e.g., valve morphogenesis, axis specification), the dominant signal points to bone/cartilage formation and linked vascular growth, making this a coherent name for the set.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0003181","count":2},{"id":"GO:0002062","count":2}]},{"hash":"1798701499972335459","title":"Immune cell adhesion and migration","description":"The cluster is dominated by GO terms for cell adhesion and migration, including integrin-mediated signaling, heterotypic cell-cell adhesion, substrate-dependent migration, and cellular extravasation, plus T cell activation. Developmental terms (endodermal differentiation, skin development) may reflect broader tissue remodeling contexts but do not override the central theme of leukocyte adhesion and movement through tissues. Overall, a cohesive theme around immune cell adhesion and migration.","confidence":"High","size":23,"edges":241,"triangles":1540,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":6},{"id":"GO:0034113","count":6},{"id":"GO:0007229","count":6},{"id":"GO:0002291","count":6},{"id":"GO:0006929","count":6}]},{"hash":"1222632090899154442","title":"Neural and retinal development with synaptic signaling","description":"This cluster's top GO terms are dominated by neural and sensory development and synaptic function: regulation of synaptic vesicle endocytosis, regulation of neuronal synaptic plasticity, retina layer formation, and retinal cone cell development, along with calcium signaling related to release from the sarcoplasmic reticulum. Although there are terms for endocrine responses and other organ development, the strongest, coherent theme ties to neural/sensory development and synaptic activity in the retina.","confidence":"Medium","size":23,"edges":74,"triangles":48,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":16},{"id":"GO:0010842","count":16},{"id":"GO:0072221","count":12},{"id":"GO:0048168","count":12},{"id":"GO:0042403","count":10}]},{"hash":"1468941431556428341","title":"Actin-driven development in heart, vessels, and brain","description":"This cluster centers on actin cytoskeleton dynamics (actin filament bundle and lamellipodium assembly) and regulation of Rho-family GTPases, with strong links to morphogenesis in heart and neural tissues (heart development, cerebellum morphogenesis) and endothelial barrier formation, suggesting a cohesive theme of actin-mediated cell migration and tissue development. Some terms (peroxisome import, affect) may reflect broader roles or noise, but the core signal is actin-driven morphogenesis during cardiovascular and neural development.","confidence":"Medium","size":23,"edges":23,"triangles":0,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006915","count":14},{"id":"GO:0051017","count":14},{"id":"GO:0007507","count":14},{"id":"GO:0090557","count":14},{"id":"GO:0034260","count":14}]},{"hash":"2156322102461524056","title":"Steroid and lipid hormone biosynthesis","description":"The cluster is dominated by GO terms for biosynthesis of steroid hormones (testosterone, androgen, aldosterone) and lipid mediators (prostaglandins, oxylipins), with a related renal regulatory term, suggesting a cohesive theme of steroid and lipid hormone production and regulation. A couple of outlier terms exist but do not undermine the overall pattern. ","confidence":"High","size":23,"edges":60,"triangles":37,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":17},{"id":"GO:0008209","count":17},{"id":"GO:0001516","count":17},{"id":"GO:0033076","count":16},{"id":"GO:0031408","count":16}]},{"hash":"1956216274992138152","title":"HGF/MET signaling in liver development and remodeling","description":"The top terms include hepatocyte growth factor receptor signaling and liver development, with linked processes such as calcium signaling, plasminogen activation, and tissue remodeling, suggesting a MET-driven program for liver development and extracellular matrix remodeling rather than a general signaling cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014068","count":14},{"id":"GO:0048012","count":12},{"id":"GO:0014909","count":12},{"id":"GO:1902042","count":11},{"id":"GO:0001889","count":11}]},{"hash":"1785427584858036184","title":"Signal Transduction and Cytoskeletal Remodeling","description":"This cluster centers on signaling pathways (MAPK/JNK, ephrin receptor signaling) and regulators of the cytoskeleton (actin remodeling, focal adhesion), with additional hints of neuronal signaling (excitatory postsynaptic potential) and immune-related responses (defense to Gram-positive bacteria, mast cell degranulation). Although several terms are obsolete, the overall pattern points to proteins involved in translating signals into cytoskeletal and adhesion changes across cell types, rather than a single process like mitosis. Some variance (immune and neuronal terms) suggests a broad, multi-context signaling/cytoskeletal regulatory role.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":7},{"id":"GO:0000186","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0031532","count":6},{"id":"GO:0043304","count":6}]},{"hash":"1062284929422510920","title":"Neuronal signaling and sensory processing","description":"The cluster is enriched for GO terms related to nervous system function: dopaminergic synaptic transmission, visual perception and learning, sensory perception of pain, and ERK signaling\u2014all pointing to neuronal communication and plasticity. While a heart development term appears, the dominant pattern is neural signaling and sensory processing, with additional modulation of signaling pathways that influence behavior. Thus, the name captures the central theme of the cluster. ","confidence":"High","size":23,"edges":125,"triangles":201,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0007507","count":17},{"id":"GO:0001963","count":17},{"id":"GO:0071380","count":17},{"id":"GO:0010759","count":17}]},{"hash":"1630177894795537908","title":"Axon guidance and neuronal projection","description":"The top GO terms all point to neural development, focusing on axon extension, guidance of neuron projections, and localization to paranodal/juxtaparanodal regions. This includes semaphorin-plexin signaling, sympathetic neuron projection guidance, and branchiomotor/trigeminal nerve organization, indicating a cohesive theme of axon pathfinding and regional protein targeting in neurons.","confidence":"High","size":23,"edges":95,"triangles":191,"max_degree":18,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048846","count":18},{"id":"GO:0036486","count":15},{"id":"GO:0071205","count":15},{"id":"GO:0002175","count":15},{"id":"GO:0097490","count":15}]},{"hash":"2001078311849946988","title":"DNA Replication and Cell Cycle in Development","description":"The top GO terms are dominated by nuclear processes: DNA replication, mitotic cell cycle, DNA-templated transcription, and DNA repair, pointing to genome maintenance and cell cycle control. There are also signals of telomerase activity and translation regulation, plus developmental terms such as telencephalon development, cranial skeleton morphogenesis, and myoblast fusion, suggesting the proteins function in proliferative/developmental contexts. Overall, the cluster centers on genome maintenance and cell cycle, with notable developmental associations, justifying the label.","confidence":"High","size":23,"edges":7,"triangles":0,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":23},{"id":"GO:0000278","count":22},{"id":"GO:0051973","count":21},{"id":"GO:0048701","count":21},{"id":"GO:0006351","count":21}]},{"hash":"1121805544733096758","title":"Cytoskeletal remodeling and mechanotransduction signaling","description":"Cluster enriched for actin polymerization and stress fiber assembly, vesicle exocytosis regulation, and cellular responses to mechanical stimuli, with linked stress-signaling (JNK) and related pathways; together these terms point to cytoskeletal dynamics coordinating signaling and trafficking in response to mechanical cues. ","confidence":"Medium","size":23,"edges":222,"triangles":1233,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":10},{"id":"GO:0010628","count":10},{"id":"GO:2000300","count":7},{"id":"GO:0090338","count":7},{"id":"GO:0030838","count":7}]},{"hash":"4687564833708020","title":"Epithelial development and lipid metabolism","description":"Dominant GO terms point to epithelial development and differentiation (keratinocyte differentiation; lung development) and to cell signaling/remodeling (receptor clustering; positive regulation of fibroblast migration). These together suggest a module governing epithelial tissue formation and its dynamic remodeling. The cluster also includes several lipid biosynthesis terms (very long-chain fatty acid and methyl-branched fatty acid biosynthetic processes), indicating concurrent lipid metabolism that often accompanies membrane biogenesis during differentiation. A few outliers (plant-specific tropane alkaloid biosynthesis, obsolete oxidation-reduction) temper the signal, but the core theme remains epithelial development with associated lipid metabolism.","confidence":"Medium","size":23,"edges":12,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0006355","count":10},{"id":"GO:0030216","count":9},{"id":"GO:0043113","count":9},{"id":"GO:0010763","count":9}]},{"hash":"1815317640855598278","title":"Mitochondrial and peroxisomal maintenance","description":"These proteins show a pattern centered on organelle maintenance: mitochondrial functions (complex I assembly, membrane potential regulation), peroxisomal matrix protein import, and associated stress responses including oxidative stress and proteostasis. The presence of cell-cycle terms may reflect general cellular regulation rather than a focused pathway, and the nitrogen fixation term appears as an outlier. Overall, the cluster aligns with mitochondrial/peroxisomal maintenance and stress response. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009399","count":2},{"id":"GO:0032981","count":2},{"id":"GO:2001246","count":2},{"id":"GO:0034599","count":1},{"id":"GO:0006515","count":1}]},{"hash":"963863762947313343","title":"RNA splicing and translation initiation regulation","description":"Based on GO terms, the cluster centers on spliceosome-mediated mRNA processing (mRNA splicing via spliceosome) and on initiation/reinitiation of translation (translation reinitiation, formation of translation preinitiation complex, IRES-dependent initiation), with additional signals of ncRNA-mediated gene silencing. The overarching theme is coordinated RNA processing and regulation of protein synthesis, suggesting a cohesive RNA metabolism module (including viral translation aspects).","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0002188","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0075525","count":5}]},{"hash":"68559067418183976","title":"Adhesion-Mediated Migration and Survival Signaling","description":"This cluster is dominated by cell-matrix adhesion, substrate adhesion-dependent spreading, and positive regulation of fibroblast migration, with additional involvement in survival signaling (negative regulation of anoikis) and PI3K/AKT pathways, plus developmental/differentiation terms like skeletal system development and keratinocyte differentiation. The core theme centers on adhesion-guided movement and associated survival signaling, with broader developmental context.","confidence":"High","size":23,"edges":10,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007160","count":10},{"id":"GO:0010763","count":10},{"id":"GO:0034446","count":9},{"id":"GO:2000811","count":8},{"id":"GO:0001501","count":8}]},{"hash":"1810650413141165670","title":"Neuronal synapse assembly and glutamatergic signaling","description":"The top GO terms cluster around postsynaptic density assembly, NMDA and AMPA receptor clustering, and regulation of glutamatergic synaptic transmission, indicating a core role in synapse formation and function. Wnt signaling involvement and vocalization behavior further support a neural/synaptic theme, while innate immune and ubiquitination terms suggest ancillary modulation rather than the primary function. Overall, the dominant signal is synaptic assembly and glutamatergic signaling in neurons.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0050894","count":6},{"id":"GO:0097107","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0097114","count":6}]},{"hash":"2009282271605049458","title":"Developmental cytoskeletal signaling","description":"The top GO terms cluster around regulation of Rho and Ras signaling (cytoskeletal regulation), sarcomere organization, and organ development (heart, kidney), plus cell migration and neuronal/dendritic spine development. This pattern points to a theme where cytoskeletal signaling modulates development and tissue formation, including muscle structure and organogenesis, with some immune/neural terms as additional roles. Therefore a concise label capturing cytoskeletal signaling in developmental contexts best represents the cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0045214","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0016477","count":3}]},{"hash":"419293304996203942","title":"Developmental differentiation across tissues","description":"Proteins in this cluster are linked to development and differentiation across multiple tissues\u2014skeletal, muscle, nervous system (CNS and neuron projection development), and lens (lens fiber differentiation), as well as general multicellular organism development and regulation of the cell cycle. This pattern suggests a shared theme of tissue formation and maturation rather than a single pathway. Some terms like hypoxia response and spliceosome-mediated splicing point to broader cellular regulation during development, but the dominant signal is developmental differentiation across diverse tissues.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0007417","count":2},{"id":"GO:0048147","count":2}]},{"hash":"1096038552148845799","title":"Embryonic development and morphogenesis","description":"The top GO terms span both transcriptional regulation and multiple morphogenesis processes across organs and tissues (limb, neural tube, heart/vasculature, hair follicles) during embryogenesis, suggesting these proteins collectively contribute to early developmental patterning.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0060173","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0001843","count":2}]},{"hash":"1101088013703508471","title":"Deglutamylation enzymes","description":"This cluster is dominated by GO terms for deglutamylation (C-terminal, side-chain, and branching-point), suggesting proteins that remove glutamate modifications from other proteins. The other terms (blood coagulation, liver regeneration, heat response, etc.) are more diffuse and likely secondary associations, but the strongest shared function appears to be deglutamylation-related post-translational modification.","confidence":"High","size":23,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:0097421","count":6},{"id":"GO:0009408","count":6},{"id":"GO:0051260","count":5},{"id":"GO:0021702","count":5}]},{"hash":"854620426033415815","title":"Endothelial adhesion and vascular development","description":"The cluster\u2019s top GO terms point to endothelial biology and vessel formation: multiple cell-cell adhesion processes (homophilic and heterophilic), regulation of endothelial differentiation and chemotaxis, hyaluronan biosynthesis (extracellular matrix remodeling), and blood coagulation. Additional terms like response to LPS and oxidative detoxification imply inflammatory contexts affecting vessels, reinforcing a theme of endothelial cell interactions during vascular development and tissue remodeling. Confidence: High","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0007157","count":6},{"id":"GO:2001027","count":6},{"id":"GO:1900127","count":6}]},{"hash":"1283511565688887580","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around embryogenesis and organ/tissue formation, including left/right patterning, pancreatic endocrine development, placental and trophoblast differentiation, endocardial cushion EMT, and cartilage morphogenesis. A subset of terms about protein folding and ubiquitin-proteasome\u2013mediated quality control likely reflects general proteostasis supportive of development, but the dominant theme is developmental morphogenesis and differentiation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060707","count":2}]},{"hash":"1080153425800916460","title":"Developmental Signaling Across Organs","description":"This cluster centers on development-related GO terms across tissues (heart, bone, kidney) and neural features (axonogenesis, memory), with regulatory signaling (NF-kappaB and kinase activity). The combination suggests proteins coordinating developmental signaling and differentiation across organ systems rather than a single pathway, hence a label like Developmental Signaling Across Organs.","confidence":"Medium","size":23,"edges":8,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043123","count":10},{"id":"GO:0006469","count":10},{"id":"GO:0007409","count":9},{"id":"GO:0007275","count":8},{"id":"GO:0007507","count":8}]},{"hash":"370191791217591463","title":"Host Defense Modulation by Symbionts","description":"The terms cluster around host immune responses (complement activation, angiogenesis regulation) and processes indicating symbiont- or virus-driven control of host gene expression (symbiont-mediated activation/suppression, transcription regulation, DNA integration, viral release), suggesting a theme of host defense modulation by symbionts/viruses.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0039651","count":1},{"id":"GO:0000122","count":1}]},{"hash":"2089869981710664860","title":"Bacterial cell wall biosynthesis and glycosylation","description":"The top GO terms center on cell wall\u2013related processes and glycosylation, including teichoic acid biosynthesis, cellulose biosynthesis, various O-linked and N-linked protein glycosylation pathways, and UDP-glucose metabolism feeding wall polymer assembly, indicating a coherent theme of cell envelope construction and modification.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0036108","count":7},{"id":"GO:0002378","count":7},{"id":"GO:0019350","count":7},{"id":"GO:0018242","count":7},{"id":"GO:0006011","count":7}]},{"hash":"921877267644673048","title":"Diverse Metabolite Biosynthesis","description":"The top GO terms point to a range of biosynthetic processes, including fatty acid elongation and very long-chain fatty acids, retinoic acid and phylloquinone biosynthesis/related catabolic steps, polyhydroxybutyrate biosynthesis, and tropane alkaloid biosynthesis, suggesting enzymes involved in lipid, vitamin, and plant secondary metabolite production. There are also broader terms like regulation of transcription and lung development that are less pathway-specific, indicating a mix of metabolic and regulatory roles rather than a single cohesive pathway. Overall, the cluster appears to represent a broad metabolic theme centered on biosynthetic processes across diverse metabolite classes. ","confidence":"Medium","size":23,"edges":150,"triangles":491,"max_degree":19,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":19},{"id":"GO:0042619","count":14},{"id":"GO:0030324","count":13},{"id":"GO:0006355","count":13},{"id":"GO:0009710","count":13}]},{"hash":"1510847225511638359","title":"ECM remodeling and immune/coagulation signaling","description":"This cluster centers on extracellular matrix-related processes (collagen fibril organization, cartilage condensation, cell adhesion, integrin biosynthesis), complemented by immune and coagulation activities (complement activation pathways, blood coagulation, lymphangiogenesis). The combination suggests a coherent theme of connective tissue remodeling coupled with innate immune and vascular signaling, with a few more divergent terms likely incidental. ","confidence":"High","size":23,"edges":25,"triangles":3,"max_degree":19,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":4},{"id":"GO:0001867","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0001502","count":3}]},{"hash":"1959262610052734269","title":"Neural retina development and transcription regulation","description":"The top terms cluster around nervous system and retina development (including retina development in camera-type eye and photoreceptor cell maintenance) and transcriptional control (DNA-templated transcription and RNA polymerase II\u2013mediated transcription). While ubiquitin-dependent protein turnover and stress responses (e.g., glucose starvation) are present, the strongest signal ties neural/retinal development to transcriptional regulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0060765","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0045494","count":2}]},{"hash":"37030017417873662","title":"Nuclear export and cell cycle machinery","description":"This cluster shows strong representation of nuclear export (mRNA and ribosomal subunits), pre-replicative complex assembly, cell division and meiotic division, plus microtubule severing and proteasome assembly, all pointing to coordinated nuclear transport and cell-cycle machinery, with supporting notes on protein oligomerization and modification.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":2},{"id":"GO:0006267","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1270376137135263469","title":"Neural development and synaptic vesicle regulation","description":"This cluster is dominated by neural and synaptic functions: terms like retina development, synaptic vesicle clustering, and positive regulation of synaptic vesicle exocytosis point to roles in neuronal connectivity and neurotransmission. Additional terms such as regulation of respiratory gaseous exchange by nervous system process and response to glucocorticoid suggest endocrine or stress-related neural signaling, while cholesterol ester hydrolysis linked to cholesterol transport may support membrane lipid metabolism relevant to synaptic function. The presence of osteoblast development is less representative, and the core theme appears to be neural development and synaptic regulation.","confidence":"High","size":23,"edges":250,"triangles":1708,"max_degree":22,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002076","count":15},{"id":"GO:0002087","count":15},{"id":"GO:0060041","count":15},{"id":"GO:1902474","count":13},{"id":"GO:0097091","count":13}]},{"hash":"1613738964774954996","title":"Organogenesis and angiogenic signaling","description":"The top GO terms point to multiple developmental signaling pathways (Hedgehog via Smoothened, Roundabout/axon guidance), along with broad organogenesis terms (kidney, nervous system, heart, salivary gland boundary specification) and angiogenesis, plus regulation of cell migration and proliferation. This pattern suggests a cohesive module of proteins governing organ development and vascularization through diverse signaling networks. Confidence: High","confidence":"","size":23,"edges":169,"triangles":592,"max_degree":22,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007224","count":14},{"id":"GO:0035385","count":14},{"id":"GO:0050852","count":14},{"id":"GO:0001822","count":14},{"id":"GO:0007399","count":14}]},{"hash":"2091339401015685038","title":"Inflammatory signaling and cytoskeletal remodeling","description":"This cluster centers on inflammatory response, NF-kappaB signaling, and regulation of IL-1\u03b2 production, with lamellipodium assembly indicating actin cytoskeleton remodeling\u2014together pointing to immune activation and cell migration during inflammation. Additional terms like redox homeostasis and lipid metabolism fit inflammation-driven regulation, while outliers such as antibiotic biosynthesis and aging are less coherent with the main theme. Overall, the label captures the core function of inflammation signaling intertwined with cytoskeletal dynamics.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":4},{"id":"GO:0042346","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0007568","count":3},{"id":"GO:0045454","count":3}]},{"hash":"1324296127616200732","title":"Ribosome biogenesis and cell cycle","description":"The cluster is dominated by GO terms related to ribosome biogenesis and translation (cytoplasmic translation, ribosomal biogenesis, small/large subunit biogenesis, ribosomal export) alongside cell division and cell cycle processes (cell division, cell cycle, cell septum assembly). This suggests a coordinated role in ribosome assembly/production and progression through the cell cycle, with additional links to cytokinesis machinery. Some terms about stress response modulation are present but secondary to the core theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":11},{"id":"GO:0007049","count":9},{"id":"GO:0042254","count":7},{"id":"GO:1901001","count":7},{"id":"GO:0002181","count":7}]},{"hash":"2028837317623128837","title":"Inflammatory stress signaling and programmed cell death","description":"The top GO terms cluster around stress- and danger-signaling pathways, including cellular response to mechanical stimulus, necroptotic signaling, positive regulation of NF-kappaB and JNK cascades, innate immune defense, and extrinsic apoptotic signaling. Together these indicate a module focused on inflammatory signaling and cell fate decisions (apoptosis/necroptosis) in response to stress or infection. Some terms like intracellular transport or behavioral response to cocaine are less central but do not obscure the dominant theme of immune-stress signaling and programmed cell death.","confidence":"High","size":23,"edges":22,"triangles":0,"max_degree":6,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0097527","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0046330","count":4},{"id":"GO:0006886","count":4}]},{"hash":"395602537037131018","title":"Cortical Development and Neuronal Migration","description":"This cluster is dominated by terms related to brain development, cortical layer formation, and reelin-mediated signaling that guides radial glia\u2013driven neuronal migration. The inclusion of VEGF receptor signaling and angiogenesis-related terms suggests coordination between neurodevelopment and cerebral vasculature, with Ras and PI signaling components potentially modulating growth and migration pathways. The overall theme points to cortical organization and development rather than unrelated processes.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":4},{"id":"GO:0036324","count":3},{"id":"GO:0021814","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0046580","count":3}]},{"hash":"1585181051201864665","title":"Membrane repair and neural signaling proteins","description":"The cluster is driven by GO terms centered on membrane processes and neural signaling, including plasma membrane repair, regulation of synaptic vesicle exocytosis, nervous system development, and sensory perception of touch, with related axon guidance (ROBO) pathways. While some terms (e.g., T cell receptor signaling) appear immune-related or obsolete, the dominant theme ties to membrane dynamics and vesicle trafficking in neural contexts, suggesting these proteins function together in membrane signaling and maintenance.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001778","count":4},{"id":"GO:2000300","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0031384","count":4},{"id":"GO:0051092","count":3}]},{"hash":"1826000160748188549","title":"One-carbon metabolism","description":"The proteins are enriched for GO terms tied to one-carbon and methyl-group metabolism: pteridine-containing compound metabolism, choline/betaine catabolism, L-methionine salvage, the S-methylmethionine cycle, and homocysteine-related regulation. While there are broader metabolic terms (mitochondrial translation, fatty acid catabolism), they do not override the dominant methyl-group turnover theme.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042558","count":6},{"id":"GO:0042426","count":6},{"id":"GO:0006579","count":6},{"id":"GO:0071267","count":6},{"id":"GO:0033528","count":6}]},{"hash":"1748094087938342449","title":"Immune cell signaling and cytoskeleton remodeling","description":"The cluster is enriched in GO terms tied to immune signaling (B cell receptor signaling, NK cell cytotoxicity, neutrophil chemotaxis) and cytoskeletal/adhesion processes (lamellipodium assembly, integrin signaling, zonula adherens maintenance, microtubule anchoring) as well as Rho-regulated cytoskeletal dynamics. This points to a cohesive theme of immune cell activation and migration driven by cytoskeleton remodeling.","confidence":"High","size":23,"edges":24,"triangles":6,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0030032","count":4},{"id":"GO:0007229","count":4},{"id":"GO:0034453","count":4}]},{"hash":"593427453684597821","title":"Ubiquitin-regulated proteostasis and endocytosis","description":"This cluster centers on ubiquitin-dependent degradation and endocytosis: proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of ubiquitination, and both receptor-mediated and ubiquitin-dependent endocytosis are represented. Additional terms touch on Rho/GTPase signaling and cytoskeletal organization (including sarcomere processes), suggesting links between trafficking, signaling, and structural remodeling. Hypoxia response and apoptotic processes indicate stress-related remodeling often tied to proteostasis and membrane trafficking. Overall, the dominant theme is coordinated protein turnover and trafficking rather than a single metabolic pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":3},{"id":"GO:0006898","count":2},{"id":"GO:0015701","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0031397","count":2}]},{"hash":"2079301523666603572","title":"Vascular lipid metabolism and coagulation regulation","description":"The top GO terms cluster around triglyceride homeostasis and coagulation-related processes (blood coagulation, platelet aggregation regulation, vasoconstriction), suggesting a theme of lipid handling within the vasculature coupled with hemostasis. Other terms touch on extracellular matrix components and immune signaling, but the recurring signal is coordinated lipid regulation with vascular/coagulation control. Some terms like UV protection or synaptic transmission may reflect broader or multifunctional annotations, but they do not outweigh the vascular lipid/hemostasis core. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070328","count":7},{"id":"GO:0072378","count":7},{"id":"GO:0090331","count":7},{"id":"GO:0051968","count":7},{"id":"GO:0045907","count":7}]},{"hash":"756739618469105450","title":"Neuronal Development and Signaling Regulation","description":"This cluster is dominated by terms related to neural development (dendrite development, axon guidance, negative regulation of neuron apoptotic process) and signaling modulation (positive regulation of ERK cascade, regulation of Rho signaling, crude reference to insulin/PI3K signaling). While there are also angiogenesis and mast cell chemotaxis terms, the strongest theme centers on neuronal growth and the control of intracellular signaling pathways that shape neural structure and connectivity. The combination of development and signal-transduction terms suggests a cohesive theme around neural development and its regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0016358","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0038028","count":3},{"id":"GO:0035023","count":3}]},{"hash":"638509138705066361","title":"ECM Adhesion and Remodeling in Development","description":"The cluster is dominated by GO terms for extracellular matrix interactions and cell adhesion (hyaluronan metabolic process, cell-matrix adhesion, calcium-independent adhesion), plus development-related processes (embryo implantation, endodermal differentiation). Additional terms touch on ECM-associated contexts in nervous tissue (dendrite regeneration, sensory perception of sound) and protein turnover/assembly, suggesting a broader theme around ECM remodeling and adhesion supporting developmental signaling. While some terms extend beyond ECM, the strongest common thread is extracellular matrix engagement and adhesion in developmental contexts.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030212","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0007161","count":6},{"id":"GO:0031104","count":6},{"id":"GO:0007566","count":5}]},{"hash":"1830021480713298068","title":"Amino acid and polyamine biosynthesis with ribosome biogenesis","description":"The top GO terms are dominated by biosynthetic processes for amino acids and polyamines (lysine via diaminopimelate, arginine catabolism, spermidine biosynthesis, peptidoglycan biosynthesis) and the essential growth-related process of ribosome biogenesis. While there are a few additional terms (amino acid starvation response, trans-Golgi network organization) that are broader, they do not override the central theme of biosynthesis and ribosome assembly.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009089","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006697","count":1},{"id":"GO:0051607","count":1}]},{"hash":"539204331837458259","title":"Ubiquitin-mediated regulation of muscle and neural development","description":"The top GO terms show strong emphasis on ubiquitin-dependent protein catabolic processes and various ubiquitination activities (including K33-linked ubiquitination and regulation of ubiquitination), along with muscle-related development cues (skeletal muscle differentiation, sarcomere organization, skeletal muscle tissue development) and nervous system development. This suggests a theme where ubiquitin signaling controls protein turnover and developmental processes in muscle and neural tissues. The absence of network edges indicates the proteins may share these functional annotations rather than forming a tightly connected module, but the dominant signal is clearly ubiquitin-mediated regulation intertwined with muscle and neural development.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0007399","count":11},{"id":"GO:0035914","count":11},{"id":"GO:0045214","count":10},{"id":"GO:0072156","count":10}]},{"hash":"404786434829974258","title":"Ubiquitin-mediated innate immune signaling","description":"This cluster is strongly enriched for ubiquitination-related processes (ubiquitin-dependent protein catabolic process; K6- and K63-linked ubiquitination; protein autoubiquitination) alongside innate immune and antiviral defense terms, suggesting proteins that participate in ubiquitin-regulated immune signaling rather than a single degradation pathway.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0033280","count":11},{"id":"GO:0036205","count":10},{"id":"GO:1903265","count":10},{"id":"GO:0051607","count":10}]},{"hash":"1676576710657232727","title":"Thermal stress and immune-vascular signaling","description":"The cluster shows strong representation of temperature- and thermogenesis-related processes, plus several immune and vascular functions (IL-1\u03b2 regulation, dendritic cell differentiation, blood coagulation, vasopressin-regulated blood pressure, and PKA signaling). These together suggest an integrated stress response that links thermal/neuronal signaling with immune and vascular regulation. A photoreceptor maintenance term appears as a minor outlier, possibly reflecting shared signaling contexts rather than a core function. Confidence: Medium","confidence":"","size":23,"edges":7,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":20},{"id":"GO:0002024","count":20},{"id":"GO:0019233","count":20},{"id":"GO:0045494","count":18},{"id":"GO:0001992","count":18}]},{"hash":"234832177522881805","title":"Neural development and stress-immune signaling","description":"Proteins in this cluster are enriched for neural development (brain development) and signaling pathways (Wnt, NF-kappaB), coupled with cellular stress/survival processes (autophagy, apoptosis) and innate immune responses, plus microtubule organization at the centrosome. This combination points to a network coordinating neuronal development with cell fate decisions and stress-immune regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006914","count":2},{"id":"GO:0034454","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0007182","count":2}]},{"hash":"2274017783215600909","title":"Embryonic organogenesis and placental differentiation","description":"This cluster groups GO terms tied to embryonic development across several tissues\u2014placental/ trophoblast differentiation, left-right patterning, pancreatic endocrine development, and heart/cartilage morphogenesis\u2014with some connective tissue remodeling signals (cell-matrix adhesion) and occasional immune-related processes (complement activation). The common theme is broad embryonic organogenesis and tissue differentiation rather than a single pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":10},{"id":"GO:0060972","count":9},{"id":"GO:0003323","count":9},{"id":"GO:0035270","count":9},{"id":"GO:0003198","count":9}]},{"hash":"130581086906180353","title":"Developmental morphogenesis and ECM remodeling","description":"The top GO terms point to development across multiple tissues (bone, axon guidance, proximal tubule development, synapse assembly) and extracellular matrix organization (collagen fibril). Added mechanotransduction (cellular response to mechanical stimulus) and regulation of signaling pathways, suggesting a common theme of morphogenesis influenced by ECM and mechanical cues rather than a single tissue or pathway. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0006469","count":5},{"id":"GO:0016525","count":4},{"id":"GO:0030199","count":4}]},{"hash":"290868978328230166","title":"Innate immune signaling and tissue remodeling","description":"The top GO terms point strongly to innate immune pathways, including MyD88-dependent Toll-like receptor signaling and NLRP3 inflammasome assembly, along with the inflammatory response, suggesting an immune signaling core. Concurrently, collagen fibril organization and negative regulation of angiogenesis indicate extracellular matrix remodeling and vascular changes, which often accompany inflammation. Cortisol response and apoptotic processes add a stress/tissue-dynamics dimension, while a couple of development/migration terms hint at broader cellular movement contexts. Taken together, the cluster appears to reflect innate immune signaling intertwined with tissue remodeling rather than a single narrow function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0016336","count":2},{"id":"GO:0022028","count":2},{"id":"GO:0002755","count":2},{"id":"GO:0050929","count":2}]},{"hash":"1895738215175655981","title":"Developmental signaling and differentiation","description":"The Top Terms are heavily skewed toward multicellular development and tissue remodeling\u2014neural crest formation, epithelial-to-mesenchymal transition, angiogenesis, and myoblast fusion\u2014along with processes tied to cell proliferation and nuclear import. Some terms (ascospore formation, memory) appear as outliers, but the core theme points to developmental signaling and differentiation across tissues.","confidence":"Medium","size":22,"edges":210,"triangles":1204,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008284","count":22},{"id":"GO:0007613","count":22},{"id":"GO:0030437","count":22},{"id":"GO:0006607","count":22},{"id":"GO:0014029","count":22}]},{"hash":"664638845596443677","title":"Mechanosensitive signaling and NF-kB\u2013regulated apoptosis","description":"The cluster shows enrichment for cellular response to mechanical stimulus, hepatocyte and myeloid apoptosis, and regulation of NF-kappaB signaling and ubiquitination, suggesting a theme of signaling control under stress that modulates cell fate. Additional terms related to development and Hedgehog signaling (Smoothened) imply broader signaling cross-talk in these processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0097284","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0043124","count":3}]},{"hash":"1308365712530151527","title":"Neuronal axonogenesis and guidance","description":"The dominant GO terms cluster around axon development and pathfinding, including axonogenesis, axon extension, axonal fasciculation, and axon guidance, indicating a clear theme of neuronal development and neuronal connectivity. Related signaling terms (PI3K signaling, adenylate cyclase activation) support intracellular signaling in neurons, while terms like bone development or negative regulation of angiogenesis are less central and may reflect broader developmental roles or annotation noise. Overall, the cluster appears to reflect neuronal axon formation and guidance processes.","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014068","count":16},{"id":"GO:0007409","count":16},{"id":"GO:0006469","count":16},{"id":"GO:0007190","count":15},{"id":"GO:0048846","count":13}]},{"hash":"1574655242409536513","title":"Developmental signaling and stress-induced apoptosis","description":"Developmental processes (multicellular organism development, neural tube closure) overlap with stress-responsive and apoptotic pathways (TGF-beta signaling, ER-stress\u2013induced intrinsic apoptosis, G1 DNA damage checkpoint signaling, glial cell apoptotic process) and ubiquitination as a regulatory mechanism, suggesting a cluster focused on how development and cellular stress regulate cell fate. A few immune-related terms appear, but the dominant theme ties to development and apoptosis, with regulation by protein ubiquitination and complex assembly. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070208","count":5},{"id":"GO:0007584","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0071560","count":5},{"id":"GO:0072432","count":5}]},{"hash":"1361041486453780110","title":"Neural development and synaptic remodeling","description":"Most GO terms center on nervous system development and synaptic/axon remodeling, including collateral sprouting, synapse assembly, and corticospinal tract morphogenesis, with sensory perception of sound supporting a neural theme. A few terms pertain to immune signaling or angiogenesis, but they are less representative of the cluster's main function.","confidence":"Medium","size":22,"edges":13,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007605","count":4},{"id":"GO:0048671","count":4},{"id":"GO:0001525","count":3}]},{"hash":"1448137198831393513","title":"Androgen biosynthesis and metabolism","description":"The cluster is dominated by GO terms for testosterone biosynthetic process and androgen metabolic process, indicating enrichment for genes involved in steroid hormone production. Additional terms related to development (mammary gland, lung) and transcription regulation fit with downstream effects of androgens and gene expression control. A few miscellaneous terms appear but are peripheral; overall the label reflects the core function of this cluster.","confidence":"High","size":22,"edges":11,"triangles":2,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0061370","count":16},{"id":"GO:0008209","count":15},{"id":"GO:0055114","count":10},{"id":"GO:0030879","count":9},{"id":"GO:0030324","count":9}]},{"hash":"481676854636727624","title":"Vertebrate embryogenesis and tissue differentiation","description":"The cluster centers on developmental processes across multiple tissues, including neural development, somite formation, neural crest\u2013driven heart morphogenesis, and lineage specification, indicating a broad embryonic organogenesis theme; a plant stomatal development term appears as an outlier but doesn't change the overarching developmental focus.","confidence":"Medium","size":22,"edges":227,"triangles":1466,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":18},{"id":"GO:0033504","count":15},{"id":"GO:0060426","count":15},{"id":"GO:0035881","count":15},{"id":"GO:0001756","count":15}]},{"hash":"626216056980920813","title":"Lipid Biosynthesis and Related Metabolic Pathways","description":"The cluster is enriched for lipid biosynthesis and related metabolic processes (very long-chain fatty acid biosynthesis, fatty acid elongation, sphingolipid biosynthesis, retinoic acid biosynthesis), plus phylloquinone catabolic process, suggesting a cohesive theme around lipid metabolism and vitamin/secondary metabolite pathways. Some terms such as lung development and regulation of transcription are present but seem peripheral to the dominant lipid signal.","confidence":"Medium","size":22,"edges":106,"triangles":131,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":14},{"id":"GO:0030324","count":11},{"id":"GO:0006355","count":11},{"id":"GO:0009710","count":11},{"id":"GO:0042761","count":11}]},{"hash":"958480497598250423","title":"Mitochondrial respiration and neural signaling","description":"The top GO terms cluster around mitochondrial respiratory chain complex IV assembly and respirasome assembly, plus regulation of cytochrome c release, indicating a mitochondrial energy/apoptosis-related role. A subset of terms points to neural signaling and sensory pathways (estrogen response in neural tissue, acetylcholine receptor signaling, GABA receptor clustering, startle, vestibulocochlear development), suggesting these proteins may also participate in neural signaling modulation or energetically demanding neuronal processes. Overall, the common theme appears to be mitochondrial function with a neural signaling context.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":3},{"id":"GO:0097250","count":2},{"id":"GO:0090201","count":2},{"id":"GO:0071391","count":1},{"id":"GO:0051970","count":1}]},{"hash":"795120614651925442","title":"Cholesterol uptake and developmental signaling","description":"Top GO terms include receptor-mediated endocytosis involved in cholesterol transport and very-low-density lipoprotein particle clearance, alongside multiple development-related processes (ventral spinal cord development, mammary gland development, lung branching morphogenesis) and signaling (ECM signaling, Wnt pathway regulation). This suggests a cohesive theme of proteins involved in cholesterol uptake connected to developmental signaling and morphogenesis, justifying a label that combines lipid handling with developmental roles.","confidence":"Medium","size":22,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090118","count":3},{"id":"GO:0021517","count":3},{"id":"GO:0007567","count":2},{"id":"GO:0007156","count":2},{"id":"GO:1902997","count":2}]},{"hash":"1649555613190079511","title":"Actin Cytoskeleton Remodeling and Signaling","description":"This cluster's terms converge on actin dynamics: lamellipodium and filopodium assembly and general actin cytoskeleton organization, coordinated by small GTPase\u2013mediated signaling. Other terms like synaptic vesicle exocytosis and immune-related processes may reflect cytoskeleton-linked vesicle trafficking and immune cell activation, while heart development and splicing appear less central. Overall, the dominant theme is dynamic actin remodeling coupled with signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0030032","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0002344","count":2}]},{"hash":"2136837429804150322","title":"Thermosensation and myelin-related neural processes","description":"This cluster is dominated by GO terms related to pain perception and temperature sensing (sensory perception of pain; cellular and detection of temperature stimulus involved in thermoception; cellular response to temperature stimulus) along with galactosylceramide biosynthetic process, a key component of myelin lipids. Additional terms like skin development and myelination reinforce a nervous-system-centered theme, while others (visual learning, atrial repolarization) are broader annotations that may appear in mixed clusters. Overall, the common thread points to neural thermosensory signaling and myelin-associated lipid biosynthesis. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0008542","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0050960","count":3}]},{"hash":"459489881019981923","title":"Membrane Transporters for Small Molecules and Ions","description":"This cluster is characterized by a broad set of transmembrane transport GO terms across diverse substrates, including sialic acid, nitrite/nitrate, xenobiotics, vitamins, and sodium ions, plus vesicular neurotransmitter loading. The common thread is membrane transport capability across substrates rather than a single substrate, indicating a group of transporter proteins with varied specificities.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":5},{"id":"GO:0015707","count":4},{"id":"GO:0006855","count":4},{"id":"GO:1900754","count":4},{"id":"GO:0015706","count":4}]},{"hash":"999688222335066195","title":"Telomere maintenance and mitotic regulation","description":"The cluster shows multiple GO terms centered on telomere maintenance (positive regulation via telomerase, telomere length regulation) and mitotic control (spindle assembly, negative regulation of CDK activity), pointing to roles in genome stability during cell division. Some other terms (membrane localization, SNARE regulation) are broader regulatory themes but do not undermine the core connection to cell cycle and telomere processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0051225","count":4},{"id":"GO:0032212","count":4},{"id":"GO:0045736","count":4},{"id":"GO:1904743","count":4}]},{"hash":"1694451577975384812","title":"Unknown","description":"The top GO terms are a mix of nucleotide metabolism (allantoin biosynthesis, urate catabolic process, purine nucleobase metabolism) and unrelated processes (cell growth signaling, spindle checkpoint signaling, mRNA splicing, neural crest cell migration). With no edges or cohesive functional theme tying the proteins together, there isn\u2019t a clear shared function to label; thus Unknown with None confidence. ","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019428","count":1},{"id":"GO:0019628","count":1},{"id":"GO:0001560","count":1},{"id":"GO:0006144","count":1},{"id":"GO:0032516","count":1}]},{"hash":"1791721150025244469","title":"Vascular and nephron morphogenesis","description":"The enriched GO terms cluster around vascular development (angiogenesis, VEGF signaling, lymph vessel morphogenesis) and metanephric tubule morphogenesis, suggesting a shared developmental program governing vascular and kidney morphogenesis, with some neural and immune process terms appearing as ancillary associations.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0016525","count":3},{"id":"GO:0036303","count":3},{"id":"GO:0072237","count":3},{"id":"GO:0051965","count":3}]},{"hash":"1094673719003578597","title":"Mitochondrial translation and ATP synthase assembly","description":"This cluster centers on mitochondrial protein processes: translation (GO:0006412), import into the mitochondrial matrix (GO:0030150), and assembly of the proton-transporting ATP synthase complex (GO:0033615). These core terms point to mitochondrial protein synthesis and assembly pathways, suggesting a theme of mitochondrial protein homeostasis; other terms (lipid metabolism, signaling responses) appear less central but may reflect broader cellular context.","confidence":"Medium","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0033615","count":2},{"id":"GO:0008203","count":2},{"id":"GO:0050821","count":2},{"id":"GO:0030150","count":2}]},{"hash":"46453526303254165","title":"Chromatin organization and histone modification","description":"The cluster centers on chromatin-related processes: heterochromatin organization, nucleosome assembly/ positioning, and histone methylation marks (H3-K4 and H3-K27), suggesting a cohesive set of proteins involved in establishing and maintaining compact chromatin and transcriptional regulation.","confidence":"High","size":22,"edges":114,"triangles":288,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":8},{"id":"GO:0098532","count":8},{"id":"GO:0070828","count":7},{"id":"GO:0097298","count":7},{"id":"GO:0071169","count":7}]},{"hash":"2057079306416768120","title":"Cell Division and DNA Replication","description":"This cluster centers on core cell-cycle processes: DNA replication, mitotic chromosome alignment, and sister chromatid separation, along with the broader cell division term. Supporting processes like mRNA export and ubiquitin-dependent proteolysis are also relevant to division, while the lipopolysaccharide response appears incidental. Overall, the strongest shared function is cell division/DNA replication machinery.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007080","count":3},{"id":"GO:0001824","count":3}]},{"hash":"1066193272436674076","title":"Neuronal receptor trafficking and synaptic plasticity","description":"GO terms show receptor internalization and clustering, glutamatergic and GABAergic synaptic transmission, long-term synaptic depression, visual learning, and ethanol-related behavioral responses, all pointing to a module of synaptic signaling and activity-dependent plasticity. Ion transport by potassium and sodium channels aligns with neuronal excitability changes underpinning these functions. Acknowledging a couple terms related to blood vessel maturation, the core signal remains neural synaptic dynamics. ","confidence":"High","size":22,"edges":20,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":4},{"id":"GO:0043113","count":4},{"id":"GO:0035249","count":3},{"id":"GO:0048149","count":3},{"id":"GO:0060292","count":3}]},{"hash":"1413732399570863277","title":"Neural signaling and ion transport","description":"This cluster is dominated by GO terms related to auditory perception, neural communication (GABA signaling, excitatory postsynaptic potential), conditioned behaviors, and ion transport across membranes (Na+, K+ channels), pointing to a cohesive theme of neuronal signaling and ion-channel activity. An outlier term about photosystem II repair may be a misannotation, but the neural-signaling theme remains evident.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0010206","count":2},{"id":"GO:0018279","count":2},{"id":"GO:0060013","count":2},{"id":"GO:0001661","count":2}]},{"hash":"1398203143834310070","title":"Embryonic development and organ morphogenesis","description":"The top terms cluster around embryonic patterning (left/right axis formation), multiple organ development processes (pancreas/endocrine system, placenta), and tissue morphogenesis such as cartilage and palate formation, plus EMT in heart development. While there are a few more general or regulatory terms (splicing, vitamin D regulation), the dominant signal is developmental patterning and organogenesis.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":12},{"id":"GO:0003323","count":12},{"id":"GO:0035270","count":12},{"id":"GO:0003198","count":12},{"id":"GO:0060707","count":12}]},{"hash":"896629793491164755","title":"ECM remodeling and connective tissue development","description":"This cluster centers on extracellular matrix\u2013related processes: collagen catabolic and collagen-activated signaling, integrin biosynthesis, skin morphogenesis, cartilage and endochondral bone development, and cuticle development. These terms point to connective tissue formation and ECM remodeling as the core theme, with some ancillary immune-related terms (complement activation) and regulatory pathways, but the dominant signal is ECM and tissue development. ","confidence":"Medium","size":22,"edges":86,"triangles":130,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0030574","count":3},{"id":"GO:2000860","count":2},{"id":"GO:0045112","count":2}]},{"hash":"1472212435597919463","title":"Multisubstrate membrane transporters","description":"These proteins are enriched for transmembrane transport terms across a range of substrates (xenobiotics, vitamins, ions, sugars) and vesicular neurotransmitter loading, suggesting a cluster of diverse membrane transporter proteins. ","confidence":"High","size":22,"edges":31,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":22},{"id":"GO:0035461","count":22},{"id":"GO:0042891","count":21},{"id":"GO:0071805","count":18},{"id":"GO:0042908","count":18}]},{"hash":"408379039674908621","title":"Muscle, adipose, and vascular development","description":"The cluster\u2019s top GO terms are dominated by skeletal muscle fiber development, muscle tissue regeneration, fat cell differentiation, and endothelial cell development with vasodilation, pointing to a shared theme of mesoderm-derived tissue differentiation in muscle, fat, and vasculature. Sensory and xenobiotic-related terms appear as secondary associations but do not define the core function. Confidence: Medium","confidence":"","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0042220","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0009650","count":2}]},{"hash":"1607540637898637830","title":"Neuronal synapse assembly and neurotransmission","description":"The cluster is enriched with terms tied to synaptic architecture and signaling, including synaptic vesicle clustering, neurexin clustering in presynaptic membranes, regulation of receptor recycling, and modulation of cholinergic synaptic transmission. These collectively point to a cohesive function in synapse formation and neuronal communication. While terms like retina development and osteoblast development appear, the dominant theme remains synaptic organization and neurotransmission in neurons.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0002076","count":16},{"id":"GO:0002087","count":16},{"id":"GO:0060041","count":16},{"id":"GO:0097091","count":14},{"id":"GO:0051384","count":14}]},{"hash":"1516154015436120688","title":"NF-\u03baB\u2013driven inflammatory and T-cell signaling","description":"The top GO terms point to immune activation and inflammatory pathways, including NF-\u03baB and JNK cascades, T cell receptor signaling, IL-1/IL-17 signaling, and immunoglobulin-mediated responses. While a few terms like brain development or mechanical stimulus response appear, the dominant theme is NF-\u03baB\u2013related inflammatory and adaptive immune signaling, suggesting these proteins cluster around immune activation. ","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0046330","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0016064","count":4}]},{"hash":"2094115142823339251","title":"Innate immune response and wound healing","description":"This cluster is dominated by GO terms for innate immunity and defense against pathogens (e.g., innate immune response, defense response to virus/bacterium) and tissue repair processes (wound healing, collagen fibril organization). Additional terms like cellular response to mechanical stimulus suggest ECM remodeling during repair. Taken together, the proteins appear to function as a module linking immune defense with tissue repair, justifying the label. ","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0045089","count":2},{"id":"GO:0042060","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051607","count":2}]},{"hash":"849947492335953540","title":"Immune receptor signaling and cell adhesion cluster","description":"The cluster is dominated by immune-related GO terms: innate and adaptive immune responses, B cell receptor signaling, Fc-epsilon receptor signaling, and positive regulation of IL-2 production, indicating a coherent theme around immune activation and signaling. Also, regulation of Rho protein signaling aligns with cytoskeletal changes typical of leukocyte activation, and both homophilic and heterophilic cell\u2013cell adhesion terms fit leukocyte interactions. A few terms (heart development, sodium ion transport) appear less connected and may reflect broad annotations or incidental associations. Overall, the core theme points to immune signaling with supporting adhesion and cytoskeletal dynamics.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0007156","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0002250","count":4}]},{"hash":"2079028167449652120","title":"Notch-regulated development and patterning","description":"The top terms center on Notch signaling regulation (positive and negative) and development across multiple tissues (follicle, intestinal epithelium, hypochord, compartments, meiosis), plus pattern specification, suggesting the cluster represents proteins involved in signaling-driven development and tissue patterning rather than a single tissue-specific function.","confidence":"Medium","size":22,"edges":75,"triangles":153,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":8},{"id":"GO:0055016","count":6},{"id":"GO:1902367","count":6},{"id":"GO:0045747","count":6},{"id":"GO:0032092","count":6}]},{"hash":"2170284964391812674","title":"Lipid metabolism and membrane trafficking","description":"The cluster shows several lipid-centric processes (sphingolipid metabolism, unsaturated fatty acid biosynthesis, ergosterol biosynthesis regulation) and vesicle trafficking (COPI-coated vesicle budding), suggesting a membrane biogenesis/homeostasis program. While there are additional terms related to metabolism and organelle dynamics (NO production, nitrate assimilation, mitochondrial inheritance), the strongest shared theme among the top terms is lipid metabolism coupled with membrane trafficking. High","confidence":"","size":22,"edges":40,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006675","count":3},{"id":"GO:0006809","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0006636","count":3},{"id":"GO:0032443","count":3}]},{"hash":"231407839010537585","title":"Auditory perception and GABAergic signaling","description":"The cluster centers on auditory sensory functions (sound detection and perception) and neural signaling, with items like potassium and calcium ion transport underpinning excitability, and GABAergic signaling balancing synaptic activity. Behavioral themes such as startle, locomotion, and conditioned responses likely reflect neural circuits mediating hearing-related behaviors and overall activity, supporting a cohesive auditory-neuronal signaling theme.","confidence":"High","size":22,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":19},{"id":"GO:0050910","count":18},{"id":"GO:0001661","count":18},{"id":"GO:0001964","count":18},{"id":"GO:0007605","count":18}]},{"hash":"1604531174445939415","title":"Ubiquitin-Dependent Proteolysis in Muscle Development","description":"The top GO term is ubiquitin-dependent protein catabolic process, with strong representation of muscle-related terms (sarcomere organization, skeletal muscle cell differentiation, skeletal muscle tissue development). This points to a cluster of proteins involved in ubiquitin-mediated protein turnover that influences muscle development and structure. Additional terms about ubiquitination regulation (negative regulation of protein ubiquitination; K33-linked ubiquitination) support a central role for the ubiquitin system, while other development terms (distal tubule morphogenesis, renal sodium absorption, nervous system development) may reflect broader developmental roles of ubiquitination rather than changing the core theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":21},{"id":"GO:0045214","count":14},{"id":"GO:0072156","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0035914","count":14}]},{"hash":"676827631011338185","title":"Thermoregulation, pain, and immune-vascular signaling","description":"This cluster centers on temperature response and thermogenesis, pain perception, and several immune/vascular-related processes (IL-1\u03b2 regulation, dendritic cell differentiation, vasopressin-regulated blood pressure, coagulation, and PKA signaling), suggesting a cohesive theme of systemic stress responses linking thermoregulation with immune and vascular control. The photoreceptor maintenance term is less central but may reflect broader sensory/neuronal maintenance roles.","confidence":"Medium","size":22,"edges":42,"triangles":4,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0019233","count":16},{"id":"GO:0045494","count":14},{"id":"GO:0001992","count":14}]},{"hash":"184742205742861356","title":"Neural signaling and ion transport","description":"The proteins cluster around neuronal communication: startle response, locomotory behavior, GABA signaling, EPSP, and regulation of nerve impulse, plus ion transport across membranes (calcium, sodium, potassium). The circadian sleep/wake regulation term further ties these proteins to neural circuits governing activity and rest, suggesting the core function is synaptic signaling and ion-channel\u2013mediated excitability that underpins behavior. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":19},{"id":"GO:0098703","count":19},{"id":"GO:0045188","count":19},{"id":"GO:0071805","count":18},{"id":"GO:0035725","count":18}]},{"hash":"1201332918435804554","title":"Signaling and vascular-immune regulation","description":"The GO terms point to GPCR-activated signaling, vascular regulation (vasopressin, blood pressure), Rho signaling, and immune modulation (IL-1\u03b2 production, dendritic cell differentiation), plus cell proliferation. There are additional terms related to energy metabolism and sensory maintenance, suggesting some breadth across tissues. Overall, the cluster appears centered on signaling pathways governing cardiovascular and immune functions, with some noise from unrelated processes; hence the label reflects the dominant theme but with moderate specificity.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":22},{"id":"GO:0022900","count":22},{"id":"GO:0045777","count":22},{"id":"GO:0035025","count":22},{"id":"GO:0045494","count":20}]},{"hash":"169745145661324746","title":"Regulatory signaling and transcription processes","description":"These proteins show enrichment for regulatory roles across multiple cellular functions rather than a single pathway. Top GO terms point to regulation of kinase activity (including CDKs), transcription (DNA-templated), regulation of synaptic plasticity, spindle assembly, telomere maintenance, and endocytosis, with several entries framed as negative or positive regulation. This pattern suggests a cluster of broadly acting regulators of signaling, gene expression, and cell-cycle-related processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006469","count":10},{"id":"GO:0006351","count":8},{"id":"GO:0048549","count":8},{"id":"GO:0050968","count":7},{"id":"GO:1900383","count":7}]},{"hash":"1666006259237256894","title":"Innate immune apoptosis and ubiquitination","description":"This cluster is dominated by terms for apoptosis (GO:0006915) and pyroptosis, along with protein ubiquitination (GO:0016567) and the broader innate immune response (GO:0045087). The presence of tags for detection of bacterial components (muramyl dipeptide, bacterium) and TNF signaling regulation (positive TNF production, NF-kappaB regulation) indicates a coherent theme around innate immune sensing and inflammatory cell death processes, with ubiquitination playing a regulatory role. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006915","count":17},{"id":"GO:0016567","count":17},{"id":"GO:0070269","count":17},{"id":"GO:0045087","count":17},{"id":"GO:1990001","count":17}]},{"hash":"899018299965551326","title":"Complement Activation and Blood Coagulation","description":"The top GO terms center on the complement system (lectin and classical pathways) and coagulation cascades (Factor XII activation, plasminogen activation, fibrinolysis), with related defense against Gram-positive bacteria and tissue remodeling/angiogenesis. This indicates a cohesive theme of proteins involved in innate immune defense linked to coagulation and vascular remodeling, justifying a label that reflects both pathways.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0030574","count":6},{"id":"GO:0006958","count":5},{"id":"GO:0030194","count":5},{"id":"GO:0007596","count":4}]},{"hash":"1934397924330144035","title":"Thermoception and Pain with Developmental Roles","description":"The cluster shows strong ties to temperature detection and pain perception (thermoception and nociception), with additional GO terms for skin and bone development and vestibular nucleus development, implying a functional group linking sensory perception to developmental processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050960","count":7},{"id":"GO:0043588","count":7},{"id":"GO:0071502","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0002024","count":5}]},{"hash":"306028442349422894","title":"Placental development and ECM remodeling","description":"The dominant GO terms point to placental and trophoblast development, including trophoblast giant cell differentiation and endocrine system development, suggesting a placental/embryonic development theme.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":12},{"id":"GO:0060972","count":11},{"id":"GO:0003323","count":11},{"id":"GO:0035270","count":11},{"id":"GO:0003198","count":11}]},{"hash":"243669565894077786","title":"Organogenesis and developmental signaling","description":"This cluster centers on developmental processes across multiple tissues (nervous system, heart, skeletal system) and multicellular organism development, with accompanying growth factor signaling pathways (FGFR-mediated, erythropoietin signaling) and modulation of STAT phosphorylation. The shared theme is signaling events that drive organ development and tissue differentiation, suggesting proteins involved in organogenesis and developmental regulation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0038162","count":2},{"id":"GO:0007275","count":2},{"id":"GO:1902178","count":2},{"id":"GO:0001501","count":2}]},{"hash":"988124378346244525","title":"Signaling and Cytoskeletal Remodeling","description":"The terms point to signaling pathways (EGFR, T cell receptor), cytoskeletal dynamics (actin filament bundles, cell migration), and differentiation/development (Purkinje cell differentiation), with additional associations to stress responses. This suggests a coherent theme of signaling coordinating cytoskeletal remodeling and morphogenesis, even though the terms span multiple contexts.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0043403","count":2}]},{"hash":"1550667595979575275","title":"Cardiovascular development and function","description":"Top GO terms indicate heart morphogenesis (right atrium), venous endothelial differentiation, Notch signaling in heart-field cardioblasts, calcium signaling, and processes like cell-matrix adhesion and vasoconstriction, plus coagulation and vitamin D response. This constellation points to a cardiovascular development and function theme rather than unrelated processes, justifying a concise label that captures both development and vascular activity. My confidence is High.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0003213","count":4},{"id":"GO:0060843","count":4},{"id":"GO:0003270","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0033280","count":4}]},{"hash":"963849485005970170","title":"Thermal Stress Signaling and Calcium-MAPK Pathways","description":"The cluster combines terms for temperature response and thermogenesis with calcium release, ERK1/2 signaling, and sensory processes, all pointing to a network of stress- and signal-transduction pathways that regulate vascular tone, bone remodeling, and immune responses under thermal or systemic stress.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0046849","count":5},{"id":"GO:0006955","count":5}]},{"hash":"1326195939922521391","title":"Developmental signaling and tissue remodeling","description":"This cluster shows involvement in organ development (pancreatic cell development, multicellular organism development), angiogenesis, extracellular matrix organization (collagen fibril), and key signaling pathways (Wnt, ERK, and STAT). The inclusion of immune-related terms suggests tissue interactions during development as well. Together, these terms point to coordinated developmental signaling and ECM-mediated remodeling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0070374","count":3}]},{"hash":"1456538420915368455","title":"Immune Signaling and Development","description":"The top GO terms point to immune-related signaling (positive regulation of ERK1/2 cascade, B cell receptor signaling, complement activation, NF-kappaB-related activity) as well as developmental processes (endocrine system development, cartilage morphogenesis, epithelial-to-mesenchymal transition in heart development). This mix suggests the cluster features broad signaling roles spanning immune responses and developmental pathways rather than a single cohesive function. Confidence: Medium.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0001867","count":2},{"id":"GO:0031532","count":2}]},{"hash":"903902330261310","title":"Neural and muscle development with actin dynamics","description":"Top GO terms indicate coordinated neural (telencephalon development, bipolar cell polarity) and muscle (myoblast fusion) development, coupled with actin cytoskeleton remodeling (actin cytoskeleton reorganization, actin filament binding) and regulation of protein synthesis and signaling (translation, JUN kinase activity). This suggests a cluster of proteins involved in developmental programs for neural and muscle tissues that rely on actin-driven morphogenesis and controlled translation. ","confidence":"High","size":21,"edges":173,"triangles":786,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":21},{"id":"GO:0007520","count":21},{"id":"GO:0021537","count":21},{"id":"GO:0045727","count":21},{"id":"GO:0031532","count":21}]},{"hash":"807743469020454654","title":"Chromatin acetylation and metabolism","description":"The top GO terms cluster around acetylation-related processes: peptidyl-lysine N6-acetylation and spermine acetylation, plus subtelomeric heterochromatin formation, which points to chromatin modification. Supporting metabolism terms involve N-acetylglucosamine/glucosamine (acetylated sugars), suggesting a link to acetyl-CoA\u2013dependent pathways. A few terms reference development (leaf formation, angiogenesis), but the strongest signal is acetylation-driven chromatin regulation, with metabolic connections.  ","confidence":"Medium","size":21,"edges":117,"triangles":281,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006044","count":15},{"id":"GO:0001525","count":15},{"id":"GO:0006348","count":15},{"id":"GO:2000025","count":15},{"id":"GO:0046208","count":15}]},{"hash":"352761636925303670","title":"ECM Remodeling and Inflammation","description":"The cluster is dominated by GO terms linking extracellular matrix organization (fibronectin and collagen fibrils) with inflammatory processes (acute inflammatory response, cytokine production) and developmental pathways (somite and chondrocyte differentiation), suggesting proteins involved in ECM remodeling that co-occur with inflammatory signaling during development.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1905590","count":19},{"id":"GO:0030199","count":19},{"id":"GO:0010744","count":19},{"id":"GO:0018277","count":19},{"id":"GO:0034381","count":19}]},{"hash":"39794164631944318","title":"Rho GTPase\u2013mediated cytoskeleton remodeling and migration","description":"The cluster is dominated by small GTPase signaling and Rho-family regulation, with strong representation of actin-based protrusions (filopodium/lamellipodium assembly), cell spreading/adhesion, polarity maintenance, and endocytosis. This points to a cohesive module governing cytoskeletal dynamics, cell movement, and epithelial organization rather than a single enzyme function.","confidence":"High","size":21,"edges":17,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007264","count":11},{"id":"GO:1900026","count":11},{"id":"GO:0046847","count":10},{"id":"GO:0035023","count":10},{"id":"GO:0030032","count":9}]},{"hash":"289413929629535562","title":"Neurovascular development and angiogenesis","description":"The top GO terms point to vascular and placental morphogenesis (coronary artery morphogenesis, placental branching morphogenesis), endothelial chemotaxis, and plasminogen activation, all aligning with angiogenesis and vessel remodeling. At the same time, neural-related terms (axon extension/guidance, regulation of synaptic plasticity, kainate receptor activity) indicate concurrent neural development. This combination suggests a coordinated neurovascular development theme rather than a single isolated process, hence the chosen label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":16},{"id":"GO:0007171","count":12},{"id":"GO:0045766","count":11},{"id":"GO:0060672","count":9},{"id":"GO:0048168","count":9}]},{"hash":"281259146176518940","title":"Wnt/Hippo/TGF-\u03b2 Signaling in Keratinocyte Differentiation","description":"This cluster centers on signaling pathways that balance cell growth, differentiation, and apoptosis, notably Wnt (canonical), Hippo, and TGF-\u03b2 signaling, with keratinocyte differentiation as a key readout. The combination of terms related to TGF-\u03b2 regulation, Wnt activation, Hippo pathway, and transcriptional control suggests proteins that coordinate epidermal cell fate decisions and proliferation, consistent with a differentiation/growth control module.","confidence":"Medium","size":21,"edges":163,"triangles":631,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030512","count":10},{"id":"GO:0090263","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0030216","count":9},{"id":"GO:0060044","count":9}]},{"hash":"525501048348184418","title":"Cerebellar development and glial differentiation with immune signaling","description":"This cluster is dominated by neural development terms pointing to the cerebellum, including cerebellar cortex formation and Bergmann glial cell differentiation, as well as axon regeneration. At the same time, it shows strong immune-related terms (innate immune response, defense against Gram-positive bacteria, and T cell receptor signaling), suggesting a link between cerebellar development and immune signaling processes. While there are some cell-cycle/kinetochore terms present, the prominent theme appears to be cerebellar neurodevelopment with immune signaling interactions.","confidence":"Medium","size":21,"edges":190,"triangles":1015,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045736","count":17},{"id":"GO:0034501","count":17},{"id":"GO:0045087","count":15},{"id":"GO:0050830","count":15},{"id":"GO:0048679","count":14}]},{"hash":"91823320679476527","title":"Immune signaling with apoptosis regulation and actin remodeling","description":"This cluster is enriched for immune-related signaling terms (erythropoietin signaling, IL-12 response, mast cell regulation) and processes tied to cell survival and programmed cell death, along with actin cytoskeleton reorganization. The common theme appears to be signaling pathways that govern immune responses and cell fate, linked to cytoskeletal dynamics, rather than a single structural or developmental function. Confidence: Medium","confidence":"","size":21,"edges":82,"triangles":103,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":21},{"id":"GO:0031532","count":21},{"id":"GO:1904531","count":21},{"id":"GO:2000811","count":21},{"id":"GO:0002651","count":21}]},{"hash":"1620181105206376","title":"RNA processing and developmental cell-cycle regulation","description":"The cluster centers on RNA processing (mRNA splicing and polyadenylation) and development-related control of proliferation/differentiation, with additional signals linked to epidermal growth factor response, mechanical stimuli, and apoptotic pathways, suggesting a link between RNA maturation and cell-cycle/developmental regulation.","confidence":"Medium","size":21,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0045292","count":3},{"id":"GO:1900363","count":3},{"id":"GO:0071260","count":2},{"id":"GO:0071364","count":2}]},{"hash":"1870573549568526353","title":"Mitochondrial dynamics and cell cycle cluster","description":"The top GO terms center on cell division and cell cycle, with mitochondrial distribution/inheritance, ribosomal subunit export, and apoptotic processes, suggesting a core theme of coordinating organelle dynamics with cell-cycle progression. Additional terms like endocytic recycling and GABAergic transmission appear as broader, supporting processes, but the central tie is mitochondria-related dynamics linked to division. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0007049","count":8},{"id":"GO:0048312","count":7},{"id":"GO:0000055","count":7},{"id":"GO:0032456","count":5}]},{"hash":"249766067974520144","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0071031","count":2}]},{"hash":"2118874017662907326","title":"RNA splicing and mRNA processing","description":"The strongest signals in this cluster are RNA-processing related: spliceosomal complex disassembly, regulation of alternative splicing via the spliceosome, and 7-methylguanosine mRNA capping. These terms point to RNA maturation and splicing as a unifying theme, suggesting the proteins may function together in RNA processing rather than a single signaling pathway. Some developmental terms (skeletal development, planar polarity) appear among the annotations, which could reflect multifunctionality or annotation noise, but the clearest shared function appears to be RNA splicing/processing.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0035234","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0001736","count":2},{"id":"GO:0000390","count":1}]},{"hash":"751782174155618491","title":"Innate Immune Activation and NF-kB Signaling","description":"This cluster combines innate immune response terms (inflammatory response, defense against Gram-positive bacteria, innate immune response, type II interferon production) with NF-kB pathway activity (I-kappaB phosphorylation) and cytoskeletal/adhesion dynamics (filopodium assembly, cellular response to mechanical stimulus, platelet activation), indicating coordinated signaling and cell movement during immune activation.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0071260","count":4}]},{"hash":"2292251033346141264","title":"Developmental Signaling and Axis Patterning","description":"The dominant GO terms point to developmental signaling pathways (Notch, Wnt), axis specification (left/right, dorsal/ventral), and neural tissue development (retina, synapse assembly), suggesting a cluster centered on embryonic patterning and neural development. Some terms like memory and coagulation are outliers but do not override the core theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0051965","count":7},{"id":"GO:2001027","count":7},{"id":"GO:0044332","count":6},{"id":"GO:0045746","count":6}]},{"hash":"1575164973424977305","title":"Prostaglandin biosynthesis and COX signaling","description":"This cluster is strongly enriched for prostaglandin biosynthesis and cyclooxygenase pathway terms, with additional signs of hormonal (estradiol) responsiveness and impacts on vascular cell behaviors (endothelial/smooth muscle chemotaxis). Redox/detoxification terms tie in to oxidative processes often linked to prostaglandin metabolism, while some developmental terms (Notch regulation, hair orientation) may reflect broader remodeling contexts. Overall, the themes cluster around prostaglandin production/signaling modulated by hormones and redox state.","confidence":"Medium","size":21,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0098869","count":13},{"id":"GO:0032355","count":11},{"id":"GO:0071672","count":11},{"id":"GO:0019371","count":11},{"id":"GO:0051965","count":11}]},{"hash":"2160769083372890010","title":"RNA Splicing and Translation Regulation","description":"The proteins cluster around post-transcriptional control: spliceosome-mediated regulation of mRNA splicing, regulation of mRNA stability and polyadenylation, mRNA stabilization, translation initiation/reinitiation, and ncRNA-mediated gene silencing. These together point to a cohesive role in processing and regulating transcripts after transcription, affecting both splicing choices and translation efficiency.","confidence":"High","size":21,"edges":28,"triangles":2,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":11},{"id":"GO:0048026","count":10},{"id":"GO:0010610","count":10},{"id":"GO:0002188","count":9},{"id":"GO:0001731","count":9}]},{"hash":"1508011585617664810","title":"Neuronal morphogenesis and signaling","description":"The cluster is enriched for neural development and signaling terms (regulation of branching morphogenesis of a nerve, Wnt signalosome assembly, Roundabout signaling pathway), along with related intracellular trafficking and mechanotransduction responses, suggesting a cohesive theme around neural morphogenesis and signaling pathways.","confidence":"Medium","size":21,"edges":6,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000172","count":8},{"id":"GO:0071260","count":8},{"id":"GO:1905279","count":8},{"id":"GO:1905289","count":8},{"id":"GO:0071287","count":8}]},{"hash":"466560220303054531","title":"Embryonic Development and Tissue Morphogenesis","description":"The GO terms point to broad developmental and morphogenetic processes, including placental and endocrine system development, left/right patterning, EMT in heart/placental contexts, cartilage morphogenesis, and extracellular matrix remodeling, with accompanying signaling. This suggests a cluster of proteins involved in early development and tissue formation rather than a single mature function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3}]},{"hash":"1204199960616143970","title":"Multisystem development and differentiation","description":"The top GO terms center on development and differentiation across diverse tissues (melanocytes, cardiac neural crest derivatives, vestibular/inner ear, pancreatic and stomach neuroendocrine lineages, osteoblasts, etc.) and general transcription by RNA polymerase II. This points to a broad developmental program rather than a single pathway or tissue-specific function, spanning multiple organ systems.","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":17},{"id":"GO:0030318","count":16},{"id":"GO:0003253","count":16},{"id":"GO:0021750","count":16},{"id":"GO:0003062","count":16}]},{"hash":"937977887428792041","title":"ECM Remodeling and Skeletal Development","description":"The cluster centers on extracellular matrix processes, with terms for extracellular matrix disassembly, collagen fibril organization, and bone/hard palate development, indicating roles in ECM remodeling during skeletal tissue formation. A few terms touch innate immunity, but the strongest signal is ECM organization/remodeling linked to skeletal development, so the label remains representative.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060335","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0014911","count":2},{"id":"GO:0060022","count":2}]},{"hash":"1952965758671387039","title":"Innate Immune NF-kB Regulation","description":"The cluster centers on innate immunity and antiviral defense, with multiple terms pointing to NF-kappaB signaling regulation (canonical and non-canonical), ubiquitin-mediated protein turnover, and transcriptional control, all of which commonly coordinate immune responses and antigen presentation (MHC I). A few non-immune terms appear but do not override the dominant immune signaling theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043124","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0045345","count":2},{"id":"GO:0042787","count":2}]},{"hash":"1829596300519938010","title":"Muscle and neural synapse development","description":"This cluster combines terms for muscle development (sarcomere organization, myoblast fusion) with neural synaptic formation and transmission (synapse assembly, glutamatergic transmission, long-term potentiation, calcium signaling). While also touching on developmentally related processes like neural crest cell migration and angiogenesis regulation, the shared theme appears to be coordinated muscle and neural synapse development and signaling. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":4},{"id":"GO:0007520","count":2},{"id":"GO:0007416","count":2},{"id":"GO:0071277","count":2},{"id":"GO:0060291","count":2}]},{"hash":"1628802615220989139","title":"ER stress and proteostasis responses","description":"Most terms center on protein folding, ER stress, unfolded protein response, and translation adjustment in stress \u2014 all aspects of proteostasis. Additional terms like oxidative stress response and signaling to immune/stress pathways fit under general cellular stress signaling. Thus the label ER stress and proteostasis responses captures the dominant theme.","confidence":"High","size":21,"edges":178,"triangles":855,"max_degree":20,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0043278","count":10},{"id":"GO:0071357","count":9},{"id":"GO:0010288","count":9},{"id":"GO:0070301","count":9},{"id":"GO:0036494","count":9}]},{"hash":"434954230127955143","title":"Cell cycle and mitochondrial distribution","description":"The cluster is dominated by cell division and cell cycle terms (cell division, cell cycle, mitotic cell cycle), with strong signals for intracellular mitochondrial distribution and mitochondrial inheritance, plus ribosomal subunit export, which ties to growth and division. Additional terms cover endocytic recycling, GABAergic signaling, Wnt signaling, and defense responses, suggesting a broader set of housekeeping and signaling roles but with a core emphasis on cell-cycle\u2013coupled organelle dynamics. Overall, the common theme centers on cell division coordinated with intracellular organization, especially mitochondria.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":11},{"id":"GO:0000055","count":10},{"id":"GO:0048312","count":10},{"id":"GO:0007049","count":9},{"id":"GO:0032456","count":8}]},{"hash":"2278589479156647740","title":"Chloroplast Photorespiration and Plastid Metabolism","description":"The GO terms are dominated by photorespiration and related plastid-centric metabolism, including oxidative photosynthetic carbon pathways, glycolate catabolism, and peroxisome/plastid-linked oxidation processes, plus amino acid biosynthesis (glutamate) and ammonia assimilation. This combines carbon flux, redox balance, and essential plastid metabolism typical of plant chloroplast networks.","confidence":"High","size":21,"edges":26,"triangles":12,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":14},{"id":"GO:0001561","count":13},{"id":"GO:0019516","count":13},{"id":"GO:0008299","count":13},{"id":"GO:0009853","count":13}]},{"hash":"672605679805871805","title":"Sugar and osmotic stress response","description":"The cluster shows enrichment for responses to sucrose, mannitol, sorbitol, flooding, and related stresses, suggesting a shared mechanism of osmotic and sugar signaling. Mycothiol biosynthesis and lipid biosynthetic processes imply redox defense and metabolic remodeling during stress adaptation.","confidence":"Medium","size":21,"edges":7,"triangles":2,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007631","count":5},{"id":"GO:0009413","count":5},{"id":"GO:0010125","count":5},{"id":"GO:0010555","count":5},{"id":"GO:0033577","count":5}]},{"hash":"1384302722346665453","title":"Endothelial barrier and vascular signaling","description":"Top GO terms point to endothelial barrier establishment, vasoconstriction regulation, adrenergic receptor signaling, Rac/Ral GTPase signaling, and PI(4,5)P2 turnover, indicating a cohesive theme of vascular signaling and endothelial function among the proteins. A couple of terms like glomerulus development and vitellogenesis are more general or organism-specific annotations, but do not override the central vascular theme. Overall, the cluster seems to represent proteins involved in endothelial integrity and vascular signaling processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090557","count":2},{"id":"GO:0051770","count":2},{"id":"GO:0045907","count":2},{"id":"GO:0071880","count":1},{"id":"GO:0032485","count":1}]},{"hash":"1693530204834573822","title":"Ion and Small Molecule Transporters","description":"The terms center on transmembrane transport of ions (K+, Na+), small molecules and metabolites (sialic acid, nitrite/nitrate, xenobiotics, 4-hydroxyphenylacetate), and even neurotransmitter loading into vesicles, pointing to a set of membrane transporter proteins with diverse substrates.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0015739","count":5},{"id":"GO:0015707","count":4},{"id":"GO:0006855","count":4}]},{"hash":"836195501222327908","title":"Motor neuron axon guidance and migration","description":"Top GO terms cluster around motor neuron axon guidance, PNS neuron axonogenesis, and lateral motor column neuron migration, with supporting roles for cell-matrix adhesion and receptor clustering. This suggests a cohesive set of proteins involved in motor neuron development and axon pathfinding, coordinated by adhesion and signaling interactions.","confidence":"High","size":21,"edges":190,"triangles":997,"max_degree":20,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0031581","count":8},{"id":"GO:0034446","count":8},{"id":"GO:0043113","count":8},{"id":"GO:0007160","count":8}]},{"hash":"1168648286356930540","title":"Steroid Hormone Biosynthesis and Vitamin D Metabolism","description":"This cluster centers on steroid hormone production (notably aldosterone) and vitamin D-related processes, including aldosterone biosynthesis/regulation of blood volume and vitamin D response/catabolism. Oxylipin biosynthesis adds a lipid mediator aspect, suggesting broader lipid-signaling roles. While a few terms (e.g., macrophage chemotaxis regulation, isoquinoline alkaloid metabolism) appear peripheral, the dominant theme is endocrine and lipid-derived metabolism, supporting the chosen label.","confidence":"Medium","size":21,"edges":12,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":21},{"id":"GO:0031408","count":21},{"id":"GO:0010164","count":21},{"id":"GO:0032342","count":21},{"id":"GO:0002017","count":21}]},{"hash":"1453705399640463493","title":"Ribosome Biogenesis and Chromatin Regulation","description":"The top GO terms cluster around ribosome-related processes: tRNA pseudouridine synthesis, translation, and nucleolar rRNA transcription by RNA Pol I, suggesting involvement in ribosome assembly and function. Additional terms point to chromatin organization and transcriptional regulation, indicating a broader nuclear regulatory module that links ribosome biogenesis with chromatin state. Some terms appear as outliers (collagen catabolic process, viral RNA genome replication, dosage compensation), but the core pattern supports a ribosome-biogenesis\u2013chromatin regulation theme.","confidence":"Medium","size":21,"edges":190,"triangles":992,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0031119","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0034396","count":1},{"id":"GO:0034724","count":1},{"id":"GO:0030574","count":1}]},{"hash":"548442828460306005","title":"Neural sensory perception and signaling","description":"Strong enrichment for sensory perception (pain, vision) and signaling pathways (ERK cascade, prostaglandin response, morphine) indicates a neural sensorimotor/signaling theme. While a few items touch on metabolism or development, the dominant pattern is brain-associated perception and signal transduction.","confidence":"High","size":21,"edges":86,"triangles":68,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0071502","count":17},{"id":"GO:0002024","count":17},{"id":"GO:0008542","count":16},{"id":"GO:0002035","count":16}]},{"hash":"51951127487314046","title":"Organogenesis and Cardiovascular Morphogenesis","description":"The top terms largely cluster around organ and tissue formation, including coronary artery morphogenesis, cardiac right atrium morphogenesis, foregut morphogenesis, multicellular organism development, and cell\u2013cell adhesion, suggesting a developmental/morphogenetic program with a focus on cardiovascular and organ formation. Some redox-related terms appear but are less coherent with the central theme, so the label emphasizes organogenesis with a cardiovascular emphasis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0098869","count":9},{"id":"GO:0043931","count":7},{"id":"GO:0044332","count":7},{"id":"GO:0060982","count":7}]},{"hash":"1405091371156208037","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":55,"triangles":33,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033076","count":9},{"id":"GO:0034354","count":9},{"id":"GO:0051384","count":9},{"id":"GO:0007623","count":9},{"id":"GO:0006587","count":9}]},{"hash":"282843898064431510","title":"Antibiotic biosynthesis and sporulation cluster","description":"This cluster is dominated by GO terms for antibiotic biosynthesis and sporulation (formation of spores), plus related responses to antibiotics. While there are outliers including lipid biosynthesis and alkaloid-related processes, the strongest and most recurrent signals point to bacterial secondary metabolism and sporulation as the core theme, suggesting a group of proteins involved in producing antibiotics and forming spores under stress. ","confidence":"Medium","size":21,"edges":5,"triangles":1,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030435","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0030324","count":4}]},{"hash":"274925591431197738","title":"Innate Immunity and Inflammatory Signaling","description":"The cluster is dominated by terms linking innate immune response, inflammation, and signaling pathways (NF-kappaB and JNK), plus cytokine activity (IL-17) and barrier dynamics, suggesting proteins function together in immune activation and inflammatory signaling; occasional extracellular matrix term may reflect tissue remodeling during inflammation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0051092","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0046330","count":4}]},{"hash":"1024181829416067793","title":"Skeletal muscle development and ubiquitin regulation","description":"The cluster is dominated by muscle-development terms (sarcomere organization, skeletal muscle cell differentiation, skeletal muscle tissue development) and ubiquitin-related processes (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, negative regulation of protein ubiquitination). This suggests proteins involved in muscle formation whose activity is modulated by ubiquitination, with some additional development-related terms in other tissues. Confidence is moderate because while the muscle theme is strong, the presence of non-muscle terms adds ambiguity.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0045214","count":10},{"id":"GO:0072156","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0035914","count":10}]},{"hash":"497993306905227512","title":"Cardiac morphogenesis and vascular differentiation","description":"The top GO terms concentrate on heart development (right atrium morphogenesis, heart field regulation) and venous endothelial differentiation, plus Notch signaling and mechano-responsive processes, suggesting a cluster of proteins involved in cardiac morphogenesis and heart-associated vascular development. Additional terms reflect broader signaling regulation, common in developmental pathways.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003213","count":9},{"id":"GO:0060843","count":9},{"id":"GO:0010745","count":9},{"id":"GO:0003270","count":9},{"id":"GO:0071260","count":9}]},{"hash":"1390551809335186863","title":"Lymphoid organ development and immune regulation","description":"This cluster is characterized by GO terms tied to lymphoid organ formation (lymph node and spleen development), T cell homeostasis, and inflammatory responses, along with regulatory effects on NF-kappaB signaling and necroptosis. These collectively point to immune system development and control of inflammatory signaling rather than metabolism or other processes, making an immune-regulatory cluster a coherent label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048535","count":3},{"id":"GO:0048536","count":3},{"id":"GO:0097194","count":3},{"id":"GO:0006954","count":2},{"id":"GO:1901740","count":2}]},{"hash":"220289135806755310","title":"Axon Guidance and Synapse Formation","description":"The cluster\u2019s top GO terms center on neural development and connectivity (corpus callosum development, synapse assembly, axonal fasciculation, and regulation of axon-related processes), suggesting the proteins function together in axon pathfinding and synaptogenesis, despite some incidental transport/heart-related terms.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0048681","count":3},{"id":"GO:0006469","count":3}]},{"hash":"1750448006678025111","title":"Unknown","description":"The top GO terms in this cluster are a mix of telomere maintenance/localization, spindle assembly, calcium release, and various signaling pathways (ephrin/GPCR), with some obsolete terms. There is no clear, single cohesive function tying all members together, so a concise, representative label cannot be determined.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":7},{"id":"GO:1900383","count":7},{"id":"GO:0051225","count":7},{"id":"GO:0032212","count":7},{"id":"GO:1904743","count":7}]},{"hash":"46659958918090465","title":"Placental and Embryonic Development","description":"This cluster shows strong enrichment for placental and embryonic development terms, including trophoblast giant cell differentiation, placental/embryonic patterning (left/right formation), embryonic placenta development, and heart-related EMT. Additional terms point to broader organogenesis and endocrine system development, with some RNA processing/regulatory roles that often accompany developmental programs. Together, they suggest proteins involved in placental and embryonic development processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":18},{"id":"GO:0060972","count":17},{"id":"GO:0003323","count":17},{"id":"GO:0060806","count":17},{"id":"GO:0060536","count":17}]},{"hash":"247653761750455981","title":"Growth and development with metabolic remodeling","description":"The proteins touch broad themes of growth and development (multicellular development, glandular maturation, cell proliferation) alongside core metabolic and RNA-processing activities (rRNA maturation, RNA methylation, lipid remodeling). This suggests a general cluster around growth/differentiation coupled with metabolic remodeling rather than a single, specific pathway. Confidence: Medium","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0001403","count":2}]},{"hash":"1283090722681827154","title":"Developmental Growth Factor Signaling","description":"The proteins cluster around receptor-mediated signaling pathways involved in development and morphogenesis, including PDGF and HGF signaling, BMP and Wnt pathways, and placental branching morphogenesis. This suggests a coherent theme of growth-factor\u2013driven developmental signaling, even though a few terms reflect unrelated processes (lipid regulation, immune activation). ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060672","count":4},{"id":"GO:0048168","count":4},{"id":"GO:0048008","count":3},{"id":"GO:0048012","count":3},{"id":"GO:0007567","count":3}]},{"hash":"1317052525228245473","title":"Placental and embryonic tissue differentiation","description":"The GO terms are dominated by placental/trophoblast differentiation and broader embryonic development processes (endocrine system development, left-right patterning, morphogenesis, and EMT-related events). This points to a cohesive theme of embryonic tissue differentiation with a strong emphasis on placental formation and associated lineages, rather than unrelated pathways.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0046661","count":2},{"id":"GO:0007166","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2}]},{"hash":"2061098115390127118","title":"Placental and Embryonic Development","description":"The GO terms are dominated by placental-related processes (trophoblast giant cell differentiation; embryonic placenta development; negative regulation of differentiation in placenta) and broad embryogenesis (left/right pattern formation; endocrine system development; EMT in heart formation; cartilage morphogenesis). This points to a cohesive cluster of proteins functioning in placental formation and overall embryonic patterning, with ancillary roles in endocrine and heart development.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":7},{"id":"GO:0060972","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"1526806962955576683","title":"Tissue morphogenesis and development","description":"Proteins in this cluster are tied to processes of tissue formation and remodeling across multiple systems: skeletal development, angiogenesis and coronary morphogenesis, neural axon guidance, and skin/keratinocyte differentiation, with supporting roles in cell migration and hormonal/regulatory signaling. Although some terms reflect broader responses (pain perception, vitamin D, FSH), the strongest, recurring theme is morphogenesis and developmental differentiation across tissues.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001501","count":13},{"id":"GO:0048846","count":12},{"id":"GO:0002042","count":12},{"id":"GO:0060982","count":12},{"id":"GO:0043154","count":12}]},{"hash":"796184157466164244","title":"Oxidative Stress and Vascular ECM Regulation","description":"The cluster centers on GO terms related to oxidative stress responses (response to hydrogen peroxide, hydrogen peroxide catabolic process, response to toxic substance) and tissue maintenance, including vascular homeostasis (blood vessel diameter maintenance, blood coagulation) and extracellular matrix/fibrosis regulation (negative regulation of collagen biosynthetic process, hepatic stellate cell activation, fibroblast migration). Oxygen transport and renal absorption are adjacent themes that fit within tissue maintenance contexts. Together they suggest proteins involved in managing oxidative stress while preserving vascular function and restraining fibrotic remodeling, making this a coherent, cohesive group.","confidence":"Medium","size":20,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042542","count":3},{"id":"GO:0050880","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0070293","count":2},{"id":"GO:0032966","count":2}]},{"hash":"1402796520276025776","title":"Methyltransferases across RNA, protein, and B12 biosynthesis","description":"Top GO terms cluster around various methylation processes (rRNA and tRNA methylation, histone methylation, peptidyl methylation), indicating enzymes that transfer methyl groups to RNA or proteins. Additional terms for cobalamin (B12) and antibiotic biosynthesis suggest methylation steps in biosynthetic pathways. Together these imply a cohesive group of methyltransferases acting on diverse substrates, rather than a single substrate class. ","confidence":"High","size":20,"edges":59,"triangles":70,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031167","count":6},{"id":"GO:0009236","count":6},{"id":"GO:0043985","count":5},{"id":"GO:0030488","count":5},{"id":"GO:0046690","count":5}]},{"hash":"1029784991570729234","title":"Neural development and synapse assembly","description":"This cluster is enriched for CNS development terms, including positive regulation of synapse assembly, CNS projection neuron axonogenesis, and corpus callosum development, indicating roles in neural connectivity. The presence of cell\u2013cell and cell\u2013matrix adhesion and ECM organization terms further supports neural tissue structuring, while a few non-CNS terms appear peripheral.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":11},{"id":"GO:0007507","count":10},{"id":"GO:0022038","count":10},{"id":"GO:0071372","count":10},{"id":"GO:0021952","count":10}]},{"hash":"667017947001231094","title":"Neural development and MAPK signaling","description":"This cluster shows nervous system development, synapse assembly regulation, and positive regulation of ERK/MAPK signaling, along with other development-related terms (angiogenesis, multicellular development) and cytoskeletal signaling (Rho). Immune-related terms are present but secondary, suggesting the core theme is neural development and associated signaling pathways.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0070374","count":3}]},{"hash":"1888462758018797998","title":"Bacterial central metabolism and quinone biosynthesis","description":"Enriched terms point to core energy metabolism (glycolysis, beta-oxidation, oxaloacetate) and quinone cofactor biosynthesis (menaquinone, phylloquinone), alongside multiple amino-acid/aromatic compound catabolic pathways. The cluster thus seems to capture prokaryotic energy generation and redox-cofactor production, with a secondary signal of antibiotic biosynthesis possible. ","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":13},{"id":"GO:0006635","count":9},{"id":"GO:0010124","count":8},{"id":"GO:0006574","count":8},{"id":"GO:0009234","count":8}]},{"hash":"554801725046458185","title":"RyR-regulated calcium signaling","description":"This cluster is dominated by terms about regulation of ryanodine receptor\u2013mediated calcium release, plus related calcium signaling roles in synaptic plasticity (LTP, EPSP) and tissues like heart and Schwann cells. The recurring theme is Ca2+-dependent signaling that controls excitation, muscle/neuronal function, and development, making RyR-regulated calcium signaling a concise, representative label.","confidence":"High","size":20,"edges":6,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060316","count":10},{"id":"GO:0060315","count":10},{"id":"GO:0042994","count":10},{"id":"GO:0043388","count":9},{"id":"GO:0007507","count":8}]},{"hash":"1049263896244561529","title":"Chromosome cohesion and division machinery","description":"The top GO terms center on chromosome dynamics\u2014meiotic sister chromatid cohesion, centromeric, and establishment of protein localization to chromosomes\u2014as well as septin ring disassembly, which together point to chromosome segregation and cytokinesis. Additional terms about proton transport and vacuolar acidification suggest general energy and membrane processes that support division, but the dominant signal is chromosome cohesion/localization and division-related cytoskeleton functions.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":6},{"id":"GO:0015991","count":4},{"id":"GO:0006470","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0043536","count":3}]},{"hash":"27709956200237791","title":"Nuclear transport and mitosis regulation","description":"This cluster is enriched for GO terms related to nuclear import/export (NLS-bearing protein import into nucleus, ribosomal protein import into nucleus, regulation of protein export from nucleus) and mitotic chromosome movement, with additional signals from ribosome biogenesis and related regulatory processes, suggesting a theme around nuclear-cytoplasmic transport linked to mitosis and ribosome assembly.","confidence":"Medium","size":20,"edges":92,"triangles":281,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:1902775","count":3},{"id":"GO:0042176","count":3},{"id":"GO:0060188","count":3},{"id":"GO:0006607","count":3}]},{"hash":"925361320765148829","title":"Developmental signaling and morphogenesis","description":"The GO terms emphasize developmental processes (spermatid development, hippocampus development, epithelial morphogenesis, cytogamy) and regulation of signaling pathways (PKA signaling, NF-kappaB regulation, phosphorylation), suggesting a cluster of proteins involved in coordinating development and tissue remodeling through signaling. Some terms point to neural/synaptic function and metabolism, with one glucan biosynthetic regulation term likely representing annotation noise.","confidence":"Medium","size":20,"edges":26,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:0007286","count":3},{"id":"GO:0010738","count":3},{"id":"GO:0033138","count":3},{"id":"GO:0021766","count":3}]},{"hash":"427589243356131546","title":"Cell fate signaling and cytoskeletal dynamics","description":"The GO terms point to regulated apoptosis (neuronal and hepatocyte), cell cycle, response to mechanical stimulus, membrane addition at cytokinesis, filopodium assembly, endocytosis, and ERK signaling, all contributing to how cells decide survival vs. death while coordinating division and cytoskeletal remodeling in response to mechanical cues to maintain tissue homeostasis.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0007107","count":2},{"id":"GO:0051489","count":2}]},{"hash":"1105310846172454847","title":"Ribosome Biogenesis and LSU Maturation","description":"The dominant GO terms are ribosome biogenesis (GO:0042254), maturation of LSU-rRNA (GO:0000463), and assembly of large subunit precursors (GO:1902626). These point to a shared function in ribosome assembly and rRNA processing, suggesting the cluster groups proteins involved in ribosome biogenesis. Other terms in the list involve viral entry/uncoating and leukocyte migration, which are less central to the core theme and may reflect annotation noise or multifunctionality. Overall, the core signal is ribosome biogenesis and LSU maturation.","confidence":"Medium","size":20,"edges":151,"triangles":630,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0006278","count":5},{"id":"GO:1901407","count":5},{"id":"GO:0075713","count":5}]},{"hash":"55647791682879083","title":"Translation Initiation and Reinitiation","description":"The dominating GO terms point to translation initiation and its regulation, including reinitiation and IRES-dependent initiation, plus formation of the preinitiation complex and viral reinitiation events. A few other terms (TORC1 signaling, spliceosome-related processes, and ERAD-related pathways) appear, but the core theme remains initiation of translation and its control.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0075522","count":6},{"id":"GO:0075525","count":5},{"id":"GO:0006446","count":5}]},{"hash":"476233668315209271","title":"Embryonic organogenesis and transcription regulation","description":"This cluster shows enrichment for developmental processes (endocrine pancreas development, pituitary gland development, neural crest cell migration, embryonic digestive tract morphogenesis) alongside transcriptional control (DNA-templated transcription, transcription regulation, chromatin remodeling). The combination points to proteins that coordinate gene expression programs during embryogenesis and organ formation, making a developmental transcription regulation label appropriate.","confidence":"Medium","size":20,"edges":141,"triangles":521,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0006351","count":10},{"id":"GO:0031018","count":8},{"id":"GO:0090190","count":7},{"id":"GO:0001755","count":7}]},{"hash":"1625944415583288505","title":"Neuroimmune-Sensory Signaling","description":"The cluster shows enrichment across photoreceptor maintenance, vasopressin-regulated blood pressure, temperature response, immune modulation (IL-1\u03b2 production, dendritic cell differentiation), GPCR-related signaling (adenylate cyclase-inhibiting opioid receptor pathway, PKA activity), sensitization, and coagulation, suggesting a broad signaling network linking nervous, immune, and endocrine/sensory functions.","confidence":"Medium","size":20,"edges":45,"triangles":15,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":18},{"id":"GO:0001992","count":18},{"id":"GO:0071502","count":18},{"id":"GO:0032651","count":18},{"id":"GO:0097029","count":18}]},{"hash":"963067643571808743","title":"Lipid metabolism and oxidative stress response","description":"The terms cluster around lipid processing (triglyceride catabolic process, fatty acid beta-oxidation, bile acid metabolism, lysophospholipid transport) and oxidative stress defenses (response to hydrogen peroxide, cellular oxidant detoxification, hypoxia response), suggesting a combined role in lipid metabolism with redox/homeostatic responses.","confidence":"Medium","size":20,"edges":11,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":12},{"id":"GO:0019433","count":10},{"id":"GO:0008284","count":9},{"id":"GO:0032000","count":8},{"id":"GO:0043154","count":8}]},{"hash":"1225298715334510761","title":"mRNA Splicing Regulation","description":"This cluster shows strong enrichment for spliceosome\u2011mediated mRNA processing and regulation, with terms covering regulation of mRNA splicing (including alternative splicing), mRNA stability, and RNA processing steps like splicing and polyadenylation. The presence of regulatory ncRNA\u2011mediated gene silencing suggests coordinated post-transcriptional control. Overall, these proteins likely act as regulators of RNA maturation and transcript stability via the spliceosome.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":17},{"id":"GO:0048026","count":17},{"id":"GO:0010610","count":17},{"id":"GO:0006378","count":16},{"id":"GO:0045292","count":16}]},{"hash":"2059182078804236805","title":"Organogenesis and Morphogenesis Signaling","description":"These proteins cluster around organ development and morphogenesis (heart, kidney, nipple, lymph vessel morphogenesis) and show enrichment for signaling pathway terms (ERK1/2 cascade, IP3 biosynthesis, adenylate cyclase activation). The common theme is developmental processes across multiple organs with regulation by intracellular signaling.","confidence":"High","size":20,"edges":30,"triangles":0,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0072237","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0006954","count":3}]},{"hash":"230755278356115256","title":"Developmental signaling and tissue formation","description":"The prominent GO terms cluster around multicellular development, including skeletal muscle fiber development and neural crest formation, which points to broad developmental and tissue formation processes. Additional terms like positive regulation of cell proliferation, phosphorylation signaling, glucocorticoid response, and N-glycan processing suggest coordinated regulation of cellular maturation and signaling during development, with some kinesthetic and neural/immune system overlap. While there are ancillary terms (glycan processing, nuclear import) that are not strictly developmental, the dominant theme is developmental signaling and tissue formation.","confidence":"Medium","size":20,"edges":184,"triangles":1040,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0006491","count":3},{"id":"GO:0008284","count":2},{"id":"GO:0007613","count":2}]},{"hash":"841928858729222857","title":"Presynaptic Vesicle Release and Active Zone Organization","description":"This cluster is dominated by GO terms tied to presynaptic function: synaptic vesicle clustering, positive regulation of synaptic vesicle exocytosis, neurexin clustering for presynaptic membrane assembly, and cytoskeletal organization at the active zone. These points together to a coherent theme of vesicle handling and structural organization at the presynaptic site, with a minor set of outlier terms likely reflecting broader or incidental annotations. Overall, the label captures the main shared function of the proteins in this group.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:1902474","count":17},{"id":"GO:0097091","count":17},{"id":"GO:2000302","count":17},{"id":"GO:0051384","count":17},{"id":"GO:0043279","count":17}]},{"hash":"591662155730586023","title":"Embryonic patterning and organ morphogenesis","description":"These proteins cluster around multiple embryonic development processes\u2014left/right pattern formation, endocrine system development (pancreatic, placental), heart-related EMT, cartilage morphogenesis, and neural development\u2014suggesting a general theme of embryogenesis and tissue morphogenesis rather than a single pathway. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060707","count":8}]},{"hash":"1762370816252396562","title":"Aldosterone Biosynthesis and Vitamin D Metabolism","description":"The cluster is dominated by terms about aldosterone biosynthesis and renal regulation of blood volume, along with response to and catabolism of vitamin D, pointing to a core theme of endocrine steroid metabolism and vitamin D handling. Additional terms such as oxylipin biosynthesis and oxidative demethylation suggest lipid signaling and xenobiotic metabolism, while mammary gland development and macrophage chemotaxis regulation reflect broader immune-hormonal interactions. Overall, the pattern centers on steroid/endocrine metabolism with vitamin D connections.","confidence":"Medium","size":20,"edges":180,"triangles":971,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":17},{"id":"GO:0031408","count":17},{"id":"GO:0010164","count":17},{"id":"GO:0032342","count":17},{"id":"GO:0002017","count":17}]},{"hash":"550824981554718674","title":"Developmental signaling and innate immunity","description":"Proteins in this cluster are linked to innate immune response and multiple signaling regulators (Wnt, JNK, GTPase activity, JUN phosphorylation), plus apoptosis and developmental processes (heart, uterus, bone). The shared theme appears to be signal transduction governing development and stress responses with an innate immune component, making a Developmental signaling and innate immunity cluster a concise, representative label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0015707","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0046328","count":3}]},{"hash":"2245666547934100969","title":"Membrane Transport and Signaling Regulators","description":"The top GO terms point to membrane-associated transport activities (nitrite, xenobiotic, and metabolite transport) alongside signaling pathways (GPCR\u2013calcium signaling and Rho-mediated signaling). This suggests a coherent theme of proteins that modulate transport across membranes and linked signaling processes, with some tissue-specific terms (development and myelination) as possible outliers. Overall, the cluster seems centered on transport coupled with signaling regulation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":3},{"id":"GO:0051281","count":3},{"id":"GO:0010579","count":2},{"id":"GO:0035025","count":2},{"id":"GO:0072205","count":2}]},{"hash":"1180990491652748332","title":"Immune Receptor and RTK Signaling","description":"The cluster shows enrichment for immune-related signaling terms (innate immune response; B cell receptor signaling) alongside receptor tyrosine kinase\u2013linked pathways (ephrin receptor signaling) and downstream signaling (PI3K, STAT phosphorylation, MAPK). This points to a module of RTK and immune-receptor signaling networks, though a few terms (myelination, skeletal development) are less connected to this core theme. ","confidence":"Medium","size":20,"edges":9,"triangles":0,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0042552","count":6},{"id":"GO:0038162","count":5},{"id":"GO:0001501","count":5}]},{"hash":"89154443958787766","title":"Unknown","description":"The GO terms span neural structure (synapse organization, paranodal junction assembly), immune signaling (T cell costimulation, erythropoietin signaling, STAT phosphorylation), metabolism (triglyceride catabolic process), pigment cell biology (melanocyte differentiation and adhesion), and host interaction (symbiont entry into host cell). There isn\u2019t a single coherent function tying these terms together, suggesting a heterogeneous cluster without a clear shared theme.","confidence":"","size":20,"edges":43,"triangles":6,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050808","count":6},{"id":"GO:0030913","count":6},{"id":"GO:0031295","count":6},{"id":"GO:0032516","count":6},{"id":"GO:0046718","count":6}]},{"hash":"1818017075426027275","title":"Microbial metabolite biosynthesis and lipid metabolism","description":"The top GO terms cluster around biosynthetic pathways such as ectoine and siderophore production, as well as fatty acid biosynthesis and related lipid metabolism. There are also catabolic processes for small carboxylates like malonate and phenylacetate, which fits a broad bacterial metabolism theme. Some terms appear obsolete or plant-related, likely noise, but the prominent signals point to microbial biosynthesis and lipid-associated metabolism.","confidence":"Medium","size":20,"edges":84,"triangles":118,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902987","count":7},{"id":"GO:0019491","count":7},{"id":"GO:0019427","count":6},{"id":"GO:0010124","count":6},{"id":"GO:0019654","count":6}]},{"hash":"303594550298335875","title":"Neurovascular development and synapse formation","description":"Top GO terms cluster around neural retina development, synapse assembly, and morphogenesis with angiogenesis and extracellular matrix remodeling, suggesting a cohesive theme of neural-vascular development rather than a single specialized process.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0061074","count":20},{"id":"GO:0071318","count":20},{"id":"GO:0007275","count":20},{"id":"GO:1903672","count":20},{"id":"GO:0044537","count":20}]},{"hash":"123313133191097965","title":"Unknown","description":"The terms are a mix of apoptosis regulation, development (spinal cord and blastocyst), RNA processing, and metabolism, with no clear shared function or cohesive theme across the 20 proteins, and no interactions among them; therefore a specific label cannot be confidently assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902043","count":4},{"id":"GO:0019700","count":3},{"id":"GO:0090502","count":3},{"id":"GO:0008033","count":3},{"id":"GO:2001241","count":3}]},{"hash":"1185508631362302078","title":"Neural and Cardiac Development and Synaptic Signaling","description":"Top GO terms suggest roles in nervous system development, synaptic potentiation, heart development, and cytoskeletal/adhesion processes, indicating a focus on development and function in excitable tissues with supporting structural organization. A concise label that captures these themes is appropriate.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0007155","count":4},{"id":"GO:0045162","count":4},{"id":"GO:0045214","count":3}]},{"hash":"2105269732374297762","title":"Ubiquitin-Dependent Immune Regulation","description":"Top GO term is ubiquitin-dependent protein catabolic process (18), aligned with multiple immune-related terms (pro-T cell differentiation, type 2 immune response, memory T cell differentiation, IgE isotype switching, and mast cell cytokine regulation). This points to a cluster of proteins whose primary function involves ubiquitin-mediated protein turnover that modulates adaptive immune signaling. Some non-immune terms (distal tubule morphogenesis, renal sodium absorption, female development) may reflect annotation noise or pleiotropy, but the dominant signal is immune regulation via ubiquitination.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0048294","count":12},{"id":"GO:2000176","count":12},{"id":"GO:0042092","count":12},{"id":"GO:0009958","count":12}]},{"hash":"768211407780106726","title":"Type 2 immune regulation and T cell differentiation","description":"Most terms point to adaptive immune control, including pro-T and memory T cell differentiation, type 2 immunity, IgE isotype switching, and mast cell cytokine regulation. A few terms are general cellular processes that may be broader annotations, but the dominant pattern reflects immune system regulation in T cells and allergic-type responses.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0048294","count":13},{"id":"GO:2000176","count":13},{"id":"GO:0042092","count":13},{"id":"GO:0009958","count":13}]},{"hash":"2067708699985619243","title":"Lipid mediator biosynthesis","description":"The top GO terms center on prostaglandin and oxylipin biosynthesis, along with aldosterone biosynthesis and related renal regulation, indicating production of lipid mediators and steroid hormones. While some terms touch xenobiotic metabolism and immune regulation, the dominant pattern ties to lipid mediator biosynthesis (prostaglandins/oxylipins) and steroid hormone pathways, justifying this label.","confidence":"High","size":20,"edges":15,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":18},{"id":"GO:0001516","count":18},{"id":"GO:0033076","count":17},{"id":"GO:0031408","count":17},{"id":"GO:0010164","count":17}]},{"hash":"224142000499931516","title":"Reproductive tissue development and hormone signaling","description":"Contains uterus and mammary gland development terms, along with aldosterone and vitamin D\u2013related hormone pathways, suggesting endocrine regulation of reproductive tissues; oxylipin biosynthesis adds lipid signaling context.","confidence":"Medium","size":20,"edges":10,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":18},{"id":"GO:0033076","count":17},{"id":"GO:0031408","count":17},{"id":"GO:0010164","count":17},{"id":"GO:0032342","count":17}]},{"hash":"327830208502557350","title":"GPCR-cAMP signaling in blood pressure regulation","description":"The top GO terms center on adenylate cyclase-activating GPCR signaling and activation of adenylate cyclase, with clear ties to the regulation of systemic arterial blood pressure by vasopressin. This points to a cohesive theme of GPCR-mediated cAMP signaling influencing vascular function and blood pressure. The other terms (retina maintenance and immune cell differentiation) reflect tissue-specific roles of GPCR signaling, but do not overwhelm the central cardiovascular signaling pattern. Overall, the cluster seems best described as a GPCR-cAMP\u2013driven blood pressure regulation module.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0007190","count":18},{"id":"GO:0045494","count":16}]},{"hash":"960638291557860390","title":"Ribosome biogenesis and translation","description":"The cluster is enriched for ribosome-related processes (cytoplasmic translation, export of the large ribosomal subunit from the nucleus) and RNA processing (mRNA processing) with supporting terms like protein ubiquitination and cell cycle; together they point to a coordination of ribosome biogenesis, mRNA maturation, and protein synthesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":3}]},{"hash":"526218183185092499","title":"Immune signaling and vascular remodeling","description":"The terms cluster around adaptive immune response, ERK1/ERK2 cascade regulation, and processes related to inflammation and cell adhesion, as well as angiogenesis and extracellular matrix components like heparin proteoglycan biosynthesis. Together these points suggest a theme where immune cell signaling modulates inflammation and blood vessel remodeling. A couple of terms (sensory perception of sound and transcriptional regulation) are less directly aligned and may reflect broader multifunctionality or noise, but the dominant pattern supports an immune-signaling with vascular remodeling theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0090331","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0007605","count":2}]},{"hash":"1556027813498186870","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071901","count":8},{"id":"GO:0034260","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0007568","count":6},{"id":"GO:0006469","count":6}]},{"hash":"966550425749402611","title":"Ubiquitin-Dependent Proteolysis and NF-\u03baB Signaling","description":"This cluster is dominated by GO terms for ubiquitin-mediated proteolysis and ubiquitination events (including different linkages and autoubiquitination), plus ERAD, histone ubiquitination, and regulation of TNF signaling and NF-\u03baB activation. These terms point to a cohesive theme of ubiquitin tagging leading to protein degradation and the regulation of NF-\u03baB signaling pathways. Confidence: High.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0036205","count":17},{"id":"GO:1903265","count":17},{"id":"GO:0085020","count":17},{"id":"GO:0051865","count":17}]},{"hash":"1703228614787051362","title":"Metabolic and Cardiovascular Signaling","description":"The cluster centers on signaling and metabolic regulation, with GO terms for GPCR-mediated adenylate cyclase activation, electron transport/metabolic energy, and blood-pressure control via vasopressin, plus related pathways like Rho signaling and thermogenesis. While there are sensory and inflammatory terms (pain, photoreceptor maintenance, IL-1\u03b2), the strongest cohesive theme is integrated signaling that governs energy metabolism and cardiovascular/homeostatic functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0045777","count":9},{"id":"GO:0035025","count":7},{"id":"GO:0071502","count":6}]},{"hash":"1148214888404344010","title":"Ubiquitin-proteasome mediated stress in development","description":"This cluster combines ubiquitin-proteasome pathway terms (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination) with stress- and apoptosis-related signals (ER stress\u2013induced apoptotic signaling; G1 DNA damage checkpoint signaling) and development-associated processes (multicellular organism development, neural tube closure, glial apoptotic processes). The common thread appears to be regulation of protein turnover and signaling that tie stress responses to developmental processes, rather than a single, narrow function. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":7},{"id":"GO:0031146","count":7},{"id":"GO:0007584","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0071560","count":6}]},{"hash":"1466557349628259739","title":"Embryonic patterning and organ morphogenesis","description":"The top GO terms cluster around developmental processes: left/right pattern formation, endocrine system development (including pancreas), EMT in heart cushion formation, trophoblast differentiation, placental development, and cartilage morphogenesis. While a couple terms reference complement pathways, the dominant theme is embryonic patterning and tissue morphogenesis, suggesting these proteins collectively participate in early development and organ formation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060707","count":8}]},{"hash":"1181760974376743363","title":"Neuronal signaling and synaptic plasticity","description":"The GO terms converge on EGFR-related signaling, angiogenesis, small GTPase-mediated signal transduction, and neuronal development/plasticity (dendritic spine growth, long-term memory, synaptic plasticity). This suggests a cluster of proteins involved in neuronal signaling networks and activity-dependent plasticity, with some transcription initiation components reflecting coordinated gene expression.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007173","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0007264","count":2},{"id":"GO:0060999","count":2},{"id":"GO:0060670","count":2}]},{"hash":"1660324503222227933","title":"Innate Immune NF-kappaB Signaling","description":"The top terms center on innate immune response and positive regulation of canonical NF-kappaB signaling, suggesting proteins that participate in immune sensing and NF-kappaB-driven transcription. While there are also terms related to immunoglobulin production, apoptosis regulation, and development, the dominant theme is immune signaling mediated by NF-kappaB.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0002377","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0007568","count":2}]},{"hash":"1736792907113034530","title":"Unknown","description":"The top terms span extracellular matrix/cell adhesion and skin-related processes, plus immune defense and some unrelated functions, yielding no single cohesive theme for the cluster. This mixture suggests an Unknown function label.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045162","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0042742","count":2},{"id":"GO:2000860","count":2}]},{"hash":"236210191967148329","title":"Metanephric Kidney Development","description":"The top GO terms strongly point to kidney and nephron formation (mesonephric duct development, metanephric proximal tubule and ascending limb development), suggesting the cluster is enriched for genes involved in renal organogenesis. A few immune-related terms appear, but they are less central to the main theme. Overall, the dominant signal supports metanephric kidney development.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":19},{"id":"GO:0006910","count":19},{"id":"GO:0072218","count":19},{"id":"GO:0050901","count":19},{"id":"GO:0036303","count":19}]},{"hash":"584316255934114060","title":"Diverse Transmembrane Transport","description":"This cluster clusters GO terms around transport across membranes for multiple substrates, including sugars (fucose, galactose, sialic acid), nitrate/nitrite, xenobiotics, and neurotransmitter loading into synaptic vesicles. The common theme is membrane transport activity affecting a variety of substrates, rather than a single substrate or pathway.","confidence":"Medium","size":19,"edges":25,"triangles":13,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":6},{"id":"GO:0006004","count":6},{"id":"GO:0035435","count":6},{"id":"GO:0015757","count":6},{"id":"GO:0015706","count":6}]},{"hash":"895855252591150573","title":"Cytoskeletal Remodeling in Morphogenesis","description":"The cluster is enriched for actin-related processes (actin filament bundle assembly; lamellipodium assembly) and for morphogenesis across species (haltere morphogenesis; plant ovule morphogenesis) and neural development (midbrain dopaminergic neuron differentiation), suggesting a shared theme of cytoskeletal dynamics driving developmental shape changes. Some other terms (apoptosis, transcription, coagulation) appear incidental or reflect broader cellular contexts.","confidence":"Medium","size":19,"edges":134,"triangles":535,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0090334","count":3},{"id":"GO:1904948","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0042771","count":3}]},{"hash":"1307054640766512432","title":"Calcium-Dependent Signaling and Exocytosis","description":"The top GO terms cluster around calcium-ion dependent processes, including exocytosis and regulation of degranulation, as well as synaptic-like signaling (excitatory postsynaptic potential). Additional terms point to signaling pathways such as ephrin receptor signaling and the JNK cascade, and to processes like focal adhesion regulation. Together these suggest a cohesive module centered on calcium-triggered signaling and vesicle release, with supportive roles in cell adhesion and cytoskeletal dynamics. The mitotic cell cycle term is less cohesive with the main theme, so the label highlights secretion and signaling rather than proliferation. ","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":17},{"id":"GO:0031532","count":16},{"id":"GO:0043304","count":16},{"id":"GO:0043552","count":16},{"id":"GO:0048013","count":16}]},{"hash":"1511797348811367240","title":"Acetylation-Linked Metabolism","description":"The cluster centers on acetylation-related processes (peptidyl-lysine N6-acetylation; spermine acetylation) and several metabolic pathways (glucosamine/N-acetylglucosamine, arginine biosynthesis, mycothiol), suggesting a theme of acetylation-modulated metabolism with broader growth-related regulatory links such as angiogenesis and leaf formation. Confidence: Medium","confidence":"","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":6},{"id":"GO:0006044","count":5},{"id":"GO:0006348","count":4},{"id":"GO:2000025","count":4},{"id":"GO:0046208","count":4}]},{"hash":"1048008117494770105","title":"Developmental Signaling and Actin Regulation","description":"The top GO terms point to developmental processes (myoblast fusion, telencephalon development, multicellular organism development) coupled with signaling pathways (erythropoietin-mediated signaling, regulation of JUN kinase) and cytoskeletal dynamics (actin cytoskeleton reorganization, actin filament binding, cell polarity). This suggests a theme where signaling cues coordinate cytoskeletal remodeling and polarity during development, with translation regulation providing protein synthesis support for these processes.","confidence":"Medium","size":19,"edges":8,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":19},{"id":"GO:0007520","count":19},{"id":"GO:0021537","count":19},{"id":"GO:0045727","count":19},{"id":"GO:0031532","count":19}]},{"hash":"1392915479578357526","title":"Cell cycle control and mitotic spindle regulation","description":"Top terms point to mitosis-related processes (cell cycle, kinetochore/spindle pole body localization, actomyosin ring maturation) and regulation of kinase signaling (MAPK/ERK, CDK activity), indicating a cohesive module governing cell division and spindle dynamics, with some broader signaling connections.","confidence":"High","size":19,"edges":92,"triangles":312,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050860","count":12},{"id":"GO:0035335","count":11},{"id":"GO:0070373","count":10},{"id":"GO:0000200","count":10},{"id":"GO:0045736","count":10}]},{"hash":"13045021573776770","title":"Lipid and Vitamin Biosynthesis","description":"The GO terms cluster around biosynthetic processes, especially lipid biosynthesis (fatty acid elongation, very long-chain fatty acids, sphingolipid biosynthesis) and vitamin-related pathways (retinoic acid and phylloquinone metabolism), with tropane alkaloid biosynthesis also present. A few terms like lung development, transcription regulation, and methotrexate response appear less connected, but the dominant theme is lipid and vitamin biosynthesis across processes, suggesting a metabolic cluster with secondary development-related annotations.","confidence":"Medium","size":19,"edges":69,"triangles":52,"max_degree":11,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":14},{"id":"GO:0030324","count":12},{"id":"GO:0006355","count":12},{"id":"GO:0009710","count":12},{"id":"GO:0042761","count":12}]},{"hash":"388154149422596089","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":14},{"id":"GO:0048026","count":8},{"id":"GO:0031047","count":8},{"id":"GO:0000387","count":8},{"id":"GO:0009845","count":8}]},{"hash":"1029217151341460930","title":"Neuronal development and dendrite morphogenesis","description":"The cluster is strongly enriched for neural-development related GO terms, including ephrin receptor signaling, dendrite development, positive regulation of dendrite morphogenesis, neuronal stem cell maintenance, and Wnt signaling, suggesting a coordinated role in neural differentiation and dendrite formation. Some plant-related terms appear but seem incidental; overall the theme centers on neuronal development and dendrite morphogenesis.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":8},{"id":"GO:0016358","count":8},{"id":"GO:0097150","count":6},{"id":"GO:0009955","count":6},{"id":"GO:1900170","count":6}]},{"hash":"1475204996952138154","title":"Embryonic organ development and CNS maturation","description":"Based on the top GO terms, the proteins are involved in a broad set of developmental processes across multiple organs (heart, kidney, endoderm) as well as central nervous system features (corpus callosum development, myelination, synapse organization). Collagen fibril organization points to extracellular matrix remodeling during development, and hypoxia response and guanylyl cyclase signaling suggest broader developmental regulation. There isn\u2019t a single tight function, but the common thread is embryonic tissue development with notable emphasis on CNS maturation and ECM dynamics, so the label reflects a general developmental theme rather than a specific pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0042552","count":2},{"id":"GO:0007168","count":2}]},{"hash":"249807876441661853","title":"Embryonic Organogenesis and Neurodevelopment","description":"The cluster features GO terms spanning diverse organ development (endocrine pancreas, pituitary, liver, brain, spinal cord, skeletal muscle) alongside neural patterning and broad transcriptional activity. This suggests a cohesive module involved in embryonic tissue formation and CNS specification, rather than a single tissue. The presence of brain and spinal cord development terms anchors its primary theme in neurodevelopment, with additional organogenesis terms indicating a broader developmental program.","confidence":"High","size":19,"edges":75,"triangles":205,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":8},{"id":"GO:0021983","count":7},{"id":"GO:0060441","count":6},{"id":"GO:0006366","count":6},{"id":"GO:0021520","count":6}]},{"hash":"819773980434304155","title":"Neurodevelopment and synaptic signaling","description":"The top terms cluster around nervous system development and synaptic function, including positive regulation of synapse assembly and glutamatergic synaptic transmission, with supporting developmental processes like multicellular organism development and hippo signaling. While several terms point to neural development, others reflect broader developmental contexts (bone maturation, lymph vessel morphogenesis, inflammatory response), suggesting a group of proteins involved in neural development with interconnected growth and signaling roles. Confidence: Medium","confidence":"","size":19,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0043931","count":3},{"id":"GO:0035249","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0035329","count":3}]},{"hash":"448214090218066677","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":17},{"id":"GO:0001519","count":17},{"id":"GO:1902187","count":17},{"id":"GO:1903883","count":17},{"id":"GO:1903265","count":17}]},{"hash":"203861293436462846","title":"Diverse biomolecule and xenobiotic metabolism","description":"The cluster's GO terms point to multiple metabolic pathways, including bile acid, thyroid hormone, catecholamine, flavonoid, N-acetylglucosamine/glycosaminoglycan processing, and xenobiotic metabolism, suggesting a general metabolic/modification role rather than a single specific process.","confidence":"Medium","size":19,"edges":48,"triangles":34,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030573","count":8},{"id":"GO:0006044","count":8},{"id":"GO:0015015","count":8},{"id":"GO:0042403","count":8},{"id":"GO:0030205","count":8}]},{"hash":"138432998103133078","title":"Unknown","description":"The top terms are scattered among DNA replication, viral genome replication, a few mitochondrial ribosome/biogenesis hints, and various catabolic and plant-related processes, with no dominant, cohesive function across the cluster.","confidence":"","size":19,"edges":58,"triangles":29,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0019079","count":2},{"id":"GO:0070584","count":2},{"id":"GO:1902775","count":2},{"id":"GO:0019380","count":1}]},{"hash":"1644433218421585289","title":"Thermoregulation-Linked Neuro-Immune Signaling","description":"The top GO terms span temperature response, thermogenesis, pain sensing, neuronal signaling (membrane potential), retinal maintenance, vasopressin-regulated blood pressure, IL-1\u03b2 production, dendritic cell differentiation, and PKA signaling. This suggests a network intertwining neural sensing, immune modulation, and endocrine control in the context of thermoregulation, rather than a single focused function.","confidence":"Medium","size":19,"edges":129,"triangles":406,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0042391","count":13},{"id":"GO:0045494","count":11}]},{"hash":"1269335217637804917","title":"Axon guidance and myelination","description":"The GO terms are dominated by neural development processes: axon fasciculation, axon target recognition, corpus callosum development, positive regulation of synapse assembly, and myelination, with DNA-templated transcription pointing to neuronal differentiation. While otolith morphogenesis appears, the strongest signal ties to axon pathfinding and subsequent myelin formation during neural development.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0007412","count":2},{"id":"GO:0022038","count":2}]},{"hash":"1430425517134804688","title":"Unknown","description":"The top GO terms include muscle development (skeletal and smooth) alongside immune-related terms (cytokine production, T and B cell activity), with no clear unifying function connecting all proteins and no network edges observed. This mixed signal makes it hard to assign a coherent, specific label. ","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":2},{"id":"GO:0060013","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0048294","count":1},{"id":"GO:0001816","count":1}]},{"hash":"662794252145469760","title":"Unknown","description":"The GO terms cover a broad and seemingly unrelated mix of biosynthetic processes, transcription regulation, stress responses, and development, with no clear common function tying the proteins together. Also, there are no network connections (edges, triangles, or high degree) to suggest a coherent module, supporting an Unknown label.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0000122","count":3}]},{"hash":"1245238967923701017","title":"Neurotransmitter receptor signaling and behavior","description":"This cluster is dominated by GO terms tied to synaptic signaling and behavior: acetylcholine, GABA, and serotonin receptor pathways, postsynaptic membrane organization, and behavioral outputs such as startle, conditioned taste aversion, and walking. The presence of negative regulation of nerve impulse further points to inhibitory modulation within synapses, suggesting a cohesive group of proteins governing neuronal communication and associated behaviors. Vestibulocochlear nerve development also hints at sensory-synaptic connections, reinforcing the neural signaling theme.","confidence":"High","size":19,"edges":169,"triangles":935,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0051970","count":18},{"id":"GO:0001661","count":18},{"id":"GO:0095500","count":18},{"id":"GO:0001964","count":18},{"id":"GO:0007628","count":18}]},{"hash":"1157452147631193010","title":"Embryonic organogenesis and patterning","description":"The top GO terms center on developmental processes and tissue morphogenesis, notably left/right pattern formation, endocrine system development, pancreatic cell development, placenta-related differentiation, endocardial cushion EMT, cartilage morphogenesis, and palate development. Together they point to a cohesive theme of embryonic organogenesis and patterning, with a couple of less central terms (mRNA splicing and vitamin D biosynthesis regulation) that do not undermine the core signal. ","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":14},{"id":"GO:0003323","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0060707","count":14}]},{"hash":"1322700115403817059","title":"Embryonic and Tissue Development","description":"Top terms point to broad developmental processes across tissues: early embryogenesis (primitive streak formation), brain and pituitary development, peripheral nervous system neuron development, and differentiation of blood and spleen lineages. There is also a recurring theme of transcriptional regulation by RNA polymerase II and immune responsiveness (lipopolysaccharide). Taken together, this cluster seems to reflect general developmental differentiation programs rather than a single pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0021983","count":5},{"id":"GO:0032496","count":5},{"id":"GO:0006366","count":5},{"id":"GO:0090009","count":5}]},{"hash":"2050287747120929481","title":"Developmental Signaling and Immune Activation","description":"The cluster shows strong representation of broad development-related processes (nervous system, kidney, heart development, angiogenesis) and developmental signaling pathways (ROBO/roundabout and SHH/smoothened), together with immune signaling (T cell receptor signaling, T cell costimulation) and proliferation/migration. This suggests a cohesive theme around developmental signaling that also interfaces with immune activation and tissue growth.","confidence":"High","size":19,"edges":111,"triangles":296,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":12},{"id":"GO:0050852","count":12},{"id":"GO:0001822","count":11},{"id":"GO:0035385","count":11},{"id":"GO:0007224","count":11}]},{"hash":"1172171624730973985","title":"Cardiovascular development and ECM remodeling","description":"The cluster is strongly enriched for cell adhesion (heterophilic and cell-matrix), migration and sprouting angiogenesis, and explicit heart development terms (endocardial cell differentiation, endocardial cushion development), plus hyaluronan biosynthesis. Together these point to proteins involved in heart morphogenesis and extracellular matrix remodeling, with adhesion and angiogenic processes at the core. Immune terms (complement activation, IL-4 production) may reflect context-specific signaling but are less central to the primary theme.","confidence":"Medium","size":19,"edges":19,"triangles":1,"max_degree":18,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007157","count":18},{"id":"GO:0007160","count":17},{"id":"GO:0090050","count":17},{"id":"GO:0001867","count":16},{"id":"GO:0006590","count":15}]},{"hash":"866821034993303011","title":"Embryonic Development and Organogenesis","description":"The top GO terms point to a broad spectrum of embryonic development and tissue/organ formation processes (pancreatic cell development, endocrine system development, left-right patterning, placental development, cartilage morphogenesis, inner ear development, primitive streak formation, endocardial cushion and trophoblast differentiation). This suggests the cluster groups proteins involved in general embryogenesis and organogenesis rather than a single specific pathway, hence a label centered on developmental patterning and organ formation. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"1183978536827423284","title":"Neuronal development and synapse formation","description":"The top GO terms point to neural development and wiring: axonogenesis, axonal fasciculation, myelination in the peripheral nervous system, and positive regulation of synapse assembly, plus the involvement in short-term memory, all of which suggest roles in neuronal growth, guidance, and synaptic maturation. While there are outliers related to angiogenesis/VEGF signaling and a couple of unrelated terms, they do not dominate the cluster\u2019s function, so a label focused on neural development and synapse formation fits best.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007614","count":2},{"id":"GO:0043129","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0006469","count":2}]},{"hash":"1284941852656199742","title":"Cell Adhesion and ECM Signaling","description":"This cluster centers on processes tied to cell adhesion and extracellular matrix interactions (cell adhesion; glomerular basement membrane development; melanocyte adhesion) and cytoskeletal/ signaling dynamics (regulation of Rho protein signal transduction) that shape tissue architecture and connectivity. While some terms (spermatid development, voltage-gated sodium channel clustering, dendritic spine regulation) are more divergent, the dominant theme appears to be adhesion-mediated organization and remodeling of cells and matrix across tissues. Confidence: Medium","confidence":"","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045162","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0006910","count":5},{"id":"GO:0006958","count":5},{"id":"GO:0035023","count":5}]},{"hash":"1293149020586436444","title":"Lipid mediator and steroid biosynthesis","description":"The cluster shows strong enrichment for lipid-derived mediators (prostaglandin and oxylipin biosynthesis) and steroid hormone production (aldosterone), plus related hormone signaling and physiological responses (response to vitamin D, regulation of blood volume by aldosterone, mammary gland development). These together point to a cohesive theme of lipid mediator and steroid hormone biosynthesis and signaling, despite a few outlier terms. ","confidence":"Medium","size":19,"edges":53,"triangles":40,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":19},{"id":"GO:0033076","count":18},{"id":"GO:0031408","count":18},{"id":"GO:0010164","count":18},{"id":"GO:0032342","count":18}]},{"hash":"687294069502089197","title":"Proviral DNA integration and latency","description":"The top GO terms point strongly to viral life-cycle processes: DNA recombination and DNA integration, RNA-templated DNA synthesis, DNA replication, and the established proviral latency and viral entry into the host nucleus, along with host apoptosis activation by symbionts. This combination suggests proteins involved in provirus integration, replication, and latency rather to basic cellular functions. ","confidence":"High","size":19,"edges":164,"triangles":856,"max_degree":18,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":10},{"id":"GO:0015074","count":9},{"id":"GO:0046718","count":9},{"id":"GO:0075713","count":9},{"id":"GO:0039651","count":8}]},{"hash":"1153506515292754696","title":"Calcium-NFAT signaling in neural and cardiac development","description":"This cluster centers on developmental processes (angiogenesis, heart development, neural crest formation, multicellular organism development) and calcium signaling (calcium ion detection, regulation of calcineurin-NFAT signaling). The inclusion of neural-related terms (neurotransmitter secretion, memory) alongside cardiovascular development suggests a shared theme of calcium-dependent developmental signaling pathways, especially NFAT-mediated processes in neural and heart contexts.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007269","count":4},{"id":"GO:0051533","count":4},{"id":"GO:0005513","count":4}]},{"hash":"1259131065284537250","title":"Developmental signaling and tissue morphogenesis","description":"This cluster shows GO terms centered on broad developmental processes and tissue morphogenesis across multiple systems (nervous system, bone ossification, sarcomere organization in muscle, endothelial morphogenesis, etc.) with associated signaling pathways (ERK cascade, Rho signaling). The common theme is developmental regulation of tissue formation rather than a single specific function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0043552","count":4}]},{"hash":"1583378252688021472","title":"Secretory and vesicle trafficking proteins","description":"Top terms indicate insulin secretion, endocytic recycling, intralumenal vesicle formation, and related membrane processes. Although some terms are obsolete or broad (transcription, morphogenesis), the strongest shared theme is membrane trafficking and secretion, implying these proteins participate in secretory vesicle formation and/or vesicle recycling rather than a single specific function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030073","count":2},{"id":"GO:0048820","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0010452","count":2}]},{"hash":"1497231626925771395","title":"Regulation of transcription and signaling","description":"A set of terms centers on gene expression control at multiple levels (DNA-templated transcription, chromatin modification, and post-transcriptional processes such as miRNA-mediated silencing and translational initiation control) plus engagement in signaling pathways (phosphatidylinositol-mediated signaling and Wnt calcium signaling) and receptor internalization. This pattern suggests a cohesive regulatory module governing transcription, translation, and signal transduction that influences cell proliferation and differentiation. Some annotations are obsolete, but they still align with regulatory themes. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0048015","count":2},{"id":"GO:0031623","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0043363","count":1}]},{"hash":"1785165075895388698","title":"DNA repair and telomere maintenance","description":"The top GO terms cluster around DNA repair and telomere biology (mitochondrial DNA repair, single-strand break repair, telomere maintenance via telomerase, localization to telomeric regions) and PARP-related regulation, with additional links to spindle assembly and cellular stress responses (heat shock/unfolded protein response, amyloid-beta response). One term about smooth muscle development seems incidental noise, but the core cluster points to genome maintenance and stress-response processes during cell division. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048745","count":3},{"id":"GO:0032212","count":3},{"id":"GO:1904646","count":2},{"id":"GO:0035080","count":2},{"id":"GO:0043504","count":2}]},{"hash":"1876139285873790184","title":"Adaptive immune differentiation and regulation","description":"The top GO terms are dominated by immune-related processes: pro-T cell differentiation, memory T cell differentiation, Type 2 immune response, regulation of mast cell cytokine production, and regulation of IgE isotype switching. This points to a cohesive theme of immune cell development and modulation, with other terms likely reflecting broader differentiation annotations rather than a core function of the cluster. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":13},{"id":"GO:0042787","count":13},{"id":"GO:0048294","count":11},{"id":"GO:2000176","count":11},{"id":"GO:0042092","count":11}]},{"hash":"1385907981758089855","title":"Unknown","description":"The top GO terms cover pain sensing, synaptic plasticity, spindle assembly, telomere maintenance, fat cell differentiation, heart morphogenesis, and salicylic acid signaling, a broad, heterogeneous set with no single shared function. Therefore label Unknown with no confidence.","confidence":"","size":19,"edges":35,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":13},{"id":"GO:0032088","count":13},{"id":"GO:0050968","count":12},{"id":"GO:1900383","count":12},{"id":"GO:0051225","count":12}]},{"hash":"2101751233865479156","title":"Steroid Hormone and Vitamin D Metabolism","description":"The cluster features multiple GO terms tied to steroid hormone biosynthesis and regulation (aldosterone-related), renal control of blood volume, and vitamin D response/catabolism, with supporting lipid signaling and oxidative processes (oxylipin biosynthesis, demethylation). This combination suggests a cohesive theme around steroid hormone pathways and vitamin D\u2013related metabolism, making the label representative. ","confidence":"Medium","size":19,"edges":71,"triangles":99,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":19},{"id":"GO:0031408","count":19},{"id":"GO:0010164","count":19},{"id":"GO:0032342","count":19},{"id":"GO:0002017","count":19}]},{"hash":"1104589600693661914","title":"Sensory Development and Ion Signaling","description":"These proteins are enriched for GO terms related to development (multicellular organism, skin, vestibular nucleus) and sensory perception (pain, chemical stimulus detection, temperature response), plus ion transport/electrophysiology (potassium export, cardiac action potential). The combination suggests a cluster involved in the development of sensory systems and signaling that depends on ionic gradients, though the terms are somewhat diverse. Medium","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0043588","count":8},{"id":"GO:0071502","count":7},{"id":"GO:0097623","count":7}]},{"hash":"1728294445475387855","title":"Transmembrane ion and nutrient transporters","description":"The cluster is dominated by GO terms for transmembrane transport across various ions (potassium, sodium, phosphate) and nutrients (galactose, nitrate/nitrite), with an additional term related to neurotransmitter loading into synaptic vesicles and xenobiotic transport. This pattern points to a cohesive group of membrane transport proteins handling ion and metabolite movement, with a peripheral link to neurotransmitter-related transport. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0035725","count":7},{"id":"GO:0098700","count":6},{"id":"GO:0006004","count":6}]},{"hash":"749515338989707251","title":"Organogenesis and Tissue Patterning","description":"This cluster centers on organismal development and tissue morphogenesis, with strong signals for heart development, angiogenesis, left-right pattern formation, and organ-specific lineages (pancreas, kidney, placenta), plus related patterning and signaling regulation terms, indicating a cohesive theme of developmental programs guiding organogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0072205","count":4},{"id":"GO:0042994","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0007275","count":4}]},{"hash":"58965225972530805","title":"Cardiac Muscle Function and Ion Transport","description":"This cluster centers on GO terms tied to cardiac muscle contraction, ventricular morphogenesis, muscle fiber type transitions, and regulation of muscle filament sliding\u2014together pointing to cardiac muscle physiology and contraction mechanics. The accompanying calcium and chloride transmembrane transport terms reinforce the theme of excitation-contraction coupling via ion handling. A few terms related to memory or sound perception appear peripheral to this core, so the dominant signal is cardiac muscle function and ion transport.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035774","count":2},{"id":"GO:0070588","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0007614","count":2},{"id":"GO:0032972","count":2}]},{"hash":"1787413236186470049","title":"Embryonic development and organogenesis","description":"The GO terms point strongly to developmental processes: left/right pattern formation, various organ and tissue developments (pancreatic endocrine development, placenta-related differentiation, cartilage morphogenesis, roof of the mouth), and EMT events in heart structures. While there is a minor note about hydrogen peroxide response, the dominant signal is embryonic patterning and organogenesis, suggesting these proteins collectively participate in early tissue formation and organ development rather than a single pathway. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060707","count":7}]},{"hash":"2138870161630753836","title":"Cardiac Calcium Signaling and Related Pathways","description":"The top GO terms center on calcium-dependent signaling and cardiac function (regulation of cardiac muscle contraction via calcium release and SA node action potential), complemented by associated signaling networks (Wnt/calcium, GPCR signaling, NF-kappaB, intracellular signaling) and broader processes like cell migration and apoptosis. This suggests a cluster of proteins involved in calcium-mediated signal transduction with cardiac relevance and interconnected signaling pathways, though some terms are generic or obsolete. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0007223","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0010881","count":3},{"id":"GO:1902042","count":3}]},{"hash":"1487738538884004066","title":"Cartilage, ear, and vascular morphogenesis","description":"The top GO terms point to development and remodeling across cartilage (cartilage development, chondrocyte proliferation), auditory structures (sensory perception of sound, labyrinthine-related vascular development), and cardiovascular tissues (endothelial chemotaxis, heart morphogenesis, wound healing). Integrin-mediated adhesion and related processes further support tissue morphogenesis and ECM interactions. Together these suggest a cohesive theme of morphogenesis spanning cartilage, ear, and vascular systems, justifying this label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0061036","count":2},{"id":"GO:1902731","count":2},{"id":"GO:0044319","count":2},{"id":"GO:0046676","count":2}]},{"hash":"2279656627431625633","title":"Cell Signaling and Differentiation","description":"The terms point to receptor tyrosine kinase\u2013mediated signaling (AKT activation, RTK activation) and various differentiation contexts (brown fat cells, mechanoreceptors, taste buds), as well as an extrinsic apoptotic signaling pathway. This suggests a general cluster around signal transduction coupled with differentiation and survival processes, rather than a single specific pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032148","count":2},{"id":"GO:0050873","count":1},{"id":"GO:0040015","count":1},{"id":"GO:0048235","count":1},{"id":"GO:0043524","count":1}]},{"hash":"932542464183757148","title":"Endothelial angiogenesis and vascular regulation","description":"The cluster's top GO terms converge on vascular biology: blood coagulation, cell-matrix adhesion, endothelial cell activation, and endothelial proliferation in sprouting angiogenesis, along with both positive and negative regulation of BMP signaling. This points to a cohesive theme of vascular development and endothelial signaling. A few terms (adult locomotory behavior, L-arabinose metabolism, otolith tethering) are more peripheral or reflect multifunctional genes, but do not override the dominant vascular pattern.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0002043","count":4},{"id":"GO:0030514","count":4},{"id":"GO:0030513","count":4}]},{"hash":"1521519057107100273","title":"Embryogenesis, patterning, and organogenesis","description":"These proteins are linked to broad developmental processes, such as EMT in heart cushion formation, left-right patterning, pancreatic cell development, trophoblast differentiation, cartilage morphogenesis, and endocrine system development. The presence of intracellular signaling terms and positive regulation of the ERK/MAPK cascade suggests these proteins participate in coordinating differentiation and morphogenesis signals. The ribosomal subunit export term points to active protein synthesis during development. Overall, the cluster appears to reflect embryonic development and tissue morphogenesis programs rather than a single tissue-specific function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0060806","count":5}]},{"hash":"1464492873286322996","title":"Embryonic development and organ morphogenesis","description":"The proteins are linked to GO terms covering embryogenesis, left-right axis patterning, endocrine system development, heart cushion EMT, placenta development, mesoderm formation, and cartilage morphogenesis, indicating a shared role in developmental processes and organ formation across multiple tissues (pancreas, heart, placenta, skeletal). ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0060972","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060707","count":5}]},{"hash":"2115905130975257033","title":"Axon guidance and myelination","description":"The top GO terms cluster around neural development processes: axonal fasciculation, semaphorin-plexin signaling in axon guidance, sympathetic neuron projection extension, olfactory bulb development, and myelination, along with related synapse assembly and ERK/MAPK signaling. These collectively point to neural connectivity and maturation, justifying a label focused on axon guidance and myelination.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0042552","count":2},{"id":"GO:0035584","count":2},{"id":"GO:1902287","count":2},{"id":"GO:0032474","count":2}]},{"hash":"589417086388537169","title":"Mitotic control and developmental gene regulation","description":"This cluster centers on mitotic cycle control (mitotic cell cycle, G2/M, re-entry into mitotic cell cycle) and transcriptional regulation, with strong signals of apoptosis and development in tissues such as nervous system, heart, and skeletal muscle, plus a touch of B cell signaling. The combination suggests proteins coordinating cell division with developmental programs and transcriptional control.","confidence":"Medium","size":18,"edges":36,"triangles":52,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":10},{"id":"GO:0007601","count":10},{"id":"GO:0000086","count":9},{"id":"GO:0043065","count":9},{"id":"GO:0006351","count":9}]},{"hash":"2127611087426675599","title":"Axon Guidance and Neural Crest Migration","description":"Based on the top GO terms, the proteins cluster around neuronal pathfinding and neural crest\u2013derived cell migration. Terms include commissural neuron axon guidance, sensory neuron axon guidance, retinal ganglion cell axon guidance, vestibulocochlear nerve organization, otic placode development, dorsal root ganglion morphogenesis, and sympathetic neuron projection extension, as well as migration-related processes like cell migration involved in sprouting angiogenesis. This combination points to a coherent theme of neural development focused on axon guidance and neural crest\u2013driven morphogenesis.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002042","count":3},{"id":"GO:0036486","count":2},{"id":"GO:0071679","count":2},{"id":"GO:1902336","count":2},{"id":"GO:0097374","count":2}]},{"hash":"1915252743015435980","title":"Innate immune activation and complement pathway","description":"The top GO terms are dominated by innate immune functions: complement activation via the lectin pathway, phagocytosis recognition, leukocyte tethering, and basophil activation, plus a response to fungal origin. While some kidney/lymph development terms appear, they are far less represented, making innate immune activity the best unifying theme for this cluster.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":16},{"id":"GO:0071226","count":14},{"id":"GO:0072177","count":12},{"id":"GO:0006910","count":12},{"id":"GO:0072218","count":12}]},{"hash":"64450994144588377","title":"Vertebrate organ and neural development","description":"The top GO terms cluster around organismal development with specific emphasis on skeletal and heart development and neural tube closure, plus synapse assembly, indicating vertebrate organogenesis and neural patterning as the prevailing theme. Additional terms related to prostaglandin signaling and innate immune response suggest inflammatory signaling can accompany development but do not redefine the main function of the cluster.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0001501","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0071380","count":3}]},{"hash":"1953665833353706820","title":"Membrane lipid signaling and cadherin adhesion","description":"This cluster\u2019s top terms emphasize membrane-associated processes: cadherin-mediated cell-cell adhesion, lipid localization, PKC signaling, and cardiolipin metabolism in mitochondria, along with regulation of mitochondrial DNA replication. Together, they point to a theme of membrane-localized lipid signaling linked to mitochondrial lipid metabolism and cell adhesion, hence a label focused on membrane lipid signaling and cadherin adhesion.","confidence":"Medium","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:2000049","count":8},{"id":"GO:0070584","count":8},{"id":"GO:0007588","count":8},{"id":"GO:0010876","count":8},{"id":"GO:0090297","count":8}]},{"hash":"42900853877476564","title":"Microtubule-based spindle assembly and alignment","description":"Dominated by microtubule-related mitotic/meiotic spindle processes (spindle assembly, minus-end microtubule sliding, chromosome alignment, spindle orientation). Some terms also touch cytoskeletal roles in chloroplast movement and development, but the core theme is microtubule-driven spindle dynamics.","confidence":"High","size":18,"edges":120,"triangles":445,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0021685","count":13},{"id":"GO:0033624","count":13},{"id":"GO:0099607","count":13},{"id":"GO:0031534","count":13},{"id":"GO:0051296","count":13}]},{"hash":"1397382454206789609","title":"Unknown","description":"The top GO terms span diverse processes from nuclear DNA metabolism (DNA-templated transcription, DNA replication, UV-damage repair) to cytosolic proteostasis (stress granule disassembly, inclusion body assembly, protein homooligomerization, misfolded protein catabolic process), vesicle formation, mitochondrial membrane insertion, and even development. There is no single dominant theme uniting these terms, and the lack of edges suggests a heterogeneous or artifacts-driven cluster. Therefore, Unknown with None confidence. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035617","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0071712","count":6},{"id":"GO:0090261","count":6}]},{"hash":"338651495915351434","title":"Developmental Signaling and Actin Dynamics","description":"The cluster\u2019s top GO terms converge on tissue development (telencephalon development, multicellular organism development, myoblast fusion) and cytoskeletal organization (actin cytoskeleton reorganization, positive regulation of actin filament binding, cell polarity). Regulatory signaling (JNK activity, erythropoietin signaling) and translation upregulation during growth further suggest coordinated signaling and cytoskeletal remodeling during development. Overall, these proteins appear tied to developmental processes that rely on actin dynamics and signaling networks.","confidence":"Medium","size":18,"edges":94,"triangles":213,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":18},{"id":"GO:0007520","count":18},{"id":"GO:0021537","count":18},{"id":"GO:0045727","count":18},{"id":"GO:0031532","count":18}]},{"hash":"316434314487820870","title":"Ribosome and mitochondrial translation","description":"These terms cluster around protein synthesis and ribosome biogenesis in both cytosol and mitochondria. The presence of mitochondrial translation (GO:0032543) and cytoplasmic translation (GO:0002181), plus ribosomal small subunit assembly (GO:0000028) and rRNA processing (GO:0000447), points to proteins involved in assembling and translating ribosomes across compartments. Additional mitochondrial maintenance signals (e.g., NADH dehydrogenase-related and calcium homeostasis terms) suggest complementary roles tied to mitochondrial function. ","confidence":"High","size":18,"edges":73,"triangles":221,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006120","count":2},{"id":"GO:0036444","count":2},{"id":"GO:0051560","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1810949199835803331","title":"Immune response and chemotaxis","description":"This cluster is driven by immune-related GO terms, notably innate immune response, cellular response to lipopolysaccharide, and T cell homeostasis, alongside chemotaxis, which points to immune cell migration and signaling. While there are also metabolic/transport terms (potassium transport, glucose metabolism) and development signals present, the immune and migration themes are the strongest cohesive thread tying these proteins together.","confidence":"High","size":18,"edges":29,"triangles":22,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0043029","count":3},{"id":"GO:0006935","count":2}]},{"hash":"1206372801559205036","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for ribosome biogenesis, ribosomal subunit biogenesis, and translation, including rRNA processing and SSU-rRNA maturation, indicating a cohesive group of proteins involved in ribosome assembly and protein synthesis. The additional RNA-processing and splicing-related terms suggest broader involvement in RNA maturation and quality control linked to ribosome function. Overall, the theme centers on ribosome production and translation machinery.","confidence":"High","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0006412","count":6},{"id":"GO:0042273","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0006364","count":4}]},{"hash":"1012416352014822342","title":"Tumor Immunity and Complement Activation","description":"Based on the top GO terms, the proteins cluster around immune defense, including defense response to tumor cell, immune response to tumor cell, and classical complement activation. There is also mention of angiogenesis regulation and retinoic acid response, which can relate to immune modulation or tumor microenvironment dynamics, but a few terms (plant-type hypersensitive response, maternal behavior, regulation of mitotic cell cycle) appear less directly connected. Overall, the main signal supports tumor immunity and complement activation, with some noise.","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":3},{"id":"GO:2000009","count":2},{"id":"GO:0001970","count":2},{"id":"GO:0071300","count":2},{"id":"GO:0009626","count":2}]},{"hash":"2092104983301917532","title":"Immune and cellular stress signaling","description":"This cluster centers on immune and stress-response processes, with GO terms for NOD1/NOD2 signaling, T cell costimulation, and responses to ischemia, mechanical stimuli, extrinsic apoptotic signaling, and TGF-beta. Pigmentation-related terms are present but less central to the main theme, so the label emphasizes innate/adaptive immune signaling coupled with cellular stress responses.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001238","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0070427","count":2},{"id":"GO:0002931","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1311745444612145027","title":"Developmental differentiation across tissues","description":"The cluster\u2019s top GO terms center on tissue development and differentiation across diverse lineages (melanocyte differentiation, cardiac neural crest\u2013driven heart morphogenesis, vestibular nucleus development, various endocrine and bone differentiation, stomatal development in plants) and include transcription by RNA polymerase II, suggesting a shared theme of gene regulation guiding lineage specification. The cross-species mix of terms makes a highly specific function unlikely, but the common thread is developmental differentiation rather than a single pathway.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":18},{"id":"GO:0030318","count":15},{"id":"GO:0003253","count":15},{"id":"GO:0021750","count":15},{"id":"GO:0003062","count":15}]},{"hash":"76596891311500810","title":"ECM organization in skin and cartilage","description":"Rationale: The top GO terms cluster around extracellular matrix processes and tissue development\u2014collagen fibril organization, skin development, and cartilage condensation\u2014indicating a function in ECM assembly and morphogenesis. Cell adhesion supports a structural role, while negative regulation of angiogenesis fits tissue patterning. The complement activation terms are less central and may reflect ECM-associated immune interactions rather than core activity. Overall, the cluster appears to represent ECM remodeling and skin/cartilage development.","confidence":"High","size":18,"edges":5,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":5},{"id":"GO:0043588","count":4},{"id":"GO:0016525","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0007155","count":3}]},{"hash":"1990464371003253509","title":"Cardiac development signaling and cell cycle regulators","description":"Based on the top GO terms, the cluster is strongly tied to heart development and cardiac morphogenesis (cardiac right atrium morphogenesis, venous endothelial differentiation, Notch signaling in heart field), with additional signals related to cell cycle regulation (spindle assembly, CDK inhibition). Some terms (sensory perception, synaptic plasticity) may be incidental or reflect broader signaling contexts. Overall, the dominant theme is cardiac development signaling with supporting cell-cycle regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003213","count":10},{"id":"GO:0060843","count":10},{"id":"GO:0003270","count":10},{"id":"GO:0050968","count":9},{"id":"GO:1900383","count":9}]},{"hash":"1006410700392310842","title":"Axon guidance and myelination","description":"This cluster is dominated by GO terms related to nervous system development, especially peripheral nervous system development, ROBO (Roundabout) signaling for axon guidance, and myelination, with supportive terms on cell adhesion and migration. While immune signaling terms appear, the strongest theme is neural development and myelination, so the name reflects the core function of the proteins.","confidence":"High","size":18,"edges":134,"triangles":565,"max_degree":17,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035385","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0050852","count":12},{"id":"GO:0008284","count":11},{"id":"GO:1904237","count":11}]},{"hash":"1579337513716499342","title":"Neurodevelopment and organogenesis","description":"The cluster\u2019s top GO terms center on differentiation and cell fate specification across neural lineages (motor neurons, GABAergic interneurons, oligodendrocytes, floor plate, subpallium) and extend to broader organ development (bronchioles, lung vasculature, endocrine pancreas). This points to a common theme of developmental programming and tissue-specific differentiation, justifying a neurodevelopmental/organogenesis label.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0021520","count":9},{"id":"GO:0021892","count":9},{"id":"GO:0021530","count":9},{"id":"GO:0060435","count":9}]},{"hash":"1286274214404218267","title":"Embryonic organogenesis and tissue differentiation","description":"The GO terms cluster around embryonic morphogenesis and organ development across multiple tissues (lung, eye, floor plate, somite, bone, retina). This suggests a broad developmental program driving tissue specification and organogenesis, with RNA polymerase II\u2013mediated transcription underpinning these processes.","confidence":"High","size":18,"edges":126,"triangles":477,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0060441","count":5},{"id":"GO:0043010","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0033504","count":5}]},{"hash":"2083643894858965132","title":"Embryonic endocrine and cardiac development with transcription regulation","description":"This cluster\u2019s top GO terms center on endocrine system development and pancreatic beta-cell development, left-right pattern formation, and endocardial EMT, plus regulation of transcription by RNA polymerase II. Together these point to embryonic organogenesis and gene expression control as a core theme, with additional, less central terms related to digestion and innate immune responses that may reflect broader annotations.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0032496","count":6},{"id":"GO:0045944","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0006958","count":6}]},{"hash":"136849881094953473","title":"Membrane trafficking and muscle development","description":"The cluster contains terms tied to membrane dynamics (plasma membrane repair, intracellular protein transport, PI dephosphorylation regulation) and vesicle processes (synaptic vesicle maturation, ribophagy), plus a muscle-specific process (myoblast fusion). Angiogenesis and its negative regulation imply a vascular context, so the shared theme appears to be membrane remodeling and trafficking in muscle differentiation with relevance to vascular remodeling. This link is plausible but not uniformly strong across all terms, so a Medium confidence is appropriate.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0016188","count":3},{"id":"GO:0006886","count":3},{"id":"GO:0001778","count":3},{"id":"GO:0001525","count":3}]},{"hash":"1764989391602510824","title":"Axon Guidance and Paranodal Assembly","description":"Proteins in this cluster are heavily tied to neural development and axon pathfinding, with GO terms emphasizing neuron projection guidance (sympathetic and branchiomotor), nerve structure organization (trigeminal nerve, retina layer formation), and localization to paranode/juxtaparanode regions along with semaphorin-plexin signaling. This suggests a cohesive role in axon guidance and paranodal assembly.","confidence":"High","size":18,"edges":39,"triangles":11,"max_degree":11,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0002175","count":13},{"id":"GO:0097490","count":13},{"id":"GO:0021785","count":13},{"id":"GO:0071205","count":13},{"id":"GO:1902287","count":13}]},{"hash":"1349151271004158427","title":"Unknown","description":"The top GO terms span disparate processes\u2014from transcriptional regulation by RNA polymerase II to development (midbrain, heart), digestion, coagulation, complement activation, collagen breakdown, and fertilization\u2014without a clear shared function or pathway tying the majority of proteins. With no connections indicated (no edges), there isn\u2019t a coherent theme to label, so Unknown is most appropriate. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0045944","count":6},{"id":"GO:0007586","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0007596","count":4}]},{"hash":"1298973967887470135","title":"Embryonic organogenesis and morphogenesis","description":"The terms cluster around embryonic development and formation of multiple organs/tissues (pancreas, placenta, cartilage, inner ear, palate) and patterning, indicating a shared theme of organogenesis and morphogenesis, with several related regulatory processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"601478058945484093","title":"Cerebellar synaptic signaling (glycinergic/glutamatergic)","description":"These proteins show enrichment for synaptic transmission terms, including glycinergic and glutamatergic signaling, receptor clustering, and excitatory postsynaptic potentials, along with a note on cerebellar granule cell differentiation. The combination suggests a module centered on cerebellar synaptic communication, involving both glycine and glutamate pathways, with supporting transport and receptor organization functions.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0008542","count":2}]},{"hash":"1873044411234512106","title":"Neurovascular development and synaptic signaling","description":"This cluster centers on both vascular and neural development: several proteins are linked to angiogenesis and its regulation, while others relate to synapse organization, glutamate secretion, and myelination. Additional signals such as Hedgehog (Smoothened) pathway activity and general GTPase/MAPK signaling support a broader developmental and signaling context, with neural development and neural-vascular interplay as the unifying theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0050808","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0045765","count":3},{"id":"GO:0019933","count":3}]},{"hash":"2242221311109062634","title":"Neural development and cell adhesion","description":"The cluster is dominated by terms related to cell adhesion and neural development, including heterophilic and general cell adhesion, axon guidance via semaphorin-plexin signaling, sympathetic neuron projection extension, and synapse assembly, with supporting signals of morphogenesis. Immune and bone maturation terms are present but appear peripheral to the central theme of neural development and cell-cell adhesion.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":12},{"id":"GO:0006958","count":10},{"id":"GO:0007275","count":9},{"id":"GO:0043931","count":9},{"id":"GO:0051965","count":9}]},{"hash":"1194257651550882931","title":"Biomolecule and xenobiotic metabolism","description":"The top GO terms point to a broad metabolic theme, including bile acid, thyroid hormone, catecholamine, flavonoid, and xenobiotic metabolism, as well as glycosaminoglycan biosynthesis; together they suggest proteins involved in diverse biomolecule processing rather than a single specific pathway.","confidence":"Medium","size":18,"edges":129,"triangles":508,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0030573","count":17},{"id":"GO:0006044","count":17},{"id":"GO:0015015","count":17},{"id":"GO:0042403","count":17},{"id":"GO:0030205","count":17}]},{"hash":"610407010754010549","title":"Developmental cell adhesion and morphogenesis signaling","description":"The cluster shows strong representation of cell-cell adhesion terms (homophilic/heterophilic adhesion) and receptor signaling activity, plus several GO terms tied to tissue morphogenesis and differentiation (lung branching, muscle satellite cell differentiation, gastrulation epiboly, axon guidance, brown fat differentiation). This pattern suggests a cohesive theme of developmental signaling coordinating cell adhesion and tissue remodeling during development.","confidence":"Medium","size":18,"edges":64,"triangles":126,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007213","count":6},{"id":"GO:0043113","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0007156","count":5},{"id":"GO:0060488","count":5}]},{"hash":"23349410767709075","title":"Innate Immunity and Inflammatory Cell Death","description":"Top GO terms center on innate immune response, inflammatory response, and programmed cell death (apoptosis and pyroptosis), with protein ubiquitination linking signaling. This suggests the cluster collectively participates in innate immune signaling and inflammatory cell death pathways, despite some secondary terms hinting at broader stress responses. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":16},{"id":"GO:0090307","count":15},{"id":"GO:0006915","count":15},{"id":"GO:1990001","count":15},{"id":"GO:0070269","count":15}]},{"hash":"1790263235082406221","title":"T Cell Differentiation and Type 2 Immunity Regulation","description":"The top GO terms include several immune-related processes: positive regulation of pro-T cell differentiation, regulation of memory T cell differentiation, type 2 immune response, negative regulation of mast cell cytokine production, and negative regulation of isotype switching to IgE. These point to a cohesive theme of adaptive immune signaling and T cell regulation, with both stimulatory and inhibitory controls, and a secondary signal of ubiquitin-dependent protein catabolic process that is common to many proteins. Some terms (gravitropism, sarcomere organization, distal tubule morphogenesis, nervous system development) are less connected and may reflect broader, cross-species annotations or background noise.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0048294","count":12},{"id":"GO:2000176","count":12},{"id":"GO:0042092","count":12},{"id":"GO:0009958","count":12}]},{"hash":"924466429555608143","title":"Embryonic patterning and organogenesis","description":"These terms cluster around embryonic development and tissue morphogenesis, including left-right pattern formation, endocrine system development, cartilage morphogenesis, placental development, and heart cushion EMT, indicating a cohesive program of developmental patterning and organ formation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":14},{"id":"GO:0003323","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0060707","count":14}]},{"hash":"480157372971272907","title":"Endocrine development and hormone biosynthesis","description":"This cluster is dominated by terms related to endocrine/gland development (uterus and mammary gland development) and hormone-related processes (aldosterone biosynthesis, renal aldosterone regulation, vitamin D response), suggesting an endocrine development theme. A few terms about oxylipin and isoquinoline alkaloid metabolism appear less directly connected.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":17},{"id":"GO:0033076","count":15},{"id":"GO:0031408","count":15},{"id":"GO:0010164","count":15},{"id":"GO:0032342","count":15}]},{"hash":"877910811678813790","title":"Steroid and eicosanoid hormone biosynthesis","description":"Prostaglandin/oxylipin and aldosterone biosynthesis terms dominate the top GO terms, with related hormone response processes (vitamin D signaling, mammary development, renal aldosterone effects). This suggests a cohesive theme around lipid-derived hormone production and signaling, rather than a single discrete function.","confidence":"High","size":18,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":18},{"id":"GO:0033076","count":17},{"id":"GO:0031408","count":17},{"id":"GO:0010164","count":17},{"id":"GO:0032342","count":17}]},{"hash":"1114914748148852917","title":"Neuronal signaling and behavior regulation","description":"The GO terms cluster around neuronal communication and behavior: neurotransmitter signaling (acetylcholine, GABA, serotonin), calcium-dependent excitability, reflex/startle and inhibitory control of nerve impulses, sleep/wake circadian regulation, learning (taste aversion), walking behavior, and vestibulocochlear nerve development. This pattern suggests a cohesive theme of neural signaling networks that govern rapid responses and behavioral states.","confidence":"High","size":18,"edges":22,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":18},{"id":"GO:0098703","count":18},{"id":"GO:0045188","count":18},{"id":"GO:0051970","count":15},{"id":"GO:0001661","count":15}]},{"hash":"2236837779429927455","title":"Embryonic development and differentiation regulation","description":"The top GO terms cluster around embryogenesis and organ development, including placental and trophoblast differentiation, left-right patterning, endocrine system development, and cartilage morphogenesis. There are also regulatory processes like EMT in cardiac development and spliceosome-mediated mRNA processing, plus apoptosis regulation, all of which support coordinated development. Together, these terms point to a cohesive theme of developmental differentiation and morphogenesis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0000398","count":2}]},{"hash":"1634616030684007032","title":"Cardiac development and mechanosensing","description":"The cluster\u2019s top terms are strongly centered on heart formation (cardiac right atrium morphogenesis; venous endothelial differentiation; Notch signaling in regulatory steps of heart-field progenitors) and the cellular response to mechanical stimulus, pointing to a cohesive theme of heart development with mechanotransduction. Some terms (e.g., pain detection, synaptic plasticity, telomere maintenance) are more peripheral, but the dominant signal is cardiovascular development and mechanical signaling pathways.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003213","count":6},{"id":"GO:0060843","count":6},{"id":"GO:0003270","count":6},{"id":"GO:0071260","count":6},{"id":"GO:0033280","count":6}]},{"hash":"900109820334839195","title":"Cardiac mechano-electrical signaling","description":"The top GO terms cluster around heart-specific functions\u2014SA node cell communication, regulation of SA node action potential, and cellular/mechanical response to stretch\u2014suggesting a theme of how cardiac cells couple mechanical cues to electrical activity, despite some unrelated annotations present. This core seems plausible given the absence of network edges and the prominence of cardiac-related terms.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072660","count":7},{"id":"GO:0002268","count":7},{"id":"GO:0071260","count":7},{"id":"GO:0035994","count":7},{"id":"GO:0086070","count":7}]},{"hash":"615024648536943148","title":"RNA processing and translation machinery","description":"These proteins cluster around RNA metabolism and the machinery that starts protein synthesis, as shown by snRNA processing, nuclear mRNA surveillance, transcription-coupled repair, and the formation/assembly of translation initiation complexes. While there are a few terms related to development and autophagy, the dominant signal is involvement in RNA processing and translation initiation machinery.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016180","count":1},{"id":"GO:0097352","count":1},{"id":"GO:0070196","count":1},{"id":"GO:0071033","count":1},{"id":"GO:0007127","count":1}]},{"hash":"122076752101118818","title":"Unknown","description":"The top GO terms span both telomere maintenance and telomerase-directed processes, plus cardiovascular development and signal transduction (heart development, vasoconstriction, prostaglandin response, GPCR internalization) as well as meiosis-related events (chiasma assembly, heteroduplex formation). The lack of a single cohesive theme across these terms and the absence of edges suggest no unified function for this cluster. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010833","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0045907","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0002031","count":2}]},{"hash":"1206950952001323958","title":"Systemic Stress and Immune Response","description":"These proteins cluster around broad systemic responses to stress, including temperature/thermogenesis and pain signaling, alongside immune and hormonal regulation (IL-1\u03b2 production, dendritic cell differentiation, vasopressin-related blood pressure control, PKA activity, and coagulation). The mix suggests an integrated network of neuroendocrine-immune and hemostatic responses rather than a single, narrow function.","confidence":"Medium","size":18,"edges":14,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0045494","count":14},{"id":"GO:0001992","count":14}]},{"hash":"1901036665983350240","title":"Stress-Induced Inflammatory Signaling","description":"The GO terms point to temperature- and prostaglandin-related stress responses, GPCR signaling, xenobiotic response, and immune processes (neutrophil chemotaxis and TNF regulation), indicating a network of stress- and inflammation-related signaling rather than a single specific pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0010579","count":5},{"id":"GO:0042493","count":5}]},{"hash":"495757241093138308","title":"Thermal-immune-neural signaling","description":"The top GO terms cluster around temperature and thermogenesis, inflammatory and immune processes (inflammation, IL-1\u03b2 production, dendritic cell differentiation), and neuroendocrine regulation (vasopressin affecting blood pressure), with some neural/visual terms (photoreceptor maintenance, visual learning) that may reflect broader sensory/neural involvement. This combination suggests a theme of thermal stress responses interacting with immune and neuroendocrine signaling, rather than a single, cohesive pathway. Therefore, a compact label capturing thermal and immune-neural aspects is appropriate.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0008542","count":7},{"id":"GO:0040015","count":7},{"id":"GO:0006954","count":7}]},{"hash":"1026217558156735029","title":"Skin immune signaling and keratinocyte development","description":"The top terms cluster around innate immune signaling (NF-kappaB, IL-12 response, immunoglobulin-mediated immunity, histamine response) alongside keratinization and hair follicle morphogenesis, suggesting a skin-related theme where immune pathways interact with epidermal differentiation. Although there are broad terms like miRNA processing and multicellular development, the immune and skin differentiation cues appear most representative of the cluster's function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007249","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0071420","count":2},{"id":"GO:0035196","count":2},{"id":"GO:0031424","count":2}]},{"hash":"658349516812019742","title":"Vascular development and bone formation with coagulation","description":"These proteins cluster around extracellular matrix interactions and tissue remodeling during development, showing links to cell-substrate adhesion, ECM localization, angiogenesis regulation, osteoblast differentiation and bone trabecula formation, as well as coagulation and complement pathways. The convergence of vascular/heart development signals with bone formation and coagulation suggests a coordinated vascular-bone remodeling theme. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0016525","count":4},{"id":"GO:0003281","count":4},{"id":"GO:0031639","count":3}]},{"hash":"2189980959275270422","title":"Embryonic development and placental morphogenesis","description":"Most terms describe developmental processes\u2014left/right patterning, pancreatic cell and trophoblast/placental differentiation, cartilage morphogenesis, and EMT in heart cushion formation\u2014indicating a cluster focused on embryogenesis and tissue morphogenesis. A few terms (complement activation, pathway signaling regulation) are less central but do not override the dominant theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060536","count":6}]},{"hash":"1739046845748869446","title":"Embryonic patterning and organogenesis","description":"The top GO terms cluster around development and morphogenesis across multiple tissues\u2014pancreatic and endocrine development, placenta/trophoblast differentiation, cartilage morphogenesis, and EMT in heart cushion formation\u2014along with left/right pattern formation. This points to a common theme of embryonic tissue differentiation and organ formation, with some ancillary processes like cell cycle and mechanosensing that support developmental programs.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3}]},{"hash":"859417620765486952","title":"Developmental Signaling and Morphogenesis","description":"This cluster's top GO terms center on development-related processes (axon guidance, neuron development, lens morphogenesis) and broad signaling pathways (ERK cascade, VEGF signaling, B cell receptor signaling), suggesting proteins involved in developmental signaling and tissue morphogenesis across different tissues rather than a single specialized function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0038033","count":2}]},{"hash":"1312396071149433606","title":"Skin development and collagen/ECM signaling","description":"The proteins cluster around skin morphogenesis, collagen-related processes (including cuticle development and ECM signaling), and collagen-activated signaling pathways, pointing to an epidermal/dermal extracellular matrix development program. A few terms like visual perception or aldosterone secretion appear as outliers but do not define the core theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":2},{"id":"GO:0007601","count":2},{"id":"GO:2000860","count":1},{"id":"GO:0045112","count":1},{"id":"GO:0033034","count":1}]},{"hash":"1487939061695626539","title":"Neural development and synapse formation","description":"This cluster is dominated by GO terms tied to nervous system development and connectivity: myelination, axonogenesis, axonal fasciculation, and positive regulation of synapse assembly. Otolith morphogenesis also aligns with sensory-neural development, while ubiquitination and innate immune terms appear less central. Overall, the neural development/synaptic assembly theme best explains the shared functions among the proteins. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0032474","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0071260","count":3}]},{"hash":"1225009797207678692","title":"Unknown","description":"The annotated GO terms cover several unrelated areas (Rho signaling, apoptosis, TGF-beta response, heart development, synaptic plasticity, adaptive immunity, actin capping, IP3/PI signaling, lipid catabolism). Because there isn't a unifying biological process or tissue context tying these terms together, the proteins in this cluster do not appear to share a single coherent function.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0071560","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0060291","count":2}]},{"hash":"206106881546994382","title":"Rho-driven cytoskeletal remodeling in morphogenesis","description":"The top GO terms cluster around Rho signaling, actin filament organization, and cell morphogenesis, suggesting proteins mainly participate in cytoskeletal dynamics and shape changes during development. While other terms (lipid metabolism, mitochondrial DNA repair) are present, the core pattern supports a theme of Rho-mediated cytoskeletal remodeling in morphogenesis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007015","count":3},{"id":"GO:0045666","count":2},{"id":"GO:0043504","count":2}]},{"hash":"1256946740247738782","title":"Immune regulation and ECM remodeling","description":"The cluster is enriched for adaptive immune response, IL-6 signaling, and negative regulation of B cell proliferation, along with modulation of extrinsic apoptotic signaling, as well as collagen fibril organization and vascular-related processes (angiogenesis and vasoconstriction). Together, these terms point to immune signaling intertwined with extracellular matrix and vascular remodeling, rather than a single linear pathway. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:1903527","count":2},{"id":"GO:0043553","count":2},{"id":"GO:0045907","count":2},{"id":"GO:1902042","count":2}]},{"hash":"954341733171474253","title":"Immune Regulation: T Cell Differentiation and Type 2 Response","description":"Most of the top GO terms describe immune system regulation, particularly T cell differentiation (pro-T cell and memory T cells) and type 2 responses (IgE isotype switching, mast cell cytokine production). This suggests the proteins cluster around adaptive/innate immune signaling and allergic-type pathways. A few terms relate to non-immune processes (gravitropism, sarcomere organization, distal tubule morphogenesis) and may reflect annotation noise or multifunctional proteins, but the dominant theme is immune regulation. Therefore, the label captures the core function represented by the cluster.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":5},{"id":"GO:0048294","count":4},{"id":"GO:2000176","count":4},{"id":"GO:0042092","count":4},{"id":"GO:0009958","count":4}]},{"hash":"172864212010863527","title":"Embryonic organogenesis and immune signaling","description":"The top GO terms point to developmental processes across multiple organs (mesonephric duct/metanephric tubule development, lymph vessel morphogenesis, cartilage condensation) along with several immune-related events (basophil activation, leukocyte tethering/rolling, C-type lectin receptor signaling, phagocytosis recognition, cellular response to fungal origin). This suggests a cluster of proteins involved in early developmental morphogenesis with concurrent engagement of innate immune signaling or leukocyte interactions. Confidence: Medium","confidence":"","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0072177","count":17},{"id":"GO:0006910","count":17},{"id":"GO:0072218","count":17},{"id":"GO:0050901","count":17},{"id":"GO:0036303","count":17}]},{"hash":"394967025865193593","title":"Innate Immune Recognition and Leukocyte Activation","description":"The top GO terms are dominated by innate immune processes: cellular response to fungal molecules, phagocytosis recognition, leukocyte tethering/rolling, stimulatory C-type lectin receptor signaling, and basophil activation. Some development-related terms appear but seem secondary to the immune-focused terms, likely reflecting pleiotropy or annotation artifacts. Thus the cluster most plausibly represents innate immune recognition and leukocyte activation functions.","confidence":"High","size":17,"edges":130,"triangles":594,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":17},{"id":"GO:0072177","count":16},{"id":"GO:0006910","count":16},{"id":"GO:0072218","count":16},{"id":"GO:0050901","count":16}]},{"hash":"874573448664108155","title":"Unknown","description":"The Top Terms span diverse processes\u2014from ion transport and mitochondrial pyruvate metabolism to acrosome reaction, drug response, and developmental patterning\u2014without a clear shared function or interacting network, so a single cohesive label isn\u2019t supported.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0032425","count":2},{"id":"GO:0007340","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2}]},{"hash":"818985570972410538","title":"Ion and Small-Molecule Transmembrane Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of ions (sodium, potassium), nitrite/nitrate, xenobiotics, and various small molecules, including neurotransmitter loading, indicating a cohesive set of membrane transporter proteins handling diverse substrates.","confidence":"High","size":17,"edges":99,"triangles":269,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0015707","count":5},{"id":"GO:0006855","count":5},{"id":"GO:1900754","count":5}]},{"hash":"1612677071429987067","title":"GPCR signaling and calcium-regulated mucus secretion","description":"The cluster is dominated by GO terms tied to G protein-coupled receptor signaling that activates adenylate cyclase, calcium release into the cytosol, and positive regulation of mucus secretion, suggesting a shared role in calcium-dependent mucosal signaling and secretion. Some terms (heart development, visual perception, spermatid development) are less connected and may reflect broader or tissue-specific expression, so the core theme centers on GPCR-driven calcium signaling and mucus secretion rather than a single developmental process.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0071407","count":3},{"id":"GO:0018298","count":3}]},{"hash":"217135049351056857","title":"mRNA Processing and Splicing Regulation","description":"The cluster is enriched for GO terms such as mRNA polyadenylation, mRNA stabilization, mRNA modification, regulation of alternative mRNA splicing via the spliceosome, and regulatory ncRNA-mediated gene silencing, along with translation reinitiation and small-subunit processome assembly, pointing to a group of proteins involved in post-transcriptional mRNA maturation and regulation of translation.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":4},{"id":"GO:0001825","count":3},{"id":"GO:0031047","count":3},{"id":"GO:1900363","count":3},{"id":"GO:0048255","count":3}]},{"hash":"2203149858134239257","title":"Ubiquitin Modification and Innate Immune Signaling","description":"The dominant terms point to ubiquitin-related processes (deubiquitination, sumoylation, ERAD) and immune signaling (MyD88-dependent TLR and non-canonical NF-kappaB), indicating a cohesive role in regulating signaling through ubiquitin modification. A few other terms (ribosome assembly, DNA methylation, endocytosis, calcium regulation) appear peripheral but may reflect broader cellular coordination.","confidence":"Medium","size":17,"edges":107,"triangles":373,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:0016925","count":8},{"id":"GO:0030433","count":5},{"id":"GO:0034126","count":5},{"id":"GO:0038061","count":5}]},{"hash":"890953306848220156","title":"Heart development and stress-activated signaling regulators","description":"The top GO terms point to processes in heart development and a network of stress- and inflammation-related signaling pathways (NF-\u03baB, JNK, Hippo), along with muscle stretch response and cell fate decisions involving apoptosis and cell cycle regulation. This suggests a cohesive theme of proteins that regulate cardiac development and integrate stress-activated signaling to control growth and survival in heart-related contexts.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035994","count":5},{"id":"GO:0045736","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0046330","count":4}]},{"hash":"1126476213121219101","title":"Cardiovascular development and cell adhesion","description":"The dominant GO terms point to heart/vascular development and cell adhesion: endocardial cell differentiation and endocardial cushion development indicate cardiac tissue formation, while strong enrichment for cell-matrix and heterophilic cell-cell adhesion, plus hyaluronan biosynthesis, suggests ECM-adhesion remodeling. Additional terms for angiogenesis migration and differentiation align with vascular/endocardial lineage specification. Although a lectin complement activation term appears, the core pattern is adhesion-based ECM remodeling tied to cardiac development, supporting the chosen label.","confidence":"High","size":17,"edges":17,"triangles":0,"max_degree":15,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007160","count":16},{"id":"GO:0007157","count":16},{"id":"GO:0001867","count":14},{"id":"GO:0006590","count":14},{"id":"GO:0090050","count":13}]},{"hash":"1469673792176089379","title":"Oxidative Stress and ECM-Immune Signaling","description":"Top GO terms indicate oxidative stress response and redox homeostasis (cellular oxidant detoxification, removal of superoxide radicals, response to alkyl hydroperoxide, hydrogen peroxide-related term) together with extracellular matrix organization and immune-related pathways (natural killer cell cytotoxicity, non-canonical NF-kappaB signaling). This pattern suggests a module where redox balance interfaces with ECM remodeling and immune signaling, potentially coordinating tissue integrity with immune responses under oxidative stress. Some terms (e.g., male gonad development) may be incidental, but the core theme is redox maintenance linked to ECM and immunity.","confidence":"Medium","size":17,"edges":87,"triangles":230,"max_degree":16,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0030198","count":5},{"id":"GO:0098869","count":5},{"id":"GO:0045454","count":5},{"id":"GO:0042158","count":4},{"id":"GO:0033195","count":4}]},{"hash":"1537962042201582985","title":"Developmental organogenesis and tissue remodeling","description":"The GO terms cluster around vertebrate development, including liver and heart development, multicellular organism development, cartilage condensation, and neural differentiation (hair cell differentiation, motor neuron axon guidance), as well as tissue remodeling (endothelial migration). A subset also touches on innate immune responses and apoptotic cell clearance, which can accompany developmental remodeling. Overall, this suggests a group of proteins involved in broad organogenesis and tissue morphogenesis rather than a single, narrow function.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0043277","count":4},{"id":"GO:0043542","count":4}]},{"hash":"2065129968116580383","title":"Unknown","description":"The GO terms are diverse, including nerve maturation, heart development, liver regeneration, receptor-mediated endocytosis, pain response, insulin signaling, and various mitochondrial transport functions. There isn\u2019t a single coherent biological process linking these terms, suggesting the cluster does not map to a specific unified function. ","confidence":"","size":17,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021682","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006898","count":2},{"id":"GO:0048265","count":2},{"id":"GO:0000002","count":2}]},{"hash":"2150290152614560178","title":"Schwann Cell Development and Axon Regeneration Signaling","description":"The cluster is dominated by neural-glial development cues (Schwann cell development, axon regeneration, synapse assembly) and growth-factor\u2013driven signaling (PDGF receptor signaling, PI3K/AKT pathways, receptor clustering). While skeletal development appears among terms, the strongest common theme ties to nerve development, glial support, and remodeling of neural connections via receptor-mediated signaling and phosphorylation.","confidence":"High","size":17,"edges":87,"triangles":175,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001501","count":12},{"id":"GO:0043113","count":12},{"id":"GO:0014044","count":11},{"id":"GO:0071372","count":11},{"id":"GO:0051897","count":11}]},{"hash":"2040802204039080160","title":"Muscle-neuron development and synaptic signaling","description":"These proteins show enrichment for both muscle development (myoblast fusion, heart development) and neural/synaptic terms (Schwann cell development, excitatory postsynaptic potential, long-term potentiation), suggesting a cluster tied to coordinated musculoskeletal and neural development and their synaptic activity. Confidence: Medium","confidence":"","size":17,"edges":19,"triangles":16,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":12},{"id":"GO:0060079","count":12},{"id":"GO:0000278","count":12},{"id":"GO:0007520","count":11},{"id":"GO:0007507","count":11}]},{"hash":"1485470194762869153","title":"Ribosome Biogenesis and Translation","description":"This cluster centers on core ribosome assembly and protein synthesis processes, withGO terms for cytoplasmic translation, tRNA modification, ribosome biogenesis, and ribosomal subunit export from the nucleus. The presence of cell division terms may reflect coordination with the cell cycle, but the dominant signal ties to ribosome assembly and translation machinery.","confidence":"High","size":17,"edges":14,"triangles":0,"max_degree":6,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":8},{"id":"GO:0006400","count":7},{"id":"GO:0000747","count":7},{"id":"GO:0042254","count":7},{"id":"GO:1903833","count":7}]},{"hash":"2150182247192618861","title":"Unknown","description":"The top terms span neural and brain development (brain development, forebrain development, neural tube closure), glial and neuronal apoptosis, immune response (immunoglobulin mediated immune response), and even bone differentiation, with no single coherent function or pathway linking them all. The mixture suggests no clear shared function for the cluster as a whole.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0034349","count":4},{"id":"GO:0051402","count":4},{"id":"GO:0016064","count":4},{"id":"GO:0001649","count":4}]},{"hash":"1612692757957362367","title":"Cerebellar synaptic plasticity and behavior","description":"The terms point to neural signaling and plasticity (long-term synaptic depression, excitatory postsynaptic potential, receptor clustering) with a clear cerebellar development component (cerebellar granule cell differentiation) and several behavior-related phenotypes (social behavior, prepulse inhibition, startle, conditioned taste/ethanol/morphine responses), suggesting a cerebellum-centered theme linking synaptic changes to behavioral outcomes.","confidence":"Medium","size":17,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":5},{"id":"GO:0060292","count":4},{"id":"GO:0021707","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0035176","count":4}]},{"hash":"2299451709769689097","title":"Translation and tRNA modification cluster","description":"This cluster is dominated by translation-related terms (GO:0006412) and tRNA modification pathways (GO:0070329, GO:0032447), including URM1/urmylation and tRNA seleno-modification, which point to a core theme around protein synthesis and tRNA chemistry. Other terms such as redox homeostasis and cell cycle-related processes are present but appear peripheral to the main translation/tRNA modification signal. Therefore, the label reflects a cohesive translation and tRNA modification function group.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0018192","count":2},{"id":"GO:0032447","count":2},{"id":"GO:0070329","count":2},{"id":"GO:0021510","count":2}]},{"hash":"1537027729529351005","title":"Multisystem Signaling Modulation","description":"This cluster appears to group proteins involved in broad signal transduction across multiple systems (immune, nervous, vascular), highlighted by GO terms related to cAMP/PKA signaling, GPCR pathways, and cellular responses that span photoreceptor maintenance, temperature response, inflammation (IL-1\u03b2 production), dendritic cell differentiation, coagulation, and pain sensitization. The varied tissue contexts suggest a general theme of signaling modulation rather than a single, tissue-specific process.","confidence":"Medium","size":17,"edges":81,"triangles":181,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":17},{"id":"GO:0001992","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0032651","count":17},{"id":"GO:0097029","count":17}]},{"hash":"334978385130082487","title":"Spliceosome-Regulated mRNA Processing","description":"Most enriched terms center on spliceosome-mediated splicing regulation and broader mRNA processing (splicing, mRNA stabilization, preinitiation complex formation). Although a development term appears, the dominant theme is post-transcriptional mRNA maturation and its regulation by spliceosome components, including ncRNA-mediated silencing.  ","confidence":"High","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":14},{"id":"GO:0031047","count":14},{"id":"GO:0006378","count":11},{"id":"GO:0001731","count":10},{"id":"GO:0001825","count":9}]},{"hash":"539088672288715310","title":"Mitochondrial energy and lipid biosynthesis","description":"This cluster is dominated by terms related to mitochondrial function (respirasome assembly, complex IV assembly, cytochrome c release regulation) and lipid metabolism (unsaturated/monounsaturated fatty acid biosynthesis, sterol regulation), with an ER unfolded protein response hinting at ER-mitochondrial lipid homeostasis. Taken together, it points to a module tying mitochondrial energy production to lipid biosynthesis and membrane regulation, possibly in a fungal context given ergosterol-related terms.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0030968","count":1},{"id":"GO:0097250","count":1},{"id":"GO:0090201","count":1},{"id":"GO:0033617","count":1}]},{"hash":"1497817808975900715","title":"Vertebrate Eye and Cranial Patterning","description":"This cluster centers on embryonic eye morphogenesis and cranial development, with terms like camera-type eye development and embryonic eye morphogenesis, plus left/right pattern formation and rhombomere 4 development indicating hindbrain patterning. The presence of transcription regulation terms suggests coordinated gene networks governing these developmental processes, supporting a theme of vertebrate eye formation combined with cranial patterning.","confidence":"High","size":17,"edges":15,"triangles":2,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060441","count":8},{"id":"GO:0043010","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0007275","count":8}]},{"hash":"2053978295611000587","title":"Ion transport and T cell signaling","description":"This cluster shows clear enrichment for transmembrane ion transport (potassium and sodium) and for T cell\u2013related signaling (costimulation and proliferation), suggesting a coherent theme around membrane transport proteins with immune-modulating roles. The kidney development term hints at a renal context but is less central to the dominant ion-transport and T cell signaling pattern. Confidence: Medium","confidence":"","size":17,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0051092","count":2},{"id":"GO:0014068","count":2}]},{"hash":"1352375264722702975","title":"Mitochondrial dynamics and innate immune signaling","description":"The top GO terms converge on mitochondria: regulation of fission and fusion and mitochondrion localization, alongside innate immune responses (defense against Gram-positive bacteria, type I interferon response) and apoptosis. This suggests a cluster of proteins that mechanistically link mitochondrial dynamics with immune signaling and stress responses, rather than a single trafficking pathway.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0090141","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0045087","count":3}]},{"hash":"784845844785733202","title":"Oxidative stress response and embryonic development","description":"This cluster centers on responses to xenobiotic and toxic substances, oxidative (hydrogen peroxide) metabolism, apoptosis, and developmental processes (multicellular and embryonic development), suggesting a link between redox biology and development. The mix of stress-response and developmental GO terms supports this as a cohesive theme, though some terms are broad. ","confidence":"Medium","size":17,"edges":39,"triangles":17,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0050665","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0055114","count":3}]},{"hash":"2153285009157270004","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":17,"triangles":1,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0044209","count":4},{"id":"GO:0032869","count":3},{"id":"GO:0006541","count":3},{"id":"GO:0021895","count":3},{"id":"GO:0007625","count":3}]},{"hash":"1377311236306787193","title":"Embryonic development and organ differentiation","description":"The dominant GO terms point to embryogenesis and tissue formation, including left/right patterning, endocrine system development, placental/trophoblast differentiation, and cartilage morphogenesis. A couple terms reference sensory perception, but these are less representative of the overall theme. Thus the cluster is best described as relating to embryonic development and subsequent organ differentiation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0060972","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060707","count":5}]},{"hash":"334598215053872193","title":"Developmental signaling and cytoskeletal dynamics","description":"These terms point to roles in developmental signaling (heart development, Smoothened pathway, JNK regulation) and neural communication (GABAergic transmission), alongside cytoskeletal and vesicular trafficking functions (tubulin assembly, filopodium formation, Golgi to plasma membrane transport) and cellular stress responses (mechanical stimulus). The combination suggests a cluster centered on developmental signaling intertwined with cytoskeletal dynamics and intracellular transport.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0006893","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0032258","count":2},{"id":"GO:0007021","count":2}]},{"hash":"155202023945039622","title":"Lipid Catabolism and Triglyceride Mobilization","description":"The top GO terms are dominated by triglyceride and phospholipid catabolic processes (triglyceride catabolism, triglyceride mobilization, phosphatidylcholine and phosphatidylethanolamine catabolism) and triglyceride acyl-chain remodeling, indicating a cohesive theme of lipid breakdown and mobilization. While a few regulatory signals (PKA, NF-kappaB, STAT) and hepatocyte apoptosis appear, they are secondary to the lipid-centric metabolism theme.","confidence":"High","size":17,"edges":68,"triangles":61,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0046338","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0010898","count":5},{"id":"GO:0036153","count":5},{"id":"GO:0006642","count":5}]},{"hash":"1031039851022795343","title":"Unknown","description":"The top GO terms are highly diverse, including neural functions (visual learning, response to cocaine), immune signaling (interferon response, B cell regulation), development (oocyte development), telomere maintenance, metal ion response, plant signaling, and various regulatory processes. There isn't a clear, cohesive biological theme linking these terms to a single functional cluster, so a specific, intuitive label isn\u2019t supported.","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0071357","count":1},{"id":"GO:0048599","count":1},{"id":"GO:0032212","count":1}]},{"hash":"1392685234774894135","title":"DNA Repair and Genome Maintenance","description":"The top GO terms point to DNA repair and genome stability (DNA recombination, base-excision repair, DNA catabolic process) and cell-cycle control (G1/S transition), suggesting proteins involved in maintaining genome integrity. Additional signals like redox homeostasis and mRNA stability regulation reflect linked stress responses. A few terms (corneocyte development, renal water transport) seem peripheral, but the core theme is DNA repair and genome maintenance.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0007568","count":6},{"id":"GO:0006284","count":6},{"id":"GO:0043488","count":5},{"id":"GO:2001153","count":5}]},{"hash":"2038820533894274339","title":"Integrin signaling and cytoskeletal remodeling","description":"The top GO terms cluster around regulation of integrin activation and integrin-mediated adhesion, along with Rho signaling and stress fiber assembly, which point to cytoskeletal remodeling governing cell adhesion. Angiogenesis and phagolysosome components also appear, suggesting vascular growth and some immune-associated roles, but the dominant theme is integrin- and cytoskeleton-related regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0021744","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0033628","count":4},{"id":"GO:0033623","count":4}]},{"hash":"1883570710939052554","title":"GPCR-cAMP Signaling in Vascular and Immune Regulation","description":"The top GO terms are dominated by adenylate cyclase\u2013activating GPCR signaling and activation of adenylate cyclase, with strong signals for vascular regulation (vasopressin, blood pressure) and immune processes (IL-1\u03b2 production, dendritic cell differentiation). Temperature and photoreceptor maintenance add environmental/sensory context, while electron transport chain hints at general metabolic activity. Taken together, the cluster centers on GPCR-cAMP signaling that modulates vascular/immune functions, with ancillary metabolic and sensory associations.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0045777","count":16},{"id":"GO:0007190","count":16},{"id":"GO:0045494","count":14}]},{"hash":"194701505546467903","title":"Immune-vascular signaling regulators","description":"This cluster includes GO terms tied to signaling pathway modulation across immune and vascular contexts, such as endothelial cell chemotaxis via VEGF signaling, ERK cascade regulation, Rho/GTPase signaling, B cell receptor signaling, and myeloid differentiation. The common theme is broad regulation of signal transduction affecting immune and vascular cell behavior rather than a single, narrow function.","confidence":"Medium","size":17,"edges":15,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0038033","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0002318","count":2},{"id":"GO:0046627","count":2},{"id":"GO:0070374","count":2}]},{"hash":"493529065728651663","title":"Acetyl-CoA and Fatty Acid Metabolism","description":"The top GO terms point to acetyl-CoA biosynthesis from acetate, pyruvate-to-acetate flux, and especially fatty acid biosynthesis and medium-chain fatty-acyl-CoA metabolism and transport. This suggests the cluster centers on lipid metabolism and acetyl-CoA\u2013related pathways, with a few outlier terms (e.g., siderophore biosynthesis, seed germination regulation) that are less connected to this theme.","confidence":"Medium","size":17,"edges":97,"triangles":256,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0019427","count":5},{"id":"GO:0010124","count":5},{"id":"GO:1902987","count":5},{"id":"GO:0019654","count":5},{"id":"GO:0006633","count":5}]},{"hash":"435663216088588333","title":"Diverse Membrane Transporters","description":"GO terms show a strong emphasis on transmembrane transport of ions and small molecules, including potassium, sodium, phosphate, nitrate/nitrite, galactose, fucose, and xenobiotics, plus neurotransmitter loading into synaptic vesicles. This indicates a cluster of proteins whose primary function is transporting substrates across membranes rather than catalyzing a single metabolic reaction. High","confidence":"","size":17,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":8},{"id":"GO:0035725","count":8},{"id":"GO:0098700","count":7},{"id":"GO:0006004","count":7},{"id":"GO:0035435","count":7}]},{"hash":"1638993317581394063","title":"Aldosterone and Vitamin D Endocrine Pathways","description":"The top GO terms include aldosterone biosynthesis and renal-aldosterone\u2013related regulation of blood volume, plus responses and catabolic processes involving vitamin D, which together point to an endocrine axis centered on steroid hormone synthesis and vitamin D metabolism. Some unrelated terms (e.g., oxylipin biosynthesis, isoquinoline alkaloid metabolism) are present, but the core signals suggest this endocrine theme. Therefore, a cohensive label is Aldosterone and Vitamin D Endocrine Pathways.","confidence":"Medium","size":17,"edges":6,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0033076","count":6},{"id":"GO:0031408","count":6},{"id":"GO:0010164","count":6},{"id":"GO:0032342","count":6},{"id":"GO:0002017","count":6}]},{"hash":"1945001510744141437","title":"Unknown","description":"These proteins show a highly heterogeneous set of GO terms spanning immune regulation (foam cell differentiation), sensory perception (pain), synaptic regulation, cell division, NF-kappaB signaling, telomere maintenance, adipocyte differentiation, CDK activity, heart development, and salicylic acid signaling. There is no single coherent biological process or pathway that ties all terms together, and the list includes an obsolete GO term as well as terms from disparate areas. With no edges or functional connectivity, it is not possible to assign a specific function; the cluster is best labeled Unknown. ","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010745","count":7},{"id":"GO:0050968","count":6},{"id":"GO:1900383","count":6},{"id":"GO:0051225","count":6},{"id":"GO:0007253","count":6}]},{"hash":"1630978595542736915","title":"Fatty acid and sphingolipid biosynthesis with retinoic acid","description":"Top terms show a clear emphasis on lipid metabolism (fatty acid elongation, sphingolipid biosynthesis) and retinoic acid biosynthesis, which together point to lipid-derived signaling pathways. While other terms (lung development, transcription regulation, plant-specific biosynthetic processes) suggest broader or noisy annotations, the core theme remains lipid biosynthesis and vitamin A\u2013related signaling. Confidence in this label is Medium.","confidence":"","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0030324","count":4},{"id":"GO:0006355","count":4},{"id":"GO:0009710","count":4},{"id":"GO:0042761","count":4}]},{"hash":"1788069736535968479","title":"Nuclear import and chromosome segregation during cell division","description":"This cluster is characterized by GO terms centered on nuclear import (NLS-bearing and ribosomal protein import into the nucleus), nuclear envelope dynamics during mitosis (mitotic nuclear membrane reassembly), and chromosome segregation events in both mitosis and meiosis (sister chromatid separation and centromeric cohesion). These recurring themes suggest proteins that function in nuclear transport and in organizing/changing chromosomes during cell division; a few apoptosis- or desumoylation-related terms appear peripheral. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":5},{"id":"GO:1903538","count":4},{"id":"GO:0060188","count":4},{"id":"GO:0006607","count":4},{"id":"GO:0006610","count":4}]},{"hash":"1835522107933804781","title":"Developmental morphogenesis and muscle/neural differentiation","description":"The cluster shows enrichment for developmental and morphogenetic processes, especially skeletal muscle development and nervous system development, along with sarcomere organization, suggesting roles in muscle/nerve differentiation and cytoskeletal assembly. Additional morphogenesis terms across other tissues (distal tubule, salivary gland, renal) point to broader developmental programs, and ubiquitin-dependent protein catabolic process hints at protein turnover linked with development. Overall, the proteins seem tied to developmental regulation and cytoskeletal organization across tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:1900242","count":16},{"id":"GO:0045214","count":16},{"id":"GO:0072156","count":16},{"id":"GO:0007399","count":16}]},{"hash":"329274343964965372","title":"Ubiquitin-dependent NF-\u03baB/TNF signaling","description":"This cluster is dominated by ubiquitination-related processes (ubiquitin-dependent protein catabolic process, protein autoubiquitination) and enrichment of NF-\u03baB/TNF signaling terms (I-kappaB phosphorylation, NF-kappaB-inducing kinase activity, TNF-mediated signaling). The co-occurrence of these functions suggests a cohesive theme where protein turnover via ubiquitin regulates inflammatory signaling pathways, with some histone-related turnover likely reflecting transcriptional regulation. Confidence: High","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0051865","count":8},{"id":"GO:0036205","count":7},{"id":"GO:1903721","count":7},{"id":"GO:0070535","count":7}]},{"hash":"2101554796512518929","title":"Thermal and immune-vascular signaling","description":"This cluster shows strong representation of temperature-related processes (cellular response to temperature stimulus, diet-induced thermogenesis) alongside immune and vascular functions (IL-1\u03b2 production, dendritic cell differentiation, vasopressin-regulated blood pressure, coagulation). While a few terms are broader, the dominant theme links temperature stress to immune signaling and vascular regulation, suggesting a coordinated thermo-immune-vascular role for these proteins.","confidence":"Medium","size":17,"edges":39,"triangles":9,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":11},{"id":"GO:0002024","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0045494","count":7},{"id":"GO:0001992","count":7}]},{"hash":"1303902391757786484","title":"GPCR Signaling and Metabolic Regulation","description":"Top terms point to GPCR-mediated signaling and cAMP production, with links to Rho signaling and vasopressin-regulated blood pressure. Energy metabolism is indicated by the electron transport chain, while photoreceptor maintenance and immune-related terms suggest broader sensory and immune signaling roles. The common thread is signal transduction coupled to cellular energy and vascular/immune regulation, so GPCR Signaling and Metabolic Regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0035025","count":14},{"id":"GO:0007190","count":14}]},{"hash":"1052220116051329558","title":"Neuroimmune and developmental signaling","description":"The top GO terms span neural development (myelination, synapse assembly), innate immune signaling (TLR3/9 pathways), cytokine production (IL-6, interferon-\u03b1), and tissue remodeling (collagen fibril organization, metanephric proximal tubule development), plus autophagy and mitochondrial fission; together they suggest a broad axis of neuroimmune communication integrated with developmental remodeling rather than a single, focused function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":13},{"id":"GO:0051965","count":13},{"id":"GO:0034162","count":12},{"id":"GO:0045410","count":12},{"id":"GO:0090141","count":12}]},{"hash":"2247389199318395579","title":"Bacterial cell wall biosynthesis and morphogenesis","description":"The GO terms cluster around core cell envelope processes: peptidoglycan biosynthesis, teichoic acid biosynthesis, lipid A biosynthesis, and UDP-N-acetylglucosamine production, all essential for bacterial cell wall construction. Additional terms like regulation of cell shape and cell morphogenesis support a theme of envelope remodeling and division. The presence of terpenoid and MEP pathway\u2013related biosynthesis suggests production of lipid carriers and membrane components tied to cell wall assembly. Although a mitotic cell cycle term appears, the overall pattern strongly points to bacterial cell wall biosynthesis and morphogenesis. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0035269","count":1},{"id":"GO:0009252","count":1},{"id":"GO:0006048","count":1}]},{"hash":"688544737195156377","title":"Germinal center B cell regulation","description":"The GO terms point to germinal center formation, immunoglobulin-mediated responses, and regulation of B cell proliferation and isotype switching (IgA), complemented by MyD88-dependent TLR signaling and regulatory controls on neutrophil migration and apoptosis. This pattern fits a modulatory immune module centered on B cell activation and germinal center processes rather than a single effector pathway. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002467","count":3},{"id":"GO:0016064","count":2},{"id":"GO:1902622","count":2},{"id":"GO:0030889","count":2},{"id":"GO:2000002","count":2}]},{"hash":"1815626842403149577","title":"Glutamatergic synaptic signaling and plasticity","description":"The cluster\u2019s strongest signals are in glutamatergic synaptic transmission, receptor clustering, and regulation of short-term synaptic plasticity, with related neuropharmacology (morphine, lithium) and neurobehavioral terms. While a few terms refer to broader developmental processes, the dominant theme points to neuronal communication and synaptic modulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0043113","count":4},{"id":"GO:0035249","count":4},{"id":"GO:0043278","count":4},{"id":"GO:0048172","count":4}]},{"hash":"489646610533397933","title":"LPS-TLR4-driven innate immune response","description":"The cluster is dominated by GO terms tied to lipopolysaccharide detection and signaling, TLR4 pathway activation, innate immune response, and inflammatory signaling, indicating a coherent theme of LPS-triggered innate immunity. Some terms about myelination, collagen fibril organization, and regulation of angiogenesis may reflect associated tissue remodeling during inflammation, but the strongest signal centers on LPS/TLR4\u2013mediated immune activation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0007252","count":2},{"id":"GO:0032497","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0006954","count":2}]},{"hash":"440234774394473634","title":"Dexamethasone-responsive transcription regulators","description":"This cluster is dominated by GO terms for DNA-templated transcription and positive regulation of transcription by RNA polymerase II, along with a cellular response to dexamethasone stimulus. The combination points to transcriptional regulation in response to glucocorticoid signaling, with developmental terms likely reflecting broader differentiation contexts. Thus, a label capturing glucocorticoid-driven transcriptional regulation fits best.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0071549","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0072001","count":2},{"id":"GO:0097186","count":2}]},{"hash":"145224368750365808","title":"Embryonic Tissue Morphogenesis and Patterning","description":"The cluster shows broad enrichment for developmental processes across multiple tissues, including left/right patterning, endocrine system development, EMT in heart cushion formation, placental/trophoblast differentiation, cartilage morphogenesis, palate development, and vascular morphogenesis, indicating a cohesive theme of embryonic tissue formation and organ patterning.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":11},{"id":"GO:0003323","count":11},{"id":"GO:0035270","count":11},{"id":"GO:0003198","count":11},{"id":"GO:0060707","count":11}]},{"hash":"1842316748204140344","title":"Innate immunity and leukocyte recruitment","description":"The top GO terms are dominated by innate immune functions: complement activation via the lectin pathway, phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and cellular responses to fungal origin. Although some development terms (kidney/duct, lymph vessel morphogenesis) appear, they seem secondary to the strong immune signal, suggesting the cluster mainly reflects innate immune activation and leukocyte trafficking.","confidence":"High","size":16,"edges":19,"triangles":1,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":15},{"id":"GO:0072177","count":11},{"id":"GO:0006910","count":11},{"id":"GO:0072218","count":11},{"id":"GO:0050901","count":11}]},{"hash":"794263955374823413","title":"Unknown","description":"The top GO terms span transcriptional regulation and a wide range of immune and developmental processes (dsRNA and LPS responses, GM-CSF and VEGF signaling, B cell maturation, heart and placental/vascular development). This broad mix lacks a single cohesive function or pathway, making a specific, representative label difficult; therefore it\u2019s best described as Unknown with no confidence.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0043330","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0060716","count":2}]},{"hash":"733190982738355629","title":"Developmental Signaling and Kinase/GTPase Regulation","description":"Proteins here show enrichment for positive regulation of GTPase activity and serine/threonine kinase activity, along with heterotrimerization, and development-related terms (multicellular organism development and skin development). Additional terms like mitotic cell cycle, mRNA transport, hypoxia response, and ubiquitin-dependent proteolysis suggest a coordinated network governing signaling, cell proliferation, gene expression, and protein turnover during tissue development. Altogether, this points to a theme of developmental signaling and regulation of protein activity.","confidence":"Medium","size":16,"edges":4,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0070208","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0071902","count":4},{"id":"GO:0000278","count":4}]},{"hash":"2042590768493477761","title":"Broad Developmental Signaling Network","description":"The GO terms point to a wide array of signaling and developmental roles, including neural development (axon regeneration, cerebellar cortex formation, LTP), transcriptional regulation (DNA-templated transcription), and signaling pathways (Wnt, insulin, T cell receptor), plus angiogenesis and differentiation. There is no single, narrow function tying all proteins together, but they consistently relate to regulation of signaling during development across tissues.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048679","count":11},{"id":"GO:0030216","count":11},{"id":"GO:0060044","count":11},{"id":"GO:0008286","count":11},{"id":"GO:0060291","count":11}]},{"hash":"1298378115755435225","title":"Ribosome and translation machinery","description":"This cluster is dominated by translation-related GO terms across multiple stages (initiation, elongation, termination), plus ribosomal large subunit assembly and selenocysteine incorporation, indicating a core role in protein synthesis. The inclusion of mRNA decay and translational regulation terms supports a broader theme of translation control, with a few peripheral terms like glial proliferation or antibiotic response likely representing secondary associations.","confidence":"High","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0046677","count":5},{"id":"GO:0006415","count":5},{"id":"GO:0000027","count":3},{"id":"GO:0001514","count":3}]},{"hash":"1763118645284771234","title":"Chromatin remodeling and heterochromatin formation","description":"The top GO terms are dominated by chromatin-related processes: transcription initiation-coupled chromatin remodeling, DNA replication-dependent chromatin assembly, rDNA and subtelomeric/centromeric heterochromatin formation, and related chromatin organization activities. This points to a cohesive theme of chromatin dynamics governing genome structure and transcription, with a few development-related terms (spermatid development, osteoblast differentiation, vitellogenesis) likely reflecting broader roles of chromatin regulation in developmental programs. Overall, a chromatin remodeling/heterochromatin formation theme best explains the cluster.","confidence":"High","size":16,"edges":117,"triangles":521,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045815","count":14},{"id":"GO:0006335","count":14},{"id":"GO:0051290","count":14},{"id":"GO:0000183","count":14},{"id":"GO:0007296","count":12}]},{"hash":"1080073960719507991","title":"Immune Signaling and Immunological Synapse","description":"The top GO terms center on innate immune response, immunological synapse formation, NK cell regulation, and T cell receptor signaling, with downstream ERK/MAPK and GTPase activity pathways. This points to a cohesive function in immune cell activation and communication, despite a few development-related terms that appear less central. Confidence: High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0001771","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0045953","count":2}]},{"hash":"870905788592919250","title":"Extracellular matrix remodeling and tissue development","description":"The cluster\u2019s top GO terms cluster around tissue morphogenesis and ECM-related processes: collagen fibril organization, connective tissue development (lung, nipple), prostate gland development, and cross-linking of glycosaminoglycans, plus blood coagulation which often ties to ECM remodeling. These suggest a common theme of ECM dynamics and tissue development. A few terms (innate immune response, spliceosomal assembly, mitotic regulation) are less aligned and likely represent secondary roles or outliers. Overall, the label captures the dominant theme of ECM-related tissue development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030850","count":3},{"id":"GO:0007596","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0045842","count":2},{"id":"GO:0051607","count":2}]},{"hash":"115077772921406583","title":"Immune signaling and angiogenesis","description":"The top GO terms cluster around immune activation and vascular remodeling, including interleukin-1 signaling, NF-kappaB transcription factor activity regulation, and T cell receptor signaling, plus angiogenesis and integrin-mediated signaling. A few terms touch neural development or general cellular processes, which may reflect broader signaling connections or annotation noise, but the dominant theme is immune signaling with links to angiogenesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0070498","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0021987","count":3}]},{"hash":"57849213317742908","title":"Embryonic Development and Growth","description":"The top GO terms cluster around developmental processes such as male gonad development, in utero embryonic development, single fertilization, and multicellular organism growth. While there are some immune-related terms and a general transcription regulatory term present, the strongest signal is embryonic development and organismal growth, suggesting these proteins co-function in developmental regulation with some ancillary roles in immunity. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0035264","count":3}]},{"hash":"409470788664856807","title":"Unknown","description":"The top GO terms mix immune defense (innate immune response, defense against virus) with diverse developmental processes (pancreatic and endocrine development, placental/trophoblast differentiation, left-right patterning, EMT in heart development). With only a couple of terms per category and no clear, shared function, there isn\u2019t a cohesive theme to label a specific function for this cluster.","confidence":"","size":16,"edges":16,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0060972","count":2}]},{"hash":"1596551899240435808","title":"Developmental signaling and neuro-immune interactions","description":"The GO terms point to development (heart development), neuronal signaling and plasticity (long-term potentiation/depression), and immune responses (innate immunity, defense against bacteria, lipopolysaccharide response), all connected through shared signaling pathways like integrin signaling, GTPase regulation, and ERK cascades. This pattern suggests a cluster of proteins involved in developmental signaling with cross-talk between neural, cardiovascular, and immune functions, including myelination. Since no single dominant function stands out, the label reflects broad developmental and neuro-immune signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007229","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0071222","count":3}]},{"hash":"408327553401824558","title":"Ubiquitin-Proteasome Regulation and NF-kappaB Signaling","description":"The cluster's top GO terms center on ubiquitin-dependent protein catabolism (including SCF-mediated processes and polyubiquitination) and autoubiquitination, plus components of NF-kappaB and TNF signaling (I-kappaB phosphorylation, IKK activation). This points to a cohesive role in marking proteins for degradation and modulating inflammatory signaling through NF-kappaB, with histone turnover as a related ubiquitin-mediated process. Confidence is high that this label captures the cluster's primary function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0031146","count":7},{"id":"GO:1903721","count":6},{"id":"GO:0007250","count":6},{"id":"GO:1903265","count":6}]},{"hash":"1232728754733867603","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":14,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007014","count":7},{"id":"GO:0001519","count":7},{"id":"GO:1902187","count":7},{"id":"GO:1903883","count":7},{"id":"GO:1903265","count":7}]},{"hash":"1066641427763509020","title":"Immune Signaling and Junctional Adhesion","description":"Most proteins map to immune system processes (adaptive and innate immunity, B cell receptor signaling, IL-2 production) and to cell\u2013cell junctions/cytoskeletal regulation (tight junction assembly, cell adhesion, Rho signaling). The shared theme is immune signaling intertwined with modulation of cell contacts and actin dynamics, rather than a single metabolic pathway; the heart development term appears less central and may reflect pleiotropy. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0002250","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0050853","count":2}]},{"hash":"1882660616539347032","title":"Embryonic tissue patterning and organogenesis","description":"The dominant GO terms point to embryonic development and the formation of organs and tissues (left-right patterning, pancreas/endocrine development, heart cushion EMT, cartilage morphogenesis, palate formation). A couple of items (spliceosome-mediated splicing, vitamin D biosynthetic regulation) are peripheral and do not define the core theme. Overall, the cluster is best described as embryonic tissue patterning and organogenesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":10},{"id":"GO:0003323","count":10},{"id":"GO:0035270","count":10},{"id":"GO:0003198","count":10},{"id":"GO:0060707","count":10}]},{"hash":"1195198478594427977","title":"Embryogenesis with Angiogenesis and Immune Signaling","description":"The top GO terms point to developmental processes (midbrain development, primitive streak formation) and pro-angiogenic activity, complemented by proteolytic remodeling (plasminogen activation, fibrinolysis) and innate immune signaling (complement activation, Toll pathway, IL-1\u03b2 production). This suggests a module coordinating early development with tissue remodeling and immune responses, rather than a single narrow function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":6},{"id":"GO:0001867","count":4},{"id":"GO:0031639","count":4},{"id":"GO:0045766","count":4}]},{"hash":"436655036163374594","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":11,"triangles":1,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002755","count":6},{"id":"GO:0043123","count":6},{"id":"GO:0071651","count":5},{"id":"GO:0034145","count":5},{"id":"GO:2000340","count":5}]},{"hash":"2083273269439723153","title":"Neurodevelopmental signaling and spine morphogenesis","description":"This cluster centers on developmental signaling pathways such as Hedgehog (Smoothened) and ROBO signaling, plus factors involved in dendritic spine morphogenesis and Rac-mediated signal transduction. The presence of trafficking (Golgi to plasma membrane) aligns with receptor signaling and membrane trafficking needed for these processes, suggesting a coherent theme around nervous system development and synaptic spine formation, with some related developmental terms (kidney and nervous system development) appearing as broader context.","confidence":"Medium","size":16,"edges":41,"triangles":18,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007224","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0006893","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0001822","count":4}]},{"hash":"1123402918953799400","title":"ER protein-folding and oxidative-stress response","description":"The cluster is enriched for GO terms centered on protein folding in the endoplasmic reticulum, unfolded protein response, and cellular responses to oxidative stress and hydrogen peroxide, with redox homeostasis also represented. Together these point to a coordinated ER protein quality-control/folding program activated by oxidative stress. A transcription-related term is present but appears less central to the core theme. ","confidence":"High","size":16,"edges":71,"triangles":147,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034975","count":12},{"id":"GO:0045454","count":11},{"id":"GO:0070301","count":9},{"id":"GO:0006351","count":8},{"id":"GO:0034599","count":8}]},{"hash":"2220905517545195370","title":"Actin Cytoskeleton Dynamics and Cell Migration","description":"The top GO terms center on actin filament bundle assembly, actin cytoskeleton remodeling, and regulation of cell migration and spreading, spanning neuronal spine morphogenesis to general cell motility. This suggests proteins that coordinate actin dynamics and adhesion-dependent movement across contexts.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000251","count":6},{"id":"GO:0051017","count":5},{"id":"GO:0061001","count":5},{"id":"GO:0034446","count":5},{"id":"GO:0007121","count":4}]},{"hash":"925940797934508543","title":"Unknown","description":"The top GO terms span both innate immune signaling (TLR3/9 pathways and cytokine production like IL-6 and interferon) and a mix of development/differentiation processes (epithelial polarity, myelination, neuronal migration, kidney development) plus mitochondrial fission and chromatin localization. There isn\u2019t a single cohesive function or pathway that ties all terms together, making a concise, intuitive label difficult to justify.","confidence":"","size":16,"edges":7,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071169","count":7},{"id":"GO:0034162","count":6},{"id":"GO:0045410","count":6},{"id":"GO:0090141","count":6},{"id":"GO:0016336","count":6}]},{"hash":"2066291907785102081","title":"Diverse small-molecule metabolism","description":"The top GO terms cover metabolism of vitamins (retinol/retinal, pyridoxal), various sugars (fructose, arabinose), xenobiotic and lipid-related compounds (naphthalene, bile acid), and even norepinephrine processing, plus a stress-activated kinase signaling cue. This pattern points to a cluster of proteins involved in broad, diverse small-molecule metabolic pathways rather than a single, cohesive pathway. ","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":16},{"id":"GO:0042574","count":16},{"id":"GO:0030573","count":15},{"id":"GO:0018931","count":15},{"id":"GO:0046370","count":15}]},{"hash":"889277754253902213","title":"Amino acid biosynthesis and catabolism","description":"The top GO terms point to biosynthetic processes for multiple amino acids (serine, tryptophan, threonine, pyruvate as a precursor) and to catabolic/homocysteine/cysteine pathways, including hydrogen sulfide production. This pattern indicates the cluster centers on amino acid metabolism rather than a single specific pathway, encompassing both synthesis and degradation interconversions. Confidence reflects a cohesive metabolic theme across several amino acids.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006565","count":10},{"id":"GO:0043418","count":8},{"id":"GO:0070179","count":8},{"id":"GO:0006535","count":8},{"id":"GO:0070814","count":8}]},{"hash":"1246707623993549029","title":"Unknown","description":"The terms span negative regulation of several signaling pathways (HIF-1alpha, NF-kappaB, TNF), membrane trafficking and localization processes, apoptosis, and basic metabolism, with no clear single theme tying all proteins together. This makes it hard to assign a cohesive, specific label beyond Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902072","count":1},{"id":"GO:1902306","count":1},{"id":"GO:2000009","count":1},{"id":"GO:0032088","count":1},{"id":"GO:0048227","count":1}]},{"hash":"652029066589724862","title":"MAPK signaling and metabolism regulation","description":"The cluster centers on regulation of signaling pathways (GTPase activity, phosphorylation, ERK/MAPK cascade) with accompanying metabolic and growth-related processes (lipid biosynthesis, osteoblast proliferation, cholesterol response). The GO terms suggest a shared theme of signaling-regulated metabolic/growth processes rather than a single pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0010867","count":5},{"id":"GO:2000060","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0006469","count":4}]},{"hash":"1107376685478879708","title":"Neuronal signaling and receptor regulation","description":"The top GO terms cluster around neural communication and receptor dynamics: acetylcholine receptor signaling, GABA receptor clustering, and modulation of nerve impulse transmission, plus related nervous-system behaviors like startle response and conditioned taste aversion. While other terms touch on immune responses and metabolism, the strongest and most coherent theme is neuronal signaling and receptor regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009615","count":3},{"id":"GO:0001964","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0071222","count":2}]},{"hash":"955928531168173092","title":"Developmental morphogenesis and patterning","description":"The top GO terms cluster around embryonic development, body morphogenesis, and tissue patterning (embryonic morphogenesis, fungiform papilla formation, chitin-based larval cuticle patterning, embryonic body morphogenesis). Additional terms point to core gene expression and structural organization (NLS-bearing protein import into nucleus, transcription initiation-coupled chromatin remodeling, intermediate filament assembly) and organogenesis-related functions (heart rate regulation, bundle of His/Purkinje adhesion). Taken together, the proteins appear linked to developmental processes across tissues rather than a single specific function, justifying a broad developmental label.","confidence":"Medium","size":16,"edges":115,"triangles":496,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0061198","count":12},{"id":"GO:0006607","count":12},{"id":"GO:0015991","count":12},{"id":"GO:0048096","count":12},{"id":"GO:0045976","count":12}]},{"hash":"1912937794166301116","title":"Proteolysis and peptide maturation","description":"The top GO terms point to proteolysis and multiple peptide-processing/maturation processes (including enkephalin processing and peptide pheromone maturation, and dibasic protein processing). This suggests a cohesive theme around proteolytic processing of peptide precursors into mature signaling molecules, even though other terms are more general or unrelated. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032760","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0010467","count":2},{"id":"GO:1905596","count":1},{"id":"GO:1905598","count":1}]},{"hash":"1449859931096035182","title":"Diverse Signaling and Regulatory Processes","description":"The cluster includes GO terms spanning vitamin D response, GPCR signaling, sensory detection of pain, synaptic plasticity regulation, spindle assembly, NF-kappaB regulation, telomere maintenance, adipocyte differentiation, cyclin-dependent kinase activity, and cardiac morphogenesis. This mix points to a collection of signaling and regulatory processes across cellular signaling, cell cycle control, differentiation, and development, rather than a single well-defined function. Therefore, the label reflects broad regulatory signaling and cellular processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":6},{"id":"GO:0007205","count":5},{"id":"GO:0050968","count":4},{"id":"GO:1900383","count":4},{"id":"GO:0051225","count":4}]},{"hash":"1194747797083681723","title":"Gene Expression and Cell-Cycle Regulation","description":"Although the cluster includes a mix of annotations (some nervous system and developmental terms), the strongest and most recurring themes are DNA-templated transcription regulation and control of kinase activity and cell-cycle processes (spindle assembly, CDK-related regulation, telomere maintenance). Together these suggest a core function in coordinating gene expression with cell division during development, with some peripheral terms reflecting broader developmental roles.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0006469","count":5},{"id":"GO:0050968","count":5},{"id":"GO:1900383","count":5},{"id":"GO:0051225","count":5}]},{"hash":"91638834014831248","title":"Developmental signaling and ubiquitin regulation","description":"Most top GO terms relate to organismal development (skin development, multicellular organism development, seminiferous tubule development). A subset also points to regulatory signaling (positive regulation of canonical NF-kappaB signaling, positive regulation of GTPase activity) and post-translational modification (protein polyubiquitination). Together these suggest a cluster of proteins involved in developmental signaling with ubiquitin- and GTPase-mediated regulation. The lack of network edges means the proteins were added by recipe but share a broad developmental/regulatory theme rather than a single, specific molecular function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0009405","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0043123","count":3}]},{"hash":"1692710747494316924","title":"Global regulation of cellular processes","description":"It links terms such as negative regulation of serine/threonine kinase activity, regulation of cyclin-dependent kinase activity, telomere maintenance, fat cell differentiation, triglyceride biosynthesis, cell migration, and mRNA processing\u2014covering broad regulatory roles across signaling, metabolism, and gene expression. The common thread is modulation of diverse cellular functions rather than a single pathway, so a broad label is appropriate.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071901","count":6},{"id":"GO:0010867","count":5},{"id":"GO:0032212","count":4},{"id":"GO:0045736","count":4},{"id":"GO:0045444","count":4}]},{"hash":"804415567639053713","title":"Neural signaling and myelination","description":"The top GO terms cluster around neural communication and plasticity (cell communication, long-term synaptic depression, GPCR signaling pathway), and myelin-related processes (myelination, galactosylceramide biosynthetic process), with cardiovascular regulation likely mediated by neural control (positive regulation of blood pressure, force of heart contraction). The combination suggests a central theme of nervous system signaling and myelin biology, with some supportive links to energy metabolism and cardiovascular function. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0006682","count":3}]},{"hash":"1721069332086786419","title":"Glycogen, starch, and glucan metabolism","description":"The proteins are dominated by carbohydrate metabolism GO terms, including maltose metabolic process, alpha-glucan biosynthesis and catabolism, glycogen and starch biosynthesis/catabolism, trehalose catabolic process, and related oligosaccharide metabolism. This points to a cohesive theme of storage and turnover of starch-like glucans and related sugars, spanning both biosynthetic and degradative pathways. Confidence in this label is High.","confidence":"","size":16,"edges":10,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000023","count":5},{"id":"GO:0030979","count":4},{"id":"GO:0030980","count":4},{"id":"GO:0005980","count":4},{"id":"GO:0005978","count":4}]},{"hash":"1606252347605458901","title":"TLR-driven innate immune signaling and cytokine production","description":"The cluster\u2019s top GO terms are strongly dominated by Toll-like receptor pathways (TLR9 and TLR3 signaling) and positive regulation of cytokines (IL-6 and interferon-\u03b1), along with autophagy regulation. This points to a core function in innate immune sensing and antiviral responses, with additional terms possibly reflecting broader or multifunctional roles of the proteins. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0034162","count":4},{"id":"GO:0045410","count":4},{"id":"GO:0090141","count":4},{"id":"GO:0016336","count":4},{"id":"GO:0042552","count":4}]},{"hash":"1028190236591389449","title":"Cardiac morphogenesis and mechanotransduction","description":"The cluster is dominated by terms tied to heart development and mechanotransduction: right atrium morphogenesis, venous endothelial differentiation, and Notch signaling in heart-field proliferation, plus cellular response to mechanical stimulus. Some terms reference neural signaling and pain perception, which may reflect broader, multifaceted roles of these proteins, but the core theme points to cardiac morphogenesis and mechanosensitive signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003213","count":4},{"id":"GO:0048265","count":4},{"id":"GO:0060843","count":4},{"id":"GO:0003270","count":4},{"id":"GO:0071260","count":4}]},{"hash":"905863018785118120","title":"Neural development and apoptosis regulation","description":"The cluster\u2019s top GO terms cluster around brain development, learning and behavior (brain development, visual learning, social behavior), and neuronal apoptosis regulation (intrinsic apoptotic signaling in response to DNA damage, positive regulation of neuron apoptotic process). Though a few terms are more peripheral (response to cocaine, ectopic germ cell death), the dominant theme ties neural development with mechanisms controlling neuron survival, suggesting a coherent neural function cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048671","count":3},{"id":"GO:0008542","count":2},{"id":"GO:0035234","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0035176","count":2}]},{"hash":"1665780704385791038","title":"Inflammation, complement activation, and platelet activation","description":"The top GO terms point to inflammatory signaling (interleukin-1 response), activation of the lectin complement pathway, and platelet-related processes, along with cell-matrix adhesion and angiogenesis regulation. Together these suggest a cohesive theme of inflammatory-immune signaling coupled with coagulation/platelet function and endothelial interactions.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":6},{"id":"GO:0016525","count":6},{"id":"GO:0007171","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0007160","count":6}]},{"hash":"1481308939105581996","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning immune defense (virus response, TLR signaling, interferon/IL-6 regulation) and various developmental/neural processes (bone development, myelination, neuronal migration, imaginal disc polarity, kidney development) with no clear common function or strong connectivity among the proteins. The lack of edges/triangles also suggests no cohesive functional module. Therefore, there isn\u2019t a single coherent theme to label this cluster; Unknown with None.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0034162","count":2},{"id":"GO:0045410","count":2},{"id":"GO:0090141","count":2}]},{"hash":"736344372887935228","title":"Embryonic morphogenesis and immune cell trafficking","description":"The top GO terms point to diverse developmental processes (cartilage condensation, neural crest migration, metanephric/lymphatic/neuronal development) alongside immune-related activities (phagocytosis recognition, leukocyte tethering/rolling, response to fungal molecules). This suggests a broad theme of tissue morphogenesis with concurrent immune cell interactions, rather than a single, cohesive pathway, hence a descriptive label that captures both aspects. ","confidence":"Medium","size":15,"edges":12,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0036486","count":2},{"id":"GO:0072177","count":2},{"id":"GO:0072218","count":2}]},{"hash":"1021617363473244561","title":"Neural development and MAPK signaling","description":"The terms cluster around neural and organismal development (forebrain development, neural tube closure, skeletal development) and ERK/MAPK signaling with angiogenesis, pointing to a developmentally focused program rather than immune or aging processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0070374","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0001501","count":4}]},{"hash":"2143149880963157819","title":"Lectin and Fc receptor\u2013driven innate immune activation","description":"The cluster is enriched for innate immune signaling terms, including complement activation via the lectin pathway, C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, and phagocytosis recognition, suggesting a coherent role in pathogen recognition and effector responses such as phagocytosis and adhesion. Some non-immune terms appear as secondary annotations, but the dominant theme is lectin- and Fc-mediated innate immunity.","confidence":"High","size":15,"edges":20,"triangles":3,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":15},{"id":"GO:0072237","count":13},{"id":"GO:0071226","count":13},{"id":"GO:0045575","count":13},{"id":"GO:0002223","count":13}]},{"hash":"1835518617626103118","title":"ECM remodeling and angiogenesis","description":"The proteins group around extracellular matrix organization (collagen fibril organization, elastic fiber assembly), cell-matrix adhesion, and vascular-related processes (angiogenesis, proteoglycan biosynthesis), pointing to an ECM remodeling and vascular development theme. A peripheral immune reference (complement activation) is present but secondary.","confidence":"High","size":15,"edges":25,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0030199","count":6},{"id":"GO:0007160","count":5},{"id":"GO:0034116","count":4},{"id":"GO:0051005","count":4}]},{"hash":"2004407485246334091","title":"LDL receptor endocytosis regulation","description":"This cluster is dominated by GO terms about negative regulation of LDL receptor activity/binding, receptor-mediated endocytosis in cholesterol transport, and related receptor recycling processes, pointing to a shared role in controlling cholesterol uptake via LDL receptor pathways. A few terms pertain to protein processing and development, which are less central to the main theme.","confidence":"High","size":15,"edges":26,"triangles":2,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1905598","count":4},{"id":"GO:0090472","count":4},{"id":"GO:1905596","count":4},{"id":"GO:0030435","count":4},{"id":"GO:0032804","count":4}]},{"hash":"1855493178966556202","title":"Dopaminergic Signaling and Visual Processing","description":"This cluster shows strong representation of neural signaling terms: dopaminergic synaptic transmission, visual perception/learning, and cocaine-related behavioral responses, along with ERK cascade regulation and protein phosphorylation, all pointing to neuronal signal transduction and sensory processing pathways. The heart development and prostaglandin response terms may reflect pleiotropy or shared signaling components, but the dominant theme centers on neural communication and visual processing.","confidence":"Medium","size":15,"edges":76,"triangles":194,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0001963","count":9},{"id":"GO:0071380","count":9},{"id":"GO:0010759","count":9}]},{"hash":"1240461042256610113","title":"Unknown","description":"The GO terms for this cluster are highly heterogeneous, spanning plant development (axillary shoot meristem initiation, regulation of secondary shoot formation), basic cellular processes (cell division, ribosomal subunit assembly), metabolism (fermentation, thiamine biosynthesis), and even unrelated annotations (hippocampus development, hemidesmosome assembly). This lack of a cohesive functional theme makes it hard to assign a meaningful, representative label.","confidence":"","size":15,"edges":16,"triangles":2,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:1903212","count":2},{"id":"GO:2001172","count":2},{"id":"GO:0090180","count":2},{"id":"GO:0021766","count":2}]},{"hash":"930867197731260847","title":"Developmental signaling and morphogenesis","description":"This cluster\u2019s top GO terms span GPCR acetylcholine receptor signaling, receptor clustering, and multiple organ morphogenesis processes (placental branching, kidney glomerular and proximal tubule development), plus neuronal migration and axon guidance, and cell\u2013cell adhesion. Together they point to proteins involved in developmental signaling and tissue morphogenesis across neural and organ contexts, rather than a single, tightly focused function. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007213","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0060672","count":2},{"id":"GO:0007567","count":1},{"id":"GO:0072274","count":1}]},{"hash":"858925188899966519","title":"Glycosylation and glycan biosynthesis","description":"Top terms cluster around glycosylation and glycan metabolism, including N-linked glycosylation, N-glycan processing, oligosaccharide metabolism, protein sialylation, and ganglioside biosynthesis. Though pollen tube growth and olfactory development terms appear, the strongest common theme is glycan assembly and modification on proteins and lipids that mediate cell surface interactions.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009860","count":3},{"id":"GO:0009311","count":3},{"id":"GO:0018279","count":3},{"id":"GO:0001574","count":3},{"id":"GO:0021628","count":3}]},{"hash":"570688200680625252","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0034260","count":6},{"id":"GO:0006469","count":6},{"id":"GO:0045723","count":5},{"id":"GO:0007568","count":5}]},{"hash":"596525569148011821","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":77,"triangles":195,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":2},{"id":"GO:0048025","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0048024","count":1},{"id":"GO:0033129","count":1}]},{"hash":"763930567500334656","title":"Developmental signaling and differentiation","description":"The terms indicate a focus on developmental signaling pathways (Notch, TGF-\u03b2) and differentiation processes in neural and cardiac lineages (nervous system development, radial glial differentiation, EMT in endocardial cushion formation), with supporting processes like ubiquitin-mediated turnover and cell-cycle components, suggesting a cohesive theme of development-driven differentiation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0051409","count":2}]},{"hash":"1103391424179004619","title":"Large subunit ribosome biogenesis","description":"The GO terms that recur are centered on ribosome formation, especially the large subunit: ribosomal large subunit assembly, maturation of LSU-rRNA, LSU export from the nucleus, and preribosome large subunit assembly, indicating a cohesive function in large subunit biogenesis. Some outlier terms (NF-kappaB signaling and methionine salvage) appear but are not representative of the main cluster signal. Medium","confidence":"","size":15,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007249","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0009088","count":2}]},{"hash":"2280792469126788738","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":21,"triangles":16,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000472","count":5},{"id":"GO:0042273","count":5},{"id":"GO:0000480","count":5},{"id":"GO:0000184","count":4},{"id":"GO:0000398","count":4}]},{"hash":"1434138422448725026","title":"Cardiac development and TGF-\u03b2 signaling","description":"The Top Terms include cardiac ventricle development and ductus arteriosus closure, plus positive regulation of the TGF-\u03b2 receptor signaling pathway, suggesting a core theme of heart development and growth/regulatory signaling. There are also terms related to transcription regulation and ncRNA-mediated silencing, which may reflect regulatory layers accompanying development, but the strongest cohesive signal is heart formation and TGF-\u03b2 pathway activity.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0031047","count":2},{"id":"GO:0032208","count":2},{"id":"GO:0030511","count":2},{"id":"GO:0003257","count":2}]},{"hash":"644823082385966917","title":"Neurodevelopment and synapse formation","description":"Top terms include nervous system development and synapse assembly, with actin filament binding regulation suggesting cytoskeletal remodeling for synapse formation. While some terms touch on cell division and metabolism, the prevailing signal points to neural development and connectivity.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060670","count":3},{"id":"GO:0046626","count":3},{"id":"GO:0045737","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0033601","count":2}]},{"hash":"285987438303302023","title":"Embryonic craniofacial and endocrine development","description":"Many top GO terms point to craniofacial (roof of mouth, cartilage morphogenesis), mesodermal, and endocrine organ development (thyroid gland, endocrine system), plus EMT-related heart development. While some general expression terms appear, the dominant theme is embryonic tissue/organogenesis, supporting this as a coherent cluster label.","confidence":"High","size":15,"edges":17,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":15},{"id":"GO:0030878","count":11},{"id":"GO:0000398","count":9},{"id":"GO:0042542","count":9},{"id":"GO:0035270","count":9}]},{"hash":"1318308575631221988","title":"Transmembrane Ion and Substrate Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of ions (sodium, potassium), small molecules and xenobiotics (nitrite, nitrate, sialic acid, 4-hydroxyphenylacetate), and even vesicular neurotransmitter loading, pointing to membrane transporter proteins with varied substrates. The diversity of transport-related terms, all centered on moving substances across membranes, justifies a label around membrane transporters as the cohesive function of the group.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0015707","count":3},{"id":"GO:0006855","count":3},{"id":"GO:1900754","count":3}]},{"hash":"1594878266709339790","title":"Golgi Vesicle Trafficking","description":"The top GO terms are centered on transport related to the Golgi apparatus and ER-to-Golgi pathways (ER to Golgi vesicle transport, intra-Golgi transport, Golgi ribbon formation, Golgi to vacuole transport, and Golgi disassembly), with additional terms touching exocytic insertion and related trafficking processes. This suggests a cohesive cluster of proteins involved in Golgi-mediated vesicle trafficking and sorting of cargo, so a label focusing on Golgi transport is appropriate.","confidence":"High","size":15,"edges":42,"triangles":0,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006888","count":7},{"id":"GO:0048280","count":7},{"id":"GO:0090161","count":7},{"id":"GO:0006896","count":7},{"id":"GO:0006891","count":7}]},{"hash":"920420498255431697","title":"Flavonoid and Lignin Biosynthesis","description":"The top GO terms cluster around biosynthesis of flavonoids and lignin, including anthocyanins, kaempferol/quercetin glucosides, and cyanidin glucoside, as well as lignin metabolism, all core components of the phenylpropanoid pathway. Additional terms about antibiotic biosynthesis and lipopolysaccharide response may reflect defense-related metabolites or annotation noise, and one term about paranode localization is likely unrelated. Overall, the dominant signal points to production of plant secondary metabolites via flavonoid and lignin biosynthesis.","confidence":"High","size":15,"edges":24,"triangles":21,"max_degree":9,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0017000","count":9},{"id":"GO:0032496","count":6},{"id":"GO:0009718","count":6},{"id":"GO:0033330","count":5}]},{"hash":"1431118293925307020","title":"Central Metabolism and Amino Acid Biosynthesis","description":"This cluster is dominated by core metabolic processes: multiple TCA-cycle\u2013related terms (tricarboxylic acid cycle, isocitrate, 2-oxoglutarate) plus several amino acid biosynthesis pathways (leucine, lysine, glutamate) and related cofactor synthesis (glutathione, protoporphyrinogen IX). These align to a coherent theme of central carbon metabolism and amino acid/porphyrin biosynthesis, with a couple of outlier regulatory terms that are unlikely to define the overall function. ","confidence":"High","size":15,"edges":58,"triangles":121,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":6},{"id":"GO:0006099","count":5},{"id":"GO:0006103","count":4},{"id":"GO:0006749","count":4},{"id":"GO:0006537","count":4}]},{"hash":"316823416789779625","title":"Developmental regulation and tissue morphogenesis","description":"The top GO terms cluster around development and morphogenesis across multiple tissues (neural retina development, synapse assembly, skeletal system development, endocardial differentiation, smooth muscle proliferation, hyaluronan biosynthesis, etc.), suggesting a shared theme of developmental regulation rather than a single focused pathway. Some terms related to immune signaling or ATP response are present but do not override the overarching developmental pattern; hence a broad developmental/tissue morphogenesis label is appropriate.","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0061074","count":15},{"id":"GO:0071318","count":15},{"id":"GO:0044537","count":15},{"id":"GO:0007416","count":15},{"id":"GO:0060488","count":15}]},{"hash":"1043916358588185996","title":"Neuronal development and mitochondrial transport","description":"The terms cluster around brain development (cerebellum development, hypothalamus differentiation) and synaptic function (GABAergic transmission), reinforced by mitochondrial transport in axons and dendrites, plus translational regulation associated with neuronal activity. This suggests a coherent theme of neuronal maturation, synaptic regulation, and mitochondrial trafficking within neurons.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000766","count":3},{"id":"GO:0060211","count":2},{"id":"GO:0098957","count":2},{"id":"GO:0032901","count":2},{"id":"GO:0007287","count":2}]},{"hash":"225451327360558202","title":"Transmembrane Transporters","description":"The top GO terms reflect diverse transmembrane transport activities: sodium and potassium ion transport, nitrite/nitrate transport and assimilation, xenobiotic and sialic acid transport, as well as neurotransmitter loading into synaptic vesicles. Together these terms point to a coherent cluster of membrane transport proteins that move ions and small molecules across membranes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":5},{"id":"GO:0015707","count":3},{"id":"GO:0006855","count":3},{"id":"GO:1900754","count":3}]},{"hash":"805141848871275277","title":"Glycan Biosynthesis and Processing","description":"The cluster is dominated by GO terms tied to glycan construction and modification, including N-linked glycosylation via asparagine, N-glycan processing, protein sialylation, ganglioside biosynthesis, and various oligosaccharide metabolic processes. This suggests a cohesive theme of glycan biosynthesis and remodeling on glycoproteins and glycolipids, underlying secretory pathways and potentially influencing pollen tube growth and pollen germination through glycoprotein-modulated cell walls. While some terms reflect animal neural development, the common thread remains glycan metabolism across contexts.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009860","count":6},{"id":"GO:0009311","count":6},{"id":"GO:0018279","count":6},{"id":"GO:0001574","count":6},{"id":"GO:0021628","count":6}]},{"hash":"456043015299404745","title":"Endothelial adhesion and angiogenesis regulation","description":"These terms cluster around endothelial cell interactions and vascular formation: cell-matrix adhesion, heterophilic cell-cell adhesion, VEGF signaling, and both positive and negative regulation of angiogenesis and endothelial chemotaxis. Immune signals (complement activation via lectin pathway, IL-4 production) and extracellular matrix remodeling (hyaluronan biosynthesis) suggest immune-ECM coordination during vessel development. Thyroid hormone generation is less directly linked but may reflect broader developmental context. Overall, the core theme is endothelial adhesion and angiogenesis regulation.","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":14,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0007160","count":11},{"id":"GO:0006590","count":11},{"id":"GO:0007157","count":11},{"id":"GO:1900748","count":8}]},{"hash":"1274987741984285266","title":"Innate and Adaptive Immune Signaling","description":"This cluster's top GO terms are dominated by immune-related processes, including innate immune response, adaptive immune response, B cell receptor signaling, interleukin-2 production, and NF-kappaB activity, pointing to shared roles in immune signaling and regulation. Other terms such as heart development, long-term synaptic plasticity (LTP/LTD), and social behavior appear less consistently and may reflect pleiotropy or annotation breadth, but the strongest common theme across the proteins is involvement in immune signaling pathways.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0043552","count":5},{"id":"GO:1900273","count":5},{"id":"GO:0050853","count":5}]},{"hash":"1317589874011163880","title":"ER stress and protein folding response","description":"Top terms center on ER stress, unfolded protein response, and protein folding, with PPIase activity and stress-induced translation regulation. Less specific terms (lead ion response, interferon signaling) point to broader cellular stress interactions. Overall, the cluster resembles ER stress\u2013driven protein quality control.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0071357","count":9},{"id":"GO:0010288","count":9},{"id":"GO:0070301","count":9},{"id":"GO:0036494","count":9},{"id":"GO:0031145","count":9}]},{"hash":"1094261938163509860","title":"Mitochondrial Cristae Formation and Intermembrane Import","description":"The cluster is dominated by GO terms for mitochondrial cristae formation, and protein import into the mitochondrial intermembrane space, plus mitochondrial calcium ion homeostasis, which strongly points to mitochondrial biogenesis and function as the core theme. Other terms (mitotic cycle, cytokinesis regulation, NF-kappaB signaling, phosphorylation, and development) likely reflect broader regulatory roles or secondary associations, but do not override the mitochondria-centric signal. Overall, the main functional thread is mitochondrial structure and protein handling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042407","count":3},{"id":"GO:0045041","count":3},{"id":"GO:0051560","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0032465","count":2}]},{"hash":"226634624451057483","title":"Unknown","description":"The GO terms are diverse, spanning transcription, ribosome biogenesis, splicing, cytoskeletal dynamics, signaling, transport, and development, with no single dominant function tying the proteins together; along with zero edges, this cluster does not show a coherent shared biological theme.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0007584","count":1},{"id":"GO:0048705","count":1}]},{"hash":"1353237179032174546","title":"Vertebrate Development and Ciliogenesis","description":"This cluster's GO terms prominently include mitotic cell cycle, multicellular organism development, neural tube closure, skeletal system development, and cilium assembly, suggesting roles in embryonic development and ciliogenesis. Other terms indicate transcriptional regulation during development and cellular stress signaling, with a few immune-defense terms as secondary themes. Overall, the dominant theme is development with cilium-related functions, hence the label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0001403","count":6},{"id":"GO:0001501","count":6},{"id":"GO:0070059","count":6}]},{"hash":"1377787396385685459","title":"Ubiquitin-dependent immune regulation","description":"This cluster is led by ubiquitin-dependent protein catabolic process, with multiple immune-related terms such as pro-T cell differentiation, type 2 immune response, memory T cell differentiation, and regulation of mast cell cytokine production. These patterns suggest a theme of proteostasis coupled to immune signaling and lymphocyte differentiation. Some terms like sarcomere organization or distal tubule morphogenesis may reflect broader cellular maintenance roles or annotation noise, but the dominant signal points to ubiquitin-mediated regulation of immune cell function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0048294","count":6},{"id":"GO:2000176","count":6},{"id":"GO:0042092","count":6},{"id":"GO:0009958","count":6}]},{"hash":"281808256114625737","title":"Nucleotide and vitamin biosynthesis with tRNA modifications","description":"The top GO terms cluster around biosynthetic processes for NAD+, thiamine, GMP, and thiazole, plus tRNA thio-modification and wobble uridine thiolation, suggesting a shared theme of nucleotide/vitamin biosynthesis and RNA modification. Sporulation terms appear but are minor and not defining the group. Overall, this points to a metabolic module focused on biosynthesis and tRNA modification rather than a single pathway. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009435","count":1},{"id":"GO:0034227","count":1},{"id":"GO:0009229","count":1},{"id":"GO:0006541","count":1},{"id":"GO:0006177","count":1}]},{"hash":"783682596564264192","title":"Steroid and lipid mediator biosynthesis","description":"The top GO terms point to lipid metabolism and signaling, including prostaglandin and oxylipin biosynthesis, along with aldosterone biosynthesis and related hormone responses (e.g., vitamin D response, mammary gland development). This suggests a core theme of lipid-derived mediators and steroid hormone pathways driving these proteins\u2019 functions, with some ancillary terms reflecting broader stress or immune signals. Overall, the cluster appears best described by lipid mediator and steroid biosynthesis. ","confidence":"Medium","size":15,"edges":80,"triangles":205,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":15},{"id":"GO:0033076","count":14},{"id":"GO:0031408","count":14},{"id":"GO:0010164","count":14},{"id":"GO:0032342","count":14}]},{"hash":"1907041355300863263","title":"Ion and Metabolite Membrane Transporters","description":"The top GO terms are dominated by transmembrane transport of ions (sodium, potassium, calcium) and metabolites (glucose, amino acids, sialic acid, pantothenate, myo-inositol), plus related export processes, pointing to a cluster of membrane transporter proteins. Some terms (phosphatidylcholine catabolic process, acetylcholine biosynthetic process) are peripheral but do not negate the overall transport-focused theme. Confidence: High","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0015739","count":2},{"id":"GO:0032973","count":2},{"id":"GO:1990034","count":2}]},{"hash":"2153119259791311361","title":"Unknown","description":"The set includes GPCR-cAMP signaling and blood pressure regulation terms, but also electron transport chain, immune (IL-1\u03b2 production, dendritic cell differentiation), photoreceptor maintenance, and temperature response terms. This broad mix suggests no single cohesive biological theme tying the proteins together, so a general Unknown label is most appropriate.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0035025","count":11},{"id":"GO:0007190","count":11}]},{"hash":"1458113673791471328","title":"Drosophila ovarian follicle cell polarity and adhesion","description":"The prominent GO terms center on egg chamber development in insects, especially the polarity and adhesion of follicle epithelium and the follicle cell\u2013egg chamber context, suggesting a cohesive role in Drosophila oogenesis and epithelial morphogenesis. Some terms appear unrelated (metabolic or general development), which may reflect off-target annotations, but the strongest signal aligns with ovarian follicle morphogenesis and epithelial polarity.","confidence":"Medium","size":15,"edges":14,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":5},{"id":"GO:0001744","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0007299","count":4},{"id":"GO:0005980","count":3}]},{"hash":"18986846626111731","title":"Cardiac and skeletal muscle differentiation","description":"The top terms cluster around development of muscle and heart structures: myoblast differentiation, coronary artery morphogenesis, EMT in endocardial cushion formation, and SHH pathway regulation, all pointing to a developmental program for muscle and cardiac tissue. Some terms like complement activation and trophoblast differentiation are less connected, suggesting peripheral edges rather than core functions of this cluster.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0045880","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0045445","count":2}]},{"hash":"1322980767406151477","title":"Translation initiation and mRNA surveillance","description":"This cluster is enriched for GO terms related to translation initiation and RNA quality control, including eukaryotic translation initiation factor 3 complex assembly, formation of the cytoplasmic translation initiation complex, and nuclear mRNA surveillance, suggesting a shared role in initiating protein synthesis and monitoring mRNA integrity. The presence of a few unrelated biosynthesis terms appears as noise but does not override the dominant RNA-processing/translation theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":2},{"id":"GO:0009239","count":1},{"id":"GO:0019878","count":1},{"id":"GO:0042759","count":1},{"id":"GO:0070196","count":1}]},{"hash":"2288848554356083181","title":"Cytokine and Chemokine Immune Signaling","description":"The proteins cluster around immune-related processes, including positive regulation of dendritic cell differentiation, chemokine production, and IL-6 production, indicating involvement in cytokine/chemokine signaling and immune cell communication. Additional terms related to erythropoietin signaling and responses to glycoproteins suggest a broader hematopoietic signaling context but do not override the primary immune signaling theme. Thus, a label focusing on cytokine/chemokine signaling best captures the cluster\u2019s function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0008015","count":1},{"id":"GO:0000060","count":1}]},{"hash":"395415691069622254","title":"Telomere Regulation and Differentiation","description":"Based on the top GO terms, the cluster centers on telomere maintenance/capping via telomerase and differentiation processes (oligodendrocyte and fat cell differentiation), with supporting signals such as vitamin D response, cell migration, and RNA processing. This suggests the proteins may coordinate genome stability with lineage differentiation programs rather than a single narrow function,Justifying a label that reflects both telomere regulation and differentiation potential.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0048709","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0035994","count":3}]},{"hash":"1790219371150085038","title":"IL-4\u2013driven B cell activation and IgE class switching","description":"The top GO terms cluster around B cell\u2013related signaling and IgE isotype switching (regulation of B cell receptor signaling, isotype switching to IgE) with IL-4\u2013mediated signaling. Actin cytoskeleton reorganization and cell\u2013cell adhesion support receptor signaling and immune cell activation, reinforcing a B cell\u2013centric activation program. While a few terms reference broader signaling contexts, the dominant pattern is IL-4\u2013driven B cell activation and IgE class switching.","confidence":"High","size":14,"edges":16,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":9},{"id":"GO:1904531","count":9},{"id":"GO:0048295","count":9},{"id":"GO:0046676","count":9},{"id":"GO:0050859","count":9}]},{"hash":"1107497131151344658","title":"Calcineurin-NFAT signaling in development and immunity","description":"GO terms strongly point to the calcineurin-NFAT axis (regulation of calcineurin-NFAT signaling cascade) with immune roles (T cell homeostasis, negative regulation of T cell cytotoxicity) and developmental contexts (heart development, EMT). The glucocorticoid response also intersects NFAT signaling, supporting an NFAT-centered theme spanning immunity and development. Some terms (ascospore formation, potassium channel clustering) may be peripheral noise, but the core pattern supports NFAT-driven signaling as the cluster\u2019s unifying function.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0008284","count":2},{"id":"GO:0045163","count":2},{"id":"GO:0001915","count":2},{"id":"GO:0051384","count":2}]},{"hash":"1370366883463962904","title":"Cytoskeleton remodeling and cell migration","description":"The dominant GO terms point to actin cytoskeleton reorganization, nuclear and spindle dynamics, and vesicle/mitochondrial transport along microtubules, all of which underpin cytoskeletal remodeling and intracellular movement during cell division and migration. Additionally, terms related to wound healing, mast cell degranulation, and macrophage differentiation suggest immune-related roles that often rely on dynamic cytoskeletal changes. Overall, the cluster seems driven by cytoskeletal dynamics and intracellular transport that coordinate movement, division, and immune signaling. ","confidence":"High","size":14,"edges":7,"triangles":1,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043124","count":14},{"id":"GO:1902307","count":14},{"id":"GO:0031532","count":14},{"id":"GO:0007097","count":14},{"id":"GO:0044319","count":14}]},{"hash":"564064106118474437","title":"Calcium-Mediated Immune Defense","description":"The GO terms cluster around innate immune activation (defense against bacteria, LPS response, xenobiotic/stress response) and calcium signaling (calcium release into cytosol, regulation of membrane potential), with related processes like intracellular transport and cytolysis to support stress responses. This suggests a cohesive role for calcium-enabled signaling in defense and stress responses.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0042391","count":3},{"id":"GO:0042742","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0019835","count":3}]},{"hash":"2154883061203795992","title":"Embryonic organogenesis and innate immunity","description":"This cluster combines GO terms pointing to organ development processes such as metanephric kidney development (ascending thin limb, proximal tubule) and lymph vessel morphogenesis, with immune-related terms like phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and stimulatory C-type lectin receptor signaling. The mix suggests proteins involved in developmental remodeling that also engage innate immune signaling pathways, making a label centered on both organogenesis and innate immunity appropriate.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":13},{"id":"GO:0072177","count":12},{"id":"GO:0006910","count":12},{"id":"GO:0050901","count":12},{"id":"GO:0036303","count":12}]},{"hash":"186026023003939963","title":"Synaptic vesicle trafficking and neuronal development","description":"The strongest terms point to synaptic transmission and vesicle cycling (regulation of synaptic vesicle exocytosis/endocytosis, endocytic recycling, excitatory postsynaptic potential), suggesting a neural synaptic function cluster. Brain development term (substantia nigra development) supports a neuronal context, while ossification in bone maturation appears as a weaker outlier. ","confidence":"High","size":14,"edges":43,"triangles":71,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":12},{"id":"GO:0021762","count":12},{"id":"GO:0035690","count":12},{"id":"GO:0060079","count":12},{"id":"GO:2000300","count":12}]},{"hash":"2079003323514522197","title":"Ubiquitin-ERAD Regulation and Microtubule Transport","description":"This cluster centers on ubiquitin-dependent ERAD processes and their regulation (negative regulation of ERAD and deubiquitination) together with plus-end\u2013directed vesicle transport along microtubules, suggesting a coherent theme of ubiquitin-mediated protein quality control at the ER linked to trafficking. Lipid droplet organization and related signaling terms hint at ER-lipid associations, reinforcing the ER-adjacent functional context. While several terms are obsolete, the core pattern points to ERAD/ubiquitin signaling coupled with microtubule-based transport.","confidence":"Medium","size":14,"edges":87,"triangles":320,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0072383","count":3},{"id":"GO:1904293","count":2},{"id":"GO:1903094","count":2},{"id":"GO:0008219","count":2}]},{"hash":"146290093748110564","title":"Embryonic organ morphogenesis and immune processes","description":"This cluster is enriched for terms related to embryonic development and organ morphogenesis (mesonephric duct, metanephric tubule development, lymph vessel morphogenesis, cartilage condensation), with additional immune-related terms (phagocytosis recognition, leukocyte tethering/rolling, basophil activation, response to fungal origin) suggesting a broad developmental-immune functional theme. The absence of network edges makes the connection broad rather than tightly cohesive, so the label is representative but not tightly specific.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0072177","count":5},{"id":"GO:0006910","count":5},{"id":"GO:0072218","count":5},{"id":"GO:0050901","count":5},{"id":"GO:0036303","count":5}]},{"hash":"368000000912121050","title":"Epithelial Morphogenesis and Signaling","description":"This cluster centers on epithelial development and tissue remodeling, highlighted by keratinocyte development, epithelial morphogenesis, and wound healing, along with related cell-adhesion and signaling processes (integrin signaling, semaphorin-plexin signaling). While some terms touch broader signaling (dopamine receptor pathways, miRNA metabolism) and an organism-specific term (pollen sperm differentiation), the dominant theme ties cell shape, adhesion, and developmental remodeling together through signaling networks. Confidence: Medium","confidence":"","size":14,"edges":52,"triangles":104,"max_degree":12,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0003334","count":7},{"id":"GO:1905000","count":7},{"id":"GO:0003382","count":7},{"id":"GO:0048235","count":7},{"id":"GO:0072089","count":7}]},{"hash":"496226496217917730","title":"Immune Signaling with Actin Remodeling","description":"The terms show a clear focus on immune-related processes (IL-12 response, self-antigen tolerance, mast cell degranulation) together with cytoskeletal dynamics (actin reorganization, actin filament binding) and apoptosis (programmed cell death, anoikis, FGFR apoptotic signaling). This points to a theme where immune signaling is linked to actin remodeling and apoptotic regulation.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":12},{"id":"GO:0031532","count":12},{"id":"GO:1904531","count":12},{"id":"GO:2000811","count":12},{"id":"GO:0002651","count":12}]},{"hash":"1982112601337530957","title":"Actin cytoskeleton remodeling and cell polarity","description":"The cluster is dominated by GO terms tied to actin dynamics and polarity, notably Arp2/3 complex\u2013mediated actin nucleation, actin cortical patch assembly, and establishment/maintenance of cell polarity, pointing to a cohesive theme of cytoskeletal remodeling and cell shape regulation. Some terms mention organelle inheritance and development that seem less central, but the core signal is actin-driven cytoskeleton organization and polarity control.","confidence":"High","size":14,"edges":87,"triangles":320,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0071963","count":8},{"id":"GO:0000011","count":8},{"id":"GO:0000001","count":8},{"id":"GO:0000147","count":8},{"id":"GO:0016344","count":7}]},{"hash":"1590762783514363279","title":"Spliceosome Regulation of mRNA Processing","description":"The cluster is dominated by GO terms tied to regulation of mRNA splicing via the spliceosome (positive and negative regulation, alternative splicing), along with related RNA-processing activities such as small-subunit processome assembly, mRNA modification, and stabilization. This convergence suggests a cohesive function in post-transcriptional RNA processing centered on splicing control, with some developmental context indicated by blastocyst formation terms.","confidence":"High","size":14,"edges":47,"triangles":99,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":10},{"id":"GO:0000381","count":10},{"id":"GO:0048026","count":10},{"id":"GO:0001825","count":9},{"id":"GO:1900363","count":9}]},{"hash":"1410612454056823863","title":"Fatty acid elongation and retinoid biosynthesis","description":"The cluster is enriched for fatty acid biosynthetic processes, including elongation, very long-chain and methyl-branched fatty acids, and retinoic acid biosynthesis. These lipid pathways are linked to development (lung development) and transcription regulation via retinoid signaling, suggesting a coherent lipid metabolism and signaling theme. Some terms (poly-hydroxybutyrate biosynthetic process, response to methotrexate) are outliers but do not overturn the main pattern.","confidence":"Medium","size":14,"edges":15,"triangles":6,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":9},{"id":"GO:0055114","count":9},{"id":"GO:0030324","count":7},{"id":"GO:0006355","count":7},{"id":"GO:0009710","count":7}]},{"hash":"641875545946898152","title":"RNA processing and ribosome biogenesis regulation","description":"The terms cluster around RNA metabolism and processing (polyadenylation, mRNA export, splicing regulation, stabilization) with involvement of helicase/ATP-dependent activities and ribosome biogenesis, plus regulatory ncRNA-mediated gene silencing and a developmental term (blastocyst formation). This suggests a cohesive theme of RNA maturation control and ribosome assembly impacting gene expression, hence the proposed label.","confidence":"High","size":14,"edges":16,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":3},{"id":"GO:0051096","count":3},{"id":"GO:0016973","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0001825","count":2}]},{"hash":"1800541860446981351","title":"Synaptic Exocytosis and Secretion Regulation","description":"These proteins cluster around exocytosis and secretion processes, especially synaptic vesicle exocytosis, neurotransmitter transport, and regulation of neurotransmitter release, with an additional note on insulin secretion. While there are some RNA processing/export terms present, the strongest and most coherent signal is vesicle trafficking and regulated secretion in neuronal contexts, justifying a label focused on synaptic exocytosis and secretion. ","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016079","count":1},{"id":"GO:0046928","count":1},{"id":"GO:0006836","count":1},{"id":"GO:0031915","count":1},{"id":"GO:0030073","count":1}]},{"hash":"530511059388253258","title":"Neuronal signaling and synapse organization","description":"The cluster is dominated by GO terms tied to neurotransmitter signaling (acetylcholine, GABA, serotonin), postsynaptic membrane organization, and regulation of nerve impulse transmission, pointing to synaptic function and receptor clustering. Behavioral terms like startle response and walking behavior suggest involvement in neural circuits underlying movement and reflexes, with additional hints from vestibulocochlear nerve development. Overall, the proteins likely participate in synaptic signaling and the organization of the postsynaptic apparatus.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0051970","count":13},{"id":"GO:0001661","count":13},{"id":"GO:0095500","count":13},{"id":"GO:0001964","count":13},{"id":"GO:0007628","count":13}]},{"hash":"1318707307032167836","title":"Unknown","description":"The Top Terms show a broad mix of processes including axon guidance, GTPase signaling, platelet activation, metabolism (cellulose catabolic process), immune signaling (IL-6 production), renal and cardiac development, epithelial polarity, and temperature response. The lack of a clear, shared biological theme across the cluster suggests there isn't a single coherent function tying all members together, so Unknown is the appropriate label.","confidence":"","size":14,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048846","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0030245","count":2},{"id":"GO:0071502","count":1}]},{"hash":"2259833662668953009","title":"Bacterial carbohydrate metabolism and redox cofactor biosynthesis","description":"The cluster is dominated by carbohydrate-related terms (glucose metabolic process, starch biosynthetic process, response to sucrose) and terms for biosynthesis of bacillithiol and mycothiol, which are redox cofactors characteristic of bacteria. This suggests a metabolic program centered on carbohydrate processing with associated redox defense systems. Some outlier terms (e.g., feeding behavior, response to flooding) appear, but they do not overwhelm the core metabolic theme.","confidence":"Medium","size":14,"edges":48,"triangles":55,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006006","count":7},{"id":"GO:0050830","count":5},{"id":"GO:0007631","count":5},{"id":"GO:0033577","count":5},{"id":"GO:0071793","count":5}]},{"hash":"762559602294208936","title":"Neural development and synapse assembly","description":"This cluster is dominated by neural development terms\u2014neurogenesis, nervous system development, myelination, and especially positive regulation of synapse assembly and clustering of voltage-gated sodium channels\u2014indicating proteins involved in neuronal differentiation and synaptic maturation. Although terms like collagen fibril organization and angiogenesis are present, the strongest signal points to neural development and synaptic organization.","confidence":"High","size":14,"edges":72,"triangles":202,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":10},{"id":"GO:0045663","count":10},{"id":"GO:0022008","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0045162","count":10}]},{"hash":"412357613178667085","title":"Glycosaminoglycan and Small-Molecule Metabolism","description":"The top GO terms cluster around glycosaminoglycan biosynthesis (heparan sulfate, chondroitin sulfate, dermatan sulfate) and sulfate assimilation, plus several broad small-molecule metabolism terms (xenobiotic, thyroid hormone, catecholamine, flavonoid, bile acid, N-acetylglucosamine). This pattern suggests a metabolic cluster with roles in processing sulfated polysaccharides and a variety of metabolites rather than a single highly specific pathway.","confidence":"Medium","size":14,"edges":11,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":10},{"id":"GO:0030206","count":10},{"id":"GO:0000103","count":9},{"id":"GO:0030573","count":8},{"id":"GO:0006044","count":8}]},{"hash":"869094543997794680","title":"Chromatin remodeling and transcription regulation","description":"The top GO terms cluster around transcription control and chromatin dynamics, including DNA-templated transcription, negative regulation of RNA Pol II transcription, and chromatin remodeling, which together point to a cohesive theme of chromatin state influencing transcription. While several developmental and obsolete terms appear, the dominant signal is chromatin regulation of transcription.","confidence":"Medium","size":14,"edges":24,"triangles":14,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060303","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0043044","count":6},{"id":"GO:0048752","count":5}]},{"hash":"2289633442385085931","title":"Immune Regulation and Epigenetic Control","description":"This cluster combines immune-related terms (response to vitamin D, T cell homeostasis, negative regulation of T-helper cell differentiation, negative regulation of necroptotic process) with epigenetic modulation terms (histone catabolic process, histone acetylation regulation), suggesting a set of proteins involved in immune signaling and transcriptional/epigenetic control. Some ubiquitination-related terms and peptide processing hints reflect broader protein regulation that supports these pathways. Overall, the theme points to immune regulation intertwined with chromatin-level control.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033280","count":13},{"id":"GO:0030433","count":11},{"id":"GO:0045623","count":10},{"id":"GO:0036205","count":10},{"id":"GO:0043029","count":10}]},{"hash":"1774322925775353079","title":"Mitochondrial Transporters and Membrane Potential Regulation","description":"The top GO terms point to mitochondrial transport across membranes (citrate, ornithine, thiosulfate, ATP) and regulation of mitochondrial membrane potential, with supporting terms about metabolic stress responses and insulin signaling. This combination suggests a cohesive group of mitochondrial transporter/metabolic proteins rather than unrelated functions, justifying a focused label on mitochondrial transport and membrane energetics.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":3},{"id":"GO:0015886","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0000066","count":3},{"id":"GO:0097421","count":3}]},{"hash":"2035823777024498902","title":"Cardiac conduction and heart rate regulation","description":"The top GO terms cluster around heart rhythm control and electrical activity, including regulation of heart rate by cardiac conduction, AV node action potential, and membrane depolarization/repolarization in atrial and ventricular cardiomyocytes. Some development terms appear but are secondary; overall the theme centers on cardiac electrophysiology.","confidence":"High","size":14,"edges":13,"triangles":0,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0086091","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0060307","count":5},{"id":"GO:0060371","count":5},{"id":"GO:0001822","count":5}]},{"hash":"573773361796401408","title":"Retinoid and small-molecule metabolism","description":"This cluster is dominated by GO terms for retinol and retinoic acid metabolism, along with several other small-molecule biosynthetic and catabolic processes (fructose, fatty acids, D-xylulose 5-phosphate, and aldehyde detox). The presence of copper ion response is a peripheral note, but the strongest signal is vitamin A-related metabolism and broader small-molecule biosynthesis, making this label representative.","confidence":"Medium","size":14,"edges":42,"triangles":46,"max_degree":12,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0042572","count":8},{"id":"GO:0046370","count":7},{"id":"GO:0042573","count":7},{"id":"GO:0033859","count":7}]},{"hash":"1492613575349847367","title":"NF-kappaB/JNK immune signaling and antiviral defense","description":"Top GO terms cluster around immune signaling and inflammation, with positive regulation of NF-kappaB and JNK cascades, TH1-type responses, and defense against viruses. A few terms touch mechanotransduction and Hedgehog signaling, but the dominant theme is immune regulation and antiviral defense, supporting this label.","confidence":"Medium","size":14,"edges":10,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032707","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0046330","count":5},{"id":"GO:0042088","count":5},{"id":"GO:0051092","count":4}]},{"hash":"705506691527903055","title":"Neural GPCR-cAMP Signaling and Visual Processing","description":"This cluster is dominated by neural signaling terms involving dopamine and adrenergic receptor pathways that activate cAMP and PLC signaling, along with positive regulation of GTPase activity, as well as phototransduction and visual learning, suggesting a cohesive theme of brain signaling and visual processing.","confidence":"High","size":14,"edges":89,"triangles":340,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":11},{"id":"GO:0007191","count":10},{"id":"GO:0007603","count":10},{"id":"GO:0060158","count":10},{"id":"GO:0010513","count":10}]},{"hash":"1562985713716840388","title":"Organogenesis Across Tissues","description":"The top GO terms span multiple organ systems involved in development and morphogenesis (liver, kidney, mesonephric duct, metanephric tubules, cartilage condensation, lymph vessel morphogenesis), suggesting a shared role in organogenesis across tissues; additional general terms like phospholipid homeostasis and gene expression regulation may support developmental regulation but do not define a single tissue-specific process.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":4},{"id":"GO:2000171","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0055091","count":3},{"id":"GO:0010628","count":3}]},{"hash":"874879410424680741","title":"Dopamine\u2013PLC\u2013Rho GPCR signaling cluster","description":"The top GO terms point to GPCR-mediated signal transduction, especially dopamine receptor signaling that activates PLC and Rho GTPase cascades, with positive regulation of GTPase activity and Rho signaling as central themes. Phototransduction and developmental terms likely reflect broader roles of GPCR pathways in sensory signaling and development. Taken together, the cluster seems best described as a GPCR signaling module centered on dopamine receptor\u2013PLC\u2013Rho pathways.","confidence":"Medium","size":14,"edges":77,"triangles":240,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":11},{"id":"GO:0043547","count":9},{"id":"GO:0007266","count":8},{"id":"GO:0001501","count":8},{"id":"GO:0007191","count":8}]},{"hash":"317988231433434005","title":"Immune signaling and cytoskeletal regulation","description":"The terms point to inflammatory and immune signaling (TNF, NF-kappaB, LPS response, B cell receptor signaling) and to cytoskeletal/adhesion processes (integrin signaling, sarcomere organization), with additional links to phagocytosis and growth factor receptor pathways. This suggests a cluster of proteins coordinating immune signaling with cytoskeletal dynamics and cell adhesion.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042347","count":3},{"id":"GO:0034051","count":2},{"id":"GO:0042771","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0033209","count":2}]},{"hash":"527478367789099221","title":"Neuro-immune-vascular signaling regulation","description":"The top GO terms point to regulatory signaling across nervous, immune, and vascular systems, rather than a single pathway. Visual learning and photoreceptor maintenance suggest retinal/nervous functions, while vasopressin-mediated blood pressure regulation, temperature response, and IL-1 beta production regulation indicate neuroendocrine and immune regulation. Additional terms about dendritic cell differentiation, PKA activity, cell proliferation, and blood coagulation reflect broader signaling and homeostatic control across tissues. Together these imply a multisystem signaling/regulatory theme rather than a narrow function. ","confidence":"Medium","size":14,"edges":7,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":7},{"id":"GO:0040015","count":7},{"id":"GO:0045494","count":6},{"id":"GO:0001992","count":6},{"id":"GO:0071502","count":6}]},{"hash":"1165300431479759795","title":"Inflammation and cellular stress regulators","description":"The GO terms point to prostaglandin biosynthesis and inflammatory signaling, with hormonal stress responses (glucocorticoid, insulin, auxin), ROS generation, and suppression of growth signaling like NF-kappaB and ERK cascades, plus p53-mediated DNA damage response. This suggests a cohesive module coordinating inflammation, oxidative stress, and growth control.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":14},{"id":"GO:0032869","count":13},{"id":"GO:0035726","count":13},{"id":"GO:0032930","count":13},{"id":"GO:0043124","count":13}]},{"hash":"1338531385067819535","title":"Cellular metabolism and stress signaling","description":"These proteins pull in several directions: metabolic processes (ethanolamine metabolism, phosphatidylethanolamine biosynthesis, L-threonine biosynthesis), regulatory activities (DNA-templated transcription, phosphorylation), and a stress/death signaling element (ripoptosome assembly in necroptosis). The lack of a single dominant pathway and the presence of both metabolic and regulatory/stress terms suggest a broad cluster involved in core cellular metabolism intertwined with stress response rather than a specific pathway. Confidence: Medium.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901026","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0006580","count":2},{"id":"GO:1904681","count":2}]},{"hash":"579741604640132952","title":"Embryonic Development and Cellular Regulation","description":"The cluster includes GO terms tied to embryonic body morphogenesis, tissue patterning, and organ development (embryonic morphogenesis, chitin-based larval cuticle pattern formation, papilla formation), along with nuclear transport and chromatin remodeling (NLS-bearing protein import into nucleus, transcription initiation-coupled chromatin remodeling) and cytoskeletal organization (intermediate filament bundle assembly). This mix suggests proteins involved in developmental regulation and basic cellular architecture, with some tissue-specific contexts (heart conduction, cuticle formation) but a common thread around development and cellular regulation.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":14},{"id":"GO:0061198","count":13},{"id":"GO:0006607","count":13},{"id":"GO:0048096","count":13},{"id":"GO:0045976","count":13}]},{"hash":"1060268638125900382","title":"Leukocyte adhesion and angiogenic migration","description":"The strongest signals are adhesion-related terms (cell-matrix adhesion, heterophilic cell-cell adhesion) plus leukocyte tethering/rolling and a sprouting angiogenesis\u2013related migration term, pointing to immune cell\u2013endothelial interactions and vascular remodeling. Additional terms reflect inflammatory and immune effector functions (IL-10 production, platelet activation) and complement activation, consistent with a coordinated immune-vascular activation cluster. An outlier term (thyroid hormone generation) may be incidental.","confidence":"Medium","size":14,"edges":14,"triangles":2,"max_degree":5,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007160","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0050901","count":9},{"id":"GO:0090050","count":9},{"id":"GO:0001867","count":9}]},{"hash":"2143461906471371699","title":"Cofactor and tRNA modification biosynthesis","description":"Top GO terms indicate biosynthesis of cofactors (biotin, lipoate) and RNA modification pathways (tRNA queuosine biosynthesis, tRNA methylation) as well as protoporphyrinogen IX biosynthesis, suggesting a cohesive set of proteins dedicated to assembling cellular cofactors and modifying tRNA; a few other biosynthetic processes are present but these core themes are clear.","confidence":"Medium","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0009102","count":1},{"id":"GO:0018339","count":1},{"id":"GO:0019475","count":1}]},{"hash":"1662892274318604728","title":"Xenobiotic Detox and Oxidative Stress","description":"The cluster is dominated by GO terms tied to detoxification and responses to xenobiotics and toxic substances, including xenobiotic stimulus, toxic substance, ethanol, oxidative stress, and cellular oxidant detoxification. Additionally, terms related to energy-dependent detox processes (proton motive force-driven ATP synthesis and proton transmembrane transport) and the beta-ketoadipate pathway support metabolism of aromatic xenobiotics, with copper homeostasis also aligning with metal detox. Taken together, the proteins appear to function in xenobiotic detoxification and oxidative stress responses.","confidence":"High","size":14,"edges":84,"triangles":284,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042777","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0045471","count":2}]},{"hash":"1942383272583770135","title":"Transmembrane Transporters of Ions, Nutrients, and Xenobiotics","description":"The GO terms are dominated by transmembrane transport activities (ions, xenobiotics, vitamins, sugars) and related transporter functions, with a vesicular neurotransmitter loading term, suggesting a cluster of membrane transporter proteins handling diverse cargos.","confidence":"High","size":14,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":11},{"id":"GO:0006855","count":10},{"id":"GO:0035461","count":10},{"id":"GO:0042908","count":9},{"id":"GO:0042149","count":6}]},{"hash":"706191587142048989","title":"Adaptive immune signaling and angiogenesis","description":"The cluster\u2019s top GO terms center on adaptive immune processes (adaptive immune response, thymus development, Fc receptor signaling) alongside vascular development and endothelial dynamics (angiogenesis, endothelial cell migration), plus signaling pathway regulation (ERK cascade, Rho signaling). This suggests a cohesive theme of immune-vascular signaling interactions, with some residual neuronal signaling terms likely reflecting shared pathways rather than a neuronal-specific function. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031914","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0060368","count":2},{"id":"GO:0048538","count":2},{"id":"GO:0090331","count":2}]},{"hash":"1738357075696598809","title":"Mitochondrial RNA processing and transcription","description":"The cluster\u2019s top GO terms are centered on mitochondrial gene expression: transcription initiation at mitochondrial promoters, regulation of mitochondrial transcription, rRNA methylation, tRNA methylation, and maturation of SSU rRNA from tricistronic transcripts. This pattern points to coordinated mitochondrial RNA processing and transcription as the core function, with ancillary links to metabolism (ergosterol/heme biosynthesis) and general stress responses. ","confidence":"High","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006696","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0006783","count":2},{"id":"GO:1903108","count":1},{"id":"GO:0000462","count":1}]},{"hash":"236363471474677445","title":"Developmental signaling and actin remodeling","description":"The cluster\u2019s top GO terms point to broad developmental processes (telencephalon development, multicellular organism development, myoblast fusion) coupled with signaling pathways (erythropoietin signaling, regulation of JNK activity) and strong emphasis on actin cytoskeleton dynamics (actin filament binding, actin cytoskeleton reorganization, cell shape/polarity). This suggests a cohesive theme where signaling interfaces with actin-driven morphogenesis and polarity during development, spanning neural and muscle contexts, with translation regulation as a supporting layer. Confidence: Medium","confidence":"","size":14,"edges":16,"triangles":2,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":14},{"id":"GO:0007520","count":14},{"id":"GO:0021537","count":14},{"id":"GO:0045727","count":14},{"id":"GO:0031532","count":14}]},{"hash":"976971592926434356","title":"Unknown","description":"The GO terms span several unrelated biological areas: immune signaling (IgE isotype switching, type 2 immune response, pro-T cell differentiation, mast cell cytokine regulation), protein turnover (ubiquitin-dependent proteolysis) and diverse developmental/structural processes (sarcomere organization, distal tubule morphogenesis, gravitropism, synaptic vesicle endocytosis). Because there isn\u2019t a single cohesive theme linking these terms, a concise, representative label cannot be determined.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":8},{"id":"GO:0042787","count":7},{"id":"GO:0048294","count":5},{"id":"GO:2000176","count":5},{"id":"GO:0042092","count":5}]},{"hash":"2095705683460526450","title":"Immune differentiation and tissue development regulation","description":"This cluster contains GO terms spanning immune cell differentiation (positive regulation of pro-T cell differentiation; regulation of memory T cell differentiation; type 2 immune response; negative regulation of IgE isotype switching; regulation of mast cell cytokine production) and tissue development (skeletal muscle fiber development; sarcomere organization; distal tubule morphogenesis). The\u6df7emple of a regulator across immune and developmental processes suggests a common theme of broad regulatory control rather than a single tissue-specific function. The presence of synaptic vesicle endocytosis regulation and gravitropism hints at diverse regulatory roles or cross-species annotations, but the prevailing signal is regulation of differentiation and morphogenesis across multiple tissues.","confidence":"Medium","size":14,"edges":23,"triangles":10,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":6},{"id":"GO:0048741","count":6},{"id":"GO:0048294","count":5},{"id":"GO:2000176","count":5},{"id":"GO:0042092","count":5}]},{"hash":"424801901290029036","title":"Neuropeptide GPCR signaling and blood pressure control","description":"The top GO terms cluster around adenylate cyclase-activating GPCR signaling and neuropeptide pathways, including vasopressin-mediated regulation of arterial blood pressure, eating behavior, and broader neuropeptide signaling. This points to a cohesive role in neural-endocrine control of cardiovascular and metabolic homeostasis, with other terms like photoreceptor maintenance and temperature response reflecting broader physiological responsiveness but not negating the central theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0035025","count":13},{"id":"GO:0007218","count":13}]},{"hash":"460786469061831614","title":"Unknown","description":"The terms span mechanical-stimulus and cardiac electrophysiology processes (cellular response to mechanical stimulus, response to muscle stretch, SA node communication and regulation of action potential) but also include diverse differentiation signals (oligodendrocyte, follicular dendritic cell) and immune/apoptotic terms, with no clear shared function tying all 14 proteins together. ","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0048709","count":3},{"id":"GO:0072660","count":3},{"id":"GO:0002268","count":3},{"id":"GO:0035994","count":3}]},{"hash":"1545660068621183359","title":"Neuroendocrine-immune-vascular signaling","description":"The top GO terms include neuroendocrine-related regulation (vasopressin, cAMP/PKA, opioid receptor signaling), immune-related processes (IL-1\u03b2 production, dendritic cell differentiation), and vascular/hematologic functions (blood coagulation, blood pressure regulation), plus sensory-related maintenance and temperature response. This pattern suggests a cluster of proteins involved in cross-system signaling between nervous, immune, and vascular systems rather than a single, isolated pathway.","confidence":"Medium","size":14,"edges":18,"triangles":7,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":14},{"id":"GO:0001992","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0032651","count":14},{"id":"GO:0097029","count":14}]},{"hash":"832400551501953670","title":"Transmembrane Transporters","description":"This cluster is enriched for GO terms describing transport across membranes for diverse substrates: ions (potassium, sodium), nitrite/nitrate, xenobiotics, sialic acid, and even vesicular neurotransmitter loading. The shared function is transmembrane transport by transporter proteins, suggesting a cohesive group of membrane transporters with broad or substrate-specific roles.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0015707","count":4},{"id":"GO:0006855","count":4},{"id":"GO:1900754","count":4},{"id":"GO:0015706","count":4}]},{"hash":"1327014805083561103","title":"Mitochondrial Transport and Energy Metabolism","description":"The terms cluster around transport across mitochondrial membranes (citrate, ATP, ornithine, thiosulfate), regulation of membrane potential, and related metabolic processes (heme transport, amino acid starvation response, insulin signaling, and liver regeneration), indicating a cohesive group of mitochondrial transporters and energy/metabolic regulators.","confidence":"High","size":14,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":14},{"id":"GO:0015886","count":14},{"id":"GO:0032869","count":14},{"id":"GO:0000066","count":14},{"id":"GO:0097421","count":14}]},{"hash":"1119337637635005575","title":"RNA Pol II Transcription & Chromatin Modification","description":"Dominant GO terms center on RNA polymerase II\u2013mediated transcription and chromatin regulation, including transcription initiation (preinitiation complex assembly) and post-translational histone modifications (acetylation and deubiquitination). This suggests the cluster represents a nuclear transcription/epigenetic module. A few terms related to development or growth appear as noise and are less coherent with the main theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0006366","count":1},{"id":"GO:0001403","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0051123","count":1}]},{"hash":"947600180006912345","title":"Unknown","description":"The GO terms are highly heterogeneous (ubiquitination, vitamin D response, pain sensing, synaptic regulation, spindle assembly, NF-kappaB regulation, telomere maintenance, brown fat differentiation, CDK activity, and heart morphogenesis) with no clear shared function or pathway linking the proteins, so there is no coherent theme to name the cluster.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":6},{"id":"GO:0033280","count":6},{"id":"GO:0050968","count":5},{"id":"GO:1900383","count":5},{"id":"GO:0051225","count":5}]},{"hash":"1127466412151093175","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007568","count":5},{"id":"GO:0006469","count":5},{"id":"GO:0071260","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0061158","count":4}]},{"hash":"1146530934369223331","title":"NF-kB\u2013driven immune signaling and apoptosis control","description":"The top GO terms cluster around immune regulatory pathways (NF-kappaB signaling, type I interferon signaling) and modulation of T cell activation and extrinsic apoptosis, including negative regulation of necroptosis. Endosome-to-lysosome transport hints at receptor trafficking influencing signaling flux, aligning with immune signaling mechanisms. Some tissue development terms (spleen, endoderm differentiation) may reflect broader roles or annotation breadth, but the dominant signal points to immune signaling and apoptosis regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010467","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0008333","count":3},{"id":"GO:0035987","count":2},{"id":"GO:0060546","count":2}]},{"hash":"1266760331236939502","title":"Embryonic Kidney and Innate Immune Signaling","description":"The top GO terms show strong signals for kidney and related organ development (mesonephric duct development, metanephric proximal tubule development, metanephric ascending limb development, lymph vessel morphogenesis) alongside robust innate immune processes (complement activation via lectin pathway, leukocyte tethering/rolling, basophil activation, phagocytosis, response to fungal origin). This suggests a cluster of proteins involved in early kidney/vasculature development with concurrent innate immune signaling components, possibly reflecting developmental\u2013immune cross-talk or shared extracellular milieu functions.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":13},{"id":"GO:0072177","count":12},{"id":"GO:0006910","count":12},{"id":"GO:0072218","count":12},{"id":"GO:0050901","count":12}]},{"hash":"1451034335777627068","title":"Kidney tubule development and morphogenesis","description":"The strongest signals are metanephric proximal/distal tubule development and morphogenesis, plus related renal development terms such as mesonephric duct development and tubule-specific morphogenesis. Additional terms point to broader organogenesis and extracellular matrix interactions (cell-matrix adhesion, cartilage condensation, lymph vessel morphogenesis). A couple of immune-related terms may be incidental. Overall, the cluster centers on renal tubule development with ancillary morphogenetic processes.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0001867","count":10},{"id":"GO:0071226","count":9},{"id":"GO:0072287","count":8},{"id":"GO:0072237","count":8},{"id":"GO:0036303","count":8}]},{"hash":"1887640319502336319","title":"Wnt Signaling and Protein Turnover","description":"The proteins appear to co-function in regulation of signaling pathways, especially Wnt (canonical and planar cell polarity) and NF-kappaB, while also modulating protein abundance through ubiquitin-related processes (deubiquitination and ubiquitin-independent proteasomal degradation). There are links to cell-cycle control (G2/M) and mRNA stability, with some auxiliary signals about stress responses and viral processes. This suggests a cohesive theme of signaling modulation coupled with protein turnover rather than a single enzymatic activity.","confidence":"Medium","size":13,"edges":61,"triangles":145,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0010950","count":4},{"id":"GO:0010972","count":4},{"id":"GO:0060071","count":3},{"id":"GO:0043488","count":3},{"id":"GO:0038061","count":3}]},{"hash":"593850616205681640","title":"Anthocyanin and flavonoid biosynthesis","description":"This cluster is dominated by GO terms for biosynthesis of anthocyanin and other flavonoids (kaempferol/quercetin/cyanidin glucosides), as well as related lignin biosynthesis, pointing to a shared theme of phenylpropanoid-derived metabolite production. Some terms appear as potential noise (e.g., axon localization), but the core function aligns with flavonoid pigment and related metabolite synthesis.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":6,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0033330","count":6},{"id":"GO:0033303","count":6},{"id":"GO:0009808","count":6}]},{"hash":"240848784172627488","title":"Developmental transcriptional control","description":"The cluster centers on developmental processes (mammary gland alveolus development; Leydig cell differentiation) and transcription regulation (DNA-templated transcription; negative regulation of transcription by RNA polymerase II), with some links to cell cycle and ER stress responses, suggesting a group of genes involved in controlling gene expression during development.","confidence":"Medium","size":13,"edges":14,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060749","count":6},{"id":"GO:0033327","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0000122","count":6},{"id":"GO:1990069","count":5}]},{"hash":"474448119500131186","title":"Axon Guidance and Neural Crest Migration","description":"The terms cluster around axon extension and guidance (semaphorin-plexin signaling, sympathetic/trigeminal neuron projection guidance, branchiomotor neuron axon guidance) and neural crest cell migration, with ECM context from collagen fibril organization. Inflammatory/chemokine terms appear ancillary, but the dominant theme is neural development and axon pathfinding.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048846","count":6},{"id":"GO:0030199","count":5},{"id":"GO:1902287","count":5},{"id":"GO:0097490","count":5},{"id":"GO:0021637","count":5}]},{"hash":"181406607426307281","title":"Neural development and cell signaling cluster","description":"Proteins in this cluster are enriched for neural development processes (axon regeneration, cerebellar cortex formation, inner ear development) and signaling pathways (integrin-mediated signaling, PDGF response, insulin signaling), with additional differentiation cues (keratinocyte differentiation). This suggests a common theme of coordinating development with signaling and adhesion mechanisms. ","confidence":"Medium","size":13,"edges":59,"triangles":160,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000811","count":10},{"id":"GO:0048679","count":10},{"id":"GO:0030216","count":10},{"id":"GO:0008286","count":10},{"id":"GO:0048839","count":10}]},{"hash":"491790768034020758","title":"Organogenesis and Branching Morphogenesis","description":"This cluster centers on developmental processes and tissue morphogenesis, with terms like angiogenesis, multicellular organism development, and branching morphogenesis of salivary glands and lung mesenchyme, all tied to signaling pathways such as ERK/MAPK. The sarcomere organization term may reflect muscle development within organogenesis. Overall, the common theme is organ development guided by signaling during branching and tissue patterning.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0060665","count":2}]},{"hash":"670529764723979101","title":"Brain development and mitochondrial calcium signaling","description":"The cluster includes neural development terms (substantia nigra development; in utero embryonic development) and mitochondrial calcium handling (calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration), plus corticosterone response indicating brain-related hormonal signaling. Translation and cytolysis are broader cellular processes, but the dominant theme centers on neural development coupled with mitochondrial calcium signaling.","confidence":"Medium","size":13,"edges":75,"triangles":254,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0036444","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0051412","count":2},{"id":"GO:0051561","count":2}]},{"hash":"788710609853306801","title":"Clathrin-mediated endocytosis and endosome organization","description":"This cluster centers on membrane trafficking, with core terms for clathrin-dependent endocytosis and GPCR internalization, plus endosome organization, suggesting a cohesive role in receptor/cargo internalization and trafficking. Lamellipodium assembly hints at linked cytoskeletal remodeling, while lipid metabolism terms appear less directly connected.","confidence":"Medium","size":13,"edges":74,"triangles":248,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030259","count":2},{"id":"GO:0072583","count":2},{"id":"GO:0016126","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0002031","count":2}]},{"hash":"291133180497876417","title":"Developmental signaling and cytoskeleton regulation","description":"The GO terms indicate a mix of developmental signaling (heart development, apoptotic processes), calcium signaling and neuronal plasticity (calcium transport, long-term potentiation), and cytoskeletal/polarity regulation (Rho signaling, GTPase activity, cell polarity, lipid tube assembly). Together they reflect interconnected signaling pathways that govern development and structural organization across tissues, supporting a cohesive, high-level label despite tissue diversity.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0070588","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0006470","count":2}]},{"hash":"1735518205311559913","title":"Telomere regulation and PARP activity","description":"This cluster centers on telomere biology: terms describe telomere maintenance, capping, and localization to telomeres, including regulation by telomerase. PARP-related terms (poly- and auto-ADP-ribosylation) indicate involvement of PARP enzymes in telomere/chromatin regulation. A couple of terms about spindle assembly or endothelial tube extension appear ancillary. Overall, the dominant theme is telomere maintenance and PARP activity.","confidence":"High","size":13,"edges":11,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0070212","count":2},{"id":"GO:0070198","count":2},{"id":"GO:1904355","count":2}]},{"hash":"1155154845971760317","title":"Unknown","description":"The top terms span widely different processes (cell cycle regulation, host\u2013symbiont interaction, synaptic vesicle clustering, bone mineralization, endosome transport, insulin-responsive glucose uptake, interferon responses, neuromuscular posture, and general biotic stimuli) with little overlap or connectivity among proteins (max degree 1, no triangles). This suggests there isn\u2019t a single coherent biological function unifying the cluster, so a generic Unknown label is most appropriate.","confidence":"","size":13,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1900087","count":2},{"id":"GO:0046597","count":1},{"id":"GO:0097091","count":1},{"id":"GO:0030282","count":1},{"id":"GO:0099638","count":1}]},{"hash":"42074927413466476","title":"Inflammatory signaling and hematopoietic regulation","description":"The GO terms cluster around inflammatory mediator production (prostaglandin biosynthesis), immune/hematopoietic processes (myeloid progenitor proliferation), and broad signaling pathway regulation (NF-kappaB, ERK, glucocorticoid and insulin signaling), plus effects on fibroblast proliferation. Together, they point to signaling networks that govern inflammation and hematopoietic/mesenchymal cell behavior.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":12},{"id":"GO:0032869","count":8},{"id":"GO:0035726","count":8},{"id":"GO:0032930","count":8},{"id":"GO:0043124","count":8}]},{"hash":"1498954086377938059","title":"Nuclear RNA processing and mitotic functions","description":"The top GO terms cluster around nuclear gene expression and RNA processing (negative regulation of transcription by RNA Pol II, nuclear mRNA surveillance, ITS1 rRNA processing, NLS-dependent nuclear import, Pol II tethering at the nuclear periphery) and mitotic chromosome organization (protein localization to kinetochore, mitotic metaphase chromosome alignment), with some related RNA turnover/transport roles (tRNA transport, proteasome assembly). This suggests a cohesive theme of nuclear regulation of transcription/RNA processing coupled with chromosome segregation during cell division.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0071033","count":2},{"id":"GO:0043248","count":2},{"id":"GO:0000973","count":2},{"id":"GO:0000447","count":2}]},{"hash":"1675069350735822338","title":"DNA Replication and Repair","description":"The top GO terms cluster around DNA replication and genome maintenance: replication fork processing, DNA amplification, and double-strand break repair via SSA, plus UV protection and DNA damage response signals. While a term about mitochondrial energy suggests some functional diversity, the dominant theme is genome replication/repair.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046944","count":1},{"id":"GO:0042775","count":1},{"id":"GO:0061179","count":1},{"id":"GO:0009650","count":1},{"id":"GO:0006277","count":1}]},{"hash":"1126300334112607174","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":21,"triangles":9,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0072011","count":5},{"id":"GO:2000177","count":5},{"id":"GO:0061146","count":5},{"id":"GO:0031064","count":5},{"id":"GO:0032914","count":5}]},{"hash":"2075100451503626047","title":"Inositol/Phosphatidylinositol biosynthesis and ABA stress response","description":"The cluster is dominated by GO terms for inositol and phosphatidylinositol biosynthesis (inositol biosynthetic process, phosphatidylinositol biosynthetic process, phosphatidylinositol phosphate biosynthetic process) alongside ABA-activated signaling and hyperosmotic salinity response, indicating a coherent theme of lipid signaling pathways that mediate osmotic/ABA-driven stress responses. Some unrelated terms (e.g., certain developmental/hair cell differentiation annotations) may be incidental, but do not override the core signaling/metabolic pattern.","confidence":"High","size":13,"edges":11,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":5},{"id":"GO:0006661","count":4},{"id":"GO:0042538","count":4},{"id":"GO:0046855","count":4},{"id":"GO:0006094","count":4}]},{"hash":"1986757496426776270","title":"Morphogenesis and Cytoskeletal Dynamics","description":"The cluster centers on developmental morphogenesis across species (haltere in insects, plant ovules, metanephric kidney structures) and is tied to cytoskeletal remodeling, with lamellipodium assembly and actin filament depolymerization highlighting actin dynamics, plus integrin signaling and other pathways that regulate cell adhesion and movement during tissue shaping. While some terms touch on transcription and cell wall biosynthesis, the common thread appears to be processes that sculpt tissues via cytoskeletal reorganization and signaling. This suggests a cohesive theme around how cells rearrange and interact during development.","confidence":"Medium","size":13,"edges":67,"triangles":190,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":6},{"id":"GO:0048735","count":6},{"id":"GO:0042789","count":6},{"id":"GO:0090334","count":6},{"id":"GO:0008588","count":6}]},{"hash":"1085044120886220171","title":"Embryonic neural and craniofacial development","description":"This cluster is dominated by GO terms for in utero embryonic development, cerebral cortex development, neuron maturation, cartilage morphogenesis, and roof of mouth development, pointing to coordinated neural and craniofacial organogenesis. Additional terms on chromatin regulation (histone methylation, chromatin binding) suggest epigenetic control during this developmental program. A few xenobiotic response terms are present but less central. Overall, the cluster appears to represent epigenetically regulated embryonic neural and craniofacial development.","confidence":"High","size":13,"edges":43,"triangles":55,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0021983","count":4},{"id":"GO:0051573","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0042551","count":4}]},{"hash":"1164600684528940925","title":"Membrane Solute Transporters","description":"The top GO terms are dominated by transmembrane transport activities across a variety of substrates (nitrite, nitrate, xenobiotics, vitamins, sodium ions, sialic acid) and even neurotransmitter loading into vesicles, indicating a cohesive function as membrane transporters for diverse solutes.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":3},{"id":"GO:0006855","count":3},{"id":"GO:1900754","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0042128","count":3}]},{"hash":"158605271045494788","title":"Neuronal development and axon guidance","description":"This cluster is dominated by GO terms related to neural development, axon guidance, synapse assembly, neuron differentiation, and cell adhesion (including semaphorin-plexin signaling). While there are a couple bone-related terms (ossification, BMP signaling), the prevailing theme ties to neuronal wiring and synaptic maturation, suggesting a cohesive neural development module.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":11},{"id":"GO:0043931","count":11},{"id":"GO:0030513","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0051965","count":10}]},{"hash":"543139597635277257","title":"Redox signaling and GTPase regulation","description":"Top GO terms point to redox biology (hydrogen peroxide biosynthesis, superoxide generation) and signaling control (peptidyl-tyrosine dephosphorylation; regulation of GTPase activity). Some terms relate to muscle/platelet contexts (muscle cell homeostasis, platelet degranulation), suggesting roles in context-specific signaling; an outlier membrane-related term may reflect broader membrane dynamics rather than a core function. Overall, the cluster seems centered on redox-modulated signaling via GTPases.","confidence":"Medium","size":13,"edges":47,"triangles":79,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035335","count":5},{"id":"GO:0043087","count":5},{"id":"GO:0046716","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0050665","count":4}]},{"hash":"1759471114473096834","title":"Brain development and neural signaling with immune cues","description":"Terms show brain development (forebrain, brain development) and neural processes (neurotransmitter secretion), plus immune-related terms (inflammatory response, T cell receptor signaling) and stress responses (hypoxia, mechanical stimulus). The cluster appears to capture neural development processes with ancillary immune and stress signaling, so the label focuses on neural development with immune context.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0006954","count":3}]},{"hash":"1013728035824798076","title":"Antiviral and LPS-induced innate immune signaling","description":"The top GO terms point to innate immune activation in response to viral components (defense response to virus, dsRNA response) and bacterial components (lipopolysaccharide signaling, TLR4 signaling, LPS response), with chemokine production and immunoglobulin-mediated responses indicating downstream inflammatory signaling. This combination strongly suggests a coordinated role in sensing pathogens and triggering chemokine production, characteristic of innate antiviral and LPS-driven immunity.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071651","count":3},{"id":"GO:2000340","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0031663","count":3}]},{"hash":"1445739434924771517","title":"Growth-factor signaling and development","description":"This cluster centers on growth-factor\u2013driven signaling (insulin receptor, GH receptor, erythropoietin pathways) and developmental processes (myoblast fusion, telencephalon development, broader multicellular development), with translational regulation and kinase activity modulation enriching the theme. The proteins likely participate in vertebrate muscle and neural development under growth signaling control.","confidence":"Medium","size":13,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046626","count":4},{"id":"GO:0060396","count":4},{"id":"GO:0038162","count":2},{"id":"GO:0007520","count":2},{"id":"GO:0021537","count":2}]},{"hash":"190543364016267516","title":"Ubiquitin-regulated skeletal muscle development","description":"The cluster is dominated by skeletal muscle biology terms (sarcomere organization; skeletal muscle cell differentiation; skeletal muscle tissue development) together with multiple ubiquitination-related terms (ubiquitin-dependent protein catabolic process; K33-linked ubiquitination; negative regulation of ubiquitination), suggesting muscle development processes governed by ubiquitin signaling. Kidney and nervous system terms are present but less central. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0045214","count":9},{"id":"GO:0072156","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0035914","count":9}]},{"hash":"256421478317968267","title":"Immune T-cell regulation and histone modification","description":"Top terms indicate immune regulation (negative regulation of T-helper cell differentiation, T cell homeostasis, vitamin D response, negative regulation of viral transcription) alongside chromatin-associated processes (histone catabolic process; histone acetylation), with ancillary ubiquitination and peptide amidation signals; this points to an immune-epigenetic regulatory cluster.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033280","count":11},{"id":"GO:0030433","count":11},{"id":"GO:0045623","count":10},{"id":"GO:0036205","count":10},{"id":"GO:0043029","count":10}]},{"hash":"1913707505123579166","title":"Glycinergic signaling and amino acid transport","description":"This cluster centers on glycine-related neural function, with terms for glycinergic synaptic transmission, glycine import, and myelination, suggesting a theme of neural signaling and amino acid handling. Transport terms for other amino acids (proline, leucine) support a broader link to amino acid movement, while outliers like Fc-epsilon signaling and heart development are less central to the main neural theme. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0045163","count":2},{"id":"GO:0042552","count":2}]},{"hash":"744543009274993540","title":"Developmental and reproductive signaling regulators","description":"This cluster centers on GO terms describing developmental processes (palate development, left-right pattern formation, ovarian follicle development) and hormonal/reproductive signaling (cellular response to GnRH, receptor clustering, Rho signaling regulation). It also includes regulatory aspects of angiogenesis and macrophage activation, suggesting broader signaling control during development and reproductive biology. The common theme is regulatory signaling in development and the reproductive axis, though the terms span multiple related systems.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:2001223","count":2},{"id":"GO:0043129","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0035025","count":2}]},{"hash":"36698044094070314","title":"Embryonic patterning and organogenesis","description":"The top GO terms cluster around embryonic development and tissue patterning (left/right pattern formation; pancreatic endocrine development; endocrine system development; EMT in endocardial cushion formation; trophoblast giant cell differentiation; placenta development; cartilage morphogenesis). Some outliers in metabolic processes (isoquinoline alkaloid metabolism, oxylipin biosynthesis) do not alter the overall developmental theme. Thus, the proteins likely participate in embryogenesis and organ formation processes.","confidence":"High","size":13,"edges":16,"triangles":5,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":9},{"id":"GO:0003323","count":9},{"id":"GO:0035270","count":9},{"id":"GO:0003198","count":9},{"id":"GO:0060707","count":9}]},{"hash":"1301443833030398595","title":"Complement activation and embryonic development","description":"Top terms include complement activation pathways and blood coagulation, plus several embryonic development processes (left/right patterning, placental and endocrine development, EMT in endocardial cushion formation). This suggests the proteins span both immune/coagulation functions and developmental pathways, hence the label.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0006958","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0030574","count":4},{"id":"GO:0060972","count":4}]},{"hash":"141737276900718121","title":"Neural development and synapse formation","description":"This cluster is chiefly tied to neural connectivity, with GO terms like corpus callosum development, positive regulation of synapse assembly, and axonal fasciculation indicating roles in synapse formation and axon pathfinding. While there are a couple of non-neural terms (defense response and sugar catabolic processes) represented, they appear peripheral to the dominant neural development signal. Confidence reflects this moderate alignment being the core theme, hence Medium.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0048681","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1614631400430890964","title":"Vascular-immune Regulation","description":"The top GO terms are dominated by vascular processes (positive regulation of vasoconstriction, angiogenesis, and positive regulation of angiogenesis) alongside immune signaling (adaptive immune response, cytokine production), suggesting a cluster centered on immunovascular regulation. Some development and cell-cycle terms appear as secondary annotations, but they don\u2019t redefine the primary theme. Confidence in this label is Medium.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045907","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0043137","count":1}]},{"hash":"422751452388093096","title":"Developmental signaling regulation","description":"This cluster centers on development-related terms, including spinal cord development and skeletal muscle cell differentiation, alongside negative regulation of BMP and TGF-\u03b2 signaling pathways\u2014pointing to inhibitory control of key developmental cues. While a couple of RNA processing and cytoskeletal terms are present, the dominant pattern is regulation of developmental signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0006401","count":1},{"id":"GO:0071765","count":1}]},{"hash":"1666894332529024058","title":"Neural development and Wnt signaling","description":"The cluster is dominated by GO terms related to Wnt/calcium signaling and neural development (retina layer formation, substantia nigra development), suggesting a shared role in brain development and signaling. While other terms touch on bone formation, cell cycle, and xenobiotic response, the neural development and Wnt signaling theme best captures the central pattern, giving a medium confidence.","confidence":"Medium","size":12,"edges":7,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007223","count":5},{"id":"GO:0051281","count":5},{"id":"GO:0006469","count":5},{"id":"GO:0010842","count":4},{"id":"GO:1900242","count":4}]},{"hash":"2180723233602129209","title":"Flowering time and inflorescence development","description":"The cluster\u2019s GO terms center on plant reproductive development, including regulation of the vegetative-to-reproductive transition, flower development, inflorescence development, and photoperiodic flowering (short-day flowering). This points to a coherent theme around when and how flowers form and structures like inflorescences, with supporting terms such as cell differentiation. A single term about stimulatory C-type lectin receptor signaling appears unrelated and likely noise, but does not detract from the overall flowering-focused function of the cluster.","confidence":"High","size":12,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":2},{"id":"GO:0048510","count":2},{"id":"GO:0009908","count":2},{"id":"GO:0009910","count":2},{"id":"GO:0048575","count":2}]},{"hash":"898272830398443167","title":"Wnt-Driven Development and Organogenesis","description":"Most terms point to developmental processes and organ formation (heart development, angiogenesis, multicellular development), with Wnt signaling and calcium modulation as core pathways. While a few terms (e.g., Fc-epsilon receptor signaling) are less central, the overall pattern supports signaling-driven development and organogenesis rather than a single, narrow function.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":2,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007223","count":6},{"id":"GO:0072205","count":6},{"id":"GO:0051281","count":6},{"id":"GO:0048168","count":6},{"id":"GO:0042994","count":6}]},{"hash":"1497288456579676891","title":"Tissue Development and Organogenesis","description":"The top GO terms point to developmental and morphogenetic processes across multiple tissues and organs\u2014glomerular basement membrane development and filtration (kidney), CNS development, esophagus smooth muscle contraction, colon epithelial migration, and prostatic bud formation regulation\u2014along with related signaling (e.g., glial-derived neurotrophic factor receptor signaling, innervation) and a general immune response component. This pattern suggests a cluster of proteins involved in broad tissue development and organogenesis rather than a single, isolated pathway. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032836","count":7},{"id":"GO:0031953","count":6},{"id":"GO:0006955","count":6},{"id":"GO:0003094","count":6},{"id":"GO:0014846","count":6}]},{"hash":"169510367690181675","title":"Embryonic brain and craniofacial development","description":"The cluster's top GO terms center on brain development, embryonic cranial skeleton morphogenesis, and trigeminal ganglion development, pointing to a shared role in early neural and craniofacial formation. A transcriptional repression term (negative regulation of transcription by RNA polymerase II) suggests coordinated gene regulation during this developmental program, while terms like single fertilization and male gonad development may reflect broader embryogenesis rather than brain-specific functions.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0048701","count":3},{"id":"GO:0061551","count":3},{"id":"GO:0008584","count":3}]},{"hash":"1276732322663038459","title":"Cofactor and Metabolite Biosynthesis","description":"The cluster shows strong representation of biosynthetic processes (heme/protoporphyrinogen IX, biotin, kynurenic acid, L-lysine biosynthesis, oxaloacetate metabolism), pointing to a metabolic module centered on production of cofactors and key metabolites. A few terms related to insulin response, fruit ripening, and transcription appear more general or annotation-driven, but the dominant signal is biosynthesis/metabolism.","confidence":"Medium","size":12,"edges":22,"triangles":22,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032869","count":5},{"id":"GO:0006782","count":5},{"id":"GO:0009102","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0009835","count":4}]},{"hash":"1075747199370401477","title":"Neural development and neuronal differentiation","description":"This cluster is enriched for GO terms focused on neural development and neuron differentiation, including spinal cord motor neuron fate specification, cerebral cortex GABAergic interneuron differentiation, spinal cord oligodendrocyte fate specification, and subpallium neuron fate commitment, indicating a shared theme of nervous system development. Transcription by RNA polymerase II suggests active gene expression underlying these developmental programs. While there are terms for other organ systems (bronchiole, retina, endocrine pancreas, osteoblast development), the predominant signal is neural fate specification and differentiation.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0021520","count":9},{"id":"GO:0021892","count":9},{"id":"GO:0021530","count":9},{"id":"GO:0060435","count":9}]},{"hash":"1376316592497204768","title":"Spliceosome regulation and miRNA processing","description":"The terms point to RNA post-transcriptional processing, especially miRNA processing and regulation of mRNA splicing via the spliceosome (including alternative splicing). There are also hints of broader RNA maturation steps and a potential link to spermatid development, but the dominant signal is RNA processing. ","confidence":"Medium","size":12,"edges":56,"triangles":134,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035196","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0048024","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0007175","count":1}]},{"hash":"2206036326894900412","title":"Actin Cytoskeleton Remodeling and Chromatin Regulation","description":"This cluster blends cytoskeletal signals (Arp2/3 actin nucleation; sarcomere organization; regulation of endocytosis) with chromatin-related processes (histone acetylation; heterochromatin formation; chromosome movement), implying a theme of coordinated cytoskeletal and chromatin dynamics in development and meiosis.","confidence":"Medium","size":12,"edges":55,"triangles":128,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0016344","count":4},{"id":"GO:0009825","count":4},{"id":"GO:0043983","count":4},{"id":"GO:0034314","count":4},{"id":"GO:0042766","count":4}]},{"hash":"1703561652312470892","title":"Cardiovascular inflammation and angiogenesis","description":"The cluster\u2019s terms cluster around vascular and immune processes: blood coagulation, inflammatory response, vasoconstriction regulation, sprouting angiogenesis, and endocardial cell differentiation, with a supporting signal from lipopolysaccharide response. While there are a few terms tied to nervous system development and behavior, the dominant themes point to inflammatory\u2013vascular signaling and cardiovascular development, justifying a label focused on cardiovascular inflammation and angiogenesis.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0048484","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0045907","count":2},{"id":"GO:0019233","count":2}]},{"hash":"871066000462104236","title":"Innate immune signaling and NF-kB regulation","description":"This cluster is driven by GO terms linking Toll-like receptor/MyD88 signaling, NF-kappaB pathway activation and regulation, and responses to lipopolysaccharide, plus modulation of T and B cell proliferation and extrinsic apoptotic signaling. Together they point to immune signaling and inflammation control as the core function of these proteins.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050728","count":4},{"id":"GO:0043029","count":3},{"id":"GO:2000002","count":3},{"id":"GO:2001241","count":3},{"id":"GO:0030889","count":3}]},{"hash":"1159829699070725779","title":"Mitotic Chromatid Cohesion and DNA Replication","description":"The cluster is dominated by GO terms related to mitosis and chromosome management, including sister chromatid cohesion and segregation, mitotic DNA replication, and replication fork progression, indicating a theme around chromosome handling during cell division. A couple of terms about mRNA processing and translation appear, which may reflect housekeeping functions or noisy annotations rather than core cluster function. Overall, the core signal points to mitotic chromosome cohesion and DNA replication.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0044376","count":1},{"id":"GO:0007064","count":1},{"id":"GO:0034087","count":1}]},{"hash":"1146607399991612628","title":"Epithelial and organ development","description":"GO terms point to developmental processes across tissues: skin development, maintenance of epithelial integrity, nephron/kidney and renal system development, sprouting angiogenesis, and related organogenesis, with DNA-templated transcription as a common regulatory mechanism. This pattern supports a label centered on tissue and organ development involving epithelia and associated systems.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0007613","count":1},{"id":"GO:0035024","count":1}]},{"hash":"1461656839401365052","title":"Immune signaling and programmed cell death","description":"The top GO terms mainly cluster around immune responses (immunoglobulin-mediated response; interleukin-12 signaling and Th1 differentiation) and programmed cell death pathways (necroptosis; extrinsic apoptotic signaling; ectopic germ cell death), with macropinocytosis as an associated immune process. This suggests a theme of immune signaling linked to cell death mechanisms, though a few terms like nutrient response and development are less cohesive with the core theme.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":1},{"id":"GO:0016064","count":1},{"id":"GO:0010800","count":1},{"id":"GO:0007275","count":1},{"id":"GO:0070266","count":1}]},{"hash":"2126758637878696846","title":"Actin Cytoskeleton Remodeling in Development and Immunity","description":"This cluster centers on actin cytoskeleton dynamics, with lamellipodium assembly and actin organization as key features, pointing to cell migration and structural remodeling. The accompanying terms suggest signaling contexts (adaptive immune response, Fc receptor signaling, synaptic transmission) and developmental processes (cerebellum morphogenesis, distal tip cell migration, parathyroid development), which can all involve cytoskeletal remodeling, supporting a unifying theme around actin-driven movement and signaling in development and immune-related contexts.","confidence":"Medium","size":12,"edges":28,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0060368","count":2},{"id":"GO:0030032","count":1},{"id":"GO:0016560","count":1}]},{"hash":"1406012991132965189","title":"RNA Splicing and DNA Damage Response","description":"The proteins show enrichment in nuclear RNA processing (mRNA splicing, nonsense-mediated decay, rRNA maturation) alongside signals of genome maintenance (DNA topology changes, SOS response, UV protection), suggesting a cluster focused on RNA processing and DNA damage response. Some terms are less directly related, but the core theme is coherent.","confidence":"Medium","size":12,"edges":13,"triangles":2,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0060303","count":1},{"id":"GO:0009650","count":1},{"id":"GO:0006265","count":1},{"id":"GO:0000184","count":1}]},{"hash":"426797204704239363","title":"Presynaptic Vesicle Clustering and Active Zone Organization","description":"The cluster is dominated by GO terms pointing to presynaptic apparatus: vesicle clustering, regulated vesicle exocytosis, neurexin clustering for presynaptic membrane assembly, and cytoskeletal organization at the active zone. These collectively indicate a role in organizing and regulating presynaptic release sites, with some unrelated terms (e.g., steroid or alkaloid responses) present but not central. ","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1902474","count":10},{"id":"GO:0097091","count":10},{"id":"GO:2000302","count":10},{"id":"GO:0051384","count":10},{"id":"GO:0043279","count":10}]},{"hash":"683154787885618217","title":"Organelle protein import and vesicle trafficking","description":"The cluster centers on protein targeting and trafficking across organelles, including mitochondrial import into the matrix and inner membrane, ER-to-Golgi transport, endosome-to-Golgi retrograde trafficking, autophagosome docking, and vacuolar membrane targeting/fusion, suggesting a cohesive role in intracellular membrane trafficking and protein delivery between organelles; a few peripheral immune-related terms do not negate the overall theme.","confidence":"Medium","size":12,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0032869","count":1},{"id":"GO:0098967","count":1},{"id":"GO:0042147","count":1}]},{"hash":"887320977373482443","title":"Embryogenesis and placental development","description":"Genes in this cluster are enriched for embryonic development processes, including trophoblast differentiation and placental formation, left-right patterning, in utero embryonic development, and broader organogenesis (endocrine system, cartilage, neurons). The recurring theme is embryogenesis with a strong focus on placental development and early axis formation; a few terms about immune response may reflect secondary roles. Confidence: High","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0060972","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"435025414173690335","title":"Methylation and RNA wobble modification","description":"The cluster shows a clear enrichment for methylation-related processes, including protein methylation and tRNA wobble uridine modification, pointing to a core theme of methylation-based RNA and protein modification. Other terms like cobalamin biosynthesis and lignin biosynthesis appear less related and may reflect broader metabolic annotations or noise, but the strongest signal is in methylation and RNA modification, supporting this label.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":6},{"id":"GO:0009809","count":5},{"id":"GO:0042135","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0042420","count":4}]},{"hash":"2074866293374408114","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The proteins in this cluster are linked by themes of actin cytoskeleton dynamics and cell movement: stress fiber assembly, actin cytoskeleton reorganization, nuclear migration, and wound healing/spreading of cells. They are also associated with signaling pathways that regulate cytoskeletal remodeling, such as positive regulation of ERK1/ERK2 cascade and serine phosphorylation, as well as ubiquitination processes and modulation of NF-kappaB signaling. The presence of mechanotransduction-related terms (sensory perception of touch) further supports a role in sensing and responding to mechanical cues. Together, these terms point to a cohesive function in cytoskeleton-driven cell migration and tissue repair.","confidence":"Medium","size":12,"edges":17,"triangles":6,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0050975","count":4},{"id":"GO:0043149","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0016567","count":4}]},{"hash":"533615604025793230","title":"Neural Development and Angiogenesis","description":"The cluster is dominated by GO terms related to neural development (peripheral nervous system development, myelination, embryonic body morphogenesis) and blood vessel formation (angiogenesis), along with adhesion and migration processes (cell-cell adhesion, substrate-dependent migration) that support neural and vascular tissue morphogenesis. While there are also terms touching immune costimulation and broader development, the core signal points to coordinated neural maturation and angiogenic remodeling.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":11},{"id":"GO:1904237","count":11},{"id":"GO:0001525","count":11},{"id":"GO:2000525","count":11},{"id":"GO:0007422","count":11}]},{"hash":"217256601783066147","title":"Neural development and myelination","description":"The top GO terms cluster around nervous system development and maturation, including myelination, corpus callosum development, peripheral nervous system development, and synapse assembly. This indicates proteins likely involved in neural connectivity and myelin formation, with related signaling and cell\u2013ECM interactions. While terms like angiogenesis and collagen organization appear, the core theme is neural development and myelination.","confidence":"High","size":12,"edges":47,"triangles":83,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":9},{"id":"GO:0030199","count":9},{"id":"GO:0022038","count":9},{"id":"GO:0051965","count":9},{"id":"GO:0007169","count":9}]},{"hash":"1547578891472678363","title":"GABAergic synaptic vesicle cycling and actin remodeling","description":"The terms point to neuronal synapses, particularly inhibitory GABAergic signaling (GABAergic synaptic transmission; regulation of synaptic vesicle exocytosis) and vesicle recycling processes, alongside actin cytoskeleton remodeling (filopodium/lamellipodium assembly). Some terms also touch on brain development and endothelial barrier establishment, but the strongest cohesive signal is synaptic vesicle trafficking coupled with actin dynamics at inhibitory synapses. Therefore this label captures the core functional theme of the cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0051932","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0032456","count":3},{"id":"GO:0021762","count":3}]},{"hash":"1155816195556888531","title":"Brain and hindbrain neural development","description":"The top GO terms cluster around embryonic neural development and brain regionalization\u2014trigeminal ganglion development, retinal ganglion cell axon guidance, midbrain development, rhombomere 4 and 5 development, brain segmentation, and retrotrapezoid nucleus neuron differentiation\u2014indicating a cohesive theme of neural patterning and brain region specification. A broader term about transcriptional regulation is present but secondary to this neural-development focus. Overall, the proteins are best described as involved in neural development and brain regionalization. ","confidence":"High","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061551","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0031290","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0007501","count":5}]},{"hash":"763316629957976348","title":"Flavonoid and lignin biosynthesis","description":"The top GO terms are dominated by various flavonoid biosynthetic processes (kaempferol, quercetin, cyanidin glycosides) and lignin metabolism, all core to phenylpropanoid-derived secondary metabolism in plants. While one axon-related term appears, the strongest signal is flavonoid/lignin biosynthesis, implying a cluster centered on phenylpropanoid production. ","confidence":"High","size":12,"edges":6,"triangles":1,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0033330","count":5},{"id":"GO:0033303","count":5},{"id":"GO:0009808","count":5},{"id":"GO:0002175","count":5}]},{"hash":"478019994715428546","title":"Extrinsic Apoptosis and Immune Regulation","description":"The top GO terms cluster mainly around regulation of the extrinsic apoptotic signaling pathway, including both positive and negative regulation, plus related immune processes such as activation-induced T cell death and immunoglobulin production, with STAT signaling involvement. Some terms touch neural and cardiac development, but the dominant theme is apoptosis signaling and immune function.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":2},{"id":"GO:0021859","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0086014","count":2},{"id":"GO:1902042","count":2}]},{"hash":"889696410378558756","title":"Embryonic vascular and ECM remodeling","description":"This cluster shows strong signals for embryonic development (in utero embryonic development, somite development) and vascular-related processes (positive regulation of angiogenesis) as well as extracellular matrix organization (collagen fibril organization). These points together suggest a theme of developmental progression involving blood vessel formation and ECM remodeling during embryogenesis. Immune-related terms (complement activation and MAC) are present but appear secondary to the core developmental/ECM-vascular theme; some metabolic terms (cholesterol biosynthesis regulation) may reflect broader cellular regulation in development. ","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045541","count":2},{"id":"GO:0006957","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0061053","count":2},{"id":"GO:0006958","count":2}]},{"hash":"835660874968364010","title":"Unknown","description":"The top GO terms are highly diverse, spanning eye and heart development, neuronal migration, visual perception, behavior, germ cell differentiation, EGFR ligand maturation, immune regulation, and stress responses. There is no single cohesive function or process tying all terms together, so a specific high-level label would be misleading; thus Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0021853","count":2},{"id":"GO:0043278","count":2},{"id":"GO:0007601","count":2}]},{"hash":"1636891908878001397","title":"CNS axon guidance and synapse formation","description":"The cluster is dominated by GO terms related to neural connectivity and synapse organization\u2014axon extension, fasciculation, corpus callosum development, and synapse assembly, along with regulation of synaptic plasticity and ephrin signaling. A few innate immune TLR signaling terms appear but do not define the core theme, which is axon guidance and synapse formation in the CNS.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":2},{"id":"GO:0022038","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0051965","count":2},{"id":"GO:1901187","count":2}]},{"hash":"96329257387644813","title":"Plant hormone metabolism and fruit ripening","description":"Top terms cluster around gibberellin and auxin turnover (biosynthesis and catabolism), salicylic acid catabolism, and plant developmental processes such as fruit ripening, together with secondary metabolism (proanthocyanidin biosynthesis) and stress-related responses (hydrogen peroxide\u2013mediated programmed cell death). This constellation suggests a cohesive theme of plant hormone regulation coupled with fruit development and related metabolic pathways, rather than a general, non-specific set of processes.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:1902835","count":2},{"id":"GO:0010023","count":2},{"id":"GO:0042318","count":2},{"id":"GO:0010421","count":2}]},{"hash":"1222156162261590106","title":"Neuronal adhesion and ganglioside metabolism","description":"Among the top GO terms, neuron cell-cell adhesion and ganglioside catabolic process stand out as the most representative across the cluster, pointing to neuronal connectivity and lipid metabolism. While there are additional terms related to extracellular matrix organization and apoptotic cell recognition, the strongest common theme centers on neuronal adhesion and ganglioside turnover, supporting a label that highlights neuronal interactions with lipid catabolism.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006689","count":4},{"id":"GO:0051692","count":4},{"id":"GO:0043654","count":3},{"id":"GO:0007158","count":3},{"id":"GO:0030199","count":3}]},{"hash":"945613755896923685","title":"Lipid and vitamin biosynthesis","description":"This cluster\u2019s top GO terms are dominated by biosynthetic processes of lipids and vitamins: fatty acid elongation, very long-chain fatty acid biosynthesis, sphingolipid biosynthesis, retinoic acid biosynthetic process, and phylloquinone-related metabolism, alongside general transcription regulation and other processes. The strongest signal points to lipid metabolism and vitamin biosynthesis pathways, with more divergent terms representing broader cellular roles. Therefore, the label \u201cLipid and vitamin biosynthesis\u201d best captures the prevailing theme.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0030324","count":7},{"id":"GO:0006355","count":6},{"id":"GO:0009710","count":6},{"id":"GO:0042761","count":6}]},{"hash":"2277241952395154712","title":"Ectoine and Fatty Acid Metabolism Cluster","description":"Top GO terms reveal a core focus on ectoine biosynthesis and catabolism, along with methyl-branched fatty acid metabolism and fatty acid alpha-oxidation, indicating osmotic stress adaptation and lipid remodeling. The presence of verruculogen biosynthetic process hints at secondary metabolism but is less central. A few terms related to actin cytoskeleton and lamellipodium assembly appear, likely annotation noise rather than a shared cytoskeletal function across the cluster. Overall, the dominant theme is osmoprotectant and fatty-acid metabolism with some unrelated processes, suggesting a metabolic rather than structural design.","confidence":"Medium","size":12,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019491","count":8},{"id":"GO:0097089","count":7},{"id":"GO:0001561","count":7},{"id":"GO:0042400","count":7},{"id":"GO:1902181","count":7}]},{"hash":"457056111526510297","title":"Photoreceptor maintenance and dopaminergic signaling","description":"The cluster is strongly enriched for retina/photoreceptor terms (retina development, photoreceptor cell maintenance) and neural signaling (dopamine uptake regulation, ERK cascade), suggesting a photoreceptor-neuron functional theme; other terms likely reflect broader stress or immune responses but do not override the photoreceptor/dopaminergic focus.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060041","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0042742","count":5},{"id":"GO:0008283","count":5}]},{"hash":"1281811430928223443","title":"Glycosaminoglycan metabolism and xenobiotic detox","description":"These proteins are linked to glycosaminoglycan (heparan sulfate, dermatan sulfate, chondroitin sulfate) biosynthesis/metabolism and broader metabolic/detoxification pathways (bile acid catabolic, thyroid hormone, xenobiotic metabolism), with transcription and apoptotic terms playing a less central role. The common thread appears to be diverse metabolic processing, especially involving GAGs and xenobiotics, supporting this label.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0030573","count":2},{"id":"GO:0006044","count":2}]},{"hash":"1343132714221182932","title":"Adaptive immune activation (B and T cells)","description":"Proteins in this cluster are annotated with multiple immune-related GO terms, including immunoglobulin-mediated immune response, inflammatory response, B cell proliferation, T cell receptor signaling regulation, and cytokine-related pathways (IL-17), as well as signaling cascades like JNK. The convergence on adaptive immune processes and inflammation suggests a cohesive functional theme around immune activation and modulation, despite some noisy terms.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900275","count":2},{"id":"GO:0016064","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0032740","count":2}]},{"hash":"2178139719364361210","title":"Axon guidance and nerve localization","description":"The top GO terms are dominated by axon guidance across sensory and retinal ganglion cells, commissural neuron guidance, and axonogenesis, with additional terms for localization to paranode and juxtaparanode regions of axons and neural crest migration. This points to a cohesive neural development module centered on guiding axons and organizing nerve terminals. ","confidence":"High","size":12,"edges":21,"triangles":7,"max_degree":6,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0060385","count":6},{"id":"GO:0036486","count":5},{"id":"GO:0071679","count":5},{"id":"GO:0071205","count":5},{"id":"GO:1902336","count":5}]},{"hash":"1366326574575730901","title":"Ubiquitin-Dependent Signaling and Protein Turnover","description":"Top GO terms point to ubiquitination-driven regulation (autoubiquitination, K6-linked ubiquitination, ubiquitin-dependent protein catabolic process) intertwined with signaling pathways (TNF-mediated signaling, regulation of JNK cascade) and chromatin-related processes (histone catabolic process), suggesting a cohesive theme of ubiquitin-mediated control of signaling and protein turnover, with immune-related processes like V(D)J recombination contributing secondarily. This supports a label centered on ubiquitin-dependent regulation of signaling and turnover.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901253","count":10},{"id":"GO:1903762","count":10},{"id":"GO:0033209","count":10},{"id":"GO:0042787","count":10},{"id":"GO:0033151","count":10}]},{"hash":"946585706349181359","title":"RNA Processing and Spliceosome Regulation","description":"These proteins cluster around RNA maturation and post-transcriptional control: splicing regulation via the spliceosome (both positive and negative), mRNA polyadenylation/modification, mRNA stabilization, processome assembly, and translation reinitiation, with an additional link to ncRNA-mediated gene silencing and development. This coherent theme suggests a function in RNA processing and splicing control during early development.","confidence":"High","size":12,"edges":37,"triangles":38,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001825","count":10},{"id":"GO:0031047","count":10},{"id":"GO:1900363","count":10},{"id":"GO:0006378","count":10},{"id":"GO:0048255","count":10}]},{"hash":"1842944641116785238","title":"Neurodevelopment and innate immune signaling","description":"This set centers on axonogenesis (neural development) but also includes regulatory and stress-response processes such as modulation of protein kinases, proteolysis, chaperone-autophagy regulation, mitochondrial fission, and epithelial polarity; plus innate immune pathways (TLR9 signaling and IL-6 production). Together these terms suggest a broad signal-transduction cluster linking development with immune and cellular stress responses.","confidence":"Medium","size":12,"edges":9,"triangles":0,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007409","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0046938","count":4},{"id":"GO:0043085","count":4},{"id":"GO:1904715","count":4}]},{"hash":"1768650113541934853","title":"Ubiquitin-dependent proteolysis","description":"Most members are annotated to ubiquitin-dependent protein catabolic process, including K33-linked ubiquitination and regulation of ubiquitination, indicating a shared role in ubiquitin-mediated protein turnover. The other GO terms (muscle and kidney development, circadian rhythms) are less central, likely incidental. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0007519","count":7},{"id":"GO:0048741","count":7},{"id":"GO:1990390","count":7},{"id":"GO:2000312","count":7}]},{"hash":"949988896586520042","title":"NO signaling and vascular regulation","description":"Top terms point to nitric oxide\u2013mediated signaling (GO:0007263), regulation of systemic arterial blood pressure (GO:0003073), and positive regulation of angiogenesis (GO:0045766), all indicating a vascular/no signaling role. The presence of related terms like protein citrullination and arginine metabolism reinforces a link to arginine-derived NO and vascular regulation. A few terms concern unrelated processes (rRNA methylation, ubiquinone biosynthesis, selenium metabolism) or are obsolete, suggesting annotation noise or broad multifunctionality, but the core theme remains NO-driven vascular signaling.","confidence":"Medium","size":12,"edges":47,"triangles":78,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006656","count":2},{"id":"GO:0019546","count":1},{"id":"GO:0007263","count":1},{"id":"GO:0045766","count":1},{"id":"GO:0019547","count":1}]},{"hash":"1517206098958226900","title":"Multisubstrate membrane transporters","description":"The cluster is dominated by transmembrane transport GO terms across a variety of substrates, including nitrate/nitrite, galactose, fucose, sialic acid, phosphate ions, xenobiotics, and 4-hydroxyphenylacetate. This pattern points to membrane transporter proteins with broad substrate specificity. The single neural vesicle transport term is likely a related transport function or annotation artifact, but the overwhelming signal is transport across membranes, justifying the label.","confidence":"High","size":12,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":11},{"id":"GO:0098700","count":10},{"id":"GO:0006004","count":10},{"id":"GO:0035435","count":10},{"id":"GO:0015757","count":10}]},{"hash":"198207917465136649","title":"Ubiquitin-Mediated Innate Immune Regulation","description":"The cluster is dominated by GO terms linking ubiquitin-dependent protein catabolic processes and protein polyubiquitination with innate immune signaling (innate immune response, regulation of TLR signaling) and cell death pathways (regulation of necroptosis, apoptosis). This points to a cohesive theme where ubiquitination modulates immune signaling and programmed cell death, with a few developmental or cell-cycle terms appearing as broader regulatory connections. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0042787","count":7},{"id":"GO:0045087","count":6},{"id":"GO:0060544","count":6},{"id":"GO:0000209","count":6}]},{"hash":"1763925430900330666","title":"Golgi-ER vesicle transport and receptor trafficking","description":"The GO terms cluster around vesicle trafficking involving the Golgi and ER, including retrograde transport from endosome to Golgi, ER-to-Golgi transport, intra-Golgi transport, vesicle fusion with the Golgi, and Golgi ribbon formation, which points to core Golgi- and ER-associated cargo transport. The presence of terms related to synaptic receptor insertion and neuronal communication (e.g., postsynaptic receptor delivery, synaptic depression) suggests this trafficking activity is connected to receptor localization in neurons. Overall, the cluster reflects Golgi-mediated vesicular transport and receptor trafficking in neural contexts.","confidence":"High","size":12,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042147","count":2},{"id":"GO:0042144","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0048280","count":2},{"id":"GO:0090161","count":2}]},{"hash":"423367832196640795","title":"Unknown","description":"The proteins span a broad mix of GO terms including neural development, myelination, synapse assembly, cardiac muscle signaling, ear morphogenesis, immune defense, and general signaling pathways, with no single unifying function apparent. The lack of a cohesive functional theme or shared pathway suggests this is not a coherent cluster, hence Unknown. ","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0010881","count":2},{"id":"GO:0032474","count":2},{"id":"GO:0021859","count":2}]},{"hash":"1916326973377742729","title":"Acetylation-linked metabolism and chromatin regulation","description":"The cluster shows multiple acetylation-related processes (peptidyl-lysine N6-acetylation; spermine acetylation) alongside core metabolic pathways (glucosamine/N-acetylglucosamine metabolism; L-arginine biosynthesis; mycothiol biosynthesis) and a chromatin/heterochromatin term (subtelomeric heterochromatin formation). While some terms pertain to plant development (angiogenesis, leaf formation), the prevailing signal is acetylation-associated regulation of metabolism and chromatin state. ","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006044","count":12},{"id":"GO:0001525","count":12},{"id":"GO:0006348","count":12},{"id":"GO:2000025","count":12},{"id":"GO:0046208","count":12}]},{"hash":"122081001661547853","title":"TLR signaling and macrophage activation","description":"The cluster is characterized by strong enrichment for toll-like receptor pathways (TLR3 and TLR9) and downstream MyD88-dependent signaling, along with macrophage activation and defense responses to Gram-negative bacteria, suggesting a coherent innate immune and antimicrobial response. Some unrelated terms (e.g., odorant perception) appear but do not define the core theme.","confidence":"Medium","size":12,"edges":10,"triangles":0,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046827","count":4},{"id":"GO:0010754","count":4},{"id":"GO:0007608","count":4},{"id":"GO:0071321","count":4},{"id":"GO:0034162","count":3}]},{"hash":"34622915646392544","title":"Neural development and synapse assembly","description":"The strongest signals are neural-focused: corpus callosum development, axonal fasciculation, positive regulation of synapse assembly, and sensory perception of sound, pointing to neurodevelopment and synaptic wiring. Immune and vascular terms are present but appear less central, suggesting a main theme of neural development with some pleiotropic functions. Confidence: Medium.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0007205","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0097498","count":3},{"id":"GO:0006260","count":3}]},{"hash":"2001431123222408892","title":"Embryogenesis and tissue patterning with Wnt signaling","description":"GO terms center on embryonic development and tissue morphogenesis (left-right patterning, cartilage morphogenesis, endocardial cushion EMT, placenta and pancreatic/endocrine development) and are linked by the Wnt signaling pathway and transcriptional regulation. The cluster appears to group proteins involved in developmental patterning and organogenesis rather than a single mature cellular function, justifying a label focused on embryogenesis and patterning with Wnt signaling as a unifying theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060244","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3}]},{"hash":"2065575798617390099","title":"Complement and Coagulation Pathways","description":"The proteins cluster around classic and lectin complement activation, coagulation, and plasminogen activation/fibrinolysis, with associated collagen catabolic processes, suggesting a combined role in innate immunity and extracellular proteolysis/hemostasis. A minor term about axis specification is likely incidental. Confidence in the label is High.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0030574","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0007313","count":4}]},{"hash":"1708233663375321695","title":"Angiogenesis Regulation and Vascular Remodeling","description":"Based on the top GO terms, the cluster is driven by both positive and negative regulation of angiogenesis, VEGF signaling, and processes that modulate vascular remodeling (fibrinolysis/plasminogen activation), with immune and follicular contexts as supporting associations. This combination points to a cohesive theme of controlling blood vessel formation and turnover rather than a single isolated function.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0036066","count":2},{"id":"GO:0032026","count":2},{"id":"GO:2001113","count":2}]},{"hash":"2062200082375801479","title":"Adaptive immune differentiation and germinal center processes","description":"The top GO terms are dominated by adaptive immune functions: germinal center formation, regulation of IgE isotype switching, pro-T cell differentiation, type 2 immune response, and memory T cell differentiation, with some regulation of mast cell cytokines. Although a few terms pertain to non-immune processes (gravitropism, sarcomere organization, distal tubule morphogenesis, vesicle endocytosis), the strongest signal centers on adaptive immunity and lymphocyte development, justifying this label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002467","count":7},{"id":"GO:0048294","count":6},{"id":"GO:2000176","count":6},{"id":"GO:0042092","count":6},{"id":"GO:0009958","count":6}]},{"hash":"1171158343906226735","title":"Membrane trafficking and signaling regulators","description":"The top GO terms point to control of membrane-related processes: negative regulation of clathrin-dependent endocytosis, regulation of store-operated calcium channel activity, tail-anchored ER membrane insertion, and regulation of neurotransmitter secretion, suggesting a focus on membrane trafficking and calcium signaling. Additional terms like positive regulation of mitochondrial fusion and deubiquitination indicate broader protein turnover and organelle dynamics that can influence these membrane processes. While a few items (e.g., ribosomal subunit assembly, chromatin methylation) are more distant, the central theme remains regulation of intracellular transport and signaling. ","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0010216","count":3},{"id":"GO:0000028","count":3},{"id":"GO:0010636","count":3},{"id":"GO:1900186","count":3}]},{"hash":"115283462470546484","title":"Developmental signaling and myoblast fusion","description":"This cluster centers on embryonic development and tissue morphogenesis, with strong signals for cranial skeleton morphogenesis, telencephalon development, and multicellular organism development. The presence of myoblast fusion specifically points to muscle formation processes, while the DNA replication and translation regulation terms suggest proliferative, biosynthetic activity during development. Taken together, the proteins likely participate in early development with muscle formation and related signaling.","confidence":"High","size":11,"edges":26,"triangles":29,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":11},{"id":"GO:0006260","count":11},{"id":"GO:0038162","count":10},{"id":"GO:0007520","count":10},{"id":"GO:0021537","count":10}]},{"hash":"2274972644973725236","title":"GPCR-cAMP Signaling in Sensory Metabolism","description":"This cluster centers on GPCR-mediated cAMP signaling (activation of adenylate cyclase) and energy metabolism processes (thermogenesis, electron transport), with sensory functions spanning temperature response, pain perception, and vision (photoreceptor maintenance, visual learning). The combination suggests a unit where GPCR signaling links sensory inputs to metabolic and cardiovascular regulation (e.g., blood pressure). ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0010579","count":6},{"id":"GO:0008542","count":6}]},{"hash":"222875958349703369","title":"Innate immune lipid remodeling and leukotriene synthesis","description":"This cluster shows repeated enrichment for phospholipid remodeling (phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol), lipid catabolism, and leukotriene biosynthesis, alongside innate immune functions (neutrophil-mediated immunity, innate mucosal defense, defense against Gram-positive bacteria). The common theme is proteins involved in lipid remodeling that feed into inflammatory mediator production and innate immune responses.","confidence":"Medium","size":11,"edges":13,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006654","count":4},{"id":"GO:0010744","count":4},{"id":"GO:0002446","count":4},{"id":"GO:0002227","count":4},{"id":"GO:0036152","count":4}]},{"hash":"1550245681357475905","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042273","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0090669","count":2},{"id":"GO:0031120","count":2}]},{"hash":"1120995913456968080","title":"Ribosome biogenesis and cytoplasmic translation","description":"The cluster is dominated by GO terms for translation, cytoplasmic translation, ribosome biogenesis, and small subunit biogenesis, with additional hints of translational elongation regulation. These terms point to a core function in protein synthesis machinery, with some cell-cycle and stress-response associations likely reflecting broader cellular coordination rather than a separate process. Therefore, the label emphasizes ribosome assembly and cytoplasmic protein synthesis.","confidence":"High","size":11,"edges":13,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0042254","count":2},{"id":"GO:1901001","count":2},{"id":"GO:0014009","count":2}]},{"hash":"1874406262721832465","title":"Mitochondrial Transporters and Energy Regulation","description":"The proteins show strong enrichment for mitochondrial transmembrane transport (ornithine, citrate, thiosulfate, ATP) and for regulation of mitochondrial membrane potential, pointing to a core function in mitochondrial transport and energy homeostasis, with insulin- and amino acid\u2013related metabolic responsiveness as supportive context.","confidence":"High","size":11,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097421","count":3},{"id":"GO:0000002","count":2},{"id":"GO:0015886","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0000066","count":2}]},{"hash":"1836351931629212913","title":"Nuclear RNA processing and chromatin regulation","description":"The top GO terms cluster around RNA processing (RNA guanine-N7 methylation, viral mRNA export), transcription (DNA-templated transcription), and chromatin modification (histone methylation), pointing to a nuclear, gene-expression\u2013regulating focus. Some other terms are more divergent, but the strongest signals suggest RNA processing and chromatin regulation as the overarching theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:2001241","count":2},{"id":"GO:1900127","count":2},{"id":"GO:2000060","count":2},{"id":"GO:0001845","count":2}]},{"hash":"2184155791339269256","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000472","count":8},{"id":"GO:0000480","count":8},{"id":"GO:0000398","count":7},{"id":"GO:0000466","count":7},{"id":"GO:0000463","count":7}]},{"hash":"1724326009733646761","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:2001015","count":3},{"id":"GO:0060157","count":3},{"id":"GO:0000447","count":2},{"id":"GO:0000472","count":2}]},{"hash":"1396876182437101135","title":"Developmental transcriptional regulation","description":"This cluster centers on developmental processes across multiple tissues (heart, retina/RPE, placenta, adipose) and strong involvement in transcriptional control (DNA-templated transcription, RNA Pol II regulation, preinitiation complex assembly, ERK signaling), suggesting proteins that coordinate development through transcriptional regulation.","confidence":"High","size":11,"edges":13,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0070858","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0003406","count":2}]},{"hash":"15396060297287123","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0033209","count":2},{"id":"GO:1902474","count":1},{"id":"GO:1902354","count":1},{"id":"GO:0051932","count":1}]},{"hash":"531643771101074536","title":"Neural development with innate immune signaling","description":"This cluster is dominated by neural-development terms (synapse assembly, myelination, axonal fasciculation, otolith morphogenesis, multicellular development), suggesting a primary role in nervous system formation and connectivity. It also includes innate immune terms (lipopolysaccharide response, innate immune response, defense against bacteria), indicating some members may participate in immune signaling or inflammatory responses that intersect with neurodevelopment.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0071222","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0032474","count":5}]},{"hash":"607547434569545641","title":"APC-dependent mitotic protein degradation","description":"The dominant GO terms point to mitosis and ubiquitin-mediated turnover, notably APC-dependent catabolic processes, mitotic cell cycle, and cell division, along with K11-linked ubiquitination. While there are outliers (translation initiation complex formation, histone methylation regulation, cadmium response, SREBP signaling), the core pattern aligns with APC-driven protein degradation governing mitotic progression. Confidence: Medium","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:2001162","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0070979","count":3},{"id":"GO:0061087","count":3}]},{"hash":"749019893596929647","title":"Nuclear gene expression and RNA processing","description":"This cluster centers on DNA replication, transcription (DNA-templated) and its regulation, along with tRNA processing and RNA editing (A-to-I) and miRNA metabolism, all pointing to nuclear gene expression and RNA processing functions. While there are some metabolic and immune-related terms present, the strongest signal is RNA-related central dogma processes. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0008285","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0008033","count":3},{"id":"GO:0009398","count":2}]},{"hash":"1542610376450386623","title":"Redox metabolism and detoxification","description":"This cluster is dominated by redox-related GO terms (oxidation-reduction, redox homeostasis) and detoxification/xenobiotic responses (mercury detox, xenobiotic stimulus), with supporting metabolic processes such as glycolysis, propylene catabolism, and dihydrolipoamide metabolism. Together, these terms suggest a metabolic module centered on maintaining redox balance while processing diverse substrates, including detoxification pathways.","confidence":"High","size":11,"edges":10,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0042208","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0017000","count":3}]},{"hash":"2132885734768694253","title":"Peripheral nervous system development and myelination","description":"This cluster is dominated by GO terms related to nervous system development (including peripheral nervous system development and embryonic body morphogenesis), and by myelination and cell adhesion, suggesting roles in neural differentiation and the formation of myelin sheaths. While there are ancillary signals for angiogenesis and immune-related co-stimulatory processes, the strongest and most coherent theme centers on neural development and myelination. ","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":9},{"id":"GO:1904237","count":9},{"id":"GO:0001525","count":9},{"id":"GO:2000525","count":9},{"id":"GO:0007422","count":9}]},{"hash":"2285704136734295855","title":"Golgi vesicle trafficking and organization","description":"This cluster centers on Golgi apparatus functions and vesicle transport, including ER-to-Golgi and retrograde Golgi-ER transport, Golgi ribbon formation, and various forms of intracellular transport (Golgi to plasma membrane, and general protein transport). The presence of these GO terms suggests a cohesive theme around Golgi organization and vesicular trafficking, with some related roles in cell polarity, migration, and mitosis. ","confidence":"High","size":11,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0090161","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0090051","count":2},{"id":"GO:0006890","count":2}]},{"hash":"697291375027695154","title":"Multi-substrate membrane transporters","description":"Based on GO terms, these proteins are involved in various transmembrane transport processes, including nitrite/nitrate transport, sodium ion transport, vitamin and sialic acid transport, and xenobiotic movement, with a related role in neurotransmitter loading into synaptic vesicles. The shared theme is membrane transporters acting on diverse substrates rather than a single ligand.","confidence":"High","size":11,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":4},{"id":"GO:0006855","count":4},{"id":"GO:1900754","count":4},{"id":"GO:0015706","count":4},{"id":"GO:0042128","count":4}]},{"hash":"335696490891978845","title":"Systemic Stimulus Response and Cardiovascular Regulation","description":"The cluster shows frequent GO terms for responding to temperature, chemical stimuli, pain, and sensory cues (aerotaxis, vestibular development) together with cardiovascular-related processes (cardiac muscle action potentials, regulation of heart rate by cardiac conduction). This combination suggests a theme of organism-wide stimulus responses that interface with cardiovascular physiology, with additional developmental/metabolic context. ","confidence":"Medium","size":11,"edges":17,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":9},{"id":"GO:0097623","count":9},{"id":"GO:0050968","count":9},{"id":"GO:0021750","count":9},{"id":"GO:0002724","count":9}]},{"hash":"1634398267124837533","title":"Embryonic tissue development and differentiation","description":"The enriched GO terms center on developmental processes across multiple tissues (muscle precursor differentiation, cartilage condensation, liver development, sensory hair cell differentiation), suggesting a cohesive theme of embryonic tissue formation rather than a single specific pathway; some coagulation-related terms may reflect vascular development noise. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0051918","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0042730","count":3}]},{"hash":"2146608893417116755","title":"Vascular Remodeling and Anti-fibrotic Regulation","description":"The top GO terms cluster around vascular functions (blood vessel diameter maintenance, blood coagulation) and anti-fibrotic control (negative regulation of collagen biosynthetic process, hepatic stellate cell activation, fibroblast migration), with supporting notes on oxidative stress and metabolism (response to toxic substance, hydrogen peroxide catabolic process, oxygen transport, brown fat cell differentiation). This suggests a cohesive theme of tissue remodeling balancing vascular integrity and fibrotic processes, with metabolic/oxidative context.","confidence":"Medium","size":11,"edges":12,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0050880","count":1},{"id":"GO:0007596","count":1},{"id":"GO:0070293","count":1},{"id":"GO:0032966","count":1},{"id":"GO:2000490","count":1}]},{"hash":"758381099319531218","title":"Histone acetylation and heterochromatin formation","description":"The top GO terms center on histone modification and chromatin organization (peptidyl-lysine N6-acetylation, nucleosome assembly, rDNA and subtelomeric heterochromatin formation), suggesting chromatin regulation as the core function of the cluster.","confidence":"","size":11,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0018003","count":3},{"id":"GO:0006334","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0006044","count":2}]},{"hash":"460345904392642102","title":"Muscle development and differentiation","description":"This cluster centers on myogenesis and muscle structure, with terms like positive regulation of myoblast differentiation and sarcomere organization, plus Notch pathway modulation that promotes muscle differentiation; nervous system development also appears in development processes, and vasculogenesis may relate to coordinated tissue formation during muscle development.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045746","count":4},{"id":"GO:0045663","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0061428","count":2},{"id":"GO:0006351","count":2}]},{"hash":"610068072508218535","title":"Unknown","description":"The terms span neural/sensory processes (temperature response, pain perception, learning), calcium signaling, inflammatory response, and proteoglycan/ECM biosynthesis, with no single cohesive function linking all proteins; thus no clear theme is evident.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0051209","count":3}]},{"hash":"903254730324055243","title":"Mitotic Chromosome Cohesion and Segregation","description":"The prominent GO terms point to mitotic processes\u2014sister chromatid cohesion and APC-dependent chromosome separation\u2014indicating a cluster enriched for cell-cycle progression and chromosome management. Other terms reflect related cellular trafficking, but the mitotic signals dominate.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030042","count":8},{"id":"GO:0031081","count":8},{"id":"GO:0031145","count":8},{"id":"GO:0000070","count":8},{"id":"GO:0007064","count":8}]},{"hash":"267349615567852672","title":"Beta-Cell Development and Glucose-Triggered Insulin Secretion","description":"Most represented GO terms point to pancreatic beta-cell biology, including type B pancreatic cell development, proliferation, and regulation of insulin secretion in response to glucose, as well as glucose response. A DNA-templated transcription term supports an underlying gene-expression regulatory role linked to these processes. While some terms (hypoxia regulation, dsRNA transport, nitrite transport, sperm motility) appear less connected, the dominant pattern centers on beta-cell development and glucose-regulated insulin secretion.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900037","count":2},{"id":"GO:0048642","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0003323","count":1},{"id":"GO:0061178","count":1}]},{"hash":"343487841760308876","title":"B Cell Germinal Center Regulation","description":"The top GO terms cluster around modulation of B cell activity and germinal center dynamics, including immunoglobulin-mediated responses, regulation of B cell proliferation and isotype switching to IgA, and germinal center formation, with related hints of innate-adaptive signaling via TLRs. This points to a coherent theme of controlling antibody-producing B cell responses and germinal center processes, making the label appropriate.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016064","count":1},{"id":"GO:1902622","count":1},{"id":"GO:0030889","count":1},{"id":"GO:2000002","count":1},{"id":"GO:0048297","count":1}]},{"hash":"1143825327942802968","title":"Inflammatory signaling and angiogenic endothelial remodeling","description":"The GO terms point to inflammatory responses (including lipopolysaccharide response and inflammatory signaling) co-occurring with sprouting angiogenesis, endothelial cell migration/proliferation, and cell\u2013matrix/heterophilic adhesion. This suggests a coherent theme where immune/inflammatory cues drive vascular remodeling and endothelial dynamics during development or tissue response, justifying a label focused on inflammation-linked angiogenesis and endothelial remodeling.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:2001241","count":9},{"id":"GO:0006924","count":9},{"id":"GO:0007275","count":6},{"id":"GO:0006954","count":6},{"id":"GO:0071260","count":6}]},{"hash":"1251730365591108860","title":"Neuroimmune Signaling and Sensory Regulation","description":"The terms cover neural, immune, and sensory processes and their signaling pathways: vasopressin-related neuroendocrine regulation, opioid receptor signaling and cAMP/PKA control, cytokine production and dendritic cell differentiation, along with photoreceptor maintenance, temperature response, and coagulation. This points to a broad network of signaling activities spanning neural, immune, and sensory systems rather than a single, cohesive molecular function, justifying a label that captures cross-system signaling and sensory roles.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":7},{"id":"GO:0001992","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0032651","count":7},{"id":"GO:0097029","count":7}]},{"hash":"1275343593440739016","title":"GPCR signaling and calcium-driven vascular regulation","description":"This cluster centers on GPCR-mediated signaling with adenylate cyclase activation, calcium release, and GTPase regulation, linking receptor signals to vascular tone (blood pressure, vasoconstriction) and cell proliferation. Some terms like retina development and electron transport may reflect pleiotropic roles, but the dominant theme is calcium- and GPCR-driven signaling affecting vascular function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051209","count":3},{"id":"GO:0008284","count":2},{"id":"GO:0010579","count":2},{"id":"GO:0060041","count":2}]},{"hash":"1835485229897168199","title":"Unknown","description":"The top GO terms span several unrelated areas (muscle differentiation, insulin signaling and glucose transport, lipid storage, kidney basement membrane development, pancreatic cell development, IgA class switching, NF-kB regulation, and cell adhesion), with no single cohesive theme tying the proteins together; plus the cluster has no edges, suggesting no common function. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045662","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0048298","count":3},{"id":"GO:0032836","count":3},{"id":"GO:0003323","count":3}]},{"hash":"1489530140046737706","title":"Biomineralization and enamel formation","description":"This cluster is best described as biomineralization and enamel formation because the most represented terms are biomineral tissue development and amelogenesis, with supporting signals from extracellular matrix disassembly and Wnt signaling that point to mineralized tissue formation and enamel development rather than unrelated processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031214","count":4},{"id":"GO:0030194","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0060707","count":3},{"id":"GO:0007596","count":3}]},{"hash":"898499094899412924","title":"Unknown","description":"The terms are highly heterogeneous, including nervous-system related processes (visual perception, memory, grooming, nicotine response) alongside metabolic and immune terms (thiamine biosynthesis, macroautophagy, defense against fungus) and there are no edges connecting members (max degree 0). This lack of a cohesive, interpretable function prevents a meaningful specific label, so Unknown is appropriate.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009229","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0045415","count":2},{"id":"GO:0016236","count":2},{"id":"GO:0044130","count":2}]},{"hash":"1774788617338666417","title":"Apoptosis signaling in neurons and glia","description":"The top GO terms cluster around programmed cell death, including extrinsic signaling, execution phase, neuronal and glial apoptotic processes, and stress-related responses like hypoxia, with additional references to ERK pathway regulation. This suggests the proteins act together in apoptosis signaling within neural contexts, making a label centered on neuronal/glial apoptosis most representative.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0097194","count":2},{"id":"GO:0008635","count":2},{"id":"GO:0097192","count":2},{"id":"GO:0034349","count":2}]},{"hash":"1585440612262902554","title":"Regulation of Developmental Differentiation and Signaling","description":"The terms converge on developmental processes (blastocyst formation, myotube differentiation, osteoblast and fibroblast differentiation) and signaling pathways (BMP signaling, TGF-beta receptor signaling), with many entries pointing to negative regulation of growth and transcription. This suggests a theme of modulating development via signaling control, with a few entries (e.g., protein homotrimerization, DNA damage\u2013related apoptosis) as potential broader connective features. Overall, the cluster appears to reflect developmental differentiation regulation through signaling pathways.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":1},{"id":"GO:0070207","count":1},{"id":"GO:0010944","count":1},{"id":"GO:0030514","count":1},{"id":"GO:0048147","count":1}]},{"hash":"539384094308516859","title":"Heart development and developmental signaling","description":"The top GO terms show key developmental processes and signaling pathways, especially heart development (GO:0007507) and atrial septum morphogenesis, along with Wnt (GO:0016055) and Hippo (GO:0035332) signaling, and transcriptional regulation (GO:0045944). This suggests a coherent theme of organogenesis and growth control, with some outliers like seed development or visual learning likely reflecting broader developmental roles or annotation noise. Overall, the cluster appears centered on developmental signaling and heart-associated development.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0014834","count":1},{"id":"GO:0060216","count":1},{"id":"GO:0060195","count":1}]},{"hash":"921723917770056156","title":"Stress-Response Signaling and Transcription Regulation","description":"Top GO terms point to signaling pathway regulation (interferon, TGF-beta) and transcriptional control, with stress-related cues (hypoxia, ATP) and chaperone assembly, suggesting a cohesive cluster of signaling converging on transcription under stress. Some terms are peripheral (otolith tethering, obsolete linkage), but overall theme is signaling and transcription regulation in stress contexts.","confidence":"Medium","size":10,"edges":37,"triangles":70,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060338","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0030511","count":2},{"id":"GO:0070483","count":2},{"id":"GO:0051131","count":2}]},{"hash":"2182965217170217350","title":"ECM remodeling and angiogenesis","description":"Based on the GO terms, the proteins cluster around extracellular matrix (elastic fiber assembly, heparin proteoglycan biosynthesis) and vascular processes (angiogenesis, platelet aggregation, cell adhesion), with inflammatory signaling (interleukin-1 response, MIF pathway) also represented. This points to a cohesive theme of ECM remodeling in the context of angiogenesis and inflammation, even though one term (UV protection) is less directly connected. Overall, the cluster appears to reflect ECM-associated vascular remodeling and inflammatory signaling.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":3},{"id":"GO:0034116","count":2},{"id":"GO:0051005","count":2},{"id":"GO:0030210","count":2},{"id":"GO:2000446","count":2}]},{"hash":"1952339456888831832","title":"Xenobiotic Stress Response and Chromatin Regulation","description":"This cluster shows a clear enrichment for xenobiotic stimulus response terms, alongside regulatory/chromatin-related activities (chromatin binding regulation and histone demethylation) and signaling (cellular response to cAMP). While some metabolic terms are present, the dominant theme centers on environmental stress response coupled with chromatin-level regulation, suggesting a regulatory rather than purely enzymatic function.","confidence":"Medium","size":10,"edges":28,"triangles":39,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0034720","count":5},{"id":"GO:0071320","count":5},{"id":"GO:0060992","count":4}]},{"hash":"2240314400979423004","title":"Heart energy metabolism and calcium signaling","description":"GO terms indicate a cardiac module centered on calcium signaling (regulation of ryanodine receptor activity; SR Ca2+ release) and heart-type energy metabolism (beta-oxidation of fatty acids; leucine/valine catabolism), suggesting a functional theme of energy production tightly coupled to calcium handling in the heart.","confidence":"High","size":10,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0042594","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0042994","count":3},{"id":"GO:0060316","count":3}]},{"hash":"1812510226343995070","title":"DNA Replication and Transcription Regulation","description":"The top GO terms cluster around DNA replication steps (DNA topological change, unwinding, primer synthesis) and transcription initiation/clearance at RNA polymerase II promoters, suggesting proteins involved in DNA replication and transcription control. Additional terms related to DNA methylation, SOS response, and UV protection imply involvement in DNA damage response, reinforcing a theme of coordinating replication with transcription and genome stability.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006265","count":5},{"id":"GO:0000184","count":5},{"id":"GO:0009432","count":5},{"id":"GO:0006306","count":5},{"id":"GO:0006269","count":5}]},{"hash":"1067483455965264307","title":"Immune activation and organ/tissue development","description":"The top GO terms cover immune functions (complement activation, phagocytosis recognition, leukocyte tethering/rolling) and a suite of developmental processes (mesonephric/metanephric kidney development, lymph vessel morphogenesis, cartilage condensation, muscle regulation, and cuticle-related development). This suggests a cluster broader than a single pathway, encompassing both immune activation and various tissue/organ development processes.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0072177","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0048632","count":2},{"id":"GO:0006910","count":2}]},{"hash":"921556518704683971","title":"Cerebellar neural development and growth factor signaling","description":"The top GO terms strongly point to cerebellar development (cerebellar cortex formation, Bergmann glial differentiation) and axon regeneration regulation, suggesting a neural development-focused cluster. Additional growth-factor signaling terms (insulin receptor signaling, PDGF-related terms) indicate broader signaling context that supports development and proliferation. Some immune signaling terms appear but are less defining of the core theme, so the label centers on cerebellar neural development with growth factor signaling. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048679","count":8},{"id":"GO:0021697","count":8},{"id":"GO:0008286","count":8},{"id":"GO:0060020","count":8},{"id":"GO:2001275","count":8}]},{"hash":"1005338631295947561","title":"Hair cell synaptic signaling and cytoskeletal remodeling","description":"The top GO terms point to glutamate release and chemical synaptic transmission, especially in auditory hair cells (stereocilium organization), along with actin cytoskeleton organization and Rho signaling. The combination suggests a module centered on hair cell synapses and the underlying cytoskeletal dynamics that govern synaptic structure and signaling, with related junctional remodeling via adherens components and guanylyl cyclase\u2013related pathways.","confidence":"High","size":10,"edges":29,"triangles":32,"max_degree":9,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0014047","count":7},{"id":"GO:0090630","count":7},{"id":"GO:0030036","count":7},{"id":"GO:0043004","count":7},{"id":"GO:0007266","count":7}]},{"hash":"554234793693101450","title":"Neuronal proteostasis and mitochondrial dynamics","description":"Rationale: Several top GO terms consistently point to ubiquitin-dependent proteolysis (proteasomal catabolic process, polyubiquitination) and mitochondrial remodeling (fusion and fission), both of which are prominent in neuronal regulation. Additional terms related to neuron maturation and neuronal cellular homeostasis support a neuronal context, with transcription-related terms likely reflecting chromatin turnover in active neurons. Together, these themes suggest a cluster centered on neuronal proteostasis coupled to mitochondrial dynamics.","confidence":"High","size":10,"edges":4,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032436","count":5},{"id":"GO:0010636","count":4},{"id":"GO:1902530","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0070050","count":4}]},{"hash":"549262382376665228","title":"Bacterial lipid and quinone metabolism","description":"This cluster is dominated by lipid-related and quinone biosynthesis terms: fatty acid beta-oxidation, menaquinone and phylloquinone biosynthesis, as well as related catabolic and nutrient-responsive processes, with antibiotic biosynthesis appearing as a secondary feature. This points to an energy/metabolism module in bacteria rather than a single signaling pathway.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0010124","count":5},{"id":"GO:0006635","count":5},{"id":"GO:0009234","count":5},{"id":"GO:0042372","count":5}]},{"hash":"1895372332256552860","title":"DNA Replication and RNA Processing","description":"The top GO terms cluster around core DNA replication and DNA topology changes (replication, primer synthesis, unwinding, and chromatin context), suggesting a role in DNA maintenance. The presence of RNA processing terms (nonsense-mediated decay and spliceosome-mediated splicing) alongside replication-related terms points to a broader involvement in nucleic acid metabolism and processing, rather than a single, narrow function. Overall, the group appears to connect DNA replication/maintenance with RNA processing activities.","confidence":"Medium","size":10,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006265","count":9},{"id":"GO:0000184","count":9},{"id":"GO:0009432","count":9},{"id":"GO:0006306","count":9},{"id":"GO:0006269","count":9}]},{"hash":"866525927721907777","title":"Cell Cycle and Organ Development with Interferon Response","description":"This cluster centers on core cell cycle and developmental processes, with strong signals for mitosis (cell division, mitotic cell cycle) and organogenesis (atrial septum development, maintenance of animal organ identity), suggesting roles in proliferation and tissue differentiation. Additional terms point to broader signaling regulation and immune-related responses (cellular response to type I interferon, GPCR signaling regulation, steroid receptor assembly, photoreceptor localization), indicating a mix of developmental regulation and signaling, with an auxiliary immune component.","confidence":"Medium","size":10,"edges":5,"triangles":2,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:2001162","count":6},{"id":"GO:0003283","count":6},{"id":"GO:0071357","count":6},{"id":"GO:0048496","count":6}]},{"hash":"1020009247734016993","title":"Unknown","description":"Top terms point to varied developmental and cellular processes (animal organ development, multicellular development, anther morphogenesis) plus unrelated areas (spindle assembly, histone modification, T cell homeostasis) and some obsolete terms. This mix suggests no clear shared function or pathway for the cluster. Therefore, Unknown with confidence None. ","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061087","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0090308","count":2},{"id":"GO:0045869","count":2},{"id":"GO:0051225","count":2}]},{"hash":"2068440940590080734","title":"RNA Splicing Regulation and mRNA Stability","description":"This cluster is dominated by terms linked to mRNA splicing via the spliceosome, regulation of splicing, and mRNA stabilization/destabilization, indicating a coherent theme of post-transcriptional RNA processing and turnover; a developmental term is present but less central.","confidence":"High","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0010610","count":6},{"id":"GO:0000398","count":5},{"id":"GO:0045292","count":5}]},{"hash":"1837707907008452043","title":"Developmental differentiation and tissue morphogenesis","description":"GO terms indicate a focus on developmental processes and tissue formation, with spinal cord and seminiferous tubule development, osteoblast differentiation, and cell-matrix adhesion being prominent. While there are some ribosome maturation terms present, the dominant theme across the cluster is development and morphogenesis, supplemented by connections to angiogenesis and actin dynamics.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0000466","count":2},{"id":"GO:0072520","count":2},{"id":"GO:0001649","count":2}]},{"hash":"1077533444054867780","title":"Spliceosome-Driven mRNA Splicing Regulation","description":"The cluster is dominated by GO terms centered on mRNA splicing and its regulation via the spliceosome, including positive/negative regulation, cis and alternative splicing, and processome assembly, pointing to a cohesive RNA processing/regulatory theme.","confidence":"High","size":10,"edges":20,"triangles":15,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0001825","count":8}]},{"hash":"2114372124029041530","title":"Embryonic Heart and Placental Development","description":"These proteins appear linked to developmental processes, especially cardiovascular/heart formation (left-right patterning; endocardial cushion EMT; blood coagulation related to vascular development) and placental/organogenesis (trophoblast giant cell differentiation; placental development), plus pancreatic endocrine development and general growth. The immune defense term may be an outlier or reflect broader developmental-immune interactions, but the dominant theme is embryonic development and organogenesis. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0014909","count":3},{"id":"GO:0060972","count":2}]},{"hash":"1563141698982239541","title":"Transcription and Translation in Development","description":"The cluster is enriched for transcription (DNA-templated transcription) and translation initiation terms, with several development-related processes such as multicellular organism development and skeletal morphogenesis. Cytoskeletal remodeling (actin depolymerization) and GTPase regulation further suggest signaling linked to morphogenesis and growth, aligning gene expression with developmental processes.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0002188","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1105554168025018600","title":"Retinoid- and Lipid-Metabolism in Development","description":"The top GO terms cluster around retinoic acid biosynthesis, retinol metabolism, fatty acid elongation, sphingolipid biosynthesis, and very long-chain fatty acid biosynthesis, with lung development as a key process, suggesting a cohesive theme where retinoid signaling and lipid pathways coordinate development, particularly in the lung. Some terms (tropane alkaloid biosynthesis, phylloquinone catabolic process) appear as outliers or annotation noise, but the core theme centers on lipid and retinoid metabolism linked to development.","confidence":"Medium","size":10,"edges":6,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030324","count":8},{"id":"GO:0006355","count":8},{"id":"GO:0009710","count":8},{"id":"GO:0042761","count":8},{"id":"GO:0031427","count":8}]},{"hash":"1910267073646703221","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":2},{"id":"GO:0006469","count":2},{"id":"GO:2000778","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0006458","count":1}]},{"hash":"192700850767211574","title":"Ubiquitin-mediated regulation in muscle and immunity","description":"The top GO terms point to ubiquitin-dependent processes (ubiquitination, ubiquitin-dependent proteolysis) and their role in signaling (negative regulation of NF-kappaB transcription factor activity, transcription by RNA Pol II), alongside muscle-related terms (skeletal muscle cell differentiation, cellular response to mechanical stimulus) and innate immune response. This suggests a cluster of proteins involved in ubiquitin-driven regulation that links muscle physiology and innate immune signaling, possibly via mechanotransduction and NF-kappaB\u2013related pathways. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0035914","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0032088","count":3}]},{"hash":"1933143278599052138","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048903","count":2},{"id":"GO:0048012","count":2},{"id":"GO:0048008","count":2},{"id":"GO:0006458","count":1},{"id":"GO:0045454","count":1}]},{"hash":"2045775952530107694","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0001822","count":7},{"id":"GO:0006469","count":7},{"id":"GO:0045723","count":6}]},{"hash":"2031136773930837523","title":"Diverse Membrane Solute Transporters","description":"GO terms show multiple transmembrane transport activities across a range of substrates (nitrite, nitrate, sialic acid, xenobiotics, 4-hydroxyphenylacetate) and even neurotransmitter loading into synaptic vesicles, plus proton translocation and mitochondrial energy context. This pattern points to a cluster of membrane transport proteins handling diverse solutes, rather than a single substrate or pathway. Therefore a concise label is Diverse Membrane Solute Transporters.","confidence":"Medium","size":10,"edges":15,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006122","count":2},{"id":"GO:0009060","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0006855","count":2}]},{"hash":"903352372228611790","title":"Ubiquitin-dependent protein turnover and histone regulation","description":"This cluster is enriched for ubiquitin-dependent protein catabolic and histone catabolic processes, indicating a focus on proteostasis and histone turnover. Additional terms point to regulation of stress-responsive signaling (JNK, TNF) and apoptosis, suggesting a broader theme of ubiquitin-mediated degradation coordinating chromatin dynamics and cellular stress responses.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0036205","count":4},{"id":"GO:2000620","count":4},{"id":"GO:1901253","count":4},{"id":"GO:0033151","count":4}]},{"hash":"727801091755050743","title":"Retina photoreceptor development and neural axonogenesis","description":"These proteins show a pattern centered on photoreceptor biology (maintenance, outer segment organization, cone development) and broader neural development (neuron migration, CNS projection neuron axonogenesis, axon extension), implying a role in retinal photoreceptor differentiation and neurite outgrowth.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045494","count":1},{"id":"GO:0018105","count":1},{"id":"GO:0035845","count":1},{"id":"GO:0048675","count":1},{"id":"GO:0021860","count":1}]},{"hash":"680571119546118182","title":"Viral entry, replication, and virion assembly","description":"The top GO terms cluster around viral infection processes: fusion of viral membranes with host cells, uncoating, virion assembly, and RNA-templated DNA synthesis (reverse transcription), all core steps of the viral life cycle. Additional terms point to virus\u2013host interactions (symbiont entry, leukocyte migration) and viral exploitation of cellular contexts (lipid droplet organization). Together, they suggest a viral infection/replication theme rather than a single steady-state cellular process.","confidence":"Medium","size":10,"edges":33,"triangles":50,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0050900","count":1},{"id":"GO:0006278","count":1},{"id":"GO:0019064","count":1}]},{"hash":"1910164148007035786","title":"Central metabolism and vitamin biosynthesis","description":"This cluster centers on core metabolic pathways: glycolysis, the TCA cycle, and 2-oxoglutarate\u2013related metabolism, with notable amino acid catabolic processes (alanine and leucine). It also includes biosynthetic terms for vitamins (thiamine and cobalamin), suggesting a broader metabolic machinery rather than a single pathway. A regulatory term (cellular response to cAMP) co-occurs but does not define a distinct function for the group. Overall, the proteins appear tied to central carbon metabolism and vitamin biosynthesis activities.","confidence":"Medium","size":10,"edges":25,"triangles":18,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0009097","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0042853","count":2}]},{"hash":"1343312091785630595","title":"Transcriptional Regulation and Chromatin Remodeling","description":"The top GO terms point to core transcriptional control and chromatin context (DNA-templated transcription, nucleosome density/positioning), along with several differentiation-related processes (osteoblast/myotube differentiation and papilla formation). This suggests the proteins function as transcriptional regulators or chromatin remodelers that modulate gene expression during development and stress signaling (MAPK). Confidence: High","confidence":"","size":10,"edges":42,"triangles":98,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":9},{"id":"GO:0060766","count":9},{"id":"GO:0006351","count":7},{"id":"GO:0010832","count":7},{"id":"GO:0060303","count":7}]},{"hash":"1082042962898129640","title":"Aldehyde detox and carbohydrate metabolism with LPS response","description":"The Top Terms include a strong LPS response signal (immune-related) alongside several carbohydrate-related biosynthesis pathways (fructose, D-xylulose-5-phosphate) and aldehyde-detox (formaldehyde, furaldehyde) as well as retinoid metabolism and copper ion response. This pattern suggests a cluster centered on detoxification of aldehyde intermediates and carbohydrate metabolism, in the context of immune/stress responses. Confidence: Medium","confidence":"","size":10,"edges":17,"triangles":9,"max_degree":8,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0032496","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0046370","count":5},{"id":"GO:0042573","count":5},{"id":"GO:0033859","count":5}]},{"hash":"1668430684555384627","title":"Steroid and lipid hormone metabolism","description":"The top GO terms cluster around hormone-related biosynthesis and lipid signaling, including aldosterone biosynthesis and regulation of blood volume by aldosterone, vitamin D response and catabolism, and oxylipin biosynthesis, suggesting a shared theme of steroid and lipid hormone pathways. Some terms like isoquinoline alkaloid metabolic process are less directly connected, but the dominant pattern is lipid/steroid hormone metabolism.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":9},{"id":"GO:0031408","count":9},{"id":"GO:0010164","count":9},{"id":"GO:0032342","count":9},{"id":"GO:0002017","count":9}]},{"hash":"810147154240002231","title":"Mitochondrial outer membrane import and redox homeostasis","description":"The cluster centers on mitochondrial functions: outer membrane organization, translocase complex assembly, and protein targeting related to the mitochondrial outer membrane, alongside oxidative stress detoxification and redox balance. This points to a cohesive theme of mitochondrial protein import at the outer membrane and maintenance of redox homeostasis. Some terms (e.g., UV protection, muscle regeneration) may reflect broader cellular contexts or pleiotropic roles, but the mitochondrial theme is dominant.","confidence":"Medium","size":10,"edges":23,"triangles":31,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0045454","count":4},{"id":"GO:0030416","count":4},{"id":"GO:2000255","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1134646670623221226","title":"Unknown","description":"The top GO terms cover lipid metabolism, membrane homeostasis, sugar transport, epithelial maintenance, apoptosis, stress and immune responses, and even acrosome assembly, which are heterogeneous and do not point to a single coherent function for the cluster. This makes a precise, representative label difficult.","confidence":"","size":10,"edges":12,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030277","count":5},{"id":"GO:0097192","count":5},{"id":"GO:0070301","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0055091","count":5}]},{"hash":"633817071746282209","title":"Cholesterol-Linked Hedgehog Signaling in Development","description":"The most frequent terms cluster around cholesterol homeostasis and lipid metabolism, with regulators of Hedgehog signaling (negative regulation of Smoothened) and developmental processes (neural plate axis specification, epidermal differentiation). This suggests a cohesive theme where lipid metabolism intersects with Hedgehog pathway regulation to influence developmental patterning, with some insect cuticle-related terms indicating epidermal development and molting. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042632","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0043407","count":2},{"id":"GO:0006665","count":2},{"id":"GO:0021997","count":2}]},{"hash":"626749962460714516","title":"Unknown","description":"The top GO terms cover development (skeletal system, multicellular, retina), sensory functions (response to nutrient, taste perception), and diverse cellular/molecular processes (actin depolymerization, splicing, translational frameshifting, nuclear pore localization), with no clear common function linking them all.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007584","count":8},{"id":"GO:0048705","count":8},{"id":"GO:0030042","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0050909","count":8}]},{"hash":"272319537501629093","title":"Bacterial cell wall biosynthesis and division","description":"The top GO terms cluster around cell division and cell cycle, with multiple biosynthetic terms for the cell envelope such as peptidoglycan, cell wall polysaccharides, and capsule polysaccharide synthesis, indicating proteins involved in bacterial growth and envelope assembly. A few metabolism-related terms appear but are less central, suggesting they are secondary annotations. Overall, the theme is envelope biosynthesis linked to cell proliferation.","confidence":"Medium","size":10,"edges":13,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":7},{"id":"GO:1903457","count":6},{"id":"GO:0009252","count":6},{"id":"GO:0070592","count":6}]},{"hash":"1626291546948561946","title":"Immune-ECM remodeling in pregnancy","description":"This cluster combines immune-related processes (immunological synapse formation, innate immunity, Th17 regulation, apoptotic cell clearance) with extracellular matrix remodeling (fibronectin/collagen fibril organization) and EMT/endothelial changes, all of which are characteristic of tissue remodeling and angiogenesis in pregnancy contexts.","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001771","count":9},{"id":"GO:0045087","count":9},{"id":"GO:0001837","count":8},{"id":"GO:0007565","count":8},{"id":"GO:1905590","count":8}]},{"hash":"891657516988202818","title":"Mitotic cell cycle and ribosome biogenesis","description":"This cluster is dominated by mitosis and cell-cycle terms (cell division, mitotic cell cycle, metaphase/anaphase transition). Also present are RNA-processing/rRNA-modification hints (snoRNP assembly) and chromatin modulation (histone methylation), consistent with active cell growth. Immune response and photoreceptor localization terms are present but likely secondary. Overall, label reflects the cell-division-centric core of the cluster.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:2001162","count":2},{"id":"GO:0071357","count":2},{"id":"GO:1903546","count":2},{"id":"GO:0006463","count":2}]},{"hash":"627212795636795460","title":"Multisubstrate membrane transporters","description":"The GO terms point to transmembrane transport of diverse substrates\u2014nitrate/nitrite, various sugars (galactose, fucose), phosphate ions, xenobiotics, and sialic acid\u2014with an additional reference to neurotransmitter loading into synaptic vesicles, suggesting a cluster of membrane transporter proteins handling multiple substrates.","confidence":"High","size":10,"edges":19,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":10},{"id":"GO:0098700","count":6},{"id":"GO:0006004","count":6},{"id":"GO:0035435","count":6},{"id":"GO:0015757","count":6}]},{"hash":"640809077778160412","title":"Cardiac signaling and calcium-cAMP regulation","description":"This cluster is dominated by GO terms centered on heart development, regulation of cardiac muscle contraction, calcium release into the cytosol, and activation of adenylate cyclase with related cAMP signaling. Additional terms on GTPase activity regulation and protein phosphorylation support a broader signaling-control theme. While a couple terms relate to neural processes (visual perception, amphetamine response), the strongest and most recurrent themes point to cardiac signaling and calcium/cAMP\u2013mediated regulation of contraction and development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0008284","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0055117","count":3},{"id":"GO:0001975","count":3}]},{"hash":"389678251386571311","title":"Adhesion and migration with glial signaling","description":"The terms cluster around cell adhesion and migration (cell adhesion, colon epithelial cell migration, locomotory exploration behavior) and neural support signals (glial cell-derived neurotrophic factor receptor signaling pathway, positive regulation of oligodendrocyte differentiation), with a few general processes (hypoxia response, proteolysis, sphingomyelin catabolic process) that are common across contexts. This suggests a theme of adhesion and migration with accompanying neural/glial signaling cues, justifying the label, albeit acknowledging some heterogeneity. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0035641","count":2},{"id":"GO:0014846","count":2}]},{"hash":"637035589834917321","title":"Unknown","description":"The terms range from immune defense (Gram-positive response) and T cell proliferation to growth, metabolism (glucose homeostasis, nutrient response) and post-translational modification (hypusine) with no obvious common pathway or high-coherence function across the cluster. With no edges and mixed annotations, there is insufficient signal for a specific label.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0051289","count":1},{"id":"GO:0042593","count":1}]},{"hash":"750190291088500654","title":"Embryogenesis and placental development","description":"This cluster is dominated by embryonic development terms\u2014left/right patterning, endocrine system and placental/trophoblast differentiation, and morphogenesis of cartilage and other tissues\u2014covering broad organogenesis including pancreas development. The mix suggests a general developmental program rather than a single pathway, making a label focused on embryogenesis and placental formation appropriate.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060707","count":3}]},{"hash":"1255868793024249979","title":"GPCR-CAMP Signaling in Vascular and Immune Contexts","description":"Most represented terms point to GPCR signaling that activates adenylate cyclase and regulates cAMP-dependent kinase activity, with direct relevance to blood pressure control via vasopressin. Additional terms touch on photoreceptor maintenance and temperature response, suggesting GPCR roles in sensory and environmental signaling. Immune-related terms (IL-1\u03b2 production, dendritic cell differentiation) align with cAMP signaling influences on immune cell function. Therefore, the cluster is best described as GPCR-cAMP signaling across vascular, sensory, and immune contexts.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0045494","count":6},{"id":"GO:0001992","count":6}]},{"hash":"1402237195824247886","title":"Developmental morphogenesis and gene regulation","description":"This cluster shows a theme of organismal development, with terms like skeletal system morphogenesis, multicellular organism development, and retina development, alongside core gene-expression processes (DNA-templated transcription, mRNA splicing, translational control). Actin filament remodeling and sensory/nutrient response terms support morphogenesis and tissue maturation. Overall, the terms point to developmental morphogenesis governed by gene regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007584","count":4},{"id":"GO:0048705","count":4},{"id":"GO:0030042","count":4},{"id":"GO:0007275","count":4}]},{"hash":"2137871538048989063","title":"Mitochondrial Transport and Energy Regulation","description":"The proteins show strong enrichment for mitochondrial transmembrane transport (various substrates), regulation of mitochondrial membrane potential, and energy/metabolic signaling (insulin response and amino acid starvation), indicating a cohesive group involved in mitochondrial transport and metabolic control, potentially liver-related energy regulation.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":6},{"id":"GO:0015886","count":6},{"id":"GO:0032869","count":6},{"id":"GO:0000066","count":6},{"id":"GO:0097421","count":6}]},{"hash":"1183777782502582666","title":"Regulated cell-surface receptor signaling","description":"The cluster centers on modulation of membrane-based signaling, with GO terms for regulation of receptor signaling (including JAK-STAT), cell surface receptor signaling, and macrophage activation, plus related calcium signaling and phosphorylation regulation. A couple of terms about GPI anchor biosynthesis and fungal cell wall organization are more about biogenesis, but the dominant theme ties to signaling at the cell surface.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046425","count":1},{"id":"GO:0006506","count":1},{"id":"GO:0031505","count":1},{"id":"GO:0016255","count":1},{"id":"GO:0050976","count":1}]},{"hash":"183079227035940456","title":"B Cell Signaling and Adaptive Immunity","description":"The top GO terms cluster around adaptive immunity and B cell receptor signaling, with additional signals for innate immunity, IL-2 production, and core signaling pathways (Ras, PI3K, PLC, Rho) and cell adhesion. This points to a group of proteins involved in lymphocyte activation and immune signaling, particularly via B cell\u2013receptor\u2013mediated pathways, and broader immune communication.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002250","count":4},{"id":"GO:0051092","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0043552","count":3}]},{"hash":"393107491256590252","title":"Xenobiotic and hormone metabolism","description":"The cluster\u2019s GO terms center on metabolic processing of foreign compounds and signaling molecules, including xenobiotics, thyroid hormones, catecholamines, flavonoids, and related sugar and lipid-derived metabolites. Despite several terms being marked obsolete, the common thread is small-molecule and hormone metabolism rather than a single specific pathway, making this label a concise and representative summary of the cluster\u2019s functional theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015672","count":2},{"id":"GO:0030573","count":1},{"id":"GO:0006044","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0042403","count":1}]},{"hash":"1017487150488657832","title":"Integrin-mediated adhesion and immune signaling","description":"This cluster is dominated by GO terms tied to cell adhesion and signaling between cells, especially integrin-mediated pathways, heterotypic cell\u2013cell contact, and T cell activation, with related processes in cell migration and coagulation. Additional terms suggest broader proteostasis activities (proteasome assembly, ubiquitin-dependent degradation) that may reflect general protein turnover in these cells. A plant-specific term (stamen formation) appears as noise, but the core theme centers on adhesion-mediated communication and immune signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":8},{"id":"GO:0034113","count":6},{"id":"GO:0002291","count":6},{"id":"GO:0007596","count":6},{"id":"GO:1905050","count":6}]},{"hash":"490879945442004908","title":"Cardiovascular GPCR Signaling and Trafficking","description":"The terms cluster around GPCR signaling, receptor internalization, and cardiovascular-related processes (heart development, vasoconstriction, prostaglandin and hormone responses), with supporting themes in endosome organization and cytoskeletal dynamics. This suggests proteins involved in GPCR-mediated signaling affecting heart and vascular function, including receptor trafficking and lipid metabolism as ancillary aspects.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0071373","count":3},{"id":"GO:0002031","count":3}]},{"hash":"1770546759837112292","title":"DNA replication and genome maintenance","description":"The cluster is dominated by nuclear processes: DNA replication, DNA repair (UV-damage excision repair), telomere maintenance, centrosome cycle, and cell division, with additional signals from ribosomal biogenesis. These together point to core replication and genome maintenance machinery, though a development term (cranial skeleton morphogenesis) may reflect pleiotropic genes active in development. ","confidence":"High","size":9,"edges":8,"triangles":2,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0070914","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0010571","count":2},{"id":"GO:0000722","count":2}]},{"hash":"54630705589297444","title":"Unknown","description":"This cluster's GO terms span metabolism (alanine and thymidine catabolism), brain and gland development (pituitary gland and cerebral cortex), cell signaling and stress responses (nitric oxide response and ER-stress\u2013related apoptosis), transcription, and sperm capacitation, with no single dominant function tying them together, so a cohesive label cannot be assigned with confidence.","confidence":"","size":9,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":5},{"id":"GO:0021983","count":3},{"id":"GO:0045793","count":3},{"id":"GO:0071732","count":3},{"id":"GO:0070059","count":3}]},{"hash":"2175301832957287638","title":"Immune Signaling and Apoptosis Regulation","description":"These proteins show a cohesive emphasis on immune-related signaling and regulation of cell death: IL-12 response, regulation of mast cell degranulation, and tolerance induction to self antigen point to immune activation and immune tolerance; apoptotic pathways (programmed cell death, FGFR apoptotic signaling, anoikis regulation) suggest a link to cell fate decisions. Actin cytoskeleton remodeling further supports changes in immune cell movement and activation, tying the functional theme together, though some terms may reflect broader biology. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":9},{"id":"GO:0031532","count":9},{"id":"GO:1904531","count":9},{"id":"GO:2000811","count":9},{"id":"GO:0002651","count":9}]},{"hash":"1310797879871365044","title":"Plasma Membrane Ion Transport and Homeostasis","description":"The dominant terms describe movement of potassium and sodium ions across the plasma membrane and maintaining intracellular potassium homeostasis, pointing to a coherent function in ion transport and ionic balance at the cell surface. Some peripheral terms relate to muscle and immune contexts (T-tubule organization, cardiac hypertrophy regulation, T cell homeostasis), but the core theme remains membrane ion transport. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097623","count":2},{"id":"GO:0030007","count":2},{"id":"GO:1990573","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0036376","count":1}]},{"hash":"223082245864887449","title":"Immune Signaling and Transcription Regulators","description":"Top GO terms suggest involvement in innate and adaptive immune signaling (innate immune response, LPS response, GM-CSF signaling, T cell receptor signaling) as well as transcriptional regulation (DNA-templated transcription) and various signaling pathways (insulin receptor). The presence of developmental terms (inner ear, forebrain) alongside broad signaling and transcription terms indicates these proteins are regulators participating in diverse signaling and transcriptional control rather than a single, cohesive pathway. This leads to a label that emphasizes regulatory roles in immune signaling and transcription.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0046777","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0097011","count":2}]},{"hash":"2205702328297190186","title":"Embryonic Morphogenesis and Proliferation","description":"These proteins cluster around developmental processes: cranial skeleton morphogenesis, telencephalon and multicellular organism development, and myoblast fusion, suggesting roles in embryogenesis and tissue formation. The presence of DNA replication and signaling/translation regulation terms indicates concurrent cell proliferation and growth signals typical of developing tissues, rather than a single specific pathway.","confidence":"Medium","size":9,"edges":5,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":9},{"id":"GO:0006260","count":9},{"id":"GO:0038162","count":8},{"id":"GO:0007520","count":8},{"id":"GO:0021537","count":8}]},{"hash":"1777814347679087855","title":"Vertebrate Development and Signaling","description":"The most represented terms point to vertebrate development (forebrain, skeletal system, multicellular development) and to signaling and transcription processes (GTPase signaling, tyrosine phosphorylation, DNA-templated transcription), with contexts of vitamin D and hypoxia responses. This suggests the cluster comprises developmentally active regulatory proteins.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007568","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0033280","count":4}]},{"hash":"1109856635989288917","title":"Actin Cytoskeleton Remodeling and Apoptosis","description":"This cluster is dominated by GO terms related to actin cytoskeleton organization, lamellipodium and actin filament bundle assembly, indicating a strong theme of actin dynamics and cell movement. The presence of apoptotic process suggests a link between cytoskeletal remodeling and programmed cell death. Some development-related terms (cerebellum morphogenesis, parathyroid gland development) may reflect broader developmental roles of actin dynamics, while peroxisomal protein import docking and other terms could be ancillary associations. ","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0051017","count":4},{"id":"GO:1900740","count":4},{"id":"GO:0030032","count":3},{"id":"GO:0016560","count":3}]},{"hash":"2247133727085543057","title":"ER organization and nuclear envelope dynamics","description":"The top GO terms are dominated by endoplasmic reticulum processes (inheritance, tubular network organization, ER stress response) and nuclear envelope functions (nuclear pore complex assembly, mitotic nuclear membrane reassembly), with ER-linked peroxisome organization and membrane trafficking also present; a couple of terms (taste perception, ABA response) appear as noise but do not override the ER/nuclear envelope theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048309","count":1},{"id":"GO:0051292","count":1},{"id":"GO:0050913","count":1},{"id":"GO:0034976","count":1},{"id":"GO:0032581","count":1}]},{"hash":"1276358133802730020","title":"Ubiquitin-Proteasome Regulation of Mitosis","description":"The top terms center on ubiquitin-dependent protein degradation (SCF and APC/C pathways, K11-linked ubiquitination) that controls mitotic transitions (G2/M, anaphase, exit from mitosis). This suggests a cohesive cluster of proteins involved in ubiquitin-mediated proteolysis during cell cycle progression, with additional but weaker hints of broader developmental or stress-related processes.","confidence":"High","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":9},{"id":"GO:0070979","count":8},{"id":"GO:0000086","count":8},{"id":"GO:0016032","count":7},{"id":"GO:0070911","count":7}]},{"hash":"406752497928397249","title":"Retroviral entry, genome integration, and latency","description":"The GO terms strongly point to a retroviral life cycle: entry into host cells, reverse transcription (RNA-templated DNA synthesis), integration of viral DNA into the host genome, establishment of proviral latency, plus related DNA replication and recombination and suppression of host RNA silencing. This combination best captures the cluster\u2019s function.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039651","count":2},{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0046718","count":2}]},{"hash":"365128923067785466","title":"Unknown","description":"The GO terms span chromatin-related processes (nucleosome assembly) and DNA damage responses (DSB repair via HR/SSA) alongside a mix of developmental terms (visual learning, nipple morphogenesis, lung connective tissue development, blastocyst hatching) and cell-cycle checkpoints, with no observed edges or cohesive functional linkage among the proteins. Because there isn\u2019t a single clear theme tying these functions together, a safe label is Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0010792","count":1}]},{"hash":"776941350128166560","title":"Immune Signaling and Regulation","description":"The top GO terms cluster around adaptive immune signaling and lymphocyte differentiation, including B cell receptor signaling, type 2 immune response, regulation of IgE isotype switching, and pro-T cell differentiation. A smaller group of terms pertains to core gene expression processes (translation initiation and mRNA splicing), which may reflect general cellular machinery present in many proteins. Overall, the dominant theme is immune signaling and regulation, justifying this label.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0001732","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0006413","count":1},{"id":"GO:0000398","count":1}]},{"hash":"2133557676672061699","title":"Mitotic spindle and chromosome segregation regulation","description":"Based on the GO terms, the proteins cluster around mitosis-related processes: localization to the spindle pole body and kinetochore, regulation of sister chromatid biorientation, septation signaling, and general control of mitotic events. While there are a few outliers (circadian rhythm, postsynaptic density), the dominant theme is spindle/kinetochore function and chromosome segregation during cell division.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902406","count":8},{"id":"GO:0007623","count":8},{"id":"GO:0070373","count":8},{"id":"GO:1990975","count":8},{"id":"GO:0097107","count":8}]},{"hash":"339165859701779134","title":"Post-transcriptional RNA processing and translation control","description":"The top GO terms cluster around post-transcriptional regulation: splicing (alternative and negative regulation via spliceosome), mRNA polyadenylation and modification, mRNA stabilization, and translation reinitiation, with an additional note of small-subunit processome assembly linked to ribosome biogenesis. Together these imply a function focused on RNA maturation and control of gene expression at the RNA level, including translation readiness.","confidence":"High","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001825","count":5},{"id":"GO:0031047","count":5},{"id":"GO:1900363","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0048255","count":5}]},{"hash":"689797811902007750","title":"Ubiquitin-Dependent Degradation and Autophagy","description":"This cluster is dominated by GO terms for ubiquitin-mediated protein turnover (ERAD, ubiquitin-dependent catabolic process, protein polyubiquitination) and autophagy, pointing to a cohesive function in protein quality control and degradation pathways, with secondary links to immune signaling through NF-kappaB regulation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0000209","count":5},{"id":"GO:0002635","count":4}]},{"hash":"1114920522188341580","title":"Unknown","description":"The GO terms span lactation, negative regulation of vasculogenesis/ VEGF signaling and endothelial differentiation, plus diverse metabolic processes (ferrodoxin, phenylacetate, xanthine catabolism), sodium transport, and ATP-linked electron transport. The set lacks a single coherent function tying the proteins together, making it hard to assign a specific, representative label beyond Unknown.","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007595","count":3},{"id":"GO:2001213","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0006124","count":3},{"id":"GO:0006814","count":3}]},{"hash":"493257914924087953","title":"Dopamine GPCR Signaling and Phototransduction","description":"The top GO terms converge on GPCR-mediated signaling driven by dopamine receptors (adenylate cyclase-activating pathways and adrenergic-like signaling) and on retinal phototransduction (phototransduction, photoreceptor maintenance), with links to PLC activation and cAMP-related processes. While a couple terms (heart development, viral release) are less related, the dominant pattern points to a GPCR signaling module centered on dopamine signaling and photoreceptor physiology, justifying this label as the cluster\u2019s core theme. ","confidence":"Medium","size":9,"edges":5,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007191","count":5},{"id":"GO:0007603","count":5},{"id":"GO:0060158","count":5},{"id":"GO:0010513","count":5}]},{"hash":"1181198039383612928","title":"EMT and ECM remodeling in development","description":"The cluster is dominated by epithelial-to-mesenchymal transition, fibronectin and collagen fibril organization, and integrin signaling, with associated endothelial proliferation and somite development, indicating ECM-driven tissue morphogenesis and vascular development. Immune-related terms are present but do not override the core theme of EMT/ECM remodeling during development.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001837","count":5},{"id":"GO:1905590","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0001935","count":5},{"id":"GO:2001046","count":5}]},{"hash":"429058449584964617","title":"Plant phenylpropanoid metabolism","description":"The top GO terms cluster around flavonoid biosynthesis (kaempferol/quercetin/cyanidin glucosides) and lignin metabolism, key components of the phenylpropanoid pathway, suggesting the proteins function in plant secondary metabolite production. Some terms (e.g., paranode localization) appear unrelated noise and do not define the main theme. ","confidence":"High","size":9,"edges":15,"triangles":4,"max_degree":6,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0002175","count":6},{"id":"GO:0033330","count":5},{"id":"GO:0033303","count":5},{"id":"GO:0009808","count":5},{"id":"GO:0033485","count":5}]},{"hash":"1571182886017001931","title":"Chromatin remodeling and cytoskeletal organization","description":"This cluster features chromatin-related terms (histone acetylation, nucleosome mobilization, heterochromatin formation) alongside cytoskeleton-related terms (Arp2/3 actin nucleation, sarcomere organization) and related processes like endocytosis and calcium response, suggesting a shared theme of coordinating chromatin state with cytoskeletal dynamics in development and cell division.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0016344","count":8},{"id":"GO:0009825","count":8},{"id":"GO:0043983","count":8},{"id":"GO:0034314","count":8},{"id":"GO:0042766","count":8}]},{"hash":"1615763294146303438","title":"Ubiquitin-dependent protein degradation","description":"GO terms converge on ubiquitin\u2011dependent protein catabolic processes, including K6\u2011linked ubiquitination, autoubiquitination, and histone catabolic process, pointing to regulated protein turnover and chromatin remodeling. Additional terms hint at downstream effects on cell cycle and signaling pathways (TNF, neuronal apoptosis), consistent with ubiquitin's role in proteostasis and pathway regulation. A few terms appear tangential (viral replication, exploration behavior) but do not override the central ubiquitin-proteolysis theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0090394","count":2},{"id":"GO:0019079","count":2},{"id":"GO:0035640","count":2},{"id":"GO:1903378","count":2}]},{"hash":"1306071495102387606","title":"Unknown","description":"These nine proteins are linked to a wide range of GO terms spanning photoreceptor maintenance, vasopressin-mediated blood pressure regulation, cellular response to temperature, IL-1 beta production, dendritic cell differentiation, cell proliferation, PKA activity modulation, blood coagulation, sensitization, and opioid receptor signaling that inhibits adenylate cyclase. The diversity suggests no single cohesive biological function or pathway common to all members, making it difficult to assign a specific label beyond Unknown.","confidence":"","size":9,"edges":18,"triangles":19,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":5},{"id":"GO:0001992","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0032651","count":5},{"id":"GO:0097029","count":5}]},{"hash":"1996869546083604709","title":"Developmental signaling and immunity","description":"GO terms in the cluster center on development (brain and nervous system), cell proliferation, angiogenesis, and immune responses, with positive regulation of ERK1/2 signaling as a recurring mechanism. This combination suggests proteins involved in developmentally regulated signaling pathways that also intersect innate and adaptive immunity, hence a label reflecting both developmental signaling and immune functions.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007420","count":3}]},{"hash":"1946760917337399669","title":"Lipid metabolism and prostaglandin-vascular signaling","description":"This cluster centers on lipid-related processes such as triglyceride metabolism and fat cell differentiation, along with prostaglandin biosynthesis and vascular-related functions like vasodilation and endothelial cell development. Together, these terms point to a lipid signaling axis that modulates vascular function and tissue remodeling (including skeletal muscle regeneration). Oxidant detoxification and xenobiotic responses are present but secondary to the lipid/prostaglandin-vascular theme.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0006641","count":5},{"id":"GO:0001516","count":4},{"id":"GO:0009650","count":3},{"id":"GO:0043403","count":3}]},{"hash":"818402116993445808","title":"ESCRT-driven MVB formation and protein sorting","description":"The cluster\u2019s top GO terms cluster around ubiquitin-dependent cargo sorting into multivesicular bodies and ESCRT-mediated vesicle formation (MVB assembly and related sorting pathways). Some viral budding terms reflect the host ESCRT involvement in budding. A few development terms appear broad, but the dominant pattern points to ESCRT/MVB trafficking and ubiquitin-based degradation. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0001731","count":2},{"id":"GO:1902188","count":1}]},{"hash":"1808811964162645620","title":"Organogenesis and cell adhesion","description":"The top GO terms cluster around cell adhesion (cell-matrix and heterophilic cell-cell adhesion) and cell migration involved in angiogenesis, alongside development of organs (lung, heart, kidney) and neural guidance. This suggests a cohesive theme of tissue morphogenesis and organ formation driven by adhesion and migration, with a minor link to immune-related complement activity. Confidence is Medium.","confidence":"","size":9,"edges":10,"triangles":2,"max_degree":5,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0007160","count":6},{"id":"GO:0006590","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0090050","count":6}]},{"hash":"88977048600554263","title":"Unknown","description":"The GO terms span lipid metabolism (unsaturated/monounsaturated fatty acids, ergosterol-related processes) and skin/gland-related development (tarsal sebaceous gland-like terms), plus unrelated processes (nitrate assimilation, CNS myelin maintenance) with no single coherent functional theme across the cluster. This lack of a common function makes it inappropriate to assign a specific label, so the cluster is Unknown.","confidence":"","size":9,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":1},{"id":"GO:0032443","count":1},{"id":"GO:0032286","count":1},{"id":"GO:1903966","count":1},{"id":"GO:0070542","count":1}]},{"hash":"1794995988029222621","title":"Steroid hormone and lipid signaling","description":"The terms show a strong connection to steroid hormones (aldosterone biosynthesis and renal volume regulation) and vitamin D signaling, plus oxylipin biosynthesis as lipid mediators. Although there are immune and mammary development notes, the central pattern points to endocrine regulation and lipid-based signaling networks.","confidence":"Medium","size":9,"edges":8,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":4},{"id":"GO:0031408","count":4},{"id":"GO:0010164","count":4},{"id":"GO:0032342","count":4},{"id":"GO:0002017","count":4}]},{"hash":"2280205029268623547","title":"Innate Immune Signaling and Cell Death Regulation","description":"GO terms center on innate immune response and defense against virus, with regulation of necroptosis, apoptosis, and Toll-like receptor signaling; polyubiquitination supports signaling turnover. Some terms (transcription regulation, histone methylation, atrial septum development) are less connected, but the dominant theme links innate immune signaling to control of cell fate.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0000209","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060544","count":2}]},{"hash":"2275769318791190297","title":"Translational Initiation Regulation","description":"The cluster shows enrichment for cytoplasmic translational initiation and regulation of translational initiation, pointing to a common theme of controlling protein synthesis initiation, even though other terms in the set are more disparate.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":2},{"id":"GO:0043547","count":1},{"id":"GO:0071732","count":1},{"id":"GO:0019284","count":1},{"id":"GO:1903833","count":1}]},{"hash":"1688643176594067511","title":"Collagen ECM Organization and Skin Development","description":"The terms point to extracellular matrix construction (collagen fibril organization, integrin biosynthesis, collagen-activated signaling) and tissue morphogenesis (skin and cartilage development). While a complement activation term is present, the strongest and most recurrent themes are ECM remodeling and skin/cartilage morphogenesis, supporting a label centered on collagen/ECM and skin development.","confidence":"High","size":9,"edges":12,"triangles":7,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0030199","count":4},{"id":"GO:2000860","count":3},{"id":"GO:0045112","count":3},{"id":"GO:0033034","count":3}]},{"hash":"1491070915048769188","title":"Metal stress and ubiquitin-mediated proteolysis","description":"This cluster is driven by GO terms for cellular responses to cadmium and methylmercury, and by ubiquitin-dependent protein degradation pathways (SCF-dependent ubiquitin-proteasomal degradation, protein ubiquitination, polyubiquitination). These together point to a coherent theme of stress-induced proteostasis and protein quality control under metal/oxidative stress. Some terms about DNA replication regulation and mitochondrial complex IV assembly may reflect secondary connections to cell cycle checkpoints and mitochondrial maintenance during stress, but the dominant signal is metal stress coupled with ubiquitin-mediated proteolysis.","confidence":"High","size":9,"edges":12,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0033617","count":2},{"id":"GO:0031571","count":1},{"id":"GO:0031146","count":1},{"id":"GO:0030174","count":1}]},{"hash":"1491893311546686975","title":"Ubiquitin-Dependent Proteolysis and Autophagy","description":"The top terms are dominated by ubiquitin-dependent protein catabolic process and autophagy, with additional regulatory links to signaling pathways and immune-related processes (NLRP3 inflammasome, I-kappaB phosphorylation, LPS signaling) and nuclear/chromatin dynamics (PML body organization, histone catabolic process). This points to a cohesive theme of protein turnover via ubiquitin-proteasome and autophagy pathways, modulating cellular signaling and innate immune responses, so the label captures the cluster\u2019s core function.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0006914","count":8},{"id":"GO:1900458","count":8},{"id":"GO:1900226","count":8},{"id":"GO:0045869","count":8}]},{"hash":"2243496671496997458","title":"Neural development and glutamatergic signaling","description":"The top terms cluster around neural development and synaptic function: corticospinal tract morphogenesis, positive regulation of glutamatergic synaptic transmission, and learning. There are other terms like Rho signaling and immune-related processes that might reflect multifunctional proteins or annotation noise, but the dominant theme is neuronal development and synaptic activity.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0035024","count":2},{"id":"GO:0021957","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0007612","count":2}]},{"hash":"1051306141658490925","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090073","count":3},{"id":"GO:0034145","count":2},{"id":"GO:0045410","count":2},{"id":"GO:0002781","count":2},{"id":"GO:0070935","count":2}]},{"hash":"671474352968342028","title":"Telomere maintenance and DNA repair","description":"Dominant signals are telomere maintenance (telomerase-related) and several DNA repair pathways (base-excision repair, alkylation repair, translesion synthesis). A few terms on estradiol response and gonad development appear but are secondary to the core telomere/DNA repair theme.","confidence":"High","size":9,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051973","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0002526","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0033158","count":1}]},{"hash":"192056727461294957","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0008360","count":2},{"id":"GO:0009252","count":2},{"id":"GO:0033076","count":2},{"id":"GO:0034354","count":2}]},{"hash":"848644394097326383","title":"Cardiac Development and Transcriptional Regulation","description":"The cluster's top terms include heart development and atrial septum morphogenesis, pointing to cardiac-related functions, with additional signals for muscle regeneration and DNA-templated transcription, suggesting transcriptional regulatory activity (including chromatin-related processes). This combination supports a label focused on cardiac development and gene regulation.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0014834","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0043433","count":1}]},{"hash":"1618215720476071045","title":"Steroid Hormone and Vitamin D Metabolism","description":"The cluster\u2019s terms cluster around steroid hormone biosynthesis (aldosterone), secosteroid metabolism (vitamin D), and related physiological processes (blood volume regulation, mammary gland development). Lipid-derived signaling (oxylipins) also features, supporting a theme of steroid/ lipid hormone metabolism and hormone-mediated regulation. Confidence: Medium","confidence":"","size":9,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":4},{"id":"GO:0031408","count":4},{"id":"GO:0010164","count":4},{"id":"GO:0032342","count":4},{"id":"GO:0002017","count":4}]},{"hash":"1703239540383385464","title":"Vascular Calcium-GPCR-Rho Signaling and Adhesion","description":"The cluster\u2019s top terms center on calcium ion regulation, GPCR signaling (adenylate cyclase-activating pathways), and Rho signaling, complemented by adhesion-related processes (integrin signaling, receptor clustering, heterotypic cell\u2013cell adhesion) and blood pressure regulation. Although a few terms like electron transport chain and memory are peripheral, the dominant theme ties signaling cascades to vascular adhesion and regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007204","count":2},{"id":"GO:0010579","count":2},{"id":"GO:0035025","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0045777","count":2}]},{"hash":"470865916576707019","title":"ER and Nuclear Envelope Organization","description":"Most terms cluster around endoplasmic reticulum structure and function (inheritance, tubular network organization, ER stress response) and around nuclear envelope dynamics (nuclear pore complex assembly, mitotic nuclear membrane reassembly). Additional terms about ER-dependent peroxisome organization and protein transport into membrane rafts support a broader theme of membrane organization and trafficking. Some terms (taste perception) seem unrelated noise, but the dominant ER/nuclear envelope signals suggest this label is representative.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048309","count":1},{"id":"GO:0051292","count":1},{"id":"GO:0050913","count":1},{"id":"GO:0034976","count":1},{"id":"GO:0032581","count":1}]},{"hash":"1968583729125930660","title":"RNA processing and translation regulation","description":"The strongest signals are RNA-related processes (guanine-N7 methylation, mRNA splicing, and translational frameshifting regulation), suggesting post-transcriptional control as the core function; the developmental terms appear as broader context rather than the primary cluster theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036265","count":4},{"id":"GO:0007584","count":3},{"id":"GO:0048705","count":3},{"id":"GO:0030042","count":3},{"id":"GO:0007275","count":3}]},{"hash":"2110808949422567933","title":"Fatty acid oxidation and branched-chain amino acid catabolism","description":"This cluster is dominated by GO terms for fatty acid beta-oxidation, long-chain fatty acid catabolism, and carnitine metabolism, alongside leucine and valine catabolic processes, pointing to energy generation through lipid and branched-chain amino acid catabolism. Temperature response terms are present but secondary to the core metabolic theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009409","count":2},{"id":"GO:0009408","count":2},{"id":"GO:2000253","count":1},{"id":"GO:0018095","count":1},{"id":"GO:0060296","count":1}]},{"hash":"1091207484260333411","title":"Brain development and energy metabolism","description":"Top terms suggest a focus on neural development (substantia nigra and cerebellum development, brain development) with concurrent involvement in energy metabolism (creatine/phosphocreatine biosynthesis/metabolic process) and neuronal signaling (chloride ion homeostasis, phosphorylation). This combination points to proteins linked to brain maturation and the metabolic/ionic regulation essential for neural activity, supporting a coherent label around neural development and brain energy/ion homeostasis.","confidence":"Medium","size":9,"edges":10,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0031666","count":2},{"id":"GO:0006478","count":1},{"id":"GO:0046314","count":1},{"id":"GO:0021762","count":1},{"id":"GO:0021549","count":1}]},{"hash":"341822607010939540","title":"Developmental growth and ER-stress\u2013driven apoptosis","description":"These proteins cluster around developmental processes (brain/forebrain, multicellular growth) and ER-stress\u2013driven apoptosis, with ubiquitination and retrograde ER-Golgi transport suggesting a role in proteostasis during development. The mix of developmental and stress-response terms supports a generic developmental-growth with ER-stress signaling rather than a single tissue-specific function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0010659","count":3}]},{"hash":"437598330450145577","title":"Aromatic compound degradation with biotin/antibiotic biosynthesis","description":"The cluster is enriched for biotin biosynthesis and antibiotic biosynthetic processes, and includes aromatic compound degradation pathways (3-phenylpropionate catabolic process and beta-ketoadipate pathway). Additional terms like nitrogen utilization and response to toxic substances point to a metabolism-focused theme. Together, these suggest a cohesive set of proteins involved in aromatic metabolism and production of small molecules, justifying the label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0019380","count":3},{"id":"GO:0042952","count":3},{"id":"GO:0097755","count":3}]},{"hash":"1181747937190929174","title":"TLR-NF-\u03baB Cytokine Signaling","description":"Dominant GO terms point to innate immune signaling via Toll-like receptor pathways (TLR3 and TLR9), NF-\u03baB activation (I-kappaB phosphorylation), and cytokine production (IL-6 and IFN-\u03b1). While some terms touch on development and differentiation, the strongest enrichment is clearly immune-related, indicating NF-\u03baB\u2013driven inflammatory signaling as the core function of this cluster.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007252","count":7},{"id":"GO:0034162","count":6},{"id":"GO:0045410","count":6},{"id":"GO:0090141","count":6},{"id":"GO:0016336","count":6}]},{"hash":"1535095643589325669","title":"Unknown","description":"The terms span cell cycle-related processes (cell cycle, spindle assembly, CDK regulation) and a wide mix of neuronal, developmental, and metabolic functions, with no single shared theme and no edges linking proteins. This lack of cohesion means no reliable label beyond Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0050968","count":1},{"id":"GO:1900383","count":1},{"id":"GO:0051225","count":1},{"id":"GO:0007253","count":1}]},{"hash":"2057851548676455216","title":"Keratinization and Cornification","description":"Most terms point to epidermal differentiation and keratinized skin formation (keratinization, cornification, keratinocyte activation). A few neural glia-related terms are present but do not outweigh the epidermal signal, suggesting the cluster centers on keratinocyte differentiation and skin barrier formation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":2},{"id":"GO:0060020","count":2},{"id":"GO:0072201","count":2},{"id":"GO:0043000","count":2},{"id":"GO:0070268","count":2}]},{"hash":"789364208059781642","title":"ECM adhesion and remodeling","description":"This cluster centers on integrin-mediated signaling, cell\u2013matrix adhesion, and regulation of extracellular matrix assembly, indicating proteins that mediate adhesion to the ECM and remodeling of the matrix. The presence of coagulation, complement activation, and extravasation terms suggests an inflammatory/vascular context where adhesion and ECM remodeling influence vascular permeability and immune cell trafficking, forming a coherent theme around ECM adhesion/remodeling with inflammatory signals.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007229","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0007161","count":6},{"id":"GO:0031104","count":6},{"id":"GO:0001867","count":5}]},{"hash":"1593791803275298866","title":"NF-kappaB\u2013TNF immune signaling","description":"This cluster centers on inflammatory signaling pathways, with strong representation of canonical NF-kappaB activation (activation of NF-kappaB-inducing kinase, I-kappaB phosphorylation), TNF-mediated signaling, and ubiquitination, spanning both innate and adaptive immune responses.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0090073","count":4},{"id":"GO:0002250","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0043123","count":3}]},{"hash":"10689081872493329","title":"Neural crest development and EMT signaling","description":"The top GO terms cluster around neural crest formation, epithelial-to-mesenchymal transition, angiogenesis, and ossification, indicating a developmental program of mesenchymal differentiation and tissue morphogenesis; other terms hint at regulatory signaling and nuclear import, consistent with coordinated regulation during differentiation.","confidence":"High","size":8,"edges":25,"triangles":39,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":8},{"id":"GO:0008284","count":7},{"id":"GO:0007613","count":7},{"id":"GO:0030437","count":7},{"id":"GO:0006607","count":7}]},{"hash":"1306322313032723438","title":"Unknown","description":"The GO terms are diverse, including potassium transport, cytokinesis-related septation, cell polarity, and plant development, with no single coherent functional theme tying all proteins together.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0000920","count":1},{"id":"GO:2000100","count":1},{"id":"GO:0042327","count":1},{"id":"GO:0007118","count":1}]},{"hash":"788500662419025429","title":"Neurocardiac development and metabolism","description":"The top terms indicate developmental processes in brain and heart, along with energy-related metabolism (glucose/glycogen and lipid catabolism). Additional terms (neuron survival, pinocytosis, grooming behavior) point to neural function. Together, these suggest a cluster centered on neurocardiac development linked with metabolic processes, rather than a single narrowly defined function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":3},{"id":"GO:0006006","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1108833078309369144","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":21,"triangles":24,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":5},{"id":"GO:0006096","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0006103","count":3}]},{"hash":"738580283567735087","title":"Acetyl-CoA and Fatty Acid Metabolism","description":"The top GO terms cluster around acetyl-CoA generation from acetate, fatty acid biosynthesis and fatty-acyl-CoA metabolism, and related transport and catabolic processes, suggesting a core theme of lipid and central carbon metabolism. A few terms (like seed germination regulation) are peripheral or context-specific, but the dominant signal is lipid/acetyl-CoA metabolism.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019427","count":7},{"id":"GO:0010124","count":7},{"id":"GO:1902987","count":7},{"id":"GO:0019654","count":7},{"id":"GO:0006633","count":7}]},{"hash":"528750685921626659","title":"Muscle and nerve development","description":"The top GO terms center on muscle-related development (myoblast fusion, heart development, response to muscle activity) and neural components (Schwann cell development, long-term synaptic potentiation, excitatory postsynaptic potential), suggesting a coordinated developmental program linking muscle and nervous system. Additional terms about cell cycle, phosphorylation, and apoptosis regulation are general processes that can accompany development. Overall, the cluster appears to reflect muscle\u2013nerve development and signaling. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007520","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0014850","count":4}]},{"hash":"1064058032710946330","title":"Central carbon metabolism","description":"These proteins cluster around core energy metabolism. GO terms point to glycolysis, pyruvate to acetyl-CoA, the TCA cycle, gluconeogenesis, and amino-acid catabolism feeding into acetyl-CoA, indicating central carbon metabolism and energy production; fatty acid biosynthesis and a sodium transport term suggest related membrane-associated metabolic activities. Overall the theme is central carbon flux rather than a single pathway.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033512","count":6},{"id":"GO:0006096","count":4},{"id":"GO:0006099","count":4},{"id":"GO:0019878","count":4},{"id":"GO:0006552","count":3}]},{"hash":"1378766543635323186","title":"TLR signaling and cytokine production","description":"The top GO terms are dominated by Toll-like receptor signaling (TLR3, TLR9) with downstream MyD88-dependent pathways and cytokine regulation, including positive regulation of IL-6 and interferon-alpha production. While a few terms touch on autophagy and development, the core functionality points to innate immune sensing and cytokine responses driven by TLR signaling, making this label representative and specific.","confidence":"High","size":8,"edges":8,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0034162","count":5},{"id":"GO:0045410","count":5},{"id":"GO:0090141","count":5},{"id":"GO:0042552","count":5},{"id":"GO:0072237","count":5}]},{"hash":"1523664059061509539","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":2},{"id":"GO:0001825","count":1},{"id":"GO:0032869","count":1},{"id":"GO:0031047","count":1},{"id":"GO:1900363","count":1}]},{"hash":"1542186249762666962","title":"Meiosis and Gamete Development","description":"The cluster\u2019s top GO terms are dominated by gametogenesis and meiotic processes, including spermatogenesis, spermatid development, pollen development, embryo sac development, reciprocal meiotic recombination, and double-strand break repair. These collectively point to meiotic DNA processing and gamete formation across species. A few terms like hair cycle or mechanosensory behavior are present but far less represented, so the core signal remains meiosis/gametogenesis.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":2},{"id":"GO:0045071","count":1},{"id":"GO:0006955","count":1},{"id":"GO:0007286","count":1},{"id":"GO:0007638","count":1}]},{"hash":"1011684541261801744","title":"Xenobiotic and Hormone Metabolism","description":"The proteins in this cluster are enriched for a broad set of metabolic processes, including bile acid catabolism, xenobiotic metabolism, catecholamine and thyroid hormone metabolism, flavonoid metabolism, and carbohydrate-related pathways (N-acetylglucosamine; glycosaminoglycan biosynthesis). This pattern points to a module involved in broad processing of diverse small molecules and signaling compounds rather than a single, specific pathway, justifying the label as Xenobiotic and Hormone Metabolism.","confidence":"Medium","size":8,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030573","count":4},{"id":"GO:0006044","count":4},{"id":"GO:0015015","count":4},{"id":"GO:0042403","count":4},{"id":"GO:0030205","count":4}]},{"hash":"409054719832526088","title":"Hormone signaling and stress-response regulation","description":"The cluster is enriched for GO terms involving hormonal signaling (growth hormone secretion, estradiol response) and a stress-related MAPK cascade (stress-activated), plus TGF-beta signaling, suggesting a common theme around modulation of signaling pathways in response to hormonal and stress cues. Supporting terms related to protein stabilization and cell adhesion may reflect ancillary roles in maintaining signaling complexes and cell contacts, but the dominant signal is hormone- and stress-responsive regulation.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060124","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0050821","count":1},{"id":"GO:0007568","count":1}]},{"hash":"1730187894763239983","title":"Angiogenesis and vascular-immune regulation","description":"The top terms cluster around regulation of blood vessel formation (negative regulation of angiogenesis, endothelial morphogenesis, negative regulation of endothelial proliferation) and vascular remodeling, plus components of coagulation and immune activity (immunoglobulin production, plasma cell differentiation). This pattern suggests a coherent theme of vascular development/remodeling coordinated with immune functions. A few unrelated terms (neuron projection, tendon differentiation, respiration) appear but are low in representation and do not define the cluster.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0072378","count":2},{"id":"GO:0010977","count":1},{"id":"GO:0001886","count":1},{"id":"GO:0002377","count":1}]},{"hash":"319899738538280093","title":"Splicing Regulation and mRNA Stability","description":"The cluster is dominated by GO terms related to post-transcriptional control, especially regulation of alternative mRNA splicing via the spliceosome, and negative regulation of splicing, plus mRNA stabilization and regulatory ncRNA-mediated gene silencing. Some developmental terms appear but likely reflect broader roles of RNA processing in development rather than a distinct pathway. Overall, the proteins seem tied to RNA processing and post-transcriptional regulation rather than a single metabolic or signaling function.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":3},{"id":"GO:0001825","count":2},{"id":"GO:0003283","count":2},{"id":"GO:0031047","count":2},{"id":"GO:1900363","count":2}]},{"hash":"1361233597250157661","title":"Mitochondrial transporters and energy metabolism","description":"This cluster is driven by multiple mitochondrial transmembrane transport terms (citrate, L-ornithine, thiosulfate, ATP), membrane potential regulation, and heme transport, indicating proteins involved in substrate movement and energy balance across mitochondria. Some terms about cellular responses to insulin and amino acid starvation reflect metabolic signaling connected to mitochondrial function, reinforcing the theme of mitochondria-centric transport and energy regulation.","confidence":"High","size":8,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":2},{"id":"GO:0015886","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0000066","count":2},{"id":"GO:0097421","count":2}]},{"hash":"716433296240291535","title":"Adhesion signaling and cytoskeletal organization","description":"The top GO terms point to receptor-mediated signaling and cell adhesion (e.g., Fc-epsilon receptor signaling, receptor clustering, and cell-matrix adhesion) together with cytoskeletal and ciliogenesis processes (microtubule organization, mitotic spindle organization, non-motile cilium assembly), suggesting a theme of signaling at the cell surface coupled to structural remodeling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":1},{"id":"GO:2001199","count":1},{"id":"GO:0031122","count":1},{"id":"GO:0007052","count":1},{"id":"GO:1905515","count":1}]},{"hash":"1356509811072038971","title":"Integrin-mediated adhesion and immune signaling","description":"This cluster centers on integrin signaling and cell\u2013cell adhesion, with components related to immune cell activation and cell migration (T cell activation, integrin signaling, substrate-dependent migration, heterotypic adhesion). While some terms like stamen formation, proteasome assembly, and obsolete ADP-ribosylation appear unrelated, the dominant themes point to adhesion-mediated signaling and leukocyte activity.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0034113","count":1},{"id":"GO:0007229","count":1},{"id":"GO:0002291","count":1},{"id":"GO:0007596","count":1}]},{"hash":"1321545670932035810","title":"Lipid mediator biosynthesis and lipid homeostasis","description":"The top GO terms cluster around lipid metabolism and eicosanoid biosynthesis\u2014hepoxilin, leukotriene A4, and lipoxin biosynthetic processes\u2014along with cholesterol and phospholipid homeostasis. This points to a shared role in lipid signaling and membrane lipid turnover, with additional links to macrophage-related processes and immune regulation, suggesting the proteins participate in lipid-mediated signaling rather than a single, narrow function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042632","count":1},{"id":"GO:0021510","count":1},{"id":"GO:0051122","count":1},{"id":"GO:1901074","count":1},{"id":"GO:1901751","count":1}]},{"hash":"212241677497225995","title":"Myelin lipid biosynthesis and myelination","description":"The two strongest terms are GO:0042552 myelination and GO:0006682 galactosylceramide biosynthetic process, which together point to myelin formation and its lipid components (galactosylceramide). While other terms touch on development or transcription and include some obsolete entries, they do not define a coherent alternative function for the cluster. Thus, the most representative theme is myelin lipid biosynthesis and myelination.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0006682","count":2},{"id":"GO:0060325","count":1},{"id":"GO:0014834","count":1},{"id":"GO:0006351","count":1}]},{"hash":"1003400966896507065","title":"Cerebellar development and MAPK signaling regulators","description":"The cluster is dominated by terms related to neural development in the cerebellum (cerebellar cortex formation, Bergmann glial cell differentiation, axon regeneration) and regulation of MAPK/ERK signaling (negative regulation of ERK cascade). Additional signals include insulin signaling, suggesting metabolic\u2013neural signaling interplay; some immune-related terms are present but less central. This supports a label focused on cerebellar development and MAPK pathway regulation.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":7},{"id":"GO:0000200","count":7},{"id":"GO:0050860","count":7},{"id":"GO:0048679","count":6},{"id":"GO:0021697","count":6}]},{"hash":"1645750121016161934","title":"Embryonic organogenesis","description":"The top GO terms revolve around morphogenesis and organ development during embryogenesis across multiple tissues (eye, heart, cranial skeleton, habenula, prostate, and gonads), indicating a cohesive theme of embryonic organ formation rather than a single tissue-specific function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048048","count":5},{"id":"GO:0060441","count":4},{"id":"GO:2000288","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0048701","count":4}]},{"hash":"352876111877871018","title":"Photosynthesis-Related Energy Transduction","description":"Dominated by photosynthesis and photoprotection terms (photosynthesis and nonphotochemical quenching) and proton transmembrane transport, this cluster most plausibly groups proteins involved in light-driven energy capture and energy transduction; the aromatic compound catabolic terms seem secondary, reflecting broader metabolic capabilities rather than a single unifying function.","confidence":"Medium","size":8,"edges":11,"triangles":6,"max_degree":5,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0046381","count":3},{"id":"GO:1902600","count":3},{"id":"GO:0046232","count":3},{"id":"GO:0010196","count":3}]},{"hash":"1182636726882389703","title":"Flavonoid glycoside biosynthesis and lignin metabolism","description":"The top GO terms cluster around biosynthesis of kaempferol, quercetin, and cyanidin glucosides and lignin metabolism, pointing to the phenylpropanoid pathway in plants. A few unrelated terms (e.g., paranode localization) may reflect annotation noise, but the central theme remains plant secondary metabolism.","confidence":"Medium","size":8,"edges":12,"triangles":8,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0033330","count":7},{"id":"GO:0033303","count":7},{"id":"GO:0009808","count":7},{"id":"GO:0002175","count":7},{"id":"GO:0033485","count":7}]},{"hash":"834417079951532160","title":"Innate Immune Signaling and Signal Transduction","description":"Most prominent terms are innate immune and antiviral defense (defense response to virus, innate immune response, cellular response to type I interferon), plus general signal transduction terms (regulation of GPCR signaling, steroid hormone receptor complex assembly) and some cell cycle-related terms (mitotic cell cycle, mitotic metaphase/anaphase transition). The common thread is a set of proteins involved in signaling and immune responses, with incidental links to mitosis, suggesting a broad signaling/immune cluster rather than a single specific process.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045842","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0009736","count":3},{"id":"GO:2001162","count":2}]},{"hash":"2043399184266022471","title":"Vesicle Trafficking and Autophagy","description":"The main GO terms point to intracellular transport within the secretory pathway (ER to Golgi, early endosome to Golgi) and autophagy, with additional signals for GTPase activity regulation that drive membrane trafficking. While there are some development- or immune-related terms in the list, the strongest shared theme ties to vesicle movement and autophagic processes, suggesting a functional cluster in membrane trafficking and degradation pathways.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034498","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0006914","count":1},{"id":"GO:0001501","count":1},{"id":"GO:0045212","count":1}]},{"hash":"607607563543318927","title":"Actin Dynamics in Morphogenesis","description":"Based on the strong representation of lamellipodium assembly and actin filament depolymerization, the cluster centers on actin cytoskeleton remodeling involved in cell shape changes. The accompanying terms on integrin-mediated signaling and diverse morphogenesis (haltere, plant ovule, metanephric kidney) point to actin-driven developmental processes, with a transcription-related term likely incidental. Confidence: Medium","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0048735","count":3},{"id":"GO:0042789","count":3},{"id":"GO:0090334","count":3},{"id":"GO:0008588","count":3}]},{"hash":"1938280647445827391","title":"Unknown","description":"The top GO terms span disparate processes\u2014from cell wall organization and glycosylation to mRNA stability, renal water transport, aging, cell cycle regulation, redox balance, cAMP signaling, DNA metabolism, and skin (corneocyte) development. There is no clear shared function or pathway that ties all proteins together, and the absence of edges reinforces the lack of a cohesive theme.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071555","count":3},{"id":"GO:0016266","count":3},{"id":"GO:0043488","count":3},{"id":"GO:2001153","count":3},{"id":"GO:0007568","count":3}]},{"hash":"51260505563287614","title":"Adaptive and innate immune activation with antigen presentation","description":"These proteins map to both adaptive and innate immune processes, including adaptive immune response, cytokine production, B cell activation, immunoglobulin production, T cell costimulation, and antigen processing and presentation via MHC class II. The inclusion of a GO term for maintenance of gastrointestinal epithelium suggests a mucosal immune context. Taken together, the cluster centers on immune signaling and antigen presentation at the mucosal interface.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0002374","count":2},{"id":"GO:0050871","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0071224","count":2}]},{"hash":"1037296374206458416","title":"Mitotic chromosome segregation and cell-cycle control","description":"The top GO terms are dominated by mitosis-related processes: mitotic cell cycle, mitotic sister chromatid segregation and cohesion, APC/C-dependent catabolic process, and regulation of meiotic nuclear division, indicating a core role in chromosome segregation and cell-cycle regulation. Other terms touching on nuclear transport and cytoskeletal dynamics appear as broader contextual processes but do not outweigh the mitotic theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035721","count":3},{"id":"GO:0030042","count":3},{"id":"GO:0031081","count":3},{"id":"GO:0031145","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1676684237062735344","title":"Unknown","description":"This set includes both neuronal functions (substantia nigra development and excitatory postsynaptic potential) and various immune/cytoskeletal processes (cellular response to xenobiotic stimulus, NF-kappaB regulation, actin cytoskeleton reorganization, nuclear migration, wound healing, mast cell degranulation, macrophage differentiation), with no clear single theme tying all terms together.","confidence":"","size":8,"edges":5,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021762","count":4},{"id":"GO:0035690","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0043124","count":3}]},{"hash":"539888216546713335","title":"Unknown","description":"The top GO terms include immune signaling (chemokine production regulation, B cell homeostasis, IL-23 production regulation) alongside neural, sensory, and heart/vascular development terms, indicating a heterogeneous set with no single unifying function. ","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071651","count":5},{"id":"GO:2000340","count":5},{"id":"GO:0060313","count":5},{"id":"GO:0097194","count":4},{"id":"GO:0001782","count":4}]},{"hash":"1587263489898104235","title":"Unknown","description":"The top GO terms span cocaine response, apoptosis and death signaling, development in thymus and hippocampus, skin differentiation, and miscellaneous transport processes, with no unifying biological function. The lack of edges/clear cohesion suggests no single cohesive theme for the cluster.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":4},{"id":"GO:0042997","count":3},{"id":"GO:0030216","count":3},{"id":"GO:0097194","count":3},{"id":"GO:0048538","count":3}]},{"hash":"2072889093708381404","title":"Ubiquitination and NF-kappaB Signaling","description":"The Top Terms are dominated by ubiquitin-dependent processes (protein degradation, various ubiquitin linkages such as K6 and K63, and autoubiquitination) and by regulation of NF-kappaB signaling (including TNF-mediated pathways). Vitamin D response is less central, but overall the cluster appears to center on post-translational ubiquitin modifications and their impact on NF-kappaB\u2013driven signaling, justifying a label focused on ubiquitination with NF-kappaB regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0036205","count":5},{"id":"GO:0097039","count":5},{"id":"GO:0060546","count":5},{"id":"GO:1903265","count":5}]},{"hash":"1798943376581059458","title":"Methylation-Driven Biosynthesis Enzymes","description":"These proteins show a strong enrichment for methylation-related GO terms (RNA methylation, N-terminal peptidyl-serine methylation, guanine-N7 methylation, histone methylation) alongside a variety of biosynthetic processes (phosphatidylcholine, ubiquinone, sterol, juvenile hormone, selenium compounds). The common thread appears to be methylation chemistry linked to diverse biosynthetic pathways, suggesting a cluster of methyltransferases or methylation-associated enzymes involved in multiple biosynthetic steps.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001887","count":2},{"id":"GO:0006656","count":2},{"id":"GO:0006744","count":2},{"id":"GO:0031167","count":2},{"id":"GO:0035573","count":2}]},{"hash":"370599382213307925","title":"Ubiquitin-Driven Mitosis and Chromatin Regulation","description":"This cluster centers on ubiquitin-mediated proteolysis and chromatin regulation, with SCF-dependent proteasomal degradation, free ubiquitin chains, and histone ubiquitination. It also includes cell cycle and chromosome segregation processes (G2/M transition, segregation) and subtelomeric heterochromatin formation, plus DNA repair signals (nucleotide-excision repair). Together, these terms suggest a cohesive role for ubiquitin signaling coordinating mitosis, chromatin dynamics, and genome maintenance.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0016032","count":8},{"id":"GO:0070911","count":8},{"id":"GO:0010458","count":8},{"id":"GO:0007059","count":8},{"id":"GO:0000086","count":8}]},{"hash":"167221828785686094","title":"Ribosome biogenesis and cell cycle","description":"These proteins cluster around ribosome assembly and biogenesis (ribosome biogenesis, ribosomal subunit biogenesis, ribosomal subunit export) and cell division/cell cycle processes (cell division, cell cycle, cell septum assembly). The presence of tRNA modification also ties to translation machinery, supporting a theme of coordinating ribosome production with cell proliferation. Confidence: High","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006400","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0042254","count":2},{"id":"GO:1903833","count":2}]},{"hash":"754227096509347570","title":"Mitochondrial lipid metabolism and signaling","description":"The terms strongly center on mitochondria and lipid biology (cardiolipin metabolism, positive regulation of mitochondrial DNA replication, lipid localization), with an additional hint of signaling via PKC. A few terms relate to glycosylation and excretion but seem peripheral, so the core theme is mitochondrial lipid metabolism and associated signaling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":3},{"id":"GO:2000049","count":2},{"id":"GO:0070584","count":2},{"id":"GO:0007588","count":2},{"id":"GO:0010876","count":2}]},{"hash":"1998409090958484881","title":"Synaptic protein localization","description":"The dominant GO terms are receptor localization to synapse and protein localization to synapse, indicating these proteins are primarily involved in targeting to synaptic compartments. While there are a few immune signaling and cytoskeletal terms present, they are much less represented and do not define the cluster. Thus, synaptic localization is the most representative theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097120","count":2},{"id":"GO:0035418","count":2},{"id":"GO:0006409","count":1},{"id":"GO:0043124","count":1},{"id":"GO:0051638","count":1}]},{"hash":"1490832142657714067","title":"Neuronal signaling and sensory processing","description":"This cluster centers on neurotransmitter receptor signaling and synaptic transmission (acetylcholine, GABA, glycine), regulation of nerve impulse transmission, and processes tied to sensory systems (vestibulocochlear and optic nerves) and sensory processing, including dopamine-related modulation and long-term potentiation. The convergence of these GO terms points to a cohesive role in neural communication and the development/organization of sensory pathways, justifying a concise label focused on neural signaling and sensory function.","confidence":"High","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0095500","count":8},{"id":"GO:0002087","count":8},{"id":"GO:0051970","count":8},{"id":"GO:0097112","count":8},{"id":"GO:1900273","count":8}]},{"hash":"1842114462316457496","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043124","count":2},{"id":"GO:0032760","count":2},{"id":"GO:0006382","count":1},{"id":"GO:1901639","count":1},{"id":"GO:1901911","count":1}]},{"hash":"1932476418896493803","title":"Neural development and signaling","description":"Top terms are dominated by neural-related processes: CNS development, innervation, rhodopsin-mediated signaling in photoreceptors, and glial cell-derived neurotrophic factor receptor signaling. While some terms pertain to non-neural tissues (kidney basement membrane development, chondrocyte development, colon epithelial migration, esophagus smooth muscle contraction, prostatic bud regulation), the strongest and most cohesive theme centers on neuronal development and signaling, supporting this label.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016058","count":1},{"id":"GO:0003094","count":1},{"id":"GO:0014846","count":1},{"id":"GO:0060384","count":1},{"id":"GO:0061580","count":1}]},{"hash":"1376939370157123460","title":"Embryogenesis and Tissue Morphogenesis","description":"Dominant GO terms point to embryonic development and tissue morphogenesis, including endocrine system development, cartilage morphogenesis, EMT in endocardial cushion formation, placental differentiation, left-right pattern formation, and pancreatic cell development, with accompanying intracellular signal transduction; a few terms (pollen tube guidance) appear plant-specific outliers.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0060806","count":4}]},{"hash":"507190510597784861","title":"Developmental Patterning and Organogenesis","description":"The top terms show a clear emphasis on development and patterning (left/right pattern formation, organ development like pancreas and palate), which suggests a cohesive cluster of developmental processes and organogenesis. Other terms related to splicing and transcription regulation appear as general cellular processes that accompany development but do not outweigh the developmental theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":8},{"id":"GO:0042542","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0060021","count":8},{"id":"GO:0035270","count":8}]},{"hash":"715559933958636452","title":"Neural crest migration and axon guidance","description":"This cluster is dominated by neural development signals, with terms like ventral trunk neural crest cell migration, commissural neuron axon guidance, and axon extension/guidance. While there are additional terms related to angiogenesis and signaling pathways (e.g., hedgehog Smoothened and receptor tyrosine kinase activity), the strongest and most consistent theme is neural crest migration and axon guidance, which justifies the label. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0048842","count":6},{"id":"GO:0045880","count":6},{"id":"GO:0002042","count":6},{"id":"GO:0048846","count":6}]},{"hash":"1863434187780972432","title":"Unknown","description":"The GO terms span hormone signaling, immune signaling, and diverse developmental/neural processes with no clear shared function linking them, so a cohesive cluster theme cannot be identified.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042699","count":7},{"id":"GO:1904588","count":7},{"id":"GO:0034162","count":7},{"id":"GO:0045410","count":7},{"id":"GO:0090141","count":7}]},{"hash":"652980135884547087","title":"Mitochondrial mitophagy and nutrient-starvation response","description":"Top GO terms point to mitochondrial protein catabolic process and mitophagy, together with cellular responses to glucose and amino acid starvation, indicating a cluster focused on mitochondrial quality control under nutrient stress. A neuron projection term is present but less aligned with the core theme. Overall, the label captures the predominant function of the cluster.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035694","count":1},{"id":"GO:0035695","count":1},{"id":"GO:0033554","count":1},{"id":"GO:0071232","count":1},{"id":"GO:0042149","count":1}]},{"hash":"1376859625941956859","title":"Innate immune signaling and NF-kappaB/TNF regulation","description":"The top GO terms cluster around innate immunity and inflammatory signaling, including innate immune response, regulation of NF-kappaB transcription factor activity, JNK cascade, and TNF-mediated signaling. There is also an autoubiquitination term and T cell receptor signaling, all suggesting proteins involved in immune signaling pathways rather than a single enzyme or process. Even though there are no edges among the proteins, the shared functions point to a coherent theme of immune and inflammatory regulation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:0046328","count":5},{"id":"GO:0045087","count":5},{"id":"GO:1901253","count":5},{"id":"GO:1903265","count":5}]},{"hash":"2181694485570032118","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006458","count":6},{"id":"GO:0045454","count":6},{"id":"GO:0046825","count":6},{"id":"GO:0034975","count":6},{"id":"GO:1901621","count":6}]},{"hash":"801726349558100638","title":"Adhesion and Immune Signaling with Protein Turnover","description":"The terms cluster around cell adhesion (heterotypic adhesion) and integrin signaling, with immune activation (T cell activation via TCR) and migration/coagulation processes, plus proteostasis (ubiquitin-dependent degradation and proteasome assembly). A plant-specific term (stamen formation) appears irrelevant to the core theme. This suggests a cohesive theme of adhesion-mediated signaling intertwined with immune/coagulation responses and regulated protein turnover.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0034113","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0002291","count":2},{"id":"GO:0007596","count":2},{"id":"GO:1905050","count":2}]},{"hash":"653376063194859699","title":"Clathrin-mediated vesicle trafficking","description":"The top GO terms cluster around intracellular transport, synaptic vesicle coating, and clathrin-dependent endocytosis, pointing to roles in vesicle formation and recycling via clathrin pathways. While a few terms touch translation or neuronal differentiation, the strongest signal is vesicle trafficking, especially clathrin-mediated endocytosis.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":2},{"id":"GO:0016183","count":2},{"id":"GO:0072583","count":2},{"id":"GO:0070196","count":1},{"id":"GO:0071033","count":1}]},{"hash":"1386062547183870582","title":"Kidney development and immune signaling","description":"Most terms point to nephron and kidney development (metanephric/proximal tubule development, mesonephric duct development, related morphogenesis). A subset references immune-related processes (phagocytosis recognition, leukocyte tethering/rolling, basophil activation, C-type lectin receptor signaling, response to fungal origin). The dominant theme is kidney development with some immune signaling annotations, suggesting a cluster of nephrogenesis genes with incidental immune-function associations.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0072177","count":1},{"id":"GO:0006910","count":1},{"id":"GO:0072218","count":1},{"id":"GO:0050901","count":1}]},{"hash":"2150112858788996896","title":"Wnt and HGF signaling with calcium flux","description":"This cluster centers on signaling pathways, notably Wnt signaling and hepatocyte growth factor receptor signaling, with accompanying calcium mobilization and GPCR-PLC\u2013related signaling. These terms suggest a cohesive theme of growth-factor\u2013 and calcium-dependent signal transduction influencing cell migration and development, despite some peripheral terms like coagulation or IL-6 regulation. Therefore, a concise label reflecting growth-factor and calcium signaling best represents the group.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007223","count":5},{"id":"GO:0048012","count":5},{"id":"GO:0051281","count":5},{"id":"GO:0014909","count":5},{"id":"GO:0014068","count":5}]},{"hash":"1292611817293152378","title":"Fatty acid synthesis and transport","description":"The top GO terms converge on lipid metabolism, notably medium-chain fatty-acyl-CoA metabolic process, fatty acid biosynthetic process, and import/uptake of long-chain fatty acids, indicating a cluster of proteins involved in fatty acid production and lipid import. Some ancillary terms (e.g., oxidative stress, obsolete biosynthesis terms) appear as noise but do not override the lipid-focused signal. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0036112","count":3},{"id":"GO:0042542","count":2},{"id":"GO:0019427","count":2},{"id":"GO:0010124","count":2},{"id":"GO:1902987","count":2}]},{"hash":"2029400815574875969","title":"Translation control and RNA granule dynamics","description":"These proteins cluster around post-transcriptional regulation: mRNA processing bodies, translational initiation control, stress granule assembly, and circadian regulation of translation. Developmental terms (eye photoreceptor and oocyte differentiation) likely reflect context-specific translational control during differentiation, while mitotic spindle assembly suggests coordination with cell division. Overall, the theme is RNA metabolism and translation control via granules and timing mechanisms.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0010603","count":2},{"id":"GO:0045947","count":2},{"id":"GO:0051823","count":2},{"id":"GO:0009994","count":2}]},{"hash":"2289489946062964039","title":"Unknown","description":"The top terms cover a highly diverse mix of processes (splicing, DNA replication initiation, chromatin-related telomere regulation, neuronal vesicle transport, eggshell gene amplification, gas vesicle and bacterial chlorophyll-related processes, and gamete generation). This lack of a single coherent functional theme across the cluster suggests there is no clear common function tying these proteins together, so a specific label is not warranted. ","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":2},{"id":"GO:0030174","count":1},{"id":"GO:1990048","count":1},{"id":"GO:1902975","count":1},{"id":"GO:0006348","count":1}]},{"hash":"1270736524124458965","title":"Unknown","description":"These terms span hormone signaling (FSH/LH), immune signaling (TLR9, interferon, IL-6), GPCR signaling, and unrelated processes like mitochondrial fission, myelination, and kidney development. No single pathway or function binds all proteins, so a cohesive label is not supported.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042699","count":6},{"id":"GO:1904588","count":6},{"id":"GO:0034162","count":6},{"id":"GO:0045410","count":6},{"id":"GO:0090141","count":6}]},{"hash":"1765096874562528737","title":"NF-\u03baB\u2013regulated innate immunity and autophagy","description":"The top GO terms point to innate immune response, defense against virus, autophagy, and regulation of NF-\u03baB signaling, plus negative regulation of T cell and germinal center processes. This pattern suggests a cohesive theme of innate immune signaling with autophagy as a regulatory node, modulating antiviral responses and balancing adaptive immunity.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0060546","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0048536","count":5},{"id":"GO:0043123","count":5}]},{"hash":"1988359982151571956","title":"Ribosome biogenesis and translation initiation","description":"The proteins cluster around ribosome assembly and multiple steps of translation initiation, including preinitiation complex formation and viral IRES-driven initiation, indicating a core link to the protein synthesis machinery. Some transcription/splicing terms appear, but translation-related terms dominate, justifying a focus on ribosome biogenesis and initiation.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0048025","count":2},{"id":"GO:0007338","count":2}]},{"hash":"933733305763484187","title":"Ubiquitin-dependent proteolysis with immune regulation","description":"This cluster is dominated by ubiquitin-dependent protein catabolic process (5 annotations) and includes several immune-related terms (negative regulation of IgE isotype switching, positive regulation of pro-T cell differentiation, type 2 immune response, and negative regulation of mast cell cytokine production), suggesting a link between protein turnover and immune signaling. Some terms such as circadian rhythm, sarcomere organization, and gravitropism appear less related and may reflect broader or cross-species annotations, but do not outweigh the core proteolysis/immune theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0048294","count":3},{"id":"GO:2000176","count":3},{"id":"GO:0042092","count":3},{"id":"GO:0009958","count":3}]},{"hash":"1719724515494909782","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032925","count":1},{"id":"GO:1901710","count":1},{"id":"GO:0009749","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0006463","count":1}]},{"hash":"1366971015972933175","title":"Cardiac electrical activity and calcium signaling","description":"The cluster is enriched for GO terms tied to cardiac electrical activity and calcium handling, including regulation of SA node and atrial cardiac muscle cell action potentials and regulation of calcium release to control contraction. The presence of excitatory postsynaptic potential and synaptic vesicle endocytosis terms suggests a broader theme of electrical signaling, bridging cardiac and neural signaling. Some terms like mitotic processes and ubiquitination appear as potential annotation noise or multi-functional proteins, and an ossification term is an outlier. Overall, the dominant pattern points to cardiac electrical signaling with calcium regulation, with some cross-talk to neuronal signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098907","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0010881","count":3},{"id":"GO:1900242","count":3}]},{"hash":"1187341888085928351","title":"Unknown","description":"The GO terms span membrane organization, immune signaling, and nervous system traits with no clear shared pathway, making a single representative function unlikely.","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070941","count":1},{"id":"GO:0042552","count":1},{"id":"GO:0002337","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0035208","count":1}]},{"hash":"2278440309972537553","title":"Vascular-immune signaling cluster","description":"The terms strongly point to signaling pathways that regulate vascular functions (GPCR signaling, vasopressin/blood pressure) and immune processes (IL-1\u03b2 production, dendritic cell differentiation), with Rho-mediated cytoskeletal signaling and metabolic context (electron transport) as supporting aspects. This suggests a cohesive theme of signaling integration between vascular regulation and immune responses, despite some terms touching metabolic or sensory maintenance.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0035025","count":7},{"id":"GO:0045494","count":6}]},{"hash":"787586022542380244","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009788","count":1},{"id":"GO:0032434","count":1},{"id":"GO:0006446","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0001731","count":1}]},{"hash":"610774107763741221","title":"COPI-Mediated ER-Golgi Vesicle Trafficking","description":"The dominant GO terms point to COPI-coated vesicle budding, COPI coating of Golgi vesicles, ER-to-Golgi transport, and Golgi ribbon formation, all of which reflect COPI-mediated trafficking and maintenance of ER-Golgi compartments. A few terms appear unrelated (developmental and behavioral), suggesting incidental annotations, but the core of the cluster is the vesicle trafficking machinery governing protein exit from the ER and Golgi trafficking.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1902003","count":1},{"id":"GO:0035964","count":1},{"id":"GO:0048205","count":1},{"id":"GO:0090161","count":1},{"id":"GO:0002121","count":1}]},{"hash":"328173507277634879","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0006364","count":2},{"id":"GO:1903026","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0032298","count":1}]},{"hash":"415268784908555015","title":"ECM adhesion and collagen signaling in skin/cartilage","description":"The cluster is dominated by GO terms for cell adhesion and ECM signaling (cell adhesion, integrin biosynthesis, collagen-activated signaling) and tissue development (skin morphogenesis, skin development, cartilage development). The overlap of integrin/collagen pathways with ECM remodeling aligns with a cohesive module governing skin and cartilage formation, with positive regulation of cytoskeletal and Rho signaling supporting adhesion dynamics. The aldosterone-related term appears peripheral and does not change the core ECM/adhesion theme. Therefore, ECM adhesion and collagen signaling best captures the cluster\u2019s function.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0035023","count":2},{"id":"GO:2000860","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0033034","count":2}]},{"hash":"1781083370313351834","title":"Spliceosome and RNA processing","description":"The top GO terms are strongly centered on RNA splicing and processing, including spliceosomal snRNP assembly and mRNA splicing via the spliceosome, as well as related RNA maturation steps (tRNA processing, rRNA maturation) and mRNA decay/processing (P-body assembly, deadenylation-dependent decapping). This combination points to a coherent group of proteins involved in splicing and broader RNA maturation/processing.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":7},{"id":"GO:0000290","count":7},{"id":"GO:0000387","count":7},{"id":"GO:0033962","count":7},{"id":"GO:0070317","count":7}]},{"hash":"1103379890705719951","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0061158","count":4},{"id":"GO:1902187","count":4},{"id":"GO:0018032","count":4},{"id":"GO:0007014","count":4},{"id":"GO:0001519","count":4}]},{"hash":"523811713093300317","title":"Calcium-regulated vesicle trafficking and endocytosis","description":"This cluster centers on GO terms linking calcium signaling to vesicle trafficking and endocytosis, including positive regulation of voltage-gated calcium channels, release of sequestered calcium, endocytic recycling, endocytosis, and Golgi-to-lysosome transport, which together suggest a set of proteins coordinating calcium-dependent vesicle cycling and synaptic trafficking. Some terms about bud site selection may be incidental, but the dominant theme is calcium-influenced vesicle movement and recycling in neurons and related pathways.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901387","count":3},{"id":"GO:2001137","count":3},{"id":"GO:0051281","count":2},{"id":"GO:0048168","count":2},{"id":"GO:0007121","count":2}]},{"hash":"1250471151543107673","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006310","count":3}]},{"hash":"1752709887262618959","title":"Broad Development and Differentiation Across Tissues","description":"The GO terms show differentiation and development across many tissues (melanocyte, neural crest/cardiac, vestibular system, endocrine pancreas, stomach neuroendocrine cells, osteoblasts, myelination). Most terms denote developmental processes or regulation of differentiation, with no single organ-specific pattern. This suggests a cluster of proteins involved in general development and cell fate decisions rather than a specific pathway, hence a broad label.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030318","count":7},{"id":"GO:0003253","count":7},{"id":"GO:0021750","count":7},{"id":"GO:0003062","count":7},{"id":"GO:0010374","count":7}]},{"hash":"1001124127559317550","title":"Small-molecule metabolism and copper response","description":"The top GO terms point to metabolism of simple metabolites and related pathways (fructose, D-xylulose-5-phosphate, fatty acids, retinol/retinoic acid, aldehydes) along with oxidation-reduction and a notable copper ion response, suggesting a cluster centered on general small-molecule metabolism with metal stress responsiveness.","confidence":"Medium","size":7,"edges":12,"triangles":7,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0046370","count":3},{"id":"GO:0042573","count":3},{"id":"GO:0033859","count":3},{"id":"GO:0019518","count":3}]},{"hash":"1543162406627625533","title":"Hindbrain development and brain segmentation","description":"This cluster is driven by terms like rhombomere 4 development, rhombomere 5 development, brain segmentation, and embryonic skeletal system development, all pointing to embryonic neural patterning and hindbrain morphogenesis. The presence of lamellipodium assembly supports cell migration during neurulation, and transcriptional regulation terms align with developmental gene control. A valine catabolic process term appears as a minor outlier, but does not define the group.","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006574","count":2},{"id":"GO:0007501","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0021570","count":2}]},{"hash":"2063510944245989708","title":"Gonadal development and steroid hormone biosynthesis","description":"The dominant GO terms point to reproductive system development (uterus and female gonad) and steroid hormone production (testosterone, androgen, aldosterone), suggesting a cohesive theme of gonadal development coupled with endocrine hormone biosynthesis; a few other terms appear peripheral and do not undermine this core pattern.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":5},{"id":"GO:0008585","count":5},{"id":"GO:0048565","count":5},{"id":"GO:0061370","count":4},{"id":"GO:0008209","count":4}]},{"hash":"1709185910935586388","title":"Unknown","description":"The GO terms are highly diverse, spanning ubiquitination, pain perception, synaptic plasticity, spindle assembly, NF-kappaB regulation, telomere maintenance, brown fat differentiation, heart morphogenesis, and salicylic acid signaling, with no single clear shared function linking the proteins.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016567","count":6},{"id":"GO:0050968","count":5},{"id":"GO:1900383","count":5},{"id":"GO:0051225","count":5},{"id":"GO:0007253","count":5}]},{"hash":"1573086946234977171","title":"Neural development and neurite outgrowth","description":"Dominated by nervous system\u2013related terms (nervous system development, dendrite development, axonogenesis), with GTPase activity regulation suggesting cytoskeletal remodeling for neurite outgrowth; a few terms related to embryonic cleavage or mitosis are likely incidental to development but do not define the cluster\u2019s main theme.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0060385","count":2},{"id":"GO:0040016","count":1},{"id":"GO:1900087","count":1}]},{"hash":"2055073496451301468","title":"Aromatic compound and lipid catabolism","description":"The cluster is dominated by catabolic pathways across multiple substrate types: aromatic compound degradation (3-phenylpropionate, beta-ketoadipate), lipid breakdown (triglyceride catabolic process), and xenobiotic/aromatic compound detoxification (1,2-dichloroethane catabolic process), with supporting signals of detox responses (response to toxic substance) and hormone turnover (juvenile hormone catabolic process). This points to a shared function in broad catabolic metabolism and detoxification across substrates.","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019380","count":6},{"id":"GO:0042952","count":5},{"id":"GO:0097755","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0009086","count":5}]},{"hash":"841033610699883209","title":"Embryonic neural-muscular-heart development proteins","description":"The GO terms cluster around broad embryonic development with emphasis on skeletal muscle, heart, cranial skeleton morphogenesis, neuron migration, synapse assembly and axon guidance, plus related processes like cell-matrix adhesion and visual perception, suggesting proteins involved in morphogenesis across nervous, muscular, and cardiac tissues.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0001764","count":2}]},{"hash":"1120854020980926036","title":"Skeletal muscle development and sarcomere organization","description":"Based on the top GO terms, the cluster is strongly enriched for skeletal muscle processes: sarcomere organization, skeletal muscle cell differentiation, and skeletal muscle tissue development, indicating a muscle differentiation/sarcomere function cluster. While there are outliers such as nervous system development and renal morphogenesis, the dominant signal points to muscle-related organization and development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0072156","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0035914","count":2}]},{"hash":"1802448901782503170","title":"Neural development and synapse formation","description":"The top GO terms center on neural development processes: lateral motor column neuron migration, regulation of neural retina development, and synapse assembly, alongside cell-cell junction organization, all pointing to neural development and synaptic connectivity. Some terms (antibiotic biosynthetic process, viral process, platelet aggregation, fibrinogen regulation) appear less cohesive with neural development and may reflect annotation noise or multifunctional proteins, but the neural-related terms form a coherent core theme. Overall, the cluster likely represents proteins involved in neural development and synapse formation.","confidence":"Medium","size":7,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0045216","count":3},{"id":"GO:0097477","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0070527","count":3}]},{"hash":"2245517499507866024","title":"Unknown","description":"The top GO terms span several unrelated processes, including dephosphorylation, amino acid biosynthesis, calcium homeostasis, metal ion transport, lipopolysaccharide biosynthesis, hormonal response, and epoxygenase P450 metabolism. There is no single cohesive function tying these proteins together, suggesting a mixed or unclear functional theme.","confidence":"","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0016311","count":5},{"id":"GO:0006564","count":5},{"id":"GO:0006874","count":4},{"id":"GO:0071577","count":4},{"id":"GO:0097755","count":4}]},{"hash":"1274949455772157913","title":"Diverse Metabolic Biosynthesis and Copper Response","description":"The proteins are linked to a variety of biosynthetic and metabolic processes (fructose, fatty acids, retinol/retinoic acid, pentose phosphate) and also to a copper ion response, indicating a broad metabolic cluster with metal stress handling rather than a single pathway.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0046370","count":5},{"id":"GO:0042572","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0042573","count":4},{"id":"GO:0033859","count":4}]},{"hash":"1156428671667323130","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0009432","count":3},{"id":"GO:0071035","count":3},{"id":"GO:0000398","count":3}]},{"hash":"1661899150835091965","title":"Neuronal Axon Guidance and Synapse Assembly","description":"The top GO terms indicate a neural development focus: retinal ganglion cell axon guidance, localization to the paranode region of axons, and positive regulation of synapse assembly, complemented by signaling pathways (PI3K/AKT and TGF-\u03b2 receptor signaling) that influence growth and adhesion. While other terms touch endocrine, kidney, and endothelial processes, the strongest cluster centers on axon guidance, paranodal localization, and synapse organization, suggesting a neural connectivity theme for the group.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0051965","count":3},{"id":"GO:2001027","count":3},{"id":"GO:0048661","count":2}]},{"hash":"1110355830675325466","title":"Unknown","description":"The top GO terms span stress response (hydrogen peroxide), immune signaling (TNF production, germinal center formation), development (imaginal disc-derived leg morphogenesis), RNA stability, renal water transport, and a fungal cell wall biosynthetic process, with no single cohesive function linking the proteins and no edges connecting them. This lack of a shared biological theme across the cluster supports an Unknown label.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":2},{"id":"GO:0032760","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0007480","count":1},{"id":"GO:0043488","count":1}]},{"hash":"2072685713913834005","title":"Wnt Signaling in Development and Morphogenesis","description":"The proteins cluster around developmental processes and signaling: multiple terms highlight development (uterus and bone development) and nerve branching morphogenesis, plus Wnt signalosome assembly, suggesting a shared role in developmental signaling and tissue patterning. Some terms like innate immune response and manganese ion response appear as outliers, but the dominant theme is signaling-driven morphogenesis and mechanical cue responses during development.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0060065","count":5},{"id":"GO:0060348","count":5},{"id":"GO:2000172","count":4},{"id":"GO:0071260","count":4}]},{"hash":"542995005965828919","title":"Antiviral Autophagy and PML-Body Regulation","description":"The GO terms show a strong focus on autophagy and antiviral regulation (e.g., autophagy, negative regulation of viral replication/transcription, RIG-I signaling, and PML body organization), plus related ubiquitination processes and immune signaling. This points to a cohesive role in innate antiviral defense mediated by autophagy and PML nuclear bodies, justifying a unified label.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":4},{"id":"GO:0045869","count":3},{"id":"GO:0030578","count":3},{"id":"GO:0007014","count":3},{"id":"GO:0032897","count":3}]},{"hash":"1982206340269648216","title":"Ubiquitin-Dependent Degradation in Muscle Differentiation","description":"The terms cluster around ubiquitination and proteasome-mediated degradation (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, and ERAD) with skeletal muscle cell differentiation as a clear anchor; vitamin D response and transcription regulation provide context but the dominant theme is ubiquitin-driven turnover linked to muscle development.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0035914","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0016567","count":3}]},{"hash":"1355203075706506389","title":"Extracellular matrix remodeling and complement activation","description":"The cluster shows strong extracellular matrix-related processes (collagen fibril organization, cell-matrix and substrate adhesion) alongside immune signaling (complement activation via lectin and classical pathways). Additional hints of receptor tyrosine kinase signaling and regulation of osteoblast activity support a theme of ECM-immune crosstalk in bone or connective tissue contexts. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0006958","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0034381","count":3},{"id":"GO:0033689","count":3}]},{"hash":"1685722898139914776","title":"Telomeric Chromatin Silencing and Ubiquitination","description":"The top terms converge on chromatin regulation at telomeres, including subtelomeric heterochromatin formation/maintenance, histone monoubiquitination, and ubiquitin polymerization, linking to chromatin state control and genome stability (e.g., repair pathways). Some terms appear obsolete or peripheral (viral process, Fc-epsilon signaling), but the central theme supports a role in telomere-associated chromatin regulation and DNA repair.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010994","count":7},{"id":"GO:0070423","count":7},{"id":"GO:0006348","count":7},{"id":"GO:0010390","count":7},{"id":"GO:0006344","count":7}]},{"hash":"802773963063585596","title":"Vesicle trafficking and immune regulation","description":"The proteins show enrichment in membrane trafficking processes, such as ER-to-Golgi vesicle transport and regulation of GTPase activity, plus terms related to vesicle endocytosis. There are also immune-related terms (pro-T cell differentiation, type 2 immune response, IgE isotype regulation), which can be connected through vesicle trafficking roles in immune signaling and secretion. A few isolated terms like pigmentation and gravitropism are outliers, but overall the cluster centers on trafficking-associated functions with immune modulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0048294","count":1}]},{"hash":"192425925499512857","title":"Innate immune signaling","description":"Based on the top GO terms, the cluster is enriched for innate immune response, classical complement activation, and regulation of the ERK1/ERK2 cascade, pointing to involvement in immune signaling pathways. While several metabolic terms are present (e.g., glutamate biosynthesis, ammonia assimilation, fatty acid oxidation, isoprenoid biosynthesis, photorespiration), they are less represented and do not redefine the primary theme. Therefore, the label captures the dominant function of immune signaling with moderate confidence.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0097054","count":2},{"id":"GO:0019676","count":2}]},{"hash":"992585095986016303","title":"Unknown","description":"The top GO terms cover carbohydrate and glycosylation-related biosynthesis and responses (starch, glycogen, GPI anchor biosynthesis, ER glycosylation) alongside distinct bacterial thiol biosynthesis (bacillithiol, mycothiol) and various stress or behavior terms, yielding no single cohesive function for the cluster.","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007631","count":3},{"id":"GO:0033577","count":3},{"id":"GO:0071793","count":3},{"id":"GO:0019252","count":3},{"id":"GO:0009744","count":3}]},{"hash":"217847103002793923","title":"Ceramide and glycosphingolipid transport","description":"The cluster\u2019s top GO terms cluster around lipid trafficking and metabolism, especially ceramide transport (ER to Golgi, ceramide 1-phosphate) and glycosphingolipid/glycolipid metabolism, with accompanying general membrane transport terms (organic cation, polyol, ammonium). This suggests the proteins are largely membrane transporters involved in lipid trafficking, particularly sphingolipid pathways, with plant-specific links to defense signaling and growth processes such as pollen tube development. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009751","count":2},{"id":"GO:0006687","count":2},{"id":"GO:0015695","count":2},{"id":"GO:0015791","count":2},{"id":"GO:0046836","count":2}]},{"hash":"2177147791022023037","title":"ECM Remodeling and Coagulation","description":"The cluster shows strong signals for extracellular matrix remodeling, adhesion, hyaluronan metabolism, and metallopeptidase activity (blood coagulation, cellular extravasation, cartilage morphogenesis). Some terms like T cell activation and dendrite regeneration appear as peripheral annotations, but the core theme centers on ECM dynamics and tissue remodeling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0007161","count":4},{"id":"GO:0035987","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0045123","count":4}]},{"hash":"836125963497490155","title":"Neuronal signaling and excitability","description":"Most of the top GO terms point to neuron function\u2014calcium ion detection, chemical synaptic transmission, neuronal action potential, and potassium ion transport\u2014reflecting signaling and excitability in neurons. A couple terms (cellular response to bile acid, obsolete C-5 methylation) are less relevant, but the overall signal is dominated by neuronal signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090116","count":1},{"id":"GO:0005513","count":1},{"id":"GO:1903413","count":1},{"id":"GO:0007268","count":1},{"id":"GO:0019228","count":1}]},{"hash":"1245118726228242735","title":"Unknown","description":"The terms span vascular processes (blood coagulation, vasopressin-regulated blood pressure), signaling (calcium release, PKA activity), immune functions (IL-1\u03b2 production, dendritic cell differentiation), sensory maintenance (photoreceptor maintenance), and temperature response, showing no single cohesive function for the cluster. ","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":7},{"id":"GO:0051281","count":7},{"id":"GO:0045494","count":5},{"id":"GO:0001992","count":5},{"id":"GO:0071502","count":5}]},{"hash":"894837145306552585","title":"Neural development and axon guidance","description":"The terms cluster around neural development and axon pathfinding: neural crest migration, commissural and sensory neuron axon guidance, retinal ganglion and otic placode contexts, plus localization to paranode/juxtaparanode regions, with a minor link to synaptic vesicle endocytosis.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0036486","count":1},{"id":"GO:0071679","count":1},{"id":"GO:0071205","count":1},{"id":"GO:1902336","count":1},{"id":"GO:0097374","count":1}]},{"hash":"52255143391686636","title":"Eye and lens development","description":"The top GO terms point strongly to ocular development, with explicit retina development in camera-type eye and lens fiber cell differentiation, plus related patterning (left/right). Supporting terms about phagolysosome assembly in retinal maintenance and broader protein turnover/regulation fit within developmental and tissue-specific remodeling during eye formation, making a cohesive ocular development theme likely.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0071560","count":2},{"id":"GO:2000060","count":2},{"id":"GO:0043966","count":2}]},{"hash":"1602598286358770822","title":"Regulators of development and metabolism","description":"The cluster includes developmental terms (spermatogenesis, kidney development) alongside multiple \\\"positive regulation\\\" terms across metabolism (fatty acid biosynthesis, glucose metabolism) and immune/oxidative regulation (activation of membrane attack complex, SOD activity). This suggests proteins acting as regulators across development and metabolic/immunoregulatory processes rather than a single cohesive enzymatic function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007283","count":2},{"id":"GO:0001822","count":2},{"id":"GO:2000312","count":2},{"id":"GO:0001970","count":2},{"id":"GO:0045723","count":1}]},{"hash":"222077733509897394","title":"Endocytosis and actin-based trafficking","description":"These proteins are enriched for endocytosis and actin cytoskeleton remodeling (filopodium and microspike assembly) and for vesicle transport between endosomes, ER, Golgi, and plasma membrane, with regulation by Rho signaling. Innate immune signaling terms also accompany, suggesting a module where membrane trafficking and actin dynamics intersect with defense responses. Overall, the cluster appears to center on endocytic processes tied to cytoskeletal remodeling and vesicular trafficking.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006622","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0035023","count":2}]},{"hash":"835556229076455944","title":"GTPase-regulated vesicle trafficking","description":"The cluster\u2019s top GO terms cluster around GTPase activity regulation and small GTPase\u2013mediated signal transduction, coupled with protein transport and post-Golgi vesicle\u2013mediated transport, indicating a shared role in vesicle trafficking governed by GTPases. Some terms (wing hair organization, nucleotide catabolism, DNA protection, tetramerization) are more peripheral, suggesting additional, non-core functions but not overriding the central trafficking theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0006892","count":1},{"id":"GO:0007264","count":1},{"id":"GO:0035317","count":1}]},{"hash":"1250760754564324385","title":"Chromatin regulation and heterochromatin maintenance","description":"The top GO terms cluster around chromatin dynamics and genome regulation: negative regulation of chromatin binding, deneddylation and desumoylation of proteins affecting chromatin function, pericentric heterochromatin formation, and regulation of kinetochore assembly. Some placental development terms appear, but the dominant theme across terms is chromatin state control and chromosome integrity during cell division. The lack of explicit interaction data among proteins suggests a shared nuclear function rather than a biological pathway, making this label a concise reflection of the core function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035562","count":1},{"id":"GO:0060711","count":1},{"id":"GO:0032875","count":1},{"id":"GO:0000338","count":1},{"id":"GO:0016926","count":1}]},{"hash":"336570414126952955","title":"Immune Cell Apoptosis and Regulation","description":"This cluster\u2019s top GO terms center on apoptosis (execution phase, apoptotic DNA fragmentation, response to staurosporine) and immune functions (B cell homeostasis, regulation of T cell proliferation) with glucocorticoid-responsive signaling, pointing to apoptosis-driven regulation of immune cells. The compound eye development term looks like noise, but the overall pattern is cohesive around immune-cell apoptosis and its regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0048749","count":3},{"id":"GO:0072734","count":3},{"id":"GO:0006309","count":3},{"id":"GO:0009749","count":3},{"id":"GO:0046007","count":3}]},{"hash":"82166387245144048","title":"Neuronal development and synapse organization","description":"Explanation: Key terms indicate neuron development and synaptic organization\u2014synapse assembly, NMDA receptor clustering, and neuron projection morphogenesis\u2014supported by JUN phosphorylation and actin dynamics; a minor peroxisome import term is less central.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007258","count":5},{"id":"GO:0016560","count":4},{"id":"GO:0050894","count":4},{"id":"GO:0007416","count":4},{"id":"GO:1904531","count":4}]},{"hash":"1633653939039725141","title":"Developmental signaling and tissue remodeling","description":"Top GO terms indicate a mix of cytokine regulation (IL-6/IL-10), growth factor signaling (HGF receptor), GPCR/PLC signaling, Wnt/Ca2+ signaling, and cell migration, spanning developmental processes (mammary duct growth, embryo implantation) as well as neural and immune modulation. This suggests a cohesive theme of signaling pathways coordinating development, organogenesis, and tissue remodeling, rather than a single, isolated function.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032715","count":3},{"id":"GO:0032733","count":3},{"id":"GO:0048012","count":3},{"id":"GO:0014909","count":3},{"id":"GO:0007223","count":2}]},{"hash":"111492520918792587","title":"Cytoskeletal remodeling and vesicle trafficking","description":"This cluster centers on actin dynamics (lamellipodium assembly, actin cytoskeleton organization), membrane remodeling and trafficking (positive regulation of membrane tubulation, endosome organization), and small GTPase\u2013mediated signaling (activation of GTPase activity, Ral signaling, GPCR pathways), pointing to coordinated cytoskeletal rearrangement and vesicle trafficking. A couple of metabolic terms are present but appear peripheral to the main theme.","confidence":"High","size":6,"edges":6,"triangles":2,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030032","count":6},{"id":"GO:0032485","count":6},{"id":"GO:0061000","count":6},{"id":"GO:0032000","count":6},{"id":"GO:0007032","count":6}]},{"hash":"1619997633642508858","title":"Adhesion and Migration in Development and Immunity","description":"Top GO terms indicate strong emphasis on cell adhesion (matrix and cell-cell), leukocyte tethering, and directed cell movement in development (angiogenesis, kidney development) as well as neural maturation processes (axon guidance, synapse maturation). While a few terms (complement activation, thyroid hormone generation) are more peripheral, they can reflect broader signaling contexts linked to development and immune interactions. Together, these suggest a theme of adhesion-mediated signaling guiding development and immune cell behavior.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0007160","count":5},{"id":"GO:0006590","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0090050","count":5}]},{"hash":"1346703477108664882","title":"Neural Development and Synapse Signaling","description":"The dominant terms point to neural development, synapse assembly/maintenance, and regulation of excitatory (glutamatergic) transmission, with retinal development and cell-matrix adhesion supporting neural connectivity. While there are immune/coagulation terms (complement activation, plasminogen activation, fibrinogen regulation), the core signal across the cluster centers on neural development and synaptic function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0031639","count":6},{"id":"GO:0007160","count":6},{"id":"GO:0051968","count":6},{"id":"GO:0045907","count":6}]},{"hash":"473966920912531665","title":"Unknown","description":"The top GO terms cluster around immune cell adhesion and signaling (integrin signaling, T cell activation, cell adhesion, coagulation), but the presence of plant-specific processes (chlorophyll biosynthesis, stamen formation) suggests the annotations do not reflect a single coherent function. Therefore no clear, representative theme.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":4},{"id":"GO:0001867","count":3},{"id":"GO:0034113","count":3},{"id":"GO:0002291","count":3},{"id":"GO:0007596","count":3}]},{"hash":"464872738919853693","title":"Integrin-Mediated Adhesion and Cell Migration","description":"The top GO terms cluster around cell-matrix and cell-cell adhesion, integrin signaling, extracellular matrix remodeling, and cell migration/extravasation. Additional signals related to coagulation and immune cell activation fit within vascular and immune cell movement contexts, supporting a cohesive theme of adhesion-driven migration mediated by integrins. A few terms (like endodermal differentiation) are peripheral, but do not dominate the cluster\u2019s core function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007161","count":5},{"id":"GO:0034113","count":4},{"id":"GO:0007229","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0045123","count":4}]},{"hash":"583112304172991837","title":"Regulation of transcription, signaling, and protein turnover","description":"This cluster includes transcriptional regulation (negative regulation of transcription by RNA polymerase II) and protein turnover (protein ubiquitination, ERAD-related terms), along with signaling-related and regulatory processes (response to vitamin D, sensory/pain detection, synaptic plasticity regulation), plus broader regulatory roles (spindle assembly, telomere maintenance, brown fat differentiation). The common thread is broad cellular regulation and signaling rather than a single pathway, so a label reflecting regulatory functions is appropriate.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0016567","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0050968","count":3}]},{"hash":"130771173400664602","title":"Spindle assembly and microtubule dynamics","description":"This cluster is dominated by GO terms on mitotic spindle assembly, kinetochore microtubule attachments and microtubule-based processes, including minus-end\u2013directed sliding and spindle orientation, indicating a core role in microtubule dynamics and spindle organization across cell division contexts.","confidence":"High","size":6,"edges":8,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021685","count":6},{"id":"GO:0033624","count":6},{"id":"GO:0099607","count":6},{"id":"GO:0031534","count":6},{"id":"GO:0051296","count":6}]},{"hash":"31363134767053792","title":"Neuronal Synaptic Actin Remodeling and Plasticity","description":"The terms heavily point to actin cytoskeleton dynamics (actin nucleation and filament binding) and synaptic processes (NMDA receptor clustering and long-term potentiation), all of which are central to synaptic strength regulation via actin remodeling and receptor trafficking. While a couple of terms seem less directly related (e.g., peroxisome docking, heart development), the prevailing pattern supports a module involved in neuronal synaptic remodeling and plasticity.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016560","count":5},{"id":"GO:0050894","count":5},{"id":"GO:1904531","count":5},{"id":"GO:0097114","count":5},{"id":"GO:0007507","count":5}]},{"hash":"229762740669165978","title":"Muscle and Nervous System Development","description":"These terms cluster around development of muscle and peripheral nerves (myoblast fusion, heart and Schwann cell development) with accompanying neural signaling (synaptic potentiation, EPSP) and responses to muscle activity, suggesting a protein set involved in muscle-nerve development and function.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0007520","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0014044","count":3}]},{"hash":"1574885320246741625","title":"Innate Immune Signaling and Inflammation","description":"The top GO terms point to innate immune recognition and inflammatory signaling, with MyD88-dependent TLR signaling, responses to peptidoglycan and fungal components, immunoglobulin-mediated response, and cytokine/chemokine regulation (including IL-17 production). While a generic protein processing term appears, the dominant pattern is innate immune activation and inflammatory response in reaction to microbial stimuli.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016485","count":3},{"id":"GO:0016064","count":3},{"id":"GO:0002755","count":3},{"id":"GO:0032494","count":3},{"id":"GO:0002238","count":3}]},{"hash":"123260234876260524","title":"Neuromuscular junction assembly","description":"The leading GO terms point to postsynaptic membrane assembly and regulation of acetylcholine receptor clustering in skeletal muscle, which are hallmarks of neuromuscular junction (NMJ) formation. BMP signaling can participate in muscle development, supporting the context, while other terms are less coherent and may reflect annotation noise. Overall, the strongest common theme is NMJ assembly, making Neuromuscular junction assembly a concise, representative label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097104","count":2},{"id":"GO:0007567","count":1},{"id":"GO:2000055","count":1},{"id":"GO:0030509","count":1},{"id":"GO:1904395","count":1}]},{"hash":"1810931346373086103","title":"Nuclear transport and transcription regulation cluster","description":"This cluster shows enrichment in nuclear import/export processes (NLS-bearing and ribosomal protein import; regulation of protein export) and transcription regulation (negative regulation of RNA polymerase II), with additional signals related to stress signaling (positive regulation of JNK cascade) and xenobiotic response. The common theme appears to be proteins involved in nuclear-cytoplasmic trafficking and transcriptional/stress responses, though other GO terms suggest broader functional diversity. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0090557","count":2},{"id":"GO:0046330","count":2},{"id":"GO:0042176","count":1}]},{"hash":"605435539774178042","title":"Actin Remodeling and Immune Cell Signaling","description":"The top terms cluster around actin cytoskeleton remodeling (filament polymerization, filopodium assembly), cell polarity and shape maintenance, and cell migration/adhesion, especially in immune contexts (dendritic cell migration, T cell receptor signaling). The inclusion of signaling pathways like ephrin receptor and canonical Wnt signaling further supports a theme where cytoskeletal dynamics are tightly coupled to cell signaling during immune cell movement and interaction.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0030838","count":3},{"id":"GO:0046847","count":3}]},{"hash":"21451159946506579","title":"Unknown","description":"The terms cover DNA replication initiation, ribosome biogenesis, rRNA processing, development, and stress responses, with no single function tying all proteins together. This lack of a cohesive theme makes a specific label unreliable.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030174","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0006267","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0030318","count":1}]},{"hash":"2090368408435921527","title":"Regulators of cell proliferation and signaling","description":"This cluster centers on GO terms that mention positive regulation of cell proliferation, phosphorylation, exocytosis, cytokinesis, EMT, and responses to glucocorticoids, suggesting proteins that broadly modulate signaling pathways, cell growth, and vesicle trafficking. Some terms (memory, ascospore formation) are less directly connected but can reflect conserved regulatory roles in development and stress responses. Overall, it seems to group regulatory proteins affecting growth, differentiation, and trafficking rather than a single specific process.","confidence":"Medium","size":6,"edges":9,"triangles":4,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008284","count":5},{"id":"GO:0007613","count":5},{"id":"GO:0030437","count":5},{"id":"GO:0006607","count":5},{"id":"GO:0051384","count":5}]},{"hash":"2174033547770703833","title":"Post-transcriptional RNA processing and splicing regulation","description":"The proteins cluster around post-transcriptional RNA processing events: spliceosome-mediated splicing regulation (including both positive and negative regulation), mRNA polyadenylation and modification, mRNA stabilization, and translation reinitiation, plus small-subunit processome assembly. This points to a cohesive theme of RNA maturation and fate control after transcription, with blastocyst formation likely a developmental association rather than its core function.","confidence":"High","size":6,"edges":6,"triangles":1,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001825","count":4},{"id":"GO:0031047","count":4},{"id":"GO:1900363","count":4},{"id":"GO:0006378","count":4},{"id":"GO:0048255","count":4}]},{"hash":"1477460650457616683","title":"Ribosome biogenesis and translation initiation","description":"The cluster is enriched with terms for ribosome assembly (ribosomal large subunit biogenesis) and initiation of translation (formation of translation preinitiation complex, translation reinitiation). While there are a couple of RNA processing terms (spliceosome regulation) appearing, the dominant themes are ribosome biogenesis and control of protein synthesis initiation, suggesting a cohort of proteins involved in making and starting translation. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0000381","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0007175","count":2}]},{"hash":"39464399931328200","title":"Nuclear import and NPC assembly","description":"This cluster strongly centers on nuclear transport: multiple GO terms describe import of proteins into the nucleus (including NLS-bearing and ribosomal proteins) and assembly of the nuclear pore complex, suggesting a cohesive role in nuclear trafficking and NPC assembly; other terms may reflect broader regulatory or cytoskeletal functions but do not override the core theme.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042176","count":2},{"id":"GO:0060188","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0006610","count":2},{"id":"GO:0000060","count":2}]},{"hash":"1721550441070335107","title":"Developmental Gene Expression Regulation","description":"The listed terms point to gene expression control in development: nervous system development, spermatid nucleus differentiation, and photoreceptor development show tissue-specific developmental roles, while mRNA export, transcription-coupled chromatin remodeling, and nonsense-mediated decay point to the mechanisms of RNA processing and transcription regulation that support developmental programs. Despite no direct interaction edges, the common theme is regulation of gene expression during development, so a label like Developmental Gene Expression Regulation captures the cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0060212","count":1},{"id":"GO:0006406","count":1},{"id":"GO:2000780","count":1},{"id":"GO:0007289","count":1}]},{"hash":"1450535147747444514","title":"Neuronal signaling and microtubule dynamics","description":"This cluster combines neuronal excitability terms (action potential, membrane hyperpolarization, potassium export, pain detection) with cytoskeletal functions (microtubule polymerization and bundle formation), and a brain development term (globus pallidus development), suggesting proteins that participate in both neural signaling and microtubule organization in neurons.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019228","count":2},{"id":"GO:0046785","count":1},{"id":"GO:0001578","count":1},{"id":"GO:0021759","count":1},{"id":"GO:0071286","count":1}]},{"hash":"2267710172882973099","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0045723","count":2},{"id":"GO:0007568","count":2},{"id":"GO:1901671","count":2},{"id":"GO:0010907","count":2}]},{"hash":"1887978506212185518","title":"Developmental morphogenesis and EMT","description":"This cluster shows strong enrichment for developmental and morphogenetic processes: skin development, neural crest formation, angiogenesis, and epithelial-to-mesenchymal transition (EMT). The co-occurrence of GO:0043588 (skin development), GO:0014029 (neural crest formation), GO:0001525 (angiogenesis), and GO:0001837 (EMT) suggests a cohesive theme of tissue remodeling during development. Additional terms related to proliferation and neural functions (GO:0008284 and GO:0007613) are compatible with growth and memory-related processes in developing systems. Some items like ascospore formation and NLS-bearing protein import into nucleus are more general or context-dependent but do not override the central morphogenetic signal. Therefore the label Developmental morphogenesis and EMT captures the core theme.","confidence":"Medium","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043588","count":4},{"id":"GO:0008284","count":3},{"id":"GO:0007613","count":3},{"id":"GO:0030437","count":3},{"id":"GO:0006607","count":3}]},{"hash":"1496138835273521261","title":"Ribosome Biogenesis and Translation with Cell Division","description":"Primarily features GO terms for ribosome biogenesis, cytoplasmic translation, and ribosomal subunit biogenesis, indicating a core focus on protein synthesis machinery. The presence of cell division and cell cycle terms suggests these proteins may coordinate ribosome production with cell proliferation. Some regulatory stress-response terms appear as secondary associations, but the dominant theme ties to ribosome assembly and translation in the context of cell division.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:1901001","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0000747","count":2},{"id":"GO:1903833","count":2}]},{"hash":"2002766166849301830","title":"Developmental tissue morphogenesis","description":"The terms indicate morphogenesis and development across multiple tissues (placental branching, dorsal root ganglion morphogenesis, cerebellar Purkinje cell layer development, retinal axon guidance, neuromast hair cell differentiation) with associated signaling (ECM-cell signaling, PKC regulation), suggesting a shared theme of developmental tissue morphogenesis rather than a single specific function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060672","count":2},{"id":"GO:0007567","count":1},{"id":"GO:1902336","count":1},{"id":"GO:0090036","count":1},{"id":"GO:0048903","count":1}]},{"hash":"1201130481914579213","title":"Bacterial metabolite biosynthesis and sporulation","description":"This cluster\u2019s top GO terms cluster around bacterial biosynthetic activities (poly-hydroxybutyrate biosynthesis, antibiotic biosynthesis) and development (sporulation), with supporting references to redox processes and general metabolism (ribosomal assembly, phenylacetate catabolism). While some terms are broader or archaic, the strongest signal is a bacterial metabolism/biogenesis theme centered on metabolite production and spore formation, rather than a single, cohesive pathway.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042619","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0010216","count":1}]},{"hash":"1747943930026802596","title":"Neuronal adhesion and synapse assembly","description":"The GO terms cluster around cell\u2013cell adhesion (heterophilic and homophilic), nervous system development, and positive regulation of synapse assembly, indicating roles in neuronal adhesion molecules and synaptogenesis. Signaling activities like protein autophosphorylation and STAT tyrosine phosphorylation support adhesion and synapse formation processes. Some terms (ossification, inflammatory wound healing) are less central, but the dominant theme is neural connectivity and synapse formation.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007156","count":2},{"id":"GO:0043931","count":2}]},{"hash":"2081376586403855919","title":"RNA Polymerase II Transcription Regulation and Initiation","description":"This cluster centers on GO terms related to RNAP II transcription elongation, preinitiation complex assembly, and chromatin-related regulation, suggesting proteins that coordinate transcription initiation/elongation with chromatin state.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001193","count":1},{"id":"GO:0060303","count":1},{"id":"GO:2001253","count":1},{"id":"GO:0006362","count":1},{"id":"GO:0010793","count":1}]},{"hash":"1506253250285414621","title":"Unknown","description":"GO terms span plant and animal development, nervous system and organ development, ion transport, and sensory/immune processes with no coherent shared function; no network connectivity suggests no common theme to assign a specific label.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055046","count":1},{"id":"GO:0045466","count":1},{"id":"GO:0010262","count":1},{"id":"GO:0071502","count":1},{"id":"GO:0097623","count":1}]},{"hash":"369452357561027691","title":"Unknown","description":"The GO terms for this cluster cover morphine response, glucose transport, SMAD signaling, RNA polymerase III preinitiation assembly and transcription regulation, as well as development and pheromone-related terms. The functions are too disparate to infer a single coherent biological theme or process driving the cluster, suggesting annotation noise or broad, multi-functional proteins rather than a unified pathway.","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0060395","count":1},{"id":"GO:0070898","count":1},{"id":"GO:0007329","count":1}]},{"hash":"1846935950236419189","title":"Embryonic craniofacial and hindbrain development","description":"These proteins are associated with craniofacial (roof of mouth, skeletal development) and hindbrain patterning (rhombomeres 4/5, brain segmentation, retrotrapezoid nucleus neuron differentiation) during embryogenesis, with a notable emphasis on transcriptional regulation (negative regulation of RNA Pol II). This suggests a cohesive role in early developmental patterning rather than a single metabolic function.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0007501","count":1}]},{"hash":"1647835625536962837","title":"Cytoskeleton Remodeling in Immune Cell Dynamics","description":"The cluster shows themes of actin remodeling, cell spreading and migration during wound healing, macrophage differentiation, and mast cell degranulation, suggesting cytoskeleton-dependent immune cell dynamics. Some mitosis and NF-kB regulation terms are present but secondary.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043124","count":2},{"id":"GO:1902307","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0007097","count":2},{"id":"GO:0044319","count":2}]},{"hash":"1040065586362333934","title":"Cardiovascular development and valve formation","description":"The terms cluster around heart and blood vessel development, including endocardial cushion to mesenchymal transition involved in heart valve formation and vascular remodeling, with supporting signals related to inflammation and hematopoietic lineage processes. The shared theme appears to be cardiovascular development and valve morphogenesis, with related remodeling events. ","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902895","count":3},{"id":"GO:0055114","count":3},{"id":"GO:2000504","count":2},{"id":"GO:0007296","count":2},{"id":"GO:0035855","count":2}]},{"hash":"997880553342217657","title":"Unknown","description":"The top terms are highly heterogeneous, including EMT, classical complement activation, memory, nuclear import, glucocorticoid response, cytokinesis regulation, and even ascospore formation. There is no single cohesive biological function tying all six proteins together, suggesting the cluster spans unrelated processes rather than a specific pathway or function.","confidence":"","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001837","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0008284","count":1},{"id":"GO:0007613","count":1},{"id":"GO:0030437","count":1}]},{"hash":"353284136864529013","title":"Diverse biosynthetic and metabolic processes","description":"This cluster\u2019s top GO terms cover a wide range of biosynthetic and metabolic activities (galactose, retinol, poly-hydroxybutyrate, antibiotic, and anthocyanin biosynthesis) as well as general oxidation-reduction and regulatory activities. The lack of a single cohesive pathway and the diversity of substrates suggest a broad metabolic theme rather than a unique function, making a label like \u201cDiverse biosynthetic and metabolic processes\u201d most representative.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0030435","count":2},{"id":"GO:0006012","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0042572","count":2}]},{"hash":"187484958287975557","title":"Inflammatory Cytokine Signaling","description":"Several GO terms converge on immune/inflammatory signaling: cytokine production (IL-1\u03b2, IL-12, IL-17), inflammatory response, immunoglobulin-mediated immune response, and responses to lipoteichoic acid, with regulation of NF-kappaB and JNK pathways. Together these indicate a cluster of proteins involved in cytokine-driven inflammatory signaling and host defense.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016064","count":3},{"id":"GO:0070671","count":3},{"id":"GO:0071223","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0006954","count":3}]},{"hash":"981160160713594309","title":"Embryonic Development and Immune Signaling","description":"The proteins show a broad developmental theme, with GO terms for palate, thyroid, skeletal muscle, mesodermal fate, rhombomere development, and embryonic skeletal system development, suggesting a cluster tied to embryogenesis and tissue formation. A couple of terms related to immune signaling (IL-10 production, B cell receptor signaling) appear, which may reflect immune\u2013development interactions or annotation overlap. Overall, the label captures the dominant developmental context with a modest immune-related component.","confidence":"Medium","size":6,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":4},{"id":"GO:0030878","count":4},{"id":"GO:0007519","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0032613","count":3}]},{"hash":"914477528977954778","title":"Developmental patterning and tissue morphogenesis","description":"This cluster shows a clear emphasis on developmental patterning and morphogenesis across multiple tissues (left/right axis specification, neural retina development, foregut morphogenesis, skin epidermis development, R8 cell development, crystal cell differentiation). While a few terms are broader or unrelated (memory, blood coagulation, ATP response), the dominant signal is embryonic development and organ/tissue morphogenesis. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0007613","count":4},{"id":"GO:0070986","count":4},{"id":"GO:0061074","count":4},{"id":"GO:0007596","count":4}]},{"hash":"1041449344232734338","title":"Transmembrane sugar and ion transporters","description":"This cluster is dominated by GO terms for transmembrane transport of sugars (glucose, galactose, D-xylose, fucose) and other ions, plus a related neurotransmitter loading into synaptic vesicles, indicating a group of membrane transporter proteins with varied substrates. An occasional outlier (positive regulation of replicative senescence) is present but not representative of the core function.","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":3},{"id":"GO:0098700","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0070715","count":3},{"id":"GO:0006004","count":3}]},{"hash":"1052493764754428743","title":"Skeletal development and epidermal differentiation","description":"This cluster is dominated by GO terms for skeletal system development and cartilage condensation, plus keratinocyte differentiation, indicating involvement in bone/cartilage and skin differentiation. The presence of DNA-templated transcription and DNA replication terms suggests regulatory roles in gene expression during development, while additional terms (FSH signaling, PI3K/AKT signaling, apoptosis regulation, brown fat differentiation) point to broader differentiation and signaling contexts that can accompany developmental programs. Overall, the proteins appear to participate in differentiation processes across skeletal and epidermal lineages.","confidence":"Medium","size":6,"edges":8,"triangles":3,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0001501","count":3},{"id":"GO:0030216","count":3},{"id":"GO:0019233","count":3}]},{"hash":"336633399925616429","title":"Ubiquitin-Dependent Proteostasis and Aggresome Formation","description":"The top GO terms center on ubiquitin-mediated protein degradation (including K48- and K63-linked ubiquitination, autoubiquitination) and aggresome assembly, with additional hints of histone turnover and signaling regulation. This suggests a cohesive cluster of proteins involved in ubiquitin signaling, proteostasis, and handling of misfolded/aggregated proteins.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0036205","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0070936","count":3}]},{"hash":"432316249854000223","title":"Terpenoid and sterol biosynthesis","description":"This cluster is dominated by GO terms for the synthesis of isoprenoid compounds\u2014farnesyl and geranyl diphosphate pathways, monoterpenes, cholesterol, and quinones\u2014pointing to a shared terpenoid/isoprenoid biosynthetic function. A couple of housekeeping terms (protein transport, translation) appear but are much less representative of the core theme. Overall, the terms cohere around lipid-derived biosynthesis rather than a single protein complex, supporting the label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006695","count":2},{"id":"GO:0045337","count":2},{"id":"GO:0051290","count":2},{"id":"GO:0015031","count":2},{"id":"GO:1901663","count":2}]},{"hash":"1896944722912190030","title":"Diverse Metabolic Biosynthesis","description":"The GO terms point to multiple biosynthetic and catabolic pathways (alkaloids, serotonin from tryptophan, taurine, sphingolipids, glutamate) and to regulatory/homoeostatic processes (circadian rhythm, intracellular pH, luteinization), with occasional stress responses (pyrethroid). This suggests a cluster centered on broad metabolism and small-molecule biosynthesis rather than a single dedicated pathway.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":3},{"id":"GO:0007623","count":3},{"id":"GO:0006587","count":3},{"id":"GO:0001553","count":3},{"id":"GO:0042412","count":3}]},{"hash":"1555918214293839741","title":"Broad-spectrum membrane transporters","description":"The cluster shows multiple transmembrane transport GO terms across a wide range of substrates (xenobiotics, potassium ions, vitamins, bacteriocins, pheromones, phospholipids, and amino acids like cysteine), indicating proteins functioning as versatile membrane transporters rather than a single substrate-specific family.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0071805","count":4},{"id":"GO:0042908","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0030153","count":3}]},{"hash":"736772683304567647","title":"Unknown","description":"These proteins have a highly diverse set of GO terms, spanning lung development, ascospore formation, epithelial\u2013mesenchymal transition, locomotion, T cell homeostasis, metal ion response, dephosphorylation, and DNA damage/meiotic recombination processes. There is no clear, single biological theme uniting these terms, suggesting either broad, non-specific roles or annotation noise. Therefore, a precise, representative cluster name cannot be determined.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":3},{"id":"GO:0030437","count":2},{"id":"GO:1903501","count":2},{"id":"GO:0031987","count":2},{"id":"GO:0001837","count":2}]},{"hash":"18946191883151298","title":"Actin Nucleation and Filament Assembly","description":"The top GO terms are dominated by Arp2/3 complex-mediated actin nucleation, actin filament polymerization, and actin cortical patch assembly, pointing to a shared function in actin cytoskeleton remodeling. While some terms relate to transport or regulatory pathways, the strongest cohesive signal across the cluster is actin assembly processes, suggesting these proteins may participate in cytoskeletal dynamics rather than membrane transport. The absence of edges or triangles indicates no inferred direct interactions within the cluster, but the GO profile still supports a common theme of actin organization.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034314","count":1},{"id":"GO:0030041","count":1},{"id":"GO:0000147","count":1},{"id":"GO:1901207","count":1},{"id":"GO:0015991","count":1}]},{"hash":"2280077956096200061","title":"Unknown","description":"The GO terms span mitotic cell cycle, neuronal signaling, Schwann cell development, fungal ascospore formation, EMT, kinetochore localization, NFAT signaling, meiotic cell cycle, cocaine response, and miRNA processing regulation. These terms come from diverse biological contexts and do not converge on a single clear function or pathway, making a cohesive label difficult. Therefore, Unknown is the most appropriate name.","confidence":"","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0030437","count":3},{"id":"GO:0001837","count":3}]},{"hash":"124899261548075448","title":"Type 2 immune response regulation","description":"These proteins are linked by GO terms that center on type 2 immunity, including regulation of IgE isotype switching, mast cell cytokine production, and T cell differentiation (pro-T cell and memory T cell). Although a few terms reference non-immune processes, the strongest and most frequent signals point to modulation of Th2-type immune responses and related lymphocyte function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048294","count":5},{"id":"GO:2000176","count":5},{"id":"GO:0042092","count":5},{"id":"GO:0009958","count":5},{"id":"GO:0032764","count":5}]},{"hash":"1182349635501772501","title":"Endosomal sorting and vesicle trafficking","description":"Based on GO terms, the cluster centers on endocytic and vesicle trafficking processes: recycling of endosomes, transport between early and late endosomes, multivesicular body formation and sorting, and Cvt pathway targeting to the vacuole. Ubiquitination also appears, which often regulates sorting and trafficking, with supporting hints from cytoskeletal remodeling (stress fibers, mechanical response). Together these terms point to endosomal sorting and vesicle trafficking as the core theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043149","count":3},{"id":"GO:0032456","count":3},{"id":"GO:0032258","count":3},{"id":"GO:0071985","count":3},{"id":"GO:0045022","count":3}]},{"hash":"1718650611122739054","title":"Apoptosis and Immune Signaling Cluster","description":"Top GO terms point to apoptotic pathways (execution phase, p53-mediated DNA damage response) alongside innate and adaptive immune signaling (innate immune response, T cell receptor signaling, muramyl dipeptide response). Additional terms involve metabolism and growth regulation, suggesting a broader stress-response network coordinating cell fate, metabolism, and immune cues. Given the mixture, the label focuses on the core themes of apoptosis and immune signaling without overcommitting to a single process.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0032000","count":2},{"id":"GO:0097194","count":2},{"id":"GO:0042771","count":2},{"id":"GO:0045087","count":2}]},{"hash":"1418726071160183028","title":"Redox Homeostasis and Antioxidant Metabolism","description":"The cluster is strongly enriched for redox- and antioxidant-related GO terms: cellular oxidant detoxification, redox homeostasis, glutathione metabolic process, L-ascorbic acid metabolic process, and protein glutathionylation, indicating detoxification and thiol-based redox regulation. Additional terms such as toxin catabolic process and nucleotide-excision repair align with responses to oxidative stress and DNA protection, supporting a cohesive theme of redox balance and antioxidant defense.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0019852","count":4},{"id":"GO:0009407","count":4},{"id":"GO:0009072","count":4}]},{"hash":"797504430157377817","title":"Unknown","description":"The GO terms covered here are highly diverse (mRNA stability, renal water transport, aging, G1/S cell cycle regulation, redox homeostasis, cAMP response, DNA repair, keratinocyte/corneocyte development, xenobiotic response). There is no clear, single functional theme binding these proteins, and the cluster lacks interaction evidence (edges 0), so a cohesive label isn\u2019t supported.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043488","count":1},{"id":"GO:2001153","count":1},{"id":"GO:0007568","count":1},{"id":"GO:1900087","count":1},{"id":"GO:0045454","count":1}]},{"hash":"947802879055845130","title":"Inflammation-Linked Tissue Morphogenesis","description":"The cluster combines immune-related GO terms (inflammatory response, TLR9 signaling, IL-6 production) with developmental and morphogenesis terms across tissues (nipple, kidney, lung, neural development). This suggests a theme where inflammatory signaling intersects with tissue development and remodeling, rather than a single, narrow function.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0072224","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0034162","count":1}]},{"hash":"1274750460453376874","title":"Cerebellar granule cell differentiation and synaptic plasticity","description":"The top GO terms center on cerebellar granule cell differentiation and learning-related synaptic modulation, including prepulse inhibition, startle response, conditioned taste aversion, long-term synaptic depression, receptor clustering, vesicle fusion regulation, and receptor internalization, indicating cerebellar development with dynamic synaptic plasticity.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":2},{"id":"GO:0060134","count":1},{"id":"GO:0043113","count":1},{"id":"GO:0001661","count":1},{"id":"GO:0001964","count":1}]},{"hash":"1284038139750094273","title":"Diverse developmental morphogenesis","description":"These GO terms cover broad developmental and morphogenetic processes across tissues and species, including gland development (prostate, mammary), eye-related structures (lens placode), imaginal disc fusion in insects, vitellogenesis, and regulation of signaling pathways (activin receptor signaling, protein tyrosine kinase activity). The common theme is general developmental patterning and tissue formation rather than a single specific pathway, justifying a label centered on diverse developmental morphogenesis.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060527","count":1},{"id":"GO:0007296","count":1},{"id":"GO:0032925","count":1},{"id":"GO:0032000","count":1},{"id":"GO:0046619","count":1}]},{"hash":"672236525188422246","title":"Unknown","description":"The GO terms for this cluster span neural signaling (excitatory postsynaptic potential, conditioned taste aversion), signaling pathways (canonical Wnt signaling pathway), calcium transport, and broad developmental processes (trophoblast giant cell differentiation, skeletal system development). With no single cohesive function tying these together and several unrelated themes, there isn\u2019t a clear, specific label to assign beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":2},{"id":"GO:0060070","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0098703","count":2}]},{"hash":"263104847285348896","title":"Myelin lipid biosynthesis and myelination","description":"The dominant GO terms are myelination and galactosylceramide biosynthesis, pointing to proteins involved in producing myelin lipids; the other terms suggest vascular and metabolic context that can accompany neural tissue remodeling but are less defining of the core function.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0006682","count":2},{"id":"GO:0043535","count":1},{"id":"GO:0003085","count":1},{"id":"GO:0042593","count":1}]},{"hash":"1816161081617457454","title":"Carbohydrate metabolism cluster","description":"The non-obsolete GO terms center on sugar processing: galactose metabolic process, D-sorbitol biosynthetic process, and inositol catabolic process, suggesting a carbohydrate metabolism theme. There is a minor related regulatory signal (regulation of Rho protein signal transduction) and some unrelated or obsolete terms, so the connection is present but not strongly cohesive. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0019310","count":1},{"id":"GO:0006061","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0006012","count":1}]},{"hash":"1252338113775195585","title":"Unknown","description":"The top GO terms span xenobiotic response, cell wall and macromolecule catabolism, heat generation, neural/visual functions, renal regulation, and viral processes, with no clear shared function among the six proteins. The absence of edges and a cohesive theme makes a specific, representative label unlikely.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0031649","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0007601","count":2}]},{"hash":"2260065020288102206","title":"Developmental signaling and actin remodeling","description":"This cluster centers on developmental signaling (myoblast fusion, telencephalon and multicellular development) and cytoskeletal remodeling (actin cytoskeleton reorganization, actin filament binding). The presence of translation regulation and JNK pathway modulation suggests coordinated growth and differentiation processes that involve changes in cell shape and polarity, consistent with muscle and neural development.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038162","count":5},{"id":"GO:0007520","count":5},{"id":"GO:0021537","count":5},{"id":"GO:0045727","count":5},{"id":"GO:0031532","count":5}]},{"hash":"608286864899855565","title":"Neuronal ion transporters and vesicle loading","description":"These proteins show a clear emphasis on transmembrane transport of multiple ions (potassium, sodium, phosphate, nitrate/nitrite) and processes tied to nerve impulse transmission and neurotransmitter loading into synaptic vesicles. The dominant theme is neuronal membrane transport and vesicle-associated neurotransmission, suggesting these proteins function as neuronal transporters and vesicle-loading components, despite a few unrelated metabolic annotations. ","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0051971","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0006004","count":2}]},{"hash":"165095667417859147","title":"BMP/TGF-\u03b2 Signaling Negative Regulators","description":"The top GO terms point strongly to inhibition of BMP signaling and TGF-\u03b2 receptor signaling, including SMAD-related regulation and peptidyl-threonine dephosphorylation, suggesting these proteins act as negative regulators of this pathway. Some plant-specific terms present may reflect broader regulatory roles, but the central theme is consistent: dampening BMP/TGF-\u03b2 signaling through dephosphorylation and SMAD pathway modulation.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":2},{"id":"GO:0030512","count":2},{"id":"GO:0010991","count":2},{"id":"GO:0000173","count":1},{"id":"GO:0035970","count":1}]},{"hash":"200835462188763083","title":"Integrin signaling and ECM remodeling","description":"The terms cluster around cell-ECM interactions: integrin-mediated signaling, hyaluronan metabolism, cell-cell adhesion, metallopeptidase regulation, and substrate-dependent migration. These point to processes that govern adhesion to the extracellular matrix and remodeling of the matrix, which coordinate signaling and movement. Some terms like stamen formation and proteasome assembly are less central but do not override the dominant ECM/adhesion theme.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:1905050","count":5},{"id":"GO:0030212","count":5},{"id":"GO:0034113","count":4},{"id":"GO:0002291","count":4}]},{"hash":"2227562310992231004","title":"Lectin-mediated complement activation and innate immune signaling","description":"The top terms point to innate immune functions: activation of the lectin pathway of complement, C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, and responses to fungal components. These together suggest a cohesive theme of lectin- and antibody-driven innate immune signaling. Some development- or adhesion-related terms appear but are likely secondary or contextual, not defining the core function of the cluster.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0007161","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0072237","count":2},{"id":"GO:0071226","count":2}]},{"hash":"1840175529928587575","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0006458","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0046825","count":1},{"id":"GO:1901621","count":1}]},{"hash":"1400054582570656331","title":"Developmental ECM Adhesion and Immune Signaling","description":"The top GO terms point to cell-matrix adhesion as a central activity (with cartilage condensation and various development-related terms such as mesonephric/metanephric development), suggesting roles in extracellular matrix interactions during tissue formation. The presence of immune-related terms (complement activation lectin pathway, leukocyte tethering) alongside developmental cues indicates these proteins may participate in both adhesion during organogenesis and modulate immune-related processes, rather than representing a single, narrow function.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0001502","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0090238","count":3},{"id":"GO:0060074","count":2}]},{"hash":"1383346948530513279","title":"Mitophagy and Mitochondrial Fusion Regulation","description":"The cluster is driven by themes of mitochondrial quality control: both positive and negative regulation of mitochondrial fusion, plus mitophagy/autophagy-related terms, suggesting a coordinated regulation of mitochondrial dynamics and turnover. Post-translational modifications like sumoylation and deubiquitination likely modulate these processes, while remaining translation-related terms may reflect housekeeping components co-clustered with these pathways. Overall, the dominant signal points to mitochondrial fusion control and mitophagy.","confidence":"High","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":4},{"id":"GO:0010636","count":3},{"id":"GO:0016579","count":3},{"id":"GO:0017085","count":3},{"id":"GO:0000753","count":3}]},{"hash":"1525903974421509209","title":"DNA replication and genome maintenance","description":"The cluster is dominated by GO terms for DNA replication and genome integrity, including DNA unwinding, replication, and topological changes, as well as DNA damage response and repair (SOS, double-strand break repair, telomere maintenance). UV protection and RNA surveillance appear as additional stress-related processes that accompany replication-related functions, with transcription initiation and viral genome replication being less central. These collectively point to a group of proteins involved in maintaining genome stability during replication and stress.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006268","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0009650","count":2},{"id":"GO:0006265","count":2},{"id":"GO:0000184","count":2}]},{"hash":"2246343223526518132","title":"Ubiquitin-mediated immunity and chromatin regulation","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes and protein ubiquitination, plus histone catabolic/ubiquitination events, indicating ubiquitin signaling affecting protein turnover and chromatin. The presence of adaptive immune response and V(D)J recombination suggests immune-system relevance, potentially through ubiquitin-regulated signaling pathways like NF-kappaB. Taken together, the terms point to a theme of ubiquitin-mediated control of immune signaling and chromatin remodeling. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0002250","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0043066","count":3}]},{"hash":"1229889974443729462","title":"Nuclear transcriptional regulation and chromatin dynamics","description":"The top terms cluster around nuclear functions: regulation of gene expression via chromatin/chromatin-associated processes (including DNA methylation-related regulation), negative regulation of DNA binding and transcription factor activity, and PML body organization. Deubiquitination also fits into regulation of transcriptional machinery and chromatin state. Although a couple of terms point to other processes (ribosome assembly, endocytosis, calcium channel regulation), the dominant theme is nuclear regulation of transcription and chromatin dynamics, suggesting a cohesive functional module related to transcriptional control and chromatin modification.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":5},{"id":"GO:0000028","count":5},{"id":"GO:0010636","count":5},{"id":"GO:1900186","count":5},{"id":"GO:0043433","count":5}]},{"hash":"925392102745690086","title":"DNA Damage Response and Repair","description":"The proteins are enriched for terms related to DNA damage sensing and repair, including double-strand break repair via synthesis-dependent strand annealing, DNA strand displacement and invasion, SOS response, and cellular responses to X-ray and gamma radiation, as well as meiotic recombination. Translation appears as a minor, likely incidental term. Overall, the cluster centers on DNA damage response and repair pathways activated by radiation and DNA breaks.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000732","count":3},{"id":"GO:0001932","count":3},{"id":"GO:0045003","count":3},{"id":"GO:0009432","count":3}]},{"hash":"1307692859354281319","title":"Membrane trafficking and signaling regulators","description":"The GO terms emphasize regulation of membrane trafficking and signaling processes: endocytosis, ER membrane insertion, calcium channel regulation, and neurotransmitter secretion, plus deubiquitination that tunes protein turnover. A weaker link is ribosomal assembly and DNA methylation, which appear less connected to the main theme. Overall, the cluster is best described as regulators of membrane trafficking and intracellular signaling.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":5},{"id":"GO:0000028","count":5},{"id":"GO:0010636","count":5},{"id":"GO:1900186","count":5},{"id":"GO:0016579","count":5}]},{"hash":"823867855351912128","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0031126","count":1},{"id":"GO:0001711","count":1},{"id":"GO:2001209","count":1}]},{"hash":"2194740968305097627","title":"Mitotic spindle assembly and kinetochore dynamics","description":"The GO terms are dominated by mitotic spindle assembly, spindle orientation, kinetochore-microtubule interactions, and microtubule-based process regulation, indicating a cohesive role in mitosis and spindle dynamics.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0021685","count":1},{"id":"GO:0033624","count":1},{"id":"GO:0099607","count":1},{"id":"GO:0031534","count":1}]},{"hash":"795005081365964512","title":"DNA replication and chromosome maintenance","description":"This cluster's GO terms cluster around DNA metabolism and chromosome dynamics, including replication, repair, and segregation, suggesting a shared role in maintaining genome integrity. A few translation-related terms appear, likely noise or dual-function, but the dominant pattern is DNA replication/repair and chromosomal processes.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1990090","count":1},{"id":"GO:0032543","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0000819","count":1},{"id":"GO:0006307","count":1}]},{"hash":"1840420180059422541","title":"Negative regulation of inflammatory signaling","description":"This cluster is characterized by GO terms that describe negative regulation of major inflammatory pathways (NF-kappaB, ERK1/2/JNK) and immune cytokine signaling (MCP-1 production), plus glucocorticoid response, suggesting a theme of dampening inflammation and modulating immune responses.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035726","count":1},{"id":"GO:0009735","count":1},{"id":"GO:0043124","count":1},{"id":"GO:0071385","count":1},{"id":"GO:0070373","count":1}]},{"hash":"124969380047587309","title":"RNA Processing and Splicing Regulation","description":"The terms cluster around post-transcriptional RNA processing: spliceosome-regulated splicing (both positive and negative), regulation of polyadenylation, mRNA modification/stabilization, mRNA processing via the small-subunit processome, and translation reinitiation. These cohesive features point to a core function in RNA maturation and regulation of gene expression, with blastocyst formation being a less central, context-specific signal.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0031047","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0048255","count":2}]},{"hash":"1432625239398553186","title":"Immune Signaling and Cytokine Regulation","description":"The top GO terms cluster around immune activation and signaling, including TLR9 signaling, B cell proliferation, and IL-6 production, along with NF-kappaB regulation. There are also links to actin cytoskeleton dynamics and mitochondrial fission that often accompany immune cell activation and movement. A couple of RNA export terms appear, which may be less directly related or reflect broader cellular processes. Overall, the theme is immune signaling and cytokine regulation, with some ancillary cellular processes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016525","count":4},{"id":"GO:0002322","count":4},{"id":"GO:0006409","count":3},{"id":"GO:0043124","count":3},{"id":"GO:0051638","count":3}]},{"hash":"2194694410996645506","title":"Ubiquitin-dependent protein degradation","description":"The top terms are centered on ubiquitination and proteolysis (ubiquitin-dependent protein catabolic process and protein polyubiquitination), pointing to the ubiquitin\u2013proteasome system as the core function. Supporting terms include autophagy and regulation of immune signaling, suggesting this cluster broadly involves protein turnover and modulation of immune pathways via ubiquitin tagging. This makes the label representative and specific to the cluster\u2019s main theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0002635","count":1},{"id":"GO:0045623","count":1},{"id":"GO:0006914","count":1}]},{"hash":"1674189122917686338","title":"Cartilage development and chondrocyte differentiation","description":"Based on the GO terms, the cluster is enriched for cartilage-related processes: chondrocyte differentiation and proliferation, proteoglycan biosynthesis, tissue regeneration, and neural crest\u2013associated differentiation. While there are a couple of general cellular processes (snRNA processing, rRNA transcription), the dominant theme centers on cartilage formation, maintenance, and repair. This suggests the cluster represents cartilage development and regeneration programs rather than a broad set of unrelated functions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016180","count":1},{"id":"GO:0010212","count":1},{"id":"GO:0035988","count":1},{"id":"GO:1902730","count":1},{"id":"GO:1902732","count":1}]},{"hash":"854192156568705188","title":"Mitochondrial energy production and translation","description":"The cluster is dominated by mitochondrial-related processes: translation and mitochondrial electron transport/ATP synthesis, including complex IV assembly and oxidative phosphorylation regulation. While there are a few terms linked to cell cycle and oocyte development, the strongest and most frequent GO terms point to mitochondrial energy metabolism, suggesting the proteins are centered on mitochondrial function rather than cytosolic processes. Confidence: Medium","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006123","count":1},{"id":"GO:0042776","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0008284","count":1}]},{"hash":"1413608307052716373","title":"Mitochondrial translation and tRNA charging","description":"The top GO terms are dominated by tRNA aminoacylation (seryl, prolyl, threonyl, glycyl) and related translation processes, with several mitochondrial-specific variants, indicating a cluster of proteins involved in mitochondrial protein synthesis and tRNA charging. Although a couple of terms are unusual or obsolete (e.g., left/right pattern formation, diadenosine tetraphosphate biosynthesis), the dominant theme ties to mitochondrial translation machinery and aminoacylation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097056","count":1},{"id":"GO:0070158","count":1},{"id":"GO:0006433","count":1},{"id":"GO:0016260","count":1},{"id":"GO:0070159","count":1}]},{"hash":"2047451839389643068","title":"Chromatin remodeling and transcription regulation","description":"Based on the top GO terms, this cluster centers on chromatin organization, nucleosome assembly, chromatin remodeling, and DNA-templated transcription, suggesting a group of proteins involved in regulating chromatin structure and transcription initiation. A few terms (e.g., collagen catabolic process) appear unrelated noise, but the dominant themes point to chromatin regulation and transcription. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006338","count":1},{"id":"GO:0034724","count":1},{"id":"GO:1990141","count":1},{"id":"GO:0030466","count":1}]},{"hash":"392719825733464993","title":"Neuronal Synaptic Signaling and Plasticity","description":"This cluster centers on neuronal communication and synaptic regulation, with terms for neurotransmitter secretion, synaptic vesicle exocytosis, long-term potentiation, and memory. Calcium ion signaling and phosphatidylinositol-mediated signaling tie these processes to synaptic plasticity, supporting a cohesive neuronal signaling theme. Some terms (VEGF signaling, plant hormone pathways) may reflect cross-annotation noise, but the core pattern is clearly neuronal synaptic function.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0036324","count":3},{"id":"GO:0071277","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0007269","count":3},{"id":"GO:0043065","count":3}]},{"hash":"2262624910176807727","title":"Regulators of cell signaling and survival","description":"GO terms in this cluster predominantly describe regulatory roles across signaling pathways, including necroptosis and apoptosis, transcription regulation, ubiquitination, and synaptic localization. The common theme is modulation of signaling and cell fate decisions rather than core enzymatic activities, justifying a label focused on regulatory functions in signaling and survival.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":2},{"id":"GO:0010835","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0060544","count":1}]},{"hash":"1493052430017041397","title":"Insulin signaling\u2013driven actin remodeling and cell polarity","description":"The top GO terms converge on insulin receptor signaling alongside actin cytoskeleton dynamics (actin filament bundle assembly, lamellipodium assembly), cell migration, and establishment of epithelial cell polarity, indicating a cohesive module where insulin signaling shapes cytoskeletal remodeling and polarity. Some terms are ancillary or obsolete, but the core theme is clear.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0090162","count":3},{"id":"GO:2001275","count":2}]},{"hash":"1164935129471429779","title":"Inflammatory signaling and mechanotransduction","description":"This cluster centers on inflammatory response, cellular response to mechanical stimulus, JNK cascade regulation, and NF-kappaB signaling, with ties to LPS signaling and wound healing. The shared GO terms point to proteins involved in inflammation, stress-activated signaling, and mechanotransduction that influence cell movement and survival, supporting a cohesive theme of inflammatory signaling coupled with mechanical stress responses.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0046330","count":3},{"id":"GO:0097284","count":3},{"id":"GO:0031663","count":3}]},{"hash":"2217080841061344625","title":"Vesicle trafficking and secretory transport","description":"The top GO terms cluster around intracellular vesicle movement and membrane fusion across compartments (ER-Golgi, Golgi to plasma membrane, endosome to Golgi) as well as secretory events like neutrophil degranulation and exocytic insertion of receptors. This pattern points to proteins functioning in the secretory pathway and vesicle trafficking rather than a single isolated process.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":1},{"id":"GO:0098967","count":1},{"id":"GO:0042147","count":1},{"id":"GO:0016240","count":1},{"id":"GO:0042144","count":1}]},{"hash":"847060759651705096","title":"Adhesion and epidermal development","description":"The cluster is driven by cell adhesion\u2013related terms (cell adhesion, integrin biosynthetic process) and skin/cuticle\u2013related morphogenesis terms (skin morphogenesis, cuticle development), suggesting a group of proteins involved in cell\u2013matrix adhesion and epidermal/structural tissue formation. Other terms present (signaling, ion-channel regulation, heat response, hormonal secretion) are less central to this core theme, so the main signal is adhesion and epidermal development.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0048015","count":1},{"id":"GO:2001259","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0048266","count":1}]},{"hash":"1386673565856836784","title":"Neural Synapse Assembly and Adhesion","description":"The top GO terms are dominated by synapse assembly, nervous system development, and cell\u2013cell adhesion, suggesting a cluster of proteins involved in neuronal connectivity and adhesion processes. Although there are a few terms related to immune activity and bone ossification, the strongest signals cluster around synaptic formation and neural development, with adhesion mediating cell interactions. This points to a cohesive theme of neural connectivity through synapse assembly and adhesion rather than a single unrelated process.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":2},{"id":"GO:0006910","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0051965","count":2}]},{"hash":"2129096053730799743","title":"Unknown","description":"The GO terms span diverse areas: developmental processes (multicellular development, skeletal morphogenesis, retina development), cytoskeletal regulation (actin depolymerization), RNA processing (splicing), translation control (frameshifting regulation), nuclear transport (nuclear pore localization), and sensory functions (taste). There is no single cohesive function or theme linking these proteins, and there are no network edges to reinforce a shared pathway. Therefore, a specific, representative label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007584","count":4},{"id":"GO:0048705","count":4},{"id":"GO:0030042","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0050909","count":4}]},{"hash":"933628602334234733","title":"mRNA Processing and Spliceosome Regulation","description":"The GO terms cluster around post-transcriptional control: splicing regulation (via spliceosome, negative regulation), mRNA modification and stabilization, polyadenylation-related terms, translation reinitiation, and the small-subunit processome, pointing to a module of RNA processing and ribosome biogenesis rather than a single pathway; the \"blastocyst formation\" term appears incidental.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0031047","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0048255","count":2}]},{"hash":"1409758299059654913","title":"RNA Pol II transcription machinery","description":"The GO terms are dominated by RNA polymerase II\u2013related processes: promoter clearance, initiation, start-site selection, elongation, capping, and transcription of snRNA, all of which point to the core transcription machinery and early RNA processing by Pol II. This cohesive theme justifies labeling as Pol II transcription machinery.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001111","count":1},{"id":"GO:0050434","count":1},{"id":"GO:0010467","count":1},{"id":"GO:0080163","count":1},{"id":"GO:0001174","count":1}]},{"hash":"1142981580350868005","title":"Ribosome biogenesis and LSU export","description":"The top GO terms cluster around the large subunit (LSU) of the ribosome: assembly of the LSU, maturation of LSU rRNA, and export of the LSU from the nucleus, plus preribosome assembly. Additional terms about intracellular transport and nuclear import support a nuclear\u2013cytoplasmic trafficking theme typical of ribosome biogenesis. This coherently ties the proteins to the process of assembling and exporting the LSU. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042144","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0000027","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0000055","count":1}]},{"hash":"2015037554360078351","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048024","count":1},{"id":"GO:0033129","count":1},{"id":"GO:0090503","count":1},{"id":"GO:1905053","count":1},{"id":"GO:0042254","count":1}]},{"hash":"949368166530021233","title":"Developmental and sensory organ morphogenesis","description":"Based on GO terms, there is a pattern of developmental processes: multicellular organism development, skeletal system morphogenesis, retina development, and sensory perception of taste. This suggests these proteins participate in shaping tissues and sensory organs. The other terms (actin filament dynamics, splicing, nuclear pore localization, and translational regulation) indicate shared cellular processes that support development, so the cluster centers on developmental/sensory morphogenesis rather than a single specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0050909","count":2}]},{"hash":"88949967496072689","title":"Unknown","description":"The GO terms are heterogeneous, including aromatic compound catabolism (toluene, carbazole, 3-phenylpropionate), photosynthesis and nonphotochemical quenching, proton transmembrane transport, and developmental terms (pituitary gland development, male gonad development). There is no single cohesive function tying these proteins together, suggesting annotation noise or disparate roles, so there is no clear, shared theme to name the cluster. ","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0046381","count":2},{"id":"GO:0019380","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0021983","count":2}]},{"hash":"1771244203696010120","title":"Unknown","description":"The GO terms include developmental processes (roof of mouth development, left/right pattern formation, endocrine system and pancreatic cell development) but also unrelated areas like oxidative stress response, vitamin D regulation, RNA splicing and transcription regulation, DNA repair, and ribosome export. The terms do not cohere into a single interpretable functional theme for this cluster.","confidence":"","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0060972","count":3},{"id":"GO:0042542","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0035270","count":3}]},{"hash":"2078516198477570745","title":"RNA and protein methylation enzymes","description":"The top GO terms are dominated by methylation processes: rRNA methylation and various peptidyl- methylation activities (N-terminal glycine methylation, peptidyl-lysine trimethylation/dimethylation), with an additional link to rDNA heterochromatin formation, suggesting a cluster of methyltransferases acting on RNA and proteins, including chromatin-related methylation.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":4},{"id":"GO:0018013","count":3},{"id":"GO:0018023","count":3},{"id":"GO:0000183","count":3},{"id":"GO:0018027","count":3}]},{"hash":"1065555238506747914","title":"Nucleotide metabolism and RNA editing","description":"The cluster\u2019s GO terms cluster around nucleotide metabolism and RNA modification: cytidine/cytosine metabolism, deoxycytidine catabolism, UMP salvage, and uridine biosynthesis, plus tRNA wobble adenosine to inosine editing. While there are a few unrelated terms (e.g., riboflavin biosynthesis, multicellular development), the strongest shared function across terms is nucleotide turnover and RNA editing/modification, which supports a cohesive label focused on nucleotide metabolism and RNA modification.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":1},{"id":"GO:0006147","count":1},{"id":"GO:0009972","count":1},{"id":"GO:0009231","count":1},{"id":"GO:0002100","count":1}]},{"hash":"206619938140493766","title":"Neurodevelopment and angiogenesis","description":"The cluster\u2019s top GO terms cluster around nervous system development (peripheral nervous system development, myelination, embryonic morphogenesis) and angiogenesis, with supporting roles for cell adhesion and substrate-dependent migration; together these indicate a coordinated developmental program governing neural and vascular formation, with one outlier term on T cell costimulation.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":5},{"id":"GO:1904237","count":5},{"id":"GO:0001525","count":5},{"id":"GO:2000525","count":5},{"id":"GO:0007422","count":5}]},{"hash":"364611425667936561","title":"Glycolysis and TCA cycle metabolism","description":"The cluster's top GO terms are dominated by glycolytic process and the tricarboxylic acid cycle, with regulation of pyruvate decarboxylation to acetyl-CoA, pointing to core cellular energy production pathways. The neuronal development terms are less central to the main theme but may reflect context in neural tissues.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0002098","count":2},{"id":"GO:0021695","count":2}]},{"hash":"683527451863991474","title":"Inflammatory signaling and actin remodeling","description":"The top GO terms point to cellular responses to inflammatory cues (interleukin-1, TNF) and oxidative stress (hydrogen peroxide), combined with multiple actin cytoskeleton\u2013related processes (debranching, cortical actin localization, dendritic spine morphogenesis). This suggests a cohesive theme where inflammatory signaling is linked to remodeling of the actin cytoskeleton and associated cell shape or signaling changes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":3},{"id":"GO:0070301","count":3},{"id":"GO:0071356","count":3},{"id":"GO:0061001","count":2},{"id":"GO:0042989","count":2}]},{"hash":"662469258058005822","title":"Cell cycle checkpoints in mitosis and meiosis","description":"The cluster\u2019s GO terms are dominated by mitotic and meiotic checkpoint signaling, including mitotic cell cycle, spindle assembly checkpoint, DNA integrity checkpoint signaling, and meiosis-specific checkpoint terms, suggesting a cohesive role in regulating chromosome segregation across both mitotic and meiotic contexts, despite the lack of observed edges.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038180","count":1},{"id":"GO:0010944","count":1},{"id":"GO:1990492","count":1},{"id":"GO:0090267","count":1},{"id":"GO:0000278","count":1}]},{"hash":"1027570405449000738","title":"Neuronal signaling and axon guidance","description":"This cluster centers on neural signaling terms: touch perception, excitatory postsynaptic potential, axon guidance, and regulation of long-term synaptic plasticity, indicating proteins involved in synaptic communication and neural connectivity; other terms are minor or obsolete. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050975","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0048169","count":2},{"id":"GO:1904231","count":1}]},{"hash":"1013904210412986278","title":"Neural development and innate immune signaling","description":"Top GO terms indicate a blend of neural development processes (myelination; corpus callosum development; axon extension; synapse assembly; collagen fibril organization) with innate immune signaling (TLR9 signaling; cellular response to lipopolysaccharide; innate immune response). This overlap suggests the proteins may participate in CNS development where immune pathways influence glial activity and wiring, rather than a single isolated function. Therefore, the cluster can be described as Neural development and innate immune signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034162","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0032474","count":3},{"id":"GO:0030199","count":3}]},{"hash":"1112158944125665051","title":"Neural differentiation and synaptic connectivity","description":"Dominant GO terms describe neuron differentiation (pyramidal neuron differentiation), synapse assembly, axon guidance, and cell adhesion, pointing to neural development and formation of synaptic connections. Melanocyte-related terms likely reflect shared neural crest lineage, while immune-related terms (complement activation, TNF/STAT signaling) appear sparsely and do not define the core function. Thus the label captures the main theme of neural development and synaptic connectivity.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0033564","count":3},{"id":"GO:0021859","count":3}]},{"hash":"768355237296827778","title":"Chromatin regulation and cell cycle control","description":"The GO terms cluster around regulatory processes affecting transcription and chromatin states (positive regulation of mediator complex assembly, positive regulation of chromatin binding) and cell proliferation (negative regulation of fibroblast proliferation, regulation of cell cycle). While other terms touch on development and immune responses, the strongest signal is regulation of transcriptional machinery and cell cycle, suggesting this theme best represents the group.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":2},{"id":"GO:0071158","count":1},{"id":"GO:0035563","count":1},{"id":"GO:0002805","count":1},{"id":"GO:2001178","count":1}]},{"hash":"51562497301077543","title":"Synaptic signaling and postsynaptic organization","description":"The terms cluster around neurotransmitter receptor signaling (acetylcholine, GABA, serotonin), regulation of nerve impulse transmission, and postsynaptic membrane organization, with associated neural behaviors (startle, conditioned taste aversion, walking) and even nerve development. This points to a cohesive theme of synaptic communication and postsynaptic structure linking to neural behavior.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051970","count":4},{"id":"GO:0001661","count":4},{"id":"GO:0095500","count":4},{"id":"GO:0001964","count":4},{"id":"GO:0007628","count":4}]},{"hash":"1225658926818906465","title":"Unknown","description":"The top GO terms cover GPCR signaling, energy metabolism (electron transport chain), vascular regulation (blood pressure, vasopressin), Rho signaling, photoreceptor maintenance, and various immune/cell proliferation processes. There is no single cohesive function tying all these terms together, so a representative, specific label cannot be determined.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":4},{"id":"GO:0022900","count":4},{"id":"GO:0045777","count":4},{"id":"GO:0035025","count":4},{"id":"GO:0045494","count":3}]},{"hash":"1169281165359013335","title":"Unknown","description":"The top GO terms cover a wide range of unrelated physiological areas\u2014from sensory perception and temperature response to cardiac conduction, immune regulation, and development\u2014without a single cohesive biological process linking them. Because there\u2019s no clear shared function across the proteins, a specific, representative label cannot be justified.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":5},{"id":"GO:0097623","count":5},{"id":"GO:0050968","count":5},{"id":"GO:0021750","count":5},{"id":"GO:0002724","count":5}]},{"hash":"2012442391620350120","title":"Immune and inflammatory signaling regulators","description":"The terms cluster around immune activation and signaling modulation, including regulation of IL-1\u03b2 production, dendritic cell differentiation, and sensitization, as well as GPCR/cAMP/PKA signaling (adenylate cyclase-inhibiting opioid receptor pathway). Some items (blood pressure vasopressin regulation, photoreceptor maintenance, temperature response) are less central but reflect broader homeostatic signaling. Overall, this label captures the dominant theme of immune/inflammatory signaling control.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":3},{"id":"GO:0001992","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0032651","count":3},{"id":"GO:0097029","count":3}]},{"hash":"1470594354669202394","title":"Antiviral and ER Stress Response","description":"Top GO terms indicate defense response to virus and cellular response to type I interferon, pointing to antiviral signaling. Other terms reflect ER stress\u2013related regulation of translation and protein targeting to membranes, along with oxidative and metal ion stress responses. Together these terms suggest a cluster of proteins involved in antiviral defense and broader cellular stress responses rather than a single, narrow pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0071357","count":1},{"id":"GO:0010288","count":1},{"id":"GO:1900035","count":1}]},{"hash":"599289619620902560","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0006458","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0046825","count":2},{"id":"GO:1901621","count":2}]},{"hash":"1628749142659273212","title":"Neuroimmune development and signaling","description":"The terms cluster around neural development and connectivity (retina development, synapse assembly) and immune/inflammatory responses (lipopolysaccharide response, IL-4 production, fibrinogen regulation), plus general signaling cues (cellular response to ATP). This suggests a cohesive theme of neuroimmune communication during development, even though a couple of terms are more peripheral metabolic processes. Confidence: Medium","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0032496","count":3},{"id":"GO:0042572","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0061074","count":2}]},{"hash":"1219653332351685700","title":"Morphogenesis and actin cytoskeleton remodeling","description":"This cluster mixes developmental morphogenesis terms across organisms (haltere, plant ovule, metanephric kidney morphogenesis) with actin cytoskeleton dynamics (lamellipodium assembly, actin filament depolymerization). The common thread appears to be shaping cell form through cytoskeletal remodeling and morphogenesis, though one term about transcription is less tightly connected.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":5},{"id":"GO:0048735","count":5},{"id":"GO:0042789","count":5},{"id":"GO:0090334","count":5},{"id":"GO:0008588","count":5}]},{"hash":"133870247217907383","title":"Presynaptic vesicle clustering and exocytosis","description":"The top GO terms are dominated by synaptic vesicle clustering, synaptic vesicle exocytosis, receptor internalization at the synapse, and cytoskeletal organization at the active zone, all signaling presynaptic vesicle cycling and maturation. While a few terms relate to broader responses (glucocorticoid, alkaloid) or other processes, the predominant theme ties to presynaptic structure and vesicle trafficking at the synapse. This makes a presynaptic vesicle docking/exocytosis label most representative.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":2},{"id":"GO:1902474","count":1},{"id":"GO:0097091","count":1},{"id":"GO:2000302","count":1},{"id":"GO:0051384","count":1}]},{"hash":"76406261900745324","title":"T cell differentiation and type 2 immune response","description":"This cluster centers on immune system functions, with terms for pro-T cell differentiation, memory T cell differentiation, and type 2 immune responses, plus regulation of mast cell cytokine production and IgE isotype switching, suggesting a theme around adaptive Th/innate immune interactions. A few unrelated terms (e.g., ubiquitin-dependent catabolic process, distal tubule morphogenesis) may reflect background processes or annotation noise. Overall, the immune-related terms tie together into a coherent cluster theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0048294","count":3},{"id":"GO:2000176","count":3},{"id":"GO:0042092","count":3},{"id":"GO:0009958","count":3}]},{"hash":"541532939225582795","title":"Developmental morphogenesis and actin remodeling","description":"The enriched terms point to developmental processes (multicellular organism development, skeletal system morphogenesis, retina development) and cytoskeletal regulation (actin filament depolymerization, GTPase activity regulation), suggesting a theme of morphogenesis linked to actin dynamics, despite less coherent terms like aging or taste perception. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007584","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0030042","count":2}]},{"hash":"578360517303138317","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:1902474","count":1},{"id":"GO:1902354","count":1},{"id":"GO:0051932","count":1},{"id":"GO:0097150","count":1}]},{"hash":"367347385421517506","title":"ER-Golgi and Endosomal Vesicle Trafficking","description":"The cluster is dominated by GO terms describing vesicle movement between the endoplasmic reticulum, Golgi, endosomes, and related vesicle processes (ER-to-Golgi, Golgi-to-ER, endosome-to-Golgi, endosome-to-melanosome, endocytosis, and vacuolar targeting). This suggests a cohesive function in intracellular vesicle transport and protein sorting, despite a couple of outliers. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0035646","count":3},{"id":"GO:0006897","count":2},{"id":"GO:0006623","count":2}]},{"hash":"142676805247131021","title":"Translation Initiation and Proteostasis","description":"This cluster shows strong signals for translation initiation and assembly of initiation complexes (formation of translation preinitiation complex; cytoplasmic initiation complex; EIF3 complex assembly) alongside protein turnover processes (proteasome assembly; deneddylation). These terms point to a functional group involved in initiating protein synthesis and maintaining protein quality, hence the label. Occasional terms like meiosis I or neuron differentiation appear but are not central to the main theme.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000338","count":3},{"id":"GO:0043248","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0070196","count":1}]},{"hash":"2113474527420087395","title":"Ubiquitin-Dependent Protein Turnover & Chromatin Regulation","description":"This cluster is driven by ubiquitin-related protein catabolism (ubiquitin-dependent protein catabolic process, actin ubiquitination) and chromatin dynamics (histone catabolic process, PML body organization). It also includes antiviral/immune signaling roles (negative regulation of viral transcription, RIG-I pathway regulation, T cell proliferation), suggesting a cohesive theme where ubiquitin-mediated turnover influences chromatin state and antiviral responses.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0042098","count":3},{"id":"GO:0045869","count":3},{"id":"GO:0036205","count":3},{"id":"GO:0030578","count":3}]},{"hash":"19228094660909842","title":"TNF/NF-\u03baB signaling and ubiquitination","description":"The terms cluster around NF-\u03baB pathway activation in response to TNF, with key roles for I\u03baB phosphorylation, NIK activation, and ubiquitination (K63-linked, autoubiquitination) within an innate immune context. This supports a cohesive label focused on TNF/NF-\u03baB signaling and ubiquitination.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0090073","count":3},{"id":"GO:0051865","count":3},{"id":"GO:1903721","count":3}]},{"hash":"620684156536877001","title":"Autophagy and phosphatase regulation","description":"GO terms point to regulatory roles in phosphatase activity, autophagy, and metabolism, with accompanying hints of signaling control and development. The recurring theme is cellular signaling and stress-response regulation rather than a single enzymatic function, suggesting a broad regulatory cluster rather than a specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":4},{"id":"GO:0001519","count":4},{"id":"GO:0032515","count":4},{"id":"GO:0032897","count":4},{"id":"GO:1901253","count":4}]},{"hash":"1047375836701528259","title":"Neuro-Muscular Development and Immune Signaling","description":"This cluster links nervous system and skeletal muscle development with immune signaling pathways (B cell receptor and interleukin-1 signaling) and apoptosis-related terms, indicating a broad developmental/signaling role across tissues rather than a single pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0006915","count":2}]},{"hash":"45138519972103819","title":"Regulated signaling and immune defense responses","description":"This cluster is enriched for terms related to signaling pathway regulation (GPCR signaling, steroid receptor assembly), immune/defense modulation (interferon response, negative regulation of defense against virus), protein modification (K11-linked ubiquitination), and stress responses (metal ion response). The common theme is broad regulation of signaling and defense/stress-related processes across different systems, rather than a single precise pathway, so the label reflects a general regulatory role in signaling and immune/stress responses.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0071357","count":5},{"id":"GO:0008277","count":5},{"id":"GO:0006463","count":5},{"id":"GO:0050689","count":5},{"id":"GO:0007091","count":5}]},{"hash":"1589123832788604612","title":"Vascular adhesion and angiogenesis regulation","description":"This cluster is enriched for terms related to cell adhesion (integrin biosynthesis, adhesion molecule production, cell-cell adhesion), and angiogenesis (sprouting angiogenesis regulation, lymphangiogenesis), along with coagulation and signaling modulation (ERK cascade). Together, these suggest a cohesive role in vascular adhesion and angiogenic signaling rather than unrelated processes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0045112","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0070373","count":2}]},{"hash":"1767382174468625735","title":"Lipid metabolism and signaling","description":"The top GO terms are dominated by lipid-related processes: monoacylglycerol and triglyceride catabolism, phosphatidylserine catabolism, and arachidonate metabolism, with a note of endocannabinoid signaling (a lipid-derived pathway). While there are some peripheral terms (UV-B response, plant defense-related camalexin biosynthesis), the strongest recurring theme across the terms is lipid turnover and lipid-mediated signaling, making this the most representative label given the data. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019369","count":1},{"id":"GO:0098921","count":1},{"id":"GO:0071327","count":1},{"id":"GO:1901183","count":1},{"id":"GO:0071493","count":1}]},{"hash":"1401097474452309498","title":"Mitotic spindle organization and metaphase alignment","description":"The top GO terms are dominated by mitosis- and microtubule-related processes: regulation of mitotic spindle organization, mitotic metaphase chromosome alignment, positive regulation of microtubule polymerization, and microtubule bundle formation, with a signal also pointing to CDK activity. Together these indicate a cluster focused on spindle dynamics and chromosome segregation during cell division. Some peripheral terms like cellular response to cycloheximide or interleukin-15 appear as noise rather than core themes. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071409","count":1},{"id":"GO:0070672","count":1},{"id":"GO:0007080","count":1},{"id":"GO:0060236","count":1},{"id":"GO:0030308","count":1}]},{"hash":"229073552721368749","title":"Neuroendocrine-Immune Signaling","description":"These proteins converge on signaling and regulatory processes spanning neuroendocrine control of blood pressure, immune cell development and cytokine production, and GPCR/cAMP\u2013mediated pathways. The terms include vasopressin-regulated blood pressure, IL-1\u03b2 production, dendritic cell differentiation, cAMP-dependent signaling, and opioid receptor\u2013related pathways, with additional links to photoreceptor maintenance and temperature response as tissues where these signaling motifs operate. Overall, the cluster reflects cross-tissue signaling regulation rather than a single pathway.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":5},{"id":"GO:0001992","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0032651","count":5},{"id":"GO:0097029","count":5}]},{"hash":"1902264708369843086","title":"RNA and protein methylation","description":"This cluster is dominated by GO terms for methylation, including N-terminal peptidyl-serine methylation, tRNA methylation, rRNA modification, and RNA guanine-N7 methylation, as well as histone methylation. The recurring theme is methyltransferase-mediated modification across RNA and proteins, making \"RNA and protein methylation\" a concise, representative label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035573","count":2},{"id":"GO:0032259","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0035572","count":2},{"id":"GO:0043985","count":2}]},{"hash":"460124563220737720","title":"Neuronal adhesion and synapse development","description":"The top GO terms cluster around cell-cell adhesion (homophilic/heterophilic) and synapse biology: nervous system development, positive regulation of synapse assembly, paranodal junction assembly, and GABAergic synaptic transmission. Together these point to proteins that mediate neuronal contacts and organize synapses, possibly contributing to inner-ear labyrinthine development and related neural pathways. The ossification term is less central but may reflect shared adhesion molecules present in multiple tissues.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0051965","count":2}]},{"hash":"2275506140605555026","title":"Collagen-Integrin Signaling and Skin Development","description":"The cluster is characterized by GO terms tied to extracellular matrix interactions and cell adhesion, especially collagen-activated signaling, integrin biosynthesis, and skin morphogenesis. This suggests the proteins function together in ECM-collagen adhesion and epidermal development, with a few xenobiotic response terms likely incidental noise.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:1902168","count":1},{"id":"GO:1904643","count":1},{"id":"GO:0046689","count":1},{"id":"GO:2000860","count":1}]},{"hash":"2135956495205403246","title":"Development and Morphogenesis Signaling","description":"The top GO terms cluster around developmental processes and tissue remodeling (neural crest formation, EMT, angiogenesis, metanephric development) alongside regulatory activities (peptidyl-threonine phosphorylation, glucocorticoid response, nuclear import). The set doesn\u2019t map to a single cohesive pathway but points to regulation of development and morphogenesis, so a developmental/morphogenesis label best captures the common theme, albeit broadly.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008284","count":5},{"id":"GO:0007613","count":5},{"id":"GO:0030437","count":5},{"id":"GO:0006607","count":5},{"id":"GO:0014029","count":5}]},{"hash":"449382392253432839","title":"Growth factor signaling and angiogenesis","description":"Protein set shows enrichment for tyrosine phosphorylation signaling (peptidyl-tyrosine autophosphorylation, STAT phosphorylation) and multiple growth-factor pathways (VEGF/PDGF, erythropoietin) with angiogenesis as a key GO term, plus related signaling (Wnt, IL-2). This points to a cohesive theme of growth-factor\u2013driven signaling promoting cell proliferation and angiogenesis.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097326","count":2},{"id":"GO:1900086","count":2},{"id":"GO:0042523","count":2},{"id":"GO:0038162","count":2},{"id":"GO:0001525","count":2}]},{"hash":"1338668338019411351","title":"Inflammation with inflammasome activation and leukocyte chemotaxis","description":"The proteins are enriched for NF-\u03baB signaling (I-kappaB phosphorylation), NLRP3 inflammasome activation, antiviral defense, and IL-1 production, paired with chemotaxis of macrophages, neutrophils, and lymphocytes and acute-phase responses. This points to a cohesive inflammatory program coordinating cytokine signaling with leukocyte recruitment.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007252","count":2},{"id":"GO:1900227","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0048247","count":1},{"id":"GO:0006953","count":1}]},{"hash":"2108139095971258105","title":"Neural Development and Growth Factor Signaling","description":"This cluster centers on neuronal development and axon guidance, with signals from growth factors (VEGF, HGF) activating ERK/MAPK pathways to drive neural differentiation and pathfinding (retinal ganglion and commissural axon guidance, neural crest migration). The GO terms suggest activity-dependent processes (environmental enrichment) and MAPK signaling as core mechanisms. While a couple of terms are less directly related (keratinocyte proliferation), the dominant theme ties neural development to growth-factor\u2013mediated signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090648","count":2},{"id":"GO:0048010","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0035729","count":2}]},{"hash":"610261150606084360","title":"Ubiquitin-Dependent Protein Degradation","description":"The dominant GO terms are about ubiquitination and proteasomal turnover (K48-linked ubiquitination, autoubiquitination, and ubiquitin-dependent protein catabolic process), indicating the cluster centers on tagging and degrading proteins. A few minor terms appear unrelated or broad, but the core signal is clear.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070936","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0061014","count":1},{"id":"GO:1904646","count":1}]},{"hash":"1112900160948495275","title":"Tooth development and mineralization","description":"The top GO terms cluster around odontogenesis and mineralization (odontoblast differentiation, dentinogenesis, enamel mineralization, tooth eruption) with related bone mineralization processes, indicating proteins functioning in dental tissue formation and mineral deposition.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045669","count":1},{"id":"GO:0097187","count":1},{"id":"GO:0070166","count":1},{"id":"GO:0071895","count":1},{"id":"GO:1903955","count":1}]},{"hash":"137700135924238219","title":"Vacuolar trafficking and autophagy","description":"The cluster\u2019s GO annotations are dominated by vacuolar-related processes (vacuolar transport, vacuole fusion, and microautophagy), indicating a shared role in intracellular membrane dynamics and degradation pathways. Although a few terms pertain to cell polarity or non-vacuolar processes, the strongest signal points to vesicle trafficking to/from the vacuole and autophagic mechanisms. Confidence in this label is moderate due to some cross-species or broad annotations present among the terms.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":1},{"id":"GO:0006799","count":1},{"id":"GO:2000769","count":1},{"id":"GO:0048016","count":1},{"id":"GO:0016237","count":1}]},{"hash":"649484061839267149","title":"Steroid Hormone and Vitamin D Metabolism","description":"The top GO terms center on aldosterone biosynthesis and its regulation of blood volume, along with vitamin D\u2013related responses and metabolism, plus mammary gland development\u2014all hallmarks of endocrine steroid/ secosteroid pathways and hormone-regulated tissue function. Peripheral terms like oxylipin biosynthesis and macrophage chemotaxis may reflect broader signaling, but the core theme is steroid hormone and vitamin D metabolism.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031408","count":3},{"id":"GO:0033076","count":2},{"id":"GO:0010164","count":2},{"id":"GO:0032342","count":2},{"id":"GO:0002017","count":2}]},{"hash":"1128988420359199024","title":"Neuronal microtubule dynamics and mechanosensation","description":"This cluster is dominated by GO terms related to microtubule organization, nucleation, and mitotic spindle assembly, alongside neuron differentiation and mechanosensory/touch signaling. The common thread appears to be neuronal cytoskeletal dynamics and related mechanosensory functions, with some unrelated terms present that may reflect broader interactions or annotation noise. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045347","count":2},{"id":"GO:1904780","count":2},{"id":"GO:0000289","count":2},{"id":"GO:0044829","count":2},{"id":"GO:1905792","count":1}]},{"hash":"101576928626386861","title":"Innate Immune Activation and Phagocytosis","description":"The top GO terms point to immune signaling and phagocytic activity (innate immune response-activating signaling pathway, positive regulation of phagocytosis) and vesicle trafficking (synaptic vesicle endocytosis), suggesting the cluster centers on endocytic/immune functions. Other terms related to signaling modulation and cell spreading may reflect broader pathway involvement, but the core theme appears to be innate immune activation with endocytic/phagocytic processes.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048916","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0048387","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0090398","count":2}]},{"hash":"2041512466459544688","title":"Post-transcriptional RNA processing and splicing","description":"The Top Terms show strong enrichment for mRNA processing activities: polyadenylation regulation (even if obsolete in the dataset), mRNA modification, mRNA stabilization, and regulation of splicing via the spliceosome, plus translation reinitiation and small-subunit processome assembly. Together, these point to a cohesive function centered on RNA maturation and post-transcriptional control rather than transcriptional regulation. Blastocyst formation appears incidental, not the defining theme. ","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0031047","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0048255","count":2}]},{"hash":"875554977014151790","title":"Developmental morphogenesis and neuronal migration","description":"The GO terms point to tissue morphogenesis across organs (lymphatic vessel, metanephric tubules) and structural organization (collagen fibril), coupled with cell adhesion and differentiation (endodermal differentiation, homophilic adhesion). In parallel, neuronal context terms (tangential migration to the olfactory bulb, clustering of voltage-gated sodium channels) suggest a neuronal development theme. Taken together, the cluster seems to reflect developmental processes involving morphogenesis, cell adhesion, and neuron migration/differentiation, with kidney and vascular development represented alongside neural functions.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0036303","count":4},{"id":"GO:0072237","count":4},{"id":"GO:0072287","count":4},{"id":"GO:0006910","count":3},{"id":"GO:0045162","count":3}]},{"hash":"399071696457521124","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0046825","count":2},{"id":"GO:0034975","count":2},{"id":"GO:1901621","count":2}]},{"hash":"228313602306610052","title":"Mitotic Regulation and Microtubule Transport","description":"The cluster's terms mainly point to cell-cycle control during mitosis\u2014G2/M transcription, DNA replication initiation, and spindle checkpoint signaling\u2014and to plus-end-directed microtubule transport, suggesting a mitotic regulation theme. Peripheral terms like innate immune response and cholangiocyte proliferation are less connected and may reflect annotation noise.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090419","count":2},{"id":"GO:0090055","count":2},{"id":"GO:1905150","count":2},{"id":"GO:1903468","count":2},{"id":"GO:0009636","count":2}]},{"hash":"7323131781673284","title":"Mitotic spindle and microtubule dynamics","description":"This cluster is dominated by GO terms related to microtubule organization and spindle function, including mitotic spindle orientation, kinetochore\u2013microtubule attachments, minus-end directed microtubule movement, spindle pole separation, and chromosome alignment. While a couple terms are less directly tied (e.g., chloroplast movement, cerebellar structure), the overall signal points to proteins acting in microtubule-based mitotic/spindle dynamics. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0021685","count":2},{"id":"GO:0033624","count":2},{"id":"GO:0099607","count":2},{"id":"GO:0031534","count":2},{"id":"GO:0051296","count":2}]},{"hash":"1424193424086133169","title":"Fatty acid catabolism and quinone biosynthesis","description":"Proteins in this cluster are enriched for fatty acid beta-oxidation, valine and phenylacetate catabolism, and biosynthesis of quinones (menaquinone and phylloquinone), with lipoylation as a key related modification. Together, these terms suggest a metabolic module focused on energy production and electron carrier/cofactor biosynthesis. A few terms (e.g., antibiotic biosynthesis, peroxisome autophagy, transport) are present but less central to the core theme, so the overall label reflects the main metabolic connections.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0006574","count":3},{"id":"GO:0006635","count":3},{"id":"GO:0009234","count":3}]},{"hash":"1114320591592129285","title":"Cytoskeletal remodeling and cell migration","description":"Based on the GO terms, the cluster is driven by cytoskeletal remodeling and cell migration, including actin reorganization, cytokinesis, nuclear migration, and movement-related processes in wound healing and immune cells. Some terms related to signaling and organelle transport appear, but the strongest signal points to cytoskeletal dynamics and cell movement.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007286","count":4},{"id":"GO:0043124","count":3},{"id":"GO:1902307","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0007097","count":3}]},{"hash":"1143646714101001615","title":"Immune signaling and actin remodeling","description":"The cluster\u2019s top GO terms are dominated by immune-related processes (B cell receptor signaling, NK T cell differentiation, interleukin-4 production, interleukin-7 response), indicating these proteins participate in immune cell signaling. In addition, several terms point to actin cytoskeleton dynamics (actin filament binding, actin cytoskeleton reorganization), suggesting cytoskeletal remodeling accompanies the signaling functions. Despite a mix of sometimes obsolete terms, the collective theme is immune signaling integrated with cytoskeletal regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007118","count":3},{"id":"GO:0031532","count":2},{"id":"GO:1904531","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0032633","count":2}]},{"hash":"1235413408245589590","title":"CNS Development and Synaptogenesis","description":"The top GO terms cluster around brain and neural development, including corpus callosum development, optic nerve morphogenesis, CNS neuron axonogenesis, and regulation of synapse assembly, pointing to neural development and synaptic formation as the core theme. Some terms (heart development, ovulation cycle, LPS response) are outliers and may reflect broader or overlapping annotations, but the dominant signal is CNS development and synaptogenesis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0042698","count":2},{"id":"GO:0042517","count":2}]},{"hash":"1155210354743140037","title":"Unknown","description":"The GO terms cover a broad and unrelated set of biological processes (fungal ascospore formation, mitotic actomyosin ring assembly, locomotion, EMT, T cell homeostasis, metal response, meiotic DNA repair, DNA damage checkpoints, kinetochore localization, and NFAT signaling). There\u2019s no single, coherent theme uniting these terms for this small cluster, so a specific functional label isn\u2019t supported. ","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030437","count":4},{"id":"GO:1903501","count":4},{"id":"GO:0031987","count":4},{"id":"GO:0001837","count":4},{"id":"GO:0043029","count":4}]},{"hash":"75663657998552610","title":"Ribosome biogenesis and translational fidelity regulation","description":"This cluster centers on ribosome production and the accuracy of protein synthesis, with key terms for translation, ribosome biogenesis, and maintenance/positive regulation of translational fidelity. It also includes rRNA modification (pseudouridine synthesis) and export, plus regulatory touches on translation initiation. Additional signals like heat and antibiotic responses appear as secondary stress-related influences on the translation Machinery.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045903","count":2},{"id":"GO:1990145","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0006412","count":2}]},{"hash":"675545474824721499","title":"Protein synthesis and complex assembly","description":"Terms show translation, transcription, and protein oligomerization, suggesting the cluster centers on protein production and assembly into multiprotein complexes; ancillary metabolic/differentiation terms are less representative, so the label reflects the core function.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0051289","count":1},{"id":"GO:0043496","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0051291","count":1}]},{"hash":"1777551220781552083","title":"COPII-Mediated ER-Golgi Transport","description":"This cluster is dominated by GO terms for vesicle trafficking between the endoplasmic reticulum and Golgi, including COPII-coated vesicle budding and both directions of ER-Golgi transport, suggesting a core function in ER-Golgi trafficking. The development-related terms may reflect downstream roles during growth/development, but the strongest and most representative signal is COPII-mediated ER-Golgi transport.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1967164469701401122","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0071651","count":1},{"id":"GO:0050968","count":1}]},{"hash":"1495321803812567081","title":"Spliceosome Assembly and mRNA Processing","description":"These terms consistently point to mRNA maturation: export from the nucleus, spliceosome assembly and regulation of splicing, and subcomplexes like the processome; plus mRNA stabilization and polyadenylation. While a blastocyst formation term appears, it's likely incidental. Overall, the cluster represents components of the spliceosome and mRNA processing machinery.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":2},{"id":"GO:0001825","count":1},{"id":"GO:0031047","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0006378","count":1}]},{"hash":"1817754719377556431","title":"Unknown","description":"The GO terms span diverse contexts (protein turnover, immune signaling, muscle structure, kidney development, and even plant gravitropism) with no clear shared function connecting all proteins. There are no edges to suggest a cohesive interaction, so a single representative function cannot be inferred. Therefore, this cluster is best labeled Unknown. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0048294","count":2},{"id":"GO:2000176","count":2},{"id":"GO:0042092","count":2}]},{"hash":"2223521405408854812","title":"Vertebrate neural and organ development","description":"The terms point to embryonic formation of nervous system structures (cranial and dorsal root ganglia) and various organs (fungiform papilla, renal outer medulla), supplemented by nuclear regulation processes (NLS-bearing protein import, chromatin remodeling, transcription initiation) and cell-cycle control that accompany development. Together, they suggest a broader theme of vertebrate organ and nervous system formation.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0061198","count":2},{"id":"GO:0036023","count":2},{"id":"GO:1990791","count":2},{"id":"GO:0048496","count":2},{"id":"GO:0061550","count":2}]},{"hash":"643092647362734913","title":"TLR3/9\u2013NF-\u03baB inflammatory signaling","description":"This cluster is dominated by GO terms tied to toll-like receptor signaling (TLR3 and TLR9), CD40 signaling, and regulation of NF-\u03baB activity, all central to innate immune responses and inflammation. While a couple of terms (mitophagy, Golgi localization) are more general cellular processes, the core theme is immune signaling and inflammatory control. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001545","count":1},{"id":"GO:0050727","count":1},{"id":"GO:0051092","count":1},{"id":"GO:0043124","count":1},{"id":"GO:0034162","count":1}]},{"hash":"2067681960663800460","title":"Neuronal development and mitotic cytoskeleton","description":"This cluster centers on cytoskeletal and microtubule dynamics, with terms for neuron migration and differentiation alongside mitotic spindle assembly, cytokinesis, and spindle pole body duplication. The co-occurrence of neuronal development processes with mitotic and cytoskeletal organization suggests a shared theme of microtubule-driven dynamics governing both neuronal development and cell division, with some mechanosensory regulation terms likely reflecting cytoskeletal roles in mechanotransduction.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001764","count":4},{"id":"GO:1905792","count":3},{"id":"GO:0090529","count":3},{"id":"GO:0043093","count":3},{"id":"GO:0031122","count":3}]},{"hash":"1424301386344080075","title":"Ubiquitin-mediated regulation of T cell differentiation","description":"It combines ubiquitin-dependent protein catabolism and actin ubiquitination with immune-regulatory processes (negative regulation of T-helper cell differentiation, T cell homeostasis) and lymphocyte development signals (V(D)J recombination), suggesting a theme of ubiquitin-driven control of T-cell development and related chromatin/gene-regulatory processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0045623","count":2},{"id":"GO:0036205","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0007014","count":2}]},{"hash":"192780073943429121","title":"Immune Regulation and Autophagy","description":"These proteins show GO terms centered on regulation of T and B cell activation and germinal center processes, combined with autophagy and ubiquitin-mediated protein turnover. Additional terms touch on innate signaling (LPS), vitamin D response, and nitric-oxide synthase regulation, suggesting a cluster involved in immune cell homeostasis and linked cellular regulation. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002635","count":2},{"id":"GO:0045623","count":2},{"id":"GO:0006914","count":2},{"id":"GO:0046007","count":2},{"id":"GO:0042787","count":2}]},{"hash":"579729533662178710","title":"Unknown","description":"The Top Terms cover a wide range of unrelated processes (sensory pain detection, synaptic plasticity, spindle assembly, telomere maintenance, adipocyte differentiation, cell cycle regulation, heart morphogenesis, and hormone signaling) with no clear shared function, activity, or pathway, so there isn\u2019t a cohesive theme to label this cluster. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0007253","count":2},{"id":"GO:0032212","count":2}]},{"hash":"1896083506632531539","title":"Unknown","description":"Top terms span lipid metabolism, epidermal development, cuticle/molting biology, and neural development, with no single unifying function evident for the four proteins. The diversity of GO terms suggests either divergent roles or incidental annotations rather than a coherent shared function, so a specific representative label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014823","count":1},{"id":"GO:0003407","count":1},{"id":"GO:0042632","count":1},{"id":"GO:0018996","count":1},{"id":"GO:0043407","count":1}]},{"hash":"2206876062356468568","title":"Cardiac morphogenesis regulators","description":"This cluster's top GO terms cluster around heart development, including outflow tract morphogenesis, left ventricular morphogenesis, and regulation of atrial cardiac muscle action potential, with additional signals pointing to general transcriptional and kinase regulation. While there are broader developmental terms (bone maturation, skin development), the strongest common thread is cardiac tissue morphogenesis and its regulatory signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0071902","count":2},{"id":"GO:0007275","count":2}]},{"hash":"343531709154540348","title":"Cytoskeleton-driven cell migration and mitosis","description":"The top GO terms center on actin cytoskeleton rearrangements, nuclear migration, spindle orientation, cytokinesis, and microtubule-based transport, all of which reflect cytoskeletal remodeling that enables cell movement and cell division. Additional terms related to wound healing and cell spreading support a motility theme, while immune-related terms (macrophage differentiation, degranulation) may reflect cell-type context but do not override the core cytoskeletal/movement signal.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043124","count":4},{"id":"GO:1902307","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0007097","count":4},{"id":"GO:0044319","count":4}]},{"hash":"2092176986380691181","title":"Cofactor biosynthesis and xenobiotic response","description":"The GO terms cluster around cofactor biosynthesis (thiamine diphosphate and quinolinate) and dihydrolipoamide metabolism, which tie to energy-related cofactors, plus responses to fungicide/xenobiotic stimuli. This suggests a theme of metabolic cofactor processing coupled with detox/stress signaling, though the terms are somewhat diverse, so the connection is plausible but not airtight. ","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060992","count":4},{"id":"GO:0035563","count":4},{"id":"GO:0043046","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0046886","count":4}]},{"hash":"2287689722122014978","title":"Blood coagulation and fibrinolysis","description":"The top terms show strong emphasis on coagulation and fibrinolysis (blood coagulation, regulation/activation of plasminogen, fibrinolysis, Factor XII), with supportive immune signals (complement via lectin pathway, LPS response) and cellular remodeling (smooth muscle cell migration). This points to a thromboinflammatory/coagulation-regulation cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0044537","count":2},{"id":"GO:0030194","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0031639","count":2}]},{"hash":"1549356150540703473","title":"Multitissue development","description":"The top GO terms cluster around development across multiple tissues (multicellular organism development, cerebral cortex development, inner ear development, cartilage condensation), suggesting a general developmental program rather than a single pathway. Some terms like apoptotic process and response to toxic substance may reflect remodeling or stress during development, but the overarching theme is tissue- and organism-wide developmental regulation. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0045793","count":2}]},{"hash":"1573849835797426723","title":"Embryonic development and organogenesis","description":"This cluster shows GO terms centered on embryonic development and tissue differentiation across multiple organs: gastrulation, endoderm development, pancreas development, osteoblast development, nephrogenic mesenchyme morphogenesis, and various differentiation processes in the lung (type II pneumocytes) and general signaling regulation (BMP, Wnt). The shared theme is developmental signaling guiding organogenesis rather than a single tissue-specific function. The lone antibiotic response term is likely an annotation artifact. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001702","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0031016","count":1},{"id":"GO:0030514","count":1},{"id":"GO:0002076","count":1}]},{"hash":"1963673073416676360","title":"Cardiovascular and neural development","description":"The GO terms show a strong emphasis on heart and pulmonary myocardium development, organ induction, and neural development (neuron migration and motor neuron axon guidance), pointing to a cluster of proteins involved in embryonic cardiovascular and nervous system formation. A couple of terms related to innate immunity appear but do not overshadow the dominant developmental theme; they may reflect pleiotropy or annotation noise rather than core function of the cluster.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0008045","count":2}]},{"hash":"279976225703045598","title":"Ubiquitin-Dependent Protein Degradation","description":"Most frequent GO terms center on ubiquitin-dependent protein catabolic processes (GO:0042787), including actin ubiquitination and histone catabolic processes, pointing to proteasome-mediated turnover as a core function. The presence of developmental (rostrocaudal neural tube patterning, axis specification) and immune/regulatory terms (T cell differentiation, homeostasis, necroptosis regulation, viral transcription) suggests these proteins are involved in ubiquitin-mediated regulation that intersects development and immune signaling. Confidence reflects the clear ubiquitin-proteolysis theme driving the cluster label.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0021903","count":3},{"id":"GO:0045623","count":3},{"id":"GO:0036205","count":3},{"id":"GO:0009948","count":3}]},{"hash":"452276925425101428","title":"Craniofacial and neural development","description":"This cluster's top GO terms center on development of craniofacial structures (roof of mouth, skeletal system) and neural patterning (rhombomeres, brain segmentation), with endocrine derivatives like thymus and thyroid arising from pharyngeal regions. Together they point to early embryonic regional specification of head/neck and hindbrain, suggesting a shared developmental program. A few terms (ethylene detection) may be less related or species-specific noise, but the dominant pattern supports embryonic craniofacial and neural development.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":4},{"id":"GO:0048538","count":4},{"id":"GO:0030878","count":4},{"id":"GO:0007501","count":2},{"id":"GO:0021570","count":2}]},{"hash":"1353069759098854403","title":"Neural development and myelination","description":"The leading GO terms cluster around neural development: peripheral nervous system development, embryonic body morphogenesis, and myelination, plus cell adhesion and substrate-dependent migration, all pointing to neural tissue formation and myelin formation. A couple terms (angiogenesis, T cell costimulation) may reflect broader developmental roles or annotation noise but do not dominate the signal.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":4},{"id":"GO:1904237","count":4},{"id":"GO:0001525","count":4},{"id":"GO:2000525","count":4},{"id":"GO:0007422","count":4}]},{"hash":"1149181100156686375","title":"Embryonic brain development and neural patterning","description":"The top GO terms converge on brain-related development: brain segmentation, rhombomere (hindbrain) development, telencephalon regionalization, retrotrapezoid nucleus neuron differentiation, and neural crest formation. A few terms like pancreas development or transcriptional regulation may reflect broader developmental roles or annotation noise, but the dominant theme is embryonic neural patterning and brain regionalization.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0007501","count":2},{"id":"GO:0021570","count":2},{"id":"GO:0048706","count":2},{"id":"GO:0021571","count":2}]},{"hash":"2040491677648218394","title":"Developmental Transcription Regulation","description":"The cluster centers on transcriptional regulation and developmental control, with terms like DNA-templated transcription and negative regulation of Notch signaling, plus positive regulation of myoblast differentiation and vasculogenesis, suggesting a theme of gene expression control during development. Some terms (interferon response, metal ion response, and specific hydroxylation processes) are peripheral and do not clearly fit the core theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045746","count":2},{"id":"GO:0061428","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042264","count":2},{"id":"GO:0036138","count":2}]},{"hash":"769348062117777667","title":"Unknown","description":"The listed GO terms cover diverse processes across different tissues (paracrine signaling; response to glucocorticoid; prostaglandin-related fever; development of mammary/glandular tissues; endothelial, osteoblast, osteoclast, myoblast proliferation/differentiation). There isn\u2019t a single clear function or pathway tying these four proteins together, so a coherent cluster label is not evident. Hence, Unknown with None confidence.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046325","count":1},{"id":"GO:0051384","count":1},{"id":"GO:0071812","count":1},{"id":"GO:0038001","count":1},{"id":"GO:0001937","count":1}]},{"hash":"1929421983280902264","title":"Actin Cytoskeleton Dynamics and Endocytosis Regulation","description":"The cluster is dominated by actin-related processes (Arp2/3-mediated nucleation, sarcomere organization, endocytosis regulation) and calcium signaling, pointing to cytoskeletal remodeling and membrane trafficking as the core theme, with a few outlier terms related to chromatin or development.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016344","count":4},{"id":"GO:0009825","count":4},{"id":"GO:0043983","count":4},{"id":"GO:0034314","count":4},{"id":"GO:0042766","count":4}]},{"hash":"2051786702133550769","title":"CNS Axon Guidance and Neuron Migration","description":"The terms cluster around central nervous system development, with emphasis on axon guidance (Roundabout signaling, retinal and CNS neuron axon guidance), neuron migration, and early synapse formation, along with supporting roles for myelination and extracellular matrix. This suggests a cohesive theme of CNS connectivity and maturation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0022038","count":4},{"id":"GO:0021836","count":4},{"id":"GO:0051965","count":4}]},{"hash":"1670406789267573497","title":" Regulation of erythrocyte and megakaryocyte differentiation","description":"The top GO terms are dominated by regulation of erythrocyte differentiation (including primitive erythrocyte) and positive regulation of megakaryocyte differentiation, pointing to a hematopoietic lineage\u2013specific regulatory theme. Other terms (metabolic and apoptotic-context) are weaker signals and do not contradict the central differentiation-focused pattern, so the cluster most likely represents regulators of erythrocyte/megakaryocyte differentiation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010725","count":2},{"id":"GO:0045648","count":2},{"id":"GO:0045654","count":2},{"id":"GO:0006214","count":1},{"id":"GO:0006552","count":1}]},{"hash":"1911706198604943748","title":"ECM Remodeling and Inflammation","description":"The top GO terms cluster around extracellular matrix formation and remodeling (heparin proteoglycan biosynthesis, elastic fiber assembly, angiogenesis, cell adhesion) and inflammatory signaling (interleukin-1 response, MIF pathway), with UV protection noted, suggesting a connective tissue/skin context where ECM remodeling and inflammation are linked.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034116","count":3},{"id":"GO:0051005","count":3},{"id":"GO:0030210","count":3},{"id":"GO:2000446","count":3},{"id":"GO:0009650","count":3}]},{"hash":"1978368268282930711","title":"Neural development and brain patterning","description":"The terms point to early neural/CNS development and regional brain patterning, including retina development, brain segmentation, hindbrain rhombomere formation, telencephalon regionalization, and neural crest formation. While a couple of terms touch broader embryogenesis (mesodermal fate, skeletal system), the dominant theme is neural development and brain regionalization.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0007501","count":1},{"id":"GO:0021570","count":1},{"id":"GO:0048706","count":1}]},{"hash":"2103147698764463584","title":"Pigment cell signaling and tissue remodeling","description":"The cluster\u2019s GO terms cluster around pigment cell biology (melanocyte differentiation and adhesion) and tissue remodeling processes (angiogenesis, wound healing, cell migration). Although there are some signaling components (e.g., STAT phosphorylation and extrinsic apoptotic signaling) that are broader, the combination of melanocyte-related terms with angiogenesis and wound-healing signals suggests a module focused on pigment cell signaling coupled to tissue remodeling. This makes the label intuitive and relatively specific for the cluster\u2019s likely function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045765","count":2},{"id":"GO:0006931","count":1},{"id":"GO:0061041","count":1},{"id":"GO:0097191","count":1},{"id":"GO:0045773","count":1}]},{"hash":"1440272565980368443","title":"Craniofacial skeletal development and hindbrain patterning","description":"This cluster is driven by GO terms linked to embryonic cranial skeleton morphogenesis, mesodermal cell fate specification, rhombomere development, and brain segmentation, together pointing to an embryonic skeletal formation program in the craniofacial region and hindbrain patterning. Some terms appear unrelated (plant-specific processes), suggesting potential annotation noise, but the dominant theme supports craniofacial skeletal development and hindbrain segmentation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":2},{"id":"GO:0007501","count":1},{"id":"GO:0021570","count":1},{"id":"GO:0048706","count":1},{"id":"GO:0021571","count":1}]},{"hash":"1414844564245003225","title":"Neuronal receptor signaling and behavior","description":"Based on frequent GO annotations in the cluster, including acetylcholine receptor signaling, GABA receptor clustering, and serotonin receptor signaling, along with behavioral-related terms such as startle response, adult walking behavior, conditioned taste aversion, and vestibulocochlear nerve development, the proteins appear to participate in neural signaling and regulation of behavior. A single term for heme A biosynthetic process is present but does not align with the predominant neural theme, likely reflecting a general metabolic annotation rather than core cluster function. Therefore, the label captures the shared function of neurotransmitter receptor signaling and behavior modulation.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006784","count":1},{"id":"GO:0051970","count":1},{"id":"GO:0001661","count":1},{"id":"GO:0095500","count":1},{"id":"GO:0001964","count":1}]},{"hash":"2048736224932032875","title":"Unknown","description":"The terms span temperature response and thermogenesis, pain perception, photoreceptor maintenance, vasopressin regulation, IL-1\u03b2 production, dendritic cell differentiation, cell proliferation, PKA activity, and blood coagulation. This mix suggests diverse roles across stress response, immune signaling, and vascular/hormonal processes, with no single cohesive function uniting the cluster. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0045494","count":2},{"id":"GO:0001992","count":2}]},{"hash":"2094405618160036902","title":"GPCR-Mediated Immune-Vascular Signaling","description":"This cluster centers on signaling pathways that regulate immune cell functions and vascular processes, as reflected by GO terms related to GPCR/cAMP signaling (adenylate cyclase and PKA), IL-1 beta production, dendritic cell differentiation, vasopressin-regulated blood pressure, and coagulation. Temperature and photoreceptor-related terms may reflect broader stress signaling that can converge on GPCR/cAMP pathways, but the core theme ties immune activation to vascular regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":3},{"id":"GO:0001992","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0032651","count":3},{"id":"GO:0097029","count":3}]},{"hash":"1987593827703365918","title":"Branched-chain amino acid and fatty acid oxidation","description":"These proteins cluster around catabolic pathways for branched-chain amino acids (leucine, valine) and fatty acids, including long-chain fatty acid beta-oxidation and carnitine metabolism, suggesting a shared role in energy generation from lipids and amino acids. Although there are organ-development terms (liver, heart) present, the dominant theme is metabolic catabolism and energy production. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006552","count":1},{"id":"GO:0006574","count":1},{"id":"GO:0033539","count":1},{"id":"GO:0019254","count":1},{"id":"GO:0042758","count":1}]},{"hash":"1725325552198431558","title":"Neural development and synapse formation","description":"The GO terms cluster around neural patterning and connectivity: axon guidance (commissural), fasciculation, optic nerve morphogenesis, dendritic spine morphogenesis, and synapse assembly, all indicating neuronal development and synaptic organization. A few terms touch on thyroid hormone or retinoic acid signaling and immune-related processes, but the dominant signal is neurodevelopmental and synaptic.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048671","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0071679","count":1},{"id":"GO:0042403","count":1},{"id":"GO:2000525","count":1}]},{"hash":"1321881127210704491","title":"Lipid and retinoid metabolism","description":"The terms cluster around lipid biosynthesis and metabolism (very long-chain fatty acids, fatty acid elongation, sphingolipid biosynthesis) and retinoid pathways (retinol and retinoic acid biosynthesis), suggesting a cohesive lipid/retinoid metabolic module. Some terms like lung development or tropane alkaloid biosynthesis are peripheral or cross-species annotations, but the dominant signal supports this theme.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0009710","count":1},{"id":"GO:0042761","count":1},{"id":"GO:0031427","count":1}]},{"hash":"486824063965277966","title":"Unknown","description":"The GO terms are scattered with iron-sulfur cluster assembly as the only cohesive signal, while other terms (antibiotic and biotin biosynthesis, stress response, and several obsolete processes) do not form a single clear theme, so a specific, representative label is not discernible.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016226","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0017000","count":1},{"id":"GO:0009413","count":1},{"id":"GO:0009102","count":1}]},{"hash":"1313173314627332356","title":"Multitissue Development and Morphogenesis","description":"The top GO terms are dominated by development and morphogenesis across multiple tissues (neural retina, foregut, epidermis, heart), suggesting a broad role in tissue formation rather than a single pathway. Some terms like memory or cellular ATP response are more general cellular processes, but the common theme appears to be developmental processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007613","count":2},{"id":"GO:0070986","count":2},{"id":"GO:0061074","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0071318","count":2}]},{"hash":"1213988777506006212","title":"Bacterial lipoteichoic acid and fatty acid biosynthesis","description":"GO terms such as lipoteichoic acid biosynthesis and fatty acid biosynthetic processes, plus acetyl-CoA\u2013related pathways, point to a cohesive bacterial lipid biosynthesis module and cell envelope component production. While some terms are obsolete or plant-specific and may reflect annotation noise, the strongest signal centers on lipid metabolism and lipoteichoic acid-related assembly in Gram-positive bacteria.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":3},{"id":"GO:0019542","count":2},{"id":"GO:0019427","count":2},{"id":"GO:0010124","count":2},{"id":"GO:1902987","count":2}]},{"hash":"2125349028721976389","title":"Unknown","description":"The GO terms are diverse and include insulin response, transcription, fruit ripening, various biosynthetic and metabolic processes, plus several obsolete annotations. There is no clear, shared function tying these four proteins together, so a cohesive label cannot be inferred.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0009835","count":1},{"id":"GO:0033362","count":1},{"id":"GO:0019518","count":1}]},{"hash":"560909751531951440","title":"Actin Remodeling and Cell Polarity","description":"The top GO terms center on actin cytoskeleton dynamics (lamellipodium assembly, actin reorganization) and polarity establishment, with signaling inputs from Rho and PKC pathways. While there are also terms related to immune activation and vesicle trafficking, the dominant theme tying the cluster together is cytoskeletal remodeling and cell polarity.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":2},{"id":"GO:0031532","count":2},{"id":"GO:2000553","count":2},{"id":"GO:0099525","count":2},{"id":"GO:0070528","count":2}]},{"hash":"227549160968053846","title":"Keratinocyte and Skin Development","description":"The top GO terms cluster around keratinocyte biology and skin formation (keratinocyte development, keratinization, regulation of epidermal cell division, skin development), indicating a cohesive theme of epidermal/keratinocyte processes. A couple of terms (e.g., substantia nigra development, membrane depolarization) appear less related, suggesting some noise, but the dominant signal supports the label.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0086010","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0034766","count":2},{"id":"GO:0010839","count":2},{"id":"GO:0021762","count":2}]},{"hash":"2140899397193700491","title":"Mitochondrial DNA Repair","description":"Dominant signals come from mitochondrial DNA maintenance activities: mitochondrial double-strand break repair via homologous recombination and base-excision repair are highlighted, suggesting a core theme of preserving mitochondrial genome integrity. Supporting terms hint at broader cellular stress responses and regulation (redox balance, signaling, and cell-cycle control), but the clearest cluster focus is mitochondrial DNA repair/maintenance.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097552","count":2},{"id":"GO:0043488","count":1},{"id":"GO:2001153","count":1},{"id":"GO:0007568","count":1},{"id":"GO:1900087","count":1}]},{"hash":"2218548461261187797","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016064","count":1},{"id":"GO:0034145","count":1},{"id":"GO:0034162","count":1},{"id":"GO:0045410","count":1},{"id":"GO:0002781","count":1}]},{"hash":"1454967631826978930","title":"NF-kB signaling and histone ubiquitination","description":"These terms converge on NF-kappaB pathway activation (I-kappaB phosphorylation, TNF signaling) and ubiquitin-dependent proteolysis, with additional histone catabolic and histone ubiquitination/modification processes linking signaling to chromatin remodeling. The cluster likely represents regulators coordinating inflammatory signaling with chromatin state.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":3},{"id":"GO:1901253","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0036205","count":2},{"id":"GO:1903721","count":2}]},{"hash":"1536999696188234986","title":"Neuronal signaling and synaptic exocytosis","description":"The top GO terms point to nervous system development, calcium-dependent exocytosis, and synaptic activity (excitatory postsynaptic potential), along with signaling pathways like ephrin, JNK, and Hedgehog. This pattern suggests the proteins participate in neuronal communication and regulation of exocytosis during neural development and synaptic signaling. Some terms about mast cell degranulation and actin reorganization are related but appear less central to the core theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045956","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0031532","count":3},{"id":"GO:0043304","count":3},{"id":"GO:0043552","count":3}]},{"hash":"2244878190077982327","title":"Bacterial cell envelope polysaccharide biosynthesis","description":"The top GO terms cluster around biosynthesis of polysaccharide components of the bacterial cell envelope\u2014slime layer polysaccharides, lipopolysaccharide core, cell wall organization, and GDP-mannose\u2013dependent glycan biosynthesis\u2014suggesting proteins involved in envelope biogenesis rather than core metabolism. Although some terms are obsolete, the common theme is envelope polysaccharide production and assembly.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006535","count":1},{"id":"GO:0019877","count":1},{"id":"GO:0045228","count":1},{"id":"GO:0009245","count":1},{"id":"GO:0000902","count":1}]},{"hash":"2239268084020388466","title":"Vesicle trafficking and exocytosis","description":"The GO terms point to intracellular vesicle transport across ER, ERGIC, Golgi, endosomes, and vacuoles, with vesicle fusion and targeted delivery to membranes (including receptor insertion and neutrophil degranulation). This cohesive pattern indicates a secretory/trafficking pathway rather than a single metabolic function.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":1},{"id":"GO:0098967","count":1},{"id":"GO:0042147","count":1},{"id":"GO:0016240","count":1},{"id":"GO:0042144","count":1}]},{"hash":"2197996779895465999","title":"Histone ubiquitination and telomere heterochromatin","description":"This cluster is driven by GO terms tying histone ubiquitination (free ubiquitin chain polymerization; histone monoubiquitination) to subtelomeric/telomeric chromatin regulation (subtelomeric heterochromatin formation, heterochromatin maintenance, negative regulation of chromatin silencing at telomere). Additional terms related to chromatin dynamics and DNA damage response (global genome nucleotide-excision repair) support a nucleus-facing, chromatin-assembly/maintenance theme. Some peripheral terms (viral process, obsolete signaling terms) appear less connected, but the core pattern links ubiquitination to telomeric chromatin maintenance. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010994","count":4},{"id":"GO:0070423","count":4},{"id":"GO:0006348","count":4},{"id":"GO:0010390","count":4},{"id":"GO:0006344","count":4}]},{"hash":"1832273708160566801","title":"Ubiquitin-Dependent Signaling in Neural and Muscle Development","description":"The top GO terms center on ubiquitination and ubiquitin-dependent proteolysis, with concurrent regulation of protein kinase activity and signaling. Additional terms point to nervous system development, skeletal muscle differentiation, and regulation of synaptic vesicle endocytosis and mechanical stimulus response, suggesting a theme of ubiquitin-mediated control of signaling during neural and muscle development.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:1900242","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0042787","count":2}]},{"hash":"735103669640558553","title":"Organelle protein import (mitochondria and chloroplasts)","description":"Several top GO terms point to protein import into mitochondria (matrix and inner membrane) and into chloroplast stroma, suggesting the proteins cluster around organelle targeting/import processes rather than a single metabolic pathway. An unrelated obsolete term appears, but the main signal is import into organelle compartments.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":2},{"id":"GO:0045039","count":2},{"id":"GO:0045037","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0030150","count":2}]},{"hash":"72561565288646405","title":"Proteoglycan Biosynthesis and Metabolism","description":"The top GO terms cluster around biosynthesis and metabolic processes of proteoglycans (heparan, dermatan, chondroitin) and related glycosaminoglycans, with supporting terms like polysaccharide localization and developmental roles in cartilage and kidney structures. This suggests the proteins collectively function in proteoglycan production and turnover, with some involvement in tissue development.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015014","count":2},{"id":"GO:0015015","count":2},{"id":"GO:0060676","count":2},{"id":"GO:0030202","count":2},{"id":"GO:0050655","count":2}]},{"hash":"99079427425911936","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1902474","count":1},{"id":"GO:1902354","count":1},{"id":"GO:0051932","count":1}]},{"hash":"959177061942759066","title":"Broad stimulus-response signaling","description":"These proteins are annotated with GO terms spanning responses to environmental and internal cues across systems (temperature and ion sensing, chemical stimulus detection, aerotaxis, vestibular development, cardiac electrical activity, and immune regulation). The common thread is involvement in sensing or transducing diverse stimuli, suggesting a broad, multisystem stimulus-response/signaling role rather than a single coherent pathway. The lack of direct interactions (Edges 0) supports a general thematic label rather than a tight functional module.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":3},{"id":"GO:0097623","count":3},{"id":"GO:0071286","count":3},{"id":"GO:0050968","count":3},{"id":"GO:0021750","count":3}]},{"hash":"1577451375613862316","title":"Nucleotide Biosynthesis and Phosphorylation","description":"Most of the top GO terms cluster around nucleotide biosynthesis and phosphorylation (dTDP, dUDP, dTTP biosynthetic processes; TMP metabolic process; nucleoside monophosphate phosphorylation), indicating a shared role in nucleotide synthesis and remodeling. A few other terms (myoblast differentiation, response to estrogen, growth factor stimulus, response to cadmium ion) appear but are less central, likely reflecting pleiotropy or broader annotations. Therefore, the cluster is best described as a nucleotide metabolism module.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006233","count":1},{"id":"GO:0045445","count":1},{"id":"GO:0043627","count":1},{"id":"GO:0071363","count":1},{"id":"GO:0046686","count":1}]},{"hash":"750737828011292560","title":"Embryonic development and tissue differentiation","description":"The top GO terms span left-right patterning, endocrine system development, pancreatic beta cell development, EMT in heart cushion formation, placental trophoblast differentiation, and cartilage morphogenesis. These collectively point to broad embryonic development and differentiation across multiple tissues rather than a single functional module.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060707","count":2}]},{"hash":"1693651118666121484","title":"Neural crest and hindbrain development","description":"The GO terms cluster around embryonic neural development, including neural crest formation, brain segmentation, hindbrain rhombomere formation (rhombomeres 4 and 5), and brain regionalization, with additional but less central terms for broader embryonic skeletal and organ development. This suggests a theme of early neural crest\u2013mediated development and hindbrain patterning, justifying the label.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007501","count":1},{"id":"GO:0021570","count":1},{"id":"GO:0048706","count":1},{"id":"GO:0021571","count":1},{"id":"GO:0035284","count":1}]},{"hash":"742456606423373359","title":"Inhibitors of Transcription and Immune Signaling","description":"The cluster shows a strong presence of negative regulation terms across multiple processes: transcription by RNA Pol II, protein kinase activity, germinal center and T-helper cell regulation, NLRP3 inflammasome assembly, ubiquitination, and autophagy, with vitamin D response also tying into immune modulation. This pattern supports a cohesive role as broad inhibitors affecting transcription, signaling, autophagy, and immune pathways.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0006469","count":2}]},{"hash":"388409049456779754","title":"Unknown","description":"The terms span fat cell differentiation, hippocampus development, melanosome transport, immune signaling, and synaptic regulation, with no single dominant process linking them. There are no interactions to anchor a specific function, so a cohesive label isn\u2019t evident.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0032402","count":2},{"id":"GO:0043124","count":1},{"id":"GO:0016064","count":1}]},{"hash":"99635475668099141","title":"Unknown","description":"The top GO terms cover temperature response, sensory perception, ion transport, development in vestibular and cardiac contexts, immune regulation, and chemotaxis, showing no single coherent function or pathway binding these proteins. Due to this heterogeneity, a concise label that accurately represents the cluster cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":2},{"id":"GO:0097623","count":2},{"id":"GO:0050968","count":2},{"id":"GO:0021750","count":2},{"id":"GO:0002724","count":2}]},{"hash":"1423323146599027572","title":"Regulatory signaling and transcription control","description":"The proteins cluster around regulation of transcription and signaling pathways, including transcriptional regulation (GO:0006355, GO:0000122) and innate immune signaling via the MyD88-dependent TLR4 pathway, with additional links to apoptosis, necroptosis, cell cycle regulation, and polyubiquitination. This points to a broader theme of regulatory control over gene expression and cellular signaling rather than a single specific pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0035660","count":1},{"id":"GO:0007527","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0000122","count":1}]},{"hash":"1022123683785052161","title":"Semaphorin-plexin signaling in axon guidance","description":"The top GO terms point to semaphorin-plexin signaling and axon guidance (e.g., axon guidance and nerve organization), with broader neural development terms also present. Several entries highlight roles in neuronal patterning, consistent with semaphorin pathways, while a few bone and endothelial morphogenesis terms likely reflect shared signaling contexts. Overall, the cluster appears centered on semaphorin-mediated neuronal guidance, with development beyond neurons as a secondary theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:1902287","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0001886","count":2},{"id":"GO:0021637","count":2}]},{"hash":"387845970459926280","title":"Left-right patterning and endocrine organ development","description":"The top GO terms point to left-right pattern formation and various organ/craniofacial development processes (endocrine system, pancreatic cell, and roof of mouth development), suggesting a coherent focus on developmental programs, though the presence of generic cellular-process terms tempers certainty.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0042542","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0035270","count":4}]},{"hash":"2067191587257871172","title":"Ribosome Biogenesis and Kinase Activation","description":"The cluster\u2019s top GO terms point to two related but distinct processes: ribosome biogenesis and activation of protein kinase activity. This suggests the proteins may be involved in both ribosome-related assembly/regulation and broader signaling or regulatory phosphorylation events, but with only two modestly supported terms and no interaction data, the link is weak. Confidence: Low","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0032147","count":1}]},{"hash":"1999886463311015470","title":"Mitochondrial energy metabolism and immune signaling","description":"This cluster shows GO terms tied to ATP synthesis and proton transport, pointing to mitochondrial energy production, alongside terms related to immune signaling (TNF production, monocyte chemotaxis, purinergic signaling). Other terms about protein stabilization or chaperone assembly appear ancillary. Taken together, the proteins seem to bridge energy metabolism with cell signaling, especially inflammatory signaling, rather than representing a single tightly cohesive function.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042773","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0052212","count":1},{"id":"GO:0090026","count":1},{"id":"GO:0035590","count":1}]},{"hash":"1462378302621503420","title":"Adhesion and Immune Receptor Signaling","description":"The terms cluster around cell adhesion processes (homophilic adhesion and regulation of adhesion molecule production) and immune receptor signaling (C-type lectin receptor, Fc-gamma receptor signaling, basophil activation), with additional items touching on development and response to fungal molecules. This suggests proteins involved in cell-cell interactions embedded in immune signaling contexts, possibly in epithelial/immune interfaces. Therefore, the label Adhesion and Immune Receptor Signaling fits best.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":2},{"id":"GO:0007213","count":2},{"id":"GO:0072237","count":2},{"id":"GO:0071226","count":2},{"id":"GO:0045575","count":2}]},{"hash":"2034957690953991957","title":"Membrane Solute Transporters","description":"The top GO terms are dominated by transmembrane transport of various substrates (glucose, xylose, urate, selenite, etc.) and related plasma membrane transport processes, suggesting the proteins function as solute transporters. A couple of terms about glucose starvation response and senescence appear incidental and do not define the core function. Overall, the cluster seems to collect membrane transporter proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0070715","count":1},{"id":"GO:1904728","count":1},{"id":"GO:0015753","count":1}]},{"hash":"272096650464130893","title":"Proteostasis and stress response","description":"The GO terms clustered here largely point to cellular maintenance of protein homeostasis and response to stress: autophagy, deglycation/mitochondrial methylglyoxal detoxification, regulation of SOD activity, and ubiquitin-related control of protein degradation (including negative regulation of K48-linked deubiquitination). Additional terms about transcription and nuclear localization suggest coordinated gene expression changes and nuclear trafficking under stress. Taken together, these features fit a module focused on proteostasis and stress response.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903094","count":1},{"id":"GO:2000277","count":1},{"id":"GO:0006541","count":1},{"id":"GO:0036530","count":1},{"id":"GO:0006914","count":1}]},{"hash":"1690571488808281690","title":"Unknown","description":"The GO terms are scattered across diverse cellular processes (epigenetic regulation, ribosome assembly, mitochondrial fusion, endocytosis, deubiquitination, calcium signaling, insecticide response, tail-anchored protein insertion into ER, and neurotransmitter release). There is no clear shared function or pathway linking these proteins, so a cohesive label is not warranted.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":2},{"id":"GO:0000028","count":2},{"id":"GO:0010636","count":2},{"id":"GO:1900186","count":2},{"id":"GO:0016579","count":2}]},{"hash":"1427170536278153131","title":"Unknown","description":"The GO terms are highly diverse, including DNA methylation regulation, ribosome assembly, mitochondrial fusion, endocytosis regulation, deubiquitination, calcium channel regulation, embryonic cell cycle, and nuclear body organization, with no clear single theme linking the proteins. This makes a cohesive, specific label difficult to justify.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":2},{"id":"GO:0000028","count":2},{"id":"GO:0010636","count":2},{"id":"GO:1900186","count":2},{"id":"GO:0043433","count":2}]},{"hash":"1548372509647480283","title":"Nuclear ubiquitination and DNA repair","description":"This cluster shows recurrent terms tied to protein ubiquitination and deubiquitination, histone turnover, PML body organization, and nucleotide-excision repair, all pointing to chromatin regulation and genome maintenance in the nucleus. Some mitochondria-related terms are present but appear peripheral to the main nuclear theme, suggesting the core function is nuclear protein modification and DNA repair processes.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0010636","count":1},{"id":"GO:0070050","count":1},{"id":"GO:0016579","count":1},{"id":"GO:0036205","count":1}]},{"hash":"30356177508620590","title":"Cerebral cortex development and neural connectivity","description":"The proteins cluster around cortical layer formation, axonogenesis, corpus callosum development, and synapse assembly, with angiogenesis and Rho signaling supporting morphogenesis; a few terms reflect innate immune responses that can be active in brain development.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021819","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007266","count":3}]},{"hash":"1266586061791037054","title":"Unknown","description":"The terms span diverse biological processes\u2014from cytokinesis regulation and transcriptional control to various differentiation events and even memory and nuclear import\u2014with no clear, single function tying the three proteins together. A cohesive, specific label isn\u2019t supported by the GO terms here.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032465","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0060487","count":3},{"id":"GO:0043547","count":3},{"id":"GO:1903861","count":2}]},{"hash":"705574687147863944","title":"Cardiovascular development and cell migration","description":"The top GO terms point to heart development (cardiac muscle cell development, adult heart development), glomerulus development, and ECM-related processes like elastic fiber assembly, plus VEGF-regulated actin nucleation and cell migration, suggesting tissue remodeling and cardiovascular formation driven by cell motility. Immune terms (T cell immunity and migration) appear but are less central; overall, the dominant theme is cardiovascular development with migratory behavior.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048739","count":1},{"id":"GO:0002456","count":1},{"id":"GO:0006930","count":1},{"id":"GO:0032835","count":1},{"id":"GO:0038089","count":1}]},{"hash":"1136695947419776012","title":"Meiosis/Mitosis Machinery and DNA Damage Response","description":"This cluster\u2019s top GO terms point strongly to cell division and genome maintenance, including ascospore formation (meiotic development), positive regulation of mitotic contractile ring assembly (cytokinesis), kinetochore localization, meiotic recombination repair, and DNA damage checkpoint regulation. While some terms like EMT or immune signaling are present, the core recurring theme centers on mitosis/meiosis machinery and DNA damage response, suggesting proteins involved in chromosome segregation, spindle function, and genome stability.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030437","count":3},{"id":"GO:1903501","count":3},{"id":"GO:0031987","count":3},{"id":"GO:0001837","count":3},{"id":"GO:0043029","count":3}]},{"hash":"1318717260540841070","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090669","count":1},{"id":"GO:0031120","count":1},{"id":"GO:0031119","count":1},{"id":"GO:0031118","count":1},{"id":"GO:0000495","count":1}]},{"hash":"2133330684536508681","title":"DNA replication and repair","description":"The cluster\u2019s GO terms are dominated by DNA metabolism, including mitochondrial and plastid DNA replication, viral DNA genome replication, base-excision repair, double-strand break repair, intrachromosomal recombination, and DNA biosynthesis. This pattern points to a core theme of genome maintenance and replication across organelles and genomes, with a few peripheral terms that are less central to this function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0055093","count":1},{"id":"GO:0033259","count":1},{"id":"GO:0006287","count":1}]},{"hash":"722123009257090695","title":"DNA Damage Response and p53-Mediated Transcription Regulation","description":"Terms center on p53-mediated DNA damage response, transcription regulation, and UV/gamma radiation signaling, with related translation regulation and ribosome biogenesis, suggesting a DNA damage response module.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032784","count":1},{"id":"GO:1902167","count":1},{"id":"GO:1902164","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0006353","count":1}]},{"hash":"437900786585701264","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0046825","count":1},{"id":"GO:1901621","count":1},{"id":"GO:0034975","count":1}]},{"hash":"619631653713719172","title":"Cytoskeleton Dynamics and Cell Migration","description":"The GO terms point to cytoskeletal rearrangements (actin/microtubules), mitotic/microtubule-associated processes, and cell movement (nuclear migration, wound healing, degranulation regulation), suggesting a cohesive theme around cytoskeleton-driven movement and division; a few terms reflect broader signaling roles but do not override the core theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043124","count":1},{"id":"GO:1902307","count":1},{"id":"GO:0031532","count":1},{"id":"GO:0007097","count":1},{"id":"GO:0044319","count":1}]},{"hash":"1046852566427879026","title":"Unknown","description":"The GO terms span highly diverse processes (proliferation, memory, sporulation, nuclear import, glucocorticoid response, phosphorylation regulation, EMT, kidney development, cytokinesis, exocytosis), with no clear single theme tying the proteins together. This makes it inappropriate to assign a specific, coherent functional label for the cluster.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0007613","count":2},{"id":"GO:0030437","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0051384","count":2}]},{"hash":"899221151249584278","title":"Nuclear RNA processing and decay","description":"The set of proteins shows strong enrichment for nuclear RNA metabolism: miRNA and snoRNA processing, transcription termination/regulation by RNA polymerase II, nuclear RNA surveillance, and various nuclear RNA decay pathways. This points to a shared theme of RNA maturation and quality control in the nucleus, rather than a single, isolated function, justifying a label centered on nuclear RNA processing and decay.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":2},{"id":"GO:0043144","count":1},{"id":"GO:0034244","count":1},{"id":"GO:0030846","count":1},{"id":"GO:0070651","count":1}]},{"hash":"352694344871677058","title":"Ammonium transport and nitrogen utilization","description":"This cluster centers on GO terms related to nitrogen utilization and transport of ammonium and related compounds (e.g., ammonium, methylammonium, nitrogen utilization), suggesting a shared theme of nitrogen metabolism and ammonium handling. The presence of terms related to nutrient-stress\u2013driven growth changes (pseudohyphal growth and invasive growth in response to glucose limitation) supports a broader context of nutrient stress adaptation observed in fungi. A few terms (lateral root branching, iron homeostasis, carbon dioxide transport) are more general or cross-species, but do not override the dominant nitrogen/ammonium signal.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006808","count":1},{"id":"GO:0001403","count":1},{"id":"GO:0070634","count":1},{"id":"GO:0015670","count":1},{"id":"GO:0015843","count":1}]},{"hash":"1281282978581142400","title":"Spliceosome Regulation and mRNA Processing","description":"The GO terms cluster around post-transcriptional RNA processing: regulation of splicing via the spliceosome, processome assembly, mRNA modification and stabilization, and translation reinitiation. Together these suggest proteins function as spliceosome- and RNA-processing factors that influence mRNA maturation and expression, with one term hinting at ncRNA-mediated regulation. ","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0031047","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0048255","count":2}]},{"hash":"1832353874074914879","title":"Developmental Processes","description":"The terms are dominated by developmental themes across organs and systems (prostatic bud elongation, neural tube patterning, mammary gland and bile duct development, peripheral nervous system development, and sprouting angiogenesis). A minority of terms relate to immune signaling and regulation, but the strongest recurring signal is developmental biology.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060517","count":1},{"id":"GO:0021903","count":1},{"id":"GO:2000761","count":1},{"id":"GO:0034145","count":1},{"id":"GO:0002270","count":1}]},{"hash":"673724571634041396","title":"Methylation-Driven Chromatin and RNA Modification","description":"The top GO terms are dominated by methylation activities (peptidyl-lysine dimethylation, peptidyl-lysine trimethylation, rRNA methylation, RNA guanine-N7 methylation) and include rDNA heterochromatin formation, indicating a core theme of methylation influencing chromatin and RNA modification. A few biosynthetic processes appear but are less representative, so methylation-centric function best defines this cluster.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018027","count":2},{"id":"GO:0031167","count":2},{"id":"GO:0018013","count":1},{"id":"GO:0018023","count":1},{"id":"GO:0000183","count":1}]},{"hash":"117378172431183514","title":"Mitotic control and cellular stress signaling","description":"The top GO terms point to mitotic cell cycle control (mitosis and APC-dependent catabolic process) as the core function, with additional signals of cellular stress responses (ER stress-related translation initiation, oxidative stress responses to hydrogen peroxide and heavy metals) and immune signaling (type I interferon). This suggests a cluster centered on mitotic regulation that also engages stress-response pathways, rather than a single isolated function.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0071357","count":2},{"id":"GO:0010288","count":2},{"id":"GO:1900035","count":2}]},{"hash":"1015796321368371141","title":"Neural development and synaptic signaling","description":"Among the top terms, several clearly point to neural and synaptic processes: short-term memory, regulation of presynaptic cytosolic calcium ion concentration, and regulation of long-term synaptic potentiation, as well as retina layer formation. Although kidney development terms appear, the dominant signal relates to neural development and synaptic function, suggesting this cluster reflects neural signaling and sensory development themes rather than non-neural processes. Confidence: Medium","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072221","count":3},{"id":"GO:0010842","count":3},{"id":"GO:0035191","count":3},{"id":"GO:0007614","count":3},{"id":"GO:2000678","count":3}]},{"hash":"1090771606580279886","title":"RNA processing and splicing machinery (nucleus)","description":"Most terms relate to RNA metabolism and processing\u2014transcription termination, spliceosome assembly/splicing, rRNA and tRNA maturation, and mRNA decapping/processing\u2014along with nuclear import; a few terms touch on P-body assembly reflecting mRNA decay, but overall it\u2019s a cohesive RNA processing/splicing cluster.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":3},{"id":"GO:0000290","count":3},{"id":"GO:0000387","count":3},{"id":"GO:0033962","count":3},{"id":"GO:0070317","count":3}]},{"hash":"1575547808348128337","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0045723","count":1},{"id":"GO:0007568","count":1},{"id":"GO:1901671","count":1}]},{"hash":"2298458937434063588","title":"Developmental gene regulation","description":"The GO terms cluster around developmental processes (heart and retina development) and chromatin-level control of gene expression (transcription initiation-coupled chromatin remodeling, nucleosome disassembly, ubiquitination), suggesting these proteins act as regulators of developmental programs rather than a single enzyme or pathway. Confidence: Medium.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003283","count":1},{"id":"GO:0003407","count":1},{"id":"GO:0048096","count":1},{"id":"GO:0016567","count":1},{"id":"GO:0003219","count":1}]},{"hash":"1883732242263516263","title":"Immune signaling and apoptotic regulation","description":"The top GO terms point to both innate and adaptive immune signaling (MyD88-dependent TLR signaling, immunoglobulin-mediated responses, B cell proliferation control) and regulation of cell death (AICD, extrinsic apoptotic signaling, necroptosis, IL-13 modulation). This suggests a cohesive theme of immune activation with checks and balances, spanning signaling and programmed cell death.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006924","count":2},{"id":"GO:0016064","count":1},{"id":"GO:1902622","count":1},{"id":"GO:0030889","count":1},{"id":"GO:2000002","count":1}]},{"hash":"1420918985746246708","title":"Unknown","description":"The top GO terms span apoptosis, immune regulation, development, and general stress responses with no single dominant theme tying the proteins together, especially given the small cluster size; therefore a single cohesive label is not supported.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006309","count":2},{"id":"GO:0051384","count":2},{"id":"GO:0030889","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0045736","count":2}]},{"hash":"632537966134070093","title":"Unknown","description":"The top GO terms cover a wide range of differentiation and development across many tissues and species (melanocytes, neural crest\u2013derived heart structures, vestibular system, heart rate regulation, plant stomata, inner ear cells, pancreatic and stomach neuroendocrine cells, osteoblasts, and myelination). There is no single cohesive function or pathway that links these terms, suggesting no clear common theme for the cluster. ","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030318","count":3},{"id":"GO:0003253","count":3},{"id":"GO:0021750","count":3},{"id":"GO:0003062","count":3},{"id":"GO:0010374","count":3}]},{"hash":"1693232472326532518","title":"Neuronal excitability and survival signaling","description":"This cluster is driven by GO terms related to neuronal activity and cell survival, notably excitatory postsynaptic potential and negative regulation of neuron apoptotic processes, which point to neuronal signaling and anti-apoptotic regulation. While there are additional terms spanning cytoskeletal dynamics, nuclear migration, and immune-related processes, the most represented functions center on neurons and their excitability/survival, justifying a neuronal-focused label with Medium confidence.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0043124","count":1},{"id":"GO:1902307","count":1},{"id":"GO:0031532","count":1}]},{"hash":"1514673116898526728","title":"Multitissue Development and Differentiation","description":"GO terms span vascular remodeling, heart valve formation, blood cell development, neural and tracheal development, and broad regulatory processes, suggesting a general developmental/differentiation role across tissues rather than a single pathway.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000504","count":1},{"id":"GO:0007296","count":1},{"id":"GO:0035855","count":1},{"id":"GO:0003199","count":1},{"id":"GO:0035190","count":1}]},{"hash":"1291193432085958172","title":"Cellular stress response and protein folding","description":"The GO terms show a consistent theme of stress responses (interferon signaling, oxidative stress, unfolded protein response/ER stress) and protein homeostasis (protein peptidyl-prolyl isomerization, translation regulation during ER stress), suggesting these proteins function in managing cellular stress and proteostasis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0071357","count":3},{"id":"GO:0010288","count":3},{"id":"GO:0070301","count":3},{"id":"GO:0036494","count":3},{"id":"GO:0031145","count":3}]},{"hash":"2033570197562222993","title":"Developmental gene regulation and DNA repair","description":"The terms cluster around developmental processes (mesoderm development, hair follicle morphogenesis, left\u2013right pattern formation, vulval cell fate specification, pancreatic cell development) and core gene expression control (mRNA splicing, RNA Pol II regulation). A single strand break repair term adds a genome maintenance facet, but the dominant signal is developmental patterning guided by transcriptional and post-transcriptional regulation. This supports labeling the group as developmental gene regulation with a minor DNA repair component.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010957","count":1},{"id":"GO:0000398","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0031069","count":1},{"id":"GO:0007498","count":1}]},{"hash":"1441433301708990249","title":"Neural development and myelination","description":"GO terms point to nervous system formation (peripheral nervous system development, embryonic body morphogenesis), myelination, and cell adhesion, with angiogenesis suggesting broader developmental context; together they suggest a cluster focused on neural development and myelin formation. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":3},{"id":"GO:1904237","count":3},{"id":"GO:0001525","count":3},{"id":"GO:2000525","count":3},{"id":"GO:0007422","count":3}]},{"hash":"62277653089373622","title":"Unknown","description":"The GO terms across this cluster are highly heterogeneous (amino acid catabolism, redox, xenobiotic response, chromatin regulation, hormone biosynthesis, reproduction). No single pathway or molecular function unites the set, and some terms even appear obsolete; therefore a cohesive, intuitive label can't be deduced.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042853","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0060992","count":1},{"id":"GO:0035563","count":1},{"id":"GO:0043046","count":1}]},{"hash":"248146191034564544","title":"Unknown","description":"The GO terms are diverse and span cholesterol homeostasis, immune signaling (TLR9, interferon pathways), and various developmental processes, with no clear shared function tying the proteins together. There are no edges connecting the proteins, and the terms do not converge on a single coherent theme, so a specific functional label cannot be justified. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042632","count":3},{"id":"GO:0035726","count":3},{"id":"GO:0043124","count":3},{"id":"GO:0070166","count":3},{"id":"GO:0010980","count":3}]},{"hash":"1484658053570227538","title":"Immune Signaling and Development","description":"This cluster centers on immune signaling (TLR9 pathway, IL-6 production, T cell costimulation) and growth/remodeling processes (angiogenesis, positive regulation of cell proliferation and migration), with additional developmental terms (peripheral nervous system development, embryonic morphogenesis). The combination suggests a theme of immune-regulated development or inflammation-driven tissue remodeling rather than a single narrow function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":1},{"id":"GO:1904237","count":1},{"id":"GO:0034162","count":1},{"id":"GO:0001525","count":1},{"id":"GO:0045410","count":1}]},{"hash":"1124391084116193751","title":"Unknown","description":"The GO terms are highly diverse, spanning transcription, vesicle formation, ER organization, DNA transformation competence, and gas vesicle organization, with no clear shared function linking the proteins.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090261","count":1},{"id":"GO:0070676","count":1},{"id":"GO:0030420","count":1},{"id":"GO:0051131","count":1},{"id":"GO:0006351","count":1}]},{"hash":"897649830637172849","title":"Apoptosis and developmental signaling (Hippo/TRK)","description":"This cluster prominently features GO terms for apoptosis execution, DNA fragmentation, and response to staurosporine, indicating a strong apoptosis-related signal. It also includes Hippo signaling and TRK/neurotrophin pathways, plus several development terms (heart, hippocampus, compound eye), suggesting these proteins may participate in developmental signaling that intersects with cell death and growth regulation. The strongest theme is apoptosis, with supportive developmental signaling context.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097194","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0035329","count":3},{"id":"GO:0048011","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1150604661399393718","title":"Endosomal Transport to Lysosome and Golgi","description":"I named it Endosomal Transport to Lysosome and Golgi because the majority of top GO terms describe endosomal trafficking routes (endosome to lysosome, early to late endosome, endosome to Golgi, and cytoplasm to vacuole targeting). A few regulatory terms (e.g., GTPase activity regulation, NF-kappaB signaling) can accompany vesicle trafficking proteins but do not alter the core theme of intracellular endosomal transport.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008333","count":3},{"id":"GO:0045022","count":3},{"id":"GO:0032258","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0034498","count":3}]},{"hash":"1793281482298029096","title":"Signaling and membrane transport","description":"The top GO terms cluster around cellular signaling (GPCR signaling, Rho signaling, synaptic transmission) and membrane transport processes (endosome-to-lysosome transport, sodium ion transport). While there are some outliers (liver development, ascospore formation), the shared theme is signaling and trafficking at the cellular membrane.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":2},{"id":"GO:1902824","count":1},{"id":"GO:0030437","count":1},{"id":"GO:1902307","count":1},{"id":"GO:1990386","count":1}]},{"hash":"609429809848407817","title":"Developmental apoptosis with immune regulation","description":"Top GO terms cluster around apoptosis (apoptotic DNA fragmentation; germ cell/nurse cell apoptosis) with immune regulation (negative regulation of B cell proliferation; T cell homeostasis) and developmental roles (heart development; platelet formation). This suggests a group of proteins involved in programmed cell death linked to immune development and organogenesis, possibly stress-modulated. No edges, but the common theme is apoptotic/immune development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0006309","count":3},{"id":"GO:0051384","count":3},{"id":"GO:0030889","count":3},{"id":"GO:0043029","count":3},{"id":"GO:0045736","count":3}]},{"hash":"558684193835030880","title":"Immune signaling and cytoskeletal dynamics","description":"This cluster centers on immune-related signaling processes (TLR9 signaling, IL-6 production, T cell costimulation) and processes tied to cell migration and proliferation, with actin filament severing indicating cytoskeletal remodeling essential for movement. While a few terms are broader or peripheral (e.g., FSH signaling, PNS development), the dominant theme is immune activation coupled with cytoskeletal changes that enable cell migration and interactions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051014","count":2},{"id":"GO:0042699","count":1},{"id":"GO:1904237","count":1},{"id":"GO:1904588","count":1},{"id":"GO:0008284","count":1}]},{"hash":"600793200215169773","title":"Plant methionine/SAM cycle and one-carbon metabolism","description":"GO terms center on SAM biosynthesis, L-methionine cycle, and one-carbon metabolism, with related plant biosynthetic processes like anthocyanin and sporopollenin production. This common thread points to core methionine/SAM flux and one-carbon metabolism in plants, with extensions into pigment and pollen-wall biosynthesis.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006556","count":2},{"id":"GO:0009718","count":2},{"id":"GO:0009087","count":1},{"id":"GO:0006730","count":1},{"id":"GO:0033353","count":1}]},{"hash":"1327197018707785528","title":"Unknown","description":"The terms span diverse catabolic processes (lactose, cellulose, glucosinolate) and varied signaling pathways (insulin, cytokinin, paracrine, fever-related prostaglandin signaling) across different biological contexts, with no clear shared function, so a single coherent label isn\u2019t supported.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019512","count":2},{"id":"GO:0090080","count":2},{"id":"GO:0009736","count":2},{"id":"GO:0030245","count":2},{"id":"GO:0019762","count":2}]},{"hash":"510751401496118419","title":"Unknown","description":"The GO terms span photoreceptor maintenance, vascular/vasopressin regulation, temperature response, immune signaling (IL-1\u03b2 production, dendritic cell differentiation), cell proliferation, GPCR/cAMP signaling, coagulation, and sensitization, with no clear single functional theme linking the three proteins. This diversity suggests no coherent cluster-wide function to name beyond Unknown.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045494","count":1},{"id":"GO:0001992","count":1},{"id":"GO:0071502","count":1},{"id":"GO:0032651","count":1},{"id":"GO:0097029","count":1}]},{"hash":"1909872064053376929","title":"Protein quality control and inflammatory signaling","description":"The most represented terms cluster around proteostasis (protein stabilization, chaperone-mediated assembly) and immune/cytokine responses (positive regulation of TNF and IL-6 production). Supporting terms include stress responses (cadmium) and nuclear organization (Cajal body/telomerase related), but these are secondary. The combination suggests a cluster tied to protein homeostasis with inflammatory signaling, hence this label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0052212","count":3},{"id":"GO:1904469","count":3},{"id":"GO:1904871","count":3},{"id":"GO:0050821","count":3},{"id":"GO:0051131","count":3}]},{"hash":"149906485655494584","title":"Unknown","description":"The top terms span immune cytokine regulation (TNF/IL-6), chaperone-mediated protein folding and stabilization, and nuclear processes like Cajal body localization and telomerase maintenance, with no clear unifying theme. Confidence: None","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0052212","count":3},{"id":"GO:1904469","count":3},{"id":"GO:1904871","count":3},{"id":"GO:0050821","count":3},{"id":"GO:0051131","count":3}]},{"hash":"1810892057123550813","title":"Drosophila Developmental Morphogenesis","description":"The terms cluster around developmental processes across multiple tissues (neural axon guidance, muscle attachment, wing vein specification, tubule organization, gland morphogenesis, and muscle regeneration) plus general cellular processes (nuclear import, MAPK regulation). The common theme is broad morphogenesis and tissue differentiation during development, rather than a single cohesive pathway, so a general developmental morphogenesis label fits best.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071679","count":1},{"id":"GO:0043409","count":1},{"id":"GO:0048714","count":1},{"id":"GO:0016203","count":1},{"id":"GO:0034453","count":1}]},{"hash":"521850917406770228","title":"Cholesterol and Sphingolipid Metabolism Regulators","description":"The top GO terms point to cholesterol homeostasis and sphingolipid metabolism, with additional terms related to developmental signaling (MAP kinase regulation and Hedgehog/Smo signaling) and epidermal differentiation. This pattern suggests a cluster of proteins that couple lipid metabolism with modulation of developmental signaling pathways, potentially across species (including insect molting/cuticle processes). ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042632","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0043407","count":2},{"id":"GO:0006665","count":2},{"id":"GO:0021997","count":2}]},{"hash":"1836801853653857620","title":"Ubiquitin-Driven Telomeric Heterochromatin","description":"The cluster\u2019s top GO terms emphasize ubiquitination (free ubiquitin chain polymerization, histone monoubiquitination) and subtelomeric/telomeric heterochromatin formation/maintenance, suggesting a role in ubiquitin-dependent regulation of telomeric chromatin. Some terms are obsolete or unrelated, indicating annotation noise, but the core theme supports a chromatin- and telomere-focused function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010994","count":3},{"id":"GO:0070423","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0010390","count":3},{"id":"GO:0006344","count":3}]},{"hash":"1941638053839690738","title":"Vertebrate organ morphogenesis","description":"The top GO terms point to developmental and morphogenetic processes across multiple organs (multicellular organism development, eye and heart/lung morphogenesis, angiogenesis, ECM remodeling via hyaluronan biosynthesis), indicating proteins are linked to organ formation and tissue patterning rather than a single isolated function. Some terms (interleukin-4 production, cortisol response) may reflect broader regulatory or stress-responsive elements that can accompany development, but the dominant signal is morphogenesis. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:1903672","count":2},{"id":"GO:0060488","count":2},{"id":"GO:2000811","count":2},{"id":"GO:0072602","count":2}]},{"hash":"950830555081594971","title":"Fungal lipid biosynthesis and sterol regulation","description":"The top GO terms are dominated by fungal-specific lipid pathways: mannosyl-inositol phosphorylceramide metabolic process and regulation of ergosterol biosynthesis, plus unsaturated fatty acid biosynthetic process. This suggests a cluster whose proteins participate in membrane lipid production and sterol regulation common to fungi. The other terms (nitric oxide biosynthesis and nitrate assimilation) are broader metabolic processes, but do not redefine the main theme.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006675","count":3},{"id":"GO:0006809","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0006636","count":3},{"id":"GO:0032443","count":3}]},{"hash":"1235581828553105056","title":"Autophagy-lysosome Targeting","description":"The GO terms are all tied to trafficking and degradation via autophagy and lysosomal pathways (cytoplasm-to-vacuole targeting, protein targeting to lysosome, phagophore site localization, and autophagy-related processes), indicating a coherent theme of delivering or degrading cargo through autophagy-lysosome machinery.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":1},{"id":"GO:0032258","count":1},{"id":"GO:0006622","count":1},{"id":"GO:0033299","count":1},{"id":"GO:0034497","count":1}]},{"hash":"749823125814944635","title":"Carbohydrate and Retinoid Metabolism","description":"This cluster includes GO terms tied to carbohydrate pathways (fructose biosynthesis, D-xylulose 5-phosphate biosynthesis, non-phosphorylated glucose catabolism) and to retinoid metabolism (retinol and retinoic acid), suggesting a metabolic group with emphasis on sugar processing and vitamin A turnover, with additional detox-related processes.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046370","count":1},{"id":"GO:0042573","count":1},{"id":"GO:0033859","count":1},{"id":"GO:0019518","count":1},{"id":"GO:0046688","count":1}]},{"hash":"648754641370489621","title":"Glycan biosynthesis and carbohydrate metabolism","description":"GO terms point to a shared focus on carbohydrate-related processes, including glycogen and starch biosynthesis, GPI anchor biosynthesis, and protein glycosylation in the ER, along with a response to sucrose. Although there are notes about bacillithiol and mycothiol biosynthesis (bacterial thiol cofactors), the dominant signal is glycan assembly and carbohydrate metabolism, supporting a label centered on glycan biosynthesis.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007631","count":2},{"id":"GO:0033577","count":2},{"id":"GO:0071793","count":2},{"id":"GO:0019252","count":2},{"id":"GO:0009744","count":2}]},{"hash":"43504466011600705","title":"Skeletal muscle ion transport and T-tubule organization","description":"The top GO terms point to ion handling across membranes (proton, potassium, sodium transport) and calcium import into the sarcoplasmic reticulum, together with T-tubule organization and fiber-type transitions, all central to skeletal muscle excitation-contraction coupling and ion homeostasis. Some terms (stilbene catabolic process, glucocorticoid biosynthetic regulation, cardiac hypertrophy) seem peripheral, but the dominant theme is muscle physiology related to ion transport and SR calcium handling. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":2},{"id":"GO:0031947","count":1},{"id":"GO:0097623","count":1},{"id":"GO:0036376","count":1},{"id":"GO:1903243","count":1}]},{"hash":"1597686820073193689","title":"Ribosome Biogenesis and RNA Methylation","description":"The terms cluster around ribosome assembly and RNA processing/modification: cytosolic ribosome and preribosome assembly, LSU rRNA maturation, rRNA base methylation, and tRNA wobble methylation, plus positive regulation of mitochondrial translation. A couple of terms (transcription regulation, T cell activation, hypoxia) may be peripheral noise rather than core functions of this cluster. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0002127","count":1},{"id":"GO:0070131","count":1}]},{"hash":"1380467102885900233","title":"Developmental transcriptional regulation","description":"The top GO terms center on DNA-templated transcription and developmental regulation, including negative regulation of Notch signaling, and positive regulation of myoblast differentiation and vasculogenesis, suggesting the proteins collectively participate in controlling gene expression during development and tissue formation. Some unrelated terms (hydroxylation, catabolic processes) appear, but the core theme appears to be developmental transcriptional regulation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045746","count":2},{"id":"GO:0061428","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042264","count":2},{"id":"GO:0036138","count":2}]},{"hash":"1951102480426530765","title":"Cofactor Biosynthesis and tRNA Modification","description":"The top GO terms show multiple biosynthetic processes for cofactors (molybdenum cofactor, biotin, lipoate, protoporphyrinogen IX) and several tRNA modification pathways (tRNA modification, tRNA methylation, queuosine biosynthesis). This combination suggests the proteins form a small biosynthesis-focused cluster tied to assembling cofactors and modifying tRNA, rather than a single pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006777","count":2},{"id":"GO:0018339","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0019475","count":1},{"id":"GO:0006400","count":1}]},{"hash":"1055483562982253475","title":"Sugar catabolism cluster","description":"Proteins in this set are linked to carbohydrate catabolic processes and glycerol metabolism (glycerol-3-phosphate biosynthesis and glycerol catabolic process, plus various sugar-specific catabolism pathways like rhamnose, fucose, xylulose, gluconate, and D-gluconate). The dominant pattern is sugar utilization and breakdown, with a few terms (quorum sensing, interleukin-13 response) likely incidental. Overall, the cluster centers on carbohydrate catabolism and energy-yielding metabolism.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":2},{"id":"GO:0046167","count":2},{"id":"GO:0009372","count":2},{"id":"GO:0035963","count":2},{"id":"GO:0019301","count":2}]},{"hash":"1554235389828095233","title":"Embryonic development signaling and muscle differentiation","description":"I chose this name because the GO terms cluster around developmental processes (telencephalon development, multicellular organism development, embryonic epithelial polarity) and muscle formation (myoblast fusion), with several signaling pathways such as erythropoietin signaling, IL-18 signaling, and JNK regulation. While immune-related terms appear, the dominant theme is developmental signaling linked to embryogenesis and muscle differentiation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070233","count":2},{"id":"GO:0038162","count":2},{"id":"GO:0007520","count":2},{"id":"GO:0021537","count":2},{"id":"GO:0045727","count":2}]},{"hash":"1633581961712271000","title":"Photoreceptor and podocyte differentiation regulators","description":"This cluster centers on tissue-specific differentiation, with GO terms highlighting photoreceptor cell differentiation (including camera-type eye photoreceptor differentiation) and nephron/epithelial differentiation (podocyte and glomerular/parietal epithelial cells). Endocytosis regulation terms are present but secondary, so the main theme is eye and kidney epithelial differentiation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045494","count":1},{"id":"GO:0072139","count":1},{"id":"GO:0072112","count":1},{"id":"GO:0060219","count":1},{"id":"GO:2001287","count":1}]},{"hash":"2273143133270946547","title":"ER-Golgi to Plasma Membrane Transport","description":"These proteins are defined by GO terms centered on vesicle transport within the secretory pathway, especially ER-to-Golgi transport and Golgi-to-plasma membrane transport, indicating a primary role in secretory trafficking. A few other terms reference immune signaling or cytoskeletal processes, but the dominant theme is intracellular transport along the ER\u2013Golgi\u2013PM axis.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0090316","count":2},{"id":"GO:0043001","count":2},{"id":"GO:0043124","count":1},{"id":"GO:1902307","count":1}]},{"hash":"333076481317445953","title":"Unknown","description":"These top GO terms cover a broad and disparate set of processes (developmental morphogenesis, sensory perception, cell cycle, mRNA splicing, actin dynamics) with no single predominant function linking the proteins, and the cluster has no edges or meaningful connectivity. Therefore, a specific, representative label cannot be inferred.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0035185","count":2},{"id":"GO:0030042","count":2}]},{"hash":"340298205100807712","title":"Unknown","description":"The listed GO terms span sensory pain detection, synaptic regulation, cell division, telomere maintenance, fat differentiation, and cardiac development, with no clear shared biological theme across the proteins. There are no edges connecting members, and the terms do not converge on a single function, so a coherent label cannot be assigned. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0007253","count":2},{"id":"GO:0032212","count":2}]},{"hash":"1117745822708641583","title":"ER-Golgi trafficking and COPI vesicle formation","description":"The top GO terms are dominated by COPI-coated vesicle budding, COPI coating of Golgi vesicles, Golgi ribbon formation, ER-to-Golgi transport, and ER protein exit, pointing to a shared function in secretory pathway trafficking between the ER and Golgi. Although a few terms seem unrelated (developmental or behavioral terms), the core cluster centers on the ER-Golgi transport system and COPI vesicle dynamics, supporting this label.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902003","count":1},{"id":"GO:0035964","count":1},{"id":"GO:0048205","count":1},{"id":"GO:0090161","count":1},{"id":"GO:0002121","count":1}]},{"hash":"2083851849777977088","title":"Developmental and cellular stress responses","description":"The top GO terms span development (multicellular organism development; neural tube closure), cell proliferation and cycle (mitotic cell cycle; cell population proliferation), ER stress\u2013linked apoptosis (intrinsic apoptotic signaling in response to ER stress), and trafficking (retrograde vesicle-mediated transport, Golgi to ER), plus broad signals like response to nutrient and TGF-beta stimulus and occasional immune defense. This mix suggests a broad regulatory module that links growth, differentiation, and stress responses rather than a single pathway, so the label emphasizes both development and cellular stress regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007584","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0072432","count":3},{"id":"GO:0006890","count":3}]},{"hash":"60356702351658891","title":"Unknown","description":"The top terms span developmental processes, neural development, fertilization, ribosome biogenesis, immune response, and cellular stress, with no clear single functional theme tying all proteins together. This suggests no coherent cluster function can be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1159330800656546497","title":"Ubiquitin-dependent telomeric chromatin regulation","description":"The cluster shows multiple ubiquitin-related and chromatin-silencing terms (histone monoubiquitination, free ubiquitin chain polymerization, subtelomeric heterochromatin formation/maintenance) centered on telomeric regions, suggesting proteins involved in ubiquitin-guided chromatin state and telomere integrity, with some obsolete GO entries indicating historical annotations but supporting the same theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010994","count":3},{"id":"GO:0070423","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0010390","count":3},{"id":"GO:0006344","count":3}]},{"hash":"1077036768670840370","title":"Meiosis and Chromosome Dynamics","description":"The GO terms point to meiotic processes and chromosome management: ascospore formation, meiotic double-strand break repair, kinetochore localization, and DNA damage checkpoint regulation, along with mitotic/meiotic actomyosin ring assembly. While there are some outliers related to EMT, locomotion, T cell homeostasis, and NFAT signaling, the core set centers on meiosis, genome maintenance, and chromosome segregation, suggesting this cluster reflects components of meiotic and chromosomal machinery.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030437","count":3},{"id":"GO:1903501","count":3},{"id":"GO:0031987","count":3},{"id":"GO:0001837","count":3},{"id":"GO:0043029","count":3}]},{"hash":"1425013072300363869","title":"Nuclear transcription and chromatin regulation","description":"The GO terms point to transcription control by RNA polymerase II (regulation and elongation), chromatin organization (rDNA heterochromatin formation), DNA topology changes, and cell-cycle\u2013related processes like chromosome condensation and nuclear movement, suggesting a group of proteins involved in nuclear genome regulation and chromosome dynamics across development and the cell cycle.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":2},{"id":"GO:0040016","count":1},{"id":"GO:0006357","count":1},{"id":"GO:0006271","count":1},{"id":"GO:0032922","count":1}]},{"hash":"1208788388151098433","title":"Nucleotide Metabolism and DNA Maintenance","description":"Based on the GO terms, the proteins are enriched for nucleotide biosynthesis (CDP, ADP, ITP metabolism; purine ribonucleotide interconversion; AMP salvage) and DNA repair, suggesting a core role in nucleotide metabolism and genome maintenance. The presence of broader terms like viral process and developmental processes likely reflects annotation breadth or indirect associations, but the strongest signal centers on nucleotide metabolism and DNA repair.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0046705","count":3},{"id":"GO:0006172","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0046041","count":3}]},{"hash":"401284024038413726","title":"RNA splicing regulation and mRNA processing","description":"The cluster is dominated by GO terms related to RNA processing, especially splicing (regulation of alternative mRNA splicing via spliceosome, negative regulation of mRNA splicing via spliceosome), mRNA modification and stabilization, and parts of ribosome biogenesis (small-subunit processome assembly) and translation reinitiation. Together these point to a core function in RNA processing and post-transcriptional regulation rather than transcription. Blastocyst formation and ncRNA-mediated silencing are contextually related but do not define the cluster as strongly as splicing/metabolism terms. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":1},{"id":"GO:0031047","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0048255","count":1}]},{"hash":"1204732859021307975","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes and regulation of I-kappaB phosphorylation, which are central to NF-\u03baB activation and downstream cytokine production (IL-2/IL-6). This suggests the proteins in this cluster are linked to protein turnover that modulates NF-\u03baB\u2013driven immune signaling, with some additional terms possibly reflecting pleiotropy or non-specific annotations. Overall, a coherent theme is ubiquitin-mediated degradation influencing NF-\u03baB\u2013mediated immune responses.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0070207","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0046529","count":2},{"id":"GO:0030316","count":2}]},{"hash":"2303229850511815916","title":"Nucleotide biosynthesis and metabolism","description":"These proteins are predominantly annotated with nucleotide- and nucleoside-related biosynthetic processes (AMP biosynthesis, hypoxanthine and urate biosynthesis, nucleoside metabolic process, PRPP biosynthesis), suggesting a core theme of nucleotide metabolism. Some terms like fungal-type cell wall organization or bone development may reflect broader or misannotated associations, but the strongest, recurring signal is nucleotide biosynthesis/metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0006167","count":3},{"id":"GO:0031505","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0031100","count":3}]},{"hash":"2074616849438431709","title":"Thermogenesis and Temperature Response","description":"The top GO terms are dominated by cellular response to temperature stimulus and diet-induced thermogenesis, indicating a shared role in heat/temperature-related metabolic regulation. While other terms touch on heart, immune differentiation, and sensory processes, they are less central to the cluster\u2019s main signal. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0043547","count":3}]},{"hash":"491278705641169995","title":"Unknown","description":"The GO terms span metabolism (glucosamine/N-acetylglucosamine, arginine biosynthesis), polyamine catabolism, mycothiol biosynthesis, protein acetylation, sporulation, chromatin-related processes, and plant development, showing no single unifying function for these proteins.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006044","count":1},{"id":"GO:0001525","count":1},{"id":"GO:0006348","count":1},{"id":"GO:2000025","count":1},{"id":"GO:0046208","count":1}]},{"hash":"633098145231933979","title":"Unknown","description":"The GO terms span diverse processes (temperature response, ion transport, sensory perception, development of various organs, immune regulation, and cardiac physiology) with no single clear shared function, so a cohesive, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":2},{"id":"GO:0097623","count":2},{"id":"GO:0050968","count":2},{"id":"GO:0021750","count":2},{"id":"GO:0002724","count":2}]},{"hash":"351206091066537262","title":"Mitotic division and Golgi organization","description":"The top GO terms are dominated by mitotic cell cycle, membrane addition at cytokinesis, and Golgi organization, pointing to a core role in cell division and related membrane trafficking. While there are additional terms related to apoptosis and immune signaling, these are less central to the cluster's predominant signal. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007107","count":2},{"id":"GO:0007030","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0016064","count":2}]},{"hash":"546299463130048552","title":"Zinc Ion Transport and Homeostasis","description":"The cluster is dominated by GO terms related to zinc handling, including zinc ion import across the plasma membrane, intracellular zinc ion homeostasis, detoxification of zinc ion, and cellular response to zinc ion starvation, pointing to a coherent role in zinc uptake and maintenance. Some other terms like pollen tube growth and limb development appear but are likely less central to the core zinc-related function.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903615","count":1},{"id":"GO:0060173","count":1},{"id":"GO:0010312","count":1},{"id":"GO:0006882","count":1},{"id":"GO:0006830","count":1}]},{"hash":"1505962719484190347","title":"Unknown","description":"The top GO terms cover a wide range of unrelated processes\u2014from pain sensing and synaptic regulation to spindle assembly, receptor signaling, telomere maintenance, and various differentiation events in adipose tissue, immune cells, muscle, and heart. There is no clear, cohesive biological theme linking these terms to a single function or pathway for the cluster, so a single descriptive label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0007175","count":2},{"id":"GO:0007253","count":2}]},{"hash":"1414791323975644799","title":"Arabinogalactan protein glycosylation and root hair development","description":"This cluster centers on plant cell surface glycoproteins, especially arabinogalactan proteins (AGPs). The top GO terms emphasize AGP metabolic processes, mucilage biosynthesis in seed coats, root hair development, and related glycosylation pathways (e.g., hydroxyproline O-glycosylation, poly-N-acetyllactosamine). Together these indicate a coherent theme of AGP-related glycosylation shaping cell wall/mucilage production and root hair growth.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":1},{"id":"GO:0048354","count":1},{"id":"GO:0080147","count":1},{"id":"GO:0010405","count":1},{"id":"GO:0010493","count":1}]},{"hash":"1779836048518932488","title":"Unknown","description":"There are no GO terms to connect the proteins; with three proteins and only two edges but no shared functional terms, a cohesive function label cannot be inferred.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]}]