{"hash":"280192932191009223","title":"Ubiquitin-Dependent Proteolysis and Cell Cycle Regulation","description":"The cluster is best characterized by ubiquitin-related regulation (ubiquitin-dependent catabolic process and protein ubiquitination) along with DNA damage response and cell cycle control signals (p53-mediated DDR, mitotic start control point, and apoptosis regulation), suggesting a module focused on protein turnover governing checkpoint signaling and cell cycle progression. Some heart-development terms and methylation annotations appear secondary or incidental to the main theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"NP_741176.2","go_terms":["GO:0032259","GO:0030488"]},{"accession":"NP_509664.1","go_terms":[]},{"accession":"NP_508469.2","go_terms":[]},{"accession":"NP_505552.1","go_terms":[]},{"accession":"NP_001370584.1","go_terms":[]},{"accession":"NP_499250.1","go_terms":["GO:0071494","GO:0071456","GO:0003281","GO:0048096","GO:0006977","GO:0003283","GO:0003139","GO:0003181","GO:0071301","GO:0003203","GO:0000122","GO:0006337","GO:0043044","GO:0003219","GO:0045023","GO:0016567","GO:0043066","GO:1904404","GO:0003407","GO:0007089","GO:0071157","GO:0043518"]},{"accession":"NP_497759.1","go_terms":["GO:0060707","GO:0003323","GO:0060806","GO:0035270","GO:0060972","GO:0060536","GO:0003198"]},{"accession":"NP_497287.2","go_terms":["GO:0001189","GO:1901838"]},{"accession":"NP_495903.1","go_terms":[]},{"accession":"NP_496477.2","go_terms":[]},{"accession":"NP_494007.1","go_terms":["GO:0010216","GO:0036353","GO:0070842","GO:0032088","GO:0006511","GO:0035520","GO:2001200","GO:0043380","GO:1900477","GO:0072156","GO:0042748","GO:0042092","GO:0009638","GO:0007519","GO:0045496","GO:2000176","GO:0048294","GO:0042787","GO:0031397","GO:2000312","GO:0050853","GO:0032764","GO:0048741","GO:0002467","GO:1990390","GO:0009958","GO:0070294","GO:1904431","GO:0045497"]},{"accession":"NP_510701.2","go_terms":["GO:0042692"]},{"accession":"NP_506701.1","go_terms":["GO:0044828","GO:0090114","GO:0006987","GO:0070972","GO:0030968","GO:0006874","GO:0060304","GO:0044791","GO:0044829"]},{"accession":"NP_495655.1","go_terms":["GO:0009826","GO:0018279"]},{"accession":"NP_497412.2","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"NP_505012.2","go_terms":["GO:0009411","GO:0006283"]}],"graph":[],"all_go_terms":{"GO:0032259":1,"GO:0030488":1,"GO:0016567":1,"GO:0071494":1,"GO:0003181":1,"GO:0003219":1,"GO:0006977":1,"GO:0007089":1,"GO:0043066":1,"GO:0045023":1,"GO:0048096":1,"GO:0071456":1,"GO:0071301":1,"GO:0043518":1,"GO:0003407":1,"GO:0003139":1,"GO:0071157":1,"GO:0003283":1,"GO:1904404":1,"GO:0000122":1,"GO:0003203":1,"GO:0006337":1,"GO:0003281":1,"GO:0043044":1,"GO:0003323":1,"GO:0035270":1,"GO:0060707":1,"GO:0060806":1,"GO:0060972":1,"GO:0060536":1,"GO:0003198":1,"GO:0001189":1,"GO:1901838":1,"GO:0050853":1,"GO:0009638":1,"GO:0048741":1,"GO:0042787":2,"GO:0010216":1,"GO:1904431":1,"GO:2000312":1,"GO:0002467":1,"GO:2000176":1,"GO:0070842":1,"GO:0043380":1,"GO:0048294":1,"GO:0045496":1,"GO:0072156":1,"GO:0042748":1,"GO:0035520":1,"GO:0006511":1,"GO:0070294":1,"GO:0032088":1,"GO:1900477":1,"GO:0036353":1,"GO:0045497":1,"GO:0007519":1,"GO:1990390":1,"GO:2001200":1,"GO:0031397":1,"GO:0032764":1,"GO:0042092":1,"GO:0009958":1,"GO:0042692":1,"GO:0090114":1,"GO:0006987":1,"GO:0044828":1,"GO:0006874":1,"GO:0044829":1,"GO:0044791":1,"GO:0070972":1,"GO:0060304":1,"GO:0030968":1,"GO:0018279":1,"GO:0009826":1,"GO:0030174":1,"GO:0046685":1,"GO:0070544":1,"GO:0071276":1,"GO:0000083":1,"GO:1902916":1,"GO:1903378":1,"GO:0031146":1,"GO:0071406":1,"GO:0007057":1,"GO:0021993":1,"GO:0031571":1,"GO:0008285":1,"GO:0000209":1,"GO:0046785":1,"GO:0042752":1,"GO:0051436":1,"GO:0021678":1,"GO:0006516":1,"GO:0060386":1,"GO:0001556":1,"GO:0006283":1,"GO:0009411":1},"recipe_readded":["NP_001021134.1","NP_001368211.1","NP_001021133.1","NP_001366646.1","NP_001255906.1","NP_001359806.1","NP_001021551.1","NP_001379136.1"]}