{"hash":"2097150907329902572","title":"ER stress and unfolded protein response","description":"This cluster features several GO terms tied to proteostasis under stress, including cellular response to unfolded protein, ER stress-induced apoptotic signaling regulation, negative regulation of intrinsic apoptotic signaling in response to hydrogen peroxide, and chaperone/cofactor-dependent protein refolding. Together these point to a coherent theme of ER stress management and unfolded protein response, i.e., maintaining protein folding homeostasis during cellular stress. Some terms like fungal-type beta-glucan biosynthetic process or karyogamy appear unrelated to proteostasis and likely reflect annotation noise or distant homologs, but the dominant signal is proteostasis and stress signaling. Therefore the label ER stress and unfolded protein response is appropriate.","confidence":"Medium","size":8,"edges":11,"triangles":10,"max_degree":5,"top_function":null,"members":[{"accession":"NP_001024913.1","go_terms":["GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"NP_001294715.1","go_terms":[]},{"accession":"NP_001379139.1","go_terms":["GO:0080034","GO:0015991","GO:0006607","GO:0031144","GO:0007301","GO:0048542","GO:0060135","GO:1904501","GO:0060492","GO:0072053","GO:0072054","GO:0003340","GO:0061380","GO:0051561","GO:0060916","GO:0071681","GO:0007050","GO:0031274","GO:0051211","GO:0000011","GO:0098911","GO:0061550","GO:0060066","GO:0010909","GO:0072033","GO:0045110","GO:0043547","GO:2000017","GO:0001840","GO:0016477","GO:0060789","GO:0048096","GO:1904888","GO:0060769","GO:0048496","GO:0042144","GO:0003338","GO:0048364","GO:0021550","GO:1904798","GO:1904793","GO:0070602","GO:0044334","GO:0000281","GO:0044336","GO:0045976","GO:0008285","GO:0071255","GO:0006974","GO:1904948","GO:0086019","GO:0090138","GO:0010172","GO:0007403","GO:0001711","GO:0009833","GO:0072699","GO:0086091","GO:0071562","GO:0032471","GO:0061324","GO:0034333","GO:0016339","GO:0007026","GO:0036023","GO:0030720","GO:0043065","GO:0061198","GO:0032467","GO:0090090","GO:0030997","GO:0022006","GO:0002159","GO:0022009","GO:0035293","GO:0086073","GO:0007398","GO:1990791"]},{"accession":"NP_001367739.1","go_terms":[]},{"accession":"NP_871902.1","go_terms":["GO:0007221","GO:0097190","GO:0001569","GO:0035222","GO:0035321","GO:0048106","GO:0060674","GO:0060412","GO:0007403","GO:0006351"]},{"accession":"NP_001368710.1","go_terms":["GO:0032623","GO:1903044","GO:1901585","GO:0007007","GO:1903905","GO:0000001","GO:0072249","GO:0032226","GO:0022617","GO:0045541","GO:0070584","GO:0032933","GO:0060355","GO:0007588","GO:0052547","GO:1990046","GO:0034141","GO:0030433","GO:0010876","GO:0010918","GO:0090297","GO:0001302","GO:2000049","GO:1900210","GO:0070528","GO:0045861"]},{"accession":"NP_001367460.1","go_terms":[]},{"accession":"NP_491634.1","go_terms":["GO:0006915","GO:0016445"]}],"graph":[["NP_001367739.1","NP_491634.1",0.672],["NP_001367739.1","NP_001367460.1",0.77],["NP_001367739.1","NP_001368710.1",0.821],["NP_001367739.1","NP_001379139.1",0.743],["NP_001367460.1","NP_001024913.1",0.765],["NP_001367460.1","NP_491634.1",0.683],["NP_001367460.1","NP_001368710.1",0.805],["NP_001367460.1","NP_001379139.1",0.631],["NP_001368710.1","NP_491634.1",0.795],["NP_001368710.1","NP_001379139.1",0.818],["NP_001379139.1","NP_491634.1",0.551]],"all_go_terms":{"GO:1903382":1,"GO:1903751":1,"GO:0070880":1,"GO:0090084":1,"GO:0006260":1,"GO:0070389":1,"GO:0000742":1,"GO:0034620":1,"GO:1902037":1,"GO:0016226":1,"GO:0031204":1,"GO:0006616":1,"GO:1900035":1,"GO:0006880":1,"GO:0030720":1,"GO:0072033":1,"GO:0048496":1,"GO:0001840":1,"GO:0007050":1,"GO:1904501":1,"GO:0051561":1,"GO:0031274":1,"GO:0061550":1,"GO:0035293":1,"GO:1990791":1,"GO:0032471":1,"GO:1904793":1,"GO:0045976":1,"GO:0071562":1,"GO:2000017":1,"GO:0061324":1,"GO:0045110":1,"GO:1904888":1,"GO:0048542":1,"GO:0015991":1,"GO:0030997":1,"GO:0022006":1,"GO:0008285":1,"GO:0071255":1,"GO:0031144":1,"GO:0007026":1,"GO:0044334":1,"GO:0080034":1,"GO:0086073":1,"GO:0071681":1,"GO:0000011":1,"GO:0061198":1,"GO:0042144":1,"GO:1904948":1,"GO:0072699":1,"GO:0098911":1,"GO:0072053":1,"GO:0051211":1,"GO:0003340":1,"GO:0060135":1,"GO:0022009":1,"GO:0070602":1,"GO:0007398":1,"GO:0060769":1,"GO:0007301":1,"GO:0043547":1,"GO:0048096":1,"GO:0090138":1,"GO:0016339":1,"GO:0090090":1,"GO:0061380":1,"GO:0009833":1,"GO:0010172":1,"GO:0001711":1,"GO:0002159":1,"GO:0006974":1,"GO:0000281":1,"GO:0086091":1,"GO:0060492":1,"GO:0006607":1,"GO:0036023":1,"GO:0043065":1,"GO:0003338":1,"GO:0072054":1,"GO:0034333":1,"GO:0048364":1,"GO:0060789":1,"GO:0044336":1,"GO:1904798":1,"GO:0010909":1,"GO:0060916":1,"GO:0007403":2,"GO:0021550":1,"GO:0086019":1,"GO:0016477":1,"GO:0032467":1,"GO:0060066":1,"GO:0007221":1,"GO:0097190":1,"GO:0035321":1,"GO:0001569":1,"GO:0060412":1,"GO:0035222":1,"GO:0048106":1,"GO:0060674":1,"GO:0006351":1,"GO:0010918":1,"GO:0034141":1,"GO:0007007":1,"GO:0070528":1,"GO:1903905":1,"GO:2000049":1,"GO:0045861":1,"GO:1990046":1,"GO:0070584":1,"GO:0022617":1,"GO:0000001":1,"GO:0032623":1,"GO:0090297":1,"GO:0032933":1,"GO:0010876":1,"GO:0045541":1,"GO:0001302":1,"GO:0060355":1,"GO:0030433":1,"GO:1900210":1,"GO:0032226":1,"GO:0052547":1,"GO:0072249":1,"GO:1901585":1,"GO:1903044":1,"GO:0007588":1,"GO:0016445":1,"GO:0006915":1},"recipe_readded":["NP_491374.2","NP_508994.1","NP_505573.1","NP_499742.1","NP_510656.1","NP_741525.4","NP_500801.2","NP_497178.1","NP_741422.1","NP_498708.1","NP_492527.1","NP_505819.1","NP_496446.3","NP_491066.1","NP_495750.1","NP_498901.1","NP_499809.1","NP_491633.1","NP_497429.1","NP_501771.1"]}