[{"hash":"1370579086387699168","title":"Cytoskeleton dynamics and cell junctions","description":"The proteins cluster around actin-related processes (actin cortical patch assembly, actin crosslink formation), plus-end directed microtubule sliding, and zonula adherens maintenance, indicating a shared role in cytoskeletal remodeling and cell-cell adhesion. Additional terms like stress granule disassembly and positive regulation of GTPase activity hint at broader signaling and RNA-processing associations, while heart development and long-term synaptic potentiation reflect tissue-specific roles of cytoskeletal dynamics. Overall, the theme is cytoskeletal remodeling linked to cell junctions and intracellular transport.","confidence":"Medium","size":29,"edges":143,"triangles":330,"max_degree":28,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000742","count":6},{"id":"GO:0006919","count":5},{"id":"GO:0000147","count":5},{"id":"GO:0060291","count":4},{"id":"GO:0051764","count":4}]},{"hash":"1609198783530131703","title":"Cell Cycle and Cytoskeletal Dynamics","description":"The terms are dominated by cell division and cell cycle processes (cell division, cell cycle, mitotic cell cycle), with supporting signals for actin filament organization and endocytic recycling, indicating cytoskeletal remodeling and membrane trafficking. Ribosome biogenesis and ribosomal export appear as growth-supporting processes, suggesting coordination between protein synthesis and division. Overall, the cluster seems to capture cell-cycle progression linked with cytoskeletal and trafficking activities, though some terms are peripheral. ","confidence":"Medium","size":29,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000747","count":5},{"id":"GO:0007049","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0051260","count":4}]},{"hash":"795964872924456642","title":"Nuclear transcription and genome maintenance","description":"The top GO terms cluster around nuclear processes: transcription regulation (DNA-templated transcription, SAGA complex localization to transcription regulatory region, mRNA export), chromatin modification (histone deubiquitination), and genome maintenance (double-strand break repair by homologous recombination, trinucleotide repeat maintenance). There are some peripheral terms related to development or lipid biosynthesis, but the dominant theme is nuclear gene expression control and genome integrity. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000724","count":1},{"id":"GO:0040025","count":1},{"id":"GO:0072742","count":1},{"id":"GO:0043248","count":1},{"id":"GO:0035753","count":1}]},{"hash":"1383185742121255570","title":"IRES-Dependent Viral Translation Initiation","description":"Top GO terms point to translation initiation, including reinitiation, preinitiation complex formation, and IRES-dependent viral initiation/termination-reinitiation. This suggests the cluster centers on translation initiation mechanisms, particularly viral or cap-independent initiation, with some accompanying ubiquitination and transcription-related processes likely reflecting regulatory and turnover roles in related pathways.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3}]},{"hash":"1391544371231316476","title":"Ubiquitin-Dependent Proteasomal Degradation","description":"Based on enriched GO terms such as ubiquitin-dependent protein catabolic process, SCF-dependent ubiquitination, and specific ubiquitin linkages (K48, K63, K6), the cluster likely represents components of the ubiquitin-proteasome system driving protein turnover and histone remodeling, with some members involved in antiviral defense signaling. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0051865","count":8},{"id":"GO:0030433","count":8},{"id":"GO:0036205","count":7},{"id":"GO:0031146","count":6}]},{"hash":"707509791292073301","title":"Embryonic organ morphogenesis","description":"The top GO terms cluster around developmental processes across multiple organs during embryogenesis, including heart, eye, hindlimb, placenta, habenula, gonads, and prostate morphogenesis, as well as myoblast proliferation. This points to a shared theme of embryonic organ formation and tissue morphogenesis rather than a single, specific pathway. Therefore, \u201cEmbryonic organ morphogenesis\u201d aptly captures the cluster\u2019s common function.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":20},{"id":"GO:0001890","count":19},{"id":"GO:2000288","count":19},{"id":"GO:0060527","count":19},{"id":"GO:0021986","count":19}]},{"hash":"415046918637137207","title":"Amino acid transport","description":"The top GO terms cluster around amino acid and related small-molecule transport, including L-lysine and L-ornithine import across the plasma membrane, D-serine transmembrane transport, and transepithelial ammonium transport, suggesting a shared function in membrane transport of amino acids and related compounds. Other terms are less representative, but transport signals dominate.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000584","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0060355","count":2},{"id":"GO:0045818","count":1},{"id":"GO:0042942","count":1}]},{"hash":"1017667931989448242","title":"DNA replication and repair with mitotic cell cycle","description":"The top GO terms are dominated by DNA replication, DNA repair, and mitotic cell cycle, indicating a core cluster of nuclear processes governing genome maintenance during cell division. Additional terms like angiogenesis and signaling-related pathways likely reflect multifunctional roles of these proteins or cross-talk with cytoskeletal and receptor signaling, but the strongest signal centers on DNA maintenance and cell cycle progression.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":29},{"id":"GO:0006281","count":28},{"id":"GO:0000278","count":28},{"id":"GO:0001525","count":27},{"id":"GO:0071222","count":27}]},{"hash":"439866835166352258","title":"Developmental signaling and growth factor pathways","description":"These proteins appear linked to multiple signaling cascades (ERK/MAPK, EGFR, PI3K) and development-related processes, including bone formation/remodeling (ossification, osteoclast development), nervous system development, spermatid development, and immune signaling (T cell receptor). The common theme is signaling events that guide cell fate and tissue development across diverse lineages.","confidence":"Medium","size":29,"edges":8,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":7},{"id":"GO:0043931","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0050852","count":6}]},{"hash":"1315084252562860696","title":"Proteostasis & ER-Golgi trafficking","description":"The top GO terms cluster around ubiquitin-dependent proteolysis (ERAD and ubiquitin-dependent protein catabolic process), regulation of ubiquitination, and transport between the endoplasmic reticulum and Golgi, plus related intraflagellar/retromer-like trafficking. This points to a proteostasis-focused cluster centered on protein quality control and vesicle trafficking, with supporting signals from stress responses and signaling regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0060028","count":3}]},{"hash":"1165645752133263896","title":"Glycinergic Neurotransmission and Monoamine Uptake","description":"The cluster is dominated by GO terms tied to glycinergic synaptic transmission and related neurotransmitter handling, including glycine secretion, and uptake of dopamine and serotonin. Although there are a couple of outliers (proline transport, adenohypophysis development), the core signal points to glycinergic neurotransmission and associated monoamine uptake as the shared theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":3},{"id":"GO:0006469","count":3},{"id":"GO:1903346","count":2},{"id":"GO:0060092","count":2},{"id":"GO:0060012","count":2}]},{"hash":"264883359443327432","title":"Unknown","description":"The GO terms are highly diverse, spanning immune development and signaling (angiogenesis, thymus development, activated T cell proliferation, and calcineurin-NFAT regulation), metabolism (cholesterol biosynthesis, insulin signaling), genome maintenance (DNA repair, telomere maintenance), apoptosis, and even a visual learning term, with no clear shared pathway or function tying the proteins together. Additionally, there are no edges or coherent interactions among proteins, suggesting the cluster does not reflect a single cohesive biological process.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0008542","count":5},{"id":"GO:0001525","count":4},{"id":"GO:0048538","count":4},{"id":"GO:0050798","count":4},{"id":"GO:0006915","count":4}]},{"hash":"940479924790353175","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071039","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0007628","count":2},{"id":"GO:0071805","count":2}]},{"hash":"2134953324269498568","title":"AKT/PI3K Signaling and Tyrosine Phosphorylation","description":"This cluster is dominated by GO terms related to kinase signaling, notably activation of AKT and positive regulation of the PI3K/AKT pathway, and tyrosine phosphorylation events including autophosphorylation and STAT phosphorylation. The presence of membrane-targeting and protein phosphorylation terms supports a theme of signaling cascades coordinated at the membrane, with some neural development references (Schwann cell development) that align with signaling roles in neural contexts. Overall, the label captures a cohesive signaling/phosphorylation theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032148","count":3},{"id":"GO:0060045","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0014044","count":3},{"id":"GO:0038083","count":3}]},{"hash":"1893784871224514511","title":"Sex Determination and Gonad Development Signaling","description":"The terms point to sex differentiation and gonad formation (male sex determination, genital disc primordium, female gonad development) and are accompanied by growth-related signaling pathways (IGF receptor signaling, PKC/AKT activation), suggesting a cluster of proteins involved in reproductive development coordinated by growth signaling. While some terms are more general, the prominent theme is sex-specific gonad development linked to signaling pathways.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010951","count":3},{"id":"GO:0035225","count":3},{"id":"GO:0070141","count":3},{"id":"GO:0048009","count":3},{"id":"GO:0060267","count":3}]},{"hash":"255787177812103610","title":"Carbohydrate Metabolism and Xenobiotic Catabolism","description":"Top GO terms indicate primary involvement in carbohydrate metabolic processes (carbohydrate metabolic process, glycogen metabolic process) and xenobiotic/chemical catabolic processes (atrazine and ochratoxin A catabolic processes). While there are also regulatory terms present, the strongest, recurring themes are metabolism and detoxification, suggesting these proteins cluster as metabolic/detoxification actors with supporting regulatory roles.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":2},{"id":"GO:0005977","count":1},{"id":"GO:0043086","count":1},{"id":"GO:0009966","count":1},{"id":"GO:0043666","count":1}]},{"hash":"1130054437304705337","title":"Meiosis I spindle assembly and proteolysis","description":"The cluster\u2019s top GO terms heavily center on meiosis I processes (spindle assembly in female meiosis I, oocyte maturation), microtubule dynamics, and ubiquitin/SCF-dependent proteasomal protein degradation, suggesting a functional module coordinating spindle formation with proteolysis during meiosis. A few terms about neural development appear but are likely incidental to broader developmental roles. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":16},{"id":"GO:0046785","count":16},{"id":"GO:0021678","count":16},{"id":"GO:0021993","count":16},{"id":"GO:0070544","count":16}]},{"hash":"1348937098937861254","title":"Nucleolar RNA Processing and Protein Localization","description":"Top GO terms point to RNA splicing and protein localization to the nucleolus, together with post-translational protein targeting to membranes. These items suggest a theme around RNA processing and nucleolar/trafficking roles within the cell. While other terms (response to heat, face morphogenesis, regulation of EGFR activity) are broader, the shared signals most strongly support a function in nucleolar RNA processing and intracellular protein localization/trafficking. The label is plausible but not definitive given the breadth of terms.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":2},{"id":"GO:0031204","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0060325","count":2},{"id":"GO:0097309","count":2}]},{"hash":"922280137174590081","title":"Vertebrate embryonic development and organ morphogenesis","description":"The top GO terms cluster around embryonic development across multiple organs (brain, pituitary, limbs, skeletal system, heart outflow tract) and morphogenesis, with specific mentions of limb/digit formation and forebrain neuron commitment. This points to a shared theme of developmental programs and tissue patterning rather than a single biochemical pathway. The terms imply proteins regulating gene expression during vertebrate organogenesis and brain/limb morphogenesis. Therefore a concise label emphasizing embryonic development and organ morphogenesis best captures the cluster.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0023019","count":6},{"id":"GO:0003148","count":6}]},{"hash":"942819144947332656","title":"Diversified Catabolic Metabolism","description":"This cluster is dominated by GO terms for the breakdown of a wide range of compounds (beta-ketoadipate, uracil, triglycerides, chlorophyll, alkaloids, xenobiotics) and detoxification, plus related biosynthetic and regulatory processes. The common theme is broad catabolic metabolism and detox pathways rather than a single, cohesive pathway.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0098869","count":13},{"id":"GO:0042952","count":10},{"id":"GO:0006212","count":10},{"id":"GO:2000124","count":10},{"id":"GO:0019433","count":10}]},{"hash":"2285252841755686754","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2}]},{"hash":"958009860212100101","title":"Antiviral innate immune response","description":"This cluster is dominated by GO terms related to antiviral defense and innate signaling, including response to exogenous dsRNA, interferon-beta production, innate immune and inflammatory responses, regulatory roles in dendritic cell cytokine production, and the Toll-like receptor 4 signaling pathway. These collectively point to proteins involved in sensing viral components and driving interferon-mediated inflammatory responses.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0006954","count":5},{"id":"GO:1902499","count":3},{"id":"GO:0045359","count":3},{"id":"GO:0043330","count":3}]},{"hash":"1526356619818121951","title":"Chemosensory Olfactory Response","description":"This cluster is dominated by GO terms related to detection and perception of chemical stimuli and olfactory behavior, suggesting a chemosensory/olfactory function among the proteins. Acknowledging that a few developmental terms appear among the top terms, the chemosensory theme is the clearest common thread.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":6},{"id":"GO:0071230","count":2},{"id":"GO:0040027","count":2},{"id":"GO:0007606","count":2},{"id":"GO:0042048","count":2}]},{"hash":"171196500651085266","title":"Cerebellar development and ER calcium homeostasis","description":"The top GO terms include cerebellar Purkinje cell differentiation and cerebellar granular layer development, plus endoplasmic reticulum calcium ion homeostasis and negative regulation of calcium transport into cytosol. This points to a cluster of proteins involved in cerebellar neural differentiation with a focus on calcium signaling via the ER, hence the label.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010523","count":1},{"id":"GO:1903298","count":1},{"id":"GO:1904721","count":1},{"id":"GO:0021702","count":1},{"id":"GO:0090005","count":1}]},{"hash":"238744671478129277","title":"Developmental transcription and cell cycle regulation","description":"The terms point to core transcriptional control (DNA-templated transcription) and DNA replication with mitotic cell cycle, while developmental terms like forebrain development and skeletal system development suggest a role in developmental programs. The presence of apoptotic and ER-stress\u2013related signaling indicates stress-responsive regulation that can intersect these processes. Together, they support a label focusing on developmental transcription coupled with cell-cycle control, with some stress responses.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006351","count":25},{"id":"GO:0000278","count":25},{"id":"GO:0006260","count":25},{"id":"GO:0006915","count":25},{"id":"GO:0071276","count":24}]},{"hash":"2046102117518422670","title":"Unknown","description":"The top terms span insect reproductive behavior (egg-laying regulation, post-mating receptivity) and various neural and metabolic processes (larval movement, behavioral defense, signaling pathways, electron transport, interneuron migration) with no apparent single functional theme or interactions among the proteins. A cohesive, specific label cannot be inferred from these terms.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048042","count":9},{"id":"GO:0045434","count":9},{"id":"GO:0008345","count":9},{"id":"GO:0002209","count":9},{"id":"GO:1901045","count":9}]},{"hash":"1489978250407477709","title":"Chromatin modification and gene expression regulation","description":"Top terms indicate histone acetylation/deacetylation and other chromatin modification processes, coupled with development and broad gene expression regulation. The inclusion of SCF-dependent ubiquitin-proteasomal degradation and translation reinitiation suggests interplay between protein turnover/translation control and transcriptional regulation. This points to a cluster centered on epigenetic regulation of transcription and related expression programs.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006349","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0043981","count":3},{"id":"GO:0016575","count":3}]},{"hash":"960545352936531611","title":"Unknown","description":"The top terms cover ubiquitin-dependent proteolysis, RNA decay, immune signaling, and unrelated processes like phototropism and muscle development, indicating no single shared function across the cluster. The lack of edges and the diverse annotations suggest a heterogeneous set rather than a coherent pathway.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0070481","count":2},{"id":"GO:0070651","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0009638","count":2}]},{"hash":"664405249424596918","title":"Apoptosis and neural development","description":"The cluster is enriched for apoptotic-related terms (apoptotic process; recognition of apoptotic cell) alongside neural development and synaptic remodeling terms (CNS development; positive regulation of synapse assembly; collateral sprouting), suggesting a theme around programmed cell death intersecting with neural differentiation and connectivity. Some terms like aminophospholipid transport may relate to membrane changes during apoptosis and clearance, supporting a cohesive, if broad, developmental/death-related neural function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":7},{"id":"GO:0043654","count":5},{"id":"GO:0015917","count":5},{"id":"GO:0043278","count":3},{"id":"GO:0001525","count":3}]},{"hash":"1281180614177924040","title":"Retinoid and Prostaglandin Lipid Metabolism","description":"The cluster is dominated by retinal and retinol metabolic processes (both 16 occurrences) and prostaglandin biosynthesis (11), indicating a core theme of retinoid and lipid signaling pathways. While there are other terms related to redox signaling and miscellaneous processes, the strongest and most frequent terms center on retinoid metabolism and prostaglandin synthesis, suggesting a cohesive lipid-metabolism-focused cluster with retinoids as a primary axis.","confidence":"Medium","size":28,"edges":40,"triangles":16,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":16},{"id":"GO:0042572","count":16},{"id":"GO:0001516","count":11},{"id":"GO:0055114","count":11},{"id":"GO:0048661","count":10}]},{"hash":"2006775145452753080","title":"Neural development and cell signaling","description":"This cluster centers on signaling pathways that drive neural development (hippocampus development, regulation of axonogenesis) and propagate signals (ephrin receptor signaling, JNK/MAPK cascades), with accompanying cytoskeletal remodeling (actin cytoskeleton reorganization) and protein stability regulation. A few terms point to immune signaling (T cell receptor pathway, mast cell degranulation), suggesting broader cell-communication roles. Overall, it reflects proteins involved in neural development and general cell signaling dynamics.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":13},{"id":"GO:0021766","count":12},{"id":"GO:0031532","count":12},{"id":"GO:0050771","count":12},{"id":"GO:0043552","count":12}]},{"hash":"1112857299820495750","title":"RNA processing and translation regulation","description":"The top terms cluster around post-transcriptional RNA handling\u2014mRNA export, modification, stability, and splicing regulation\u2014along with translation initiation/reinitiation and miRNA-mediated silencing, indicating proteins involved in RNA metabolism and control of gene expression at the translational level.","confidence":"High","size":28,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0075522","count":3},{"id":"GO:1902625","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001825","count":2},{"id":"GO:0010610","count":2}]},{"hash":"1465878840762622876","title":"Actin Filament Organization and Bundling","description":"Top GO terms indicate a strong emphasis on actin cytoskeleton processes (actin crosslink formation, actin filament bundle assembly, microspike assembly) with supporting roles in transcytosis and signaling regulation. The predominant theme across the cluster is actin filament organization and bundling, suggesting proteins involved in remodeling the actin cytoskeleton to facilitate cell shape, movement, and cargo transport. Confidence: High","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051764","count":3},{"id":"GO:1904706","count":2},{"id":"GO:0043407","count":2},{"id":"GO:0051661","count":2},{"id":"GO:0060325","count":2}]},{"hash":"1122679040362814665","title":"Plant cell wall synthesis and plasmodesmata organization","description":"The GO terms emphasize plant-type cell wall modification, cellulose biosynthesis regulation, and plasmodesma organization, indicating a cluster centered on plant cell wall construction and intercellular transport; the presence of some non-plant terms suggests annotation heterogeneity.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":4},{"id":"GO:2001009","count":4},{"id":"GO:0009663","count":4},{"id":"GO:0010125","count":4},{"id":"GO:0001525","count":3}]},{"hash":"599502610240072810","title":"Cardiac development and GPCR signaling","description":"The top terms cluster around heart development, secondary heart field specification, and cardiac muscle contraction, indicating a cardiac/heart development theme. Additionally, multiple GPCR-related pathways are present (tachykinin and acetylcholine receptor signaling, GPCR desensitization and internalization, and related phosphorylation), suggesting regulation of GPCR signaling in cardiac contexts. This combination points to a cluster of proteins involved in heart development and GPCR-mediated cardiac signaling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0045444","count":4},{"id":"GO:0007217","count":3},{"id":"GO:0002029","count":3},{"id":"GO:0007213","count":3}]},{"hash":"2047633772838686251","title":"Unknown","description":"The top GO terms span innate immune sensing (TLR1 signaling, detection of lipopeptide), cytoskeletal remodeling (actin filament severing), chromatin localization, developmental polarity, cell cycle regulation, kidney size, and neuronal signaling, showing no single cohesive function tying the cluster together. Therefore no specific, representative label can be assigned.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031030","count":2},{"id":"GO:0035564","count":2},{"id":"GO:0071287","count":2},{"id":"GO:0070340","count":2},{"id":"GO:0051014","count":2}]},{"hash":"1203020084342364242","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000472","count":5},{"id":"GO:0000447","count":5},{"id":"GO:1904263","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0000480","count":5}]},{"hash":"96121216924357265","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036010","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0010570","count":2},{"id":"GO:0044088","count":2},{"id":"GO:0070863","count":2}]},{"hash":"1526016213314559507","title":"Ubiquitin-regulated immune signaling","description":"This cluster is dominated by ubiquitin-related regulation and immune signaling: K11-linked ubiquitination, proteasomal degradation, and modulation of JNK and NF-kappaB pathways. The defense response to Gram-positive bacteria supports an innate-immune module with transcriptional outputs that tie into development, while some terms may reflect broader gene functions beyond immunity.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0070979","count":2},{"id":"GO:0046329","count":2}]},{"hash":"358765442067790468","title":"Developmental processes and cytoskeletal dynamics","description":"These proteins are linked to both developmental events (blastocyst formation, oocyte development, hair follicle maturation) and core cellular mechanics (mitotic spindle assembly, chromosome condensation, actin bundle transport, microspike assembly). The combination points to a broader role in developmental growth coupled with cytoskeletal remodeling and chromosome dynamics, rather than a single narrow function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0048599","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0007076","count":2}]},{"hash":"2094981097288726336","title":"Drosophila neural development and signaling","description":"The top GO terms point to neural development features (peripheral nervous system development, clustering of voltage-gated sodium channels, and cell adhesion) alongside multiple signaling pathways (positive regulation of STAT phosphorylation, IGF receptor signaling) and developmental processes, including some Drosophila-specific contexts (genital disc primordium) and stress responses (UV-A) and apoptosis. This combination suggests a cluster enriched for neural development and associated signaling rather than a single narrow function, hence the label.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042523","count":3},{"id":"GO:0007422","count":3},{"id":"GO:0007155","count":2},{"id":"GO:0045162","count":2},{"id":"GO:0043654","count":2}]},{"hash":"1366666050413306678","title":"Neuronal Synaptic Signaling and Receptor Trafficking","description":"The terms indicate a focus on neural communication, with learning and positive regulation of glutamatergic synaptic transmission, along with receptor internalization, pointing to synaptic signaling and receptor trafficking. Some items (e.g., diacylglycerol catabolic process, LDL particle remodeling) are less clearly connected and may reflect broader lipid signaling or annotation noise. Overall, the cluster is best captured by neuronal signaling and receptor dynamics.","confidence":"Medium","size":27,"edges":18,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042136","count":2},{"id":"GO:0007612","count":2},{"id":"GO:0046340","count":2},{"id":"GO:0031623","count":2},{"id":"GO:0008285","count":2}]},{"hash":"1884862786143735645","title":"ECM Adhesion and Proteostasis","description":"Based on top GO terms, the proteins cluster around integrin signaling, cell-matrix adhesion, and regulation of extracellular matrix assembly, together with ubiquitin-dependent protein degradation and proteasome assembly. While immune-related terms (T cell activation and blood coagulation) appear, the core theme is adhesion/matrix interactions plus protein turnover, which justifies labeling as ECM adhesion and proteostasis.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:0043248","count":2},{"id":"GO:0006929","count":2},{"id":"GO:0070208","count":2},{"id":"GO:1901202","count":2}]},{"hash":"549050748769033511","title":"Immune Receptor Signaling & Ubiquitination","description":"Proteins in this cluster are enriched for stimulatory C-type lectin receptor signaling, T cell and Fc-epsilon receptor signaling, and related NF-kappaB activities, pointing to a core theme of immune receptor signaling. The concurrent presence of ubiquitin-related processes (ubiquitin-dependent ERAD, protein autoubiquitination) suggests strong regulatory control of signaling through ubiquitination and protein quality control, with apoptosis represented as a downstream outcome. Some terms like chromatin/neuronal development appear as outliers, but the dominant pattern supports a cluster centered on immune signaling tightly regulated by ubiquitin pathways.","confidence":"High","size":27,"edges":147,"triangles":493,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002223","count":13},{"id":"GO:0030433","count":10},{"id":"GO:0051865","count":10},{"id":"GO:0050852","count":10},{"id":"GO:0070911","count":10}]},{"hash":"426250828708359000","title":"Neuro-immune signaling and synaptic plasticity","description":"The terms point to neural development and plasticity (axonogenesis, synapse assembly, long-term potentiation) alongside innate immune processes (innate immune response, LPS response, defense against Gram-positive bacteria, dsRNA response). This suggests a cluster of proteins involved in neural wiring and signaling that also participate in immune signaling or neuroimmune cross-talk. Because the cluster spans both neural and immune functions rather than a single, tight pathway, the label captures the core theme with moderate confidence.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0031532","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0007409","count":2}]},{"hash":"1937766665873692076","title":"ER Stress Response and Protein Folding Regulation","description":"This cluster is enriched for terms related to endoplasmic reticulum stress and the unfolded protein response, including negative regulation of ER stress\u2013induced apoptotic signaling and responses to unfolded protein. It also references chaperone-related refolding and proteostasis, supporting a core theme around ER stress signaling and protein folding. Some terms (e.g., fungal beta-glucan biosynthesis, karyogamy) appear unrelated, likely reflecting mixed annotations.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903382","count":2},{"id":"GO:1903751","count":2},{"id":"GO:0070880","count":2},{"id":"GO:0000902","count":2},{"id":"GO:0090084","count":2}]},{"hash":"2046538436506305004","title":"RNA Splicing and mRNA Processing","description":"Most frequent terms point to RNA processing/splicing and post-transcriptional regulation (spliceosomal tri-snRNP assembly, RNA splicing, mRNA processing, translation reinitiation, and mRNA stability in stress). While a few terms discuss development or signaling, the core cluster centers on RNA processing machinery and related regulation.","confidence":"High","size":27,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0000244","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0008380","count":2},{"id":"GO:0033146","count":2}]},{"hash":"83346557351430797","title":"Post-transcriptional gene regulation","description":"The proteins cluster around RNA fate control, with terms for miRNA-mediated silencing, translation initiation/reinitiation, mRNA export, splicing regulation, mRNA modification, and stress-responsive mRNA stability. This points to a cohesive role in post-transcriptional regulation of gene expression, spanning RNA processing, export, and translation, including IRES-driven initiation.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0035278","count":4},{"id":"GO:1902625","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0010610","count":3}]},{"hash":"969693750439787696","title":"Mitochondrial Translation and Intermembrane Import","description":"Most frequent terms point to mitochondrial protein synthesis and import: translation, mitochondrial intermembrane space protein import, and mitochondrial translation termination, plus regulation of respiration. This suggests the cluster is centered on mitochondrial ribosomes and the assembly/import of mitochondrial proteins. A few other terms (stress granule disassembly, chromatin-related processes) are less connected and may reflect broader cellular context or incidental annotations.","confidence":"Medium","size":27,"edges":38,"triangles":8,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0001824","count":2},{"id":"GO:0045041","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0070126","count":2}]},{"hash":"2148076915912181621","title":"ER export and apoptotic regulation during oogenesis","description":"The terms cluster around ER protein export/retention and vesicle trafficking (ER lumen retention, COPI-coated vesicle budding, positive regulation of protein exit from ER, aminophospholipid transport) alongside apoptosis and development signals (apoptotic process, recognition of apoptotic cell, maternal axis specification, egg-laying regulation, placenta development, amyloid-beta regulation). This pattern points to a functional module linking secretory pathway dynamics with apoptotic and developmental processes during oogenesis and early development.","confidence":"High","size":27,"edges":84,"triangles":73,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0043654","count":12},{"id":"GO:0015917","count":12},{"id":"GO:0006915","count":12},{"id":"GO:0006621","count":2},{"id":"GO:0035964","count":2}]},{"hash":"2002911966174949805","title":"Cytoskeletal Dynamics and Cell Polarity","description":"The top GO terms point to actin filament bundle assembly, cell migration, and establishment of epithelial cell polarity, indicating this cluster centers on cytoskeletal remodeling and changes in cell shape/movement. Other terms like skeletal muscle regeneration and cerebellar development also involve cytoskeletal dynamics during growth and differentiation, supporting a broader theme of structural organization and movement. While there are some signaling and tissue-specific terms, the prevailing connection is cytoskeletal dynamics driving cell polarity and motility.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0016477","count":4},{"id":"GO:2001275","count":3}]},{"hash":"1048565890910321689","title":"Endocannabinoid-linked lipid catabolism","description":"This cluster is dominated by GO terms for lipid breakdown (triglyceride, monoacylglycerol, phosphatidylserine catabolism) and regulation of endocannabinoid signaling, suggesting a core theme around lipid metabolism and signaling. While other terms hint at immune or plant-related processes, the strongest shared function appears to be lipid catabolism linked to endocannabinoid pathways. Confidence is moderate due to some heterogeneous terms.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000124","count":4},{"id":"GO:0019433","count":4},{"id":"GO:0006660","count":3},{"id":"GO:0052651","count":3},{"id":"GO:0008285","count":2}]},{"hash":"2202871812189552165","title":"Rho/Rap GTPase Signaling and Trafficking","description":"The enriched terms point to activation and signaling of Rho/Rap GTPases, with accompanying intracellular transport, receptor clustering, and epithelial polarity establishment, suggesting a functional theme around GTPase-driven cytoskeletal organization and membrane trafficking. Ubiquitin-dependent protein turnover and transcription appear as secondary processes but do not define the core theme.","confidence":"High","size":27,"edges":5,"triangles":0,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0090630","count":3},{"id":"GO:0006886","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0008344","count":2}]},{"hash":"206895610311349590","title":"Prostaglandin Biosynthesis and Inflammatory Regulation","description":"Prostaglandin biosynthesis is the dominant function in this cluster (GO:0001516, 23), indicating production of lipid mediators that drive inflammatory signaling. Supporting terms point to modulation of inflammation and redox balance, including negative regulation of TNF production and NOS biosynthesis, cellular oxidant detoxification, and response to ascorbic acid. Additional terms about growth, regeneration, and toxin catabolism suggest broader tissue remodeling and stress responses linked to inflammatory signaling. Overall, the cluster appears centered on prostaglandin-mediated inflammation with accompanying oxidative stress regulation.","confidence":"Medium","size":27,"edges":23,"triangles":0,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":23},{"id":"GO:0098869","count":20},{"id":"GO:2000255","count":20},{"id":"GO:0051771","count":20},{"id":"GO:0032720","count":20}]},{"hash":"2068910548119220796","title":"Neuronal development and synapse formation","description":"The cluster is enriched for neural-related terms: neuroblast proliferation, transmission of nerve impulse, and dendritic spine morphogenesis, along with cell junction maintenance and polarity. While some terms pertain to broader developmental processes (e.g., embryonic skeletal development, sex determination), the dominant signal centers on neural development, connectivity, and synaptic organization.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0048706","count":2},{"id":"GO:0002052","count":2},{"id":"GO:0030238","count":2},{"id":"GO:0019226","count":2}]},{"hash":"527650400693835541","title":"Cartilage Development and ECM Remodeling","description":"The cluster shows enrichment for cartilage development and endochondral ossification, along with collagen fibril organization and collagen catabolic processes, pointing to a shared function in skeletal extracellular matrix formation and remodeling. Other terms such as integrin biosynthesis and podocyte development may reflect related ECM interactions but do not contradict the cartilage/bone theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3},{"id":"GO:0045112","count":3}]},{"hash":"1211338132118206904","title":"Negative regulation of pro-inflammatory cytokine production","description":"Cluster appears to be driven by terms that downregulate cytokine production (IL-6, TNF, IL-1\u03b2), NF-kappaB signaling, and responses to lipopolysaccharide, indicating a common role in dampening inflammatory immune signaling and modulating host defense.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900165","count":2},{"id":"GO:0071222","count":1},{"id":"GO:1903003","count":1},{"id":"GO:1902714","count":1},{"id":"GO:1900261","count":1}]},{"hash":"1700536225197870581","title":"Organogenesis Across Tissues","description":"The top GO terms cluster around developmental processes across multiple organs (nervous system, heart, skeletal muscle, eye/visual system, placenta, pharyngeal system), suggesting organogenesis and tissue development as the shared theme. Some terms reflect general cellular maintenance, but the dominant signal is developmental biology.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0019233","count":4}]},{"hash":"241080339947114591","title":"Metanephric nephron morphogenesis","description":"The top GO terms are dominated by metanephric development and tubule morphogenesis (proximal/distal tubules, ascending limb), indicating the cluster largely represents metanephric kidney nephron morphogenesis. Immune-related terms appear but are far less represented, suggesting they are incidental to a primary kidney development signature.","confidence":"High","size":27,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":17},{"id":"GO:0072237","count":17},{"id":"GO:0036303","count":17},{"id":"GO:0072287","count":17},{"id":"GO:0002223","count":17}]},{"hash":"631795391028288307","title":"Transmembrane Transporters","description":"The GO terms point to a cohesive theme of transport across membranes, spanning ions (sodium, phosphate), sugars and vitamins, various nutrients and xenobiotics, plus vesicular loading of neurotransmitters, all indicating transporter functions or transporter-associated roles.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:1900754","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015751","count":3},{"id":"GO:0015706","count":3}]},{"hash":"324528896628932396","title":"Nematode neural development and molting","description":"The cluster is enriched for nematode-specific processes such as the molting cycle and pharyngeal pumping, alongside neural development and signaling terms (axon extension, guidance, fasciculation, and synaptic plasticity). This combination points to a cohesive set of nematode proteins involved in development and neuromuscular signaling, potentially linking cuticle formation with nervous system maturation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0018996","count":6},{"id":"GO:0043050","count":5},{"id":"GO:0006469","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006627","count":3}]},{"hash":"821054290788551732","title":"DNA damage response and oxidative stress","description":"This cluster is enriched for terms related to managing DNA damage (base-excision repair, DNA recombination) and cellular decisions after damage (apoptosis), as well as oxidative stress signaling (cellular response to hydrogen peroxide). Some terms are obsolete, but the core pattern suggests a cohesive damage-response module that also touches lipid signaling (phosphatidylinositol dephosphorylation) and cAMP responsiveness, likely representing stress-response cross-talk.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046856","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0070301","count":4},{"id":"GO:0044179","count":4},{"id":"GO:0006284","count":4}]},{"hash":"224080138367524426","title":"Unknown","description":"The Top Terms are very diverse and span cell cycle regulation, immune cell differentiation, eye development/visual perception, intracellular trafficking (endosome to melanosome transport and receptor internalization), neuronal junctions, and VEGF signaling. With no shared, cohesive function and no edges connecting proteins, there is no clear theme tying the cluster together. Thus a specific functional label cannot be assigned with confidence.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":1},{"id":"GO:0002318","count":1},{"id":"GO:2000495","count":1},{"id":"GO:0035646","count":1},{"id":"GO:0007601","count":1}]},{"hash":"1736916207532018649","title":"Immune Activation and B Cell Signaling","description":"Based on the GO terms, the cluster is enriched for innate and adaptive immune processes, including innate immune response, defense against Gram-negative bacteria, B cell receptor signaling, and germinal center formation, indicating a cohesive theme of immune activation and humoral immune functions. Ubiquitin-dependent protein catabolic process also aligns with antigen processing and signaling turnover in immunity. Some terms (e.g., phototropism, skeletal muscle development) appear peripheral and likely reflect noise, but the core signal remains immune-related.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0050829","count":2},{"id":"GO:0050853","count":2}]},{"hash":"209207559300167835","title":"Olfactory Chemosensation and Monoaminergic Signaling","description":"A strong emphasis on olfactory behavior and detection of chemical stimuli indicates a chemosensory function. The presence of monoaminergic signaling pathways (dopamine, octopamine/tyramine, norepinephrine) and related cardiovascular terms suggests neural signaling mediated by monoamines. Some GO terms (electron transport chain, cell proliferation) appear less connected and may reflect ancillary protein roles or broader cellular processes. Overall, the cluster appears to represent olfactory chemosensation-linked neurotransmission.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042048","count":11},{"id":"GO:0050907","count":11},{"id":"GO:0031635","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0002025","count":5}]},{"hash":"864409642323023185","title":"Vertebrate Embryogenesis and Tissue Morphogenesis","description":"Most terms describe embryonic development and morphogenesis across multiple tissues (lung, limb, somite, neural crest, spinal cord, gut), suggesting a cohesive role in organogenesis. While a couple terms touch on immune differentiation or autoprocessing, they appear peripheral to the main developmental theme. This supports labeling the cluster as vertebrate embryogenesis and tissue morphogenesis.","confidence":"High","size":26,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060463","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0045445","count":3},{"id":"GO:0048557","count":3},{"id":"GO:0060174","count":3}]},{"hash":"2222853681098785652","title":"Post-transcriptional RNA processing and translational control","description":"The cluster\u2019s top GO terms point to RNA metabolism and gene expression regulation outside transcription: mRNA export, modification, splicing regulation, stability in stress response, translation reinitiation, and miRNA- or IRES-mediated translation control. Together these indicate a cohesive theme of post-transcriptional processing and control of translation, rather than a single signaling pathway or cellular process. Confidence: High","confidence":"","size":26,"edges":210,"triangles":748,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1902625","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0001825","count":5},{"id":"GO:0010610","count":5},{"id":"GO:1903586","count":5}]},{"hash":"523964346799735843","title":"ECM remodeling and cell adhesion signaling","description":"This cluster centers on extracellular matrix interactions and remodeling, with GO terms for matrix assembly regulation, metallopeptidase activity, hyaluronan metabolism, integrin-mediated signaling, and cell-matrix adhesion, as well as related cell migration. While it also includes immune and coagulation references, the dominant theme is ECM remodeling and cell adhesion signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070208","count":6},{"id":"GO:0031104","count":6},{"id":"GO:0007229","count":5},{"id":"GO:0006929","count":5},{"id":"GO:1901202","count":5}]},{"hash":"106237612773474133","title":"RNA processing and post-transcriptional regulation","description":"This cluster is dominated by GO terms related to mRNA stability, splicing, export, modification, and translation regulation, indicating a cohesive group of proteins involved in RNA metabolism and post-transcriptional control, especially in stress contexts.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":15},{"id":"GO:0031047","count":14},{"id":"GO:0048026","count":13},{"id":"GO:0006378","count":11},{"id":"GO:1902625","count":10}]},{"hash":"2175236038077687627","title":"Chloroplast transcription and light response","description":"The cluster is dominated by GO terms for chloroplast organization and response to high light intensity, plus DNA-templated transcription, suggesting a core role in chloroplast gene expression and light-regulated processes; the presence of several development terms likely reflects annotation noise, so this label should be used with moderate confidence.","confidence":"Medium","size":26,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009644","count":2},{"id":"GO:0009658","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0031016","count":2},{"id":"GO:0007492","count":2}]},{"hash":"694528515998407068","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000463","count":11},{"id":"GO:0000462","count":10},{"id":"GO:0000466","count":10},{"id":"GO:0000398","count":9},{"id":"GO:0042273","count":9}]},{"hash":"2250006580953780057","title":"Diverse metabolite biosynthesis","description":"This cluster is dominated by GO terms describing biosynthetic processes for a wide range of small molecules and metabolites (antibiotics, vitamins, steroids, pigments, and alkaloids), suggesting enzymes involved in diverse biosynthetic pathways across different contexts. The central theme is production of varied metabolites, with a few outliers (e.g., lung development) that are less representative. Confidence: High","confidence":"","size":26,"edges":104,"triangles":109,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":14},{"id":"GO:0055114","count":13},{"id":"GO:0042376","count":10},{"id":"GO:0030324","count":10},{"id":"GO:0042619","count":10}]},{"hash":"681977343936835452","title":"Embryonic organogenesis and placental development","description":"The top GO terms cluster around embryonic development processes, especially placental formation (trophoblast giant cell differentiation, placental development) and endocrine/organogenesis pathways, with supporting terms like left-right patterning, cartilage morphogenesis, and EMT in heart cushion formation. This suggests a cohesive theme of embryonic organ development with a placental emphasis, despite some broader signaling terms.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060707","count":2}]},{"hash":"543928243388780350","title":"Neural signaling and sensory processing","description":"This cluster centers on neural signaling and sensory processing, with GO terms for serotonin receptor signaling and dopamine secretion pointing to neurotransmission; sensory processing and cochlea development indicate auditory and multisensory processing; and ion transport terms like sodium and chloride transmembrane transport reflect neuronal ion channels, tying the cluster to neural signaling and sensory transduction.","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002087","count":12},{"id":"GO:0007210","count":11},{"id":"GO:0035725","count":11},{"id":"GO:0043200","count":11},{"id":"GO:0050893","count":11}]},{"hash":"419278841904479273","title":"Nervous System Development and Axon Guidance","description":"The cluster is dominated by nervous system development terms (nervous system development, SMO/SHH signaling, Roundabout signaling) and axon-related processes such as paranode localization and myelination, along with Rho-mediated cytoskeletal regulation, pointing to a neuronal development and axon guidance module. Some non-neural terms (kidney development, salivary gland boundary specification) appear but do not override the central neural theme.","confidence":"High","size":26,"edges":271,"triangles":1551,"max_degree":25,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001822","count":10},{"id":"GO:0007224","count":10},{"id":"GO:0035385","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0050852","count":9}]},{"hash":"1301567079042958207","title":"Mitotic division and Golgi-ER trafficking","description":"The cluster emphasizes mitotic processes (mitotic spindle assembly, cell division) paired with vesicle trafficking between the Golgi and ER (and to/from the plasma membrane), suggesting proteins involved in coordinated cell cycle control and intracellular transport, with developmental terms (heart/skeletal) hinting at broader developmental contexts. This points to a theme around cell division coupled with secretory pathway functions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0007224","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1892181657581204828","title":"Gene Expression and Translation Regulation","description":"These proteins cluster around core gene expression processes: RNA splicing, transcription, ribosome biogenesis, and translation initiation, plus epigenetic modulation (H3-K79 methylation), protein turnover (ubiquitination and APC-dependent degradation), and growth-related signaling (TORC1). Together, they point to coordinated control of gene expression, ribosome assembly, and proteostasis, linked to cell growth and division.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":7},{"id":"GO:0002188","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0001731","count":7}]},{"hash":"2177694981405250266","title":"Cartilage development and ECM remodeling","description":"The top GO terms cluster around cartilage formation and skeletal development (cartilage development involved in endochondral ossification, endochondral ossification), along with collagen fibril organization and collagen catabolic processes, and integrin biosynthesis\u2014all pointing to extracellular matrix (ECM) organization and remodeling during skeletal development. Other related terms (podocyte development, PDGF signaling regulation) further reflect ECM interactions and tissue morphogenesis. This collectively suggests a cohesive role in ECM-mediated cartilage/bone development.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":13},{"id":"GO:0033034","count":13},{"id":"GO:0060351","count":13},{"id":"GO:0045112","count":13},{"id":"GO:0001958","count":13}]},{"hash":"893122057999186802","title":"Insect cuticle remodeling and molting","description":"The top GO terms include chitin-based cuticle development (GO:0040003) and ecdysis (GO:0018990), which strongly indicate insect/arthropod cuticle formation and molting processes. Other related terms such as polysaccharide catabolic process and response to fungal origin support remodeling of extracellular polysaccharides and innate responses during molt. Some terms like lung or cartilage development are broader contexts and less directly tied to the\u6838\u5fc3 theme, but do not override the dominant insect cuticle/molting signal. Overall, the cluster appears to group proteins involved in chitin-containing cuticle remodeling and molting in arthropods.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":9},{"id":"GO:0071226","count":6},{"id":"GO:0071347","count":6},{"id":"GO:0000272","count":6},{"id":"GO:0040003","count":6}]},{"hash":"1194126622111147950","title":"Oxidative stress response and redox homeostasis","description":"Dominant GO terms center on oxidation\u2013reduction processes, oxidant detoxification, and redox balance, indicating a core theme of managing oxidative stress and protein quality control via ER folding. The presence of apoptosis and xenobiotic/LPS response terms suggests a broader stress-response network that can impact development in some contexts.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0098869","count":6},{"id":"GO:0006915","count":5},{"id":"GO:0045454","count":5},{"id":"GO:0032496","count":4}]},{"hash":"1998076829355119917","title":"ER organization and neutrophil signaling","description":"The Top Terms point to endoplasmic reticulum organization and ER localization, alongside neutrophil-focused functions (neutrophil mediated immunity, differentiation, and migration) and granulocyte colony-stimulating factor signaling, suggesting a cluster of proteins linked to ER-related cellular organization that interfaces with neutrophil/immune signaling, with a few outlier terms like oocyte growth and chaeta morphogenesis.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007029","count":2},{"id":"GO:0044791","count":2},{"id":"GO:0002446","count":1},{"id":"GO:0001555","count":1},{"id":"GO:0030223","count":1}]},{"hash":"501632673026717151","title":"Calcium-regulated synaptic signaling and plasticity","description":"Most terms describe calcium signaling and synaptic function: cellular response to calcium, regulation of calcium-release channels and exocytosis, and long-term potentiation. VEGF signaling can intersect calcium dynamics; a few terms are more peripheral (myelination, ABA signaling) but still compatible with neural calcium regulation. Overall, the cluster maps best to calcium-dependent synaptic signaling and plasticity.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0036324","count":2},{"id":"GO:0071277","count":2},{"id":"GO:0010881","count":2},{"id":"GO:0022011","count":2}]},{"hash":"1949959178912008811","title":"Unknown","description":"Top terms are scattered across regulation, development, and basic cellular processes, with several obsolete terms and no shared pathway or interactions (no edges/triangles). This prevents a coherent functional label, so Unknown with None confidence.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0006516","count":1},{"id":"GO:0046785","count":1},{"id":"GO:0021678","count":1}]},{"hash":"1723587404332797358","title":"Chemosensory detection and membrane transport","description":"The top GO terms show chemosensory perception (detection of chemical stimulus and olfactory behavior), implying chemosensory function. At the same time, many transmembrane transport terms across various substrates (ions, sugars, vitamins, xenobiotics) point to a broad set of transporters moving diverse molecules across membranes. Together, this cluster seems to group proteins involved in chemical sensing coupled with membrane transport. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":5},{"id":"GO:0035725","count":4},{"id":"GO:0035435","count":4},{"id":"GO:0042048","count":4},{"id":"GO:1900754","count":3}]},{"hash":"1095195744932750085","title":"Splicing Regulation and ncRNA Silencing","description":"The cluster is dominated by post-transcriptional RNA processing terms, especially spliceosome-mediated and alternative mRNA splicing, along with regulatory ncRNA\u2013mediated gene silencing. These indicate a cohesive functional theme around RNA processing and gene expression control, with a few less-connected terms (e.g., DNA replication, osteoclast development) that may reflect broader annotations. Overall, the label reflects the strongest signal in the set.","confidence":"Medium","size":25,"edges":265,"triangles":1617,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0090394","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0036010","count":2}]},{"hash":"1839170767058413213","title":"Unknown","description":"The top GO terms cover a wide range of disparate processes (ascuspores formation, DNA recombination, RNA hydrolysis, calcium signaling, angiogenesis, neuron differentiation, cytoskeletal transport, and cell proliferation) with no clear common function or pathway. Several terms are obsolete, and there are no edges connecting the proteins, making it hard to derive a cohesive label. Therefore, no specific, representative cluster name can be given.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030437","count":2},{"id":"GO:0090502","count":2},{"id":"GO:0006310","count":2},{"id":"GO:1902455","count":1},{"id":"GO:0001525","count":1}]},{"hash":"1938227520216451893","title":"Embryonic Development and Organ Morphogenesis","description":"This cluster is dominated by GO terms for embryonic development and organ morphogenesis across multiple tissues (placenta, heart, hindlimb, eye, habenula, prostate, etc.), with transcriptional regulation also highlighted, suggesting roles in developmental gene regulation and tissue patterning.","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001890","count":20},{"id":"GO:0007507","count":20},{"id":"GO:0003148","count":19},{"id":"GO:0035116","count":19},{"id":"GO:0008584","count":19}]},{"hash":"1666081292486055578","title":"Spliceosome-Driven mRNA Processing and Translation Regulation","description":"This cluster centers on spliceosome-mediated mRNA processing (splicing, cis splicing, preinitiation complex formation) and on translation initiation/reinitiation, with additional signals for mRNA stability control under stress and ncRNA-mediated gene silencing. Collectively these GO terms point to coordinated post-transcriptional regulation of mRNA maturation and translation.","confidence":"High","size":25,"edges":116,"triangles":359,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":10},{"id":"GO:0048026","count":10},{"id":"GO:0010610","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0000398","count":9}]},{"hash":"1683322121704820976","title":"Embryonic Organogenesis and Vascular Maturation","description":"This cluster is driven by organ development terms (ear, pharyngeal system, kidney) and vascular maturation (endothelin/angiotensin), with related cytokine and UV-stress responses, suggesting a theme of embryonic organogenesis coupled with vascular maturation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071493","count":3},{"id":"GO:0060037","count":3},{"id":"GO:0090399","count":2},{"id":"GO:0071492","count":2},{"id":"GO:0019233","count":2}]},{"hash":"557348765815742245","title":"Embryonic Development and Organ Morphogenesis","description":"These proteins are enriched for GO terms spanning embryonic development and tissue morphogenesis across multiple organs (eye, placenta, ovary, heart). The presence of transcription-related terms (DNA-templated transcription, transcription by RNA polymerase II) suggests that the proteins function in transcriptional regulation during development, coordinating growth, differentiation, and morphogenesis. The diversity of tissues referenced indicates a general developmental program rather than tissue-specific roles.","confidence":"Medium","size":25,"edges":242,"triangles":1265,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":14},{"id":"GO:0006351","count":12},{"id":"GO:0006366","count":12},{"id":"GO:0060528","count":11},{"id":"GO:0003148","count":11}]},{"hash":"2094893819252652444","title":"Unknown","description":"The terms are highly heterogeneous (cell cycle regulation, transcription, phosphorylation, immune and antibiotic responses, metabolism, axonogenesis), with many obsolete entries and no connecting edges, making a single cohesive function hard to establish. Therefore, I label this cluster Unknown with no confidence.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":3},{"id":"GO:0019284","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0009088","count":2}]},{"hash":"703765530974576501","title":"Neuronal signaling and actin remodeling","description":"The top GO terms point to neural signaling (neurotrophin TRK signaling, NMDA receptor clustering) and actin cytoskeleton dynamics (actin filament binding, localization to actin patches, cell polarity). Calcium signaling is also suggested by IP3 biosynthesis and calcium transport, which often coordinate signaling with cytoskeletal remodeling. Together, these terms imply a cluster of proteins involved in neuronal communication linked to actin-mediated structural changes and polarity.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036493","count":1},{"id":"GO:0036089","count":1},{"id":"GO:1904427","count":1},{"id":"GO:0006348","count":1},{"id":"GO:0048011","count":1}]},{"hash":"1107450479443801890","title":"RNA Splicing and mRNA Processing Regulation","description":"The cluster shows strong enrichment for mRNA processing and splicing control (negative and positive regulation of mRNA splicing via spliceosome, cis splicing), mRNA stability in response to stress, and related post-transcriptional regulation (translation reinitiation, regulatory ncRNA-mediated gene silencing). These together indicate a coherent theme of post-transcriptional gene expression regulation centered on RNA processing and stress response.","confidence":"High","size":25,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":17},{"id":"GO:0006378","count":17},{"id":"GO:0048025","count":16},{"id":"GO:0045292","count":16},{"id":"GO:1901407","count":15}]},{"hash":"1252119314614406742","title":"Embryonic organ morphogenesis","description":"The cluster\u2019s proteins are rich in GO terms for morphogenesis and development across multiple embryonic organs (heart, eye, hindlimb, placenta, habenula, gonads, primitive streak), indicating a shared role in embryonic tissue formation rather than a single pathway.","confidence":"High","size":25,"edges":5,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":14},{"id":"GO:0001890","count":14},{"id":"GO:2000288","count":14},{"id":"GO:0060527","count":14},{"id":"GO:0021986","count":14}]},{"hash":"922806749248705302","title":"Transcription and Translation Machinery","description":"This cluster is enriched for gene-expression processes: transcription termination/antitermination, RNA-templated transcription, and ribosome biogenesis along with translation and fidelity regulation. These terms together point to a core module of transcription-translation machinery, with some peripheral signals (antibiotic response, oxidative processes) reflecting broader cellular context.","confidence":"High","size":25,"edges":299,"triangles":2277,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0006915","count":3},{"id":"GO:0006353","count":3},{"id":"GO:0031564","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1805746150383296888","title":"Behavioral Regulation and Neural Signaling","description":"Most top GO terms relate to behavior modulation (egg-laying behavior regulation, receptivity, larval locomotion, behavioral defense) and neural signaling pathways (opioid receptor signaling, GABAergic interneuron migration, adrenergic vasodilation), suggesting the proteins cluster around neuronal control of behavior. Some terms like electron transport chain are general metabolic processes, yet energy provision often underpins behavior. Overall, the cluster seems to group proteins involved in behavioral regulation and associated neural signaling, with some peripheral terms.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045434","count":7},{"id":"GO:0048042","count":7},{"id":"GO:0002209","count":7},{"id":"GO:1901045","count":7},{"id":"GO:0008345","count":7}]},{"hash":"1413534733569410334","title":"Muscle growth and differentiation with ubiquitination","description":"This cluster\u2019s top GO terms point to muscle biology, including myoblast differentiation, muscle contraction, and growth hormone receptor signaling, suggesting roles in muscle development and function. The accompanying ubiquitination terms (protein ubiquitination and K63-linked ubiquitination) imply post-translational regulation of these signaling processes. While a few immune-related terms appear, they are less representative of the overall theme, which centers on muscle growth/differentiation and its regulation by ubiquitination.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":1},{"id":"GO:0005513","count":1},{"id":"GO:0060396","count":1},{"id":"GO:0006936","count":1},{"id":"GO:0070534","count":1}]},{"hash":"1225088053471346485","title":"Broad developmental and stress-response signaling","description":"The cluster includes terms spanning heart development, ER stress responses, autophagy, translation regulation under stress, and multiple signaling pathways (neurotrophin, insulin), plus aspects of cell division and chromatin organization, indicating a broad mix of developmental and cellular stress\u2013response processes rather than a single cohesive function. Given the diversity and lack of interaction data, the label reflects a general theme rather than a specific pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0030969","count":1},{"id":"GO:0000767","count":1},{"id":"GO:0030242","count":1},{"id":"GO:0036493","count":1}]},{"hash":"2068454053757837164","title":"Cartilage and bone ECM remodeling","description":"The top GO terms converge on extracellular matrix and skeletal development processes: collagen fibril organization and catabolic remodeling, endochondral ossification, cartilage development, and integrin-related ECM interactions. While a few terms touch on unrelated areas (podocyte development, lipid clearance, PDGF signaling), the dominant signal is ECM-mediated cartilage/bone formation and remodeling, suggesting the cluster represents proteins involved in skeletal extracellular matrix assembly and ossification pathways.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0001958","count":2}]},{"hash":"1559320858416680032","title":"Developmental signaling and morphogenesis","description":"These proteins are enriched for Hippo and Wnt signaling, apoptosis, neural tube closure, keratinocyte differentiation, and angiogenesis, all pointing to a theme of regulatory signaling governing development and tissue morphogenesis. A few terms like cellular response to lipopolysaccharide suggest broader signaling involvement, but the core enrichment centers on developmental pathway regulation and morphogenesis. ","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035329","count":22},{"id":"GO:0060044","count":22},{"id":"GO:0006915","count":22},{"id":"GO:0090263","count":22},{"id":"GO:0030216","count":22}]},{"hash":"2179270453925241120","title":"Embryonic development and organogenesis","description":"These terms point to developmental processes across tissues, including endocrine system development, placenta-related differentiation, left-right patterning, cartilage formation, and EMT in heart development. The presence of B cell development and IgG isotype switching adds an immune-development aspect, but the dominant theme is tissue differentiation and organ formation, justifying this label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048304","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2}]},{"hash":"349949027169244636","title":"Cartilage and ECM Remodeling","description":"This cluster shows GO terms tied to extracellular matrix components and skeletal development, including collagen fibril organization, collagen catabolic process, endochondral ossification, cartilage development in bone morphogenesis, and integrin biosynthetic processes. These collectively suggest a theme of ECM assembly/remodeling linked to cartilage and bone formation, with some peripheral annotations. Confidence: Medium","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":1},{"id":"GO:0033034","count":1},{"id":"GO:0060351","count":1},{"id":"GO:0045112","count":1},{"id":"GO:0001958","count":1}]},{"hash":"1569517083774149521","title":"Unknown","description":"The top GO terms are a mix of enterobacterial common antigen biosynthesis, collagen biosynthesis/organization and cell adhesion, complement activation, and metal ion detoxification/homeostasis. This broad and disparate set suggests no single cohesive function tying the proteins together, and the absence of edges/triangles supports an Unknown cluster.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":3},{"id":"GO:0030199","count":2},{"id":"GO:0032964","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0006958","count":2}]},{"hash":"1092878906627797465","title":"Immune Signaling and Tissue Morphogenesis","description":"The terms mix immune signaling (cellular response to fungal origin, C-type lectin receptor signaling, basophil and platelet activation) with tissue development processes (cartilage condensation, metanephric tubule morphogenesis, lymph vessel morphogenesis). This suggests proteins involved in signaling that interfaces with developmental morphogenesis across tissues, rather than a single cohesive pathway, justifying a combined label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":10},{"id":"GO:0001502","count":10},{"id":"GO:0010572","count":10},{"id":"GO:0045575","count":9},{"id":"GO:0072237","count":9}]},{"hash":"1185107939824099325","title":"Multisystem Development and Vascular Regulation","description":"The top GO terms cluster around development across multiple organs (retina/eye and heart) and processes tied to vascular function (vascular permeability, blood coagulation, urine volume regulation), with supporting themes of transcription and cell proliferation. This suggests a broad developmental program impacting several tissues with an emphasis on vascular-related regulation rather than a single, specific pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045494","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0019835","count":2},{"id":"GO:0008284","count":2}]},{"hash":"2195923923982080154","title":"Meiosis and oocyte maturation with ubiquitin-proteasome regulation","description":"The top terms cluster around SCF-dependent ubiquitin-proteasomal degradation, spindle assembly in meiosis, oocyte maturation, and microtubule polymerization, indicating a cohesive role in meiotic progression and cytoskeletal dynamics regulated by the ubiquitin-proteasome system. While a few neural-development terms appear, the dominant signal reflects proteostasis and meiotic/oocyte development processes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":14},{"id":"GO:0006516","count":13},{"id":"GO:0046785","count":13},{"id":"GO:0021678","count":13},{"id":"GO:0021993","count":13}]},{"hash":"1786415921634682226","title":"Membrane Transporters (Ions & Small Molecules)","description":"The GO terms are dominated by diverse transmembrane transport activities for ions and small molecules (sodium, potassium, nitrate/nitrite, phosphate, sialic acid, xenobiotics) and include a neurotransmitter loading term, suggesting a cluster of membrane transporter proteins with varied substrates and a shared transport function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0015706","count":4},{"id":"GO:0006855","count":4}]},{"hash":"1460804779564209340","title":"Peroxisomal fatty acid oxidation and growth signaling","description":"The frequent GO terms point to lipid metabolism, notably carnitine metabolic process and beta-oxidation via acyl-CoA oxidase, indicating peroxisomal fatty acid oxidation. Additional terms about heart development and cellular responses to IGF and TGF-beta stimuli suggest links to energy metabolism in cardiac development and growth signaling. Other terms (actin capping, GTPase regulation) are broader, but the lipid-oxidation theme is the strongest unifying thread.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019254","count":3},{"id":"GO:0033540","count":3},{"id":"GO:0009409","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0055114","count":3}]},{"hash":"931088570156545789","title":"Unknown","description":"The Top Terms are a mix of unrelated processes (DNA-templated transcription; visual perception; pancreatic juice secretion; kidney tubule development; lipid digestion; salt stress response; cGMP biosynthesis; intracellular water homeostasis), with no clear unifying theme across the cluster and no edges to suggest a shared pathway. There is even an obsolete GO term among the set. This lack of a cohesive functional signal means a meaningful, specific label cannot be assigned. ","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0018401","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0044241","count":1},{"id":"GO:0009992","count":1}]},{"hash":"1980829569177370874","title":"Unknown","description":"The top terms span diverse biological areas, including EGFR ligand maturation, developmental fate specification (wing and cone cells), spermatid differentiation, immune regulation (NK cell activation), and stress/protein quality control (unfolded protein response and ER-to-cytosol proteolysis). The absence of edges/structured relationships and the lack of a single dominant function across all 25 proteins suggest no cohesive theme to label. Therefore, Unknown with None confidence.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038005","count":3},{"id":"GO:0032815","count":3},{"id":"GO:0035311","count":3},{"id":"GO:0048515","count":3},{"id":"GO:0034620","count":3}]},{"hash":"1816655715947628233","title":"Cartilage and bone ECM remodeling","description":"The cluster is dominated by terms linked to cartilage development, endochondral ossification, and collagen fibril organization/catabolism, plus integrin biosynthesis, pointing to extracellular matrix remodeling during skeletal development. Immune terms are present but secondary to the ECM/bone morphogenesis theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045650","count":4},{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3},{"id":"GO:0045112","count":3}]},{"hash":"211017064535027105","title":"Insect egg-laying regulation via GPCR signaling","description":"The top GO terms heavily emphasize regulation and negative regulation of egg-laying behavior and female receptivity, pointing to a cluster involved in modulating reproductive behavior. Several terms also indicate GPCR- and adenylate cyclase\u2013mediated signaling, which commonly underlie neuroendocrine control of reproduction. Additional terms cover larval locomotion and behavioral defense, suggesting a broader behavioral/neuronal context, but the dominant theme remains GPCR-driven regulation of reproductive behavior in insects.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048042","count":10},{"id":"GO:0045434","count":10},{"id":"GO:0008345","count":10},{"id":"GO:0002209","count":10},{"id":"GO:1901045","count":10}]},{"hash":"2066719740601110900","title":"Neuronal synaptic plasticity and receptor clustering","description":"The terms coalesce around neuronal synaptic function: long-term plasticity and its regulation, clustering of NMDA and AMPA glutamate receptors, calcium signaling, and GABA secretion, all central to synaptic transmission and plasticity. The presence of fear-regulation suggests involvement in fear learning circuits (e.g., amygdala). While manganese transport is a minor ion-handling term, the core theme is synaptic plasticity and receptor organization in neurons.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":3},{"id":"GO:0006828","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0014051","count":2},{"id":"GO:0098703","count":2}]},{"hash":"687135427494947098","title":"RNA processing and translation initiation","description":"The cluster\u2019s top GO terms center on RNA maturation and post-transcriptional regulation (splicing, splice-site recognition, export, stability during stress, polyadenylation) as well as translation initiation and reinitiation (formation of the translation preinitiation complex, translation reinitiation). This points to a cohesive set of proteins involved in RNA processing and control of translation, with some terms reflecting related regulatory activities. Therefore, a label emphasizing RNA processing and translation initiation best represents the shared function of the proteins.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":8},{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0031047","count":7},{"id":"GO:0006376","count":7}]},{"hash":"1528841745789640201","title":"Unknown","description":"The GO terms cover DNA replication, RNA splicing, neuron signaling, tracheal development, neuron remodeling, and various membrane transports (ammonium, lysine, ornithine). This mix lacks a single cohesive function, suggesting a heterogeneous cluster or annotation noise, so there is no clear theme to name it.","confidence":"","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0000387","count":1},{"id":"GO:0007270","count":1},{"id":"GO:0007430","count":1},{"id":"GO:0035155","count":1}]},{"hash":"284670165765561613","title":"Mammalian Developmental Signaling and Angiogenesis","description":"The top GO terms cluster around developmental processes and tissue morphogenesis (placenta development, skeletal muscle development, angiogenesis, heart looping regulation) and hormonal/apoptotic signaling (response to estrogen, apoptotic process), suggesting a group of proteins involved in developmental regulation and tissue formation, with some metabolic/ion transport functions as supporting activities. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0043627","count":2}]},{"hash":"15091276949514761","title":"Developmental differentiation and cell cycle regulation","description":"GO terms show a pattern of tissue development and differentiation (lung epithelium, face morphogenesis, retinal bipolar neurons) coupled with cell cycle and cytokinesis control (mitotic cell cycle, proliferation). Added signaling elements (GTPase regulation, calcium sensing) reinforce a theme of development linked to cell division and signaling. Confidence: High","confidence":"","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060487","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0032465","count":6},{"id":"GO:0097274","count":6},{"id":"GO:0000278","count":6}]},{"hash":"452684160392400649","title":"Gram-positive cell wall biosynthesis and antibiotic response","description":"The GO terms cluster around lipoteichoic acid biosynthesis, cell wall organization, regulation of cell shape, and antibiotic-related processes, suggesting a cohesive theme of Gram-positive cell envelope biosynthesis and interactions with antibiotics; a few plant-associated biosynthetic terms appear as outliers but do not dominate the signal.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070395","count":6},{"id":"GO:0071555","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0005975","count":5},{"id":"GO:0009718","count":5}]},{"hash":"933745850579150066","title":"Rhodopsin-Mediated Photoreceptor Signaling and Membrane Transport","description":"The top GO terms are centered on photoreceptor signaling and sensory perception (notably rhodopsin-mediated membrane potential maintenance and detection of chemical stimuli), with accompanying transport and energy-related processes (nucleotide transport, proton transmembrane transport, and mitochondrial respiration) that support signaling. This suggests a cohesive theme around photoreceptor sensory signaling with membrane transport. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016058","count":1},{"id":"GO:0015862","count":1},{"id":"GO:0035364","count":1},{"id":"GO:0050907","count":1},{"id":"GO:0034551","count":1}]},{"hash":"358833198276095839","title":"ER trafficking and calcium homeostasis","description":"The set is enriched for GO terms pointing to endoplasmic reticulum (protein localization to ER, COPII-coated vesicle budding), ER-associated processes (unfolded protein response), and calcium ion homeostasis, suggesting a cluster centered on ER trafficking and calcium regulation. Some terms also touch on development and transcription regulation, which may reflect broader roles in differentiation, but the core shared function appears to be ER secretory pathway activity and its regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0045598","count":2},{"id":"GO:0090114","count":1},{"id":"GO:0006987","count":1}]},{"hash":"975981885658942440","title":"Mitochondrial Respiratory Chain and ATP Synthesis","description":"The cluster is dominated by GO terms for mitochondrial electron transport and ATP synthesis (NADH to ubiquinone; cytochrome c to oxygen; proton transmembrane transport; and ATP synthesis coupled to electron transport), indicating a cohesive energy metabolism theme; a few ER chaperone/refolding and ubiquitin-dependent ERAD terms appear as less representative annotations, but do not override the primary mitochondrial respiration signal.","confidence":"High","size":24,"edges":120,"triangles":270,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":3},{"id":"GO:0034975","count":2},{"id":"GO:0070389","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1462508518145341493","title":"Unknown","description":"The top GO terms are highly diverse (energy metabolism, signaling, viral and bacterial interactions, behavioral terms) with no clear unifying function among the proteins, and there are no network edges to anchor a cohesive theme. This makes a specific, representative label unlikely.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":2},{"id":"GO:0007194","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0051482","count":2},{"id":"GO:0007626","count":2}]},{"hash":"351284963886273359","title":"Unknown","description":"Top terms are scattered across sensory perception, development, immunity, and signaling with no common biological theme. The lack of edges (Edges: 0; Triangles: 0) indicates no cohesive functional connectivity among the proteins, supporting an Unknown function label.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0006221","count":2},{"id":"GO:0072233","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0002455","count":1}]},{"hash":"362146380653678730","title":"Actin Cytoskeleton Remodeling and Rho Signaling","description":"This cluster is dominated by GO terms related to actin cytoskeleton dynamics (actin crosslink formation; cytoskeleton reorganization) and regulation of Rho signaling, with a notable inclusion of karyogamy/conjugation-related fusion\u2014processes that rely on cytoskeletal remodeling. Other terms present (detoxification, endocannabinoid signaling, lipid catabolism) appear less central, but the cytoskeletal theme is the strongest link.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":5},{"id":"GO:0098869","count":4},{"id":"GO:2000124","count":4},{"id":"GO:0019433","count":4},{"id":"GO:0070493","count":3}]},{"hash":"1375831368982798550","title":"IGF/EGF Growth Signaling in Development","description":"The cluster centers on insulin-like growth factor receptor signaling and epidermal growth factor\u2013stimulated responses, with downstream PI3K signaling and regulation of glycogen biosynthesis, and includes terms related to cardiac and spinal cord development as well as TGF-\u03b21 regulation. This suggests a cohesive theme of growth factor\u2013driven signaling guiding developmental processes, despite some obscure/obsolete or non-specific terms. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":3},{"id":"GO:0048009","count":2},{"id":"GO:0014065","count":2},{"id":"GO:0045725","count":2},{"id":"GO:0071364","count":2}]},{"hash":"2061094425875590566","title":"Stress-Responsive Kinase Signaling and Cell Cycle Control","description":"This cluster centers on regulation of kinase activity (autophosphorylation and serine/threonine kinase activity), signaling responses to stress (hypoxia and cadmium ion), and links to cell cycle control (mitotic cycle, G1/S transcription) with proteostasis (SCF-dependent degradation) and mRNA transport, suggesting a cohesive theme of signaling-driven regulation during stress and division.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031954","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0071902","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007205","count":2}]},{"hash":"1166126965530986562","title":"Oocyte meiosis: spindle assembly and maturation","description":"The top GO terms emphasize spindle assembly in female meiosis I, oocyte maturation, and microtubule polymerization, along with SCF-dependent proteasomal protein catabolic processes. This combination points to meiotic progression and spindle dynamics in oocytes as the core theme of the cluster, with some broader developmental terms as ancillary context. Confidence in the label being representative is High.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070544","count":19},{"id":"GO:0031146","count":19},{"id":"GO:0007057","count":19},{"id":"GO:0021993","count":19},{"id":"GO:0008285","count":19}]},{"hash":"2267361884810601101","title":"Unknown","description":"The GO terms cover both kidney development processes (metanephric proximal/distal tubule morphogenesis, metanephric ascending limb development) and diverse immune signaling pathways (basophil activation, C-type lectin receptor signaling, NK cell chemotaxis, response to fungal origin) with no single dominant theme linking all proteins. Because there is no cohesive functional theme across the cluster, the label Unknown is most appropriate, with no confidence in a representative function.","confidence":"","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0045575","count":16},{"id":"GO:0072237","count":16},{"id":"GO:0036303","count":16},{"id":"GO:0072287","count":16},{"id":"GO:0002223","count":16}]},{"hash":"1797331394933565045","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0061158","count":4},{"id":"GO:0046782","count":4},{"id":"GO:0002181","count":4}]},{"hash":"584613000819885221","title":"Unknown","description":"The set includes apoptotic and cell-cycle related terms (apoptotic process, spindle assembly, exit from mitosis), alongside signaling (Wnt), telomere maintenance, mRNA processing, and vesicular transport. These reflect multiple, diverse cellular processes with no single cohesive function standing out, so a specific, concise label isn\u2019t supported.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0050907","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0051225","count":2}]},{"hash":"1365001806942181884","title":"Neuromuscular development and movement","description":"The GO terms center on neuromuscular biology: spinal cord motor neuron differentiation, neuromuscular process controlling balance, and musculoskeletal movement, plus IGF receptor signaling linked to muscle growth. While there are additional terms about cell cycle and transcriptional/post-transcriptional regulation, the neuromuscular theme is the strongest through-line.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0048873","count":2},{"id":"GO:0061157","count":2},{"id":"GO:0050881","count":2},{"id":"GO:0031571","count":2}]},{"hash":"2168160991961990762","title":"Unknown","description":"The GO terms are very diverse (immune signaling, heart development, ER stress\u2013related translation, calcium transport, chromatin organization, neurotrophin signaling, actin dynamics, IP3 biosynthesis), and there is no clear single function tying the proteins together, plus there are no edges or interactions suggesting a common pathway. Therefore no coherent label can be confidently assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0036493","count":2},{"id":"GO:1904427","count":2},{"id":"GO:0006348","count":2}]},{"hash":"569037747235014010","title":"Oocyte maturation and meiotic spindle assembly","description":"The terms are dominated by oocyte maturation, spindle assembly in female meiosis I, and microtubule polymerization, along with SCF-dependent proteasomal degradation, pointing to meiosis-specific spindle dynamics and proteostasis; a few neural tube/development terms seem incidental. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":9},{"id":"GO:0046785","count":9},{"id":"GO:0021678","count":9},{"id":"GO:0021993","count":9},{"id":"GO:0070544","count":9}]},{"hash":"1316884606926356736","title":"B cell signaling and germinal center formation","description":"The cluster includes immune-related terms such as B cell receptor signaling pathway and germinal center formation, suggesting an immune signaling theme. Other terms (muscle, placenta, phototropism, transcription) are less coherent with this core, indicating some annotation noise; thus the label emphasizes B cell\u2013associated processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0001890","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0009638","count":3}]},{"hash":"1766392021720639398","title":"Nematode cuticle formation and molting","description":"The top GO terms are dominated by molting cycle and collagen/cuticle-related processes, indicating a core function in nematode cuticle synthesis and shedding. Other terms appear peripheral (pharyngeal pumping, Notch signaling), but do not override the main theme. This supports a specific label around nematode cuticle formation and molting.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":5},{"id":"GO:0043050","count":5},{"id":"GO:0045444","count":2},{"id":"GO:0043248","count":1},{"id":"GO:0010950","count":1}]},{"hash":"855484804080267969","title":"Glycosylation and Ciliary Signaling Components","description":"Top terms point to glycosylation and membrane-associated biosynthesis (enterobacterial common antigen biosynthesis, GPI anchor biosynthesis, dolichol-linked oligosaccharide biosynthetic process) and to ciliogenesis/signaling (non-motile cilium assembly, Smoothened signaling pathway). Although some terms are peripheral (pollen tube guidance, reproductive behavior), the shared theme connects glycan/membrane biosynthesis with ciliary signaling pathways. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":3},{"id":"GO:0006506","count":1},{"id":"GO:0006488","count":1},{"id":"GO:0010183","count":1},{"id":"GO:0007224","count":1}]},{"hash":"706524126950922116","title":"Cytoskeletal organization and membrane trafficking","description":"Top GO terms reveal a cohesive theme around cytoskeletal dynamics and membrane trafficking, including plus-end directed microtubule sliding, actin cortical patch assembly, and regulation of endocytosis, as well as zonula adherens maintenance. Stress granule disassembly also ties into RNA-protein granule dynamics linked to the cytoskeleton. Developmental terms for muscle and brain may reflect tissue-specific roles or annotation biases, but the dominant signal points to a module coordinating cytoskeleton remodeling, cell cortex organization, and membrane trafficking. Confidence: Medium","confidence":"","size":23,"edges":116,"triangles":152,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":7},{"id":"GO:0032508","count":5},{"id":"GO:0030100","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0021762","count":5}]},{"hash":"976261514884795102","title":"Ubiquitin-Dependent Protein Turnover","description":"The cluster is centered on ubiquitination processes, notably K48- and K63-linked ubiquitination and ubiquitin-dependent protein catabolic processes, which points to a core function in ubiquitin signaling and protein degradation. The other terms (e.g., blastocyst formation, lymph node development, host-mediated suppression of symbiont invasion) likely reflect broader, context-specific roles of ubiquitin-related proteins rather than a single dominant function of the cluster. Overall, ubiquitin-mediated turnover best captures the shared theme among the top terms.","confidence":"Medium","size":23,"edges":18,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0070534","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0051026","count":2},{"id":"GO:0070936","count":2},{"id":"GO:0001825","count":2}]},{"hash":"342413634795632056","title":"Unknown","description":"The terms include kidney development (metanephric tubule morphogenesis) and diverse immune pathways (basophil activation, C-type lectin receptor signaling, response to fungal origin), with no single cohesive function tying all proteins together; this makes a specific, representative label unlikely.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":3},{"id":"GO:0072237","count":3},{"id":"GO:0036303","count":3},{"id":"GO:0072287","count":3},{"id":"GO:0002223","count":3}]},{"hash":"424962439149021547","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":51,"triangles":25,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0000398","count":6},{"id":"GO:1901407","count":6},{"id":"GO:0034475","count":5}]},{"hash":"1677913331615236378","title":"Nuclear RNA Processing and Ribosome Biogenesis","description":"The cluster is dominated by GO terms tied to nuclear RNA processing and ribosome assembly, including mRNA splicing via spliceosome, spliceosomal snRNP assembly, ribosome biogenesis, maturation of SSU-rRNA, and import into nucleus. These reflect a coherent theme of RNA processing and ribosome production within the nucleus. A couple of terms (SOS response, lipopolysaccharide biosynthetic process) appear as outliers, which may reflect cross-species annotations or broader regulatory connections, but do not override the core theme.","confidence":"Medium","size":23,"edges":40,"triangles":0,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0000387","count":3},{"id":"GO:0000027","count":3},{"id":"GO:0009432","count":3},{"id":"GO:0006260","count":3}]},{"hash":"1276585799064589512","title":"Diverse regulatory processes","description":"The GO terms show a broad mix of regulatory functions (e.g., transcriptional regulation, signaling pathway regulation, ubiquitination, immune regulation, and neuronal transport) rather than a single cohesive pathway. This indicates the cluster comprises proteins involved in multiple, diverse regulatory roles, making a specific, tight label unlikely. ","confidence":"Low","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0006400","count":1},{"id":"GO:0018339","count":1},{"id":"GO:0070534","count":1},{"id":"GO:0031664","count":1}]},{"hash":"307959443829142224","title":"Nuclear import/export and pore complex assembly","description":"This cluster centers on nuclear trafficking: NLS-bearing protein import, mRNA export, ribosomal protein import, and nuclear pore complex assembly, indicating a cohesive group of proteins involved in nuclear transport and pore formation. Related terms such as intraciliary transport and regulation of protein turnover appear as supportive but secondary connections to transport and protein regulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0006406","count":5},{"id":"GO:0035735","count":5},{"id":"GO:0000060","count":5}]},{"hash":"1493973632677768241","title":"Vacuolar amino acid transport","description":"The top GO terms are dominated by transmembrane transport into and out of the vacuole for multiple amino acids (e.g., L-arginine, L-serine, L-tyrosine, L-lysine, L-proline, L-asparagine, etc.), indicating a cohesive set of vacuolar amino acid transport proteins. Some obsolete terms appear as noise, but the recurring theme is AA movement across the vacuolar membrane, suggesting a transport-focused cluster rather than a single enzymatic function.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":2},{"id":"GO:0061402","count":1},{"id":"GO:1901482","count":1},{"id":"GO:0090516","count":1},{"id":"GO:0006867","count":1}]},{"hash":"1860212217975268030","title":"Developmental transcription and circadian regulation","description":"This cluster centers on transcriptional control (RNA polymerase II) and circadian regulation of gene expression, with strong developmental signals across tissues\u2014embryonic eye morphogenesis and in utero development, skeletal muscle differentiation, habenula and lung vasculature development\u2014suggesting a theme of transcription-driven developmental programs with temporal regulation.","confidence":"High","size":23,"edges":129,"triangles":125,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0032922","count":6},{"id":"GO:0043433","count":6},{"id":"GO:0048048","count":6},{"id":"GO:0001701","count":6}]},{"hash":"1025656326890968270","title":"Developmental Transcription Regulation","description":"The cluster centers on DNA-templated transcription, with multiple terms for transcriptional regulation and several development-related processes (neural tube development, fat cell differentiation). Though some terms are obsolete and others touch on proliferation and microtubule dynamics, the dominant theme is transcriptional control in development.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0043433","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2}]},{"hash":"1711157092392730180","title":"ERK and p38 MAPK immune/stress signaling","description":"This cluster is driven by GO terms for ERK1/ERK2 cascade and p38MAPK cascade, plus cellular responses to LPS, GM-CSF stimulus, and phorbol ester, indicating MAPK-mediated signaling in immune and stress contexts. Additional terms like trans-synaptic and osmosensory signaling support broad signaling roles, though a couple of outliers (telomere maintenance, axial mesoderm formation) exist. Overall, the MAPK signaling theme is dominant, so the label reflects the core function. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:0070371","count":2},{"id":"GO:1904628","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0038066","count":2}]},{"hash":"1164065127982754821","title":"Developmental Signaling and Immune Response","description":"This cluster centers on transcriptional regulation (DNA-templated transcription) and signaling (p38MAPK cascade) with several developmental themes (heart, face, placenta development, fat cell differentiation). The presence of cellular response to lipopolysaccharide links to immune/stress signaling, which often engages MAPK pathways and transcriptional control, suggesting an integrated developmental\u2013immune signaling program rather than a single discrete process.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":15},{"id":"GO:0071222","count":12},{"id":"GO:2001275","count":11},{"id":"GO:0043433","count":11},{"id":"GO:0038066","count":11}]},{"hash":"584498329722973631","title":"Developmental Morphogenesis and Gene Regulation","description":"The top GO terms point to developmental processes across multiple tissues (retina development, brain segmentation, osteoblast development, angiogenesis) and regulatory roles in gene expression (signal transduction related to gene regulation and transcriptional control). While there are also stressresponse terms, the prevailing theme is development and regulation of growth/morphogenesis.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0002076","count":3},{"id":"GO:0035284","count":3},{"id":"GO:0000122","count":3}]},{"hash":"2038449223842038151","title":"B cell signaling and actin remodeling","description":"The cluster is enriched for B cell receptor signaling, B cell differentiation/homeostasis, and actin cytoskeleton dynamics (actin cytoskeleton reorganization and actin filament binding), with PKC activation also represented. Together these suggest a theme of B cell activation coupled with cytoskeletal remodeling during signaling. Some hematopoietic terms like megakaryocyte development and angiogenesis appear less dominant but indicate broader hematopoietic context.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000251","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0045931","count":2},{"id":"GO:1990051","count":2}]},{"hash":"1262409364875051","title":"Wnt/BMP signaling regulation and neural development","description":"The enrichment centers on regulators of Wnt and BMP signaling during development, plus processes linking these pathways to limb morphogenesis, heart induction, and neural synapse formation. The combination of signaling pathway regulation and neural connectivity terms suggests a coherent theme of developmental signaling control with neural differentiation/synapse regulation.","confidence":"Medium","size":23,"edges":16,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098883","count":1},{"id":"GO:0090082","count":1},{"id":"GO:0030326","count":1},{"id":"GO:1904723","count":1},{"id":"GO:0030514","count":1}]},{"hash":"879568355403608787","title":"CNS neural development and visual system maintenance","description":"This cluster is dominated by terms tied to central nervous system development and sensory/visual system processes, including hippocampus development, myelination, dendrite morphogenesis, photoreceptor cell maintenance, and visual perception, plus CNS projection neuron axonogenesis. The presence of cilium assembly regulation and hedgehog pathway signaling hints at broader neural differentiation and sensory cell maturation roles, all pointing to CNS/visual system\u2013related functions rather than unrelated pathways. Overall, the proteins appear to participate in neural development with a focus on the visual system.","confidence":"Medium","size":23,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021766","count":2},{"id":"GO:0042552","count":2},{"id":"GO:1902857","count":1},{"id":"GO:0007601","count":1},{"id":"GO:1900181","count":1}]},{"hash":"1369748235544393857","title":"Diverse metabolite biosynthesis","description":"The GO terms are all biosynthetic processes for a variety of compounds (antibiotics, anthocyanins, PHB, retinol, fatty acids, phylloquinone, testosterone, etc.), pointing to a broad theme of metabolite biosynthesis rather than a single pathway. The lack of network connectivity (edges/triangles) suggests these proteins may participate in multiple, distinct biosynthetic routes, but the overarching link is biosynthesis of diverse metabolites.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":9},{"id":"GO:0055114","count":9},{"id":"GO:0009718","count":7},{"id":"GO:0042619","count":6},{"id":"GO:0042572","count":6}]},{"hash":"1966137089192805402","title":"Transcription Regulation and Differentiation","description":"This cluster centers on transcriptional control, with terms for RNA polymerase II preinitiation complex assembly and DNA-templated transcription initiation, plus multiple differentiation-related terms (intestinal epithelial cell differentiation, granulocyte differentiation, stem cell proliferation) and Notch signaling regulation. The mix of transcriptional regulation and developmental/differentiation processes suggests proteins involved in controlling gene expression to drive cell fate decisions, rather than a single pathway. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051123","count":2},{"id":"GO:0006352","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0045820","count":1},{"id":"GO:1903715","count":1}]},{"hash":"2142796961523321998","title":"Unknown","description":"Top terms point to multiple, disparate processes: developmental signaling (Wnt signaling, ephrin signaling, skin morphogenesis, synaptic plasticity regulation), telomere/chromosome localization and maintenance, and ADP-ribosylation. Because these functions do not converge on a single mechanism, there is no clear shared function to name the cluster confidently.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":2},{"id":"GO:0043589","count":2},{"id":"GO:0070198","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0070213","count":2}]},{"hash":"1866963694798053021","title":"Neural development and calcium signaling","description":"The cluster centers on neural differentiation and signaling, with terms like retinal bipolar neuron differentiation, axonogenesis, and neurotransmitter secretion, plus calcium-related processes (detection of calcium ion and calcium-release channel activity). While a few terms pertain to broader development or endocrine contexts (face morphogenesis, thyroid hormone metabolism, mammary involution), the neural development and calcium signaling terms are the most prominent, suggesting a cohesive functional theme around neural development and calcium-mediated signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042403","count":4},{"id":"GO:0060056","count":4},{"id":"GO:0060325","count":3},{"id":"GO:0005513","count":3},{"id":"GO:0060316","count":3}]},{"hash":"918449092745730953","title":"Ubiquitin-Dependent Proteolysis and NF-kB Signaling","description":"Proteins cluster around the ubiquitin-proteasome system: SCF-dependent proteasomal degradation, ERAD, and ubiquitin-dependent catabolic processes, with multiple ubiquitin linkage types (K48, K63, K11, K6) and autoubiquitination. The inclusion of terms related to positive regulation of canonical NF-kB signaling indicates a link between ubiquitination events and NF-kB pathway activation, suggesting these proteins function together in ubiquitin-mediated proteolysis and NF-kB signaling modulation.","confidence":"High","size":23,"edges":5,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":12},{"id":"GO:0042787","count":11},{"id":"GO:0030433","count":8},{"id":"GO:0070534","count":6},{"id":"GO:0051865","count":6}]},{"hash":"37974224229781471","title":"ER stress and COPII vesicle trafficking","description":"The top GO terms cluster around endoplasmic reticulum (ER) processes: COPII-coated vesicle budding, protein localization to the ER, ER unfolded protein response, calcium ion homeostasis in the ER, and exocytosis, all pointing to ER-to-Golgi transport and ER stress signaling as the core theme. There are some host-virus interaction terms, which may reflect cellular responses during viral infection, but the dominant pattern is ER handling and secretory pathway trafficking.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":3},{"id":"GO:0006987","count":3},{"id":"GO:0044828","count":3},{"id":"GO:0006874","count":3},{"id":"GO:0044829","count":3}]},{"hash":"396496906954096061","title":"Unknown","description":"The top GO terms are highly diverse, spanning energy metabolism, mitochondrial complex assembly, membrane transport, sensory perception, vascular functions (angiogenesis, smooth muscle proliferation, blood-brain barrier maintenance) and inflammatory signaling (TNF response, NF-kappaB). There is no clear, cohesive functional theme tying the cluster together, and there are no edges linking proteins, suggesting the cluster cannot be assigned a specific, interpretable label.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042774","count":1},{"id":"GO:0033617","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0007606","count":1},{"id":"GO:0001525","count":1}]},{"hash":"2096477017113797811","title":"Signaling-driven Cytoskeletal Dynamics","description":"Top GO terms center on canonical Wnt signaling, GTPase activation, regulation of Rho signaling, and actin cytoskeleton organization, pointing to a theme of signaling pathways that coordinate cytoskeletal remodeling. The presence of DNA-templated transcription and other regulatory terms suggests downstream transcriptional control as part of these signaling processes. Some tissue- or process-specific terms may reflect broader regulatory roles or noise, but overall the cluster seems to reflect signaling-driven cytoskeletal regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":2},{"id":"GO:0060070","count":2},{"id":"GO:1902953","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0033601","count":2}]},{"hash":"1084961751434423154","title":"Ubiquitin-Proteasome Proteolysis and Developmental Processes","description":"The top GO terms are dominated by ubiquitin-dependent proteolysis and SCF-dependent proteasomal pathways, indicating proteasome-mediated protein degradation. Additional terms include glycoprotein catabolic process and microtubule polymerization, suggesting coordination between protein turnover and cytoskeletal dynamics tied to the cell cycle. Developmental terms such as third ventricle development, initiation of neural tube closure, and oocyte maturation imply involvement in developmental regulation that can be controlled by proteolysis. Overall, the cluster appears centered on ubiquitin-proteasome\u2013driven proteolysis with links to cell division and development.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0031146","count":9},{"id":"GO:0006516","count":8},{"id":"GO:0046785","count":8},{"id":"GO:0021678","count":8}]},{"hash":"371829289295007047","title":"RNA Processing and Transcription Regulation","description":"Dominant GO terms are mRNA processing, rRNA processing, and DNA-templated transcription, indicating a core function in gene expression regulation at transcriptional and post-transcriptional steps. Some peripheral terms (actin filament assembly, T cell cytokine regulation, glucose response) suggest a broader functional mix rather than a single, cohesive pathway.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0008285","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0002724","count":2},{"id":"GO:0071333","count":2}]},{"hash":"2198347395880680294","title":"Innate immune defense against pathogens","description":"Most GO terms point to innate immunity and pathogen response (innate immune response, defense response to Gram-positive bacterium, cellular response to LPS, cellular response to molecule of fungal origin, response to antibiotic), suggesting the cluster centers on antimicrobial defense. A few terms are divergent (axonogenesis, abscisic acid signaling, cyclic nucleotide biosynthetic process, apoptotic regulation), which lowers confidence slightly but does not override the overall theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007409","count":3},{"id":"GO:0009190","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0014068","count":2}]},{"hash":"564372639591528111","title":"Growth Factor Signaling and Cytoskeleton Regulation","description":"The cluster centers on signaling through growth factor receptors (growth hormone receptor, insulin/IGF receptor pathways) and links this signaling to cytoskeleton remodeling and cell motility (actin organization, focal adhesion regulation, and migration processes). This points to a cohesive theme where growth factor signaling modulates adhesion and movement, including developmental morphogenesis contexts such as imaginal disc leg formation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060396","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0021816","count":1},{"id":"GO:0046626","count":1},{"id":"GO:0090038","count":1}]},{"hash":"1065177553656325763","title":"Ubiquitin-Proteasome Stress Response","description":"The top terms point to ubiquitin-dependent protein degradation (K11-linked ubiquitination and ubiquitin-dependent catabolic process) and response to unfolded protein, indicating a proteostasis and stress-response cluster. Phosphorylation suggests signaling roles as well. Some terms (e.g., heart development, amino acid biosynthesis) may reflect annotation noise, but the dominant theme is ubiquitin\u2011mediated quality control under stress.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0019284","count":3},{"id":"GO:0016310","count":3},{"id":"GO:0019509","count":3},{"id":"GO:0009088","count":3}]},{"hash":"1517117082028420594","title":"Ion Transport and Redox Signaling","description":"The cluster is enriched for ion transmembrane transport terms (potassium and sodium) along with redox homeostasis and several signaling-related terms (IGF receptor signaling, PKC activity, and respiratory burst regulation). This points to a set of proteins involved in membrane transport tied to cellular signaling and oxidative stress responses, rather than a single cohesive pathway. The presence of a developmental term (genital disc primordium) likely reflects annotation overlap or noise. Overall, the dominant theme is ion transport with linked signaling and redox regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0035225","count":1}]},{"hash":"939564199692283466","title":"Magnesium Ion Homeostasis and Transport","description":"The top GO terms show a clear emphasis on magnesium ion biology, including intracellular magnesium ion homeostasis, cellular response to magnesium ion, and magnesium ion transmembrane transport, which together point to a magnesium-centric functional theme for the cluster. A few other terms appear but are singletons and do not cohere into a stronger alternative function. Therefore, labeling this cluster as Magnesium Ion Homeostasis and Transport is appropriate, though the signal is modest given the limited number of magnesium-related terms among 23 proteins.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":2},{"id":"GO:0010961","count":1},{"id":"GO:0071286","count":1},{"id":"GO:1903830","count":1},{"id":"GO:0009246","count":1}]},{"hash":"585204837052740508","title":"Ribosome biogenesis and rRNA processing","description":"The explicit rRNA maturation terms (LSU and 5.8S rRNA processing) point to ribosome biogenesis, i.e., maturation of ribosomal RNA. Other terms touch on nuclear transcription regulation and chromatin-related modifications, which may reflect broader nuclear context, but the strongest and most coherent signal across the cluster is ribosome assembly-related processing.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0097421","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000122","count":2}]},{"hash":"417277826816722635","title":"Transmembrane Transporters for Ions and Metabolites","description":"Based on the predominance of transmembrane transport terms across a range of ions (Na+, K+, nitrate, nitrite, phosphate) and small molecules (sialic acid, xenobiotics, 4-hydroxyphenylacetate) plus a role in neurotransmitter loading into vesicles, the cluster appears to group membrane transporter proteins handling ions and metabolites. This makes a specific, compact label capturing the shared function appropriate.","confidence":"High","size":22,"edges":32,"triangles":11,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":7},{"id":"GO:0035461","count":7},{"id":"GO:0035725","count":7},{"id":"GO:0015706","count":7},{"id":"GO:0006855","count":7}]},{"hash":"737386314760526275","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":98,"triangles":149,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0016973","count":5},{"id":"GO:0034475","count":5},{"id":"GO:0006369","count":5},{"id":"GO:0071042","count":5},{"id":"GO:0034476","count":5}]},{"hash":"1431262826559327135","title":"Mitochondrial Transport and Membrane Dynamics","description":"The proteins are enriched for GO terms related to mitochondrial metabolite transport (ATP, citrate, nucleotides), regulation of mitochondrial membrane potential and permeability, and mitochondrial fission, indicating a cohesive group involved in mitochondrial transport and membrane dynamics. A few terms like cell division and pregnancy appear but are not central to the dominant mitochondrial transport/dynamics theme. ","confidence":"High","size":22,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:1990544","count":2},{"id":"GO:0006843","count":2},{"id":"GO:0070542","count":2},{"id":"GO:0051881","count":2}]},{"hash":"1388881431224172508","title":"Oligodendrocyte differentiation and neural development","description":"This cluster is dominated by GO terms related to glial and neural development, notably oligodendrocyte differentiation and nervous system development, with supporting terms like cell adhesion and signaling regulation, suggesting a neural-glial developmental theme. Some terms appear incidental (e.g., molting/cuticle, fibrinolysis), but the core signal points to glial differentiation and neural maturation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048709","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0048265","count":2},{"id":"GO:0018996","count":2}]},{"hash":"681390379743198408","title":"Cartilage and bone development with ECM remodeling","description":"The top terms cluster around cartilage development, endochondral ossification, collagen fibril organization, collagen catabolic process, and integrin biosynthetic process, all pointing to extracellular matrix production and remodeling during skeletal formation. Other terms appear incidental but do not override the dominant ECM/skeletal theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071230","count":9},{"id":"GO:0070208","count":8},{"id":"GO:0033034","count":8},{"id":"GO:0060351","count":8},{"id":"GO:0045112","count":8}]},{"hash":"179132599444327387","title":"Developmental signaling and neural-immune responses","description":"This cluster shows enrichment across diverse signaling and developmental processes spanning immune signaling (T cell receptor pathway, LPS response), endocrine signaling (insulin receptor signaling, glucose import), and neural development/regeneration (heart and cerebellar cortex formation, axon regeneration, cocaine response). The common thread is broader regulatory signaling relevant to development and neural-immune contexts rather than a single, cohesive pathway, so the label reflects a multisystem signaling/regulatory theme rather than a precise function. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":8},{"id":"GO:2001275","count":8},{"id":"GO:0007507","count":7},{"id":"GO:0042220","count":7},{"id":"GO:0071222","count":7}]},{"hash":"1356070027685738357","title":"Vacuolar amino acid transporters","description":"The top GO terms point to transmembrane transport of multiple amino acids into and out of the vacuole (e.g., arginine, serine, proline, tyrosine, asparagine), indicating a cohesive set of proteins functioning in vacuolar amino acid transport. Although a couple of terms are obsolete or unrelated, the dominant signal is clear.","confidence":"High","size":22,"edges":79,"triangles":43,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0045818","count":1},{"id":"GO:0061402","count":1},{"id":"GO:1901482","count":1},{"id":"GO:0090516","count":1},{"id":"GO:0006867","count":1}]},{"hash":"757289916458880786","title":"Neurotransmitter GPCR Signaling in Cardiovascular Development","description":"The top GO terms center on GPCR signaling pathways that inhibit adenylate cyclase (opioid and dopamine receptors) and include octopamine/tyramine signaling, along with vasodilation mechanisms and development of heart and lung tissue. Together, they suggest a theme where neurotransmitter signaling interfaces with cardiovascular regulation and organ morphogenesis. Electron transport chain appears incidental but does not override the core theme. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0031635","count":18},{"id":"GO:0008284","count":18},{"id":"GO:0002025","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0021853","count":18}]},{"hash":"521706053014482724","title":"DNA Replication and MAPK Signaling","description":"This cluster centers on DNA-level processes (DNA replication, DNA-templated transcription, mitotic spindle organization) alongside MAPK signaling, indicating coordinated cell cycle control and signaling. Other terms such as apoptosis and telomere maintenance fit within general cell fate and genome integrity during proliferation, reinforcing a theme of DNA-directed cell growth with signaling regulation. Therefore the label DNA Replication and MAPK Signaling captures the main shared function.","confidence":"Medium","size":22,"edges":34,"triangles":9,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0007232","count":3},{"id":"GO:0050798","count":3},{"id":"GO:0097156","count":3}]},{"hash":"1816328715417350010","title":"Synaptic organization and spine morphogenesis","description":"Most terms cluster around synapse assembly and structure (dendritic spine morphogenesis, protein localization to synapse, receptor clustering) and cytoskeletal signaling (Rho signaling) relevant to neuronal communication. Other terms (innate immune response, cadmium response, cholesterol biosynthesis, visual learning) are less central but may reflect broader cellular stress, metabolism, or learning-related contexts. ","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0060997","count":5},{"id":"GO:0035418","count":5}]},{"hash":"2295528800030299584","title":"Oocyte Maturation and Spindle Assembly","description":"Based on the prominent GO terms, the cluster centers on meiotic processes in oocytes, including maturation (GO:0001556) and spindle assembly in female meiosis I (GO:0007057), with supporting microtubule dynamics (GO:0046785). The presence of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146) and ubiquitin-regulated mitotic processes suggests coordinated proteolysis during meiosis. While some developmental terms appear, the strongest common theme is meiosis/oocyte maturation and spindle-driven chromosome segregation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":6},{"id":"GO:0046785","count":6},{"id":"GO:0021678","count":6},{"id":"GO:0021993","count":6},{"id":"GO:0070544","count":6}]},{"hash":"2100255182735034115","title":"Developmental Regulation and Stress Response","description":"This cluster features strong signals for development (forebrain and skeletal system development, angiogenesis) along with transcriptional regulation and cellular stress responses (DNA-templated transcription, ER stress\u2013induced apoptotic signaling, cadmium response). The combination suggests proteins that coordinate developmental programs with stress signaling and immune-related responses, rather than a single narrow pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0050830","count":8},{"id":"GO:0001525","count":8},{"id":"GO:0046826","count":8},{"id":"GO:0008285","count":7}]},{"hash":"997713695620622089","title":"RNA processing and mRNA metabolism","description":"Most top GO terms cluster around maturation and handling of mRNA\u2014splicing via spliceosome, mRNA export, modification, regulation of polyadenylation, and translation reinitiation, as well as stress-related mRNA stability. This pattern indicates a set of proteins focused on RNA processing and mRNA metabolism rather than a single pathway, justifying the label.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":5},{"id":"GO:1902625","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001825","count":3}]},{"hash":"655594865390443370","title":"RNA processing and translation control","description":"This cluster is dominated by post-transcriptional activities: mRNA export, splicing regulation, mRNA modification and stability, and multiple modes of translation control (translation reinitiation, IRES-dependent initiation, miRNA-mediated silencing). The GO terms converge on RNA processing and translational regulation, suggesting a cohesive module despite a few unrelated terms.","confidence":"High","size":22,"edges":16,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1902625","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001825","count":2},{"id":"GO:0010610","count":2},{"id":"GO:1903586","count":2}]},{"hash":"1004287106828644578","title":"Diverse Metabolite Biosynthesis","description":"The top GO terms cluster around biosynthetic processes across multiple pathways (carbohydrate metabolism, lipoteichoic acid production, antibiotic synthesis, lignin and flavonoid biosynthesis, glycosylation). This suggests a shared theme of enzymes involved in producing or modifying small molecules and cell envelope components rather than a single pathway.","confidence":"Medium","size":22,"edges":19,"triangles":2,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":8},{"id":"GO:0070395","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0009808","count":6},{"id":"GO:0033485","count":6}]},{"hash":"1981918194721300589","title":"Transcriptional Regulation of Immune and Developmental Processes","description":"The cluster is centered on DNA-templated transcription, with several terms tying to immune signaling (LPS response, NF-kappaB regulation, inflammatory response) and to tissue development (mammary gland alveolus development, Leydig cell differentiation, myeloid progenitor proliferation), suggesting proteins that regulate transcription to coordinate immune responses and developmental programs.","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0060749","count":13},{"id":"GO:0033327","count":13},{"id":"GO:0035902","count":11},{"id":"GO:0071222","count":11}]},{"hash":"1879383743767680118","title":"Membrane transport and lipid barrier biosynthesis (plants)","description":"This cluster is dominated by transmembrane transport terms for vitamins and xenobiotics, as well as plant-specific lipid barrier processes like cutin transport and suberin biosynthesis, pointing to a cohesive theme of membrane transport coupled with lipid barrier formation. Some terms (visual perception, muscle development, Type I secretion) seem peripheral or noisy, but the core signal is membrane transport and lipid barrier biosynthesis. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0007601","count":2},{"id":"GO:0042694","count":2}]},{"hash":"2027369438602948973","title":"Unknown","description":"The GO terms are scattered across diverse processes (immune signaling, developmental pathways, transport and metabolism, peroxisome autophagy, stress responses) with no single cohesive theme. This makes it hard to assign a precise, representative label to the cluster.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0070236","count":1},{"id":"GO:0008101","count":1},{"id":"GO:0048642","count":1},{"id":"GO:0036335","count":1}]},{"hash":"519832154094150464","title":"Amino acid and fatty acid catabolism with quinone biosynthesis","description":"The cluster is enriched for multiple catabolic processes of amino acids (alanine, kynurenine, valine, phenylacetate, lysine) and fatty acid beta-oxidation, along with phylloquinone and menaquinone biosynthesis, indicating a focus on central metabolism and electron-carrier cofactor production. Notch signaling and antibiotic biosynthesis appear among top terms but are less representative; they may reflect annotations or cross-talk rather than a core functional theme. Overall, the label emphasizes catabolic metabolism and quinone production.","confidence":"Medium","size":22,"edges":29,"triangles":56,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":10},{"id":"GO:0007219","count":8},{"id":"GO:0042853","count":8},{"id":"GO:0097053","count":8},{"id":"GO:0006635","count":7}]},{"hash":"1762592484337932833","title":"Unknown","description":"The GO terms here cover many distinct processes (translation, transcription, immune development, receptor signaling, actin binding, mitotic cohesion) with no single shared function evident. The lack of interconnected edges and the broad mix suggest a heterogeneous set rather than a cohesive pathway, so a specific label is not justifiable.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0007064","count":3},{"id":"GO:0043113","count":2},{"id":"GO:0048011","count":2}]},{"hash":"818428351580022181","title":"Neural development and signaling pathways","description":"The cluster is enriched for nervous system development terms (nervous system development, brain development, dendrite morphogenesis) and key signaling pathways (Roundabout/Slit-Robo and Smoothened/Hedgehog), plus synaptic vesicle exocytosis regulation, indicating a cohesive theme of neural development and neuronal signaling.","confidence":"High","size":22,"edges":117,"triangles":187,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":9},{"id":"GO:0001822","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0007420","count":5},{"id":"GO:0035385","count":5}]},{"hash":"1836300997152605059","title":"Potassium Transport and Membrane Potential Regulation","description":"The cluster is driven by potassium ion homeostasis and membrane potential regulation terms (intracellular K+ homeostasis, K+ transmembrane transport, resting potential regulation, and membrane repolarization), with a few outliers related to touch sensation and skeletal development.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006486","count":6},{"id":"GO:0007341","count":4},{"id":"GO:0030322","count":3},{"id":"GO:0098914","count":3},{"id":"GO:0030007","count":3}]},{"hash":"972449326650871875","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":3},{"id":"GO:0070121","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042048","count":2},{"id":"GO:0007601","count":2}]},{"hash":"967588287687265234","title":"Ubiquitin-regulated organ morphogenesis","description":"The cluster features strong enrichment for ubiquitination-related processes (K63- and K48-linked ubiquitination, ubiquitin-dependent ERAD, protein catabolic processes, and autoubiquitination) alongside developmental/morphogenetic terms (left ventricular heart tissue morphogenesis, pulmonary valve morphogenesis, ossification, and multicellular organism development). This suggests a coherent theme of ubiquitin-mediated regulation guiding organ development and tissue differentiation, including signaling interactions such as NF-kappaB, rather than random functional grouping. Confidence reflects the clear, albeit broad, link between ubiquitination dynamics and developmental processes in the GO terms.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070534","count":2},{"id":"GO:0003220","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0043123","count":2}]},{"hash":"1235549234199356896","title":"Neuronal Synaptic Signaling and Memory","description":"The top GO terms point to neuronal communication and cognitive processes: glutamatergic synaptic transmission, long-term memory, visual learning, and social behavior. While some signaling pathways like EGFR and insulin signaling appear, the dominant theme centers on neuronal signaling and plasticity, with ubiquitination/ERAD-related terms possibly reflecting synaptic protein turnover. Overall, the cluster coherently maps to neuronal signaling and memory-related functions.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038028","count":2},{"id":"GO:0045945","count":2},{"id":"GO:0007173","count":2},{"id":"GO:0007616","count":2},{"id":"GO:0035176","count":2}]},{"hash":"1678985190524598539","title":"Proteolysis and ECM Remodeling","description":"The GO terms collectively point to proteolytic processes and extracellular matrix turnover, including fibrinolysis, regulation of plasminogen activation, bradykinin catabolic process, and blood coagulation, as well as extracellular matrix secretion and collagen-related remodeling. A few terms touch on developmental or regenerative contexts (Purkinje cell differentiation, liver regeneration, molting cycle), which can involve tissue remodeling and proteolysis. While the proteins have no reported interactions in this cluster, the common thread is proteolysis/ECM remodeling activity rather than a single, tightly connected pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":1},{"id":"GO:0003331","count":1},{"id":"GO:0010757","count":1},{"id":"GO:0021702","count":1},{"id":"GO:0097421","count":1}]},{"hash":"310831112112754184","title":"Unknown","description":"The terms are highly diverse (germline development, foregut morphogenesis, transmembrane transport, ischemia and anesthetic responses, and IL-1 production regulation) with no clear shared function, and the cluster has no edges, suggesting no cohesive biological theme. Therefore, Unknown is the most appropriate label.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030727","count":1},{"id":"GO:0051390","count":1},{"id":"GO:0072347","count":1},{"id":"GO:0055085","count":1},{"id":"GO:0050718","count":1}]},{"hash":"953651695268370071","title":"Gene Expression and Cell Growth Regulation","description":"This cluster\u2019s top GO terms converge on RNA processing and translation (formation of translation preinitiation complex, translation reinitiation, mRNA splicing, viral mRNA export) alongside growth-related processes (multicellular organism growth, SREBP signaling, regulation of cell cycle checkpoint, positive regulation of cell population proliferation). The involvement of ubiquitin ligase activity and histone methylation hints at coordinated regulation of protein turnover and chromatin state that can modulate gene expression and cell-cycle control. Collectively, these proteins likely participate in linking gene expression machinery with signals governing cell growth and proliferation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001731","count":9},{"id":"GO:0046784","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0035264","count":8},{"id":"GO:0032933","count":8}]},{"hash":"567932072612158132","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":1},{"id":"GO:0002107","count":1},{"id":"GO:0010606","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0006261","count":1}]},{"hash":"1755829861504286611","title":"Multisubstrate Membrane Transporters","description":"The top GO terms are all about transmembrane transport of a wide variety of substrates (sugars like galactose and arabinose, nitrate, phosphate, vitamins, xenobiotics, 4-hydroxyphenylacetate, sodium ions, etc.), plus a term for neurotransmitter loading into synaptic vesicles. This indicates the proteins function broadly as membrane transporters handling multiple solutes, rather than a single substrate class.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0015751","count":3},{"id":"GO:0015706","count":3}]},{"hash":"858855162614914344","title":"Unknown","description":"The top GO terms cover a wide range of processes (muscle and nervous system development, angiogenesis, immune signaling, DNA repair and transcription, ubiquitin-mediated proteolysis, LPS response, and spindle/axon regulation), with no single coherent function uniting all 22 proteins. The lack of edges further suggests heterogeneous roles, so a specific shared function label isn\u2019t evident.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007519","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0006351","count":3}]},{"hash":"836438527370043344","title":"Negative regulation of inflammatory signaling","description":"The cluster shows a clear pattern of GO terms related to dampening immune signaling, including negative regulation of NF-kappaB transcription factor activity, negative regulation of TNF and interferon-beta production, and responses related to IL-1 and LPS pathways. This points to proteins that function as inhibitors or modulators of inflammatory signaling. A couple of terms about development or circulation appear incidental and don\u2019t redefine the main theme. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0000060","count":1},{"id":"GO:0035775","count":1},{"id":"GO:0035025","count":1},{"id":"GO:0008015","count":1}]},{"hash":"2188953580858153215","title":"Copper Ion Transport and Homeostasis","description":"This cluster is dominated by GO terms related to copper handling in the cell: copper ion import across the plasma membrane, intracellular copper ion homeostasis, and regulation of copper ion transmembrane transport, pointing to a core function in copper transport and balance. Additional terms about ER membrane targeting and membrane transport fit with the idea of metal transporter proteins and secretory pathway involvement, while xenobiotic transport and cisplatin response align with transporter activity in metal coordination. Overall, the recurring copper-related terms suggest a cohesive theme around copper ion transport and homeostasis rather than a broad mix of unrelated processes.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007606","count":1},{"id":"GO:0071816","count":1},{"id":"GO:0048767","count":1},{"id":"GO:0015680","count":1},{"id":"GO:0098705","count":1}]},{"hash":"855988867266022663","title":"Insect reproductive and larval behavior regulation","description":"Strong enrichment for GO terms related to regulation of female receptivity, egg-laying behavior, and larval locomotion points to a core theme of controlling reproductive and developmental behaviors in insects. Some other terms reflect signaling and metabolic processes, but the dominant pattern is behavioral regulation tied to reproduction and larval movement.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045434","count":8},{"id":"GO:0048042","count":8},{"id":"GO:0002209","count":8},{"id":"GO:1901045","count":8},{"id":"GO:0008345","count":8}]},{"hash":"263917942220862338","title":"Olfactory sensing and related behavioral responses","description":"This cluster is dominated by GO terms for detection of chemical stimuli involved in sensory perception and olfactory behavior, suggesting a core theme of olfactory sensing guiding behavior. Several related terms point to reproductive and larval locomotion behaviors, indicating that olfactory cues influence mating, egg-laying, and movement, with a few outliers likely annotating broader roles of the proteins. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":7},{"id":"GO:0042048","count":6},{"id":"GO:0045434","count":3},{"id":"GO:0048042","count":3},{"id":"GO:0002209","count":3}]},{"hash":"2139246799398696452","title":"Rab/Rap-dependent endosomal transport and autophagy","description":"This cluster\u2019s top GO terms center on endosomal trafficking and signaling through Rab and Rap families, including endosome-to-Golgi transport, plus-end-directed vesicle movement along microtubules, plasma membrane to endosome transport, and regulation of autophagosome maturation. These collectively point to a cohesive function in vesicle trafficking and autophagy-related processes rather than generic signaling, justifying a label focused on endosomal transport and autophagy regulation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032483","count":1},{"id":"GO:1901098","count":1},{"id":"GO:0035556","count":1},{"id":"GO:0048227","count":1},{"id":"GO:0043553","count":1}]},{"hash":"2092084609200899006","title":"Thermoregulation and neurovascular signaling","description":"This cluster shows a concentration of GO terms related to temperature response and thermogenesis, pain signaling, and vascular regulation (norepinephrine/epinephrine- and angiotensin-mediated vasodilation, octopamine signaling), suggesting a shared theme around thermoregulation coupled with neural and vascular control. Some metabolic or developmental terms appear, but the dominant signal is heat/pain response linked to vascular tone.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0002024","count":9},{"id":"GO:0031635","count":8},{"id":"GO:0008284","count":8}]},{"hash":"834788996201608804","title":"Integrin signaling and ECM remodeling","description":"The cluster centers on integrin-mediated signaling, calcium-independent cell-matrix adhesion, substrate-dependent cell migration, and negative regulation of extracellular matrix assembly, which together point to a cohesive theme of cell-ECM adhesion and remodeling. Additional terms around proteasome assembly and ubiquitin-dependent protein catabolic processes suggest coupling to protein turnover that often accompanies signaling and adhesion regulation. Some terms (like chlorophyll biosynthetic process) look like outliers, and immune-related terms (T cell activation, blood coagulation) may reflect broader signaling contexts rather than a single pathway. Overall, the core theme is integrin- and ECM-associated signaling and remodeling with related proteostasis.","confidence":"Medium","size":21,"edges":22,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":4},{"id":"GO:0007229","count":3},{"id":"GO:0043248","count":3},{"id":"GO:0006929","count":3},{"id":"GO:1901202","count":3}]},{"hash":"286415995334368914","title":"Ribosome Biogenesis and RNA Splicing","description":"Genes in this cluster are enriched for rRNA maturation (SSU/LSU/5.8S) and spliceosome-mediated mRNA processing, including ncRNA-mediated regulation. This points to a core theme of nucleolar ribosome biogenesis and RNA maturation/splicing, with some related DNA replication/transcription-related processes likely reflecting shared nuclear functions.","confidence":"High","size":21,"edges":195,"triangles":1070,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0006369","count":7},{"id":"GO:0019079","count":6},{"id":"GO:0000462","count":6},{"id":"GO:0000463","count":5}]},{"hash":"2088947897821310810","title":"Dopaminergic signaling and sensory perception","description":"This cluster centers on nervous system signaling and perception: dopaminergic synaptic transmission, visual perception and learning, sensory pain perception, and cocaine-related behavioral responses, all pointing to neural signaling and sensory/behavioral processing. ERK1/2 cascade regulation supports neuronal signaling and plasticity, reinforcing the neural theme; incidental terms like saliva secretion and heart development are less aligned but may reflect broader pleiotropic roles. ","confidence":"Medium","size":21,"edges":94,"triangles":105,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":14},{"id":"GO:0019233","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0010759","count":13},{"id":"GO:0071380","count":13}]},{"hash":"2288952596363747990","title":"Plant lipid metabolism and ABA/osmotic stress response","description":"The GO terms cluster around phosphatidylinositol and inositol phosphate biosynthesis, indicating lipid signaling pathways common in plants. The presence of abscisic acid-activated signaling and hyperosmotic salinity response strongly points to plant-specific stress signaling, while pectin catabolic process and gluconeogenesis suggest broader plant metabolic remodeling. Overall, the cluster seems to reflect plant lipid metabolism linked to stress response and metabolic adaptation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046854","count":2},{"id":"GO:0009738","count":2},{"id":"GO:0046855","count":2},{"id":"GO:0006094","count":2},{"id":"GO:0000103","count":2}]},{"hash":"1189072630271775169","title":"Unknown","description":"The set spans diverse processes from retinoid metabolism and hematologic activation to cytoskeletal assembly, RNA silencing, and multiple signaling pathways, with no clear single function tying the proteins together. This heterogeneity makes a cohesive, intuitive label unlikely.","confidence":"","size":21,"edges":186,"triangles":958,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":8},{"id":"GO:0042574","count":7},{"id":"GO:0070527","count":6},{"id":"GO:0051017","count":6},{"id":"GO:0006069","count":5}]},{"hash":"2187948642571360698","title":"Developmental Signaling and Differentiation","description":"These top GO terms cluster around embryonic development across multiple tissues (ectoderm formation, gonad and pancreatic cell development, nephrogenesis) and related signaling/regulatory processes (growth hormone signaling, NF-kB signaling, miRNA-mediated silencing). This suggests a broader theme of developmental differentiation guided by signaling networks, with a few terms potentially reflecting accompanying vascular or immune contexts. ","confidence":"Medium","size":21,"edges":83,"triangles":143,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":8},{"id":"GO:0008585","count":8},{"id":"GO:0035195","count":7},{"id":"GO:0008588","count":7},{"id":"GO:0035995","count":7}]},{"hash":"1651482933076690126","title":"Neurodevelopment and Axon Guidance","description":"This cluster is anchored by explicit neuronal development terms, including neuron development and fasciculation of sensory neuron axons, with supporting signals related to cytoskeletal regulation (GTPase activity) and differentiation (DNA-templated transcription). While other terms (ribosome biogenesis, cholesterol biosynthesis) are more general, they align with the metabolic and biosynthetic needs of developing neurons, reinforcing the neurodevelopment theme.","confidence":"High","size":21,"edges":14,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0043087","count":2},{"id":"GO:0032435","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0042254","count":2}]},{"hash":"873962615545074391","title":"Wound Healing, Adhesion, and Immune Regulation","description":"These proteins show a theme around tissue repair and immune-related processes: cadherin-mediated cell\u2013cell adhesion, wound healing and epithelial proliferation involved in repair, leukocyte migration, and innate immune responses, plus related tissue remodeling like vascular smooth muscle proliferation and endochondral ossification. While the set includes diverse contexts (e.g., pregnancy, ossification), the common thread is organization of cell adhesion and coordinated repair with immune involvement.","confidence":"Medium","size":21,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0044331","count":1},{"id":"GO:0060135","count":1},{"id":"GO:0045579","count":1},{"id":"GO:0050900","count":1},{"id":"GO:1904707","count":1}]},{"hash":"736384844854760413","title":"Actin cytoskeleton remodeling and spine morphogenesis","description":"This cluster is dominated by actin-related terms (actin cytoskeleton organization, lamellipodium assembly, barbed-end capping, actin polymerization) and dendritic spine morphogenesis, indicating a core theme of actin remodeling linked to spine formation, with some accompanying membrane transport terms that are less central.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":3},{"id":"GO:0030036","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0030032","count":2}]},{"hash":"808732687438255589","title":"Unknown","description":"The top GO terms span broad metabolism (oxidation-reduction, PPP, TCA cycle, glycogen biosynthesis) and neural development/dopamine pathways (striatum/thalamus development, dopamine catabolic process), with no obvious cohesive function tying all proteins together and no edge-based connections, so a single interpretable label isn\u2019t supported. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0009820","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0005978","count":3},{"id":"GO:0006098","count":3}]},{"hash":"1539518863786209332","title":"Inflammation and developmental signaling","description":"Top GO terms indicate a strong involvement in innate immune response to lipopolysaccharide and the p38 MAPK cascade, coupled with DNA-templated transcription. Simultaneously, multiple terms reference placental and reproductive tissue development and other developmental processes (retinoic acid response, chondrocyte growth). This suggests a cluster of proteins that participate in inflammatory signaling that can interface with developmental regulatory programs in certain tissues, rather than a single, tightly cohesive pathway. ","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":13},{"id":"GO:0006351","count":13},{"id":"GO:2001275","count":12},{"id":"GO:0038066","count":12},{"id":"GO:0001890","count":12}]},{"hash":"1642669163923178642","title":"Embryonic organ morphogenesis","description":"The GO terms center on developmental processes across multiple organs (heart, eye, limb, placenta, brain habenula, muscle precursors, prostate), indicating proteins involved in embryonic organogenesis and tissue patterning rather than a single pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":9},{"id":"GO:0021986","count":9},{"id":"GO:0003148","count":8},{"id":"GO:0035116","count":8},{"id":"GO:0008584","count":8}]},{"hash":"61540163340513054","title":"COPII Vesicle Transport and Mitosis","description":"The top GO terms are dominated by COPII-coated vesicle budding and Golgi-to-ER retrograde transport, alongside mitotic spindle assembly, mitotic cell cycle, cell division, and growth. This points to proteins involved in membrane trafficking that also participate in cell cycle progression and organismal growth, justifying a label that reflects both trafficking and mitotic roles.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090114","count":7},{"id":"GO:0090307","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0006890","count":4}]},{"hash":"753324237080030808","title":"RNA processing and translation regulation","description":"The cluster is defined by GO terms focused on mRNA processing and splicing (spliceosome-mediated splicing, polyadenylation, deadenylation-dependent decay) and by negative regulation of cytoplasmic translation, pointing to a cohesive role in post-transcriptional RNA metabolism and control of protein synthesis. Some ancillary terms (e.g., T cell proliferation regulation, response to raffinose) appear peripheral to the core RNA-processing theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006378","count":7},{"id":"GO:0045292","count":7},{"id":"GO:0098789","count":4},{"id":"GO:0000381","count":4},{"id":"GO:0097403","count":3}]},{"hash":"74620463804083646","title":"Potassium Ion Transport and Membrane Potential Regulation","description":"The dominant GO terms are about potassium ion transport, intracellular potassium homeostasis, and stabilization/regulation of membrane potential, including cardiac atrial repolarization. This indicates a core theme of ion homeostasis and membrane excitability, with touch/pain terms likely reflecting neuron excitability rather than a separate function. Overall, the cluster seems to group proteins involved in potassium-driven membrane potential regulation and related ion homeostasis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071805","count":13},{"id":"GO:0050976","count":13},{"id":"GO:0098914","count":13},{"id":"GO:0060075","count":12},{"id":"GO:0030007","count":12}]},{"hash":"239340899982606247","title":"Developmental morphogenesis across tissues","description":"The proteins show multiple morphogenesis-related GO terms spanning neural, vascular, muscular, and organ development (e.g., angiogenesis, axon guidance, synapse assembly, and fin/artery morphogenesis), suggesting a broad developmental program rather than a single pathway. The lack of network edges implies diverse roles or annotations across different tissues.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002042","count":4},{"id":"GO:0048846","count":4},{"id":"GO:0048632","count":4},{"id":"GO:0007269","count":4},{"id":"GO:0007416","count":4}]},{"hash":"1792185116563225827","title":"Neuronal development and synaptic signaling","description":"Top GO terms show brain and hippocampus development alongside synaptic vesicle exocytosis, with supporting terms for gene expression regulation, TORC2 signaling, and phospholipid homeostasis. This suggests a cluster enriched for neuronal development and synaptic function rather than general cellular processes, despite one outlier term related to mating projection growth likely reflecting annotation noise. Overall, the label captures the main theme of neuronal development and synaptic activity.","confidence":"Medium","size":21,"edges":38,"triangles":7,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031384","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0021766","count":4},{"id":"GO:0051291","count":4},{"id":"GO:0010628","count":4}]},{"hash":"2201035167897717261","title":"Triglyceride metabolism and phospholipid remodeling","description":"Most terms cluster around triglyceride catabolism/mobilization and lipid remodeling, including triglyceride catabolic processes and acyl-chain remodeling, alongside phospholipid catabolic processes (phosphatidylethanolamine and phosphatidylcholine). A few terms touch on signaling or immune regulation, but the lipid turnover theme is clear and representative of the cluster. ","confidence":"High","size":21,"edges":14,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":3},{"id":"GO:0046338","count":3},{"id":"GO:0006642","count":3},{"id":"GO:2000480","count":3},{"id":"GO:0019433","count":3}]},{"hash":"922110769986483652","title":"Lipid metabolism and adipogenesis","description":"Most top GO terms cluster around lipid biology: response to fatty acids, sphingolipid biosynthesis and metabolism (sphingosine, sphinganine), and white fat cell differentiation. This combination points to a module involved in lipid biosynthesis/signaling and fat cell development, despite some obsolete terms. Therefore, the label Lipid metabolism and adipogenesis is appropriate.","confidence":"High","size":21,"edges":14,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":3},{"id":"GO:0034435","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0033561","count":2},{"id":"GO:0050872","count":2}]},{"hash":"720389670066983762","title":"Fatty acid biosynthesis and vesicle trafficking","description":"This cluster is driven by GO terms for fatty acid biosynthesis and elongation (long-chain and very long-chain fatty acids, fatty-acyl-CoA biosynthesis), indicating lipid metabolism as a core function. Concurrently, terms about post-Golgi vesicle transport and endosome-to-vacuole pathways point to membrane trafficking roles that may tie into lipid handling and organelle biology. Some olfactory-related terms appear as weaker signals, potentially reflecting pleiotropic proteins or annotation noise. Overall, the dominant theme combines lipid biosynthesis with vesicle trafficking.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042048","count":2},{"id":"GO:0050907","count":2},{"id":"GO:1904780","count":1},{"id":"GO:0045818","count":1},{"id":"GO:0042761","count":1}]},{"hash":"1891084876545544877","title":"Eye and heart development","description":"This cluster centers on developmental processes, especially eye formation (lens fiber differentiation and visual perception) and heart development, with supporting terms like mesoderm formation and craniofacial morphogenesis. Signaling pathways such as BMP and Rho also tie into broader embryonic organogenesis. Overall, the proteins appear linked to ocular and cardiac/craniofacial development, supporting the chosen label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":4},{"id":"GO:0070306","count":3},{"id":"GO:0018107","count":3},{"id":"GO:0010614","count":3},{"id":"GO:0001707","count":3}]},{"hash":"1316730871258891254","title":"Eye development and photoreceptor maintenance","description":"Dominant GO terms are about retina development, photoreceptor cell maintenance, and visual learning, indicating a coherent role in eye development and photoreceptor function; other terms are less central but do not override the vision-focused signal.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040015","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0006955","count":2}]},{"hash":"1786352961964368643","title":"Mitochondrial Translation and Respiratory Assembly","description":"The terms cluster around mitochondrial gene expression and energy metabolism: mitochondrial translation and LSU rRNA maturation, assembly of the respiratory chain (complex III) and proton motive force\u2013driven ATP synthesis, plus related protein complex oligomerization and ion transport. Ubiquitination and proteasome assembly hints suggest mitochondrial quality-control processes linked to assembly and turnover.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015986","count":5},{"id":"GO:0099132","count":4},{"id":"GO:0006412","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0016567","count":2}]},{"hash":"1834419002125409056","title":"Ubiquitin-Dependent Protein Degradation and DNA Replication Regulation","description":"This cluster is characterized by GO terms centered on ubiquitin-dependent proteolysis and proteasome-mediated degradation (including SCF-dependent pathways and polyubiquitination) and by terms related to regulation of DNA-templated DNA replication initiation and cell cycle transitions (G1/S). Stress-response terms to metals appear but the dominant signal ties protein turnover to cell cycle and replication control.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001556","count":2},{"id":"GO:0030174","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0046685","count":1},{"id":"GO:0070544","count":1}]},{"hash":"972048337769459637","title":"Drosophila circadian sleep and neuronal signaling","description":"It centers on circadian sleep regulation and neuronal signaling in Drosophila, with terms for sleep, circadian rhythm, odorant response, cholinergic synaptic transmission, and ion-channel regulation, suggesting a module focused on sleep-related neural activity and sensory signaling. Some insect-specific developmental terms likely reflect species context rather than core function.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":2},{"id":"GO:0035158","count":1},{"id":"GO:0048511","count":1},{"id":"GO:1903049","count":1},{"id":"GO:0030431","count":1}]},{"hash":"69456442687938978","title":"Cerebellar neural development and signaling","description":"The top GO terms cluster around cerebellar-specific development and neural signaling: cerebellar cortex formation, Bergmann glial cell differentiation, axonogenesis, and axon regeneration, with accompanying insulin receptor signaling and angiogenesis. While a T cell receptor signaling term appears, the dominant theme is cerebellar neural development and its associated signaling pathways, suggesting these proteins function in cerebellar development and neural connectivity.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0050852","count":13},{"id":"GO:0046826","count":13},{"id":"GO:0001525","count":12},{"id":"GO:2001275","count":12}]},{"hash":"2019592863974153866","title":"Embryonic morphogenesis and sensory signaling","description":"The top GO terms point to developmental morphogenesis (cranial skeleton morphogenesis, convergent extension, placenta development) and active signal transduction (Rho and small GTPase pathways, PI3K signaling), along with sensory perception components (olfactory behavior, detection of chemical stimuli). This suggests a cluster of proteins involved in embryonic development and associated signaling with a possible link to sensory system formation. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0042048","count":3},{"id":"GO:0050907","count":3},{"id":"GO:0060026","count":2}]},{"hash":"882465354289087217","title":"ER stress\u2013immune signaling cluster","description":"This cluster shows strong enrichment for endoplasmic reticulum stress responses and regulation of the unfolded protein response (including PERK-related pathways and ER-stress\u2013induced apoptotic signaling) along with immune signaling terms (adaptive immune response, T cell receptor signaling). While other terms like angiogenesis and cytoskeletal organization appear, the ER stress and immune-related terms provide the most coherent shared theme, justifying this label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0060020","count":3},{"id":"GO:0050852","count":3},{"id":"GO:1903898","count":3}]},{"hash":"1970147646280786369","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning maltose transport, ribosomal large subunit export from the nucleus, positive regulation of protein localization to the nucleolus, ER organization, developmental processes in the brain (substantia nigra and cerebellum), phosphorylation, intracellular chloride ion homeostasis, and phosphocreatine biosynthesis. With no edges or triangles and no clear shared function linking the 21 proteins, there isn\u2019t a unifying biological theme to assign a specific label.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015768","count":1},{"id":"GO:0000055","count":1},{"id":"GO:1904751","count":1},{"id":"GO:0007029","count":1},{"id":"GO:0040027","count":1}]},{"hash":"179094736776699840","title":"Golgi-ER Retrograde Transport and Golgi Organization","description":"The cluster\u2019s top GO terms cluster around transport from the Golgi to the endoplasmic reticulum, retrograde vesicle trafficking within the Golgi, and Golgi organization, with an additional autophagy-related Cvt pathway tag. These collectively point to a cohesive theme of Golgi-associated vesicle trafficking and organization, outweighing more peripheral signals like transcription or differentiation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032258","count":3},{"id":"GO:0045444","count":2},{"id":"GO:0031914","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006890","count":2}]},{"hash":"1294827143122445098","title":"Cardiac muscle development and neural maturation","description":"The top GO terms point to heart development and sarcomere organization, indicating a cardiac muscle/sarcomeric module. The presence of neural-related terms (nerve maturation, myelination, regulation of dendritic spine development) suggests a broader developmental program linking heart and nervous system processes. With no edges between proteins, the label reflects shared GO annotations rather than direct interactions.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0045214","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060445","count":2}]},{"hash":"344642686319852095","title":"Genome maintenance and stress response","description":"This cluster is rich in nuclear DNA processes: DNA-templated transcription, DNA replication, recombination, and DNA repair, plus negative regulation of protein export from the nucleus, suggesting core genome maintenance. The presence of apoptotic process and cellular responses to cadmium ion and redox homeostasis indicates activation of stress-response pathways alongside genome integrity maintenance. Overall, the dominant theme is genome maintenance with stress signaling, despite one less-connected term.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006310","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0071375","count":2}]},{"hash":"548737351121677062","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0009246","count":2},{"id":"GO:0050766","count":1},{"id":"GO:0006888","count":1}]},{"hash":"1660405015606716565","title":"Vacuolar amino acid transporters","description":"The Top Terms are dominated by transmembrane transport into the vacuole, with specific emphasis on amino acid import (lysine, arginine, tyrosine, proline, serine, etc.), suggesting a cohesive function as vacuolar amino acid transport proteins; the presence of some related but obsolete terms does not override the clear transport signature.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061402","count":1},{"id":"GO:1901482","count":1},{"id":"GO:0090516","count":1},{"id":"GO:0006867","count":1},{"id":"GO:1990818","count":1}]},{"hash":"2213504720712316093","title":"Cartilage ECM Formation and Remodeling","description":"The top GO terms cluster around cartilage development and endochondral ossification, collagen fibril organization and catabolic processes, and integrin biosynthesis, all pointing to extracellular matrix assembly/remodeling in cartilage and bone formation. This suggests the proteins function together in cartilage ECM organization and endochondral ossification.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3},{"id":"GO:0045112","count":3},{"id":"GO:0001958","count":3}]},{"hash":"579278778876057584","title":"Lipid Catabolism and Endocannabinoid Regulation","description":"This cluster is enriched for lipid-related catabolic processes (triglyceride and monoacylglycerol catabolism, phosphatidylserine catabolism) and includes regulation of endocannabinoid signaling, suggesting proteins involved in lipid breakdown and modulation of endocannabinoid pathways. While a few terms reflect biosynthesis or unrelated processes, the strongest signal centers on lipid metabolism and endocannabinoid signaling regulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000124","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0006660","count":4},{"id":"GO:0052651","count":4},{"id":"GO:0030245","count":4}]},{"hash":"1362868754542452811","title":"Mitotic DNA Replication and Chromosome Segregation","description":"This cluster is strongly enriched for mitosis, cell division, and DNA replication terms (mitotic cell cycle, cell division, DNA replication, mitotic sister chromatid segregation), with supporting signals from ATP-dependent activity and helicase regulation, which fit replication and chromosome maintenance during S and M phases. Some RNA processing terms appear, likely as background annotations, but the core theme centers on cell-cycle progression and chromosome segregation.","confidence":"High","size":20,"edges":12,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0032781","count":2},{"id":"GO:0051096","count":2},{"id":"GO:0002181","count":2}]},{"hash":"787690764720505102","title":"Oocyte meiosis and spindle assembly","description":"The cluster\u2019s top terms strongly center on meiotic processes, especially spindle assembly in female meiosis I and oocyte maturation, with supporting involvement of ubiquitin-proteasome\u2013mediated protein turnover and microtubule dynamics. Some neural-development terms appear as incidental annotations, but the core theme is meiotic progression and spindle control in oocytes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":9},{"id":"GO:0046785","count":9},{"id":"GO:0021678","count":9},{"id":"GO:0021993","count":9},{"id":"GO:0070544","count":9}]},{"hash":"2252726696213038986","title":"Cell Cycle and DNA Replication","description":"The top GO terms are centered on DNA replication, DNA-templated transcription, and the cell cycle, with additional entries for proliferation regulation and apoptosis, suggesting a core theme of cell growth and division. Some terms also touch on growth signaling and stress responses (filamentous growth, osmosensory signaling), which can influence cell cycle progression, supporting a cohesive view of cell cycle control and growth regulation across contexts.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0001402","count":3},{"id":"GO:0007232","count":3}]},{"hash":"928016037599715212","title":"mRNA processing and translation initiation","description":"The cluster is dominated by GO terms around mRNA export, translation initiation/reinitiation, preinitiation complex formation, and regulation of mRNA splicing and modification, indicating a cohesive module of post-transcriptional regulation and translation control. Despite a few peripheral or obsolete terms, the core functions point to coordinated mRNA maturation, export, and translation regulation, especially under stress.","confidence":"High","size":20,"edges":6,"triangles":0,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":6},{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0048026","count":5},{"id":"GO:1902625","count":4}]},{"hash":"2303181454334208985","title":"Developmental Transcriptional Regulation Across Tissues","description":"The TOP terms point to transcriptional processes (DNA-templated transcription, circadian regulation of gene expression) and development across multiple tissues (male gonad, placenta, heart outflow tract, habenula, cerebellar granule cell precursors, myoblasts). This suggests a cluster of proteins involved in regulating gene expression during development across diverse organ systems, rather than a single tissue-specific function.","confidence":"Medium","size":20,"edges":7,"triangles":0,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":10},{"id":"GO:0021930","count":10},{"id":"GO:0032922","count":9},{"id":"GO:0006351","count":9},{"id":"GO:2000288","count":9}]},{"hash":"1295825380818175292","title":"Membrane Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of ions (sodium, potassium) and various substrates (galactose, arabinose, nitrate, vitamins, xenobiotics), plus a vesicular neurotransmitter loading term. The pattern points to proteins that function as membrane transporters rather than enzymes or receptors, covering diverse substrates across different membranes. Hence, a label like \u201cMembrane Transporters\u201d captures the common function.","confidence":"High","size":20,"edges":26,"triangles":6,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":7},{"id":"GO:0071805","count":7},{"id":"GO:1900754","count":6},{"id":"GO:0035461","count":6},{"id":"GO:0015751","count":6}]},{"hash":"1899454457430125366","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0042273","count":2}]},{"hash":"1384957580897183470","title":"Plant jasmonate/oxylipin defense signaling","description":"This cluster shows jasmonic acid and oxylipin biosynthesis terms along with stress responses (toxic substances, ozone) and plant-specific processes (stamen development), suggesting lipid-mediated defense signaling and associated metabolism in plants.","confidence":"Medium","size":20,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":4},{"id":"GO:0019358","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0034418","count":3},{"id":"GO:0044209","count":3}]},{"hash":"1429171361587816878","title":"Adenylyl Cyclase\u2013Coupled GPCR Signaling","description":"The top terms strongly point to GPCR pathways that activate or inhibit adenylyl cyclase, driving cAMP signaling, with links to metabolism and physiological regulation (thermogenesis, blood pressure) as well as sensory responses (pain, temperature). While a few terms are broader, the core theme across multiple GO terms centers on AC-coupled GPCR signaling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0040015","count":7},{"id":"GO:0008542","count":7}]},{"hash":"2294759011716683579","title":"Embryonic organ morphogenesis","description":"The terms cluster around embryonic organ formation and morphogenesis across multiple tissues\u2014heart, eye, hindlimb, placenta, gonads, habenula\u2014and include regulatory processes like transcription control, suggesting a coherent role in embryonic organ morphogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":5},{"id":"GO:0035116","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0001890","count":5},{"id":"GO:2000288","count":5}]},{"hash":"2304578744150617661","title":"Neural Development and Synaptic Function","description":"Based on the top GO terms, this cluster shows strong enrichment for neural-related activities\u2014retina development, learning, synaptic vesicle clustering, and regulation of protein localization to synapses\u2014suggesting a theme of neural development and synaptic organization. While there are a few non-neural terms (osteoblast development, iodide transport, xenobiotic response), the neural/synaptic signals dominate, supporting this label as representative.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":12},{"id":"GO:0002087","count":12},{"id":"GO:0002076","count":12},{"id":"GO:0015705","count":9},{"id":"GO:0042493","count":9}]},{"hash":"1578048230856108405","title":"Organogenesis and Tissue Differentiation","description":"These proteins map to a wide range of developmental processes across multiple tissues\u2014bone, pancreas, heart, muscle, and nervous system\u2014along with regulatory signaling terms. The diverse but development-centered GO terms suggest a role in broad tissue differentiation rather than a single targeted function. Confidence: Medium","confidence":"","size":20,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":19},{"id":"GO:0060766","count":19},{"id":"GO:0031018","count":16},{"id":"GO:0035914","count":16},{"id":"GO:0003195","count":15}]},{"hash":"515095035958115816","title":"Golgi and endosome protein turnover","description":"The cluster features terms tied to protein handling in the Golgi (protein retention) and endosomal-lysosomal pathways (ubiquitin-dependent proteolysis via multivesicular bodies, general proteolysis). This points to a cohesive theme of protein processing, trafficking, and degradation within the Golgi/endosome system, rather than a single metabolic or developmental function. Some other terms (e.g., phosphorylation, methionine/threonine metabolism, developmental processes) appear incidental to the core trafficking/degradation theme. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019284","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0009088","count":2},{"id":"GO:0046677","count":2}]},{"hash":"471294669744282989","title":"Embryonic organogenesis","description":"The top terms are all embryonic development and morphogenesis across multiple organs (eye, heart/outflow tract, limb, placenta, habenula, prostate, etc.), suggesting these proteins participate in organ formation rather than a single pathway. ","confidence":"High","size":20,"edges":96,"triangles":151,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":12},{"id":"GO:0008584","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0003148","count":10},{"id":"GO:0035116","count":10}]},{"hash":"1278608183133392155","title":"Embryonic organogenesis and differentiation","description":"The cluster includes GO terms across development of multiple organs (heart, eye, placenta, prostate, ovary, habenula) and associated transcriptional regulation, suggesting a shared theme of embryonic organ development rather than a single tissue-specific pathway. Key terms include heart development, eye morphogenesis, placenta development, prostate gland morphogenesis, ovarian follicle growth, and DNA-templated transcription, supporting a cohesive developmental program.","confidence":"High","size":20,"edges":172,"triangles":862,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":12},{"id":"GO:0021986","count":12},{"id":"GO:0048048","count":12},{"id":"GO:0003148","count":11},{"id":"GO:0006351","count":11}]},{"hash":"1589259606714267335","title":"Meiosis and Mitosis Core Machinery","description":"The top terms are strongly centered on meiotic and mitotic cell cycle processes, including meiotic cell cycle, G1/S transition of mitotic cell cycle, kinetochore localization, and DNA replication, indicating a cluster of proteins involved in chromosome duplication and segregation. A few neural-related terms appear but do not outweigh the core cell cycle theme.","confidence":"High","size":20,"edges":45,"triangles":27,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051321","count":13},{"id":"GO:0000082","count":13},{"id":"GO:0034501","count":13},{"id":"GO:0006260","count":13},{"id":"GO:0014044","count":13}]},{"hash":"384498729718914410","title":"Protein acetylation and polyamine metabolism","description":"The cluster is centered on acetylation-related GO terms (peptidyl-lysine N6-acetylation; N-terminal peptidyl-serine/methionine acetylation) and acetylation of polyamines (spermidine/spermine), suggesting a cohesive theme around protein modification by acetylation and related polyamine metabolism, with other terms like melatonin or angiogenesis appearing as ancillary associations.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":9},{"id":"GO:0018003","count":9},{"id":"GO:0019491","count":8},{"id":"GO:0030187","count":8},{"id":"GO:0006348","count":8}]},{"hash":"751382613227725379","title":"Unknown","description":"The GO terms include photoreceptor maintenance, inflammatory response, multiple neurotransmitter signaling pathways (dopamine, octopamine/tyramine, adrenergic-related), vasodilation and blood pressure regulation, neuron migration, cell proliferation, and mitochondrial electron transport. This broad mix across vision, neural development, signaling, vascular and metabolic processes does not point to a single cohesive function for the entire cluster, so a specific, representative label cannot be reliably assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":5},{"id":"GO:0006954","count":5},{"id":"GO:0031635","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0002025","count":4}]},{"hash":"1577405860581539907","title":"Potassium transport and membrane potential regulation","description":"Dominant terms point to potassium handling and membrane potential control (K+ transport, membrane stabilization, resting potential, K+/Mg2+ homeostasis, cardiac action potential repolarization). A few sensory and motility terms are present but do not redefine the cluster; the main theme is ion transport governing excitable membranes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098914","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0050976","count":8},{"id":"GO:0030322","count":7},{"id":"GO:0030007","count":7}]},{"hash":"161973224261774590","title":"Innate Immune Signaling","description":"This cluster is dominated by GO terms for Toll-like receptor signaling (TLR3/7/9) and positive regulation of IL-1\u03b2 production, indicating an innate immune response module. Some development-related terms (Sertoli cell, heart development) and nerve impulse transmission appear as less cohesive or incidental associations, but the core theme centers on innate immune signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060009","count":2},{"id":"GO:0034154","count":2},{"id":"GO:0019226","count":2},{"id":"GO:0050718","count":2},{"id":"GO:0007507","count":2}]},{"hash":"2191054382613867574","title":"Unknown","description":"The top GO terms are a mix: transcriptional repression, acute-phase response, and ER-associated processes (with several terms obsolete). There isn\u2019t a single, cohesive function tying all 20 proteins together, so a clear, specific cluster name isn\u2019t supported by the data.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0006953","count":2},{"id":"GO:2000344","count":2},{"id":"GO:0098869","count":1}]},{"hash":"1495318294542946928","title":"Epigenetic Regulation of Gene Expression","description":"Most GO terms point to control of transcription and chromatin state, such as negative regulation of gene expression via DNA cytosine methylation, histone demethylation, and heterochromatin formation. Although a few terms relate to neural signaling or apoptosis, the recurring theme across the set appears to be epigenetic regulation of gene expression and chromatin modification rather than a single cohesive cellular pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":2},{"id":"GO:1905524","count":1},{"id":"GO:0097190","count":1},{"id":"GO:1900189","count":1},{"id":"GO:0031452","count":1}]},{"hash":"311896660220314701","title":"Lipid and hormone biosynthesis","description":"This cluster is best described as lipid- and hormone-biosynthesis due to the strong enrichment for fatty acid elongation, very long-chain fatty acids, retinoic acid and testosterone biosynthesis, and related lipophilic vitamin metabolism (phylloquinone); other terms are peripheral but do not override this theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0031427","count":20},{"id":"GO:0042761","count":20},{"id":"GO:0030497","count":20},{"id":"GO:0042376","count":20},{"id":"GO:0061370","count":20}]},{"hash":"2133241148324777977","title":"Mitochondrial energy metabolism and amino acid catabolism","description":"The GO terms point to mitochondrial NADH dehydrogenase\u2013related electron transport, lipoate/dihydrolipoamide\u2013dependent metabolic steps, and catabolic processes for several amino acids (valine, isoleucine, lysine) and related intermediates, plus 2-oxoglutarate. Together, they highlight mitochondrial energy production pathways and amino acid breakdown mechanisms, suggesting a cluster of proteins involved in energy metabolism linked to mitochondrial enzyme complexes. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0009106","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0006574","count":1},{"id":"GO:0051068","count":1}]},{"hash":"167515554457093831","title":"Endochondral bone formation and ECM remodeling","description":"The cluster is enriched for cartilage development and endochondral ossification terms (cartilage development involved in endochondral bone morphogenesis, endochondral ossification) along with collagen fibril organization and collagen catabolic processes, indicating extracellular matrix remodeling during skeletal development. Supporting terms like integrin biosynthetic process further point to cell-ECM interactions; a few miscellaneous terms are present but do not outweigh the ECM/ossification signal.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":5},{"id":"GO:0033034","count":5},{"id":"GO:0060351","count":5},{"id":"GO:0045112","count":5},{"id":"GO:0001958","count":5}]},{"hash":"1175436036115182996","title":"Meiosis and Oocyte Maturation","description":"The top GO terms strongly point to meiotic processes and oocyte development (spindle assembly in female meiosis I, oocyte maturation), supported by ubiquitin-proteasome\u2013mediated protein turnover and microtubule dynamics that regulate the cell cycle. While some terms relate to broader development and chromatin modification, the cohesive theme centers on meiosis/oocyte maturation and associated cell-cycle control, making this a concise and representative label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":9},{"id":"GO:0070544","count":8},{"id":"GO:0007057","count":8},{"id":"GO:0021993","count":8},{"id":"GO:0008285","count":8}]},{"hash":"1471732089649750298","title":"Calcium-dependent development in muscle, bone, and neurons","description":"GO terms indicate developmental processes in bone and cardiac muscle, vascular growth, and neuronal differentiation, with explicit calcium signaling components (calcium ion detection and ryanodine receptor activity). This suggests the proteins participate in calcium-driven developmental signaling across musculoskeletal, cardiovascular, and neural systems.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0001525","count":1},{"id":"GO:0005513","count":1},{"id":"GO:0060316","count":1}]},{"hash":"1708865420349094184","title":"Oocyte Meiosis and Spindle Assembly","description":"This cluster is dominated by terms related to oocyte maturation and female meiosis I spindle assembly, including GO:0001556 (oocyte maturation) and GO:0007057 (spindle assembly involved in female meiosis I), along with microtubule polymerization (GO:0021678) and SCF-dependent ubiquitin-proteasomal protein degradation (GO:0031146). Together, these indicate a cohesive theme centered on meiotic progression in oocytes and the associated cytoskeletal dynamics and proteolysis. Some neural development terms appear as noise, but the strongest signal is meiosis/oogenesis-related.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":12},{"id":"GO:0046785","count":12},{"id":"GO:0021678","count":12},{"id":"GO:0021993","count":12},{"id":"GO:0070544","count":12}]},{"hash":"2192792580117895272","title":"Muscle contraction regulation and sarcomere organization","description":"The GO terms cluster around muscle function\u2014regulation and execution of contraction (including cardiac and smooth muscle), sarcomere organization, and muscle filament sliding\u2014plus ventricular morphogenesis. This suggests proteins involved in the contractile machinery and its regulation across muscle types, with a minor transcription-related term reflecting gene-level control.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006942","count":2},{"id":"GO:0014883","count":2},{"id":"GO:0032972","count":2},{"id":"GO:0060048","count":2}]},{"hash":"1872912713681016710","title":"Metanephric nephron development","description":"The top GO terms are heavily centered on metanephric tubule morphogenesis and nephron development (proximal/distal tubules, ascending limb), pointing to kidney development as the core theme of this cluster. Several immune-related terms appear, but they seem secondary to the dominant nephron morphogenesis pattern.","confidence":"Medium","size":20,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":19},{"id":"GO:0072237","count":19},{"id":"GO:0036303","count":19},{"id":"GO:0072287","count":19},{"id":"GO:0002223","count":19}]},{"hash":"443016349956848117","title":"Embryonic morphogenesis and axis specification","description":"This cluster is characterized by GO terms tied to embryonic development across multiple tissues (placenta, somites, hindlimb, amygdala, heart outflow tract) and axis formation (dorsal/ventral, rostral/caudal). The presence of a transcription-related term (DNA-templated transcription) suggests regulatory roles. Despite no reported edges, the set appears to group developmental regulators driving morphogenesis and lineage specification.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001893","count":2},{"id":"GO:0032525","count":2},{"id":"GO:0003148","count":2},{"id":"GO:0035116","count":2},{"id":"GO:0006351","count":2}]},{"hash":"723071374055044927","title":"Embryonic Development and Organogenesis","description":"These proteins are linked to diverse developmental processes, including bone, lens, heart, foregut morphogenesis, gastrulation, uterus, and somite formation, all rooted in DNA-templated transcription and epigenetic regulation. The common theme is embryonic development and organogenesis across tissues.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0060348","count":4},{"id":"GO:0002051","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0007507","count":3}]},{"hash":"175737672488866213","title":"Cytokine-driven inflammation and host defense","description":"The top GO terms cluster around cytokine production (IL-6, IL-13, IL-23), inflammatory responses, granulocyte chemotaxis, and defense against fungi/viruses, indicating an inflammatory immune activation program. A couple of sensory terms exist but are outweighed by immune-related functions, suggesting the cluster reflects cytokine-mediated inflammation and host defense.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042048","count":1},{"id":"GO:0050907","count":1},{"id":"GO:0032747","count":1},{"id":"GO:1900017","count":1},{"id":"GO:0071621","count":1}]},{"hash":"900732744571233427","title":"TLR-NFkB Innate Immune Signaling","description":"The cluster is dominated by GO terms for lipopolysaccharide response, TLR6/7 signaling, and cytokine-mediated signaling, with involvement of non-canonical NF-kappaB regulation, pointing to innate immune and inflammatory signaling as the core function. The other terms (axon guidance, lymph vessel morphogenesis, myelination, VEGF signaling) may reflect developmental cross-talk or shared signaling pathways but do not outweigh the innate immune theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0042346","count":2},{"id":"GO:0034154","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0036303","count":2}]},{"hash":"577567763390311049","title":"Circadian and Hormone-Responsive Regulation","description":"The top GO terms cluster around circadian regulation of gene expression, hormonal signaling (glucocorticoid and thyroid hormone pathways), and cellular stress responses, with additional tissue development/regulation terms. This suggests a module that links circadian control with endocrine signaling and environmental/stress responses, rather than a single tissue-specific process.","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032922","count":9},{"id":"GO:2000074","count":9},{"id":"GO:0060713","count":9},{"id":"GO:2001016","count":9},{"id":"GO:1904017","count":9}]},{"hash":"1647233377397658784","title":"Embryonic Development and Organogenesis","description":"The cluster is dominated by GO terms related to development across multiple tissues (mesoderm formation, skeletal muscle, chondrocyte differentiation, thymus, placenta, thyroid gland development) and neural patterning, indicating a broad embryonic organogenesis theme rather than a single pathway. While there is also DNA replication and general signaling, the shared signal is diverse developmental processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071374","count":3},{"id":"GO:1901621","count":3},{"id":"GO:0001707","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0048538","count":3}]},{"hash":"1658866930347120497","title":"Rho-GTPase\u2013Regulated Neuronal Signaling and Plasticity","description":"This cluster centers on regulation of Rho and GTPase activity, neurotransmitter secretion, and long-term potentiation, indicating proteins involved in neuronal signaling and cytoskeletal remodeling underlying synaptic plasticity. While some terms touch on development (heart development, angiogenesis), the strongest shared function is neuronal signal transduction and actin dynamics related to plasticity.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0006469","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007507","count":4}]},{"hash":"105575164715000110","title":"Oxidative Stress Detoxification and Redox Homeostasis","description":"Most terms cluster around detoxification of reactive species and maintenance of cellular redox balance (oxidant detoxification, redox homeostasis, glutathione metabolism). Additional terms indicate stress responses to various challenges (toxic substances, ethanol, starvation, metal exposure) and related signaling (prostaglandin biosynthesis, insulin stimulus). Together, they imply a functional group centered on redox control and detox pathways.","confidence":"High","size":19,"edges":60,"triangles":112,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":7},{"id":"GO:0045454","count":6},{"id":"GO:0006749","count":6},{"id":"GO:0001516","count":6},{"id":"GO:0009636","count":5}]},{"hash":"1081990687444669229","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":15,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045010","count":3},{"id":"GO:0051639","count":3},{"id":"GO:0006458","count":2},{"id":"GO:0051259","count":2},{"id":"GO:0071630","count":2}]},{"hash":"505034991602688110","title":"Developmental Morphogenesis","description":"Most top GO terms describe developmental processes and morphogenesis across multiple tissues (heart, eye, hindlimb, placenta, prostate, gonad), indicating a general theme of organ formation and tissue differentiation rather than a single tissue-specific function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":13},{"id":"GO:0001890","count":13},{"id":"GO:2000288","count":13},{"id":"GO:0060527","count":13},{"id":"GO:0021986","count":13}]},{"hash":"1085145752378061063","title":"Embryonic organogenesis and transcriptional regulation","description":"This cluster is dominated by GO terms related to developmental morphogenesis across several organs (heart, eye, limb, habenula, placenta, prostate) and includes DNA-templated transcription, indicating transcriptional control during embryonic organ development. The diverse but developmentally cohesive terms best support a label emphasizing embryonic organogenesis with gene regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":9},{"id":"GO:0001890","count":9},{"id":"GO:2000288","count":9},{"id":"GO:0060527","count":9},{"id":"GO:0021986","count":9}]},{"hash":"837661526532458777","title":"Wnt and Hedgehog-driven embryonic morphogenesis","description":"The cluster is enriched for embryonic development and morphogenesis terms, notably Wnt signaling and Hedgehog (Smoothened) pathway regulation, plus organ morphogenesis events (foregut, hindlimb, prostate gland) and myotube/smooth muscle differentiation, suggesting a shared role in developmental signaling guiding tissue formation.","confidence":"High","size":19,"edges":28,"triangles":9,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0060743","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0048745","count":2},{"id":"GO:0014902","count":2}]},{"hash":"1283181173000292301","title":"Ubiquitin-Dependent Protein Turnover and Chromatin Regulation","description":"The top GO terms in this cluster point to ubiquitin-related processes (ubiquitin-dependent protein catabolic process, monoubiquitination, deubiquitination) and chromatin-related events (nucleosome assembly, histone ubiquitination), with aggresome assembly also reflecting protein quality control linked to ubiquitin pathways. A few terms touch on development, but the dominant signal is ubiquitin-mediated protein turnover and chromatin regulation, suggesting a cohesive theme around protein quality control and chromatin dynamics.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070842","count":1},{"id":"GO:0010216","count":1},{"id":"GO:0032088","count":1},{"id":"GO:0036353","count":1},{"id":"GO:0035520","count":1}]},{"hash":"592482110134226023","title":"Lipid Metabolism and Hormone Biosynthesis","description":"The top GO terms cluster around lipid-related biosynthetic pathways (very long-chain fatty acid biosynthesis, fatty acid elongation, phylloquinone turnover) and hormone-related synthesis (retinoic acid and testosterone biosynthesis), with supporting development signals such as lung development that align with retinoid signaling. While there are also more general terms (drug response, transcription regulation), the dominant theme is lipid metabolism linked to hormone biosynthesis and related development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":17},{"id":"GO:0031427","count":16},{"id":"GO:0042761","count":16},{"id":"GO:0030497","count":16},{"id":"GO:0042376","count":16}]},{"hash":"1986624827813049671","title":"Steroid and lipid hormone biosynthesis and metabolism","description":"The cluster is dominated by GO terms for steroid hormone biosynthesis (cortisol, testosterone, aldosterone, progesterone) and lipid mediators (prostaglandin), with vitamin D response linking to secosteroid metabolism and uterus development reflecting hormonal regulation. Some outliers (insecticide metabolic process, vancomycin biosynthetic process) suggest broader metabolic functions but do not outweigh the hormone/lipid-centric pattern. Overall, the common theme is coordinated steroid and lipid metabolism and hormone-related processes.","confidence":"Medium","size":19,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":10},{"id":"GO:0033280","count":7},{"id":"GO:0033072","count":6},{"id":"GO:0034651","count":6},{"id":"GO:0061370","count":6}]},{"hash":"421767753931226258","title":"Insect reproductive and behavioral regulation","description":"The top GO terms center on modulation of reproductive behaviors (female receptivity after mating; regulation of egg-laying behavior) and larval locomotion, with additional terms related to behavioral responses to temperature and sensory cues. This suggests the cluster groups proteins involved in controlling insect behavior, particularly reproductive timing and locomotion, potentially via GPCR signaling pathways. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045434","count":6},{"id":"GO:0048042","count":6},{"id":"GO:0002209","count":6},{"id":"GO:1901045","count":6},{"id":"GO:0008345","count":6}]},{"hash":"2078848596739436875","title":"Neuroendocrine signaling and sensory perception","description":"The terms show neural signaling and sensory perception (olfactory behavior, chemical stimulus detection, GABAergic interneuron migration) and endocrine/vascular regulation (insulin secretion, vasodilation). While some GO terms are metabolic (electron transport chain), the dominant theme is neuroendocrine signaling and sensory modulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050796","count":4},{"id":"GO:0050728","count":4},{"id":"GO:0042048","count":4},{"id":"GO:0050907","count":4},{"id":"GO:0031635","count":3}]},{"hash":"1774607546413617894","title":"Cytoskeleton remodeling and endocytosis","description":"The cluster shows a pattern of actin-related processes (Arp2/3-mediated nucleation, actin cortical patch localization) and membrane trafficking (endocytosis) along with cell polarity/shape regulation, pointing to a cohesive theme around cytoskeletal remodeling and vesicle trafficking. There are some outlier terms related to translation and phototropism that do not fit this core theme. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046944","count":1},{"id":"GO:0002949","count":1},{"id":"GO:0006450","count":1},{"id":"GO:0034314","count":1},{"id":"GO:0006897","count":1}]},{"hash":"35896815555409703","title":"Unknown","description":"The GO terms show a mix of vertebrate development (thalamus and prostate gland development, male sex differentiation, steroid hormone receptor complex assembly) alongside innate immune responses (type I interferon signaling, dsRNA response, innate immune response), with no clear, single functional theme binding the proteins; thus a coherent cluster label cannot be confidently assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0046661","count":3},{"id":"GO:0006463","count":3}]},{"hash":"1022595520969162584","title":"Muscle contraction regulation and sarcomere organization","description":"This cluster is dominated by GO terms for regulation and execution of muscle contraction (including striated, smooth, and cardiac muscle), sarcomere organization, and muscle filament sliding, suggesting a cohesive muscle contraction/structure module.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006942","count":2},{"id":"GO:0014883","count":2},{"id":"GO:0032972","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0030049","count":2}]},{"hash":"754951534870380902","title":"Translation Machinery and Ribosome Function","description":"The top GO terms are dominated by translation and ribosome-related processes (translation, translational initiation/termination, ribosome assembly, mitochondrial translation, selenocysteine incorporation), indicating a cluster of proteins involved in protein synthesis machinery. Some unrelated terms (response to antibiotic, viral replication) appear as outliers but do not define the core theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0046677","count":3},{"id":"GO:0006415","count":2},{"id":"GO:0006353","count":2},{"id":"GO:0042255","count":2}]},{"hash":"1413690353365188452","title":"Cell signaling and cytoskeletal dynamics","description":"The top GO terms include cell signaling pathways (ephrin receptor signaling, T cell receptor signaling), cytoskeleton-related processes (actin cytoskeleton reorganization, maintenance of cell polarity, response to mechanical stimulus), and trafficking and division processes (COPII vesicle budding, cell division). This mix suggests a cluster of proteins involved in coordinating signaling with cytoskeletal remodeling and vesicular transport, rather than a single precise process.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0048013","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0007612","count":2}]},{"hash":"14499387105064342","title":"GTPase-mediated developmental differentiation","description":"Top GO terms indicate both small GTPase\u2013mediated signaling and broad developmental processes across tissues, including trophoblast giant cell differentiation, mammary gland development, cartilage development, endocrine system development, axonogenesis, forebrain proliferation, mesenchymal proliferation, and smooth muscle differentiation. This pattern suggests a cluster of proteins that regulate development primarily through GTPase signaling pathways, coordinating proliferation and tissue-specific differentiation in multiple lineages. The link is functional, centered on GTPase-driven signaling as a common mechanism.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0033601","count":2},{"id":"GO:0051150","count":1}]},{"hash":"2181714276853101884","title":"Cerebellar Cortex Development and Bergmann Glia Differentiation","description":"This cluster is dominated by terms related to cerebellar development, notably cerebellar cortex formation and Bergmann glial cell differentiation, suggesting a shared role in cerebellar maturation. Supporting terms on axon regeneration and ERK signaling modulation indicate broader neural development and signaling regulation, with transcriptional control reflecting gene-expression programs. Some outliers (immune signaling terms) are present but do not override the cerebellar-development theme.","confidence":"Medium","size":19,"edges":24,"triangles":6,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0050852","count":7},{"id":"GO:0070373","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0048679","count":5}]},{"hash":"1128040689855657851","title":"Immune signaling and cytoskeletal remodeling","description":"The top GO terms point to immune cell signaling (dendritic cell differentiation, B cell receptor signaling, neutrophil chemotaxis) alongside actin cytoskeleton dynamics (actin filament branching, cytoskeleton reorganization) and vesicle transport (ER to Golgi). This combination suggests proteins involved in immune activation coupled with cytoskeletal remodeling and secretory trafficking, with some association to osteoclast development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0030593","count":2},{"id":"GO:0035900","count":2},{"id":"GO:0006888","count":2}]},{"hash":"1333710088974518021","title":"Prostate Gland Development and Apoptotic Signaling","description":"The terms include epithelial differentiation and growth in the prostate gland, plus apoptotic processes and recognition of apoptotic cells, suggesting a role in prostate tissue homeostasis. Lipid signaling is indicated by sphingolipid metabolism and aminophospholipid transport, and GPCR signaling may reflect regulatory signaling in this context. Overall, the cluster seems to tie prostate development with regulated cell death and related lipid signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903206","count":2},{"id":"GO:0060742","count":2},{"id":"GO:0060736","count":2},{"id":"GO:0007193","count":2},{"id":"GO:0006665","count":2}]},{"hash":"1844002824792504209","title":"Unknown","description":"The top GO terms span diverse themes (sex determination and gonad development, general signaling via IGF, PKC, and Akt, transcription by Pol III, Schwann cell differentiation, UV response, and immune-related processes) with no single cohesive function tying the proteins together, and the network has no edges, suggesting a heterogeneous cluster. Therefore Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035225","count":1},{"id":"GO:0070141","count":1},{"id":"GO:0048009","count":1},{"id":"GO:0060267","count":1},{"id":"GO:0045945","count":1}]},{"hash":"276108354033774845","title":"HGF/MET signaling and angiogenesis","description":"The cluster is anchored by GO terms for hepatocyte growth factor receptor signaling and cellular response to HGF stimulus, with supporting terms related to angiogenesis and vascular development such as cell migration in sprouting angiogenesis and retina vasculature morphogenesis. The presence of regulatory terms (negative regulation of signaling, endocytosis, and protein binding) further supports a theme of HGF/MET signaling control underlying angiogenic processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048012","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0032091","count":1},{"id":"GO:0048259","count":1},{"id":"GO:1900116","count":1}]},{"hash":"1246650734071422617","title":"Broad-spectrum membrane transporters","description":"Based on the top GO terms, most entries are associated with transmembrane transport of diverse substrates (nitrates, sugars like arabinose and galactose, vitamin transport, sodium ions, xenobiotics, and related metabolites). This points to a cluster of membrane transporter proteins with broad substrate specificity rather than a single, narrow function. The apoptotic term is present but not central to the main theme of transport; the dominant signal is membrane transport activity across multiple substrates.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0048671","count":2},{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2}]},{"hash":"852873297528351882","title":"Oocyte Meiosis and Spindle Assembly","description":"The top GO terms concentrate on oocyte maturation, spindle assembly in female meiosis I, and microtubule dynamics, with supporting links to SCF-proteasomal degradation and cell-cycle regulation. Some neural development terms seem incidental, but the dominant signal is meiosis/oocyte maturation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":4},{"id":"GO:0006516","count":3},{"id":"GO:0046785","count":3},{"id":"GO:0021678","count":3},{"id":"GO:0021993","count":3}]},{"hash":"1369464503183752647","title":"Glycogen Metabolism Regulation","description":"The top GO terms are dominated by glycogen metabolism and its regulation (glycogen metabolic process; regulation of glycogen catabolic process; positive regulation of glycogen biosynthetic process; positive regulation of glycogen synthase activity). This suggests the cluster centers on enzymes or regulators of glycogen synthesis and breakdown. A few other terms (microtubule polymerization, brain development, glycoprotein catabolic process) may reflect pleiotropy or annotation noise rather than a single cohesive function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005977","count":1},{"id":"GO:0005981","count":1},{"id":"GO:0045725","count":1},{"id":"GO:2000467","count":1},{"id":"GO:0006516","count":1}]},{"hash":"2176011884702099154","title":"Sperm flagellum axoneme assembly and motility","description":"The GO terms point strongly to cilia/axonemes and sperm flagellum function, including sperm axoneme assembly, cilium movement, and motility. The presence of tubulin modifications like polyglutamylation and polyglycylation further supports a flagellar/ciliary role, as these PTMs are known to regulate axonemal microtubules and dynein activity. Together, these terms suggest proteins cluster around sperm flagellum assembly and motility rather than unrelated processes.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051013","count":1},{"id":"GO:0003351","count":1},{"id":"GO:0018095","count":1},{"id":"GO:0018094","count":1},{"id":"GO:0003353","count":1}]},{"hash":"1972079272276810144","title":"Unknown","description":"There are no GO terms or interactions provided for this cluster (Top Terms is empty and Max Degree is 0), so there is no clear shared function to label; the mention of \"4 proteins re-added by ReCIPE\" does not establish a common biological role.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"676583580087085991","title":"Microtubule-Driven Cell Division and Nuclear Migration","description":"The terms cluster around microtubule-based processes including spindle assembly, nuclear movement along microtubules, and DNA replication, suggesting a unit centered on cell division and cytoskeletal organization. Some outliers (zonula adherens maintenance, stress granule disassembly, chloroplast movement) may reflect broader cytoskeletal coordination across contexts, but the core theme remains microtubule-driven cellular dynamics.","confidence":"Medium","size":18,"edges":62,"triangles":110,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":8},{"id":"GO:0006260","count":5},{"id":"GO:0031535","count":5},{"id":"GO:0045218","count":5},{"id":"GO:0035617","count":5}]},{"hash":"247897998575434219","title":"Neural sensory signaling and auditory processing","description":"These terms collectively point to neural signaling and sensory processing, with emphasis on serotonergic/dopaminergic signaling, synaptic transmission, and auditory-related development (cochlea). Ion transport terms support neuronal excitability, aligning with neural circuit function in sensory perception, especially hearing.","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0007210","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0043200","count":1},{"id":"GO:0050893","count":1}]},{"hash":"2023549020437187209","title":"GPCR-Mediated cAMP and PLC Signaling","description":"The cluster centers on GPCR signaling pathways that activate adenylyl cyclase and phospholipase C (dopamine/adrenergic signaling) with downstream small GTPase activity, consistent with phototransduction and heart development terms.","confidence":"High","size":18,"edges":29,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":6},{"id":"GO:0010513","count":6},{"id":"GO:0071880","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0007603","count":6}]},{"hash":"2239313358410902928","title":"Neural signaling and cytoskeletal remodeling","description":"The cluster\u2019s terms predominantly relate to neural processes (sensory perception of sound, locomotory and exploration behaviors, GABAergic synaptic transmission, radial glial differentiation) and to actin cytoskeleton dynamics (actin organization, Rho/GTPase signaling). These together point to neural signaling with active cytoskeletal remodeling that supports neuronal movement and synaptic function. Some terms like acrosome reaction also involve cytoskeletal changes but do not outweigh the neural-centric theme. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0035640","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0007340","count":2}]},{"hash":"386127452233660651","title":"Pain and thermosensory neural signaling","description":"This cluster is dominated by GO terms for sensory perception of pain, cellular response to temperature stimulus, regulation of membrane potential, and positive regulation of GTPase activity, all hallmark features of neural signaling and nociception/thermosensation. Additional terms like retina and heart development suggest broader roles for signaling pathways in sensory and cardiovascular/visual tissue development, but the core theme centers on neural sensory processing and signaling.","confidence":"Medium","size":18,"edges":125,"triangles":460,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0043547","count":9},{"id":"GO:0042391","count":9},{"id":"GO:0071502","count":9},{"id":"GO:0002024","count":9}]},{"hash":"989147406284218794","title":"Embryonic development and organ morphogenesis","description":"Top terms cluster around organ-specific morphogenesis during development (heart outflow tract, hindlimb, placenta, male gonads, prostate, habenula). The recurring DNA-templated transcription term also points to transcriptional regulation in development. This suggests proteins in this cluster participate in developmental regulation across multiple tissues rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":5},{"id":"GO:0035116","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0001890","count":5}]},{"hash":"91259630767276711","title":"Neurodevelopmental Gene Regulation","description":"The cluster is dominated by neural development terms such as subpallium neuron fate commitment, cerebral cortex GABAergic interneuron differentiation, spinal cord motor neuron and oligodendrocyte fate specification, along with transcription-related terms (RNA polymerase II transcription, DNA-templated transcription) and circadian regulation of gene expression, suggesting a cohesive set of transcriptional regulators governing neural differentiation. There are a couple of outlier terms (endocrine pancreas development, male gonad development), but the overall theme centers on neural development and transcriptional control.","confidence":"High","size":18,"edges":150,"triangles":769,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":7},{"id":"GO:0006366","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0008584","count":6},{"id":"GO:0032922","count":5}]},{"hash":"417408591984631990","title":"Organelle Gene Expression and RNA Processing","description":"The cluster shows enrichment for translation and RNA processing terms (cytoplasmic translation, translation, RNA splicing) together with organelle-specific expression controls (termination of mitochondrial transcription, chloroplast organization), suggesting a cohesive theme around gene expression regulation across organelles, with some associated metabolic terms.","confidence":"Medium","size":18,"edges":137,"triangles":610,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0070584","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0051591","count":2},{"id":"GO:0006099","count":2}]},{"hash":"901631316162844911","title":"Embryonic organogenesis and morphogenesis","description":"The set of terms centers on embryonic development across multiple tissues\u2014heart (outflow tract morphogenesis, cardiac muscle proliferation), eye, hindlimb, placenta, gonads, prostate, and habenula\u2014indicating a general theme of organogenesis rather than a single pathway.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":7},{"id":"GO:0003148","count":6},{"id":"GO:2000288","count":6},{"id":"GO:0021986","count":6},{"id":"GO:0048048","count":6}]},{"hash":"783144948781357908","title":"Developmental transcription and morphogenesis regulators","description":"The terms converge on transcriptional control during development and tissue morphogenesis (DNA-templated transcription, circadian regulation, miRNA transcription regulation) and span multiple developmental processes (embryonic development, eye and heart morphogenesis, ovarian follicle growth, adipose and prostate development), suggesting a cluster of regulators coordinating developmental gene expression and organ formation.","confidence":"High","size":18,"edges":13,"triangles":12,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:1902894","count":8},{"id":"GO:0060528","count":7},{"id":"GO:0032922","count":7},{"id":"GO:1904179","count":7}]},{"hash":"1365372057103479606","title":"Embryonic Organogenesis and Gene Regulation","description":"GO terms indicate morphogenesis across multiple organs (heart, eye, placenta, habenula, prostate) along with transcriptional regulation, suggesting the cluster comprises developmental proteins with gene-expression control roles.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":10},{"id":"GO:0001890","count":10},{"id":"GO:2000288","count":10},{"id":"GO:0060527","count":10},{"id":"GO:0021986","count":10}]},{"hash":"853480123320426469","title":"Embryonic development and organ morphogenesis","description":"The top GO terms cluster around morphogenesis and development across multiple organs (heart, eye, hindlimb, placenta, cerebellum, prostate, habenula). This suggests a general developmental program rather than a tissue-specific pathway, so \u201cEmbryonic development and organ morphogenesis\u201d is an appropriate label.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":16},{"id":"GO:0008584","count":16},{"id":"GO:0001890","count":16},{"id":"GO:2000288","count":16},{"id":"GO:0060527","count":16}]},{"hash":"2170775521033451740","title":"Multisystem Developmental Regulation","description":"This cluster centers on developmental processes across multiple tissues (retina, habenula, placenta, osteoblasts, prostate) and includes DNA-templated transcription, suggesting genes involved in broad developmental programs rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0045872","count":8},{"id":"GO:2000288","count":8},{"id":"GO:0021986","count":8}]},{"hash":"1955925721359020338","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0010587","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0030260","count":2}]},{"hash":"1188418734460912820","title":"Unknown","description":"The GO terms are scattered across sumoylation (autosumoylation and regulation of sumoylation), DNA damage/meiotic processes, multiple developmental pathways (osteoblast differentiation, heart morphogenesis, vitellogenesis), and membrane potential regulation, with no single cohesive theme linking all members. This breadth suggests no clear, unifying cluster function.","confidence":"","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990466","count":2},{"id":"GO:0033235","count":2},{"id":"GO:1904290","count":2},{"id":"GO:0045667","count":2},{"id":"GO:0010804","count":2}]},{"hash":"847355329397432278","title":"Stem cell maintenance and germline development","description":"This cluster is dominated by GO terms related to stem cell maintenance and germline processes, including intestinal stem cell homeostasis, stem cell population maintenance, spermatid differentiation, and male germ-line cyst formation, with BMP signaling reinforcing developmental niche functions. Some terms (autophagy, cell cycle, immune signaling, behavior) are broader or incidental, but the core pattern supports a stem cell/germline development theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070236","count":1},{"id":"GO:0008101","count":1},{"id":"GO:0048642","count":1},{"id":"GO:0036335","count":1},{"id":"GO:0001662","count":1}]},{"hash":"925879083274768572","title":"Dopaminergic and GABAergic neurotransmission regulation","description":"The topGO terms strongly point to neural signaling, with regulation of dopamine secretion and GABAergic synaptic transmission, plus enteric nervous system development, suggesting a focus on neural communication and development. A few translation-related terms appear, possibly reflecting neuron-specific protein synthesis, but the core theme is neural signaling regulation.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034517","count":2},{"id":"GO:0014059","count":2},{"id":"GO:0032228","count":2},{"id":"GO:0031664","count":2},{"id":"GO:0048484","count":2}]},{"hash":"1762835269240042162","title":"ER-Golgi Vesicle Trafficking and Protein Transport","description":"The top GO terms point strongly to the secretory pathway, with COPII vesicle budding and ER-to-Golgi transport as dominant categories. Additional terms indicate broad protein transport and processing roles, along with developmental and cell growth signals (kidney development, Hedgehog signaling, ribosome biogenesis, and mitotic spindle assembly). Together, these suggest a cluster centered on intracellular trafficking through the secretory pathway, plus related growth/division processes. ","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090114","count":6},{"id":"GO:0006888","count":5},{"id":"GO:0000060","count":5},{"id":"GO:0071806","count":5},{"id":"GO:0051291","count":5}]},{"hash":"968464368202239743","title":"Cartilage and bone matrix organization","description":"This cluster is driven by GO terms tied to skeletal development and extracellular matrix (ECM) remodeling, especially cartilage development, endochondral ossification, collagen fibril organization, and collagen catabolic processes, along with integrin biosynthesis. Together these point to assembly and remodeling of the ECM in skeletal tissues. Other terms like podocyte development or lipoprotein clearance may reflect broader ECM-related roles, but the dominant signal is skeletal ECM organization.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3},{"id":"GO:0045112","count":3},{"id":"GO:0001958","count":3}]},{"hash":"1191500130819131454","title":"Membrane Transporters and Metabolic Regulation","description":"Dominated by transmembrane transport terms across metals, vitamins, xenobiotics, and related metabolic regulation terms (fatty acid beta-oxidation). Some terms are development or secretion related, but the unifying theme is membrane transport and substrate handling, with metabolism as a secondary thread.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":2},{"id":"GO:0051966","count":2},{"id":"GO:0001707","count":2},{"id":"GO:0070574","count":2},{"id":"GO:0035461","count":1}]},{"hash":"259420880726778833","title":"Plant cell wall assembly and plasmodesmata regulation","description":"The top GO terms cluster around plant-type cell wall organization, cellulose biosynthesis regulation, and plasmodesma organization, with supporting terms for lignin metabolism and related carbohydrate processes, indicating a module focused on plant cell wall construction/modification and intercellular transport structures. Some detoxification and secondary metabolism terms are present but do not define the primary function of the cluster.","confidence":"High","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0009831","count":2},{"id":"GO:2001009","count":2},{"id":"GO:0009663","count":2},{"id":"GO:0098869","count":2}]},{"hash":"510928681043512230","title":"Unknown","description":"The GO terms are spread across mitochondrial translation, fatty acid metabolism, and various biosynthetic processes (including PHB and antibiotic biosynthesis) as well as ER organization and drug response. The set mixes organelle-specific functions with bacterial pathways and stress responses, suggesting no single cohesive function tying all proteins together. Therefore a concise, meaningful label cannot be inferred with confidence.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":4},{"id":"GO:0042619","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0007029","count":3}]},{"hash":"904927125917939121","title":"Rab-mediated ER-Golgi vesicle trafficking","description":"The cluster is dominated by GO terms for ER-to-Golgi transport and COPII-coated vesicle budding, complemented by Rab protein signal transduction, pointing to Rab-regulated vesicle trafficking in the secretory pathway. While there are neural development and cell-cycle terms present, they are likely context-specific annotations rather than core functions of the cluster.","confidence":"High","size":18,"edges":19,"triangles":1,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0090114","count":4},{"id":"GO:0010628","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0055091","count":3}]},{"hash":"2205962998165739156","title":"Rho GTPase signaling and actin remodeling","description":"This cluster centers on regulation of Rho protein signal transduction and positive regulation of GTPase activity, with multiple terms pointing to actin cytoskeleton organization (actin filament bundle assembly). Together they suggest a cohesive theme of Rho-mediated cytoskeletal dynamics that also interfaces with broader signaling processes (including immune signaling and apoptosis). Confidence is High.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0043547","count":2},{"id":"GO:1900740","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0051017","count":2}]},{"hash":"903688066915253258","title":"ER stress and vesicle trafficking during viral infection","description":"The GO terms cluster around endoplasmic reticulum (ER)\u2013associated processes: COPII vesicle budding, ER localization, ER unfolded protein response, and ER calcium homeostasis, plus Rab signaling and phosphatidylinositol dephosphorylation related to membrane trafficking. The presence of host\u2013mediated activation/suppression of viral genome replication further ties these ER/trafficking processes to host\u2013virus interactions that can influence viral replication. Together, these points support a cohesive theme of ER stress responses and vesicle trafficking in the context of viral infection.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044829","count":3},{"id":"GO:0090114","count":2},{"id":"GO:0006987","count":2},{"id":"GO:0044828","count":2},{"id":"GO:0006874","count":2}]},{"hash":"1275293024783253462","title":"Cerebellar Development and Glial Differentiation","description":"The cluster is dominated by cerebellum-related terms, notably cerebellar cortex formation and Bergmann glial cell differentiation, indicating a focus on cerebellar development. Additional neural differentiation and signaling terms (axon regeneration, insulin receptor signaling) support a broader neural development context, but the cerebellar-specific terms are the strongest signal for labeling this cluster. ","confidence":"Medium","size":18,"edges":34,"triangles":9,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":16},{"id":"GO:0008285","count":16},{"id":"GO:0021697","count":16},{"id":"GO:0008286","count":16},{"id":"GO:0048679","count":16}]},{"hash":"257335676430252573","title":"Unknown","description":"The top GO terms span development (neural tube closure), apoptosis, cilium assembly, cellular stress responses, cell cycle-related catabolic processes, ubiquitin-proteasome/ERAD pathways, signaling regulation (GTPase activity, TGF-beta), and chromatin modification. There is no single coherent function uniting these terms for this cluster, suggesting the proteins may participate in diverse, context-dependent roles rather than one shared pathway. Therefore, an Unknown label is most appropriate.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":2},{"id":"GO:0006915","count":2},{"id":"GO:1905515","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0031145","count":2}]},{"hash":"2070236281203895229","title":"Oxidative Stress Response and Nuclear Transport Regulation","description":"The cluster\u2019s top terms cluster around detoxification and response to hydrogen peroxide, apoptotic processes, and nuclear regulation (DNA-templated transcription and negative regulation of protein export from the nucleus), with supporting hints from cytochrome complex assembly and some developmental functions (lens transparency, heart development). This suggests a cohesive theme of managing oxidative stress while coordinating nuclear trafficking and transcription, potentially impacting development. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0046826","count":3},{"id":"GO:0017004","count":3},{"id":"GO:0036438","count":2}]},{"hash":"2211668860553143747","title":"Neuronal actin remodeling","description":"The top GO terms converge on actin cytoskeleton dynamics in neurons: Arp2/3 complex\u2013mediated nucleation, lamellipodium assembly, and regulation of barbed-end actin capping, plus substrate adhesion\u2013dependent spreading. This points to actin remodeling processes that drive neurite outgrowth and synaptic formation. Other terms about neuronal development and neural environment/transport support the neural context but are less central, making actin regulation in neurons the primary theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":1},{"id":"GO:0034314","count":1},{"id":"GO:0010592","count":1},{"id":"GO:2000814","count":1},{"id":"GO:1902476","count":1}]},{"hash":"386819559761958555","title":"Polyadenylation-Dependent RNA Decay","description":"Most GO terms cluster around RNA metabolism tied to polyadenylation-dependent decay, including nuclear rRNA/mRNA decay and snoRNA polyadenylation, plus mitochondrial mRNA polyadenylation and tRNA stabilization. This suggests proteins in the cluster function in RNA turnover and maturation via poly(A) pathways, with a few incidental terms related to signaling or reproduction.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071035","count":2},{"id":"GO:0071039","count":2},{"id":"GO:1990603","count":1},{"id":"GO:0071050","count":1},{"id":"GO:0031664","count":1}]},{"hash":"1049982735363143690","title":"Meiosis I spindle assembly and ubiquitin-proteasome regulation","description":"The top GO terms are dominated by oocyte maturation, spindle assembly in female meiosis I, SCF-dependent ubiquitin-protein ligase activity, and proteasomal protein catabolic processes, all pointing to regulation of meiosis and cell-cycle progression with an emphasis on proteolysis and microtubule dynamics. While a couple of terms relate to broader neural development, the strongest signals center on meiosis I spindle formation and ubiquitin-mediated proteolysis, suggesting these proteins function together in oocyte maturation and meiotic control.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":3},{"id":"GO:0051436","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2}]},{"hash":"1003695592084909344","title":"Embryonic and Organ Development","description":"Top GO terms largely reflect developmental programs across organs (skeletal muscle development, third ventricle development, neural tube closure initiation, ureteric bud branching). Some terms point to general cellular processes (microtubule polymerization, glycoprotein catabolic process, negative regulation of cell proliferation), likely underpinning those developmental events. Overall, the proteins appear to cluster around embryonic and organ development themes rather than a single specific pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0021678","count":2}]},{"hash":"1748647930261552355","title":"Transcription Regulation and Receptor Clustering","description":"The Top Terms show a strong emphasis on transcriptional control (positive/negative regulation of transcription by RNA polymerase II, DNA-templated transcription) and transcription itself, with additional signals of receptor clustering (NMDA glutamate receptor clustering) and epithelial polarity. Although there are some outliers (antibiotic biosynthesis, face morphogenesis), the recurring theme centers on gene expression regulation and associated receptor organization, justifying this label as representative of the cluster\u2019s core function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:1901766","count":1},{"id":"GO:0017000","count":1},{"id":"GO:0045944","count":1},{"id":"GO:0031342","count":1}]},{"hash":"354534030527779618","title":"Endothelial signaling and barrier regulation","description":"This cluster features terms tied to membrane and receptor signaling (receptor internalization, receptor guanylyl cyclase signaling, intracellular signal transduction) and to endothelial barrier maintenance (establishment of endothelial intestinal barrier), complemented by cytoskeletal dynamics (astral microtubule organization, negative regulation of stress fiber assembly) and related regulatory processes (tyrosine phosphorylation of STAT, PARylation). Together these suggest a theme of signaling pathways that control endothelial barrier function and cytoskeletal organization, making a coherent, if broad, functional label appropriate.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0070212","count":2},{"id":"GO:0030953","count":2},{"id":"GO:0051497","count":2}]},{"hash":"446702608985786924","title":"Olfactory cues modulate mating and egg-laying behavior","description":"The cluster is dominated by GO terms for detection of chemical stimuli and olfactory behavior, with several terms about regulation of female receptivity, mating, egg-laying, and related larval movement, suggesting proteins involved in olfactory sensing and consequent reproductive/locomotor behaviors. A few unrelated terms (dermatan sulfate and ureteric bud formation) appear incidental. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":7},{"id":"GO:0042048","count":6},{"id":"GO:0045434","count":3},{"id":"GO:0048042","count":3},{"id":"GO:0002209","count":3}]},{"hash":"237854940832667971","title":"Cytoskeletal transport and secretory pathway proteins","description":"The cluster is dominated by terms related to microtubule-based movement and the secretory pathway, including mitotic spindle assembly, COPII vesicle budding, and ER-to-Golgi and Golgi-to-ER transport. While pigmentation and locomotion/development terms appear, the shared theme across the terms is cytoskeleton-driven transport and vesicle trafficking. Medium","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0051260","count":2}]},{"hash":"914148815737366523","title":"Synaptic Plasticity and Actin Remodeling","description":"The cluster shows terms centered on neuronal signaling and plasticity (long-term synaptic depression, pain perception) alongside strong signals of actin cytoskeleton dynamics (actin filament organization, Arp2/3-mediated nucleation regulation, membrane tubulation). This suggests a cohesive theme where synaptic changes are supported by cytoskeletal remodeling and membrane remodeling processes. Some terms such as viral mRNA export and protein homooligomerization appear more general, but the dominant pattern aligns with neuronal plasticity and cytoskeletal dynamics.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010467","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0050966","count":2},{"id":"GO:0046784","count":2}]},{"hash":"956291770214337572","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0006458","count":1},{"id":"GO:0055122","count":1},{"id":"GO:0051259","count":1}]},{"hash":"395001616474582305","title":"ECM adhesion and integrin signaling","description":"These proteins cluster around extracellular matrix interactions, cell-matrix adhesion, and integrin-mediated signaling, supported by terms like integrin-mediated signaling, calcium-independent cell-matrix adhesion, substrate-dependent cell migration, and negative regulation of ECM assembly. Additional terms such as dendrite regeneration, blood coagulation, and T cell activation suggest broader signaling roles linked to tissue remodeling and immune interactions, while proteasome assembly points to protein turnover accompanying these processes. The chlorophyll biosynthetic process appears unrelated and likely an annotation artifact. Overall, the dominant theme is ECM adhesion and integrin-driven signaling guiding migration and remodeling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031104","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0007229","count":3},{"id":"GO:0043248","count":3},{"id":"GO:0006929","count":3}]},{"hash":"937983803079411209","title":"Synaptic receptor clustering and spine development","description":"Several top GO terms are directly tied to neuronal synapses, notably NMDA receptor clustering, AMPA receptor clustering, and positive regulation of dendritic spine development. Together these point to proteins functioning in synapse organization and maturation. While there are some lipid/metabolism and vascular-related terms, the dominant signal is postsynaptic receptor clustering and spine formation, which justifies the label.","confidence":"High","size":17,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006869","count":2},{"id":"GO:0010544","count":1},{"id":"GO:0097114","count":1},{"id":"GO:0060999","count":1},{"id":"GO:0010873","count":1}]},{"hash":"1980318251860878010","title":"RNA processing and ribosome biogenesis","description":"This cluster is centered on RNA processing and ribosome biology, with strong signals for rRNA maturation (SSU/5.8S/LSU) and ribosomal large subunit biogenesis, plus spliceosome-mediated mRNA splicing and translation initiation. A minor, related signal includes regulatory ncRNA-mediated gene silencing and protein ubiquitination, suggesting coordinated post-transcriptional and translational regulation.","confidence":"High","size":17,"edges":5,"triangles":0,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0000398","count":3}]},{"hash":"1369153832452017195","title":"Cardiac and Neuronal GPCR Signaling","description":"The cluster shows strong representation of heart development and multiple GPCR signaling pathways (adrenergic/dopaminergic receptor signaling, cAMP signaling, phospholipase C activation), along with regulation of calcium-dependent exocytosis and GTPase activity, indicating a cohesive group of proteins involved in GPCR-mediated signal transduction affecting cardiac and neural development. The phototransduction term is likely a shared signaling component rather than a defining function, but does not override the dominant GPCR/development theme.","confidence":"High","size":17,"edges":30,"triangles":30,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":15},{"id":"GO:0043950","count":12},{"id":"GO:0010513","count":12},{"id":"GO:0071880","count":12},{"id":"GO:0043547","count":12}]},{"hash":"1012765867224798263","title":"RNA splicing and mRNA processing","description":"This cluster shows strong enrichment for spliceosome-mediated mRNA splicing and several post-transcriptional processes, including mRNA export, modification, stability regulation, and alternative splicing control, plus translation reinitiation, indicating a cohesive role in RNA processing and gene expression regulation at the post-transcriptional level.","confidence":"High","size":17,"edges":92,"triangles":250,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":7},{"id":"GO:0010610","count":6},{"id":"GO:1901407","count":6},{"id":"GO:1902625","count":5},{"id":"GO:0002188","count":5}]},{"hash":"1205224293927242027","title":"mRNA processing and translation initiation regulation","description":"The top GO terms cluster around post-transcriptional control: translation initiation and reinitiation (including IRES-dependent initiation) and preinitiation complex formation, plus regulation of translational initiation and stress-related mRNA stability. There are also spliceosome-related mRNA processing terms and regulatory ncRNA-mediated silencing, suggesting a cohesive module of RNA maturation and translation control. The set points to a core function in coordinating how mRNAs are processed and translated, especially under stress or viral-like contexts.","confidence":"High","size":17,"edges":31,"triangles":35,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0010610","count":4},{"id":"GO:0075522","count":4},{"id":"GO:0006446","count":4},{"id":"GO:0006378","count":4}]},{"hash":"2196001414331405114","title":"GTPase-regulated vesicle trafficking","description":"The cluster centers on GO terms related to regulation of GTPase activity, phosphatidylinositol dephosphorylation, and the multivesicular body sorting pathway, pointing to small GTPase\u2013driven membrane trafficking and endosomal sorting as the core function. Supporting terms related to cytoskeletal/muscle homeostasis may reflect broader signaling or structural roles, but the dominant theme is trafficking and GTPase signaling.","confidence":"Medium","size":17,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":1},{"id":"GO:0046716","count":1},{"id":"GO:0046856","count":1},{"id":"GO:0071985","count":1},{"id":"GO:0046855","count":1}]},{"hash":"1983585150827693235","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":107,"triangles":433,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":13},{"id":"GO:0048026","count":13},{"id":"GO:0019079","count":9},{"id":"GO:0006260","count":9},{"id":"GO:0000472","count":8}]},{"hash":"1278361488425116275","title":"RNA Processing and Antiviral Defense","description":"The top GO terms cluster around RNA biology\u2014miRNA-mediated gene silencing, mRNA stability under stress, and ribosomal subunit biogenesis\u2014along with terms related to viral RNA genome interactions, suggesting a shared theme of RNA processing, quality control, and host antiviral responses. Some terms (e.g., brain development, lipoprotein biosynthesis, base-excision repair) are less cohesive with the core theme, but the dominant signal centers on RNA metabolism and antiviral processes.","confidence":"Medium","size":17,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000637","count":3},{"id":"GO:0045716","count":2},{"id":"GO:0010323","count":2},{"id":"GO:0061481","count":2},{"id":"GO:0022013","count":2}]},{"hash":"717480933721148991","title":"Mitochondrial energy metabolism and nucleotide biosynthesis","description":"Top GO terms include acyl-CoA metabolic process, GMP/GTP biosynthesis, and respiratory chain complex IV assembly, suggesting mitochondrial energy production and nucleotide synthesis as the core theme of this cluster. Some terms (retina development, lymphocyte proliferation) appear peripheral to the main signal, but do not dominate the functional pattern.","confidence":"Medium","size":17,"edges":18,"triangles":4,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006637","count":3},{"id":"GO:0060041","count":2},{"id":"GO:0006144","count":2},{"id":"GO:0046651","count":2},{"id":"GO:0006183","count":2}]},{"hash":"415965846592956527","title":"Embryonic Organogenesis","description":"The GO terms cluster around embryonic development and organ morphogenesis, including heart development, eye morphogenesis, outflow tract morphogenesis, placenta development, habenula development, and prostate gland morphogenesis, plus in utero embryonic development. Regulatory terms like transcription by RNA polymerase II and negative regulation of transcription by RNA polymerase II suggest a coordinated gene-expression program during development. Together, these indicate a theme of embryogenesis and tissue/organ formation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":7},{"id":"GO:0001701","count":6},{"id":"GO:0006366","count":6},{"id":"GO:0003148","count":6},{"id":"GO:0000122","count":6}]},{"hash":"1957996324961086730","title":"Unknown","description":"The top terms cover a mix of DNA-templated transcription, redox homeostasis, histone methylation, transcriptional regulation, antigen biosynthesis, glycinergic synaptic transmission, and development. The set lacks a single coherent functional theme, and several terms are obsolete, making it difficult to assign a specific, representative function to the cluster.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0051567","count":2},{"id":"GO:0036129","count":1},{"id":"GO:1902376","count":1}]},{"hash":"1486525004867188908","title":"Embryonic organ and tissue development","description":"The Top Terms point to a broad set of morphogenesis and development processes across diverse tissues (heart, eye, hindlimb, placenta, habenula, etc.), with some transcriptional activity; the shared theme is developmental organogenesis rather than a single specific pathway, so the label captures the overarching function of the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":12},{"id":"GO:0001890","count":12},{"id":"GO:2000288","count":12},{"id":"GO:0060527","count":12},{"id":"GO:0021986","count":12}]},{"hash":"760156684419570139","title":"Ubiquitin-Dependent Degradation and ERAD","description":"The top terms emphasize ubiquitin-dependent proteolysis (including K48- and K6-linked ubiquitination) and ER-associated degradation (ERAD), plus SRP-dependent cotranslational targeting to membranes, indicating a cohesive theme of ubiquitin-mediated protein quality control and targeting to the ER. Some other terms (V(D)J recombination, TNF signaling) may reflect broader ubiquitin-related regulation but do not override the core pattern. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006614","count":2},{"id":"GO:0006616","count":2}]},{"hash":"114598218990088625","title":"Embryonic development and lineage differentiation","description":"Top GO terms indicate broad developmental processes across neural/glial lineages (amacrine cell differentiation, oligodendrocyte development, floor plate development, somitogenesis) and mesodermal derivatives (skeletal muscle differentiation, lung vasculature development), with transcription by RNA polymerase II and circadian regulation of gene expression shaping timing. This suggests a cohesive theme of embryonic tissue patterning and lineage specification across multiple lineages.","confidence":"High","size":17,"edges":51,"triangles":43,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0032922","count":5},{"id":"GO:0043433","count":4},{"id":"GO:0071285","count":4},{"id":"GO:0060426","count":4}]},{"hash":"529381707543529","title":"Embryonic Development and Immune Signaling Network","description":"The top GO terms span diverse developmental processes across multiple tissues (hindlimb, outflow tract, placenta, Leydig and gonad, mammary gland) and a core transcriptional program (DNA-templated transcription), alongside immune-related activity (cellular response to lipopolysaccharide) and NF-kappaB regulation. This pattern suggests a cluster of proteins that participate in broad developmental regulation while interfacing with immune signaling pathways, rather than a single tissue-specific function. The label reflects both the developmental breadth and the immune signaling connections observed in the terms.","confidence":"Medium","size":17,"edges":21,"triangles":3,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":10},{"id":"GO:0043124","count":10},{"id":"GO:0003148","count":10},{"id":"GO:0035116","count":10},{"id":"GO:0006351","count":10}]},{"hash":"539382911945937858","title":"Neuronal polarity and dendritic spine remodeling","description":"The cluster combines terms tied to neuron development and synaptic formation, including hippocampus development and positive regulation of dendritic spine development, with actin cytoskeleton remodeling via Rac signaling, lamellipodium assembly, and GTPase regulation. Endocytosis and cell polarity maintenance further support neuronal morphology and synapse maintenance. The mitotic spindle term is less neuron-specific but shares cytoskeletal machinery, making the overall theme neuron-specific cytoskeleton dynamics and spine formation.","confidence":"High","size":17,"edges":34,"triangles":13,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071963","count":6},{"id":"GO:0021766","count":6},{"id":"GO:0031532","count":6},{"id":"GO:0016601","count":6},{"id":"GO:0010592","count":6}]},{"hash":"234499336910878184","title":"Unknown","description":"The top GO terms are highly diverse (placenta development, glucose metabolism, transcription regulation, cell size, chemotaxis, hypoxia detection, cocaine response, umami taste, calcium signaling), with no clear shared function or pathway tying the proteins together. This makes it inappropriate to assign a single cohesive label.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001890","count":4},{"id":"GO:0006006","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0045793","count":3},{"id":"GO:0006935","count":3}]},{"hash":"482420226848984258","title":"NF-kappaB signaling and leukocyte chemotaxis","description":"The cluster prominently features terms related to canonical NF-kappaB activation and migration of immune cells (neutrophils and macrophages), pointing to inflammation and leukocyte recruitment as the core theme. Additional terms touch on immune regulation and protein quality control, but the dominant signal is immune signaling with chemotaxis.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0030593","count":3},{"id":"GO:1903026","count":2},{"id":"GO:0007026","count":2}]},{"hash":"32149238986620664","title":"Mesodermal development and organogenesis","description":"The top GO terms cover a range of embryonic development processes tied to mesoderm-derived tissues and organ formation, including cardiac development (right ventricle morphogenesis, cardiac cell fate), mesendoderm development, left-right symmetry determination, kidney development, tooth (odontogenesis) development, and ovarian cumulus expansion. Although the terms span multiple organs, they share a common theme of mesodermal patterning and organogenesis, justifying a single cluster label. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003215","count":1},{"id":"GO:0048378","count":1},{"id":"GO:0001550","count":1},{"id":"GO:0048382","count":1},{"id":"GO:0007368","count":1}]},{"hash":"1881057050934303119","title":"ER Stress and Vesicle Trafficking","description":"This cluster is dominated by GO terms tied to the endoplasmic reticulum and its quality-control pathways, including ER localization, unfolded protein response, and COPII-mediated vesicle budding, plus calcium homeostasis. Together these suggest a role in ER stress management and secretory pathway trafficking; a few terms about host-virus interactions are present but do not redefine the main theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060304","count":3},{"id":"GO:0090114","count":2},{"id":"GO:0006987","count":2},{"id":"GO:0044828","count":2},{"id":"GO:0006874","count":2}]},{"hash":"1164779120955106110","title":"Developmental signaling and organ morphogenesis","description":"The cluster shows multiple GO terms tied to development and signaling across tissues (retina vasculature morphogenesis, atrioventricular valve morphogenesis, proximal/distal pattern formation, cytokine signaling, cell-cell signaling, and regulation of signaling pathways). Although there is an outlier related to sensory perception of sound, the dominant themes point to developmental processes and morphogenesis driven by signaling. Therefore, a cohesive label is Developmental signaling and organ morphogenesis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0007267","count":1},{"id":"GO:0023019","count":1},{"id":"GO:0061299","count":1},{"id":"GO:0042346","count":1}]},{"hash":"585944449371785739","title":"Neuronal development and synaptic signaling","description":"This cluster is dominated by GO terms related to neural development and synaptic function, including motor neuron axon fasciculation, vocalization behavior, NMDA receptor clustering, and neurotransmitter secretion, which together suggest roles in neuronal wiring and synaptic activity. Supporting terms such as Rho signaling, cellular response to forskolin, and transcription indicate broader signaling and gene regulation relevant to neurons. Some terms (notochord formation, male meiotic division) are less directly connected and may reflect broader developmental contexts of the included proteins. Overall, the central theme is neural development and synaptic signaling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097156","count":2},{"id":"GO:0060044","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0014028","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1954258431516308885","title":"Ion transport and signaling in excitable cells","description":"The cluster shows enrichment for sodium and potassium transmembrane transport alongside various signaling pathways (GM-CSF stimulus, thrombin receptor signaling, insulin signaling) and processes like synaptic vesicle exocytosis and striated muscle differentiation, suggesting a role in ion transport and signaling in excitable tissues such as muscle and nervous system.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0070493","count":1},{"id":"GO:0032189","count":1}]},{"hash":"1891736681639977721","title":"Unknown","description":"The top GO terms are diverse, including innate and adaptive immune responses, angiogenesis, leukotriene biosynthesis, various ion transport activities, social behavior, and both long-term synaptic plasticity processes, plus a plant-like cell wall macromolecule catabolic process. There is no clear single function linking all proteins, and the cluster has no edges to indicate a cohesive pathway, so a unified label cannot be confidently assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0002250","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0019370","count":2},{"id":"GO:0035725","count":2}]},{"hash":"2147861481217776182","title":"T cell activation and adhesion signaling with mitochondria","description":"These terms point to immune activation in T cells (costimulation, polarity, cadherin-mediated adhesion, PKC signaling) and related innate signaling (TLR3), with accompanying mitochondrial dynamics (membrane potential, inner membrane organization, stress-induced fusion) suggesting metabolic remodeling during activation. Confidence is high that this label captures the cluster\u2019s core theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034141","count":2},{"id":"GO:0060355","count":2},{"id":"GO:0031295","count":2},{"id":"GO:0010918","count":1},{"id":"GO:0007007","count":1}]},{"hash":"914249488972024653","title":"Cartilage and endochondral bone morphogenesis with ECM remodeling","description":"The cluster\u2019s top GO terms emphasize cartilage development, endochondral ossification, collagen fibril organization and catabolism, and integrin biosynthesis, all pointing to extracellular matrix\u2013mediated skeletal morphogenesis. While a few terms touch on podocyte development, lipoprotein clearance, or PDGF signaling, the dominant theme is ECM remodeling linked to cartilage and bone formation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3},{"id":"GO:0045112","count":3},{"id":"GO:0001958","count":3}]},{"hash":"2031971850776017496","title":"Neuronal development and synaptic organization","description":"This cluster is enriched for neural-specific processes: substantia nigra development, branching morphogenesis of a nerve, neurotransmitter secretion, and clustering of NMDA and AMPA glutamate receptors, all pointing to synaptic assembly and neuronal maturation. A few terms refer to general signaling or metabolism, but the dominant theme is neural development and synaptic organization.","confidence":"High","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021762","count":1},{"id":"GO:0015986","count":1},{"id":"GO:0035786","count":1},{"id":"GO:0007140","count":1},{"id":"GO:0035024","count":1}]},{"hash":"340804461482658247","title":"Mitochondrial import, respiration, and membrane remodeling","description":"The cluster's top GO terms emphasize mitochondrial matrix protein import, inner-membrane insertion, and aerobic respiration, along with protein complex assembly (tetramerization). While a few terms touch on immune regulation and lipid remodeling, the strongest signal is mitochondrial metabolism and membrane-associated processes, with potential secondary links to immune signaling. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043030","count":2},{"id":"GO:0090238","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0045039","count":2}]},{"hash":"1490571245376833931","title":"Embryonic Development and Organ Morphogenesis","description":"The GO terms point to development across multiple tissues (nervous system, lung, thymus, cartilage, heart) and to central growth signaling (ERK/MAPK cascade, AKT activation), suggesting a broad developmental signaling role guiding organ morphogenesis rather than a single specific pathway. The lack of edges reinforces a broad, multi-tissue developmental theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0010765","count":2},{"id":"GO:0032148","count":2},{"id":"GO:0007399","count":2}]},{"hash":"1110021501310694048","title":"RNA Capping and Lipid Metabolism","description":"The cluster shows a clear RNA processing signal via RNA (guanine-N7)-methylation and 7-methylguanosine mRNA capping terms, alongside several lipid catabolic and cofactor biosynthesis processes (lipid and thiamine/thiazole pathways). This suggests a core link to RNA capping with accompanying metabolic roles, justifying the label \u201cRNA Capping and Lipid Metabolism.\u201d","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0006370","count":3},{"id":"GO:0006660","count":3},{"id":"GO:0052651","count":3}]},{"hash":"977468138796425481","title":"Proteostasis and Endomembrane Trafficking Regulation","description":"The top GO terms point to ubiquitin-dependent protein catabolic processes and broad regulation of proteases, together with several vesicle trafficking and localization processes (vacuole fusion, retrograde transport to Golgi, late endosome-to-Golgi transport, Rab signaling). This pattern suggests a cluster of proteins coordinating protein turnover with intracellular trafficking within the endomembrane system, rather than a single enzymatic function. Related regulatory terms (cilium assembly, spindle pole body localization, nitrosylation) support a general theme of modulating protein localization and activity in dynamic cellular contexts. Overall, the cluster seems representative of proteostasis-linked trafficking control.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0010951","count":1},{"id":"GO:0032889","count":1},{"id":"GO:0035526","count":1},{"id":"GO:0034499","count":1}]},{"hash":"972250711980936017","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by ribosome-related processes (ribosome biogenesis, cytoplasmic translation, translation, ribosomal small subunit biogenesis, tRNA modification), indicating the cluster's proteins mostly participate in ribosome assembly and protein synthesis. While a few terms touch on cell cycle and division, the primary theme is ribosome biogenesis and translation, justifying a translation machinery-focused name.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0002181","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0006412","count":3},{"id":"GO:1901001","count":3}]},{"hash":"8511332629646156","title":"Neural development and tissue morphogenesis","description":"The terms cluster around neural development (synapse assembly, axonal fasciculation, neuron migration) and cell adhesion (homophilic adhesion, Rho signaling), with additional organ morphogenesis terms (epithelium morphogenesis, odontogenesis, kidney development). This suggests a broad theme of developmental processes, especially neural development and tissue morphogenesis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0007266","count":2}]},{"hash":"318054744288606762","title":"Cardiac and retinal development","description":"The top GO terms are dominated by heart development and ventricular morphogenesis as well as retinal cone cell development, indicating proteins involved in development of cardiac and visual tissues. Additional terms like thyroid hormone receptor signaling and NF-kappaB regulation point to broader developmental signaling contexts, while immune-related terms may reflect shared regulatory pathways. Overall, the strongest signal is organ development in heart and retina, supporting the label Cardiac and Retinal Development.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046549","count":4},{"id":"GO:1903799","count":4},{"id":"GO:0055010","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0071222","count":3}]},{"hash":"2279104248974155511","title":"Metabolic and inflammatory regulation in adipose and immune tissues","description":"GO terms cluster around metabolic control (glucose import in response to insulin, thyroid hormone signaling) and adipocyte differentiation, together with immune/inflammatory processes (foam cell differentiation, lipopolysaccharide response, negative regulation of inflammatory response) and lysosomal enzyme secretion. The common thread is cross-talk between metabolism and immune signaling in adipose and immune contexts, though the terms span several related processes rather than a single pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0002155","count":3},{"id":"GO:0010745","count":3},{"id":"GO:0051546","count":3},{"id":"GO:0045444","count":3}]},{"hash":"1452393236394718369","title":"Cartilage formation and collagen remodeling","description":"This cluster is enriched for collagen-related processes: collagen fibril organization, collagen catabolic process, and cartilage condensation, which together point to extracellular matrix remodeling and cartilage development as the core theme. Other terms (meiotic cell cycle, centrosome duplication, lipopolysaccharide response, axonogenesis, transcription) suggest additional or broader roles, but the collagen/ECM signals are the strongest common thread. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051321","count":2},{"id":"GO:0051298","count":2},{"id":"GO:0015966","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0030574","count":2}]},{"hash":"570869780232604209","title":"Meiosis and oocyte maturation","description":"Based on the enrichment of terms focused on oocyte maturation, female meiotic spindle assembly, microtubule dynamics, and SCF-dependent ubiquitin-proteasome protein degradation, the proteins in this cluster appear to function together in meiosis and related cell-cycle regulation during oogenesis.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":12},{"id":"GO:0046785","count":12},{"id":"GO:0021678","count":12},{"id":"GO:0021993","count":12},{"id":"GO:0070544","count":12}]},{"hash":"2177635885204370349","title":"Developmental Axon Growth and Vesicle Trafficking","description":"Top GO terms indicate a shared focus on neural development (axon extension) and intracellular transport (COPII-coated vesicle budding), with supporting signals from development-related apoptosis, calcium homeostasis, and stress responses. The core theme appears to be proteins coordinating axon growth during development alongside ER-to-Golgi vesicle trafficking, with some additional developmental and host-interaction annotations that may be incidental. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048675","count":2},{"id":"GO:1904747","count":1},{"id":"GO:1902742","count":1},{"id":"GO:0018991","count":1},{"id":"GO:0090114","count":1}]},{"hash":"103062373167247946","title":"Aggresome-Associated Ubiquitin Proteolysis","description":"The top GO terms point to ubiquitin-dependent protein catabolic processes, monoubiquitination/deubiquitination, and aggresome assembly, suggesting a focus on proteostasis and quality control rather than a single signaling or developmental pathway. While a few terms (e.g., microtubule polymerization, glycoprotein catabolic process) are collateral, the central theme is ubiquitin-mediated degradation and aggresome formation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070842","count":2},{"id":"GO:0010216","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0036353","count":2},{"id":"GO:0035520","count":2}]},{"hash":"1845459997575581383","title":"Endolysosomal trafficking and autophagy","description":"Proteins in this cluster are linked to endosomal vesicle fusion, Golgi-to-lysosome transport, Golgi organization, lysosome targeting, and autophagy (aggrephagy), with additional cues from ER network formation and cytoskeletal remodeling (filopodium assembly). The common theme is intracellular membrane trafficking within the endolysosomal system, integrated with autophagy-related pathways, rather than a single enzymatic function. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035973","count":1},{"id":"GO:0034141","count":1},{"id":"GO:0034145","count":1},{"id":"GO:1903358","count":1},{"id":"GO:0048549","count":1}]},{"hash":"2013683109450966582","title":"Neural development and cell polarity","description":"This cluster centers on neural tissue organization and development, with terms like dendrite development, planar cell polarity pathway (neural tube closure), and establishment of epithelial polarity, plus localization related to myelin sheath. Receptor clustering and JNK pathway regulation fit into signaling dynamics during neural differentiation and morphogenesis. The mix of neural-specific and polarity-related terms suggests a cohesive theme around neural development and cellular polarity, with a few broader signals contributing noise. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0008285","count":5},{"id":"GO:0046328","count":5},{"id":"GO:0090179","count":4},{"id":"GO:0035750","count":4},{"id":"GO:0045198","count":4}]},{"hash":"966589226273856538","title":"Unknown","description":"The proteins in this cluster are annotated with a highly diverse set of GO terms, spanning signaling regulation, post-translational modification, transcription, metabolism, and even retina/visual perception, plus a bacterial antigen biosynthetic process. With no clear unifying function or interaction pattern (Edges 0, Triangles 0), there is no coherent theme that ties the group together, so the safe label is Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0009246","count":1},{"id":"GO:0016567","count":1},{"id":"GO:0071879","count":1},{"id":"GO:0090327","count":1}]},{"hash":"229886354756640407","title":"Rho signaling and synapse organization","description":"This cluster centers on Rho protein signal transduction and its regulation, with strong ties to receptor clustering, synapse organization, and localization processes (secretory granules and cell junctions). The convergence of these terms suggests a theme of signaling dynamics at synapses and cell\u2013cell contacts governed by Rho pathways, despite a few related signaling terms appearing in broader contexts.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0043113","count":3},{"id":"GO:0030318","count":3},{"id":"GO:0006470","count":3},{"id":"GO:0032252","count":3}]},{"hash":"511022350040114831","title":"Neuromodulation and Behavior","description":"The cluster\u2019s top GO terms cluster around neuromodulators and behavioral outcomes: norepinephrine biosynthesis, octopamine signaling, dopamine catabolic processes, memory, fear, and behavioral responses to ethanol. This points to a coherent theme of neuromodulatory signaling shaping behavior and learning. While terms like leukocyte migration and lipid storage appear, they are less defining for the cluster\u2019s primary function, suggesting peripheral roles rather than central drivers of the cluster\u2019s identity.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050900","count":2},{"id":"GO:0048149","count":2},{"id":"GO:0019915","count":2},{"id":"GO:0042421","count":1},{"id":"GO:0042596","count":1}]},{"hash":"831959578971983306","title":"Actin-driven cell migration","description":"Top terms indicate strong enrichment for microspike and lamellipodium assembly and neutrophil chemotaxis, classic hallmarks of actin-based cell movement. Insulin/IGF signaling-related terms and glucose import in response to insulin stimulus suggest some signaling cross-talk that can influence migration, but they are secondary to the cytoskeletal theme. The manganese transport and apoptotic mitochondrial changes appear tangential to the core function, possibly reflecting broader metabolic or stress responses. Overall, the cluster most coherently reflects actin-driven protrusion and cell migration, with ancillary signaling associations.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0030593","count":3},{"id":"GO:0043552","count":3}]},{"hash":"2194929689930046600","title":"Planar polarity and wing hair orientation","description":"These proteins are linked by terms about planar cell polarity, establishment of wing hair/bristle orientation in imaginal discs, and related polarity localization, with supporting associations to Wnt signaling and head morphogenesis. The strongest and most coherent theme is planar polarity-driven wing morphogenesis, making this label representative of the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042331","count":1},{"id":"GO:0001737","count":1},{"id":"GO:0048104","count":1},{"id":"GO:0007614","count":1},{"id":"GO:0021903","count":1}]},{"hash":"1603267141716746663","title":"Endosomal trafficking and surface protein localization","description":"The top GO terms center on endosome-to-lysosome transport, intralumenal vesicle formation, and phosphatidylinositol signaling, all indicative of endomembrane trafficking. Positive and negative regulation of protein localization to the cell surface further point to delivery of proteins to the plasma membrane. Some terms about eye development, gliogenesis, and bone development suggest these trafficking processes are important in developmental contexts. Overall, the cluster seems cohesive around vesicle trafficking and protein localization with developmental associations.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":2},{"id":"GO:2000637","count":2},{"id":"GO:0036089","count":1},{"id":"GO:0070676","count":1},{"id":"GO:0001654","count":1}]},{"hash":"1816189540220061118","title":"Organelle Protein Targeting and RNA Regulation","description":"The top GO terms cluster around import and targeting of proteins into organelles (mitochondrial matrix, chloroplast stroma, inner membrane) and related RNA processing/regulation activities (RNA transport and ncRNA-mediated post-transcriptional gene silencing). While some terms are obsolete or peripheral (viral process, ubiquitin recycling), the dominant theme is proteins being directed to organelles and associated RNA regulatory processes, suggesting a cohesive label focused on organelle targeting and RNA regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":1},{"id":"GO:0000002","count":1},{"id":"GO:0032094","count":1},{"id":"GO:0045037","count":1},{"id":"GO:0030150","count":1}]},{"hash":"466125367319872159","title":"Nematode molting and pharyngeal pumping","description":"These proteins are annotated with strong nematode-specific developmental terms, especially molting cycles and nematode pharyngeal pumping, which suggests a cluster focused on nematode development and feeding-related processes. While there are additional RNA metabolism and broad developmental terms present, the dominant signals point toward nematode developmental regulation. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":5},{"id":"GO:0043050","count":5},{"id":"GO:0000288","count":2},{"id":"GO:0097403","count":1},{"id":"GO:1904582","count":1}]},{"hash":"1461623715540439709","title":"Nuclear transcription and RNA processing","description":"The GO terms cluster around transcription and mRNA processing (DNA-templated transcription, snRNA transcription by RNA polymerase II/III, mRNA processing), indicating a shared nuclear transcription/ RNA processing function, with a few developmental or stress-response terms likely reflecting broader context.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042795","count":2},{"id":"GO:0042796","count":2},{"id":"GO:0001890","count":2}]},{"hash":"1738106418137533121","title":"Plant cell wall remodeling and plasmodesmata organization","description":"The dominant GO terms point to plant-type cell wall modification, regulation of cellulose biosynthesis, and plasmodesma organization, suggesting coordinated cell wall remodeling and intercellular transport in response to wounding. While a few other terms (e.g., DNA repair, FMN metabolism) seem less connected, the core theme remains plant cell wall dynamics and plasmodesmatal communication.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":4},{"id":"GO:2001009","count":4},{"id":"GO:0009663","count":4},{"id":"GO:0009611","count":3},{"id":"GO:0006281","count":2}]},{"hash":"1701624673939827414","title":"Membrane transporters and secretion proteins","description":"Most terms describe transport or secretion across membranes (ion transport, nutrient/xenobiotic transport, vitamin transport, pH regulation, and Type I secretion), with a few outliers like sperm capacitation and MHC I antigen processing.","confidence":"Medium","size":16,"edges":66,"triangles":120,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":2},{"id":"GO:0035461","count":1},{"id":"GO:0030253","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0051454","count":1}]},{"hash":"1185325938138630442","title":"Dopaminergic sensory signaling and cocaine response","description":"Dominant GO terms cluster around neural signaling and sensory processing: dopaminergic synaptic transmission, visual perception and learning, pain perception, and cocaine-related behavioral responses, with ERK cascade regulation reflecting neuronal signaling. A few outliers (heart development, prostaglandin response) do not override the overall neural/sensory theme.","confidence":"Medium","size":16,"edges":10,"triangles":4,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0019233","count":9},{"id":"GO:0071380","count":9},{"id":"GO:0010759","count":9},{"id":"GO:0048148","count":9}]},{"hash":"1309482634467668635","title":"Unknown","description":"The GO terms across this cluster span transcription regulation, ubiquitination, RNA processing, and stress response, but also include seemingly unrelated processes (endothelin-regulated blood pressure, nitrate assimilation, blastocyst formation). There is no clear, cohesive theme tying the proteins together, so a specific functional label cannot be confidently assigned.","confidence":"","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003100","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0042128","count":2},{"id":"GO:1902625","count":2}]},{"hash":"2103652654191486683","title":"Actin cytoskeleton remodeling and membrane signaling","description":"This cluster is dominated by GO terms related to actin dynamics (positive regulation of actin nucleation, Arp2/3-mediated actin nucleation, cell migration, cell shape, polarity) and membrane-associated signaling (PDGF receptor signaling, T cell receptor signaling, plasma membrane raft distribution). Together these suggest a coordinated program of actin remodeling at the plasma membrane that governs adhesion, migration, polarity, and barrier properties, with signaling pathways linking receptors to cytoskeletal changes. The presence of a few membrane transport terms does not override the dominant actin-centered theme. ","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0051127","count":2},{"id":"GO:0048008","count":2},{"id":"GO:0050731","count":2}]},{"hash":"1710347871633789626","title":"Developmental Transcription and Signaling","description":"These proteins show enrichment for DNA-templated transcription and signaling pathways (p38 MAPK cascade, retinoic acid response) and developmental processes (face and vagina development, adipocyte differentiation). The inclusion of cellular responses to lipopolysaccharide suggests inflammatory signaling interactions with these developmental programs, indicating a cluster of factors coordinating transcriptional regulation and signaling in development with some immune responsiveness.","confidence":"Medium","size":16,"edges":11,"triangles":5,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0071222","count":6},{"id":"GO:2001275","count":6},{"id":"GO:0060068","count":6},{"id":"GO:0043433","count":6}]},{"hash":"1868968062987719288","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072752","count":1},{"id":"GO:1990928","count":1},{"id":"GO:0034414","count":1},{"id":"GO:0006396","count":1},{"id":"GO:0007053","count":1}]},{"hash":"1751787598341925822","title":"RNA Processing and Translation Regulation","description":"The cluster is dominated by GO terms tied to post-transcriptional control: alternative splicing via the spliceosome, mRNA export and stability, mRNA modification, and translation initiation/reinitiation (including IRES-dependent initiation). This suggests a cohesive theme of RNA processing and regulation of protein synthesis, rather than a single linear pathway.","confidence":"High","size":16,"edges":105,"triangles":388,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000380","count":5},{"id":"GO:1902625","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0001825","count":4},{"id":"GO:0010610","count":4}]},{"hash":"982314719240176385","title":"RNA processing and translation regulation","description":"These terms cluster around RNA metabolism and the control of translation\u2014mRNA export, splicing regulation, mRNA modification and stability, plus initiation and reinitiation of translation (including IRES-dependent initiation). This pattern suggests a cohesive theme of post-transcriptional gene expression regulation, despite a few unrelated terms. ","confidence":"High","size":16,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:1902625","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0010610","count":3}]},{"hash":"1720703446287564597","title":"Lectin- and complement-mediated innate immunity","description":"The top GO terms point strongly to innate immune signaling: complement activation via the lectin pathway, basophil activation, C-type lectin receptor signaling, response to fungal origin, and NK cell chemotaxis regulation. While a few terms relate to tissue morphogenesis (kidney and lymph vessel development) that may reflect multifunctional or incidental annotations, the dominant pattern ties to lectin/complement\u2013driven immune responses.","confidence":"Medium","size":16,"edges":19,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0045575","count":7},{"id":"GO:0072237","count":7},{"id":"GO:0036303","count":7},{"id":"GO:0072287","count":7}]},{"hash":"635482721569370731","title":"Vesicle trafficking and mitosis","description":"It is dominated by vesicle trafficking between ER and Golgi (COPII budding) and microtubule-based movement, including mitotic spindle assembly and cell division, pointing to a module where intracellular transport is tied to mitosis and proliferation. Brain development and growth terms suggest developmental roles of this transport machinery, while a few terms (splicing, GTPase regulation) may reflect additional, ancillary functions within the cluster.","confidence":"High","size":16,"edges":75,"triangles":159,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0035264","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0008283","count":2}]},{"hash":"2190104207478349631","title":"Calcium-dependent exocytosis and synaptic signaling","description":"Proteins in this cluster are enriched for GO terms tied to calcium-triggered exocytosis (acrosome reaction; fast Ca2+-dependent neurotransmitter release) and synaptic potentiation, with related Ca2+ signaling via IP3 biosynthesis. This suggests a common theme of Ca2+-driven membrane fusion and rapid signaling at secretory or synaptic interfaces, even though a few annotations (e.g., immune regulation, transcription) may reflect broader roles of some proteins. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":2},{"id":"GO:0098746","count":1},{"id":"GO:1990926","count":1},{"id":"GO:0046642","count":1},{"id":"GO:0043619","count":1}]},{"hash":"574002958827697121","title":"Neurodevelopment with Angiogenesis and Innate Immunity","description":"The top GO terms point to developmental programs (CNS development, cartilage condensation, angiogenesis, DNA-templated transcription, receptor clustering) while also highlighting innate immune responses (cellular responses to fungal origin and LPS, phagocytosis recognition). This suggests a cluster of proteins involved in development and associated immune signaling or tissue remodeling.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":3},{"id":"GO:0071226","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0006910","count":2},{"id":"GO:0071222","count":2}]},{"hash":"1082114077511989843","title":"Splicing Regulation in Development and Immunity","description":"This cluster shows strong enrichment for alternative splicing via the spliceosome (GO:0000380 and GO:0000381), suggesting splicing regulation as a unifying feature. It also includes developmental processes (granulocyte differentiation, in utero embryonic development, neuron projection development) and innate immune responses, plus related regulatory activities like chromatin binding. Taken together, it points to a coordinated program where splicing control modulates both development and immune differentiation.","confidence":"Medium","size":16,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030851","count":2},{"id":"GO:0000380","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0010976","count":2}]},{"hash":"1666552581071156080","title":"Drosophila oogenesis and germline cyst formation","description":"The top GO terms cluster around ovarian development in Drosophila, including ovarian fusome organization, oocyte karyosome formation, and germarium-derived germ-line cyst formation, with supporting signals from ubiquitin-proteasome\u2013dependent protein catabolism and RNA regulation that are characteristic of developmental control during oogenesis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":2},{"id":"GO:1901253","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0050779","count":1},{"id":"GO:0030723","count":1}]},{"hash":"2106245514154712437","title":"Rho/Ras GTPase signaling and actin dynamics","description":"The cluster is defined by enrichment of GO terms related to small GTPase signaling (Ras, Rho) and actin cytoskeleton remodeling (filopodium/microspike assembly, cytoskeleton reorganization). Additional terms like centrosome localization and membrane invagination point to roles in polarized cell shape changes and endocytosis; occasional innate immune response term suggests immune-related cytoskeletal functions. Overall, the set likely comprises proteins coordinating small GTPase\u2013driven signaling to reorganize the actin cytoskeleton, affecting membrane dynamics and synaptic plasticity (long-term depression).","confidence":"Medium","size":16,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":2},{"id":"GO:0007264","count":2},{"id":"GO:2000251","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0051660","count":2}]},{"hash":"951830182583070316","title":"Sodium Transport and Sensory Perception","description":"These terms converge on two related themes: sodium ion transmembrane transport/homeostasis and sensory signaling that underpins taste, touch, and pain perception, with a note on modulation of neurotransmitter release. The presence of both ion transport and multiple sensory perception GO terms suggests the cluster functions in neuronal signaling where sodium flux couples to sensory input and synaptic regulation.","confidence":"Medium","size":16,"edges":77,"triangles":140,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":1},{"id":"GO:1905789","count":1},{"id":"GO:0055078","count":1},{"id":"GO:0050915","count":1},{"id":"GO:0050965","count":1}]},{"hash":"934403730993168058","title":"Neuronal development and protein synthesis","description":"The Top Terms show neuronal growth signals (positive regulation of neuron projection development, neuron projection extension) together with translation-related processes (translation, ribosome biogenesis, preribosome assembly). This suggests the cluster reflects neuronal growth programs that require active protein synthesis, with some metabolic terms present but secondary to the main theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0090070","count":1},{"id":"GO:1902626","count":1}]},{"hash":"1804445383129503106","title":"Unknown","description":"The GO terms span immune response (lipopolysaccharide), multiple developmental contexts (vagina and prostate glandular tissue), various metabolic and signaling processes (bile acid metabolism, cholesterol homeostasis, thyroid hormone signaling, NF-kappaB regulation), and lysosomal enzyme secretion, with only one edge and no triangles. This lack of a cohesive functional theme suggests the proteins do not share a common, interpretable function as a cluster, so the label Unknown is most appropriate.","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":7},{"id":"GO:0060068","count":7},{"id":"GO:0008206","count":7},{"id":"GO:0042632","count":7},{"id":"GO:0035264","count":6}]},{"hash":"579962068599991723","title":"Embryonic development and tissue morphogenesis","description":"GO terms indicate embryonic development and diverse tissue morphogenesis (eye, hindlimb, heart outflow tract, placenta, habenula, prostate, gonad). The transcriptional regulation term suggests developmental control, supporting a broad embryonic development program rather than a single tissue. ","confidence":"High","size":16,"edges":10,"triangles":0,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":7},{"id":"GO:0001701","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0003148","count":5},{"id":"GO:0035116","count":5}]},{"hash":"1931120020682126426","title":"Transmembrane amino acid and small-molecule transporters","description":"The cluster shows strong enrichment for transmembrane transport GO terms, including specific amino acid transports (glutamate, threonine, serine, aspartate) and other small molecules (sodium ions, arabinose, vitamins, etc.), suggesting these proteins function broadly as membrane transporters for amino acids and related metabolites. The presence of diverse substrate terms supports a general transporter theme rather than a single substrate.  ","confidence":"High","size":16,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055085","count":1},{"id":"GO:0051938","count":1},{"id":"GO:0015826","count":1},{"id":"GO:0009449","count":1},{"id":"GO:0070779","count":1}]},{"hash":"788195147354534206","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms span diverse developmental and morphogenetic processes across multiple tissues, including pancreatic and endocrine development, placental/mesoderm differentiation, hair follicle morphogenesis, cartilage and palate formation, and EMT events in heart development. This suggests a general theme of embryonic tissue development and organogenesis rather than a single tissue-specific function.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0007498","count":1},{"id":"GO:0060806","count":1}]},{"hash":"1232040626269830621","title":"Bacterial lipid metabolism and cell-wall biosynthesis","description":"The top GO terms cluster around lipid production and metabolism (lipoteichoic acid biosynthesis, fatty acid biosynthetic and metabolic processes, fatty acid transport) and related energy pathways (acetyl-CoA biosynthesis, pyruvate fermentation to acetate), which are characteristic of bacterial cell-wall biosynthesis and membrane lipid production. While a couple of terms (seed germination, phenylpropanoid metabolism) are outliers, the dominant theme is bacterial lipid metabolism and cell-wall component biosynthesis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":10},{"id":"GO:0019290","count":9},{"id":"GO:0001579","count":9},{"id":"GO:0001676","count":9},{"id":"GO:0019427","count":9}]},{"hash":"637142755752215880","title":"Insect olfactory regulation of oviposition and mating","description":"The terms cluster around chemosensory detection (olfactory behavior, detection of chemical stimulus, sensory perception of chemical stimulus) and reproductive behaviors (regulation of egg-laying, negative regulation of egg-laying, female receptivity post-mating), plus larval locomotion, suggesting a group of proteins involved in odor-guided decisions that influence reproduction in insects.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045434","count":2},{"id":"GO:0048042","count":2},{"id":"GO:0002209","count":2},{"id":"GO:1901045","count":2},{"id":"GO:0008345","count":2}]},{"hash":"2116597537261981016","title":"Visual system and photoreceptor maintenance","description":"The GO terms are dominated by visual perception, photoreceptor maintenance, visual learning, and dopaminergic synaptic transmission, pointing to a cluster of proteins involved in retina/visual signaling and photoreceptor stability. While inflammatory-related terms appear, the strongest signal centers on vision-related processes, supporting a coherent visual system theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":3},{"id":"GO:0001662","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0045494","count":2},{"id":"GO:0070374","count":2}]},{"hash":"457135194682429030","title":"Developmental signaling and ion transport","description":"The top terms are dominated by multicellular organism development, including outflow tract morphogenesis and ossification, indicating a developmental program. Supporting terms involve ion transport (potassium and sodium flux) and second-messenger signaling (cGMP and cAMP), suggesting a link between developmental processes and signaling/ion regulation. A few terms (aerotaxis, pain perception) are less directly related, but do not outweigh the central developmental theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0071805","count":5},{"id":"GO:0071321","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0009454","count":5}]},{"hash":"897116809239518569","title":"Unknown","description":"The GO terms are scattered across diverse functions (ERAD regulation, wing patterning, neurodeath regulation, sodium transport/homeostasis, and multiple sensory perceptions). There isn\u2019t a clear, unifying theme tying these proteins into a single coherent function, so a descriptive yet informative single-label name cannot be confidently assigned.","confidence":"","size":16,"edges":40,"triangles":22,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1904294","count":1},{"id":"GO:0048190","count":1},{"id":"GO:1901215","count":1},{"id":"GO:0035725","count":1},{"id":"GO:1905789","count":1}]},{"hash":"1611275577235540026","title":"Potassium Ion Transport and Membrane Potential Regulation","description":"This cluster is dominated by GO terms centered on intracellular potassium homeostasis, stabilization and regulation of membrane potential, and potassium ion transport, including atrial cardiac muscle repolarization. These terms point to a common function in electrophysiological maintenance and ion channel/pump activity. Some sensory-related terms appear but are secondary to the core potassium/membrane potential theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":7},{"id":"GO:0030322","count":6},{"id":"GO:0098914","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0060075","count":6}]},{"hash":"2266579265140463608","title":"Neural signaling and behavior regulation","description":"This cluster is dominated by GO terms related to behavioral control (regulation of egg-laying behavior, negative regulation of female receptivity, larval locomotory behavior, behavioral defense response) and neural signaling/development (adenylate cyclase-inhibiting opioid receptor signaling, cerebral cortex GABAergic interneuron migration). While a few terms touch on metabolism or systemic regulation, the core theme points to neural control of behavior, making \u201cNeural signaling and behavior regulation\u201d a concise, representative label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048042","count":5},{"id":"GO:0045434","count":5},{"id":"GO:0008345","count":5},{"id":"GO:0002209","count":5},{"id":"GO:1901045","count":5}]},{"hash":"330732777196817406","title":"Actin-based immune cell motility and signaling","description":"This cluster centers on lamellipodium and filopodium assembly, Rac/Ras signaling regulation, and cell spreading, all hallmark features of actin cytoskeletal remodeling. Coupled with innate immune response and T/B cell\u2013related processes, the terms suggest a theme of cytoskeletal reorganization accompanying immune cell activation and migration.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0007205","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0002344","count":2}]},{"hash":"576009836965380524","title":"Intracellular trafficking and localization regulators","description":"This cluster is driven by GO terms related to vesicle transport and localization, including retrograde transport to the Golgi, endosome-to-Golgi transport, and Rab protein signal transduction, suggesting a shared role in intracellular trafficking and protein localization. While transcription-related terms are also present, the trafficking/localization signatures appear more representative of the cluster\u2019s core function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0001958","count":2},{"id":"GO:0006367","count":1},{"id":"GO:0042795","count":1},{"id":"GO:0032889","count":1}]},{"hash":"2067220127394470446","title":"Sterol and lipid biosynthesis","description":"Top GO terms are dominated by lipid and sterol metabolism, including fatty acid biosynthesis, ergosterol and cholesterol biosynthetic processes, and sphingolipid metabolism; CNS myelin maintenance also links to lipid-rich membranes. Despite no edges, the common thread is lipid/sterol biosynthesis and lipid-related membrane processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046485","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0035754","count":2},{"id":"GO:0080064","count":2}]},{"hash":"2189700468351697671","title":"Zinc Ion Transport and Homeostasis","description":"The cluster\u2019s top GO terms are dominated by zinc-related processes, including zinc ion import across membranes, detoxification, and cellular response to zinc starvation, which together suggest a zinc-handling or homeostasis function. Some terms (chloroplast thylakoid protein import, spindle assembly, transcription regulation) appear as outliers, possibly reflecting multifunctional proteins or annotation noise. Overall, zinc ion transport and homeostasis best explains the shared theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045038","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1903615","count":1}]},{"hash":"800908984015912519","title":"Skeletal development and ECM remodeling","description":"This cluster centers on skeletal development and extracellular matrix (ECM) organization. High-frequency terms include endochondral ossification, cartilage development, collagen fibril organization, and collagen catabolic process, all core to bone growth and ECM remodeling. Additional terms for integrin biosynthesis and ECM turnover support a cohesive ECM-related function; a few kidney/podocyte and lipoprotein-related terms are present but less central to the main signal.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":7},{"id":"GO:0033034","count":7},{"id":"GO:0060351","count":7},{"id":"GO:0045112","count":7},{"id":"GO:0001958","count":7}]},{"hash":"1127526994415842420","title":"Nucleophagy and organelle autophagy","description":"This cluster\u2019s top GO terms cluster around autophagy-related processes, including macroautophagy, mitophagy (autophagy of mitochondrion), and piecemeal microautophagy of the nucleus (nucleophagy), along with related protein lipidation and membrane-targeting steps essential for autophagosome formation. This coherent set of autophagy- and organelle turnover-related functions justifies labeling the group as nucleophagy and organelle autophagy. Some terms like translation or neuronal development appear incidental and less central to the core theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0045732","count":1},{"id":"GO:0051697","count":1},{"id":"GO:0034727","count":1},{"id":"GO:0016236","count":1}]},{"hash":"440205136245017454","title":"ER glycoprotein processing and ERAD","description":"Dominant themes are ER-based glycoprotein processing, especially mannose trimming and trafficking to the cytosol for degradation (ERAD). The GO terms link glycosylation/trimming in ER and Golgi to the ERAD pathway and retrograde ER-to-cytosol transport, indicating an ER quality-control cluster.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":1},{"id":"GO:0097466","count":1},{"id":"GO:0036512","count":1},{"id":"GO:0036510","count":1},{"id":"GO:1904154","count":1}]},{"hash":"1629095706418640327","title":"ER Stress and Protein Trafficking","description":"The dominant GO terms point to endoplasmic reticulum functions: COPII-coated vesicle budding, protein localization to the ER, and the ER unfolded protein response, along with calcium homeostasis linked to ER function. Together these suggest proteins involved in ER quality control and ER-to-Golgi transport. Some viral-host interaction terms appear, but the core theme remains ER stress and trafficking pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":2},{"id":"GO:0006987","count":2},{"id":"GO:0044828","count":2},{"id":"GO:0006874","count":2},{"id":"GO:0044829","count":2}]},{"hash":"225259173768525759","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":2},{"id":"GO:0030150","count":1},{"id":"GO:0045040","count":1},{"id":"GO:0046639","count":1},{"id":"GO:0061053","count":1}]},{"hash":"1526804763128007290","title":"Ubiquitin-Dependent Proteolysis and Signaling","description":"Top terms center on ubiquitin-mediated protein degradation and ubiquitin signaling (autoubiquitination, K63/K6 linkages). Related terms include TNF/apoptosis regulation and histone ubiquitination, indicating chromatin and signaling roles of ubiquitin. A V(D)J recombination term is secondary but fits ubiquitin's involvement in DNA processing. Overall, it's a ubiquitin-driven proteostasis and signaling cluster.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0051865","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0070534","count":5},{"id":"GO:0070512","count":5}]},{"hash":"890084404587047990","title":"Development and Cytoskeletal Organization","description":"The Top Terms point to broad developmental processes (multicellular development, flower development) combined with structural/cytoskeletal organization (intermediate filaments, nuclear membrane, eye pigment granules, cuticle). Although there is species diversity and some terms are obscure/obsolete, the common thread is development intertwined with cellular architecture, justifying a label focused on both aspects.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0009911","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0043050","count":2},{"id":"GO:0008057","count":1}]},{"hash":"712569374758376684","title":"Cartilage Condensation Signaling","description":"These proteins are enriched for terms tied to cartilage development and morphogenesis, notably cartilage condensation, cell adhesion, collagen-activated receptor signaling, and negative regulation of Wnt signaling. Together, these point to coordinated cell\u2013matrix interactions and signaling events driving cartilage formation. The presence of ER stress and general signaling terms (MAP kinase, p53) adds some noise, so the label is plausible but not exclusive. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007095","count":2},{"id":"GO:0030968","count":2},{"id":"GO:0090090","count":2},{"id":"GO:0038063","count":2},{"id":"GO:0007155","count":2}]},{"hash":"1920622803091758331","title":"Ribosome Biogenesis and Quality Control","description":"The cluster\u2019s top GO terms are centered on ribosome production and maintenance: ribosome biogenesis, rescue of stalled ribosomes, and ribosome-associated ubiquitin-dependent protein catabolic process, indicating a cohesive role in ribosome assembly and quality control. Some transcription-related terms and developmental processes appear as secondary associations but do not dominate the theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0008542","count":2},{"id":"GO:1990116","count":1},{"id":"GO:0072344","count":1},{"id":"GO:0006366","count":1}]},{"hash":"1660456747363787051","title":"Developmental transcriptional regulation","description":"These proteins show broad involvement in developmental processes across multiple tissues (heart outflow tract, placenta, trachea, habenula, prostate, gonads) and include transcription-related GO terms (DNA-templated transcription; regulation of RNA Pol II preinitiation complex assembly). The shared theme is regulation of gene expression during development, rather than a single tissue-specific function. Confidence: High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0070384","count":4},{"id":"GO:0017055","count":4},{"id":"GO:0001890","count":4}]},{"hash":"1288265007742133658","title":"Innate Immune Signaling and Tissue Remodeling","description":"This cluster combines innate immune signaling terms (cellular response to lipopolysaccharide, TLR7 signaling, NF-kappaB pathway, cytokine signaling) with processes related to tissue remodeling and development (collagen fibril organization, lymph vessel morphogenesis, VEGF signaling, myelination, axon guidance, kidney size regulation). The proteins likely participate in immune responses while also influencing vascular, neural, and structural remodeling, suggesting a broad role in inflammation-associated development rather than a single specialized pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0071222","count":2},{"id":"GO:0042346","count":2},{"id":"GO:0034154","count":2},{"id":"GO:0048846","count":2}]},{"hash":"1485607910281483576","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001824","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0042274","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0000472","count":1}]},{"hash":"85828026056467064","title":"Olfactory Chemosensory Detection","description":"The cluster is driven by GO terms related to detection of chemical stimuli and olfactory behavior, suggesting a shared chemosensory function. The other terms (follicle epithelium polarity, seed coat mucilage, root hair development, various glycosylation processes) are sporadic and do not form a cohesive alternative theme, so the strongest signal points to chemosensory activity. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":4},{"id":"GO:0042048","count":3},{"id":"GO:0042248","count":1},{"id":"GO:0075015","count":1},{"id":"GO:0007299","count":1}]},{"hash":"280192932191009223","title":"Ubiquitin-Dependent Proteolysis and Cell Cycle Regulation","description":"The cluster is best characterized by ubiquitin-related regulation (ubiquitin-dependent catabolic process and protein ubiquitination) along with DNA damage response and cell cycle control signals (p53-mediated DDR, mitotic start control point, and apoptosis regulation), suggesting a module focused on protein turnover governing checkpoint signaling and cell cycle progression. Some heart-development terms and methylation annotations appear secondary or incidental to the main theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0032259","count":1},{"id":"GO:0030488","count":1},{"id":"GO:0016567","count":1},{"id":"GO:0071494","count":1}]},{"hash":"76538109936112884","title":"Mitochondrial stress and hypoxia signaling","description":"These GO terms center on mitochondrial function and cellular stress responses: ROS regulation, regulation of aerobic respiration, and mitochondrial protein turnover, combined with autophagy promotion and modulation of apoptotic pathways in response to hypoxia. The cellular response to hypoxia and hypoxia-induced signaling further tie these processes together, suggesting a mitochondrial stress response program that governs survival via autophagy and apoptosis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":1},{"id":"GO:1903715","count":1},{"id":"GO:0035694","count":1},{"id":"GO:1901998","count":1},{"id":"GO:0071260","count":1}]},{"hash":"2277741657818012393","title":"Olfactory sensing and neuronal signaling","description":"The GO terms cluster around detection of chemical stimuli and olfactory behavior, with supporting neuronal signaling (neurotrophin TRK pathway) and actin cytoskeleton roles, suggesting a sensory-neuron\u2013related function. Some terms (ER stress translation regulation, subtelomeric heterochromatin formation) appear peripheral but do not override the main theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0060670","count":2},{"id":"GO:0042048","count":2},{"id":"GO:0036493","count":1}]},{"hash":"2058466549018899113","title":"Female meiosis and oocyte maturation","description":"The cluster is enriched for terms tied to female meiosis and oocyte development, such as oocyte maturation, spindle assembly in female meiosis I, and microtubule polymerization, along with ubiquitin-proteasome\u2013mediated proteolysis, all pointing to meiosis-specific cell cycle progression in oocytes. While some neural development terms appear, the dominant signal centers on meiotic spindle dynamics and oocyte maturation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":7},{"id":"GO:0046785","count":7},{"id":"GO:0021678","count":7},{"id":"GO:0021993","count":7},{"id":"GO:0070544","count":7}]},{"hash":"2037505061803054178","title":"Unknown","description":"The GO terms cover cholesterol homeostasis and efflux, sperm motility, general transport, circadian regulation, neural/behavioral responses, UV-A response, and IGF signaling, with no clear single theme linking most proteins. This makes it not possible to assign a cohesive, high-level label beyond Unknown. ","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010875","count":2},{"id":"GO:0030317","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0098703","count":2},{"id":"GO:0045188","count":2}]},{"hash":"1911065140284941079","title":"Cell Cycle and Chromosome Segregation","description":"The cluster is dominated by terms tied to cell cycle progression and chromosome maintenance: protein localization to the kinetochore, G1/S transition, DNA replication, and the meiotic cell cycle, which together point to mitotic/meiotic chromosome dynamics. Other terms like regulation of miRNA processing and inflammatory response, plus neural-related terms, appear less central, suggesting regulatory context rather than defining function. Overall, the core theme is cell cycle control and chromosome handling.","confidence":"Medium","size":15,"edges":41,"triangles":8,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":11},{"id":"GO:1903799","count":10},{"id":"GO:0050728","count":10},{"id":"GO:0051321","count":8},{"id":"GO:0000082","count":8}]},{"hash":"638982221710969340","title":"Brain Monoaminergic Signaling and Development","description":"This cluster is dominated by monoaminergic GPCR signaling (dopamine, octopamine/tyramine, norepinephrine) and brain-related processes (visual learning, cortical GABAergic interneuron migration), with cardiovascular regulation terms suggesting neural control of blood pressure. The presence of an electron transport chain term points to neuronal energy metabolism, and a cardiac morphogenesis term reflects developmental context. Overall, the week converges on neural signaling and brain development with supporting metabolism.","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":8},{"id":"GO:0031635","count":7},{"id":"GO:0008284","count":7},{"id":"GO:0002025","count":7},{"id":"GO:0022900","count":7}]},{"hash":"2041924216822536665","title":"ECM remodeling during development","description":"This cluster is enriched for terms involving extracellular matrix (ECM) degradation and remodeling (collagen catabolic process, basement membrane disassembly, bone resorption, intramembranous ossification) and developmental morphogenesis (lung branching), suggesting a coherent theme of ECM remodeling guiding tissue and organ development. Some listed terms are related to broader processes, but the dominant pattern points to matrix remodeling in developmental contexts.","confidence":"High","size":15,"edges":54,"triangles":107,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":7},{"id":"GO:0045453","count":7},{"id":"GO:0051603","count":7},{"id":"GO:0001913","count":7},{"id":"GO:0030574","count":7}]},{"hash":"734325258051888906","title":"Cholesterol metabolism and developmental morphogenesis","description":"This cluster shows strong cholesterol biosynthetic/metabolic signals (biosynthesis, metabolic process, efflux) alongside several developmental/morphogenesis terms (hair cycle, mammary gland duct morphogenesis, somite development, and growth regulation), suggesting a theme where cholesterol pathways intersect with tissue development and growth. Some terms (like visual learning) are peripheral, but the lipid-development link is the main thread.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":3},{"id":"GO:0006695","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0008285","count":2},{"id":"GO:0051436","count":2}]},{"hash":"969013887827904803","title":"Unknown","description":"The terms span disparate processes: intrinsic apoptotic signaling under oxidative stress, negative regulation of mitochondrial membrane potential, ER-Golgi trafficking, amyloid-beta metabolism, antibacterial peptide production, cGMP response, renin-angiotensin\u2013regulated aldosterone production, antigen processing via MHC II, and protein autoprocessing. This mix lacks a single, coherent functional theme, making a concise, representative label difficult.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008631","count":1},{"id":"GO:0002037","count":1},{"id":"GO:0010917","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0050435","count":1}]},{"hash":"1519035823933363994","title":"RNA processing and mRNA metabolism","description":"Top GO terms cluster around post-transcriptional RNA processing and mRNA metabolism (splicing, export, modification, and stability), indicating proteins involved in RNA maturation and translation regulation rather than transcription initiation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":4},{"id":"GO:1902625","count":3},{"id":"GO:0002188","count":3}]},{"hash":"1704499465570084093","title":"Metal Ion Transport and Homeostasis","description":"The top GO terms are dominated by ion transport and intracellular ion homeostasis, including magnesium, cadmium, zinc, calcium, and potassium transport across membranes. This suggests the proteins in this cluster primarily function to move or regulate ions rather than a single tissue-specific process, with some terms related to development or immune function as additional context. Overall, the shared theme is ion transport/homeostasis across membranes across different tissues.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0010961","count":3},{"id":"GO:0070574","count":3},{"id":"GO:0071577","count":3},{"id":"GO:0060037","count":3}]},{"hash":"1872285989118186576","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":36,"triangles":84,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0006412","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0009103","count":2},{"id":"GO:0009244","count":2}]},{"hash":"2297222529084867581","title":"Development and morphogenesis","description":"Reason: The top terms cluster around embryonic development, axis specification, morphogenesis of various tissues, and differentiation (e.g., dorsal/ventral axis, embryonic fin morphogenesis, heart and muscle differentiation, axon guidance). There are also related processes like proteolysis and nematode-specific molting, and even fertilization-related terms, suggesting a broad developmental biology theme rather than a single, specific pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0060468","count":4},{"id":"GO:0007313","count":4},{"id":"GO:0035124","count":4},{"id":"GO:0048632","count":4}]},{"hash":"1385683442853179424","title":"Unknown","description":"The top GO terms span chromatin-related processes (rDNA and subtelomeric heterochromatin formation), transcription elongation, various acetylation/post-translational modification events, and unrelated pathways (angiogenesis, melatonin and ectoine biosynthesis, glucosamine metabolism). Because there is no cohesive function tying all 15 proteins together, a single interpretable label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":3},{"id":"GO:0032968","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0019491","count":3},{"id":"GO:0030187","count":3}]},{"hash":"2256214062080187181","title":"Ion and small-molecule transmembrane transporters","description":"The top GO terms indicate broad transmembrane transport of ions (K+, Na+, phosphate, nitrite, nitrate) and small molecules (4-hydroxyphenylacetate, sialic acid, xenobiotics, vitamins), plus a note on neurotransmitter loading into synaptic vesicles, suggesting a cohesive group of membrane transport proteins with diverse substrates.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015706","count":2}]},{"hash":"108197129240126596","title":"Bacterial cell wall biosynthesis and glycosylation","description":"The top GO terms are dominated by biosynthetic processes related to the bacterial cell envelope and its glycoconjugates: peptidoglycan, lipoteichoic acid, glycolipids, and dolichol-linked oligosaccharides, along with broad carbohydrate metabolism. This pattern strongly suggests a cluster of proteins involved in constructing and modifying the cell wall/envelope rather than cytosolic processing, hence the chosen label. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":8},{"id":"GO:0070395","count":8},{"id":"GO:0008360","count":7},{"id":"GO:0030259","count":7},{"id":"GO:0009252","count":7}]},{"hash":"1849079719331437709","title":"Unknown","description":"The top GO terms span multiple unrelated biosynthetic pathways (lipopolysaccharide, O antigen, serine, heptose, antibiotic, anthocyanin) plus proteolysis, with a couple of highly specific, non-overlapping functions (paranode axon localization, prevention of polyspermy). This lack of a coherent, single biological theme suggests no meaningful shared function for the cluster, so an Unknown label is appropriate.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0009718","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0009243","count":3}]},{"hash":"2209658879524507588","title":"Vascular Regulation and Sensory Signaling","description":"Top GO terms point to vascular function (regulation of vascular permeability, vasodilation, blood pressure regulation) together with signaling pathways (GTPase activity regulation, membrane potential, opioid receptor signaling), plus thermosensory and nociceptive cues (temperature stimulus and pain perception). This pattern suggests a cluster of proteins involved in neurovascular signaling coordinating cardiovascular responses with thermo- and nociceptive signaling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043114","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0042391","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0019233","count":4}]},{"hash":"869770172233748387","title":"RTK-PI3K-AKT signaling with angiogenesis","description":"This cluster is enriched for GO terms tied to receptor tyrosine kinase autophosphorylation and PI3K/AKT signaling, including AKT activation and STAT tyrosine phosphorylation, plus angiogenesis and related developmental processes (Schwann cell and cardiac muscle proliferation). These share a common growth and vascular signaling theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071469","count":4},{"id":"GO:0060045","count":4},{"id":"GO:0090314","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0038083","count":4}]},{"hash":"1994697013459221031","title":"Cartilage development and ECM remodeling","description":"The top GO terms center on cartilage development, endochondral ossification, and collagen fibril organization/catabolism, along with integrin biosynthesis, highlighting extracellular matrix remodeling during cartilage formation. Some terms are broader (lipoprotein clearance, podocyte development), but the dominant signal is cartilage-related ECM remodeling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":5},{"id":"GO:0033034","count":5},{"id":"GO:0060351","count":5},{"id":"GO:0045112","count":5},{"id":"GO:0001958","count":5}]},{"hash":"475539074681831520","title":"Developmental Signaling and Stress Responses","description":"The top GO terms cluster around regulatory signaling and stimulus-responsive processes tied to development and tissue formation, including positive regulation of Wnt signaling, insulin signaling, heart development, and labyrinthine morphogenesis, plus responses to xenobiotics and prostaglandin signaling and ER stress\u2013related translation. This suggests a broad theme of developmentally linked signaling pathways and stress responses rather than a single, cohesive enzymatic function. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0060670","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0007507","count":2}]},{"hash":"2014111175844639718","title":"Transcriptional Regulation & Cell Cycle Control","description":"The top GO terms cluster around transcriptional regulation (DNA-templated transcription; RNA polymerase II/III preinitiation complex assembly; negative regulation of transcription) and cell cycle progression (G1/S and G2/M transitions). Regulators of signaling pathways (TGF-beta and insulin signaling) further tie gene expression to proliferation cues, supporting a cohesive theme of coordinated transcriptional control and cell-cycle regulation. Some terms (meiosis partner pairing, sumoylation) are more peripheral but do not erase the central connection. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014718","count":2},{"id":"GO:0033234","count":2},{"id":"GO:0007129","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1914534031837830986","title":"Neural signaling and ion transport","description":"This cluster centers on neural signaling and synaptic regulation, with terms for integrin signaling, long-term synaptic depression, Purkinje cell action potential depolarization, and various ion transports (potassium, manganese). Brain development and sensory pain detection terms further support a neural/brain function theme, tying the proteins to neuronal signaling and ionic homeostasis.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:1900454","count":1},{"id":"GO:0034651","count":1},{"id":"GO:0021759","count":1},{"id":"GO:0035024","count":1}]},{"hash":"1965056385279957213","title":"Fatty acid beta-oxidation and energy metabolism","description":"The cluster is dominated by GO terms related to fatty acid catabolism and beta-oxidation (medium- and long-chain fatty acids), along with related energy-management processes such as response to starvation and glycogen biosynthesis, indicating a theme of lipid-based energy production and carbohydrate storage/utilization. Some terms (e.g., cardiac muscle differentiation, obsolete aromatic compound catabolism) are less aligned, but do not override the main signal of metabolic energy pathways.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055007","count":2},{"id":"GO:0006574","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0051793","count":2},{"id":"GO:0005978","count":2}]},{"hash":"669745452382099493","title":"Glycinergic Neurotransmission","description":"The top GO terms emphasize glycine-mediated synaptic signaling and glycine secretion, with explicit glycinergic synaptic transmission. This suggests the proteins cluster around glycine-based neuronal signaling, rather than general RNA processing or other pathways. A few terms (dopamine/serotonin uptake, adenohypophysis development) are peripheral to the core theme, but do not override the main glycinergic signaling pattern.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0070651","count":2},{"id":"GO:1903346","count":1},{"id":"GO:0060092","count":1},{"id":"GO:0060012","count":1}]},{"hash":"1909674344987231053","title":"Diverse Substrate Transmembrane Transport","description":"The top GO terms indicate membrane transport across a wide range of substrates (sugars like arabinose and galactose, vitamins, nitrate and phosphate ions, sodium, xenobiotics, and 4-hydroxyphenylacetate) plus a vesicular transport role for neurotransmitter loading. This points to a cluster of membrane transport proteins with broad substrate specificity and a vesicular transport function, rather than a single-substrate pathway.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0015751","count":3},{"id":"GO:0015706","count":3}]},{"hash":"154387146780962684","title":"Cartilage and endochondral bone formation","description":"The cluster\u2019s top GO terms cluster strongly around cartilage development, endochondral ossification, and collagen fibril organization, with related adhesion and integrin biosynthesis processes, indicating a cohesive theme of skeletal extracellular matrix assembly and cartilage-to-bone formation. Some terms about lipoprotein clearance or podocyte development appear minor in this context.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2}]},{"hash":"2003354791010433297","title":"Fungal Innate Immune Response","description":"The top GO terms strongly point to innate antifungal signaling, including cellular response to molecule of fungal origin, basophil activation, and stimulatory C-type lectin receptor signaling, with negative regulation of NK cell chemotaxis also aligning with immune mobilization. A few terms related to metanephric kidney development and lymph vessel morphogenesis appear as outliers, likely annotation noise or pleiotropy. Since there are no edges or interactions in this cluster, the label reflects a shared immune response theme rather than a physical protein network.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":13},{"id":"GO:0045575","count":10},{"id":"GO:0072237","count":10},{"id":"GO:0036303","count":10},{"id":"GO:0072287","count":10}]},{"hash":"150283592068352838","title":"GPCR Signaling and Receptor Endocytosis","description":"The top GO terms cluster around GPCR signaling, endocytosis, and Rho/GTPase regulation, including positive regulation of Rho signaling, clathrin-dependent endocytosis, GPCR internalization, and adrenergic receptor\u2013related cAMP signaling. This points to a cohesive module of proteins involved in receptor trafficking and modulation of signal transduction, with ubiquitination potentially marking components for turnover; retina development appears ancillary to these core processes. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035025","count":2},{"id":"GO:0072583","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0002031","count":2},{"id":"GO:0016567","count":1}]},{"hash":"529416029011522438","title":"Thyroid Hormone Signaling in Development","description":"This cluster centers on thyroid hormone receptor signaling and its regulation, plus developmental processes (growth, prostate and gonad development). Immune and stress-related terms (lipopolysaccharide response, NF-kappaB regulation) suggest cross-talk between hormonal signaling and stress responses. Because the terms point to related but not tightly connected functions, the label reflects a developmental-hormone signaling theme with moderate confidence.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":14},{"id":"GO:0071222","count":13},{"id":"GO:0035264","count":13},{"id":"GO:0090340","count":13},{"id":"GO:0043124","count":13}]},{"hash":"97760147392444364","title":"Neuronal migration and axon guidance","description":"This cluster centers on neural development, with multiple terms for neuronal migration (neural crest, GnRH neuron migration) and axon guidance/extension (semaphorin-plexin signaling, axon extension). Sensory organ development terms (hair cell differentiation, retina morphogenesis) fit within broader neural development. Some terms like circadian regulation or retinal vasculature morphogenesis may reflect broader neurodevelopmental roles, but the dominant theme is neuronal migration and axon guidance.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":3},{"id":"GO:0045188","count":2},{"id":"GO:0061299","count":2},{"id":"GO:0002042","count":2},{"id":"GO:1902287","count":2}]},{"hash":"917151612007896341","title":"Neural signaling and sensory processing","description":"This cluster is enriched for neural communication and sensory-related GO terms: serotonin receptor signaling, dopamine secretion, histamine response, and general synaptic transmission, alongside sensory processing, cochlea development, conditioned taste aversion, and responses to amino acids. The collection points to neural signaling pathways tied to sensation and sensory processing.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0050893","count":2},{"id":"GO:2001226","count":2}]},{"hash":"484970503848883697","title":"Fucosylation-Glycosylation in Immune Regulation","description":"The top GO terms highlight fucose-containing glycosylation (Lewis a epitope biosynthesis, N-glycan fucosylation, general glycosylation) and immune-related processes (leukocyte migration, regulatory T cell differentiation). While a few terms touch on migration or neural contexts, the strongest signal is glycosylation, especially fucosylation, and its role in immune function, suggesting this cluster centers on fucose-containing glycoprotein biosynthesis and immune signaling.","confidence":"Medium","size":15,"edges":28,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":2},{"id":"GO:0036071","count":1},{"id":"GO:0002522","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0021799","count":1}]},{"hash":"1482852738251561359","title":"Cartilage and bone morphogenesis with ECM organization","description":"This cluster is dominated by terms related to cartilage development, endochondral ossification, collagen fibril organization, and integrin/ECM biosynthesis, pointing to a cohesive theme of extracellular matrix assembly and skeletal morphogenesis. Some terms (e.g., membrane depolarization) are less central and may reflect broader or overlapping functions, but the core signal supports ECM- and skeletal development processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060355","count":4},{"id":"GO:0051899","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3}]},{"hash":"959798395219583905","title":"Oocyte Meiosis and Spindle Dynamics","description":"The cluster is enriched for oocyte maturation, spindle assembly in female meiosis I, and microtubule polymerization, alongside SCF-dependent ubiquitin\u2013proteasome\u2013mediated protein degradation that regulates meiotic progression. While there are a couple of neural development terms, the dominant theme centers on meiosis, spindle dynamics, and protein turnover during gametogenesis.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006516","count":6},{"id":"GO:0046785","count":6},{"id":"GO:0021678","count":6},{"id":"GO:0021993","count":6},{"id":"GO:0070544","count":6}]},{"hash":"1568088612541349011","title":"Mitochondrial import, respiration, and mitophagy","description":"The top GO terms cluster around mitochondrial functions: import of proteins into the mitochondrial matrix, assembly of the respiratory chain complex II, autophagy/mitophagy of mitochondria, and regulation of cellular respiration. These collectively point to a mitochondria-centered role for the proteins, with translation and cell-cycle terms likely representing peripheral annotations. Therefore this label reflects the main functional theme of the cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0034553","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0010259","count":1},{"id":"GO:0000422","count":1}]},{"hash":"376959414731541506","title":"Serotonin-Dopamine Signaling in Sensory Processing","description":"This cluster shows strong enrichment for serotonin receptor signaling and dopamine secretion, plus sensory processing features (taste, hearing) and micturition-related synaptic transmission. It also includes ion transport terms reflecting neuronal excitability, and histamine- and taste-related responses. The common thread is neurosensory signaling mediated by multiple neurotransmitters.","confidence":"High","size":15,"edges":20,"triangles":9,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":14},{"id":"GO:0035725","count":14},{"id":"GO:0043200","count":14},{"id":"GO:0050893","count":14},{"id":"GO:2001226","count":14}]},{"hash":"1565033545270269274","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":1},{"id":"GO:0051259","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0032781","count":1}]},{"hash":"1358331233519105212","title":"Unknown","description":"The listed terms span translation initiation, splicing regulation, brain development, ncRNA-mediated silencing, viral mRNA export, cell proliferation, intraciliary transport, mitotic spindle assembly, and ubiquitin ligase regulation, with no connecting edges. This diversity suggests no single cohesive function for the cluster, so a meaningful, specific label cannot be assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0048025","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0031047","count":3}]},{"hash":"1353839187698945212","title":"Osteoclast differentiation and bone resorption","description":"This cluster shows strong enrichment for osteoclast differentiation and positive regulation of bone resorption, pointing to a bone remodeling/function in osteoclast activity. Other terms present (receptor internalization, transport, mitochondria-related processes, and some plant/fungal-specific terms) are more general or likely noise. The bone-related terms dominate, supporting this functional theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":2},{"id":"GO:0030316","count":2},{"id":"GO:0045780","count":2},{"id":"GO:0002814","count":2},{"id":"GO:0006120","count":2}]},{"hash":"2271130518250104317","title":"Unknown","description":"The listed GO terms are highly heterogeneous, ranging from ubiquitin-dependent ERAD and chromatin regulation to cholangiocyte proliferation, plant hormone biosynthesis, miRNA processing, NF-kappaB signaling, and vesicle transport, with no single biological theme tying them together. The cluster has no edges or interactions, suggesting it does not represent a coherent functional module, and several terms are obsolete, indicating potential annotation noise. Therefore, there is no clear, representative label beyond Unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0090055","count":2},{"id":"GO:1990705","count":2},{"id":"GO:0009190","count":2},{"id":"GO:0035196","count":2}]},{"hash":"380244639156677320","title":"Female meiosis spindle assembly and cell-cycle control","description":"This cluster is dominated by terms tied to oocyte maturation, spindle assembly in female meiosis I, microtubule dynamics, and ubiquitin-proteasome\u2013mediated protein degradation (SCF-dependent). Together they point to processes governing meiosis in oocytes and the broader cell-cycle regulation, despite a few more general developmental terms present. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":9},{"id":"GO:0046785","count":9},{"id":"GO:0021678","count":9},{"id":"GO:0021993","count":9},{"id":"GO:0070544","count":9}]},{"hash":"489713238309908741","title":"Diverse membrane solute transporters","description":"The top GO terms cluster around transmembrane transport for various substrates (Na+, K+, arabinose, nitrate, 4-hydroxyphenylacetate, vitamins, xenobiotics), suggesting a group of membrane transporter proteins with diverse specificities; transcription-related terms are present but less central, making transport the primary theme.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0016032","count":2}]},{"hash":"420754453952437531","title":"Lectin pathway\u2013driven innate immune activation","description":"Based on the top GO terms, the cluster centers on innate immune signaling and effector responses mediated by lectin pathways (complement activation via the lectin pathway, C-type lectin receptor signaling), basophil activation, and cellular responses to fungal origin, with additional regulation of NK cell chemotaxis. While a few development-related terms appear, the immune-related terms dominate, suggesting a cohesive theme around innate recognition and response to fungal components through lectin-mediated mechanisms.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0045575","count":5},{"id":"GO:0072237","count":5},{"id":"GO:0036303","count":5},{"id":"GO:0072287","count":5}]},{"hash":"842853540330590438","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0035690","count":2}]},{"hash":"540805597040563562","title":"Neurotransmitter signaling and cardiovascular regulation","description":"This cluster centers on multiple neurotransmitter signaling pathways (dopamine, octopamine/tyramine, opioid receptor signaling) plus vasodilation and blood pressure regulation terms, with additional hints of sensory detection and cardiac development. The common theme appears to be neural signaling linked to cardiovascular control.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050907","count":4},{"id":"GO:0031635","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0002025","count":3},{"id":"GO:0022900","count":3}]},{"hash":"1115284317125366961","title":"Cytoskeleton and polarity with lipid biosynthesis","description":"The dominant GO terms cluster around actin filament bundle assembly, cell migration, and establishment of epithelial cell polarity, which together point to cytoskeletal remodeling and polarized cell behavior. Ephrin receptor signaling also ties into cytoskeletal control and migration. The presence of lipid biosynthetic processes (phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol) supports membrane remodeling needed for polarity and movement. A couple of transcription-related terms appear but seem secondary. Overall, the cluster seems defined by cytoskeletal dynamics governing migration and epithelial polarity, in concert with membrane lipid synthesis.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":2},{"id":"GO:0048013","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2001438209374095065","title":"Dendrite development and neuronal polarity","description":"This cluster centers on neuronal morphology and signaling: dendrite development, Rho-mediated signal transduction, cell polarity related to cell shape, intraciliary transport, and neurotrophic responses, suggesting proteins involved in shaping neuronal processes and their polarized organization.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900740","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0035721","count":2},{"id":"GO:0008285","count":2}]},{"hash":"318543770672087825","title":"Oocyte Maturation and Meiotic Spindle Assembly","description":"The cluster is dominated by terms tied to oocyte development and meiotic processes, including oocyte maturation, spindle assembly in female meiosis I, and microtubule polymerization, as well as SCF-dependent proteasomal degradation\u2014together reflecting meiosis-specific regulation and chromosome segregation in oocytes. While some neural development terms appear, the strongest and most coherent signal centers on germ cell meiosis and maturation, suggesting a cohesive function in oogenesis and spindle dynamics.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":5},{"id":"GO:0046785","count":5},{"id":"GO:0021678","count":5},{"id":"GO:0021993","count":5},{"id":"GO:0070544","count":5}]},{"hash":"61102079431313875","title":"Olfactory sensory perception","description":"Dominant GO terms GO:0050907 and GO:0042048 indicate this cluster mainly collects proteins involved in detecting chemical stimuli and olfactory behavior. A few other signaling-related terms are present, but they do not redefine the core theme, which remains olfactory sensing.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":7},{"id":"GO:0042048","count":6},{"id":"GO:0007606","count":2},{"id":"GO:0031635","count":1},{"id":"GO:0008284","count":1}]},{"hash":"2052478147743168626","title":"Unknown","description":"The top GO terms cover immune response, multiple tissue development processes (retinal cone, mammary alveolus, Leydig cell differentiation, limb), transcriptional activity, and signaling regulation with no single cohesive function linking all proteins. There are no interactions among them (edges 0), so a specific, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0046549","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0060749","count":2},{"id":"GO:0033327","count":2}]},{"hash":"301137881165162945","title":"Cell Cycle and Lipid Metabolism Regulators","description":"The top GO terms show a mix of strong cell-division signals (cell division, mitotic cell cycle, cell population proliferation) and several lipid metabolism/handling processes (lipid storage, intracellular triglyceride homeostasis, diacylglycerol biosynthetic, long-chain fatty-acyl-CoA metabolism, LDL particle clearance). This pattern suggests a group of proteins that may coordinate cell proliferation with lipid metabolism. However, the connection is not overwhelmingly dense, so the label is plausible but not definitive.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0071400","count":1}]},{"hash":"932304600157506384","title":"Integrin signaling and ECM remodeling","description":"The top GO terms cluster around integrin-mediated signaling, cell-matrix adhesion, ECM assembly and remodeling, and cell migration, indicating proteins involved in adhesion to the extracellular matrix and ECM dynamics. Supporting terms point to protein turnover (proteasome assembly, ubiquitin-dependent catabolism). Immune/vascular contexts (T cell activation, blood coagulation) may reflect broader connectivity to these pathways, while an unrelated chlorophyll biosynthesis term likely represents noise. Thus, the core theme is integrin signaling coupled with ECM remodeling.","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0043248","count":2},{"id":"GO:0006929","count":2},{"id":"GO:0070208","count":2},{"id":"GO:1901202","count":2}]},{"hash":"274798206334793133","title":"Nematode development and egg-laying behavior","description":"The terms point to nematode-specific development and behavior, including egg-laying regulation, larval locomotion, molting, and pharyngeal pumping, suggesting a cluster of genes involved in nematode development and reproductive/behavioral processes rather than a single enzymatic function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045434","count":1},{"id":"GO:0048042","count":1},{"id":"GO:0002209","count":1},{"id":"GO:1901045","count":1},{"id":"GO:0008345","count":1}]},{"hash":"1200220664416695968","title":"Cerebellar development and glial differentiation","description":"This cluster is best described by cerebellar-focused neural development signals: cerebellar cortex formation and Bergmann glial cell differentiation appear prominently (GO:0021697 and GO:0060020), alongside related neural processes such as regulation of axon regeneration. The involvement of ERK/MAPK pathway regulation and insulin signaling hints supportively toward neural development and glial maturation. Some terms (e.g., T cell signaling) are less coherent with cerebellar biology, suggesting partial overlap or broader signaling roles, but the strongest evidence centers on cerebellar development and glial differentiation.","confidence":"Medium","size":14,"edges":29,"triangles":26,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000200","count":10},{"id":"GO:0050860","count":10},{"id":"GO:0070373","count":10},{"id":"GO:2001275","count":9},{"id":"GO:0008285","count":9}]},{"hash":"43522028855330364","title":"Cardiac morphogenesis and valve development","description":"The top GO terms cluster around heart development, including cardiac ventricle morphogenesis and pulmonary valve morphogenesis, with related angiogenesis regulation, suggesting a cohesive cardiac morphogenesis theme. Some terms appear peripheral (e.g., response to cocaine, sensory cell fate), but the dominant signal is heart development.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0009912","count":1},{"id":"GO:0060528","count":1},{"id":"GO:0072137","count":1},{"id":"GO:0003208","count":1}]},{"hash":"1423571219729683977","title":"Cardiovascular GPCR Signaling","description":"This cluster is anchored by GPCR signaling pathways that inhibit adenylate cyclase (opioid and dopamine receptor signaling) and octopamine/tyramine signaling, with terms tied to vasodilation and blood pressure regulation (norepinephrine-epinephrine- and angiotensin-mediated). Cardiac muscle growth and lung connective tissue development hint at cardiovascular development, supporting a cardiovascular signaling theme, while other terms (electron transport, interneuron migration) are less central. ","confidence":"Medium","size":14,"edges":17,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0031635","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0002025","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0021853","count":2}]},{"hash":"2127841128722426660","title":"Developmental Regulation and Stress Response","description":"The top GO terms point to broad developmental processes (forebrain development, skeletal system development, male gonad development, multicellular organism development) and a central role in transcription (DNA-templated transcription), plus cellular stress and immune aspects (response to cadmium, ER-stress\u2013induced apoptosis, defense against Gram-positive bacteria). This suggests a cluster of proteins involved in regulating development while coordinating transcriptional programs and stress responses, rather than a single narrow function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1200499092906335474","title":"Tissue Development and Morphogenesis","description":"This cluster is dominated by GO terms tied to development and morphogenesis across tissues\u2014multicellular organism development, skin development, and morphogenesis of metanephric tubules and lymph vessels\u2014pointing to a general developmental/morphogenetic theme. Some terms (immune signaling, ubiquitin-related ERAD, GTPase regulation) are peripheral, suggesting annotation noise or broader functional roles. Overall, a developmental/tissue morphogenesis label fits best.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007275","count":2}]},{"hash":"988085687291069587","title":"Chitin-based cuticle development and molting","description":"Most terms point to chitin-based cuticle biology, including cuticle development, chitin catabolic processes, and ecdysis, which together define a cohesive theme of arthropod cuticle formation and molting. A few terms about cytokine responses and other developmental processes are present but far less represented, making them secondary to the core function.","confidence":"High","size":14,"edges":72,"triangles":182,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0070741","count":1},{"id":"GO:0030324","count":1}]},{"hash":"932987499432660137","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010923","count":2},{"id":"GO:1901750","count":1},{"id":"GO:0006751","count":1},{"id":"GO:0006750","count":1},{"id":"GO:0006508","count":1}]},{"hash":"652069152979113774","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032007","count":2},{"id":"GO:0048254","count":1},{"id":"GO:0006356","count":1},{"id":"GO:0031167","count":1},{"id":"GO:1990258","count":1}]},{"hash":"1247640976679004090","title":"Potassium Transport and Membrane Potential Regulation","description":"This cluster is dominated by GO terms related to potassium ion movement across membranes (import, export, transmembrane transport) and intracellular potassium ion homeostasis, plus membrane hyperpolarization, which together point to regulation of membrane potential via potassium flux. The presence of protein homooligomerization supports the idea of channel subunits forming functional potassium channels. Some terms about skin development and thermogenesis may reflect tissue-specific contexts or indirect associations, but the core signal is potassium handling and membrane potential control.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":6},{"id":"GO:0060081","count":6},{"id":"GO:1990573","count":6},{"id":"GO:0097623","count":6},{"id":"GO:0071805","count":5}]},{"hash":"2010650939556692608","title":"Vertebrate neural and gonadal development","description":"The top GO terms cluster around brain/retina/spinal cord development and male gonad development, plus general multicellular organism development and fertilization, indicating a coherent theme of vertebrate neurodevelopment and reproductive organ formation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007018","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0043981","count":2}]},{"hash":"1389769071413241865","title":"Unknown","description":"The top GO terms point to neural development and synaptic signaling, plus a few unrelated processes (platelet-related, pigment/antibiotic biosynthesis), with no single cohesive function linking all proteins. Because there is no clear shared theme that unifies these terms into a specific, informative cluster label, I cannot assign a representative name beyond Unknown.","confidence":"","size":14,"edges":10,"triangles":0,"max_degree":4,"top_function":"wound healing","top_go_terms":[{"id":"GO:0070527","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0097477","count":5},{"id":"GO:0009718","count":4},{"id":"GO:0017000","count":4}]},{"hash":"567687816704645134","title":"Steroid hormone and prostaglandin biosynthesis","description":"This cluster is dominated by GO terms for the biosynthesis of steroid hormones (cortisol, testosterone, aldosterone, progesterone) and prostaglandins, indicating a coherent theme around lipid hormone production. The inclusion of an anti-inflammatory regulation term fits steroids\u2019 known roles in dampening inflammation, supporting the theme. A couple of terms (insecticide metabolic process, vancomycin biosynthesis) appear as noise, but do not overturn the core connection to steroid and prostaglandin pathways.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":8},{"id":"GO:0033072","count":5},{"id":"GO:0034651","count":5},{"id":"GO:0061370","count":5},{"id":"GO:0032342","count":5}]},{"hash":"200565022872930645","title":"Coagulation and Fibrinolysis Regulation","description":"The top GO terms cluster around coagulation and fibrinolytic pathways (blood coagulation, fibrinolysis, regulation of plasminogen activation, bradykinin catabolic process) and extracellular matrix remodeling (ECM constituent secretion), suggesting a function in proteolytic regulation of hemostasis and tissue remodeling. Some terms related to tissue regeneration and proteolytic processing appear ancillary, but the core theme points to coagulation/fibrinolysis interactions with ECM turnover.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":3},{"id":"GO:0003331","count":3},{"id":"GO:0010757","count":3},{"id":"GO:0021702","count":3},{"id":"GO:0097421","count":3}]},{"hash":"2134532415672458642","title":"Embryonic and Organ Morphogenesis","description":"The top GO terms cluster around developmental and morphogenetic processes across multiple tissues (gonad, hindlimb, eye, placenta, prostate, pituitary, habenula), suggesting the proteins are broadly involved in embryonic tissue development and organ morphogenesis rather than a single pathway. A lone transcriptional regulator term is present but not central to the theme, so the label focuses on morphogenesis across organs.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":8},{"id":"GO:0003148","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0035116","count":7},{"id":"GO:0000122","count":7}]},{"hash":"1968915767706547023","title":"Neural development and immune signaling","description":"The most represented terms include neural development processes (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration), together with immune-related signaling (T cell receptor signaling, response to lipopolysaccharide) and metabolic/vascular cues (insulin signaling, angiogenesis). The common thread is signaling events that coordinate neural development with immune and vascular responses.","confidence":"Medium","size":14,"edges":8,"triangles":0,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":13},{"id":"GO:0046827","count":13},{"id":"GO:0008285","count":13},{"id":"GO:0021697","count":13},{"id":"GO:0008286","count":13}]},{"hash":"1929921552561374327","title":"Cerebellar development and synaptic formation","description":"The dominant GO terms point to cerebellar cortex formation, Bergmann glial cell differentiation, and dendritic spine morphogenesis, with related processes like axon regeneration and insulin signaling. This combination suggests a module focused on cerebellar neuron development and synapse organization rather than a purely metabolic or immune function. Some terms may be broader or incidental.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":12},{"id":"GO:0008285","count":12},{"id":"GO:0021697","count":12},{"id":"GO:0008286","count":12},{"id":"GO:0048679","count":12}]},{"hash":"862746854655162819","title":"Ribosome Biogenesis and Translation","description":"Most terms point to ribosome function and mRNA translation (translation, cytoplasmic translation, ribosome biogenesis, ribosomal subunit assembly) with additional related terms like translational fidelity regulation and selenocysteine incorporation. This aligns with a cluster of proteins involved in ribosome assembly and protein synthesis rather than other processes.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0000027","count":2}]},{"hash":"464086450810873476","title":"Ion transport and cellular ion homeostasis","description":"The top GO terms cluster around membrane transport and homeostasis of ions, notably potassium and sodium, including K+ and Na+ export/import, intracellular K+ homeostasis, and cell volume homeostasis, along with related stress responses (salt stress, methylglyoxal) and vacuolar acidification. This points to a coherent theme of maintaining ionic balance and cellular/osmotic regulation, with a few peripheral terms such as sensory perception and cardiac conduction as less central noise. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":2},{"id":"GO:0097623","count":1},{"id":"GO:0007035","count":1},{"id":"GO:0086092","count":1},{"id":"GO:0009651","count":1}]},{"hash":"531472539838615737","title":"Amino Acid Metabolism Cluster","description":"The top GO terms are dominated by amino acid\u2013related processes (lysine, alanine, aspartate, tyrosine biosynthesis/catabolism) and related pathways (cobalamin and kynurenic acid biosynthesis), suggesting a shared focus on amino acid metabolism. Outliers like DNA-templated transcription and Notch signaling appear peripheral, but the central theme aligns with amino acid biosynthesis and turnover.","confidence":"Medium","size":14,"edges":32,"triangles":17,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033512","count":6},{"id":"GO:0019878","count":5},{"id":"GO:0007219","count":4},{"id":"GO:0042853","count":4},{"id":"GO:0009236","count":4}]},{"hash":"1506393647302988125","title":"Symbiont-Mediated Immune Modulation","description":"The top GO terms cluster around host\u2013symbiont interactions that modulate adaptive immunity, including MHC class II\u2013mediated antigen processing/presentation, regulation of tolerance, and suppression of the host immune response, along with symbiont-driven perturbation of ubiquitin-like protein modification. Some terms (transcription, cutin/suberin biosynthesis) appear less tightly linked, likely reflecting broader biological roles or annotation noise, but the core signal points to immune modulation by symbionts.","confidence":"Medium","size":14,"edges":34,"triangles":26,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0045347","count":2},{"id":"GO:1900490","count":2},{"id":"GO:0039648","count":2},{"id":"GO:0010143","count":2}]},{"hash":"1484444708250287275","title":"Axon guidance and neural crest migration","description":"Based on the GO terms, the proteins cluster around neural development, particularly axon guidance (axonogenesis, axon extension) and neural crest cell migration, with supportive terms for autonomic nervous system development and neuromast differentiation. The scattered single-term enrichments suggest a broader nervous-system\u2013related program, but the common thread is neural pathfinding and migration.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061299","count":1},{"id":"GO:0002042","count":1},{"id":"GO:1902287","count":1},{"id":"GO:1901166","count":1},{"id":"GO:0048846","count":1}]},{"hash":"1966246191035720632","title":"Cerebellar development and Bergmann glial differentiation","description":"The top GO terms point to cerebellar biology, with cerebellar cortex formation and Bergmann glial cell differentiation being prominent, suggesting a neural development theme centered on the cerebellum and its glial components. Other terms about axon regeneration and insulin signaling appear, but the cerebellar development signals are most distinctive. Thus, a label focusing on cerebellar development and Bergmann glial differentiation best captures the cluster\u2019s core function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":7},{"id":"GO:0060336","count":6},{"id":"GO:0048679","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0060020","count":5}]},{"hash":"1954266447272047348","title":"Wnt and Hippo Signaling in Development","description":"The enriched terms cluster around development and growth regulation, notably canonical Wnt signaling and Hippo signaling, plus broader development (multicellular development, hippocampus development) and apoptosis. This suggests proteins that coordinate signaling pathways controlling development and cell fate, with some overlap into differentiation processes like keratinocyte differentiation, while other terms (pain, potassium transport) may reflect broader cellular roles in these proteins.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":5},{"id":"GO:0035329","count":4},{"id":"GO:0060044","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0030216","count":4}]},{"hash":"616094276764729695","title":"T cell receptor signaling and development","description":"The Top Terms center on T cell biology and related signaling cascades: T cell receptor signaling pathway, beta selection (thymic T cell development), and positive regulation of ERK1/2 cascade (MAPK pathway downstream of TCR). Additional terms like ephrin receptor signaling and canonical Wnt signaling also tie into thymic development and T cell maturation, while cellular response to virus reflects immune-related transcriptional responses. Despite some obsolete terms, the common theme across the cluster is immune signaling leading to transcriptional changes in T cells.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0090263","count":3}]},{"hash":"999308687037155684","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":4},{"id":"GO:0000447","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0070208","count":3},{"id":"GO:0046784","count":2}]},{"hash":"1964819121725731547","title":"Unknown","description":"The top GO terms span both kidney development (metanephric proximal/distal tubule morphogenesis, ascending limb development) and various immune/antigen-presenting processes (basophil activation, C-type lectin receptor signaling, NK cell chemotaxis, response to fungal origin), with no single cohesive biological function tying all terms together. Therefore a specific label is not justifiable; label is Unknown with no confidence.","confidence":"","size":14,"edges":12,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":5},{"id":"GO:0072237","count":5},{"id":"GO:0036303","count":5},{"id":"GO:0072287","count":5},{"id":"GO:0002223","count":5}]},{"hash":"504584093628487665","title":"Muscle contraction and filament sliding","description":"The cluster is dominated by GO terms related to muscle function: cardiac muscle contraction, smooth muscle contraction, muscle filament sliding, regulation of filament sliding speed, and regulation of ATP-dependent activity. These point to a common theme of muscle contraction machinery and fiber dynamics. The few outlier terms (cellular response to CO2, carbon utilization, stomatal development) may reflect multi-functional proteins or cross-species annotations, but do not override the central muscle-related signal. ","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071244","count":1},{"id":"GO:0015976","count":1},{"id":"GO:2000122","count":1},{"id":"GO:0006942","count":1},{"id":"GO:0014883","count":1}]},{"hash":"10614128992370337","title":"TGF-beta/SMAD signaling regulation","description":"Based on the GO terms, the cluster centers on transforming growth factor beta (TGF-\u03b2) signaling and SMAD-related regulation, including cellular responses to TGF-\u03b2 and negative regulation of SMAD complex assembly and TGF-\u03b2 receptor signaling. There is also a pattern of phosphorylation-related terms (dephosphorylation and phosphorelay), suggesting modulation of signal transduction, though a few terms like translation and photosystem stoichiometry adjustment appear less connected and may reflect annotation noise.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0035970","count":1},{"id":"GO:0042006","count":1},{"id":"GO:0080005","count":1},{"id":"GO:0006470","count":1}]},{"hash":"499404798101954400","title":"Transcription and ubiquitin-mediated proteolysis","description":"Based on the top terms, the strongest shared functions are DNA-templated transcription and ubiquitin-dependent protein catabolic process, pointing to a focus on regulation of gene expression and protein turnover. Other terms touch on growth, membrane-associated processes, and metabolism but do not dominate, so the core theme remains transcriptional regulation plus proteolysis.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0010216","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0019290","count":1}]},{"hash":"1828300074044609394","title":"Mammalian tissue differentiation and morphogenesis","description":"The terms center on differentiation of muscle and placental/m mammary tissues (myoblast differentiation, trophoblast giant cell differentiation, mammary duct growth) and processes like tube lumen formation, all hallmark features of tissue morphogenesis in mammals. Supporting terms on signaling regulation, apoptosis, and immune cell chemotaxis align with remodeling and developmental signaling during tissue formation. Overall, the cluster points to mammalian tissue differentiation and morphogenesis.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045445","count":2},{"id":"GO:1903133","count":2},{"id":"GO:0052182","count":2},{"id":"GO:0042730","count":2},{"id":"GO:0010758","count":2}]},{"hash":"2010573405561159822","title":"Photoreceptor GPCR Signaling and Retinal Maintenance","description":"This cluster centers on GO terms related to retina development, visual perception, photoreceptor maintenance, and GPCR signaling (including GPCR internalization and arrestin-associated desensitization) with links to GTPase activity and ERK signaling, suggesting proteins involved in phototransduction and retinal cell maintenance. A few terms (e.g., viral release, deprecated annotations) are noise relative to the core retinal GPCR signaling theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0035025","count":3},{"id":"GO:0002032","count":3},{"id":"GO:0070374","count":3}]},{"hash":"1059399046181658303","title":"Adipogenesis and NF-kappaB\u2013mediated immune signaling","description":"Fat cell differentiation is a prominent signal, along with cellular responses to lipopolysaccharide and regulation of canonical NF-kappaB signaling, pointing to a cluster where adipocyte development intersects immune/inflammatory pathways. The presence of transcription-related terms and growth suggests a broader regulatory role in development, but the combination of adipogenesis with NF-kappaB\u2013linked immune signaling best characterizes the cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0010745","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0017000","count":2}]},{"hash":"589553830451976075","title":"Diverse signaling and developmental processes","description":"The top GO terms span ubiquitination, mechanical stimulus response, developmental events (notochord formation, osteoclast differentiation, sprouting angiogenesis), immune cell proliferation, and signaling responses (forskolin). This suggests a broad set of signaling and differentiation roles across tissues rather than a single cohesive pathway, especially given there are no observed edges. Therefore a high-level label capturing multiple signaling and developmental processes is appropriate.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0002042","count":1},{"id":"GO:0010839","count":1},{"id":"GO:0007628","count":1}]},{"hash":"362364985085520744","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0002188","count":2},{"id":"GO:1901976","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0000472","count":2}]},{"hash":"277961888796619521","title":"Endosomal-Lysosomal Trafficking and Degradation","description":"These proteins cluster around intracellular trafficking routes that move receptors through endosomes to lysosomes, including endosome-to-melanosome transport and lysosomal protein localization, as well as proteolytic processes within vacuoles. The overlap of receptor internalization, endosomal transport, and lysosome-associated degradation supports a cohesive theme of endosomal-lysosomal trafficking and protein turnover.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":2},{"id":"GO:0035646","count":1},{"id":"GO:0007601","count":1},{"id":"GO:0030886","count":1},{"id":"GO:1900746","count":1}]},{"hash":"562946916462269876","title":"Glycerophospholipid Remodeling & Cardiolipin Biosynthesis","description":"The cluster is dominated by lipid metabolism and membrane lipid remodeling terms, including phosphatidylcholine acyl-chain remodeling, ether lipid biosynthesis, cardiolipin remodeling, platelet activating factor biosynthesis, and CDP-diacylglycerol biosynthesis, with a note of mitochondrial ATP synthesis context. While a couple terms touch immune signaling and glandular maturation, the strongest signal is lipid biosynthesis and mitochondrial membrane lipid remodeling, suggesting a common function in membrane lipid dynamics. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002071","count":4},{"id":"GO:0010143","count":4},{"id":"GO:0016024","count":4},{"id":"GO:0042775","count":4},{"id":"GO:0008611","count":4}]},{"hash":"795494173257155705","title":"Neuronal Cytoskeleton and Polarity","description":"The cluster\u2019s top GO terms are dominated by actin cytoskeleton organization, dendrite development, receptor clustering, and polarity establishment (including epithelial and planar polarity in neural contexts), pointing to cytoskeletal remodeling and cell polarity processes in neural cells. Some terms (proteolysis, protein localization) are broader, but the prevailing signal ties to neuronal cytoskeleton dynamics and polarity. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030036","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0030163","count":2},{"id":"GO:0090179","count":1},{"id":"GO:0035750","count":1}]},{"hash":"438183226608518987","title":"Glomerular epithelial cell differentiation","description":"The GO terms show clear emphasis on differentiation and maintenance of renal glomerular epithelium, including podocytes and glomerular/parietal epithelial cells, with supporting mentions of nephron tubule epithelial differentiation. Although there are a few non-kidney terms in the mix (endocytosis regulation, oxidative stress, etc.), the strongest and most coherent signal centers on kidney glomerular epithelium development, making this a concise and representative label.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048550","count":1},{"id":"GO:0072112","count":1},{"id":"GO:2000768","count":1},{"id":"GO:0072139","count":1},{"id":"GO:2001287","count":1}]},{"hash":"1532812777319457833","title":"Neural development and synaptic signaling","description":"The cluster shows strong signals in nervous system development, regulation of synapse structure/activity, and ionotropic glutamate receptor signaling, plus axon guidance and collateral sprouting, pointing to roles in neural circuit formation and synaptic function. Some terms (blood coagulation, amyloid fibril formation) are less central, but the dominant theme is neuronal development and synaptic regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0035235","count":1},{"id":"GO:0060670","count":1},{"id":"GO:0050803","count":1}]},{"hash":"1102800032493512398","title":"Unknown","description":"The top GO terms span neural signaling, cardiac membrane dynamics, cytoskeletal organization, and signaling pathways with no single unifying function. This heterogeneous mix makes it impossible to assign a cohesive, specific functional label to this cluster, so the appropriate designation is Unknown with no confidence.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902260","count":1},{"id":"GO:1900454","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0060081","count":1},{"id":"GO:0043149","count":1}]},{"hash":"2283492268579902483","title":"Unknown","description":"The GO terms span diverse processes (pigmentation development, megakaryocyte development, neutrophil degranulation, lipopolysaccharide response, angiogenesis, dendritic cell cytokine production, salivary gland boundary specification, atrial cardiomyocyte action potential, axon guidance, and STAT signaling), with no clear single functional theme linking the proteins. The lack of edges also suggests no cohesive interaction pattern. Therefore a unified, specific label is not supported; Unknown is appropriate. ","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048070","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0043312","count":2},{"id":"GO:0071222","count":1},{"id":"GO:0001525","count":1}]},{"hash":"1330543972475276410","title":"Cerebellar Cortex Development and Bergmann Glia Differentiation","description":"The cluster prominently features GO terms tied to cerebellar cortex formation and Bergmann glial cell differentiation (GO:0021697, GO:0060020), with supporting links to axon regeneration and cytoskeletal/kinetochore localization (GO:0048679, GO:0035372, GO:0034501). This points to a neural development theme centered on the cerebellum and its glial components, despite some ancillary immune-related terms present. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008285","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0035372","count":5},{"id":"GO:0048679","count":5}]},{"hash":"1116500237771580392","title":"Multi-tissue developmental signaling","description":"The top GO terms span nervous system development (including hippocampus), kidney development, and bone-related processes (ossification, bone resorption), plus signaling pathways like Hedgehog (Smoothened) and axon guidance (Roundabout). This suggests a shared theme of developmental signaling across tissues, with neural maturation elements such as synaptic vesicle exocytosis.","confidence":"Medium","size":13,"edges":58,"triangles":117,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0001822","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0035385","count":6}]},{"hash":"1557524297872143637","title":"Cartilage formation and ECM remodeling","description":"The cluster shows strong representation of cartilage development and endochondral ossification, plus collagen fibril organization and collagen catabolic processes, all pointing to extracellular matrix (ECM) assembly/remodeling during skeletal formation. Integrin biosynthesis aligns with ECM interactions, reinforcing the theme. A few terms (lipoprotein clearance, PDGF signaling) are less central but do not outweigh the core cartilage/ECM signal.","confidence":"High","size":13,"edges":25,"triangles":0,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":4},{"id":"GO:0033034","count":4},{"id":"GO:0060351","count":4},{"id":"GO:0045112","count":4},{"id":"GO:0001958","count":4}]},{"hash":"1831954704310164856","title":"Calcium-NFAT signaling and T cell differentiation","description":"This cluster centers on calcium signaling and NFAT-mediated transcription, with terms like release of sequestered calcium, regulation of the calcineurin-NFAT signaling cascade, and regulation of T cell differentiation in thymus. The presence of related transcriptional processes (RNA Pol II termination/processing) and apoptosis suggests NFAT-regulated transcription and cell fate decisions in immune cells as downstream themes, making Calcium-NFAT signaling the most representative core.","confidence":"High","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042769","count":1},{"id":"GO:0006379","count":1},{"id":"GO:0051533","count":1},{"id":"GO:0070940","count":1},{"id":"GO:0010526","count":1}]},{"hash":"2210819172131845300","title":"Embryonic organogenesis and TGF-beta signaling","description":"Based on the top GO terms, the proteins cluster around developmental processes such as metanephric kidney development, blastocyst formation, and endocardial cushion EMT, as well as cell-matrix adhesion and vascular development, all of which are morphogenetic events in embryogenesis. The presence of TGF-beta receptor complex assembly further suggests a shared signaling axis governing these organogenesis-related processes. Immune terms are present but less cohesive with the core developmental theme, and may reflect secondary roles or incidental connections. Overall, the cluster seems best described as embryonic organogenesis guided by TGF-beta signaling.","confidence":"Medium","size":13,"edges":20,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0072233","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0002455","count":1},{"id":"GO:0072221","count":1},{"id":"GO:0007181","count":1}]},{"hash":"1581126142064179460","title":"DNA maintenance and ribosome biogenesis in development","description":"This cluster centers on core cellular maintenance: DNA replication, DNA repair, and DNA damage tolerance, complemented by ribosome biogenesis (maturation of SSU-rRNA and translation). The inclusion of embryonic cranial skeleton morphogenesis suggests a developmental context where genome maintenance and protein synthesis are crucial. Peripheral terms like innate immune response and synaptic plasticity may reflect broader roles or pleiotropy but do not override the main theme of genome maintenance and ribosome biogenesis in development.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0031914","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0006301","count":2}]},{"hash":"180843076951077660","title":"Developmental processes and chromatin assembly","description":"This cluster is driven by multiple developmental GO terms (ovarian follicle development, brain development, spermatogenesis, spermatid development), suggesting a theme of developmental biology. While there are also terms tied to chromatin assembly and DNA replication, which relate to cell division during development, the prominent signal is development. Some metabolic terms appear, but they are less central to the cluster\u2019s core theme. Therefore, a label focusing on development with a nod to chromatin/DNA processes best captures the common thread.","confidence":"Medium","size":13,"edges":40,"triangles":29,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001541","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0061641","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0006260","count":2}]},{"hash":"634006218225980487","title":"Ribosome Biogenesis and Translation","description":"The cluster is strongly enriched for protein synthesis and ribosome-related processes: translation, ribosome biogenesis, translational initiation, and export of the ribosomal subunit from the nucleus, plus mitochondrial translation. The presence of mitochondrial-specific activities (lipoylation, glycine decarboxylation via the glycine cleavage system) suggests a link between mitochondrial metabolism and ribosome/translation machinery, fitting a theme of coordinated ribosome biogenesis and protein synthesis across cellular compartments, often tied to cell growth/division.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0009249","count":1},{"id":"GO:0019464","count":1}]},{"hash":"889440828926389148","title":"Diverse Substrate Membrane Transporters","description":"The top GO terms point to transmembrane transport of a wide range of substrates\u2014vitamins, xenobiotics, ions, sugars, and other metabolites\u2014indicating a cluster of membrane transporter proteins with broad substrate specificity. Confidence is high that this label captures the common function of the proteins in the cluster.","confidence":"High","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":9},{"id":"GO:0006855","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0035725","count":9},{"id":"GO:0042908","count":8}]},{"hash":"1702074721765869970","title":"Embryonic Development and Immune-Stress Regulation","description":"The proteins appear linked to developmental programs (in utero embryonic development, neuron maturation, multicellular growth) and transcriptional control, while also connecting to stress and immune signaling (response to immobilization stress, LPS response, and regulation of NF-kappaB). This suggests a cluster that integrates developmental processes with immune/stress signaling pathways.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":9},{"id":"GO:0006351","count":7},{"id":"GO:0001701","count":7},{"id":"GO:0042551","count":7},{"id":"GO:0071222","count":6}]},{"hash":"2037284720619579822","title":"Neuronal development and synaptic signaling","description":"Based on the dominant GO terms, the cluster is centered on neural development (axonogenesis, Schwann cell development) and synaptic function (long-term potentiation, excitatory postsynaptic potential, visual perception). Although cell-cycle terms appear, the prevailing theme is neuronal differentiation and synaptic activity, so a label combining neural development with synaptic signaling is appropriate.","confidence":"High","size":13,"edges":9,"triangles":5,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007409","count":8},{"id":"GO:0060291","count":8},{"id":"GO:0014044","count":8},{"id":"GO:0000086","count":8},{"id":"GO:0010800","count":8}]},{"hash":"1729850160909577981","title":"Neural development and actin cytoskeleton remodeling","description":"The terms cluster around neural development and actin dynamics\u2014neuroblast proliferation, dendritic spine morphogenesis, lamellipodium/actin filament assembly, and oligodendrocyte development\u2014consistent with neurite outgrowth and synaptic remodeling. A few terms (thymus development, regulation of ubiquitination) are less directly connected but do not negate the main theme.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002052","count":2},{"id":"GO:0048538","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0014003","count":2},{"id":"GO:0030036","count":2}]},{"hash":"1783004310210170872","title":"Immune and Hormone Signaling Regulators","description":"This cluster centers on regulatory processes across immune (lipopolysaccharide response; NF-kappaB signaling) and endocrine (thyroid hormone receptor signaling; regulation of thyroid signaling) pathways, with additional notes on secretion and development, suggesting a theme of broad signaling modulation rather than a single pathway. Confidence is medium due to the mixed GO terms spanning distinct systems, though a general regulatory theme is evident.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":7},{"id":"GO:0035264","count":7},{"id":"GO:2001275","count":7},{"id":"GO:0090340","count":7},{"id":"GO:0043124","count":7}]},{"hash":"1982217244330589455","title":"Kidney tubule morphogenesis with innate immunity","description":"This cluster is anchored by multiple metanephric development terms (proximal/distal tubule morphogenesis, ascending limb development), pointing to kidney nephron morphogenesis. At the same time, immune-related terms (basophil activation, C-type lectin receptor signaling, fungal-origin response) suggest concurrent innate immune signaling. The combination implies a primary connection to kidney development with some immune signaling representation.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":6},{"id":"GO:0072237","count":6},{"id":"GO:0036303","count":6},{"id":"GO:0072287","count":6},{"id":"GO:0002223","count":6}]},{"hash":"842463266702499775","title":"mRNA capping and RNA processing","description":"The top GO terms cluster around RNA maturation, notably 7-methylguanosine mRNA capping and pre-mRNA cleavage/polyadenylation, plus regulation of mRNA cap binding. These indicate a shared function in RNA processing and maturation. Some other terms (drug response, energy homeostasis) appear less cohesive with this core theme, so the label reflects the main signal with moderate confidence.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0098789","count":2}]},{"hash":"1728733177936366985","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000747","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000472","count":2}]},{"hash":"1810368675545411878","title":"Bacterial central metabolism and LPS biosynthesis","description":"It combines strong signals for core metabolism (glycolytic process, TCA cycle, 2-oxoglutarate metabolic process) with envelope-related biosynthesis (O antigen/LPS, dTDP-rhamnose biosynthesis, cell wall organization, extracellular polysaccharide biosynthetic process), suggesting a cluster of proteins involved in energy metabolism linked to lipopolysaccharide and cell wall assembly in bacteria. Some annotations like mitochondrial translation are odd for bacteria, but the overall theme remains coherent around metabolism and envelope biosynthesis.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0032543","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0006103","count":3},{"id":"GO:0006099","count":3}]},{"hash":"976361735983400937","title":"ER-mitochondria tethering and neuronal plasticity","description":"The terms cluster around ER-mitochondria contact sites and ER quality control (reticulophagy, ER stress regulation, mitochondrion-ER tethering), alongside neuronal functions such as interneuron development, actin- and polarity-related remodeling, and synapse structural plasticity, suggesting a theme of ER\u2013mitochondrial interplay underlying neuronal plasticity. Some outliers (like cytotoxic T cell degranulation) appear annotations noise, but the dominant signal ties ER interactions to neuronal synaptic dynamics.","confidence":"Medium","size":13,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":3},{"id":"GO:0061709","count":2},{"id":"GO:0045054","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0043316","count":2}]},{"hash":"625830602040566302","title":"Xenobiotic Response and Tissue Development","description":"This cluster includes GO terms for responding to amine and cocaine, and cellular response to xenobiotic stimulus, suggesting a xenobiotic-response theme. It also contains developmental terms for substantia nigra, skeletal muscle, and male gonad, indicating tissue development processes. The presence of unrelated biosynthetic terms (lipid A, antibiotic biosynthesis) lowers the coherence, so the overall signal is mixed; thus the label emphasizes xenobiotic response with broad developmental context, rather than a single narrow function.","confidence":"Low","size":13,"edges":22,"triangles":15,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0014075","count":2},{"id":"GO:0017000","count":2},{"id":"GO:1903799","count":2},{"id":"GO:0009245","count":2},{"id":"GO:0042220","count":2}]},{"hash":"486620837155113611","title":"Neural development and signaling with immune components","description":"This cluster links neural development terms (cerebellar cortex formation; Bergmann glial cell differentiation) with broader signaling pathways (insulin receptor signaling; STAT tyrosine phosphorylation) and immune/vascular processes (T cell receptor signaling; lipopolysaccharide response; angiogenesis), suggesting a general theme of signaling and differentiation across neural, metabolic, and immune contexts.","confidence":"Medium","size":13,"edges":14,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0021697","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0048679","count":2}]},{"hash":"129996310700502798","title":"Mitochondrial import and respiratory chain assembly","description":"Based on the top GO terms, the proteins are enriched for mitochondrial functions: import of proteins into mitochondrial inner compartments, assembly of respiratory chain complexes including Complex IV and the respirasome, regulation of cytochrome c release, and maintenance of iron homeostasis and redox balance, as well as responses to oxidative stress. This points to a cohesive mitochondrial maintenance and respiration\u2013related cluster.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006613","count":1},{"id":"GO:0097250","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0090201","count":1},{"id":"GO:0006879","count":1}]},{"hash":"410735191821112910","title":"Membrane Ion and Xenobiotic Transporters","description":"Top GO terms are dominated by ion transmembrane transport (sodium and potassium) and xenobiotic/antibiotic transport, suggesting the cluster centers on membrane transporter proteins. A smaller set of DNA-templated transcription/replication/repair terms appears, but these seem secondary rather than core to the cluster\u2019s function. Thus, the label emphasizes membrane transport activity, particularly ion and xenobiotic transport.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0042891","count":4}]},{"hash":"265489031813153833","title":"Hormone-responsive ion transport in organ development","description":"This cluster combines ion transport terms (bicarbonate, chloride, pH, zinc) with hormone response terms (estrogen, steroid) and developmental terms (kidney development, odontogenesis), plus a fluid shear stress response, suggesting proteins coordinating mineral/ion homeostasis with hormonal signaling in developing organs.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042475","count":1},{"id":"GO:0048545","count":1},{"id":"GO:2001225","count":1},{"id":"GO:0009268","count":1},{"id":"GO:0001822","count":1}]},{"hash":"806147915964010580","title":"LPS-Driven Inflammatory Signaling","description":"The top GO terms point to an innate immune response to lipopolysaccharide and activation of inflammatory pathways (cellular response to LPS, positive regulation of inflammatory and TNF-mediated signaling). Additional terms about gene expression regulation, protein kinase activity, and ubiquitination fit with signaling modulation and protein turnover that accompany inflammatory responses. Some vesicle trafficking and lipid homeostasis terms may reflect membrane dynamics required for signaling and cytokine processing, but the core theme is LPS-triggered inflammation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0050729","count":2},{"id":"GO:0010628","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0055091","count":2}]},{"hash":"348815230259821156","title":"Immune cell chemotaxis and T cell regulation","description":"This cluster shows multiple immune-related terms centered on immune cell movement: macrophage chemotaxis, monocyte chemotaxis, and eosinophil chemotaxis, plus T cell\u2013related regulatory terms (negative regulation of CD4+ T cell proliferation and positive regulation of activated T cell autonomous cell death). These collectively suggest a cohesive theme around immune cell trafficking and T cell regulation, despite a few unrelated terms present. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045445","count":1},{"id":"GO:0006259","count":1},{"id":"GO:0018258","count":1},{"id":"GO:0048246","count":1},{"id":"GO:2000562","count":1}]},{"hash":"1815223698731321318","title":"Mitochondrial Transport and Membrane Dynamics","description":"The top GO terms cluster around transport of metabolites across mitochondrial membranes (ATP, citrate, pyridoxal phosphate, nucleotides), along with regulation of membrane potential and permeability, and mitochondrial fission. Together they point to a coherent theme of mitochondrial metabolite transport and membrane dynamics, with related links to cell death regulation; one outlier term (pregnancy) is likely incidental. ","confidence":"High","size":13,"edges":27,"triangles":20,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1990544","count":6},{"id":"GO:0006843","count":6},{"id":"GO:0070542","count":6},{"id":"GO:0051881","count":6},{"id":"GO:0046902","count":6}]},{"hash":"1113031298957570994","title":"Cilium Assembly and Hedgehog Signaling","description":"The strongest signals are for ciliogenesis-related processes: intraciliary transport, cilium assembly, and the smoothened signaling pathway, which is part of Hedgehog signaling in cilia. Although there are a few unrelated terms (sex differentiation, insulin secretion, T cell signaling), the core terms point to a shared role in cilium formation and Hedgehog signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000249","count":1},{"id":"GO:0035971","count":1},{"id":"GO:0051350","count":1},{"id":"GO:0007548","count":1},{"id":"GO:0035774","count":1}]},{"hash":"433465672195871988","title":"Olfactory perception and behavioral signaling","description":"Based on the top GO terms, the cluster centers on olfactory behavior and detection of chemical stimuli, complemented by neuropeptide signaling and various behavioral regulation processes (larval locomotion, mating, egg-laying, heart rate). This suggests proteins involved in chemical sensing and downstream neural modulation of behavior rather than a single static function.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042048","count":5},{"id":"GO:0050907","count":5},{"id":"GO:1900075","count":1},{"id":"GO:0002209","count":1},{"id":"GO:0007218","count":1}]},{"hash":"1861314241298790393","title":"Neuronal development and calcium signaling","description":"The terms repeatedly point to neuron formation and connectivity (axonogenesis, retinal bipolar neuron differentiation, neuron-associated transport) and calcium signaling (calcium ion detection, calcium-release channel activity), suggesting a cohesive neural development and signaling theme. While there are broader terms like angiogenesis and transcription regulation, the neural-focused terms are the strongest signal for labeling this cluster.","confidence":"Medium","size":13,"edges":17,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0005513","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0019749","count":2}]},{"hash":"53752442897977205","title":"Oocyte Meiosis and Spindle Assembly","description":"The top GO terms cluster around female meiosis, oocyte maturation, and spindle dynamics (spindle assembly in female meiosis I, oocyte maturation, microtubule polymerization) with supporting roles for SCF-dependent proteasomal degradation. Although a few terms relate to brain development, the dominant pattern is meiosis/oocyte-related processes, justifying this label.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":8},{"id":"GO:0046785","count":8},{"id":"GO:0021678","count":8},{"id":"GO:0021993","count":8},{"id":"GO:0070544","count":8}]},{"hash":"617298505239665712","title":"Mitotic Progression and Ubiquitin-Proteasome Regulation","description":"The proteins cluster around mitotic functions (G2/M transition, chromosome segregation, septin ring assembly, microtubule organization) and ubiquitin-mediated proteolysis (SCF-dependent degradation, histone ubiquitination), indicating a cohesive theme of cell division and protein turnover.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":3},{"id":"GO:2000766","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0007059","count":2},{"id":"GO:0035518","count":2}]},{"hash":"336179987218750784","title":"Neural and sensory system development","description":"The terms skew toward development and wiring of nervous/sensory systems (olfaction, chemical-sensing detection, and olfactory behavior; axon guidance and neural crest migration; retina morphogenesis) with supporting morphogenesis processes such as angiogenesis and gland branching, suggesting a cohesive theme of neural/sensory tissue development and organization.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007606","count":1},{"id":"GO:0042048","count":1},{"id":"GO:0050907","count":1},{"id":"GO:0061299","count":1},{"id":"GO:0002042","count":1}]},{"hash":"1774698908263699396","title":"Heart and Muscle Differentiation with VEGF Signaling","description":"This cluster centers on heart and muscle lineage development (heart development, myotube differentiation) and adipocyte differentiation, with signaling pathways including VEGF response and PI3K/AKT as well as insulin-related glucose import and GPCR desensitization. The hyaluronan metabolic process suggests ECM remodeling during tissue differentiation, supporting a role in cardiovascular and skeletal muscle development and associated signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030212","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0045444","count":3},{"id":"GO:0014902","count":3},{"id":"GO:0051897","count":3}]},{"hash":"2114062683530561348","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning neural development and signaling (neuroblast proliferation, GPCR glutamate signaling, endocannabinoid signaling), plant-specific processes (pectin catabolic, camalexin biosynthesis, aerenchyma formation), autophagy (piecemeal microautophagy of the nucleus), and lipid catabolism (diacylglycerol and phosphatidylserine catabolic processes). With no clear, unified function across the cluster and no interaction evidence (Edges/Triangles zero), there isn\u2019t a cohesive biological theme to name this cluster beyond Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007405","count":2},{"id":"GO:0045490","count":1},{"id":"GO:0034727","count":1},{"id":"GO:0042136","count":1},{"id":"GO:0046340","count":1}]},{"hash":"146023247396296105","title":"Neuronal development and synaptic regulation","description":"This cluster has strong signals for neural development and synaptic function, highlighted by axonogenesis and long-term memory, as well as negative regulation of SNARE complex assembly, which impacts neurotransmitter release. Additional terms for GPCR signaling, GTPase regulation, and ubiquitination suggest roles in neuronal signaling and protein trafficking, though some terms may reflect broader processes. Overall, the dominant theme points to neuronal development and synaptic regulation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035544","count":2},{"id":"GO:0045736","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0007616","count":2}]},{"hash":"688339677051842161","title":"Chromatin Remodeling and Stress Responses","description":"The top terms point to chromatin-related processes (subtelomeric heterochromatin formation; histone H3-K9 demethylation) and a range of cellular stress responses (cadmium ion exposure, unfolded protein response, singlet oxygen, gamma radiation). There are also hints of cytoskeletal/neuronal dynamics (actin filament bundle assembly; neuron development), but the dominant signals seem to be chromatin regulation and stress management. This suggests a cluster of proteins involved in coordinating chromatin state under stress, with some peripheral involvement in development-related cytoskeletal changes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0043497","count":1},{"id":"GO:0071276","count":1}]},{"hash":"1578466853306006627","title":"Insect circadian sleep and cholinergic signaling","description":"The top GO terms cluster around circadian rhythms, sleep regulation, rhythmic processes, sensory (odorant) response, and regulation of cholinergic synaptic transmission, along with modulation of potassium channels. This combination strongly points to insect nervous-system\u2013driven circadian and sensory signaling. Some terms like tracheal/tissue development are less central but can reflect broader insect physiology; overall, the theme is coherent. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035158","count":3},{"id":"GO:0048511","count":3},{"id":"GO:1903049","count":3},{"id":"GO:0030431","count":3},{"id":"GO:0008362","count":3}]},{"hash":"135352355217554450","title":"Cartilage Development and Mitotic Regulation","description":"The top GO terms strongly point to cartilage formation (cartilage condensation, collagen signaling, multicellular development) while others highlight cell cycle and mitotic processes (G2/M transition, chromosome segregation, microtubule organization) and protein turnover (ubiquitin-related processes, apoptosis). This suggests a cluster of proteins coordinating cartilage development with cell division control, hence the label.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000086","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0038063","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0001502","count":2}]},{"hash":"976506183328649761","title":"Multisubstrate membrane transporters","description":"The cluster's top GO terms are dominated by transmembrane transport across diverse substrates (nitrate, arabinose, galactose, sodium ions, vitamins, xenobiotics, 4-hydroxyphenylacetate, etc.) with a separate but minor entry for neurotransmitter loading into synaptic vesicles; only a couple of genes touch mRNA splice site recognition, so the dominant theme is membrane transport rather than RNA processing.","confidence":"High","size":12,"edges":19,"triangles":2,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":2},{"id":"GO:1900754","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0015751","count":1}]},{"hash":"688973335623335151","title":"Mitochondrial Transport and Dynamics","description":"The GO terms show a clear mitochondrial focus: ATP and citrate transport across mitochondrial membranes, import of nucleotides and cofactors (pyridoxal phosphate), regulation of membrane potential and permeability, and mitochondrial membrane fission. These collectively point to a cluster of proteins involved in mitochondrial metabolite transport and membrane dynamics, with some signaling context reflected by IGF stimulus and pregnancy terms.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990314","count":2},{"id":"GO:1990544","count":1},{"id":"GO:0006843","count":1},{"id":"GO:0070542","count":1},{"id":"GO:0051881","count":1}]},{"hash":"2160103337271918966","title":"Telomere maintenance and signaling regulation","description":"The top GO terms highlight telomere maintenance control (lengthening, capping, regulation) as a central theme, with additional terms pointing to signaling pathways (Wnt, ephrin receptor signaling) and synaptic regulation, plus protein tetramerization and ADP-ribosylation that support broad regulatory interactions. This suggests a cluster of proteins involved in telomere biology coupled with modulation of signaling processes. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051262","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0070213","count":2},{"id":"GO:1904357","count":2},{"id":"GO:1900383","count":2}]},{"hash":"641423713385305331","title":"Unknown","description":"The GO terms are highly diverse, covering growth signaling, neural development, vesicle trafficking, cytokinesis, translation regulation under ER stress, calcium transport, and chromatin formation, with no single dominant theme linking them. Therefore a coherent, specific cluster label cannot be confidently assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048008","count":3},{"id":"GO:0048666","count":3},{"id":"GO:0034260","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0016191","count":3}]},{"hash":"1381823987846450616","title":"Developmental Signaling and Transcription Regulation","description":"The cluster centers on regulators of signal transduction (tyrosine phosphorylation, GTPase activity, PTK activity, TGF-beta response) and transcription (DNA-templated transcription), with terms pointing to forebrain and skin development. While some entries reflect stress responses (cadmium) or aging, the dominant theme is signaling control linked to development and transcriptional regulation.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050731","count":4},{"id":"GO:0071560","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0000209","count":3}]},{"hash":"1543545399345602616","title":"Steroid and Prostaglandin Biosynthesis","description":"Top GO terms point to lipid-derived hormone production, with multiple steroid biosynthetic processes (cortisol, testosterone, aldosterone) and prostaglandin biosynthesis. While other terms like hepatocyte differentiation and various metabolic processes appear, the strongest signal is lipid hormone synthesis, justifying the label. ","confidence":"High","size":12,"edges":14,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":6},{"id":"GO:0070365","count":5},{"id":"GO:0032094","count":5},{"id":"GO:0032259","count":5},{"id":"GO:0033072","count":4}]},{"hash":"390258178250683547","title":"Unknown","description":"The top terms span immune processes (V(D)J recombination, TNF signaling, I-kappaB phosphorylation), chromatin dynamics (histone acetylation/catabolic processes), protein degradation (ubiquitin-dependent proteolysis), nitric oxide response, viral transport, and cell division (mitotic spindle organization) with no single coherent function dominating; the lack of edges also suggests a loose collection rather than a true functional module.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071732","count":2},{"id":"GO:0007052","count":2},{"id":"GO:2000620","count":1},{"id":"GO:0033151","count":1},{"id":"GO:1903265","count":1}]},{"hash":"2016516919004875624","title":"Endochondral ossification and ECM remodeling","description":"This cluster is dominated by GO terms for cartilage development, collagen fibril organization and endochondral ossification, plus integrin biosynthesis, indicating roles in extracellular matrix assembly/remodeling and bone morphogenesis. A few outlier terms exist, but the core pattern supports cartilage ECM formation and endochondral bone formation as the main theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0001958","count":2}]},{"hash":"1448953928726295061","title":"Epithelial adhesion and morphogenesis","description":"This cluster centers on epithelial cell\u2013cell adhesion and junction maintenance (zonula adherens, epithelial adhesion) with supporting cytoskeletal/microtubule organization, plus developmental roles in somite and mammary gland morphogenesis. Neuron projection development and cholesterol-related membrane processes may reflect shared membrane/cytoskeletal components, but the core theme is adhesion-driven morphogenesis.","confidence":"Medium","size":12,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010923","count":1},{"id":"GO:0031175","count":1},{"id":"GO:0045218","count":1},{"id":"GO:0034453","count":1},{"id":"GO:0090136","count":1}]},{"hash":"2218604678662860330","title":"Developmental transcriptional regulation","description":"This cluster is anchored by DNA-templated transcription and includes several development-related terms (hippocampus, cerebellar cortex, heart development), suggesting proteins involved in transcriptional control during development. Peripheral terms about signaling and stress responses do not overturn this core theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0043433","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0021766","count":2}]},{"hash":"520432236005633629","title":"Rho GTPase\u2013driven signaling and actin remodeling","description":"The cluster shows enrichment for small GTPase-mediated signal transduction and positive regulation of GTPase activity, coupled with actin filament polymerization and dendritic spine morphogenesis, indicating cytoskeletal remodeling driven by GTPase signaling. Additional terms (Wnt pathway regulation, JNK cascade regulation, apoptosis, and DNA damage response) reflect signaling network integration and stress responses that often converge on cytoskeletal dynamics, supporting a cohesive theme of GTPase-dependent signaling guiding actin remodeling, potentially in neuronal contexts.","confidence":"High","size":12,"edges":51,"triangles":121,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0043162","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0006915","count":2}]},{"hash":"715517138025626742","title":"Ribosome Biogenesis and Translation","description":"The top GO terms cluster around translation and ribosome biogenesis, including small subunit and large subunit assembly, SSU rRNA maturation, and translation initiation/cytoplasmic translation, indicating these proteins are core components of the protein synthesis machinery.","confidence":"High","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0042254","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0000028","count":3},{"id":"GO:0002188","count":2}]},{"hash":"1298259740246515724","title":"Unknown","description":"No GO terms, edges, or topology are provided to define a shared function among the 12 proteins (Top Terms is empty; Edges and Triangles are zero). Without functional signals, a meaningful, specific label cannot be inferred, so Unknown is appropriate.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"31791746246785596","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0002188","count":2},{"id":"GO:1901976","count":2}]},{"hash":"2206574086599129947","title":"Neuronal sensory signaling and behavior","description":"The top GO terms converge on neural function: pain perception, startle, locomotion, circadian sleep regulation, drug responses (cocaine, ethanol), and synaptic signaling (calcium transport, excitatory postsynaptic potential). The inclusion of optic nerve morphogenesis is less central but still falls under neural development context, so the overall theme is neuronal signaling and stimulus-driven behavior. Confidence: Medium","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0021631","count":3},{"id":"GO:0060079","count":3},{"id":"GO:1901214","count":3},{"id":"GO:0042220","count":3}]},{"hash":"878562487055043668","title":"Diverse Transmembrane Transporters","description":"The top GO terms are dominated by multiple transmembrane transport processes across a wide range of substrates (ions, sugars, vitamins, xenobiotics, nitrate, etc.), indicating membrane transporter functions. A couple of terms relate to vesicle loading and immune signaling, but the core theme is transport across membranes by transporter proteins.","confidence":"Medium","size":12,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015751","count":2},{"id":"GO:0015706","count":2}]},{"hash":"623071240270529702","title":"Collagen synthesis and ECM remodeling in cartilage/bone formation","description":"The cluster is dominated by GO terms related to collagen biosynthesis/catabolism, collagen fibril organization, and endochondral ossification, plus cartilage development and integrin biosynthesis, pointing to extracellular matrix remodeling during skeletal tissue formation. Some peripheral terms exist but do not override the collagen/ECM theme.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030574","count":3},{"id":"GO:0032964","count":3},{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2}]},{"hash":"1562360545211039198","title":"Steroid and lipid biosynthesis","description":"The top GO terms strongly point to biosynthetic pathways for lipids and steroids (fatty acid elongation and very long-chain fatty acids, testosterone biosynthesis) and related vitamin biosynthetic processes (retinoic acid, phylloquinone). While some terms reference antibiotic responses or transcription regulation, the shared core theme is lipid/sterol/vitamin biosynthesis, making this a concise and representative label.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0055114","count":5},{"id":"GO:0031427","count":4},{"id":"GO:0042761","count":4},{"id":"GO:0030497","count":4}]},{"hash":"1518139275759579533","title":"Developmental signaling and tissue morphogenesis","description":"The proteins appear to be involved in development and tissue organization, with GO terms covering ectoderm formation, metanephric morphogenesis, pancreatic D cell development, and cell-matrix adhesion, along with signaling pathways such as growth hormone receptor signaling and non-canonical NF-kappaB. While a couple of terms like platelet aggregation and miRNA-mediated silencing are less directly related, the overall pattern centers on development and tissue structuring.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":6},{"id":"GO:0035195","count":4},{"id":"GO:0008588","count":4},{"id":"GO:0035995","count":4},{"id":"GO:0060396","count":4}]},{"hash":"51698640205551240","title":"Sulfur metabolism and central carbon biosynthesis","description":"The cluster is dominated by central carbon metabolic processes (TCA cycle, pyruvate biosynthesis) and sulfur-related pathways (transsulfuration, L-cysteine biosynthesis, H2S biosynthesis), with additional links to menaquinone and antibiotic biosynthesis typical of bacterial metabolism. Together, these terms point to a cohesive theme around sulfur-containing amino acid biosynthesis and energy metabolism. ","confidence":"High","size":12,"edges":20,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0019343","count":3},{"id":"GO:0019346","count":3},{"id":"GO:0042866","count":3},{"id":"GO:0070814","count":3}]},{"hash":"1898810130165496898","title":"Unknown","description":"Top GO terms are split between mitochondrial energy metabolism (electron transport, TCA cycle, aerobic respiration) and plant extracellular matrix/cell wall biosynthesis (proteoglycans, cell wall organization, pollen exine). The lack of a single cohesive function or dominant theme makes it unclear what unifies this cluster, so Unknown with no confidence is appropriate.","confidence":"","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006121","count":1},{"id":"GO:0017004","count":1},{"id":"GO:0006099","count":1},{"id":"GO:0009060","count":1},{"id":"GO:0050651","count":1}]},{"hash":"2227931480576557280","title":"Steroid Hormone Biosynthesis","description":"Most of the top GO terms point to biosynthetic processes for steroid hormones (cortisol, testosterone, aldosterone, progesterone) and related sterol metabolism (brassinosteroids). While there are a few peripheral terms (insecticide metabolism, uterus development, inflammatory regulation, antibiotic biosynthesis), the dominant theme is steroid hormone biosynthesis and related sterol pathways, which justifies a label around steroid biosynthesis. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033072","count":5},{"id":"GO:0034651","count":5},{"id":"GO:0061370","count":5},{"id":"GO:0032342","count":5},{"id":"GO:0017143","count":5}]},{"hash":"1456338918165182346","title":"Diverse Developmental Processes","description":"The top GO terms point to development and differentiation across multiple tissues (heart development and cardiac function, fat cell differentiation, enamel mineralization, vaginal development, visual perception) plus broader regulatory processes (miRNA processing, inflammatory response, signaling). This suggests the cluster represents a broad spectrum of developmental and tissue-specific differentiation activities rather than a single cohesive pathway.","confidence":"Medium","size":12,"edges":10,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0060068","count":2},{"id":"GO:1903799","count":2},{"id":"GO:0070166","count":2}]},{"hash":"1346358232784771053","title":"Neural Development and Axon Guidance","description":"The top GO terms are dominated by neural-related processes (hippocampus development, ephrin receptor signaling, positive regulation of canonical Wnt signaling, and regulation of axonogenesis), indicating a cohesive theme around neural development and guidance of neuronal growth. Some terms like kidney development or mating projection growth appear, but the core cluster centers on neuronal development and signaling pathways that direct axon growth and neuronal survival, justifying this label.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021766","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0043525","count":4},{"id":"GO:0031532","count":3},{"id":"GO:0050771","count":3}]},{"hash":"1530137617708878385","title":"Developmental Signaling and Cell Cycle","description":"The top GO terms emphasize cell proliferation (mitotic cell cycle, DNA replication) alongside diverse signaling and developmental processes (neurotrophin TRK signaling, STAT phosphorylation, receptor clustering, angiogenesis, visual perception, actin binding). This pattern suggests a module coordinating growth, development, and associated signaling pathways, rather than a single, narrow function.","confidence":"Medium","size":12,"edges":53,"triangles":119,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":12},{"id":"GO:0007601","count":11},{"id":"GO:0006260","count":11},{"id":"GO:0001525","count":10},{"id":"GO:0071222","count":10}]},{"hash":"96462220022280984","title":"Immune cell chemotaxis and T cell regulation","description":"Most terms point to immune cell movement (macrophage, monocyte, eosinophil chemotaxis) and T cell regulation (negative regulation of CD4-positive T cell proliferation; positive regulation of activated T cell autonomous cell death). While a few terms are less related (DNA metabolic process, root hair development, viral entry regulation), the dominant theme is immune cell recruitment and T cell control, justifying a label centered on immune navigation and regulation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045445","count":1},{"id":"GO:0006259","count":1},{"id":"GO:0018258","count":1},{"id":"GO:0048246","count":1},{"id":"GO:2000562","count":1}]},{"hash":"480013003872781209","title":"Embryonic organ morphogenesis","description":"Most terms point to morphogenesis and development across multiple organs (eye development/morphogenesis, cardiac ventricle morphogenesis, endochondral ossification, endodermal differentiation, gonad/reproductive organ morphogenesis). This suggests a broad embryonic development theme rather than a single pathway. A xenobiotic response term appears incidental/noise.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0048593","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0001654","count":2},{"id":"GO:0008584","count":2}]},{"hash":"1714084300635269748","title":"Ribosome Biogenesis and Translation","description":"The GO terms are dominated by ribosome-related processes: ribosome biogenesis, maturation of SSU-rRNA, ribosomal subunit export from nucleus, translation initiation and termination, and ribosome disassembly, indicating a cohesive theme around ribosome assembly and protein synthesis. A couple of outliers (circadian clock temperature compensation and terminal button organization) appear peripheral to the main function. Overall, the label reflects the core function of the cluster.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006413","count":1},{"id":"GO:0030490","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0060702","count":1},{"id":"GO:0032790","count":1}]},{"hash":"1260713650319639034","title":"Multisystem organ development","description":"The top GO terms cluster around developmental processes across multiple organs (spermatid and male gonad development; heart and nervous system development; mammary gland alveolus development) plus general multicellular growth, suggesting a shared role in organogenesis rather than a single tissue-specific function.  ","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0007286","count":3},{"id":"GO:0043124","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0060749","count":2}]},{"hash":"145810945327420730","title":"Steroid Hormone Biosynthesis and Reproductive Development","description":"Most prominent GO terms are steroid biosynthetic processes (cortisol, testosterone, aldosterone, progesterone) and reproductive development (female gonad development, uterus development), indicating a cluster tied to steroid hormone production and female reproductive biology. Some outlier terms may reflect annotation noise, but the dominant pattern supports this theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":11},{"id":"GO:0060065","count":11},{"id":"GO:0033072","count":10},{"id":"GO:0034651","count":10},{"id":"GO:0061370","count":10}]},{"hash":"661911531242789312","title":"Gonad Development and Meiosis/Cell Cycle Regulation","description":"This cluster\u2019s top GO terms center on reproductive development (male gonad development, oogenesis) and meiotic/cell cycle processes (meiotic mismatch repair, negative regulation of G1/S transition, DNA-templated transcription). While there are a few broader developmental terms, the dominant theme is reproductive development and germline/meiosis-related regulation, justifying the label. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0048477","count":2},{"id":"GO:2000134","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2141264103191678900","title":"Cytoskeletal Remodeling and Cell Migration","description":"The top GO terms center on actin-based protrusions and motility (lamellipodium/filopodium assembly, GTPase activation, cell spreading), indicating cytoskeletal dynamics driving movement; developmental terms like midbrain morphogenesis and vascular remodeling suggest migratory/morphogenetic roles. Some terms appear tangential (obsolete toxin transport, neutrophil degranulation), but the core theme is cytoskeleton-driven migration and development-related morphogenesis.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900119","count":2},{"id":"GO:1901998","count":2},{"id":"GO:0030032","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0043314","count":2}]},{"hash":"607461051800503132","title":"Ribosome Biogenesis and Translation Machinery","description":"Most top GO terms cluster around ribosome production and function: ribosome biogenesis, small subunit assembly, and translation, with protein heterooligomerization likely reflecting ribosomal subunit assembly. The other terms appear incidental or less central (e.g., biosynthesis of O antigen or glycogen), but the dominant signal points to ribosome-related processes.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":2},{"id":"GO:0006407","count":1},{"id":"GO:0000028","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0042254","count":1}]},{"hash":"2130661343559167127","title":"Ectodermal Differentiation and Epithelial Barrier Formation","description":"This cluster centers on processes of barrier formation and ectoderm-derived tissue differentiation: bicellular tight junction assembly, establishment of endothelial barriers, lens fiber cell differentiation, and ectoderm development. While other terms reflect general cell cycle and regulatory mechanisms (centrosome/spindle, transcription regulation, ubiquitination), the strongest shared theme is barrier-related differentiation in ectodermal tissues, supporting the label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":3},{"id":"GO:0007098","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0070306","count":2}]},{"hash":"1503558183497666086","title":"Hormone-Responsive Transcription Initiation","description":"The terms cluster around RNA polymerase II transcription initiation and preinitiation complex assembly, plus hormone-responsive signaling such as estrogen receptor signaling and prolactin response, suggesting a core theme of transcriptional regulation modulated by hormonal signals (with some peripheral terms like vacuolar processing or viral process). ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030520","count":1},{"id":"GO:0035067","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0000296","count":1},{"id":"GO:0006367","count":1}]},{"hash":"1761768932312714058","title":"Skeletal ECM Organization and Endochondral Ossification","description":"The top GO terms concentrate on collagen fibril organization and catabolic processes, cartilage development, and endochondral ossification, along with integrin biosynthesis and related ECM remodeling. This suggests the proteins function together in skeletal extracellular matrix organization and bone/cartilage morphogenesis, despite a few tangential terms. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0001958","count":2}]},{"hash":"240035971867561920","title":"Olfactory-driven insect mating and egg-laying behavior","description":"The top GO terms cluster around behavioral responses tied to mating, egg-laying regulation, and olfactory/chemical sensing, pointing to proteins involved in sensory detection that modulate reproductive behaviors in insects. Some terms are less related (e.g., dermatan sulfate processes), and there are no network edges, so the label is inference from annotations rather than interaction data.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045434","count":2},{"id":"GO:0048042","count":2},{"id":"GO:0002209","count":2},{"id":"GO:1901045","count":2},{"id":"GO:0008345","count":2}]},{"hash":"2200961338622972322","title":"Unknown","description":"The top GO terms are spread across diverse processes, from Fc receptor signaling and cell cycle kinase activity to rRNA maturation, translation under ER stress, calcium transport, chromatin formation, neurotrophin signaling, and actin organization, with no obvious shared pathway or functional core. The absence of edges and a unifying theme indicates no cohesive cluster function can be inferred, so Unknown with None confidence.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060368","count":2},{"id":"GO:0045737","count":2},{"id":"GO:0000462","count":1},{"id":"GO:0040027","count":1},{"id":"GO:0036493","count":1}]},{"hash":"1736885867186412447","title":"Amino Acid and Central Carbon Metabolism","description":"The top GO terms are dominated by amino acid biosynthesis (L-glutamine, L-asparagine) and central carbon metabolism (oxaloacetate, propionate), with additional signals of secondary metabolite biosynthesis (clavulanic and antibiotic biosynthesis) and some transcription/ signaling terms. This suggests a broad metabolic/heavy metabolic-thematic cluster rather than a single narrow pathway, hence a metabolism-focused label with moderate confidence.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":2},{"id":"GO:0070981","count":2},{"id":"GO:0033050","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0010124","count":2}]},{"hash":"1843339255822338075","title":"Vision and Light Perception","description":"Dominant GO terms point to visual perception and light stimulus detection, suggesting a vision-related cluster. The chloride transport terms may reflect ion transport in sensory epithelia involved in photoreception, though a couple of developmental terms appear less connected, introducing partial noise. Overall, the core theme is vision and light sensing.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:1902476","count":2},{"id":"GO:0030321","count":2},{"id":"GO:0050908","count":2},{"id":"GO:0040027","count":1}]},{"hash":"1755007630121838271","title":"Unknown","description":"The terms span diverse contexts from sperm capacitation and heart development to glial differentiation and neuron axonogenesis, plus general processes like cell polarity regulation, PI3K/AKT signaling, transcription, and protein autoprocessing. There isn't a single, cohesive function or pathway that unites all listed terms across these proteins, making it inappropriate to assign a specific, high-confidence label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":2},{"id":"GO:0055015","count":2},{"id":"GO:0060020","count":2},{"id":"GO:0048936","count":2},{"id":"GO:0097284","count":2}]},{"hash":"516856952723831095","title":"Mitochondrial Transport and Membrane Dynamics","description":"The proteins show strong enrichment for transport of various metabolites and components across mitochondrial membranes (ATP, citrate, nucleotides, pyridoxal phosphate) and for membrane regulation processes (membrane potential, permeability, and fission), suggesting a cohesive role in mitochondrial import/transport and membrane remodeling. A single unrelated term (female pregnancy) appears at low frequency, likely annotation noise.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:1990544","count":2},{"id":"GO:0006843","count":2},{"id":"GO:0070542","count":2},{"id":"GO:0051881","count":2}]},{"hash":"1215637318845018621","title":"Unknown","description":"The top GO terms are very mixed, spanning calcium signaling, meiosis-specific DNA double-strand break formation and repair, transcription termination, development, and signaling pathways. There isn\u2019t a single coherent biological function that ties all terms together, so a concise, confident label is not possible based on the available terms. ","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0005513","count":11},{"id":"GO:0060316","count":11},{"id":"GO:0010780","count":11},{"id":"GO:1990918","count":11},{"id":"GO:0030846","count":11}]},{"hash":"266600364126612830","title":"Unknown","description":"There are no GO terms provided in the Top Terms to indicate a shared function, only basic network metrics (edges, triangles, max degree). Without a cohesive functional signal, I cannot assign a meaningful label; the cluster remains Unknown.","confidence":"","size":11,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[]},{"hash":"2078614386317094774","title":"Calcium Transport and Muscle Contraction Regulation","description":"This cluster centers on calcium ion transport across membranes (plasma and mitochondrial) and related ion fluxes (sodium, potassium), together with regulation of heart and skeletal muscle contraction, and calcium-dependent synaptic plasticity (LTP/LTD). The common thread is calcium signaling shaping muscle function and neural signaling.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097369","count":1},{"id":"GO:1990034","count":1},{"id":"GO:0006851","count":1},{"id":"GO:0098735","count":1},{"id":"GO:0060292","count":1}]},{"hash":"1651620765034179455","title":"Multi-Substrate Transmembrane Transporters","description":"The GO terms cluster around transport across the plasma membrane for diverse substrates (ions, sugars, vitamins, xenobiotics, nitrate, selenite) and osmotic stress response, suggesting these proteins function as broad-range membrane transporters.","confidence":"High","size":11,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0097080","count":2}]},{"hash":"626535589959328931","title":"Unknown","description":"The top terms pull from both immune signaling (interleukin pathways) and diverse developmental/cuticle processes (lung/cartilage development, chitin-based cuticle/ecdysis), with no single, cohesive function tying them together. This spread suggests the proteins do not form a clear, unified biological module.","confidence":"","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0070741","count":1},{"id":"GO:0030324","count":1}]},{"hash":"1969502474590735067","title":"Retinal GPCR signaling and phototransduction","description":"This cluster is dominated by vision-related terms (visual perception, regulation of opsin-mediated signaling) and GPCR pathway components (activation of adenylate cyclase, GTPase regulation, calcium release, protein phosphorylation), pointing to retinal phototransduction and GPCR signaling in the eye as the unifying theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0043950","count":2},{"id":"GO:0055117","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0007190","count":2}]},{"hash":"2230978238875132362","title":"Neural Myelination and Cytoskeleton Dynamics","description":"The top terms cluster around oligodendrocyte differentiation and myelination (including peripheral nervous system myelination), plus cytoskeleton remodeling processes such as Rac signaling, lamellipodium assembly, and actin reorganization, suggesting a shared role in neural myelination and the cytoskeletal changes that accompany it and influence synaptic plasticity. Some terms are obsolete, but the core signals point to a cohesive theme of neural myelination coupled with cytoskeletal dynamics.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904261","count":2},{"id":"GO:0048714","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0007016","count":2},{"id":"GO:0051835","count":2}]},{"hash":"1088765737414492489","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0031100","count":2},{"id":"GO:0003360","count":2},{"id":"GO:0009116","count":2},{"id":"GO:0021549","count":2}]},{"hash":"1818253871593010532","title":"Neuronal axon guidance and local translation","description":"The GO terms show strong enrichment for translation and ribosome biogenesis, indicating robust protein synthesis capacity. At the same time, neural-specific processes like axon extension/axogenesis, ephrin receptor signaling, and receptor clustering point to axon guidance and synaptic organization in neural contexts (hippocampus development). Together, these suggest a cluster of proteins involved in axon pathfinding with concurrent local protein synthesis supporting growth and signaling.","confidence":"Medium","size":11,"edges":15,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0045773","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0043113","count":2},{"id":"GO:0021766","count":2}]},{"hash":"1209100831438111359","title":"Unknown","description":"The top GO terms include translation, DNA recombination/metabolic processes, mitochondrial ATP synthesis, and various amino acid catabolic/biosynthetic terms, with no single cohesive function tying them together. The absence of edges and the presence of obsolete terms suggest a non-specific collection rather than a defined pathway, so a precise label cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0033512","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0090305","count":1},{"id":"GO:0006259","count":1}]},{"hash":"789058173757670512","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are dominated by translation (GO:0006412) and ribosomal large subunit biogenesis/assembly, including maturation of rRNA and preribosome assembly, indicating a core cluster of ribosome production and protein synthesis. A few mitosis-related terms also appear, suggesting coordination with cell cycle exit. Retina-related terms are present but far fewer and likely incidental. Overall, the cluster seems centered on ribosome assembly and translation.","confidence":"High","size":11,"edges":32,"triangles":45,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0042273","count":4},{"id":"GO:0007093","count":3},{"id":"GO:0031290","count":3},{"id":"GO:0000462","count":2}]},{"hash":"2268894095071154307","title":"Stress- and Immune-Signaling with Angiogenesis","description":"These proteins seem to participate in signaling pathways that connect environmental stress and immune cues to transcriptional and cellular responses. GO terms include DNA-templated transcription, response to toxic substances, LPS response, STAT phosphorylation, neurotrophin signaling, receptor clustering, and actin cytoskeletal remodeling, with angiogenesis as a notable downstream process. The combination suggests a broader theme of signaling networks governing stress/immune responses and growth-related processes, rather than a single highly specific function. ","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0009636","count":5},{"id":"GO:0001525","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0042517","count":4}]},{"hash":"814027682949913048","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are dominated by ribosome-related processes: translation, translational initiation, ribosomal subunit export from the nucleus, ribosomal biogenesis, and selenocysteine incorporation, suggesting a coherent theme around ribosome assembly and protein synthesis. Additional terms tied to cell division and stress responses may reflect growth-linked regulation of translation. Overall, a label focusing on ribosome biogenesis and translation best captures the cluster.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006413","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0000055","count":1}]},{"hash":"175455522564718168","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":2},{"id":"GO:0001682","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0034965","count":1},{"id":"GO:1905267","count":1}]},{"hash":"1940375034069920997","title":"Hippo-Wnt Growth Signaling and Proliferation Control","description":"The GO terms are dominated by Hippo signaling and positive regulation of canonical Wnt signaling, with related references to proliferation, apoptosis, differentiation, and core genome maintenance processes (DNA replication, transcription, and repair). This suggests a cohesive module coordinating growth signals, cell fate decisions, and genome integrity, anchored by Hippo/Wnt pathways. ","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035329","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0060044","count":6},{"id":"GO:0006915","count":6},{"id":"GO:0030216","count":6}]},{"hash":"2082202469558726654","title":"Neurodevelopmental transcription regulation","description":"The cluster is enriched for transcription-related GO terms (negative regulation of RNA Pol II transcription; DNA-templated transcription; regulation of gene expression) and neural/developmental terms (habenula development, brain segmentation, pituitary development, primitive streak formation), suggesting a core theme of transcriptional control in neurodevelopment and related embryonic patterning.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:2000288","count":4},{"id":"GO:0021986","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0023019","count":3}]},{"hash":"1570838019149817579","title":"Unknown","description":"The GO terms are diverse, spanning heart development, Notch signaling, neural differentiation, circadian regulation, myelination, DNA repair, and inner ear differentiation, with no single dominant theme to bind the proteins together.","confidence":"","size":11,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0003195","count":1},{"id":"GO:0003326","count":1},{"id":"GO:0021858","count":1},{"id":"GO:0003144","count":1},{"id":"GO:0042552","count":1}]},{"hash":"13231726981185443","title":"Coagulation, complement activation, and ECM interactions","description":"The cluster\u2019s top GO terms cluster around blood coagulation, complement activation, integrin-mediated signaling, and cell-matrix adhesion, plus metallopeptidase activity regulation\u2014together pointing to extracellular matrix remodeling and immune/coagulation processes. Some terms (DNA recombination, dendrite regeneration) are outliers, but the dominant pattern supports a coagulation/ECM interaction theme.","confidence":"Medium","size":11,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0009405","count":2},{"id":"GO:0006310","count":2},{"id":"GO:1905050","count":1},{"id":"GO:0007229","count":1}]},{"hash":"833308528554315660","title":"Neuronal signaling and actin dynamics","description":"These terms cluster around neural signal transduction and cytoskeletal remodeling: TRK neurotrophin signaling, receptor clustering, and STAT tyrosine phosphorylation indicate signaling pathways; positive regulation of actin filament binding points to cytoskeletal remodeling crucial for neuronal processes; visual perception aligns with neural function, while angiogenesis and inflammatory response (lipopolysaccharide) can relate to neural development and broader cellular contexts. The mix suggests a primary theme of neuronal signaling coupled with cytoskeletal dynamics, though some terms reflect broader roles. ","confidence":"Medium","size":11,"edges":14,"triangles":5,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0033160","count":8},{"id":"GO:0001525","count":7},{"id":"GO:0071222","count":7}]},{"hash":"1945543997279734467","title":"Melanosome biogenesis and vesicle trafficking","description":"The cluster is dominated by terms related to pigment production and vesicle transport, especially melanosome assembly, pigmentation, COPII vesicle coating, and ER-Golgi/intra-Golgi transport, pointing to a cohesively shared function in pigment-related organelle biogenesis and secretory trafficking; Autophagy and regulatory terms fit within broader vesicle dynamics but do not override the central melanosome/pigmentation theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048208","count":1},{"id":"GO:0042338","count":1},{"id":"GO:0006914","count":1},{"id":"GO:0043473","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1557339137717734409","title":"Neuronal development and maturation","description":"This cluster is dominated by neuronal development terms, including in utero embryonic development, neuron maturation, and neuron projection extension, indicating a focus on neural formation and growth. The presence of metabolic cofactor and general metabolism terms appears supplementary, not central to the main theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":6},{"id":"GO:0042551","count":6},{"id":"GO:0009228","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0046653","count":5}]},{"hash":"2255876842155820728","title":"Developmental patterning and organogenesis","description":"This cluster centers on embryonic development and tissue patterning, with multiple GO terms referencing morphogenesis (mammary gland, somite) and differentiation/patterning of neural and kidney structures, plus Hedgehog/Smoothened signaling in dorsal-ventral neural tube patterning. Although there is a cholesterol metabolism item, the dominant theme is developmental morphogenesis and tissue specification, making this label representative.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060603","count":1},{"id":"GO:0061053","count":1},{"id":"GO:0040015","count":1},{"id":"GO:0008203","count":1},{"id":"GO:0033344","count":1}]},{"hash":"1746139831607366183","title":"Mitotic cell cycle progression","description":"Top terms are dominated by mitosis-related processes (G1/S and G2/M transitions, re-entry into mitosis, chromosome condensation) and DNA-templated transcription, indicating a cohesive role in cell cycle entry and mitotic progression. Development-related proliferation terms are present but secondary, so the core signal points to mitotic control and cell cycle progression.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":8},{"id":"GO:0000086","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0000320","count":7}]},{"hash":"296079486692002191","title":"Photoreceptor Maintenance and Visual Perception","description":"The cluster is enriched for GO terms tied to the visual system, especially photoreceptor maintenance (GO:0045494) and visual perception (GO:0007601). Other terms (apoptotic signaling, ubiquitination, mitochondria) appear more as ancillary stress-related processes, but do not override the retinal function signal. Therefore, a retinal photoreceptor\u2013focused label is appropriate.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902230","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0042771","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0043547","count":2}]},{"hash":"2077175558424995417","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0051259","count":2},{"id":"GO:0071630","count":2},{"id":"GO:0071374","count":2}]},{"hash":"781695185784405508","title":"Cartilage and ECM remodeling","description":"Top GO terms point to cartilage development and endochondral ossification, as well as collagen fibril organization and catabolic processes, all of which reflect extracellular matrix formation and remodeling in skeletal tissues. While a few terms touch on unrelated processes (podocyte development, lipoprotein clearance, heterotrimerization), the dominant signal supports a cartilage/ECM remodeling theme, hence this label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":1},{"id":"GO:0033034","count":1},{"id":"GO:0060351","count":1},{"id":"GO:0045112","count":1},{"id":"GO:0001958","count":1}]},{"hash":"592245780521010379","title":"Organogenesis and angiogenic signaling","description":"The cluster\u2019s GO terms cluster around developmental processes and signaling pathways, including endodermal differentiation, nephron and skin development, integrin signaling, and TGF-beta receptor signaling, as well as cell migration in sprouting angiogenesis. This suggests a cohesive theme of organogenesis and tissue morphogenesis with ECM-related signaling, despite a couple of terms that appear less directly connected (memory, exploration behavior). ","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045715","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0033343","count":1},{"id":"GO:0007229","count":1}]},{"hash":"884300299264951558","title":"Flavonoid and lignin biosynthesis","description":"Most of the top GO terms point to biosynthetic pathways for flavonoids (cyanidin, quercetin, kaempferol, anthocyanin) and lignin, plus related glycosylation steps. This suggests the cluster groups proteins involved in plant secondary metabolite production rather than a single cellular process. A few terms (biphenyl catabolic, antibiotic metabolism) relate to aromatic compound processing and may reflect broader metabolism or annotation noise; the paranode axon localization term seems unrelated to plant metabolism and could be an artifact. Overall, the cluster appears to be flavonoid and lignin biosynthetic proteins.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009808","count":11},{"id":"GO:0033485","count":11},{"id":"GO:0070980","count":11},{"id":"GO:0033330","count":11},{"id":"GO:0052696","count":11}]},{"hash":"2063917949240009370","title":"Unknown","description":"The terms span redox processes, stress responses (cold, starvation), lipid metabolism (glycerol and phospholipid dephosphorylation), cytoskeletal remodeling (actin rod assembly), a developmental term (lung development), and even a bacterial biosynthetic pathway, suggesting no clear, coherent function that unites the cluster. This mix likely reflects annotation noise rather than a single biological module.","confidence":"","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0030324","count":3},{"id":"GO:0009409","count":3},{"id":"GO:0042594","count":3},{"id":"GO:0016311","count":2}]},{"hash":"1387702905350956917","title":"Embryonic organ morphogenesis and axis patterning","description":"This cluster centers on developmental processes across multiple organs and body axes, including dorsal aorta development, left/right axis specification, pericardium and valve morphogenesis, auditory receptor fate, cerebellar layer formation, and oocyte localization. While some terms hint at signaling responses (VEGF stimulus, muramyl dipeptide), the dominant signal is organogenesis and patterning, suggesting a general embryonic development theme rather than a single pathway. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035924","count":5},{"id":"GO:0032495","count":5},{"id":"GO:0034351","count":5},{"id":"GO:0009912","count":4},{"id":"GO:0035907","count":4}]},{"hash":"215768756539796615","title":"Neuronal development and synaptic assembly","description":"The cluster is dominated by GO terms related to nervous system development, dendritic spine formation, and synaptic vesicle dynamics, along with tubulin complex assembly and small GTPase signaling, suggesting a cohesive role in neuronal development and synaptic trafficking.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060999","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0046909","count":7},{"id":"GO:0034629","count":7},{"id":"GO:0051301","count":7}]},{"hash":"1605212220081853595","title":"Neurotransmitter signaling and autonomic CV regulation","description":"The cluster centers on neuromodulator signaling (dopamine, octopamine/tyramine, norepinephrine/epinephrine) and autonomic control of cardiovascular functions, including vasodilation and saliva secretion, with related terms touching neuronal development and heart morphogenesis. This suggests a coherent theme of neuroendocrine signaling guiding cardiovascular regulation and related secretory processes, despite some broader or metabolic terms present.","confidence":"Medium","size":11,"edges":11,"triangles":2,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":6},{"id":"GO:0031635","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0002025","count":5},{"id":"GO:0022900","count":5}]},{"hash":"2202858466858848876","title":"Fungal cell wall biosynthesis and septation","description":"These proteins co-occur with GO terms centered on fungal-type cell wall biogenesis, mannoprotein and galactomannan/mannan biosynthesis, and N-linked glycosylation, plus processes like mucilage biosynthesis, cell budding, and division septum assembly. The pattern suggests a cohesive theme of fungal cell wall construction and remodeling coupled to cell division, with glycoprotein components being key structural elements. ","confidence":"High","size":11,"edges":22,"triangles":22,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009272","count":1},{"id":"GO:0042125","count":1},{"id":"GO:0051070","count":1},{"id":"GO:0000032","count":1},{"id":"GO:0006487","count":1}]},{"hash":"1820900650768865035","title":"Unknown","description":"There are no edges or GO terms to define a shared function for these proteins (0 edges, 0 triangles, and no top terms), so a meaningful common label cannot be determined.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2023279096564260930","title":"Developmental signaling and stress responses","description":"The Top Terms include developmental processes (kidney development, nervous system development) and multiple signaling pathways (Smoothened/Hedgehog, Roundabout/Robo, T cell receptor signaling), alongside stress and trafficking-related terms (isolation stress response, mitochondrial outer membrane permeabilization, reticulophagy, constitutive secretory pathway). This suggests a cluster of proteins involved in signaling that governs development, often in the context of cellular stress or quality control, rather than a single, narrow function. ","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0035900","count":4},{"id":"GO:0097345","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0050852","count":4}]},{"hash":"1571432775291692506","title":"Cartilage and Bone Morphogenesis","description":"This cluster is dominated by terms related to skeletal development, including cartilage development involved in endochondral bone morphogenesis and endochondral ossification, with supporting cell-adhesion and integrin biosynthetic processes, suggesting a cohesive role in skeletal tissue formation and matrix interactions.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0040032","count":2},{"id":"GO:0042338","count":2},{"id":"GO:0090201","count":2},{"id":"GO:0070208","count":1}]},{"hash":"2028132959901759873","title":"Neuronal development and synaptic regulation","description":"The top GO terms are dominated by neural-related processes: neuronal maturation, axon growth and fasciculation, synaptic plasticity (long-term potentiation), and calcium-dependent exocytosis, with transcriptional control underpinning these programs. A few terms pertain to cardiac or mammary gland branching, which may reflect broader developmental annotations rather than core features of this cluster. Overall, the cluster appears to reflect neuronal development and synaptic function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0060045","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0097156","count":2},{"id":"GO:0060044","count":2}]},{"hash":"1315164654482787777","title":"Neuronal Transmembrane Transport","description":"This cluster centers on GO terms for transmembrane transport of ions and small molecules (ammonium, rubidium, carnitine, polyamines, GABA) and general transmembrane transport, with neuron-associated terms like thermosensory behavior and dendritic spine development; the shared theme is membrane transport activities that support ion balance and neurotransmitter handling in neural contexts.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0070634","count":1},{"id":"GO:0040040","count":1},{"id":"GO:0035826","count":1},{"id":"GO:0055085","count":1},{"id":"GO:0071477","count":1}]},{"hash":"1740083768160872127","title":"Cellular Stress Response and Protein Homeostasis","description":"The top GO terms point to responses to oxidative and DNA-damaging stresses (hydrogen peroxide, UV-A, gamma radiation) together with protein quality control activities (deubiquitination, protein stabilization, regulation of protein interactions). This suggests a cluster centered on sensing and mitigating cellular stress through maintaining protein integrity, even though a few terms like estradiol response and muscle contraction are less coherent with this theme and may reflect broader or context-specific annotations. Therefore the label emphasizes the core shared function of stress response coupled to protein homeostasis.","confidence":"Medium","size":11,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032355","count":5},{"id":"GO:0016579","count":4},{"id":"GO:2000378","count":4},{"id":"GO:0042542","count":4},{"id":"GO:0006936","count":4}]},{"hash":"1193684532901410377","title":"Proton gradient\u2013driven energy metabolism","description":"This cluster centers on processes using proton gradients to generate or regulate energy and organelle pH: proton transmembrane transport, proton motive force\u2013driven ATP synthesis, and vacuolar acidification. Additional terms touch on amino acid homeostasis and differentiation/regulation during development, which may reflect linked cellular states but are less central to the core energy theme. Overall, the dominant shared link is energy metabolism governed by proton gradients and organelle acidification.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0090463","count":2},{"id":"GO:0001649","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0090464","count":2}]},{"hash":"612884700574242979","title":"Unknown","description":"The top GO terms span neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration), metabolic signaling (insulin receptor signaling, glucose import), immune responses (T cell signaling, lipopolysaccharide response), angiogenesis, receptor clustering, and even meiosis kinetochore regulation. The terms are heterogeneous with no clear common function tying all 11 proteins together, and there are no interactions (edges) observed, so there isn\u2019t a cohesive label to represent the cluster.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":11},{"id":"GO:0021697","count":11},{"id":"GO:0008286","count":11},{"id":"GO:0048679","count":11},{"id":"GO:0060020","count":11}]},{"hash":"233712167113866067","title":"Developmental Transcription and Inflammatory Signaling","description":"The cluster centers on transcriptional regulation and developmental processes (DNA-templated transcription, placenta/vagina development, fat cell differentiation) and also includes inflammatory/stress signaling (cellular response to lipopolysaccharide, p38 MAPK cascade) with retinoic acid response. The absence of network edges suggests broad, cross-cutting functions, so the label reflects both developmental differentiation and inflammatory signaling themes.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0060068","count":5},{"id":"GO:0043433","count":5}]},{"hash":"162746866423235683","title":"Unknown","description":"The top terms are highly heterogeneous, spanning genital disc development, sex determination, IGF receptor signaling, PKC and Akt activation, transcription by RNA polymerase III, Schwann cell differentiation, UV response, and respiratory burst regulation, with no single dominant process linking them. Therefore a cohesive, specific label cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035225","count":1},{"id":"GO:0070141","count":1},{"id":"GO:0048009","count":1},{"id":"GO:0060267","count":1},{"id":"GO:0045945","count":1}]},{"hash":"1102758421642999374","title":"Nematode Molting and Pharyngeal Pumping","description":"These terms point to nematode-specific biology: molting involving collagen/cuticle and nematode pharyngeal pumping. Together they suggest a broad theme of nematode development and feeding, though the evidence is weak (only two terms and no edges), so the label is a best-guess.","confidence":"Low","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":1},{"id":"GO:0043050","count":1}]},{"hash":"1451752446678622725","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0046784","count":1},{"id":"GO:0002188","count":1},{"id":"GO:1901976","count":1},{"id":"GO:0035264","count":1}]},{"hash":"2001168452235093807","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0070478","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000472","count":2}]},{"hash":"845532282770362796","title":"Unknown","description":"Terms cover kidney tubule morphogenesis and several innate-immune processes with no single unifying function, so there is no cohesive theme to label the cluster.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":1},{"id":"GO:0072237","count":1},{"id":"GO:0036303","count":1},{"id":"GO:0072287","count":1},{"id":"GO:0002223","count":1}]},{"hash":"1331757168175915592","title":"Neurodevelopment and angiogenesis","description":"The top GO terms include telencephalon development and axon regeneration (neural development) and angiogenesis (blood vessel formation), suggesting a theme of brain development with neurovascular interactions. Additional terms like cellular response to lipopolysaccharide (inflammation) and receptor clustering indicate signaling and immune-related modulation in neural contexts. While some terms are more general, the predominant pattern centers on neural development with supporting vascular and immune signaling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0090169","count":1},{"id":"GO:0048679","count":1},{"id":"GO:0021537","count":1}]},{"hash":"2273672181281717947","title":"Neural development and cytoskeletal signaling","description":"The cluster is driven by terms reflecting neuronal growth and signaling, notably axonogenesis and neurotrophin TRK receptor pathways, together with actin cytoskeleton regulation (positive regulation of actin filaments, cell polarity). The accompanying vascular signals (angiogenesis, angiotensin-activated heart signaling, endothelin response) suggest coordination between neural development and vascular remodeling. While a few terms are broader, the core pattern points to neural growth with cytoskeletal dynamics and associated vascular signaling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0036493","count":1},{"id":"GO:2001275","count":1},{"id":"GO:0048011","count":1},{"id":"GO:0070669","count":1}]},{"hash":"1988937577495185591","title":"Developmental signaling and innate immunity","description":"The GO terms cluster around developmental signaling and remodeling (integrin signaling, axon guidance, growth regulation, molting) alongside innate immune and epithelial defense activities (defense against bacteria, cytolysis, engulfment of apoptotic cells, bacterial agglutination). This suggests proteins involved in organismal development with concurrent roles in immune responses, rather than a single narrow function. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0043050","count":1},{"id":"GO:0042742","count":1},{"id":"GO:0019835","count":1},{"id":"GO:0043652","count":1}]},{"hash":"2208449396253236945","title":"Cell-cycle and stress response","description":"The top GO terms cluster around cell division and DNA replication machinery (centrosome cycle, mitotic spindle assembly, positive regulation of nuclear DNA replication) and transcription/ubiquitination processes, with accompanying stress responses (cadmium ion exposure, ER-stress\u2013related apoptosis) and a defense signal. This suggests a cohesive theme of coordinating cell-cycle control with cellular stress signaling, while a forebrain development term appears as a less central outlier. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0007098","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0010571","count":2}]},{"hash":"2254128089481752187","title":"Megakaryocyte and platelet development","description":"The top GO terms show a strongest signal for megakaryocyte development (GO:0035855) and heart development (GO:0032516), each with two instances, plus platelet formation (GO:0021629). This pattern suggests a cluster centered on hematopoietic/vascular differentiation and platelet biology, despite several outlier terms that are less related (olfactory nerve organization, heterochromatin formation, unfolded protein response, blood\u2013nerve barrier, macrophage foam cell differentiation). Overall, the core theme points to megakaryocyte/platelet development and associated cardiovascular processes.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035855","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006990","count":1},{"id":"GO:0021629","count":1}]},{"hash":"1877098914156538671","title":"Plant cell wall remodeling and plasmodesmata","description":"The top terms point to plant-specific processes: modification and regulation of plant-type cell wall cellulose biosynthesis and plasmodesma organization, suggesting a cluster focused on cell wall remodeling and intercellular connectivity in plants. Other terms (mitochondrial transport and metabolism) appear as secondary associations and do not redefine the main theme, so the label emphasizes the dominant plant cell wall/plasmodesmata functions. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":2},{"id":"GO:2001009","count":2},{"id":"GO:0009663","count":2},{"id":"GO:1990544","count":1},{"id":"GO:0006843","count":1}]},{"hash":"1297124381906771000","title":"Synaptic Receptor Clustering and Plasticity","description":"The cluster\u2019s GO terms are dominated by neuronal synapse-related processes, notably NMDA and AMPA receptor clustering and regulation of long-term synaptic plasticity, indicating a clear theme of synapse organization and neuronal signaling. Other terms (transmembrane transport, cell adhesion) are present but less defining, and a few unrelated terms appear, but they do not override the main synaptic focus.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045953","count":3},{"id":"GO:0055085","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0097114","count":2}]},{"hash":"523089268174987133","title":"Reproductive development and hormone signaling","description":"The top GO terms point to transcriptional regulation (DNA-templated transcription) together with development of reproductive tissues (male gonad, prostate gland) and thyroid hormone receptor signaling, suggesting a cluster centered on transcriptional control during reproductive development and endocrine responses. Some terms (e.g., immune signaling) may reflect broader regulatory networks but do not override the dominant theme of developmental transcription and hormone signaling in reproductive contexts.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0008584","count":3},{"id":"GO:0071222","count":2},{"id":"GO:0035264","count":2},{"id":"GO:2001275","count":2}]},{"hash":"444127883569765945","title":"Developmental differentiation in reproductive and adipose tissues","description":"This cluster is driven by terms tied to tissue development (placenta and vagina) and adipocyte differentiation, supported by signaling and transcriptional regulation (retinoic acid response, p38 MAPK cascade, DNA-templated transcription). While an immune response to lipopolysaccharide is present, the dominant theme appears to be developmental signaling and differentiation in reproductive and adipose lineages.","confidence":"Medium","size":10,"edges":6,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":6},{"id":"GO:0001890","count":6},{"id":"GO:2001275","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0060068","count":5}]},{"hash":"1750353076478705183","title":"Potassium ion homeostasis and membrane potential regulation","description":"The top GO terms cluster around stabilization and regulation of membrane potential, potassium ion homeostasis and potassium transmembrane transport, and regulation of resting membrane potential, pointing to a module centered on ion transport and cellular excitability. Peripheral signals such as mechanosensation, adrenergic vasodilation, opioid signaling, electron transport, and proliferation appear secondary to this core theme.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030322","count":3},{"id":"GO:0098914","count":3},{"id":"GO:0030007","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0060075","count":3}]},{"hash":"267701533491860253","title":"GPCR Signaling Pathways","description":"This cluster centers on G protein-coupled receptor (GPCR) signaling. The top GO terms point to pathways where GPCRs activate adenylyl cyclase and PK signaling (e.g., dopamine/adrenergic receptor pathways) and phospholipase C, plus related cAMP and PI signaling, with ties to phototransduction and sensory processes. The presence of temperature- and thermogenesis-related terms suggests involvement in metabolic regulation via GPCR signaling, supporting a cohesive GPCR signaling module rather than disparate processes.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0010513","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0071880","count":5}]},{"hash":"1634616032030194760","title":"Unknown","description":"The terms span metal stress response, transcription, various developmental processes, metabolism, learning, and immune signaling with no single shared function, so a coherent label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0070059","count":4}]},{"hash":"779547652777718905","title":"Innate antiviral response and translational control","description":"The GO terms cluster around innate immune defense against viruses, including cellular response to virus and negative regulation of viral genome replication, plus translational control elements such as mRNA processing and regulation of translation initiation by eIF2\u03b1 phosphorylation. Receptor clustering and toxin response further support a stress-related immune signaling context. This combination suggests a cohesive theme of antiviral innate immunity with post-transcriptional regulation of protein synthesis.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":5},{"id":"GO:0045071","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0098586","count":4},{"id":"GO:0006397","count":4}]},{"hash":"263926047611117660","title":"Cellular Stress Response and Translation Regulation","description":"The dominant GO terms point to diverse cellular stress responses (oxidative stress from hydrogen peroxide, UV-C exposure, acidic pH, and amino acid starvation) and to regulation of cytoplasmic translation in response to stress, with additional links to SUMOylation; together these suggest a coherent theme of stress sensing and stress-adaptive translation control, despite a few outliers such as neuron projection extension. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097201","count":1},{"id":"GO:0070301","count":1},{"id":"GO:1990138","count":1},{"id":"GO:0071494","count":1},{"id":"GO:1990451","count":1}]},{"hash":"1180486739587668042","title":"Blood coagulation and erythrocyte differentiation","description":"The top GO terms point mainly to hematology-related processes: blood coagulation and platelet aggregation, along with enucleate erythrocyte differentiation (erythrocyte maturation) and RBC-associated transport activities. There are also oxidative stress and detoxification terms typical for circulating blood cells, supporting a theme centered on hemostasis and red blood cell biology rather than a single signaling pathway. Confidence: Medium","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0042542","count":1},{"id":"GO:0006898","count":1},{"id":"GO:0032966","count":1}]},{"hash":"765669341195288354","title":"Proteolysis and Blood Vessel Regulation","description":"The strongest signal is proteolysis, with accompanying vascular-regulation terms (endothelial migration, angiogenesis, kallikrein-kinin cascade, blood pressure regulation) suggesting a cluster focused on proteolytic control of vascular homeostasis, with metabolism terms as secondary context.","confidence":"High","size":10,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":5},{"id":"GO:2000678","count":3},{"id":"GO:0043535","count":3},{"id":"GO:2000377","count":3},{"id":"GO:0002353","count":3}]},{"hash":"1066577831013189061","title":"Multi-tissue Development and Organogenesis","description":"The top GO terms point to development across multiple tissues (brain, retina/eye, pituitary, osteoblasts, and gonads) plus related transcriptional regulation, suggesting a broad theme of tissue-specific organogenesis rather than a single shared function. Despite no direct interactions in the cluster, the recurring emphasis on development across diverse organs supports a label emphasizing multi-tissue developmental processes.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0060041","count":2},{"id":"GO:0002087","count":2}]},{"hash":"1475722747156742553","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060315","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0006458","count":2},{"id":"GO:0042542","count":2},{"id":"GO:0022417","count":2}]},{"hash":"1462802857938552456","title":"ER-Golgi trafficking and ER\u2013mitochondria tethering","description":"The terms cluster around ER-centered processes and membrane trafficking (ER to Golgi transport, constitutive secretory pathway, and reticulophagy) and include ER\u2013mitochondria tethering, suggesting a core module of ER-driven trafficking and organelle contact. Additional terms point to cytoskeletal remodeling and synaptic/plasticity-related roles that often accompany trafficking and organelle dynamics. Overall, a concise label capturing ER/Golgi trafficking with organelle tethering best fits the shared functions.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0040027","count":1},{"id":"GO:0061709","count":1},{"id":"GO:0045054","count":1},{"id":"GO:0071963","count":1},{"id":"GO:0043316","count":1}]},{"hash":"1621433324641524679","title":"ER Stress and Protein Quality Control","description":"The proteins group show strong enrichment for ER stress\u2013related processes (ERAD, aggrephagy, ubiquitination, ER-stress\u2013driven apoptosis) and general protein quality control, plus translation regulation and transcription. While immune signaling terms are present, the dominant theme is cellular proteostasis under stress.","confidence":"Medium","size":10,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035278","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0035973","count":1}]},{"hash":"148574435874886584","title":"Cartilage and Endochondral Bone Morphogenesis","description":"The GO terms are dominated by cartilage development, endochondral ossification, collagen fibril organization, and ECM remodeling, with support from integrin biosynthesis. These point to connective tissue formation and bone development as the core theme, with a few ancillary processes (podocyte development, lipoprotein clearance) that do not alter the primary function.","confidence":"High","size":10,"edges":11,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":5},{"id":"GO:0033034","count":5},{"id":"GO:0060351","count":5},{"id":"GO:0045112","count":5},{"id":"GO:0001958","count":5}]},{"hash":"1415435090453970698","title":"Cartilage and Bone ECM Remodeling","description":"These proteins are linked by terms related to cartilage development, endochondral ossification, collagen fibril organization and turnover, and integrin biosynthesis, all pointing to extracellular matrix remodeling during skeletal development and bone formation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":6},{"id":"GO:0033034","count":6},{"id":"GO:0060351","count":6},{"id":"GO:0045112","count":6},{"id":"GO:0001958","count":6}]},{"hash":"455258124961449141","title":"Unknown","description":"The terms span diverse processes (chloride transport, PHB biosynthesis, detoxification, DNA repair, toxin catabolism, amino acid response, growth), with several obsolete GO entries, indicating no single cohesive function for the cluster. Because there is no clear common pathway or function tying these proteins together, I cannot assign a specific, representative label beyond Unknown.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902476","count":3},{"id":"GO:0042619","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0098869","count":2}]},{"hash":"2288682458046484661","title":"Unknown","description":"The GO terms are spread across meiotic DNA double-strand break formation and repair, transcription termination, calcium ion detection, and various unrelated processes (lung development, glucose signaling). With no clear dominant function or cohesive theme and no network connectivity, there isn\u2019t a well-supported label for this cluster.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005513","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0010780","count":2},{"id":"GO:1990918","count":2},{"id":"GO:0030846","count":2}]},{"hash":"895159773817560399","title":"Cartilage development and collagen remodeling","description":"This cluster centers on extracellular matrix (ECM) assembly and remodeling tied to cartilage and bone formation. Dominant terms include cartilage development in endochondral ossification, endochondral ossification, and collagen fibril organization with collagen catabolic processes, pointing to active ECM turnover during skeletal development. Integrin biosynthetic process supports cell-ECM adhesion crucial for ECM assembly, while the more peripheral terms (podocyte development, plasma lipoprotein clearance, PDGFR signaling) may reflect broader connective tissue and vascular interactions.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3},{"id":"GO:0045112","count":3},{"id":"GO:0001958","count":3}]},{"hash":"1522997608873728655","title":"Cartilage Development and Endochondral Ossification","description":"The dominant signals are cartilage development and endochondral ossification, plus related extracellular matrix (collagen fibril organization and catabolic remodeling) and integrin biosynthesis, all points to ECM remodeling during cartilage and bone formation. A couple of terms (lipoprotein clearance, podocyte development) seem peripheral to this core theme but do not outweigh the cartilage/bone biology signal.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":5},{"id":"GO:0033034","count":5},{"id":"GO:0060351","count":5},{"id":"GO:0045112","count":5},{"id":"GO:0001958","count":5}]},{"hash":"1415504270060738618","title":"Proteoglycan biosynthesis and tissue morphogenesis","description":"The terms center on synthesis of chondroitin sulfate and heparan sulfate proteoglycans, which are key extracellular matrix components guiding cell adhesion and tissue morphogenesis. UDP-D-xylose is a sugar donor for glycosaminoglycan biosynthesis, tying these processes together; a few other terms like intestinal absorption or thyroid hormone metabolism appear ancillary to broader metabolic activity but do not define the cluster.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048729","count":1},{"id":"GO:0050650","count":1},{"id":"GO:0015012","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0060352","count":1}]},{"hash":"14382850873614290","title":"Cell Cycle Control and Neural Differentiation","description":"The top GO terms show strong enrichment for cell cycle regulation (negative regulation of cyclin-dependent kinase activity, DNA replication, negative regulation of proliferation) and neural development (cerebellar cortex formation, Bergmann glial cell differentiation, axon regeneration), with some broad signaling pathways (insulin receptor, T cell receptor) present but less central. This suggests the cluster centers on coordinating cell cycle control with neural differentiation processes.","confidence":"Medium","size":10,"edges":29,"triangles":38,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045736","count":8},{"id":"GO:0034501","count":8},{"id":"GO:2001275","count":7},{"id":"GO:0008285","count":7},{"id":"GO:0021697","count":7}]},{"hash":"67879536726489861","title":"Ubiquitin-Proteasome System","description":"The cluster is dominated by GO terms related to ubiquitination and proteasomal degradation, including ubiquitin-dependent protein catabolic process, SCF-dependent proteasomal degradation, and both K48- and K63-linked ubiquitination, indicating a core function in tagging substrates for proteolysis. While a few terms touch on immune signaling or vesicle transport, the strongest signal is the ubiquitin-proteasome pathway, justifying this label.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0070936","count":2}]},{"hash":"949964950092639121","title":"Drosophila wing morphogenesis and actin remodeling","description":"This cluster centers on wing imaginal disc development and cytoskeletal dynamics, highlighted by terms like establishment of imaginal disc-derived wing hair orientation, cleavage furrow formation, and positive regulation of actin filament binding. These suggest a common theme of actin cytoskeleton remodeling during Drosophila morphogenesis, with a few unrelated terms likely noise. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014070","count":2},{"id":"GO:0060670","count":2},{"id":"GO:0036493","count":1},{"id":"GO:0036089","count":1},{"id":"GO:0001737","count":1}]},{"hash":"355753577215313495","title":"Mitochondrial dynamics and immune signaling","description":"Dominant terms describe mitochondrial membrane potential regulation, inner mitochondrial membrane organization, and stress-induced mitochondrial fusion, indicating mitochondrial dynamics as the core function. Also present are immune signaling and cell\u2013cell interaction terms (TLR3 signaling, T cell polarity, cadherin-mediated adhesion), suggesting a broader link between mitochondrial regulation and immune/cell adhesion processes. With some obsolete terms and no observed network edges, the label is of Medium confidence.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001302","count":2},{"id":"GO:0010918","count":1},{"id":"GO:0034141","count":1},{"id":"GO:0007007","count":1},{"id":"GO:0070528","count":1}]},{"hash":"868632054328605111","title":"Actin Cytoskeleton Remodeling","description":"This cluster is dominated by terms related to actin dynamics, including regulation of lamellipodium and focal adhesion assembly, localization to actin cortical patches, and sarcomere organization, all pointing to cytoskeletal remodeling and cell adhesion. Some terms also reflect stress or inflammatory signaling (interleukin-1, hydrogen peroxide) that can influence cytoskeletal behavior, suggesting cross-talk between signaling and structural regulation. Overall, the proteins appear geared toward actin-based organization and motility rather than a single enzymatic pathway, albeit with sparse direct connectivity. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0010593","count":1},{"id":"GO:0051894","count":1},{"id":"GO:0070301","count":1}]},{"hash":"967891885262337364","title":"Ubiquitin-Dependent Proteolysis and NF-\u03baB Signaling","description":"The top GO terms cluster around ubiquitin-dependent protein degradation, including multiple ubiquitin linkages (K48, K63, K6) and autoubiquitination, as well as related ERAD processes, with additional terms for canonical NF-\u03baB signaling regulation and apoptosis. This suggests a functional group of proteins tied to ubiquitin-mediated proteolysis and control of NF-\u03baB\u2013dependent pathways, with apoptotic connections. Although there are no edges among the proteins in this dataset, the shared ubiquitination-centric annotations provide a coherent theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0070534","count":4},{"id":"GO:0051026","count":4},{"id":"GO:0070936","count":4},{"id":"GO:0085020","count":4}]},{"hash":"1189282083549360191","title":"Unknown","description":"The GO terms are diverse, spanning locomotion, development (dorsal closure), receptor recycling, phosphatidylinositol catabolism, vacuole organization, myelin-related processes, and cardiac hypertrophy, with no clear shared pathway or core function; edges are absent, so no cohesive theme emerges. ","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043059","count":1},{"id":"GO:0046664","count":1},{"id":"GO:0043058","count":1},{"id":"GO:0001921","count":1},{"id":"GO:0031161","count":1}]},{"hash":"1127149194463364092","title":"Auditory mechanosensory signaling and cochlear development","description":"The terms center on hearing-related processes (detection of mechanical stimuli for sound, cochlear development, sensory processing) and membrane ion transport typical of mechanosensory neurons, suggesting a cluster of proteins involved in auditory mechanotransduction and cochlear signaling. ","confidence":"High","size":10,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":4},{"id":"GO:0050910","count":3},{"id":"GO:0007210","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0043200","count":2}]},{"hash":"1977382423501818770","title":"Ubiquitin-Mediated Protein Degradation and Receptor Turnover","description":"This cluster is dominated by ubiquitin-related processes (K48-linked ubiquitination, ERAD, autoubiquitination) and receptor turnover (Wnt receptor catabolic process), pointing to proteostasis and regulation of signaling that can influence organ growth. Some related terms (peroxisome import, glycoprotein catabolism) may reflect broader annotation or secondary targets rather than core functions.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0046621","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0030433","count":5},{"id":"GO:1900095","count":5},{"id":"GO:0070936","count":5}]},{"hash":"1875797629742991412","title":"Unknown","description":"The top GO terms point to plant cell wall modification and plasmodesmata organization, suggesting a plant-specific cell wall theme, but several terms relate to animal development and metabolism (apoptosis, cholesterol metabolism, mammary gland morphogenesis, somite development), giving no single cohesive functional thread across all proteins. Max degree and edges are zero, indicating no interaction pattern to strengthen a function-based label.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":2},{"id":"GO:2001009","count":2},{"id":"GO:0009663","count":2},{"id":"GO:0043654","count":1},{"id":"GO:0015917","count":1}]},{"hash":"1522603228041509211","title":"Proteoglycan and glycosaminoglycan metabolism","description":"The top GO terms cluster around proteoglycan biosynthesis and catabolic processes (keratan sulfate, chondroitin sulfate, and heparan sulfate) as well as related glycosylation and glycosphingolipid metabolism, indicating a core theme of ECM carbohydrate remodeling. The insulin secretion and pancreas development terms add a tissue-context link, but the dominant signal appears to be proteoglycan/glycan metabolism. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042340","count":1},{"id":"GO:0006012","count":1},{"id":"GO:0019388","count":1},{"id":"GO:0006687","count":1},{"id":"GO:0035773","count":1}]},{"hash":"663733036197150218","title":"Neuroimmune Signaling and Axonogenesis","description":"The top GO terms show a mix of immune-related processes (innate immune response, LPS and dsRNA responses, defense against bacteria, interferon-beta production) and neural development/pain-related terms (axonogenesis, corpus callosum development, behavioral response to formalin-induced pain). This pattern suggests a cluster of proteins involved in neuroimmune signaling that intersects neural development and pain pathways, rather than a single, narrow function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0061368","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0014068","count":2}]},{"hash":"497287096319029613","title":"Embryonic Development and Transcriptional Regulation","description":"Top GO terms are dominated by developmental processes (peripheral nervous system neuron development, primitive streak formation) and transcriptional regulation (negative regulation of transcription by RNA polymerase II, histone deacetylation). Additional terms touch on proteostasis, peroxisomal protein import, and cell cycle events, suggesting a broad link to development and gene expression control rather than a single narrowly defined function. This name captures the strongest recurring themes while remaining concise.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048935","count":2},{"id":"GO:0090009","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0034599","count":1},{"id":"GO:0006515","count":1}]},{"hash":"451712550850197497","title":"RTK signaling and actin cytoskeleton dynamics","description":"These proteins cluster around receptor tyrosine kinase\u2013driven signaling (ephrin and neurotrophin TRK pathways) and cytoskeletal regulation (actin binding and localization to actin patches, cell spreading). The combination of tyrosine phosphorylation and RTK signaling with actin remodeling points to RTK-mediated control of the cytoskeleton, with supporting signals from calcium and ER-stress\u2013related translation. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050731","count":2},{"id":"GO:0048013","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0036493","count":1},{"id":"GO:1904427","count":1}]},{"hash":"2027410008468891518","title":"Nitrogen metabolism and amino acid biosynthesis","description":"This cluster centers on nitrogen-related processes (ammonia assimilation, nitrogen fixation, nitrogen starvation) and amino acid biosynthesis (glutamine/glutamate-related), suggesting a cohesive theme around nitrogen management and amino acid metabolism, despite a few outlier terms. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019676","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0010756","count":4},{"id":"GO:0006542","count":4},{"id":"GO:0009399","count":4}]},{"hash":"867473821917464490","title":"Serotonin GPCR Signaling and Sensory Behavior","description":"The cluster\u2019s terms highlight serotonin receptor signaling and G protein-coupled receptor pathways, together with sensory processing and adult walking behavior, pointing to a nervous-system\u2013related function linked to serotonergic signaling and locomotion. Some terms (e.g., prostate development) appear as outliers, but the dominant theme is GPCR-mediated signaling affecting nervous-system\u2013driven behavior.","confidence":"Medium","size":10,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903206","count":1},{"id":"GO:0060742","count":1},{"id":"GO:0060736","count":1},{"id":"GO:0007193","count":1},{"id":"GO:0006665","count":1}]},{"hash":"2287906963558947304","title":"Developmental Regulation with Transporters","description":"The top GO terms cluster around multicellular development, vulval development, sex determination, and cell differentiation, with regulatory signals such as dosage compensation and negative regulation of EGFR signaling, indicating a developmental-regulation theme; a minority of terms point to membrane transport (4-hydroxyphenylacetate transport, vitamin transmembrane transport, sodium ion transmembrane transport, nitrate transmembrane transport), suggesting some transporter functions but not dominating the cluster. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0040027","count":2},{"id":"GO:0030238","count":1},{"id":"GO:0030154","count":1},{"id":"GO:0042464","count":1}]},{"hash":"630482549505706876","title":"Mitochondrial dynamics and associated signaling","description":"The terms cluster around mitochondrial organization, membrane potential regulation, and stress-induced mitochondrial fusion, indicating a core theme of mitochondrial dynamics. Additional terms reference signaling pathways (PKC, TLR3) and cell adhesion/ECM, suggesting broader cellular signaling context but not a single alternative core function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010918","count":1},{"id":"GO:0034141","count":1},{"id":"GO:0007007","count":1},{"id":"GO:0070528","count":1},{"id":"GO:1903905","count":1}]},{"hash":"165609608260951367","title":"Transmembrane Transport of Ions and Small Molecules","description":"Most terms point to transmembrane transport activities, including vitamin, xenobiotic, potassium, and cobalt ion transport, plus related processes like intracellular pH changes. A few terms touch on signaling or metabolism (protein kinase activation, ribosome biogenesis, IL-4 response), but the dominant theme appears to be membrane transport of ions and small molecules.","confidence":"Medium","size":9,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0032147","count":2},{"id":"GO:0042254","count":2}]},{"hash":"813962759184885491","title":"Nuclear RNA Processing and Chromatin Regulation","description":"This cluster centers on nuclear RNA processing (mRNA splicing via spliceosome, spliceosomal complex assembly, mRNA decapping) and chromatin regulation (pericentric heterochromatin formation, histone mRNA metabolism), with supporting processes like nuclear import and cell-cycle transition. Plant-specific signals (response to abscisic acid and water deprivation) may reflect regulation context, but the core theme is RNA processing linked to chromatin dynamics in the nucleus.","confidence":"Medium","size":9,"edges":30,"triangles":49,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0070317","count":2},{"id":"GO:0051170","count":2},{"id":"GO:0030490","count":2},{"id":"GO:0000290","count":2}]},{"hash":"2145354229880811309","title":"Renal epithelial differentiation (podocyte & nephron)","description":"The cluster\u2019s GO terms predominantly point to differentiation of renal epithelial cells, including podocytes, nephron tubule epithelium, and glomerular parietal cells, indicating a shared role in kidney development and cell fate specification. Some terms about endocytosis regulation and a few unrelated photoreceptor-related terms are present, but the kidney differentiation signal is strongest.","confidence":"Medium","size":9,"edges":20,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048550","count":1},{"id":"GO:0072112","count":1},{"id":"GO:2000768","count":1},{"id":"GO:0072139","count":1},{"id":"GO:2001287","count":1}]},{"hash":"1200174395689264720","title":"Aminoacyl-tRNA Synthetases","description":"The top GO terms are dominated by specific aminoacyl-tRNA synthetases (isoleucyl-, valyl-, leucyl-, methionyl-, cysteinyl-tRNA synthetases) and translation, indicating these proteins function in charging tRNAs for protein synthesis. The presence of translational fidelity regulation reinforces a translation-focused cluster, while unrelated terms like endothelial activation and lipid transport may reflect broader annotations but do not override the core signal.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006428","count":2},{"id":"GO:0006438","count":2},{"id":"GO:0006429","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006431","count":2}]},{"hash":"1442763875292284518","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000472","count":7},{"id":"GO:0000463","count":7},{"id":"GO:0000398","count":7},{"id":"GO:0000462","count":7},{"id":"GO:0000480","count":7}]},{"hash":"189918323743350038","title":"Development and Cell Cycle Regulation","description":"This cluster is driven by core growth and division processes: DNA replication, mitotic cell cycle, and DNA-templated transcription, along with development-related terms like multicellular organism development, angiogenesis, and axonogenesis. While a couple of outlier terms (defense response to Gram-positive bacteria and abscisic acid signaling) appear, the dominant theme ties together cellular proliferation with developmental programs, suggesting a cohesive role in growth and differentiation.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0001525","count":5},{"id":"GO:0007409","count":5}]},{"hash":"1126178294649078070","title":"ncRNA-regulated spliceosome splicing","description":"The strongest terms are regulatory ncRNA-mediated gene silencing and spliceosome-based mRNA splicing, with multiple entries for positive regulation of splicing via the spliceosome. This points to a cohesive theme of RNA processing and ncRNA-driven regulation, with a few outliers related to stress or learning that are likely secondary noise.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1795420416815720986","title":"Membrane Transporters (Nutrients and Xenobiotics)","description":"The cluster shows a consistent theme of transmembrane transport across the plasma membrane for diverse substrates (vitamins, sugars, ions, nitrate, xenobiotics, trehalose, etc.), along with an osmotic stress response connection. This suggests a group of broad-specificity transport proteins rather than a single substrate, hence a membrane transporter-centric label.","confidence":"High","size":9,"edges":16,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":9},{"id":"GO:0006855","count":9},{"id":"GO:0042891","count":9},{"id":"GO:1900754","count":7},{"id":"GO:0035725","count":7}]},{"hash":"431523199841647918","title":"Plant secondary metabolism and cell wall biosynthesis","description":"This cluster is enriched for lignin metabolism, cell wall organization, and cyanidin glycoside (anthocyanin) biosynthesis, pointing to phenylpropanoid-derived pathways involved in cell wall construction and pigment production. Some antibiotic response and carbohydrate metabolism terms may reflect defense-related metabolic activity; overall, the dominant signal is plant secondary metabolism linked to cell wall formation and pigment biosynthesis.","confidence":"High","size":9,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0042572","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0071555","count":3},{"id":"GO:0019518","count":3}]},{"hash":"1986409403858978328","title":"Ribosome biogenesis and translation initiation","description":"The terms cluster around preribosome assembly, LSU rRNA maturation, and large subunit assembly, plus regulation and formation of translation preinitiation complexes, with related translation initiation/reinitiation terms. This points to a cohesive function in ribosome production and initiation control, justifying a label focused on ribosome biogenesis and translation initiation.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":3},{"id":"GO:1902626","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0075522","count":2}]},{"hash":"1535449112002636488","title":"Bacterial envelope biosynthesis and metal transport","description":"Top GO terms strongly cluster around envelope-related biosynthesis (lipopolysaccharide biosynthetic process; cell wall organization) and metal ion transport (cadmium and copper). The presence of broader metabolism terms such as carbohydrate and L-serine biosynthesis suggests accompanying metabolic activities, typical of bacteria coordinating envelope assembly with metabolic and transport functions. Overall, the cluster appears to reflect bacterial envelope biogenesis integrated with metabolic and metal transport processes.","confidence":"Medium","size":9,"edges":4,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009103","count":4},{"id":"GO:0005975","count":4},{"id":"GO:0071555","count":4},{"id":"GO:0046839","count":3},{"id":"GO:0006564","count":3}]},{"hash":"642857494513728932","title":"Membrane Transporters","description":"The top GO terms all point to transmembrane transport of a variety of substrates\u2014ions (K+, Na+), vitamins, glucose, trehalose, and xenobiotics\u2014indicating these proteins function collectively as membrane transporters that move diverse compounds across cellular membranes. This cohesive transport theme best fits the cluster\u2019s function.","confidence":"High","size":9,"edges":32,"triangles":59,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":9},{"id":"GO:0035461","count":9},{"id":"GO:0042908","count":9},{"id":"GO:0006855","count":9},{"id":"GO:1900754","count":8}]},{"hash":"1403622999755824243","title":"Multitissue Development and Cell Adhesion","description":"The terms cluster around development across multiple tissues (pituitary gland, cerebral cortex, inner ear, skeletal muscle) and neural-muscle connectivity (motor neuron axon guidance, cell-matrix adhesion), with supporting processes like cell size regulation. Some terms (sperm capacitation) appear outliers, but the dominant signal points to broad developmental patterning and adhesion-related functions, justifying a multitissue development label.","confidence":"Medium","size":9,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045793","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0045454","count":2}]},{"hash":"4037641979274180","title":"Sugar Alcohol and Fatty Acid Metabolism","description":"This cluster shows GO terms including fatty acid biosynthetic process and several sugar/alcohol catabolic processes (D-sorbitol, xylitol, fructose biosynthesis), indicating a metabolic module focused on carbohydrate and lipid metabolism. A few terms (e.g., extracellular negative regulation of signal transduction) seem less related and may reflect annotation noise, but the dominant theme is metabolic pathways.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":3},{"id":"GO:0019595","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0006116","count":2},{"id":"GO:0006062","count":2}]},{"hash":"1180586961435167468","title":"Stress and Growth Response","description":"The terms include cellular responses to insulin and lipopolysaccharide, response to oxidative stress and toxins, amino acid signaling, organ regeneration, and regulation of growth, along with modulation of NF-kappaB signaling. This mix points to a broad network of cellular stress/adaptation and growth signaling rather than a single, cohesive pathway, so the label emphasizes a general stress-growth response.","confidence":"Medium","size":9,"edges":18,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":4},{"id":"GO:0071222","count":3},{"id":"GO:0033591","count":3},{"id":"GO:0031100","count":3},{"id":"GO:0040008","count":3}]},{"hash":"1336925765400698269","title":"Plant Cell Wall Cellulose Biosynthesis","description":"The top GO terms point to cellulose biosynthesis in the plant-type cell wall, suggesting the proteins contribute to plant cell wall synthesis. The presence of both biosynthetic and regulatory terms around this process supports a cohesive plant cell-wall\u2013related function.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2001009","count":1},{"id":"GO:0052324","count":1}]},{"hash":"1116999126841850084","title":"DNA Replication and Transcription Regulation","description":"The terms center on DNA replication, transcription initiation/regulation (RNA Pol II), and chromatin assembly, with related RNA processing and decay processes. This points to a cohesive theme of genome expression control and chromatin dynamics, even though some developmental GO terms appear alongside. ","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0000436","count":2},{"id":"GO:0045898","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0035264","count":2}]},{"hash":"2254725664975313481","title":"Actin cytoskeleton dynamics","description":"Based on the top GO terms, especially negative regulation of actin filament depolymerization and actomyosin structure organization, the cluster appears enriched for proteins involved in remodeling the actin cytoskeleton. While several development-related terms are also present, the shared theme is cytoskeleton remodeling rather than a single tissue-specific function.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035195","count":5},{"id":"GO:0035852","count":5},{"id":"GO:0001705","count":5},{"id":"GO:0060067","count":5},{"id":"GO:0030835","count":5}]},{"hash":"1229831944712647409","title":"Unknown","description":"GO terms span nitrogen metabolism, serine biosynthesis, miRNA silencing, several signaling pathways, and diverse developmental processes, with no single shared function tying all proteins.","confidence":"","size":9,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006808","count":3},{"id":"GO:0006564","count":2},{"id":"GO:0035195","count":2},{"id":"GO:0008588","count":2},{"id":"GO:0035995","count":2}]},{"hash":"1387424950997553137","title":"Nervous system signaling and sensory perception","description":"This cluster is dominated by GO terms related to sensory perception (pain, vision), visual learning, and dopaminergic synaptic transmission, along with behavioral responses to cocaine and ERK signaling. Together these suggest a core theme of neural signaling and sensory processing, even though a few terms point to development or inflammatory processes as potential pleiotropic roles. Therefore, the label reflects the strongest, most coherent function among the terms.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0070374","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0001963","count":3}]},{"hash":"68749031972379376","title":"Membrane Transporters","description":"This cluster is dominated by diverse transmembrane transport GO terms for many solutes (sugars, vitamins, nitrate, phosphate, sodium, xenobiotics) and even neurotransmitter loading into synaptic vesicles, pointing to a cohesive group of membrane transporter proteins that move substances across membranes.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0015751","count":4},{"id":"GO:0015706","count":4}]},{"hash":"2156224292764600846","title":"Meiotic DSB Repair","description":"The top GO terms center on meiotic double-strand break formation and repair (recombination-related DSB processing), suggesting the cluster represents proteins involved in meiotic recombination and DNA repair. Some other terms appear unrelated noise (lung development, proteolysis, calcium detection, transcription termination, signaling), but the meiotic DSB theme is the strongest signal.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0005513","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0010780","count":2}]},{"hash":"577707896670464129","title":"Nematode Development and Reproduction","description":"Proteins show a convergence on developmental and reproductive biology, including embryogenesis (maternal axis specification, morphogenesis), fertilization-associated processes (polyspermy prevention, regulation of sperm binding), and nematode-specific physiology (cuticle molting, pharyngeal pumping), suggesting a cohesive nematode development/reproduction function cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":1},{"id":"GO:0060468","count":1},{"id":"GO:0007313","count":1},{"id":"GO:0035124","count":1},{"id":"GO:0048632","count":1}]},{"hash":"1771995205222736396","title":"TNF-NF-kappaB Signaling and Ubiquitination","description":"The strongest signals are TNF-mediated signaling and NF-kappaB activation (GO:0033209, GO:0007250), pointing to TNF-driven NF-kappaB pathway activity. The presence of ubiquitin-related terms (K63- and K48-linked ubiquitination) supports ubiquitin-dependent regulation of signaling and protein turnover, a hallmark of NF-kappaB pathway control. While other terms touch on LPS signaling, chemokine production, and other immune-related processes, they appear as supportive context rather than core themes. Thus, the cluster centers on TNF/NF-kappaB signaling modulated by ubiquitination.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":4},{"id":"GO:0007250","count":4},{"id":"GO:0070534","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0070936","count":2}]},{"hash":"1635620923390186584","title":"Unknown","description":"The top GO terms mix plant-specific processes (cell wall modification, plasmodesma organization) with animal development signals (Notch signaling, ovarian follicle development, B cell differentiation) and contain obsolete terms, indicating no cohesive single function or pathway characterizes this cluster.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":3},{"id":"GO:2001009","count":3},{"id":"GO:0009663","count":3},{"id":"GO:0007143","count":2},{"id":"GO:0032092","count":2}]},{"hash":"2194778239117900518","title":"P450-driven steroidogenesis and xenobiotic metabolism","description":"The top GO terms point to cytochrome P450\u2013mediated processes: epoxygenase P450 pathways, multiple steroid biosynthesis (cortisol, testosterone, aldosterone, progesterone), and xenobiotic/detoxification activities (insecticide metabolism, oxidative deethylation). Uterus development and inflammatory regulation can be linked to hormone-driven developmental and immune modulation. Together they describe a cluster centered on P450 enzymes coordinating steroid production and xenobiotic metabolism.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019373","count":9},{"id":"GO:0033072","count":8},{"id":"GO:0034651","count":8},{"id":"GO:0061370","count":8},{"id":"GO:0032342","count":8}]},{"hash":"847286415974988095","title":"Lipid droplet dynamics and triglyceride metabolism","description":"The set is dominated by terms related to lipid droplets and triglyceride management, including triglyceride mobilization, lipid droplet localization and transport, and negative regulation of fatty acid beta-oxidation, pointing to a cohesive theme of lipid storage and mobilization. While BMP signaling and intestinal stem cell homeostasis appear, the strongest signal is lipid droplet regulation, making this a coherent cluster for lipid storage/metabolism processes.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070236","count":3},{"id":"GO:0008101","count":3},{"id":"GO:0048642","count":3},{"id":"GO:0036335","count":3},{"id":"GO:2000378","count":1}]},{"hash":"2001997744453355436","title":"Steroid Hormone Biosynthesis and Regulation","description":"The cluster is dominated by steroid-related biosynthetic and metabolic processes (cortisol, testosterone, aldosterone, progesterone) and hormone-regulated traits (brassinosteroid homeostasis, uterus development), pointing to a coherent theme of steroid hormone production and hormonal control; a couple of unrelated terms appear but do not overturn the overall signal.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033072","count":9},{"id":"GO:0034651","count":9},{"id":"GO:0061370","count":9},{"id":"GO:0032342","count":9},{"id":"GO:0017143","count":9}]},{"hash":"1000497856548373646","title":"Lung branching morphogenesis and ECM remodeling","description":"The top GO terms cluster around lung development and morphogenesis (lung branching, epithelial tube branching) as well as extracellular matrix remodeling (basement membrane disassembly, collagen catabolic process, bone resorption). Although there are a few outliers related to catabolic processes in other contexts, the dominant signal ties to lung morphogenesis and ECM turnover, suggesting proteins involved in shaping airways and remodeling surrounding matrices. Confidence: High","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":3},{"id":"GO:0034769","count":3},{"id":"GO:0051603","count":3},{"id":"GO:0001913","count":3},{"id":"GO:0030574","count":3}]},{"hash":"656391806376990117","title":"Unknown","description":"The top GO terms cover mitochondrial electron transport, general transport, peroxisome autophagy, several bacterial biosynthetic processes, amino acid metabolism, and stress responses, with no clear shared function or interaction pattern (Edges 0). This heterogeneity makes it unclear how the proteins function together as a single theme, so Unknown is the most appropriate label.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0006810","count":1},{"id":"GO:0030242","count":1},{"id":"GO:0050826","count":1},{"id":"GO:0006541","count":1}]},{"hash":"1684832339161116776","title":"Unknown","description":"The terms are highly diverse: olfactory behavior and chemical stimulus detection suggest sensory roles, but others point to cytoskeletal organization, development-related signaling, epithelial differentiation, immune regulation, and vascular processes. With no dominant shared function and no edges linking the proteins, there is no cohesive theme to name the cluster beyond Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042048","count":1},{"id":"GO:0050907","count":1},{"id":"GO:0031032","count":1},{"id":"GO:0050765","count":1},{"id":"GO:1904706","count":1}]},{"hash":"676708244702535410","title":"DNA Damage Response and Meiotic Signaling","description":"The top GO terms point to DNA replication, lesion tolerance (translesion synthesis), PARylation, and ubiquitin-mediated degradation, all tied to DNA damage response and repair. Additional terms emphasize transcriptional regulation following damage and meiosis-specific processes (meiotic recombination checkpoint signaling, synaptonemal complex assembly). One term about neuron axonogenesis seems ancillary, but the core theme is DNA damage response/repair coupled with meiotic signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042276","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0070212","count":2},{"id":"GO:0021952","count":2},{"id":"GO:0051598","count":1}]},{"hash":"692611183864409139","title":"Unknown","description":"Top GO terms span bacterial antigen biosynthesis, LPS response, TNF and NF-kB signaling, apoptosis, plant defense regulation, and even neuromuscular transmission, indicating a mixed, cross-kingdom set of functions with no single cohesive theme. Because there is no unified biological function tying these nine proteins together, a concise label cannot be confidently assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":2},{"id":"GO:0019310","count":1},{"id":"GO:0019853","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0042771","count":1}]},{"hash":"1523708732751649486","title":"Meiosis I spindle assembly and oocyte maturation","description":"Multiple terms point to meiosis/oocyte biology: spindle assembly in female meiosis I, oocyte maturation, and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (cell cycle control). While there are also neural development terms and general microtubule polymerization, the strongest, more specific theme is meiosis-related processes, particularly spindle assembly and oocyte maturation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0021678","count":2},{"id":"GO:0021993","count":2},{"id":"GO:0070544","count":2}]},{"hash":"263408319321941771","title":"Neural Signaling and Sensory Processing","description":"In this cluster, most GO terms point to neuronal signaling and sensory functions \u2014 synaptic depression regulation, Purkinje cell action potential, pain detection, thermosensory behavior, and optic nerve organization \u2014 with ion transport supporting neuronal excitability. Some terms (cortisol biosynthesis, T cell homeostasis, inositol phosphate signaling) are peripheral noise, but overall the cluster centers on neural signaling and sensory processing.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1900454","count":1},{"id":"GO:0034651","count":1},{"id":"GO:0086047","count":1},{"id":"GO:0048016","count":1},{"id":"GO:0071805","count":1}]},{"hash":"549622377969873167","title":"Drosophila egg-laying and mating behavior regulation","description":"The dominant GO terms center on regulation of egg-laying behavior, including positive/negative regulation and post-mating receptivity, plus related behavioral activities like larval locomotion and behavioral defense. This points to a cohesive theme of reproductive and behavioral modulation in insects, with additional signaling terms (e.g., GTPase activity, opioid receptor signaling) likely reflecting underlying regulatory pathways. Some terms (electronic transport chain, vasodilation) may be ancillary annotations, but the core cluster clearly aligns with reproductive/behavioral regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048042","count":4},{"id":"GO:0045434","count":4},{"id":"GO:0008345","count":4},{"id":"GO:0002209","count":4},{"id":"GO:1901045","count":4}]},{"hash":"734825296754241645","title":"Unknown","description":"This cluster has no edges or GO term signals to unify a shared function, and Top Terms are empty, so there is no identifiable common theme among the proteins to assign a meaningful label. Confidence: None.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"202389753316527905","title":"Developmental gene regulation","description":"This cluster appears to center on development and regulation of gene expression across tissues, with terms spanning multicellular growth and organ-specific differentiation (prostate, brain, gonads) plus transcriptional and RNA/translation control, and cell cycle regulation. While the proteins are not connected by a single pathway, the common theme is regulatory roles in development and gene expression.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":4},{"id":"GO:0060528","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0007420","count":3}]},{"hash":"700940290084937353","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0046784","count":3},{"id":"GO:0002188","count":3}]},{"hash":"1741719330454539570","title":"DNA Replication and Proliferation Control","description":"The GO terms are dominated by DNA replication and transcription activities, coupled with regulation of cell proliferation and apoptosis, and supported by cell migration and development signals. This points to a core theme of growth, survival, and tissue remodeling, with additional stress-related responses that intersect with proliferation. ","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:2000251","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0090090","count":2}]},{"hash":"1671417628103358841","title":"Cytoskeleton dynamics and ER-Golgi transport","description":"The Top Terms cluster around cytoskeleton-based processes (mitotic spindle assembly, establishment or maintenance of cell polarity affecting shape) and vesicle trafficking from the endoplasmic reticulum to the Golgi, plus related remodeling and autophagy (reticulophagy). Although some terms reflect organism-specific roles (substantia nigra development, ascospore formation), the dominant theme ties to cytoskeletal dynamics and intracellular transport, suggesting these proteins function together in structural organization and vesicle movement.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0071963","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0021762","count":3}]},{"hash":"145668545591082552","title":"Mitotic cycle and transcriptional signaling","description":"The strongest signals are DNA-templated transcription, DNA replication, mitotic cell cycle, and centrosome cycle, pointing to a core theme of cell-cycle control and transcriptional regulation. Additional terms like insulin receptor signaling and axonogenesis/chemotaxis suggest broader growth and migratory signaling layered on this core. Overall, the dominant pattern reflects cell-cycle\u2013related transcriptional regulation with growth signaling.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007098","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0007409","count":3}]},{"hash":"2097150907329902572","title":"ER stress and unfolded protein response","description":"This cluster features several GO terms tied to proteostasis under stress, including cellular response to unfolded protein, ER stress-induced apoptotic signaling regulation, negative regulation of intrinsic apoptotic signaling in response to hydrogen peroxide, and chaperone/cofactor-dependent protein refolding. Together these point to a coherent theme of ER stress management and unfolded protein response, i.e., maintaining protein folding homeostasis during cellular stress. Some terms like fungal-type beta-glucan biosynthetic process or karyogamy appear unrelated to proteostasis and likely reflect annotation noise or distant homologs, but the dominant signal is proteostasis and stress signaling. Therefore the label ER stress and unfolded protein response is appropriate.","confidence":"Medium","size":8,"edges":11,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007403","count":2},{"id":"GO:1903382","count":1},{"id":"GO:1903751","count":1},{"id":"GO:0070880","count":1},{"id":"GO:0090084","count":1}]},{"hash":"1142974056986790009","title":"GPCR-coupled adenylate cyclase signaling","description":"This cluster shows strong representation of GPCR signaling pathways that regulate adenylate cyclase activity (both activation and inhibition) across multiple receptor types (dopamine, adenosine, adrenergic, opioid) with related downstream effects such as prostaglandin responses and vascular regulation, indicating a cohesive cAMP-mediated signaling theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007195","count":6},{"id":"GO:0001973","count":6},{"id":"GO:0071880","count":6},{"id":"GO:0007190","count":6},{"id":"GO:0071380","count":6}]},{"hash":"754579464189787711","title":"Neuromuscular development and synaptic signaling","description":"This cluster prominently features terms related to nerve and Schwann cell development (axonogenesis, Schwann cell development), muscle development and activity (myoblast fusion, response to muscle activity), and synaptic function (long-term potentiation, excitatory postsynaptic potential), suggesting a cohesive theme of neuromuscular development and synaptic signaling. Some terms (angiogenesis, cell cycle) appear less connected but do not outweigh the dominant neuromuscular/synaptic pattern.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0007520","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0014044","count":2}]},{"hash":"436143747828438121","title":"Unknown","description":"Top terms are diverse (translation, lipid biosynthesis, differentiation, cytoskeletal regulation, energy metabolism), with no clear shared function or network connectivity. The lack of cohesive theme suggests no single label fits well.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0051496","count":2},{"id":"GO:0002071","count":1},{"id":"GO:0036149","count":1}]},{"hash":"276253210494680439","title":"Post-transcriptional mRNA processing and translation control","description":"The top GO terms cluster around post-transcriptional processes: mRNA export, splicing, modification, stability, poly(A) tail regulation, and translation initiation/reinitiation (including IRES-dependent translation). This combination points to proteins involved in regulating mRNA fate after transcription, rather than a single biochemical pathway, justifying a label focused on post-transcriptional mRNA regulation.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902625","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001825","count":2},{"id":"GO:0010610","count":2},{"id":"GO:1903586","count":2}]},{"hash":"468826504176424327","title":"Unknown","description":"The GO terms appear highly heterogeneous, ranging from translation machinery to immune cell chemotaxis and differentiation, with no single shared function linking all proteins; thus there is no clear representative theme for the cluster.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001732","count":1},{"id":"GO:0006413","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0045445","count":1},{"id":"GO:0006259","count":1}]},{"hash":"2213786880613798833","title":"GPCR and GTPase signaling during development","description":"This cluster centers on signaling networks that govern development and cellular communication, highlighted by acetylcholine GPCR signaling and Rho/small GTPase pathways, along with calcium-dependent exocytosis. The presence of nervous system, heart, and skeletal development terms suggests a cohesive theme of developmental signaling affecting neuronal and cardiac function, with mitochondrial fission reflecting broader cellular dynamics linked to these processes.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0007213","count":3},{"id":"GO:0001302","count":3},{"id":"GO:0000266","count":3},{"id":"GO:0045956","count":3}]},{"hash":"1026050315898372380","title":"Developmental Transcription Regulation","description":"The cluster features multiple terms tied to transcriptional control (RNA polymerase II transcription, regulation of DNA-templated transcription) and developmental processes such as anterior/posterior axis specification and limb development, suggesting a theme around gene regulation during development. Some meiosis-related terms are present but do not form a cohesive core, so the overall signal points to developmental transcriptional regulation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045144","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0008595","count":1},{"id":"GO:0006311","count":1},{"id":"GO:0007406","count":1}]},{"hash":"2269807817907553989","title":"Growth hormone and insulin signaling with stress responses","description":"The terms cluster around hormone signaling (growth hormone receptor signaling, regulation of insulin receptor signaling, and STAT phosphorylation) and responses to stimuli (peptide hormones, wounding, LPS, and angiogenesis). While DNA replication and apoptotic process are present, the dominant pattern is signaling pathways tied to hormone responses and stress/inflammatory stimuli.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0071375","count":3},{"id":"GO:0009611","count":3},{"id":"GO:0060396","count":3}]},{"hash":"259795909075568019","title":"Glycan biosynthesis and cell-surface morphogenesis","description":"This cluster aggregates GO terms tied to glycan production and modification (poly-N-acetyllactosamine biosynthesis, O-linked glycosylation via hydroxyproline, arabinogalactan protein metabolism) together with cell-surface and adhesion-related processes (follicle epithelium polarity maintenance, cell adhesion) and various developmental contexts (root hair development, insect visual primordium formation, seed mucilage formation). This suggests a cohesive theme around glycoprotein glycosylation shaping cell surfaces and morphogenesis across species.","confidence":"Medium","size":8,"edges":14,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042248","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0007299","count":3},{"id":"GO:0048354","count":3},{"id":"GO:0010405","count":3}]},{"hash":"1530405447982503044","title":"Embryonic and Cardiac Morphogenesis","description":"The most frequent GO terms point to morphogenesis and development, especially heart/cardiac muscle and ventricular morphogenesis, alongside embryonic development and organ-specific morphogenesis (eye, thymus, ovary). This suggests a cluster of proteins involved in developmental morphogenesis across tissues.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060528","count":2},{"id":"GO:0001547","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0055010","count":2},{"id":"GO:0048048","count":2}]},{"hash":"2060115792433137656","title":"Neural protein processing and APP metabolism","description":"GO terms cluster around neuronal protein handling (protein quality control for misfolded proteins; glycoprotein catabolic and deglycosylation processes) together with amyloid precursor protein metabolic process, and neural-context terms like positive regulation of protein localization to synapse and retina development. This suggests a theme of neuronal protein processing and APP-related metabolism, with some peripheral lipid catabolic signals. Overall, the label captures the central neural protein-processing functions represented in the cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016042","count":3},{"id":"GO:0006515","count":2},{"id":"GO:0006516","count":2},{"id":"GO:0006517","count":2},{"id":"GO:0048671","count":2}]},{"hash":"1482915767588480806","title":"Embryonic Organ Morphogenesis","description":"This cluster centers on development and morphogenesis across multiple organs (heart, eye, inner ear, ovary, prostate) and embryogenesis in general, with some transcriptional regulation terms. The dominant GO terms point to organogenesis and tissue shaping, suggesting these proteins work together in embryonic development rather than a single pathway. Overall, the theme is developmental morphogenesis across diverse tissues.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055010","count":4},{"id":"GO:0060528","count":3},{"id":"GO:0001547","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0048048","count":3}]},{"hash":"25618724110954275","title":"Translation and SRP-mediated protein targeting","description":"This cluster has strong enrichment for translation (GO:0006412) with two instances and for SRP-dependent cotranslational protein targeting to membrane (GO:0006614), indicating a shared function around ribosome-associated protein synthesis and targeting to membranes. Other terms are more sporadic (e.g., cobalamin biosynthesis, pentose phosphate shunt), so the translation/targeting theme best fits the group.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0019323","count":1},{"id":"GO:0009052","count":1},{"id":"GO:0006098","count":1}]},{"hash":"349566181637091154","title":"Translation machinery and fidelity","description":"This cluster is dominated by translation-related terms: translation (GO:0006412), translational termination, and ribosomal large subunit assembly, along with maintenance/regulation of translational fidelity. A smaller subset refers to antibiotic response and stringent response, which can accompany translation under stress, but the prevailing theme is ribosome function and protein synthesis quality control.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006415","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0046677","count":2},{"id":"GO:1990145","count":2}]},{"hash":"2274863214912876993","title":"Proteoglycan Biosynthesis in Tissue Morphogenesis","description":"This cluster is dominated by GO terms for proteoglycan biosynthesis (chondroitin sulfate, heparan sulfate, proteoglycans) and related glycosylation processes, plus UDP-D-xylose metabolism, which points to the extracellular matrix synthesis pathways. The inclusion of tissue morphogenesis and cell adhesion molecule production supports a role in ECM remodeling during development. Some terms like intestinal absorption and thyroid metabolism are less central, but the core signal is proteoglycan biosynthesis tied to tissue formation.","confidence":"High","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048729","count":2},{"id":"GO:0050650","count":2},{"id":"GO:0015012","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0060352","count":2}]},{"hash":"152714451838092563","title":"Clathrin-mediated endocytosis and epithelial cell polarity","description":"Top terms center on clathrin-dependent endocytosis and GPCR internalization, with strong signals for epithelial polarity (apical/basal), planar polarity, and related polarity protein localization, suggesting a trafficking-driven polarity cluster.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072583","count":2},{"id":"GO:0002031","count":2},{"id":"GO:0008631","count":1},{"id":"GO:0090176","count":1},{"id":"GO:0051663","count":1}]},{"hash":"1620094811776286250","title":"Embryonic organ morphogenesis and germline development","description":"The terms cluster around developmental processes across multiple tissues (ureter morphogenesis, nephron tubule formation, neural crest migration, lens/photoreceptor differentiation) and germ line biology (meiotic division, germ-line sex determination), suggesting a theme of embryonic organogenesis and germ cell development, with a few outliers related to immune responses. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072197","count":1},{"id":"GO:0007140","count":1},{"id":"GO:0046533","count":1},{"id":"GO:0035711","count":1},{"id":"GO:0071504","count":1}]},{"hash":"863138593365679098","title":"Lipid and isoprenoid biosynthesis","description":"The top GO terms cluster around lipid and isoprenoid-derived metabolism: fatty acid elongation and very long-chain fatty acid biosynthesis; testosterone (steroid) biosynthesis; retinoic acid biosynthesis; phylloquinone metabolism (an isoprenoid quinone); and poly-hydroxybutyrate biosynthesis. These collectively point to lipid/isoprenoid biosynthetic pathways, with some drug-response terms present as ancillary annotations. Overall, a cohesive theme is lipid- and isoprenoid-derived metabolite biosynthesis. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0042619","count":5},{"id":"GO:0031427","count":4},{"id":"GO:0042761","count":4},{"id":"GO:0030497","count":4}]},{"hash":"1397654966646054328","title":"Endochondral Ossification and Cartilage ECM Remodeling","description":"This cluster is driven by terms for cartilage development, endochondral ossification, collagen fibril organization, and collagen catabolic processes, plus integrin biosynthesis, all pointing to extracellular matrix remodeling in bone/cartilage formation. A couple terms touch on unrelated areas (lipoprotein clearance, podocyte development, myeloid apoptotic regulation), but the dominant pattern is cartilage/bone ECM remodeling.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":1},{"id":"GO:0033034","count":1},{"id":"GO:0060351","count":1},{"id":"GO:0045112","count":1},{"id":"GO:0001958","count":1}]},{"hash":"1525081287820338050","title":"Neural signaling and autonomic vascular regulation","description":"The GO terms cluster around neuronal signaling and sensory/temperature responses, including membrane potential regulation and opioid signaling, plus interneuron development, with additional links to autonomic vasodilation (norepinephrine/angiotensin) and energy metabolism, suggesting a brain-centered neural-vascular-metabolic module. ","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0042391","count":6},{"id":"GO:0031635","count":5}]},{"hash":"1715314743984504148","title":"Unknown","description":"The terms span neural signaling, muscle physiology, ion transport, endocrine biosynthesis, and immune homeostasis with no clear shared function tying them together, and each term appears only once. This suggests no coherent, single biological theme for the cluster, so a specific label cannot be confidently assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900454","count":1},{"id":"GO:0034651","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0045214","count":1},{"id":"GO:0086047","count":1}]},{"hash":"1415869769163371500","title":"Cerebellar glial development and neural signaling","description":"This cluster centers on neural development and glial differentiation in the cerebellum, with terms like cerebellar cortex formation, Bergmann glial cell differentiation, Schwann cell development, and regulation of axon regeneration, plus insulin signaling. The presence of broader terms such as T cell signaling and cocaine response suggests additional, non-specific associations, but the core signal points to cerebellar glial/neural development and related signaling pathways.","confidence":"Medium","size":8,"edges":19,"triangles":22,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2001275","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0021697","count":5},{"id":"GO:0008286","count":5},{"id":"GO:0048679","count":5}]},{"hash":"1714184743274506407","title":"Insect reproductive and larval behavior regulation","description":"The top GO terms are dominated by behavioral regulation in insects, especially negative regulation of female receptivity post-mating, regulation of egg-laying behavior, and larval locomotory behavior, with an additional behavioral defense term. A few plant-cell-wall related terms appear as outliers, but the prevailing theme points to regulation of insect reproduction and larval behavior.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045434","count":3},{"id":"GO:0048042","count":3},{"id":"GO:0002209","count":3},{"id":"GO:1901045","count":3},{"id":"GO:0008345","count":3}]},{"hash":"129801161599022477","title":"Potassium Ion Transport and Membrane Potential Regulation","description":"The proteins show strong enrichment for potassium ion transport across membranes (export/import/transmembrane transport), intracellular potassium homeostasis, and membrane potential stabilization/depolarization, including a term tied to Purkinje neuron action potentials. This points to a coherent theme of potassium handling and neuronal excitability, with a couple outliers (cortisol biosynthesis) that are less central. Overall, the cluster most likely reflects potassium transport and neuronal membrane potential regulation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097623","count":4},{"id":"GO:0030007","count":4},{"id":"GO:1990573","count":4},{"id":"GO:0030322","count":4},{"id":"GO:1900454","count":3}]},{"hash":"562499580562401505","title":"Neurotransmitter GPCR signaling and vascular regulation","description":"The top GO terms point to various neurotransmitter signaling pathways (dopamine, octopamine/tyramine, opioid receptor signaling) and vasodilation mechanisms (norepinephrine/epinephrine- and angiotensin-mediated), plus related neuronal development (cerebral cortex interneuron migration) and heart morphogenesis. This suggests a theme centered on neural signaling that modulates vascular tone and cardiovascular development, with a few broader cellular processes included. Confidence: Medium","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007606","count":2},{"id":"GO:0031635","count":1},{"id":"GO:0008284","count":1},{"id":"GO:0002025","count":1},{"id":"GO:0022900","count":1}]},{"hash":"965486075237794286","title":"Cartilage and bone ECM remodeling","description":"This cluster is enriched for cartilage development, endochondral ossification, and collagen-related processes, with several terms pointing to extracellular matrix organization and integrin-mediated assembly\u2014hallmarks of skeletal connective tissue development. Some peripheral terms (lipoprotein clearance, podocyte development, PDGF signaling) are less central but do not override the core ECM/bone-cartilage theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0033034","count":3},{"id":"GO:0060351","count":3},{"id":"GO:0045112","count":3},{"id":"GO:0001958","count":3}]},{"hash":"1183597024748666587","title":"Immune Cell Chemotaxis and Antiviral Response","description":"Most terms point to leukocyte recruitment (macrophage, monocyte, eosinophil chemotaxis) and antiviral/host responses (cellular response to virus, regulation of viral entry into host cell). There are also immune-regulatory signals affecting T cells, suggesting a broader immune-focus. Some outlier terms (myoblast differentiation, DNA metabolism) appear less related but do not override the prevailing immune theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098586","count":3},{"id":"GO:0045445","count":2},{"id":"GO:0006259","count":2},{"id":"GO:0018258","count":2},{"id":"GO:0048246","count":2}]},{"hash":"1687775572927760362","title":"Oxidative Stress Response and Growth Regulation","description":"The proteins in this cluster show enrichment for detoxification of oxidants and response to antioxidants (e.g., response to L-ascorbic acid, cellular oxidant detoxification, toxin catabolic process) along with processes that regulate growth and regeneration (regulation of growth, animal organ regeneration, vascular smooth muscle proliferation). Some terms like sensory perception of smell and NF-kappaB regulation are broader or context-specific, but the dominant pattern supports a theme of oxidative stress defense coupled with growth/repair modulation.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033591","count":4},{"id":"GO:0031100","count":4},{"id":"GO:0040008","count":4},{"id":"GO:0060316","count":4},{"id":"GO:0098869","count":4}]},{"hash":"877019859598268981","title":"Unknown","description":"The top GO terms are highly diverse, including fungal ascospore formation, neural processes (myelination and neuron projection extension), and multiple metabolic pathways (thiamine, beta-alanine, halogen metabolism, amino acid catabolic processes, and dopamine catabolic processes). With no edges among proteins (Edges: 0, Triangles: 0, Max Degree: 0), there is no clear shared function tying these proteins together, suggesting a heterogeneous or mis-clustered grouping. Therefore, there is no coherent label beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":2},{"id":"GO:0030437","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0009228","count":1},{"id":"GO:1990138","count":1}]},{"hash":"70840478048217810","title":"Cartilage Development and ECM Remodeling","description":"The cluster's GO terms cluster around cartilage development and endochondral ossification, collagen fibril organization and catabolic processes, and integrin biosynthetic processes\u2014key aspects of extracellular matrix (ECM) assembly and remodeling necessary for skeletal tissue formation. Additional terms touch on podocyte development and regulation of PDGF receptor signaling, which can involve ECM interactions and signaling cross-talk. Taken together, the data point to a theme of cartilage/ossification and ECM organization.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0001958","count":2}]},{"hash":"240373487539818115","title":"Unknown","description":"The terms span both immune signaling (basophil activation, C-type lectin receptor signaling, NK cell chemotaxis) and kidney morphogenesis (metanephric tubule and limb development) with no shared process or interaction, and the cluster has no edges to connect them. This diversity provides no cohesive functional theme to label.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":1},{"id":"GO:0072237","count":1},{"id":"GO:0036303","count":1},{"id":"GO:0072287","count":1},{"id":"GO:0002223","count":1}]},{"hash":"712367247228490782","title":"GTPase-Driven Signaling and Synaptic Processes","description":"The cluster is enriched for GO terms centered on regulation of Rho and Ras GTPase signaling and general GTPase activity, suggesting a core theme of small GTPase\u2013mediated signal transduction. The presence of synaptic transmission and synaptic vesicle priming terms indicates involvement in neuronal communication, while other terms (acrosome reaction, thrombin receptor signaling, neutrophil degranulation regulation) reflect broader signaling pathways that share components with GTPase-regulated processes. Overall, the dominant pattern ties small GTPase signaling to synaptic regulation, with some ancillary signals, supporting this label.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0043314","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0043087","count":2},{"id":"GO:0046580","count":2}]},{"hash":"1649181050276784172","title":"Cartilage development and ECM remodeling","description":"Top GO terms converge on cartilage/bone morphogenesis and extracellular matrix remodeling, including endochondral ossification, collagen fibril organization/catabolic processes, and integrin biosynthetic activity, with a few peripheral terms like podocyte development and lipoprotein clearance.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0001958","count":2}]},{"hash":"1796739861362662099","title":"Steroid Biosynthesis and Metabolism","description":"This cluster shows strong representation of steroid biosynthetic processes (cortisol, testosterone, aldosterone, progesterone) and related homeostasis (brassinosteroids), suggesting a shared theme of steroid production and regulation. The other terms reflect broader biosynthetic and metabolic contexts (vancomycin and insecticide metabolism) and hormonal effects like uterus development, which can be linked to steroid signaling. Overall, the dominant pattern is steroid biosynthesis and metabolism.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033072","count":8},{"id":"GO:0034651","count":8},{"id":"GO:0061370","count":8},{"id":"GO:0032342","count":8},{"id":"GO:0017143","count":8}]},{"hash":"984998490509791343","title":"Membrane Signaling and Ion Transport","description":"The top GO terms cluster around membrane-associated signaling and transport: potassium and sodium ion transport; GPCR desensitization; receptor clustering and general signal transduction. Additional terms for angiogenesis and axonogenesis reflect growth signaling, and the lipopolysaccharide response points to immune signaling. Together, they suggest a unifying theme of cellular communication via membrane signaling and ion flux rather than a single specific function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006813","count":6},{"id":"GO:0001525","count":4},{"id":"GO:0071222","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0043113","count":4}]},{"hash":"1708893654449205662","title":"Fungal Recognition and Innate Immune Signaling","description":"The top GO terms point to innate immune responses to fungal origin, notably cellular response to fungal molecules, C-type lectin receptor signaling, and basophil activation, suggesting a fungal-recognition and immune-signaling theme. Some kidney development terms appear, likely annotation noise, so the core theme remains immune-related.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0002223","count":4},{"id":"GO:0045575","count":3},{"id":"GO:0072237","count":3}]},{"hash":"808382814862789675","title":"Metanephric kidney development","description":"The top GO terms are dominated by metanephric morphogenesis (proximal/distal tubule development and ascending limb development), indicating a shared role in nephron formation; other immune-related terms appear less consistently, so the kidney development theme is the strongest signal. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":4},{"id":"GO:0072237","count":4},{"id":"GO:0036303","count":4},{"id":"GO:0072287","count":4},{"id":"GO:0002223","count":4}]},{"hash":"1229732292343540835","title":"Ubiquitin-Proteasome Regulation of the Cell Cycle","description":"The cluster's top GO terms converge on ubiquitin-dependent protein catabolic processes and SCF-mediated proteolysis, plus spindle assembly and microtubule dynamics, all of which tie to cell-cycle control and mitotic/meiosis-related processes. While some developmental terms appear, the dominant signal is ubiquitin-proteasome\u2013driven regulation of cell division machinery.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0070544","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0007057","count":4},{"id":"GO:0021993","count":4}]},{"hash":"253776573357558110","title":"ECM Remodeling and Morphogenesis","description":"Top GO terms cluster around extracellular matrix remodeling and tissue development, such as collagen catabolic processes, basement membrane disassembly, bone resorption, and intramembranous ossification, alongside branching morphogenesis in the lung and uterine decidualization. While a couple of terms are more peripheral (e.g., T cell cytotoxicity, neuropeptide catabolic process), the dominant signal is remodeling of the ECM during organ development and tissue morphogenesis.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":7},{"id":"GO:0045453","count":7},{"id":"GO:0051603","count":7},{"id":"GO:0001913","count":7},{"id":"GO:0030574","count":7}]},{"hash":"102664802557957635","title":"Plant cell wall remodeling and plasmodesmata organization","description":"The terms are dominated by plant-type cell wall modification, regulation of cellulose biosynthetic process, and plasmodesma organization, indicating proteins involved in plant cell wall remodeling and intercellular transport. Some unrelated terms appear, but the core signal is clearly plant cell wall dynamics.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":4},{"id":"GO:2001009","count":4},{"id":"GO:0009663","count":4},{"id":"GO:0006486","count":2},{"id":"GO:0075015","count":2}]},{"hash":"896013987417954609","title":"Skeletal ECM remodeling","description":"The GO terms are dominated by collagen organization and turnover (collagen fibril organization, collagen catabolic process), cartilage development, and endochondral ossification, plus integrin biosynthetic processes, all pointing to extracellular matrix assembly/remodeling during skeletal development (cartilage and bone formation). Some outliers exist, but the core signal supports a label focused on skeletal ECM remodeling.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0033034","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0001958","count":2}]},{"hash":"1646707349792126223","title":"Olfactory perception and odor detection","description":"GO terms point to olfactory behavior and chemical stimulus detection, suggesting the proteins are involved in smell sensing.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042048","count":2},{"id":"GO:0050907","count":2}]},{"hash":"600966857713186944","title":"Unknown","description":"Cannot determine a common biological theme because no GO terms are shown for this cluster; without top terms to guide naming, the proteins' shared function is unclear.","confidence":"","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[]},{"hash":"1007202060939291524","title":"Unknown","description":"The terms are highly diverse: antibiotic biosynthesis, angiogenesis, various acetylation processes, and chromatin-related functions, with no clear single pathway or molecular role uniting the cluster. This makes it hard to assign a specific, representative label beyond Unknown.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0019491","count":2},{"id":"GO:0030187","count":2},{"id":"GO:0006348","count":2}]},{"hash":"1058575717696430219","title":"RNAi-Related Gene Silencing and Translation Control","description":"This cluster is dominated by GO terms tied to RNA interference and gene silencing processes, including translational initiation, ta-siRNA processing, and co-transcriptional gene silencing by RNA interference machinery. While some terms are obsolete or touch on germline development, the core recurring theme across the terms points to RNA silencing pathways and regulation of translation, suggesting these proteins function together in RNAi-mediated regulation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006413","count":1},{"id":"GO:1905618","count":1},{"id":"GO:0010267","count":1},{"id":"GO:0030727","count":1},{"id":"GO:0010216","count":1}]},{"hash":"59800099221116262","title":"Starvation-Responsive Metabolism","description":"The cluster centers on metabolic processes related to lipid and energy metabolism (cholesterol, propionyl-CoA, ketone bodies, adipose development, L-isoleucine catabolism) and stress responses (oxidative stress, starvation) with links to transcriptional regulation, suggesting a cohesive function in metabolic adaptation during nutrient scarcity.","confidence":"Medium","size":7,"edges":7,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0034599","count":2},{"id":"GO:1902860","count":1}]},{"hash":"428693041778566650","title":"Actin-driven cytoskeleton remodeling and endocytosis","description":"These proteins cluster around actin cytoskeleton dynamics (e.g., positive regulation of Arp2/3-mediated actin nucleation; actin filament organization) and membrane-trafficking processes (plasma membrane tubulation, endocytosis/pinocytosis, vesicle trafficking). The presence of budding-site selection terms hints at yeast polarity contexts, which often hinge on actin organization. Overall, the core theme is actin-dependent cytoskeleton remodeling coupled to membrane remodeling and endocytic processes.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000601","count":3},{"id":"GO:0050731","count":3},{"id":"GO:0030476","count":2},{"id":"GO:0097320","count":2},{"id":"GO:0048488","count":2}]},{"hash":"887925401553808740","title":"Placental Development and miRNA-Mediated Gene Regulation","description":"The top GO terms strongly point to placenta development and embryo implantation, suggesting a core role in placental biology. In addition, multiple terms relate to regulation of gene expression via miRNA pathways and circadian control, indicating a dominant theme of post-transcriptional gene regulation within this cluster. Some inflammatory and oxidative stress responses are also present, which can accompany placental and immune regulation. Overall, the cluster appears to center on placental development with concomitant miRNA-mediated gene regulation. ","confidence":"Medium","size":7,"edges":13,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":4},{"id":"GO:0007566","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0060336","count":4},{"id":"GO:0032922","count":3}]},{"hash":"1870296119040803138","title":"Membrane-associated lipid metabolism","description":"The top GO terms cluster around membrane-related processes (GPI anchor attachment, rhabdomere membrane biogenesis) and lipid handling (lipid droplet organization, triglyceride catabolic process), suggesting a functional group of proteins involved in membrane protein maturation/localization and lipid metabolism. Some gravity/visual learning terms seem incidental, but the core theme is membrane-associated lipid processes.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016255","count":2},{"id":"GO:0045313","count":2},{"id":"GO:0090141","count":1},{"id":"GO:0009590","count":1},{"id":"GO:0009959","count":1}]},{"hash":"87978712853667160","title":"Synaptic regulation and APP metabolism","description":"The top GO terms cluster around neuronal synapses: vesicle clustering, receptor internalization, regulation of postsynaptic potentials, and learning. The amyloid precursor protein metabolic process ties into neuronal synaptic regulation via APP processing. Some terms like retina development and iodide transport suggest broader tissue expression but do not override the central synaptic theme.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090394","count":4},{"id":"GO:1902474","count":3},{"id":"GO:0042982","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0015705","count":3}]},{"hash":"63295032707362694","title":"Embryogenesis: Mesoderm and Placental Development","description":"Based on the top GO terms, the cluster is strongly enriched for multicellular organism development, mesoderm development, trophoblast giant cell differentiation, and placenta/endocrine development terms. This points to a cohesive theme around early embryogenesis with emphasis on mesodermal lineage and placental formation, with a few assorted endocrine-related terms that still fit within organogenesis. Confidence is High.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0010957","count":1},{"id":"GO:0003323","count":1}]},{"hash":"1211197409346335301","title":"RNA processing and translation regulation","description":"Most of the top GO terms relate to mRNA metabolism (export, modification, splicing, stability) and to translation control (reinitiation, IRES-dependent initiation). This suggests a cluster of proteins involved in processing RNA and regulating translation, with a core emphasis on RNA metabolism and protein synthesis. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":5},{"id":"GO:1902625","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0001825","count":4},{"id":"GO:0010610","count":4}]},{"hash":"1371906970837640050","title":"Nucleobase Transporters","description":"The top GO terms are all about transport of nucleobases and related compounds (adenine, guanine, hypoxanthine, xanthine, urate, uracil) across the plasma membrane, indicating a cluster of nucleobase/purine transport proteins. A couple of sensory perception terms appear but are likely incidental noise relative to the core transporter function. Overall, the cluster is best described as nucleobase transporters.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098702","count":1},{"id":"GO:1903825","count":1},{"id":"GO:0035344","count":1},{"id":"GO:0070904","count":1},{"id":"GO:0098710","count":1}]},{"hash":"333845973455035168","title":"Unknown","description":"The GO terms span brain development, adipose tissue development, innate immune response, cell division, and a variety of metabolic pathways, with no single unifying biological process connecting them all. This broad and dispersed set makes it hard to assign a cohesive functional label to the cluster. ","confidence":"","size":7,"edges":12,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0019516","count":2},{"id":"GO:1902860","count":2}]},{"hash":"1881197566094850929","title":"Embryonic Development and Neuronal Axon Guidance","description":"GO terms show broad developmental themes across multiple tissues (heart, placenta, forebrain, inner ear, skeletal muscle, vagina) and explicit neural connectivity events (retinal ganglion cell axon guidance, CNS projection neuron axonogenesis, motor neuron axon guidance), suggesting a general embryonic development program with emphasis on neural patterning and axon guidance rather than a single tissue function.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0001890","count":4},{"id":"GO:0031290","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0060068","count":4}]},{"hash":"1408890230278775122","title":"Amino acid metabolism and growth hormone signaling","description":"The cluster includes GO terms related to amino acid metabolism (L-arginine biosynthetic process, L-glutamine metabolic process, response to amino acid, starvation) and hormonal/growth-related processes (response to glucagon stimulus, response to growth hormone, hepatocyte differentiation, brainstem development, organ regeneration). This suggests a theme of metabolic regulation intertwined with growth and developmental processes, hence the label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":2},{"id":"GO:0006541","count":1},{"id":"GO:0071377","count":1},{"id":"GO:0031100","count":1},{"id":"GO:0043200","count":1}]},{"hash":"946170031411560686","title":"Nucleocytoplasmic Transport and SRP Targeting","description":"The cluster shows GO terms for SRP-dependent cotranslational targeting to membranes (ER targeting) alongside nuclear transport processes (nuclear pore organization, NLS-based import into the nucleus, mRNA export). This points to a cohesive theme of proteins involved in directing translation products to membranes and mediating nucleus-cytoplasm transport, justifying a combined label of nucleocytoplasmic transport and SRP targeting.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006614","count":1},{"id":"GO:0006616","count":1},{"id":"GO:0006617","count":1},{"id":"GO:0072417","count":1},{"id":"GO:0006999","count":1}]},{"hash":"2186169495060357428","title":"Neural Axon Guidance and Vascular Morphogenesis","description":"The cluster centers on neural development features (axon extension, axonogenesis, sensory neuron axon guidance, and synapse assembly) and vascular morphogenesis (retina and coronary artery morphogenesis) with supporting roles for HGF signaling and endosomal localization, suggesting coordinated neural wiring and blood vessel formation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048846","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0010751","count":2},{"id":"GO:2001027","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1255943872852405288","title":"MAPK-driven inflammatory stress signaling and angiogenesis","description":"This cluster centers on stimuli-induced stress and inflammatory responses (LPS, PMA, virus, arsenite, ionomycin) and the activation/regulation of MAPK cascades (JNK and p38), with an apparent connection to angiogenesis, suggesting a cohesive role in MAPK-mediated stress signaling that can promote vascular growth.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:1904628","count":2},{"id":"GO:0098586","count":2},{"id":"GO:1903936","count":2},{"id":"GO:0045766","count":2}]},{"hash":"1921263740411734886","title":"Inflammatory signaling and cytoskeletal remodeling","description":"Top GO terms point to multiple signaling and immune-related pathways (JNK cascade, LPS response, STAT tyrosine phosphorylation, TRK signaling) and to cytoskeletal dynamics (receptor clustering, actin filament binding) as well as growth/angiogenesis. Although there is some diversity, the common theme is proteins involved in transducing signals and coordinating cytoskeleton rearrangements during inflammatory or growth-related responses.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032436","count":4},{"id":"GO:0007254","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0042517","count":3}]},{"hash":"888957045665150648","title":"Embryogenesis and thyroid hormone signaling","description":"This cluster prominently features in utero embryonic development and thyroid hormone receptor signaling, including regulation of that pathway, which suggests a core theme around developmental processes modulated by thyroid signaling. Additional terms reflect related developmental and immune-regulatory activities, but the thyroid- and embryogenesis-related terms are most representative of the cluster's function.","confidence":"Medium","size":7,"edges":10,"triangles":6,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":7},{"id":"GO:0071222","count":6},{"id":"GO:0035264","count":6},{"id":"GO:2001275","count":6},{"id":"GO:0090340","count":6}]},{"hash":"1307804172424300153","title":"Cell Cycle and DNA Replication","description":"Most terms point to core cell division and DNA synthesis: meiotic cell cycle, G1/S transition, kinetochore localization, and DNA replication. These indicate the cluster centers on the machinery of cell division. The neural development and signaling terms (Schwann cell development, excitatory postsynaptic potential, cocaine response) and angiogenesis appear as secondary associations, likely reflecting dual roles of some proteins in neural tissues or broader signaling pathways. Overall, the dominant theme is cell cycle and replication.","confidence":"High","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051321","count":7},{"id":"GO:0000082","count":7},{"id":"GO:0034501","count":7},{"id":"GO:0006260","count":7},{"id":"GO:0014044","count":7}]},{"hash":"1913819950367767510","title":"Neuronal development and microtubule dynamics","description":"The terms cluster around neural development (neuron differentiation, migration) and cytoskeletal/microtubule processes (nucleation, cytoplasmic organization, spindle midzone assembly), plus translation regulation. This pattern suggests a coherent theme where proteins coordinate neuronal differentiation with microtubule remodeling and cell division, reflecting roles in neural morphogenesis and cytoskeletal dynamics.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030182","count":5},{"id":"GO:1902408","count":4},{"id":"GO:1905789","count":4},{"id":"GO:2000767","count":4},{"id":"GO:0051256","count":4}]},{"hash":"480164866744027944","title":"Hepatic development and metabolism","description":"This cluster centers on liver-associated functions: liver development, gluconeogenesis, and xenobiotic response, along with cell cycle and secretory/process maintenance features that align with hepatocyte biology and liver metabolism. The combination of development, metabolism, and detox-related GO terms strongly points to liver-specific processes, making this a cohesive hepatic cluster.","confidence":"High","size":7,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0019878","count":2}]},{"hash":"1017665954398120093","title":"Axonogenesis and neurotrophin signaling","description":"The cluster centers on neuronal development and signaling, with terms for axonogenesis, neurotrophin TRK receptor signaling, receptor clustering, and actin cytoskeleton regulation, all pointing to neurite outgrowth and receptor-mediated signaling in neurons. Peripheral terms like angiogenesis and inflammatory response appear less central, but do not override the main neuronal theme.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0042517","count":1},{"id":"GO:2001275","count":1},{"id":"GO:0043113","count":1}]},{"hash":"2000877810824090898","title":"Chromatin assembly and histone modification","description":"The top terms cluster around nucleosome assembly, chromatin organization (including heterochromatin) and histone methylation marks (H3-K4 and H3-K27), indicating proteins involved in chromatin structure and histone state regulation. This thematic coherence supports labeling the cluster as chromatin assembly and histone modification.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":2},{"id":"GO:0080182","count":1},{"id":"GO:0006334","count":1},{"id":"GO:0016584","count":1},{"id":"GO:0097298","count":1}]},{"hash":"1109660320585560953","title":"Calcium-dependent neuronal signaling and synaptic plasticity","description":"This cluster shows a coherent theme around neuronal signaling and calcium/cAMP dynamics, highlighted by GO terms for release of sequestered calcium, regulation of calcium release, cellular responses to cAMP, and long-term synaptic depression, suggesting roles in activity-dependent synaptic modulation. Some terms like epithelial polarity or sodium transport may reflect peripheral functions or broader protein roles, but the core theme is calcium-mediated neural signaling.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0007603","count":2},{"id":"GO:0090162","count":2}]},{"hash":"1834393445594222141","title":"Neurotrophin signaling and axonogenesis","description":"This cluster centers on neurotrophin TRK receptor signaling (GO:0042517) and axonogenesis (GO:0007409), with receptor clustering (GO:0043113) and actin filament binding (GO:1904531) linking to neurite outgrowth and cytoskeletal remodeling. While there are peripheral terms like angiogenesis and LPS response, the dominant pattern points to neuronal development and signaling pathways driving axon growth.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0042517","count":1},{"id":"GO:2001275","count":1},{"id":"GO:0043113","count":1}]},{"hash":"1239340570676855380","title":"Steroid and Fatty Acid Metabolism with Transcription Regulation","description":"The GO terms point to lipid metabolism (fatty acid elongation and very long-chain fatty acid biosynthesis) and steroid-related pathways (testosterone biosynthesis and steroid catabolic process), along with retinoic acid and phylloquinone processes, plus regulation of transcription. This suggests a functional cluster centered on lipid/steroid metabolism with some transcriptional control, though there are some diverse/auxiliary terms like antibiotic response. Confidence: Medium.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0031427","count":2},{"id":"GO:0042761","count":2},{"id":"GO:0030497","count":2},{"id":"GO:0042376","count":2}]},{"hash":"233761979595411466","title":"Central Metabolism and Biosynthesis","description":"The top GO terms are dominated by core metabolic and biosynthetic processes (TCA cycle, glycolysis, thiamine biosynthesis, leucine catabolism, arginine biosynthesis, tRNA methylation), suggesting the proteins act mainly in energy production and amino acid metabolism. While there are also development and apoptotic terms, their lower representation makes them less central to the cluster\u2019s theme. Therefore, this label reflects the primary functional theme of the group.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0006526","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0007494","count":2}]},{"hash":"312200616808079560","title":"Sulfur Amino Acid Metabolism","description":"The cluster is dominated by GO terms for L-homocysteine catabolic process, transsulfuration, and L-cysteine biosynthetic processes, indicating a cohesive role in sulfur-containing amino acid metabolism; other terms like coenzyme M biosynthesis and cyanide metabolism are present but secondary. This supports a core function around cysteine/homocysteine turnover and related pathways.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043418","count":3},{"id":"GO:0018871","count":3},{"id":"GO:0019343","count":3},{"id":"GO:0019295","count":3},{"id":"GO:0046360","count":3}]},{"hash":"1741189505975056099","title":"Protein homeostasis and organelle trafficking","description":"The GO terms point to proteostasis and turnover (protein processing, chaperone-mediated assembly, oxidation-dependent protein catabolic processes, stress granule disassembly) together with organelle-associated trafficking and assembly (mitochondrial Complex III assembly, intralumenal vesicle formation, SNARE disassembly, peroxisome matrix import receptor recycling). While diverse, they converge on protein quality control across compartments and vesicle-mediated transport pathways.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016485","count":2},{"id":"GO:0034551","count":1},{"id":"GO:0070676","count":1},{"id":"GO:0035494","count":1},{"id":"GO:0016562","count":1}]},{"hash":"1535327915996054272","title":"Steroid Hormone Biosynthesis & Metabolism","description":"The top GO terms are dominated by biosynthetic processes for cortisol, testosterone, aldosterone, and progesterone, with related terms like brassinosteroid homeostasis, indicating a shared theme around steroid synthesis and metabolic regulation. Although there are some miscellaneous terms (e.g., vancomycin biosynthesis, insecticide metabolism), the core pattern points to steroid hormone production and related metabolism.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033072","count":4},{"id":"GO:0034651","count":4},{"id":"GO:0061370","count":4},{"id":"GO:0032342","count":4},{"id":"GO:0017143","count":4}]},{"hash":"1416780406200879551","title":"Ubiquitination-driven chromatin regulation and protein QC","description":"This cluster overrepresents ubiquitination-related processes (K63-linked ubiquitination, neddylation, histone ubiquitination) and proteasome-mediated quality control, with supporting signals in chromatin dynamics (heterochromatin formation). A cohesive theme is ubiquitin-mediated regulation of protein fate and chromatin state, with some related cell-cycle components, making this an apt label.","confidence":"High","size":7,"edges":14,"triangles":12,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043951","count":6},{"id":"GO:0070534","count":6},{"id":"GO:0006348","count":6},{"id":"GO:0009737","count":6},{"id":"GO:0045116","count":6}]},{"hash":"810839646456691980","title":"Cartilage and Bone ECM Remodeling","description":"The top GO terms cluster around cartilage development, endochondral ossification, collagen fibril organization, and integrin biosynthesis\u2014points to extracellular matrix (ECM) assembly and skeletal tissue formation. While a few terms are more peripheral (e.g., podocyte development, lipoprotein clearance), the dominant signal is ECM-related processes linked to cartilage and bone formation, hence the chosen label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":1},{"id":"GO:0033034","count":1},{"id":"GO:0060351","count":1},{"id":"GO:0045112","count":1},{"id":"GO:0001958","count":1}]},{"hash":"743010440018503469","title":"Cartilage and ECM Organization","description":"The top GO terms are dominated by collagen fibril organization, collagen catabolic process, cartilage development in endochondral ossification, endochondral ossification itself, and integrin biosynthetic process, all pointing to extracellular matrix assembly/remodeling and cartilage/bone formation. While some terms (e.g., lipoprotein clearance, podocyte development regulation) are peripheral, the central theme is ECM organization and cartilage/bone development, which justifies a cohesive label for this cluster.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":1},{"id":"GO:0033034","count":1},{"id":"GO:0060351","count":1},{"id":"GO:0045112","count":1},{"id":"GO:0001958","count":1}]},{"hash":"523477717926546679","title":"Neuronal signaling and sensory processing","description":"This cluster shows a clear emphasis on neurotransmission and sensory functions, with GO terms for serotonin receptor signaling, dopamine secretion, histamine response, and various sensory processes, including micturition-related transmission and cochlear development. Ion transport terms (sodium and chloride) further support neuronal excitability, suggesting a cohesive neural signaling/sensory role among the proteins.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0043200","count":4},{"id":"GO:0050893","count":4},{"id":"GO:2001226","count":4}]},{"hash":"2099486747426550858","title":"Unknown","description":"With no GO terms or shared functional annotations and no edges or connectivity among the proteins, there is no clear common function to define this cluster; the note about ReCIPE re-adding 20 proteins does not establish a coherent theme for these seven proteins.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"960530187711989993","title":"DNA replication and cell cycle machinery","description":"Based on the top GO terms, there is a strong emphasis on DNA replication, DNA-templated transcription, and cell division, with support from centriole elongation and microtubule severing, all pointing to mitotic and cytoskeletal regulation. Additional terms related to chaperone-mediated protein complex assembly, stress granule disassembly, and ER-Golgi transport suggest broader cellular quality control and trafficking processes that accompany cell cycle progression. Overall, the cluster appears to group proteins involved in DNA replication and the machinery governing cell division and cytoskeletal dynamics.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0006351","count":5},{"id":"GO:1903715","count":4},{"id":"GO:0035617","count":4}]},{"hash":"1254318546421122646","title":"Ubiquitin-Proteasome Degradation and ERAD","description":"The cluster\u2019s top GO terms are centered on ubiquitination and proteasome-mediated protein breakdown (SCF-dependent proteasomal ubiquitin-dependent catabolic process, ubiquitin-dependent ERAD pathway, protein polyubiquitination, and ubiquitin-dependent protein catabolic process), indicating a functional theme around protein quality control and degradation. Some developmental and glycoprotein turnover terms appear, but the dominant signal is ubiquitin-proteasome/ERAD\u2013driven proteolysis.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0043588","count":3}]},{"hash":"1404222860610518206","title":"Meiosis I spindle assembly and oocyte maturation","description":"This cluster is strongestly associated with spindle assembly in female meiosis I (GO:0007057), oocyte maturation (GO:0001556), and microtubule polymerization (GO:0046785), pointing to a cohesive theme of meiotic spindle dynamics and oocyte developmental processes. Additional terms about ubiquitin-proteasome degradation and cell cycle regulation support a broader context of meiosis control, though some neural development terms appear as secondary associations. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":6},{"id":"GO:0006516","count":5},{"id":"GO:0046785","count":5},{"id":"GO:0021678","count":5},{"id":"GO:0021993","count":5}]},{"hash":"1738185657697554676","title":"Meiosis I spindle assembly and oocyte maturation","description":"The terms cluster around meiotic spindle formation in female meiosis I, oocyte maturation, and related ubiquitin-proteasome\u2013mediated protein turnover involved in cell-cycle regulation. This combination strongly suggests a theme of meiosis and spindle dynamics in oocytes, with supporting links to cell-cycle control mechanisms, rather than broader, unrelated processes.  ","confidence":"High","size":7,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0021678","count":2},{"id":"GO:0021993","count":2},{"id":"GO:0070544","count":2}]},{"hash":"1738152701179436166","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0046784","count":1},{"id":"GO:0002188","count":1}]},{"hash":"1780616727703548084","title":"Unknown","description":"The listed GO terms span diverse processes from cell cycle regulation to mitochondrial functions, lipid biosynthesis, cell wall and infection structure formation, and protein localization, with no single cohesive biological theme dominating. This lack of a shared function makes a confident, specific label untenable.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000134","count":1},{"id":"GO:1903740","count":1},{"id":"GO:0070940","count":1},{"id":"GO:0046902","count":1},{"id":"GO:0010867","count":1}]},{"hash":"983799430097190936","title":"Neuronal development and synaptic signaling","description":"The proteins cluster around forebrain development and synaptic regulation (long-term synaptic depression, membrane hyperpolarization) with cytoskeletal and signaling links (actin capping, GTPase activity, TGF-beta response), suggesting a theme of neuronal growth and synaptic regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0030900","count":2}]},{"hash":"2283976076514810305","title":"Plant cell wall biosynthesis and plasmodesmata organization","description":"Dominant signals are plant-type cell wall processes: modification, cellulose biosynthesis regulation, plasmodesma organization, and general cell wall organization, plus root hair development and rhamnogalacturonan II biosynthesis. Some non-plant terms appear (lymph vessel development, epithelial adhesion), likely noise, but the core cluster clearly reflects plant cell wall biology.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":2},{"id":"GO:2001009","count":2},{"id":"GO:0009663","count":2},{"id":"GO:0071555","count":1},{"id":"GO:0010306","count":1}]},{"hash":"1042055281163239577","title":"Muscle sarcomere and cytoskeleton organization","description":"Top terms are dominated by muscle and cytoskeleton functions (sarcomere organization, skeletal muscle fiber development, Arp2/3-mediated actin nucleation, cell shape/polarity). While some terms are obsolete or unrelated, the recurring theme is actin cytoskeleton dynamics and muscle cell architecture, justifying a label for a cluster of proteins involved in muscle structure and cytoskeletal organization.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032508","count":4},{"id":"GO:0048741","count":3},{"id":"GO:0043486","count":3},{"id":"GO:0034314","count":3},{"id":"GO:0030476","count":3}]},{"hash":"1726838363649201993","title":"Diverse Solute Membrane Transporters","description":"These terms cluster around transmembrane transport of a wide range of substrates (nitrate, sodium, vitamins, sugars, xenobiotics, and related osmotic stress responses), indicating a group of proteins that function primarily as membrane transporters for diverse solutes.","confidence":"High","size":6,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0097080","count":2}]},{"hash":"2143069469228088721","title":"Unknown","description":"No functional terms are provided to identify a shared theme among the six proteins; the NP accession IDs alone do not reveal a common pathway, so a reliable label cannot be determined.","confidence":"","size":6,"edges":11,"triangles":6,"max_degree":4,"top_function":null,"top_go_terms":[]},{"hash":"505911361083125885","title":"SNARE-driven neuronal vesicle exocytosis and receptor trafficking","description":"This cluster centers on synaptic vesicle release and trafficking: SNARE complex assembly, regulation of vesicle priming, spontaneous neurotransmitter secretion, and exocytic insertion of receptors at the postsynaptic membrane, pointing to presynaptic exocytosis and postsynaptic receptor trafficking. Golgi organization/disassembly terms further support a secretory pathway connection; a single lipid metabolism term is likely less central to the core theme.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0061669","count":3},{"id":"GO:2000010","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0035493","count":3},{"id":"GO:0090166","count":3}]},{"hash":"1859024567101317457","title":"RNA processing and mRNA metabolism","description":"These proteins cluster around RNA handling: spliceosome-mediated mRNA splicing, regulation of mRNA stability, mitochondrial mRNA polyadenylation, and related mRNA binding processes. While a couple of terms touch on viral interactions or neural development, the core signals point to RNA maturation and turnover, supporting a label focused on RNA processing and metabolism.","confidence":"Medium","size":6,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0045716","count":2},{"id":"GO:0010323","count":2},{"id":"GO:0022013","count":2},{"id":"GO:0010610","count":2}]},{"hash":"2249946382241422101","title":"Unknown","description":"There is no functional signal: no top GO terms, no edges, and no triangles to guide a label, so a coherent common function cannot be inferred from the cluster.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"610652837533235181","title":"RNA processing and translation regulation","description":"This cluster centers on mRNA lifecycle processes: stability regulation in stress, spliceosome-mediated splicing (including alternative splicing), mRNA export, mRNA modification, and translation/reinitiation, indicating coordinated post-transcriptional control of gene expression.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0048025","count":2},{"id":"GO:0006412","count":2},{"id":"GO:1902625","count":1},{"id":"GO:0002188","count":1}]},{"hash":"1302878247194275407","title":"Neurite Development and Neuronal Polarity","description":"The top GO terms point to neural development (dendrite development) and cell polarity (epithelial apical/basal polarity, planar cell polarity), as well as receptor clustering, suggesting a shared role in neurite outgrowth, dendritic patterning, and synaptic/membrane organization. Some terms like immune signaling or hearing are likely less directly related noise, but the core theme is neural development and polarity. Edges are zero, but the label reflects a functional theme rather than a physical complex.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070433","count":5},{"id":"GO:0007605","count":5},{"id":"GO:0090179","count":4},{"id":"GO:0035750","count":4},{"id":"GO:0045198","count":4}]},{"hash":"891421003743346156","title":"Facial Morphogenesis","description":"The only strong annotation is GO:0060325 for face morphogenesis, suggesting these proteins may participate in shaping facial structures during development. Given the single term and minimal connectivity, the label is plausible but not strongly supported.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1}]},{"hash":"1217363553516525333","title":"Signaling and differentiation regulators","description":"The proteins show enrichment in signaling-related GO terms (NF-kappaB regulation, ERK cascade, peptidyl-serine phosphorylation, ubiquitination) and differentiation/growth processes (macrophage differentiation, osteoblast differentiation, multicellular organism growth), plus supporting roles in transcription and cytoskeletal dynamics (RNA polymerase II transcription, stress fiber assembly). This pattern points to a group involved in coordinating signaling pathways with developmental and cellular differentiation, rather than a single, narrow function.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043149","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0050975","count":2},{"id":"GO:0030225","count":2},{"id":"GO:0016567","count":2}]},{"hash":"1443016788414644344","title":"Skin Pigmentation and Kinase Signaling","description":"This cluster centers on regulation of phosphorylation events (autophosphorylation, tyrosine, and serine/threonine kinase activity) and signaling modulation (GTPase activity), along with supporting processes like actin remodeling and vesicle trafficking (ARP2/3, COPII). The explicit skin-related terms (pigmentation, skin development) together with multicellular development and hypoxia response suggest a theme of signaling networks governing epidermal maturation and pigment cell function, with accompanying cytoskeletal and trafficking dynamics. While the terms cover multiple related processes, they converge on signaling and cellular organization relevant to skin biology, justifying a cohesive skin-focused signaling label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031954","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0043588","count":2}]},{"hash":"1406366082551942443","title":"Cardiac development and heart morphogenesis","description":"Several dominant GO terms point to heart formation and structure formation: atrioventricular canal development, outflow tract and pulmonary valve morphogenesis, pericardium development, and paraxial mesoderm involvement\u2014all core to cardiac morphogenesis. Additional terms like nodal signaling and TGF-beta2 production relate to left-right patterning and signaling in heart development. Despite some older/obsolete labels, the shared theme across the terms indicates a cardiac development cluster.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036302","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0048264","count":1},{"id":"GO:1900224","count":1},{"id":"GO:0003184","count":1}]},{"hash":"2303955217518823433","title":"Neurodevelopment and Axon Regeneration","description":"Based on the top GO terms, the cluster shows signals related to brain development (telencephalon development) and regulation of axon regeneration, with receptor clustering relevant to synaptic organization. Although there are also terms tied to stress responses (lipopolysaccharide, cadmium), the neural development/axon dynamics theme is the strongest across the terms. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0090169","count":2},{"id":"GO:0048679","count":2},{"id":"GO:0021537","count":2}]},{"hash":"752135639588781915","title":"Embryonic and Tissue Development","description":"The listed GO terms span several developmental processes across different tissues (roof of the mouth/palate, pancreas, endocrine system, placenta/trophoblast, hair follicles, vulval fate, mesoderm), suggesting a general theme of development and differentiation rather than a single pathway. The inclusion of a transcriptional regulation term (RNA Pol II regulatory region DNA binding) aligns with broad developmental gene regulation. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":2},{"id":"GO:0010957","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0035270","count":1},{"id":"GO:1903026","count":1}]},{"hash":"263748131406728672","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0006413","count":2},{"id":"GO:0006415","count":2}]},{"hash":"111509971107764714","title":"Neural development and synaptic signaling","description":"Most top terms describe neural and retinal development and signaling (forebrain migration, retina morphogenesis, trans-synaptic signaling, and paranode axon localization). A couple of terms are broader developmental processes (notochord development, salivary gland boundary), and iron homeostasis is obsolete; nonetheless the dominant theme is neural development and synaptic signaling.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0007432","count":3},{"id":"GO:0042517","count":3},{"id":"GO:0021885","count":3},{"id":"GO:0002175","count":3}]},{"hash":"1411470776578052382","title":"Neuronal signaling and sensory processing","description":"This cluster centers on neuronal signaling and sensory pathways, with GO terms such as serotonin receptor signaling, dopamine secretion, synaptic transmission, and sensory processing, plus related behaviors and developmental terms (cochlea development, conditioned taste aversion). The common theme is neurotransmission and neural processing of sensory information.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0043200","count":1},{"id":"GO:0050893","count":1},{"id":"GO:0007628","count":1}]},{"hash":"216219376499856796","title":"Diverse Transmembrane Transport of Substrates","description":"Based on the top GO terms, the proteins are enriched for various transmembrane transport activities across the plasma membrane, covering ions, sugars, vitamins, and xenobiotics. The diversity of substrates points to a general membrane transport function rather than a single substrate, with some auxiliary association to osmotic stress responses.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0097080","count":2}]},{"hash":"1617712850389238600","title":"Ribosome Biogenesis and rRNA Modification","description":"The majority of terms point to ribosome biogenesis, preribosome and cytosolic ribosome assembly, rRNA maturation, and RNA base methylation, all related to protein synthesis; a couple terms are unrelated (neurotransmitter transport, insulin secretion), but the dominant theme is ribosome-related biology.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002127","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0070475","count":1}]},{"hash":"1883810222134359569","title":"Neuronal development and synaptic signaling","description":"The cluster is dominated by neuronal-related GO terms, such as excitatory postsynaptic potential, hippocampus development, axonogenesis regulation, and ephrin receptor signaling, suggesting a module focused on neural development and synaptic communication. Some cell-cycle terms appear as noise, which lowers the overall coherence of the theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0021766","count":3},{"id":"GO:0051321","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0000082","count":3}]},{"hash":"1442232164010947643","title":"Neural Development and Retinal Differentiation","description":"The terms are dominated by nervous-system development and sensory neuron differentiation, including dorsal spinal cord development, retinal bipolar neuron differentiation, ectoderm formation, pituitary gland development, and regulation of neuron apoptotic processes. This pattern suggests a cluster of proteins involved in neurodevelopment and retinal/sensory lineage differentiation rather than a single, narrow function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":4},{"id":"GO:0043524","count":4},{"id":"GO:0002087","count":4},{"id":"GO:0021983","count":3},{"id":"GO:0023019","count":2}]},{"hash":"1316160850808724833","title":"Ribosome biogenesis and translation","description":"Top terms are centered on translation and ribosomal large subunit biogenesis/assembly, pointing to a cluster of proteins involved in ribosome production and protein synthesis. Additional terms related to protein targeting and stabilization support a role in maintaining functional translation machinery. Therefore, the cluster is best described as ribosome biogenesis and translation machinery.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0046898","count":1},{"id":"GO:0032092","count":1},{"id":"GO:2000435","count":1}]},{"hash":"1124278103013858870","title":"Cross-tissue differentiation and morphogenesis","description":"Top GO terms span development and differentiation across diverse tissues (lung saccule, right ventricle, erythrocyte, mast cell, GABAergic neuron, nephron tubule, ureter) and include branching morphogenesis, indicating a general developmental/differentiation program rather than a single pathway. Peripheral terms like interferon response and histone methylation regulation do not define a unified function. Therefore the cluster is best described as cross-tissue differentiation and morphogenesis.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060430","count":2},{"id":"GO:0003215","count":2},{"id":"GO:0061085","count":2},{"id":"GO:0010724","count":2},{"id":"GO:0060374","count":2}]},{"hash":"655310526634125135","title":"Telomere maintenance and cell cycle signaling","description":"This cluster shows strong representation of telomere capping and telomere maintenance via telomerase, along with DNA replication and centrosome duplication, and also includes growth-related signaling like canonical Wnt and transcriptional regulation, suggesting a core theme of coordinated cell cycle progression and genome stability driven by growth signals.","confidence":"Medium","size":6,"edges":7,"triangles":2,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1904355","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0032212","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0051298","count":4}]},{"hash":"1273870365849444328","title":"Cellular maintenance and genome integrity","description":"This cluster centers on core housekeeping processes: protein quality control (aggrefy/negative regulation of proteasomal degradation), ER targeting of tail-anchored proteins, ribosome biogenesis (rRNA maturation), mitochondrial dynamics (fusion), and DNA repair (NER). These shared themes point to a broad maintenance-of-cellular homeostasis and genome integrity function, rather than a single specific pathway. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035973","count":3},{"id":"GO:0071816","count":3},{"id":"GO:0010216","count":3},{"id":"GO:1901799","count":3},{"id":"GO:0017085","count":3}]},{"hash":"1902151053583524220","title":"Unknown","description":"The top GO terms cover a wide range of developmental processes (gono\u00addal, brain, hindlimb, heart outflow tract) as well as immune signaling and transcription/chromatin regulation, with no single unifying function linking the proteins. Because the cluster lacks a cohesive common theme, a specific, representative label cannot be confidently assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":3},{"id":"GO:0035264","count":2},{"id":"GO:0002227","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0007420","count":2}]},{"hash":"90851505107129110","title":"ER Stress and COPII Trafficking","description":"This cluster is enriched for ER-related processes: COPII-coated vesicle budding, protein localization to the endoplasmic reticulum, unfolded protein response, and ER calcium homeostasis, pointing to ER quality control and trafficking between ER and Golgi as the shared function. Some viral interaction terms may reflect ER stress responses during infection, but the dominant theme is ER stress/trafficking.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":1},{"id":"GO:0006987","count":1},{"id":"GO:0044828","count":1},{"id":"GO:0006874","count":1},{"id":"GO:0044829","count":1}]},{"hash":"1516137865117731040","title":"Unknown","description":"The GO terms are highly heterogeneous, including retina development, nucleotide biosynthesis, immune signaling, and protein complex assembly, with no clear shared function; the small cluster size and lack of edges suggest a non-cohesive set rather than a single functional module.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":1},{"id":"GO:0006183","count":1},{"id":"GO:0006144","count":1},{"id":"GO:0071353","count":1},{"id":"GO:0046651","count":1}]},{"hash":"1954707603196706495","title":"Developmental cell migration and cytoskeletal remodeling","description":"This cluster is enriched for terms related to cell movement and shape change (cell migration, actin filament branching, cell polarity) and includes development-related processes (cochlea morphogenesis, synapse plasticity, VEGF response) as well as hemopoiesis, suggesting a broad developmental role centered on cytoskeletal dynamics and tissue morphogenesis. Although not all terms map to a single pathway, the common theme is cells migrating and remodeling their cytoskeleton during development.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030097","count":3},{"id":"GO:0016477","count":3},{"id":"GO:2001275","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0010765","count":2}]},{"hash":"610190266946732967","title":"Neuronal development and synapse organization","description":"Top terms cluster around neural development and synapse assembly (axon guidance, postsynaptic clustering, neuroligin clustering, receptor clustering), with only a few outliers (immune response, eye morphogenesis).","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097028","count":1},{"id":"GO:0045176","count":1},{"id":"GO:0048846","count":1},{"id":"GO:0043113","count":1},{"id":"GO:0045995","count":1}]},{"hash":"257919173318078854","title":"Vascular Tone and Blood Pressure Signaling","description":"This cluster centers on cardiovascular regulation, especially vasodilation and systemic arterial blood pressure, supported by diverse GPCR signaling pathways (dopamine and opioid receptor signaling, octopamine/tyramine signaling) and mediators like norepinephrine/epinephrine and angiotensin. While a few terms (electronic transport chain, neuronal migration, coagulation) are less directly tied, the dominant theme is signaling that modulates vascular tone and heart-related processes. Overall, the set most represents cardiovascular signaling and blood pressure control topics.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0031635","count":1},{"id":"GO:0008284","count":1},{"id":"GO:0002025","count":1},{"id":"GO:0022900","count":1}]},{"hash":"61554225167989665","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":1},{"id":"GO:0051259","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0032781","count":1}]},{"hash":"515363231312291095","title":"Unknown","description":"The GO terms span diverse processes with only a few related to sexual development (genital disc primordium determination, male sex determination, regulation of female gonad development); other terms reference growth signaling and general transcription or differentiation, with no clear shared function among the proteins. Thus no single cohesive function emerges to label the cluster.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035225","count":1},{"id":"GO:0070141","count":1},{"id":"GO:0048009","count":1},{"id":"GO:0060267","count":1},{"id":"GO:0045945","count":1}]},{"hash":"673628063997646160","title":"Unknown","description":"The cluster shows a scattered mix of GO terms spanning lipid metabolism (fatty acid elongation and very long-chain fatty acid biosynthesis), vitamin/steroid pathways (retinoic acid and phylloquinone catabolic processes, testosterone biosynthesis), and some immune/drug-response terms (natural killer cell cytotoxicity, response to methotrexate/antibiotics) with no single cohesive function tying all proteins together. Therefore there isn't a clear theme to assign a specific label beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042267","count":2},{"id":"GO:0031427","count":1},{"id":"GO:0042761","count":1},{"id":"GO:0030497","count":1},{"id":"GO:0042376","count":1}]},{"hash":"1636728175788756419","title":"Unknown","description":"Unknown. The top GO terms span transcription (DNA-templated transcription), several biosynthetic and catabolic processes (amino acids and lipids), and even Notch signaling, with multiple obsolete terms. This broad, heterogeneous mix provides no single cohesive function to define the cluster.","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0033585","count":2},{"id":"GO:0006533","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0000105","count":2}]},{"hash":"1668763817914601938","title":"Steroid and Fatty Acid Metabolism","description":"The top GO terms cluster around lipid-related processes: fatty acid elongation and very long-chain fatty acid biosynthesis, plus testosterone biosynthetic and steroid catabolic processes. This points to a shared function in lipid metabolism and steroid hormone pathways. Some terms (lung development, drug responses, transcription regulation) are less central and may reflect broader annotations or pleiotropy, but the dominant theme is lipid/steroid metabolism. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":3},{"id":"GO:0031427","count":2},{"id":"GO:0042761","count":2},{"id":"GO:0030497","count":2},{"id":"GO:0042376","count":2}]},{"hash":"1688065769179169285","title":"Unknown","description":"The top GO terms span diverse biosynthetic and regulatory processes (fatty acid elongation, very long-chain fatty acid biosynthesis, retinoic acid and testosterone biosynthesis, phylloquinone catabolism, methotrexate/antibiotic response, transcription regulation, lung development, poly-hydroxybutyrate biosynthesis) with no clear shared function or pathway. There are no edges or clusters linking these terms, suggesting the proteins do not represent a cohesive functional group. Therefore, no specific, representative label can be assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031427","count":1},{"id":"GO:0042761","count":1},{"id":"GO:0030497","count":1},{"id":"GO:0042376","count":1},{"id":"GO:0061370","count":1}]},{"hash":"1012273104454850363","title":"Embryonic development and tissue differentiation","description":"GO terms emphasize embryonic development and growth (in utero, neuron maturation, multicellular growth) plus tissue differentiation signals (thyroid signaling, prostate epithelial differentiation, lysosomal secretion) and regulatory pathways, suggesting a broad developmental/differentiation program.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":4},{"id":"GO:0042551","count":4},{"id":"GO:0071222","count":3},{"id":"GO:0035264","count":3},{"id":"GO:2001275","count":3}]},{"hash":"1861478910318362568","title":"N-glycan trimming and ERAD","description":"GO terms here center on glycoprotein processing, particularly trimming of N-glycan mannose residues in the ER/Golgi and pathways directing misfolded glycoproteins to the cytosol for ubiquitin-dependent degradation (ERAD), including retrograde transport. This points to a cohesive function: processing and quality control of N-glycoproteins via ERAD-related pathways. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":1},{"id":"GO:0097466","count":1},{"id":"GO:0036512","count":1},{"id":"GO:0036510","count":1},{"id":"GO:1904154","count":1}]},{"hash":"917917751742402033","title":"Unknown","description":"The GO terms cover a broad and disparate set of functions\u2014from metabolism and muscle structure to blood platelet aggregation, oxidative stress responses, and dopaminergic signaling\u2014without a single unifying biological theme. This makes it difficult to assign a specific, representative label to the cluster.","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0070527","count":2},{"id":"GO:0006979","count":1},{"id":"GO:1903181","count":1}]},{"hash":"472823207741737666","title":"Unknown","description":"The terms span nematode molting, pharyngeal pumping, multiple neuromodulatory signaling pathways (dopamine, octopamine/tyramine, opioid receptor-related), vascular regulation, neuron migration, cell proliferation, and energy metabolism, showing no coherent, single shared function for the cluster.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":1},{"id":"GO:0043050","count":1},{"id":"GO:0031635","count":1},{"id":"GO:0008284","count":1},{"id":"GO:0002025","count":1}]},{"hash":"442373753087958235","title":"Brain Development and Regeneration","description":"These proteins show strong associations with telencephalon development, angiogenesis, and axon regeneration, pointing to neural development and neural repair as the core theme. Additional terms related to immune/stress responses (lipopolysaccharide and cadmium exposure) suggest contextual regulation or injury-related signaling that can accompany neural processes. Overall, the label reflects the dominant neural development/regeneration theme with some ancillary stress-response signals.","confidence":"Medium","size":6,"edges":8,"triangles":3,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":6},{"id":"GO:0071222","count":6},{"id":"GO:0090169","count":6},{"id":"GO:0048679","count":6},{"id":"GO:0021537","count":6}]},{"hash":"1151913124123813866","title":"Unknown","description":"The top GO terms span mitochondrial distribution/inheritance, ribosome biogenesis and tRNA modification, intracellular trafficking (endosome-to-Golgi), cell division, along with neuronal GABAergic signaling and other diverse cellular processes. This broad mix suggests no single cohesive function or pathway defines the cluster, indicating a heterogeneous set of proteins rather than a unified theme.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048312","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0051932","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006400","count":2}]},{"hash":"652997403149661229","title":"Neurotransmitter signaling and sensory processing","description":"The Top Terms include serotonin receptor signaling, dopamine secretion, histamine response, cochlea development, sensory processing, taste aversion, and micturition-related transmission. This pattern points to neural signaling pathways that regulate sensory perception and related behaviors (hearing, taste, movement, and urinary reflexes). Thus, the cluster likely groups proteins involved in neurotransmitter signaling within sensory/behavioral contexts.","confidence":"High","size":6,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":3},{"id":"GO:0043200","count":3},{"id":"GO:0050893","count":3},{"id":"GO:0007628","count":3},{"id":"GO:2001226","count":3}]},{"hash":"1329903195015151195","title":"Unknown","description":"No shared GO terms or functional signal are present for this cluster. With only 1 edge, no triangles, and no top terms to guide labeling, there is no clear common function across the proteins. Therefore, the appropriate label is Unknown.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"572073172475242167","title":"Neural development and ER stress signaling","description":"The top GO terms cluster around neural development (forebrain development, multicellular organism development, neural tube closure) and growth control (Hippo signaling, negative regulation of cardiac muscle cell proliferation), with supporting transcription-related terms. The presence of an intrinsic apoptotic signaling pathway in response to ER stress adds a stress-response dimension. While a few terms (e.g., defense response to Gram-positive bacterium, DNA replication) are less central, the dominant theme points to neural development coupled with growth and stress signaling.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030900","count":6},{"id":"GO:0070059","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0001843","count":5},{"id":"GO:0035329","count":4}]},{"hash":"1194616206358542442","title":"Mitochondrial dynamics and immune signaling","description":"These proteins show strong enrichment for mitochondrial organization and membrane potential regulation (inner mitochondrial membrane organization, positive regulation of mitochondrial membrane potential, stress-induced mitochondrial fusion), indicating a role in mitochondrial dynamics. At the same time, several terms point to immune and signaling pathways (TLR3 signaling, PKC signaling, T cell polarity) and to cell\u2013cell interactions (cadherin-mediated adhesion, extracellular matrix disassembly). Together, these terms suggest a cluster where mitochondrial dynamics intersect with immune signaling and cellular adhesion processes, justifying the label.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010918","count":2},{"id":"GO:0034141","count":2},{"id":"GO:0007007","count":2},{"id":"GO:0070528","count":2},{"id":"GO:1903905","count":2}]},{"hash":"1510970598768419273","title":"Nucleophagy and ubiquitin-like protein conjugation","description":"The cluster is dominated by autophagy-related terms (piecemeal microautophagy of the nucleus, late nucleophagy, CVT pathway, autophagy of mitochondrion), indicating a core autophagy theme. The inclusion of ISG15-protein conjugation, neddylation, and ufmylation suggests regulation by ubiquitin-like modifiers, pointing to a shared regulatory mechanism for these autophagy processes.","confidence":"High","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0034727","count":3},{"id":"GO:0006501","count":3},{"id":"GO:0044805","count":3},{"id":"GO:0032258","count":3},{"id":"GO:0000422","count":3}]},{"hash":"748575961738027928","title":"Nutrient stress response and detoxification","description":"The top GO terms cluster around starvation response, oxidative stress/detoxification, toxin catabolism, and amino acid/nutrient signaling, pointing to a group of proteins involved in managing nutrient stress and cellular damage; a few terms like organ regeneration and smell are outliers or broad annotations.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042594","count":4},{"id":"GO:0033591","count":3},{"id":"GO:0031100","count":3},{"id":"GO:0040008","count":3},{"id":"GO:0060316","count":3}]},{"hash":"163367667359992838","title":"Glycinergic signaling and amino acid transport","description":"The top GO terms cluster around glycine-focused synaptic activity: glycinergic synaptic transmission, regulation of glycinergic transmission, glycine secretion, and glycine import/transport, plus related amino acid transport and neurotransmitter uptake (proline transport, dopamine uptake, serotonin uptake). This suggests a coherent function group centered on glycine-mediated neurotransmission and amino acid transport, with a few unrelated terms likely representing noise. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903346","count":1},{"id":"GO:0060092","count":1},{"id":"GO:0060012","count":1},{"id":"GO:0021984","count":1},{"id":"GO:0051583","count":1}]},{"hash":"83387459344193985","title":"DNA Damage Response and Transcription Regulation","description":"The top GO terms cluster around transcriptional regulation by RNA polymerase II and DNA damage/repair responses (e.g., SOS response, double-strand break repair), suggesting a theme of transcriptional control in the context of DNA damage. A few terms (neural stimulation, learning) appear unrelated and may reflect annotation noise, but the dominant signals point to DDR-associated transcriptional regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045944","count":4},{"id":"GO:0009307","count":3},{"id":"GO:1990416","count":3},{"id":"GO:0008306","count":3},{"id":"GO:0009432","count":3}]},{"hash":"661369556376903269","title":"Cartilage and collagen ECM remodeling","description":"This cluster is enriched for collagen fibril organization, cartilage development involved in endochondral bone morphogenesis, endochondral ossification, and collagen catabolic processes, along with ECM-related activities such as integrin biosynthesis. Together these terms point to extracellular matrix assembly and remodeling in cartilage and bone formation, with some podocyte/kidney basement membrane context reflected in related terms. ","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0070208","count":1},{"id":"GO:0033034","count":1},{"id":"GO:0060351","count":1},{"id":"GO:0045112","count":1}]},{"hash":"41894420179825273","title":"Stress-Response Signaling and Development","description":"This cluster combines GO terms pointing to stress-activated signaling (p38MAPK cascade; cellular response to LPS and cadmium; ER stress\u2013induced apoptosis) with transcriptional regulation (DNA-templated transcription) and developmental contexts (retinoic acid response, chondrocyte growth, placenta development). The proteins likely participate in stress-responsive signaling that influences both immune responses and developmental processes, rather than a single precise function. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0071222","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0038066","count":3}]},{"hash":"2210250840844214428","title":"Unknown","description":"There are no GO terms or inter-protein connections to define a shared function among the six proteins; with Edges 0 and Top Terms empty, the cluster lacks any coherent biological signal, so a specific functional label cannot be assigned. The note about 20 proteins re-added by ReCIPE suggests post-processing rather than a genuine functional theme.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1483760331173325290","title":"Neurosensory signaling and behavior","description":"The top GO terms cluster around neural signaling and sensory function\u2014serotonin receptor signaling, dopamine secretion, and synaptic transmission\u2014while ion transport and sensory processing terms (sodium/potassium/chloride transport, cochlea development) align with neurosensory activity and behavior (walking, conditioned taste aversion). This suggests a cohesive module of neural signaling linked to sensory perception and motor/behavioral responses.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0050893","count":2},{"id":"GO:0007628","count":2}]},{"hash":"1730587009715660521","title":"Proteasome\u2013ubiquitin\u2013antigen processing","description":"The top terms emphasize ubiquitin ligase activity and SCF/ proteasome-mediated protein turnover, including proteasome core assembly and SCF-dependent degradation, coupled with antigen processing and presentation via MHC I. Additional signals point to NF-\u03baB\u2013related immune signaling and viral processes, linking proteostasis to immune function, with some stress-related terms. This supports a cohesive module centered on ubiquitin-proteasome\u2013driven antigen processing and related signaling.","confidence":"Medium","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051437","count":5},{"id":"GO:0009651","count":5},{"id":"GO:0002479","count":5},{"id":"GO:0010950","count":5},{"id":"GO:0038061","count":5}]},{"hash":"310901780667512837","title":"Neuronal growth signaling and axonogenesis","description":"The terms cluster around neuronal development and signaling: axonogenesis, neurotrophin TRK receptor signaling, receptor clustering, and actin remodeling\u2014all suggest roles in neurite outgrowth and neuronal wiring. Other terms like angiogenesis and LPS response point to broader signaling networks, but the strongest shared theme is neuronal growth signaling and axon formation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0042517","count":1},{"id":"GO:2001275","count":1},{"id":"GO:0043113","count":1}]},{"hash":"1887515210585555931","title":"Ubiquitin signaling and NF-\u03baB/TNF regulation","description":"The cluster is dominated by diverse ubiquitination processes (K48, K63, K6, linear) and ubiquitin-dependent proteolysis, with associated components of NF-\u03baB signaling, TNF-mediated pathways, and necroptosis regulation, suggesting a cohesive role in ubiquitin-mediated turnover and inflammatory signaling.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070534","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0070936","count":4},{"id":"GO:0085020","count":4},{"id":"GO:1903265","count":4}]},{"hash":"1125137263165431934","title":"Ubiquitin-Dependent Proteostasis and Mitochondrial Dynamics in Neurons","description":"The top GO terms point to ubiquitin-mediated proteolysis (K48/K63/K11 linkages) and ubiquitin-dependent protein catabolic processes, alongside mitochondrial regulation (membrane potential, fission) and neuronal signaling (dopamine uptake). Together these suggest a cluster focused on ubiquitin-driven protein turnover and mitochondrial maintenance in neuronal contexts.","confidence":"Medium","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1903382","count":3},{"id":"GO:0010918","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0051583","count":2},{"id":"GO:0042787","count":2}]},{"hash":"280109558312541143","title":"Unknown","description":"The GO terms cover multiple unrelated biology areas: plant developmental processes (microgametogenesis, somatic embryogenesis), insect-specific differentiation (R7 photoreceptor differentiation) and behavior (courtship), plus core lipid biosynthesis and vesicle trafficking processes. Because there isn't a single unifying function tying all terms together, the cluster cannot be given a specific functional label beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055046","count":1},{"id":"GO:0045466","count":1},{"id":"GO:0010262","count":1},{"id":"GO:0042761","count":1},{"id":"GO:0035338","count":1}]},{"hash":"1439431061011094242","title":"Unknown","description":"The GO terms are scattered across development, signaling, apoptosis, metal ion response, and more, with no single cohesive function tying the six proteins together. This diversity makes it inappropriate to assign a specific, concise function label. ","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048706","count":2},{"id":"GO:0050999","count":2},{"id":"GO:1904747","count":1},{"id":"GO:1905803","count":1},{"id":"GO:0097202","count":1}]},{"hash":"621964006975789168","title":"Chromatin modification via protein acetylation","description":"The cluster is dominated by GO terms related to chromatin regulation (subtelomeric heterochromatin formation) and widespread protein acetylation (N-terminal acetylation and various peptidyl- acetylation terms, including lysine). This suggests a shared theme around chromatin structure control and transcriptional regulation through acetylation. Some outliers like angiogenesis or melatonin biosynthesis appear in the list, but the core signal centers on chromatin-associated acetylation pathways.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":5},{"id":"GO:0001525","count":4},{"id":"GO:0019491","count":4},{"id":"GO:0030187","count":4},{"id":"GO:0017198","count":4}]},{"hash":"360672604927884256","title":"Fungal Innate Immune Signaling","description":"The dominant GO terms point to innate antifungal signaling (C-type lectin receptor signaling, cellular response to fungal origin, basophil activation, NK cell regulation) with some kidney-development annotations, suggesting the immune response to fungi as the core theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":6},{"id":"GO:0045575","count":5},{"id":"GO:0072237","count":5},{"id":"GO:0036303","count":5},{"id":"GO:0072287","count":5}]},{"hash":"847003513947716987","title":"Unknown","description":"There are no GO terms or shared functional annotations for this cluster (Top Terms list is empty) and the graph has 0 edges, so no functional pattern is evident. With only a few proteins and no interactions or enrichment signals, a confident, specific label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1191806229561229555","title":"Translational control and ubiquitin-mediated degradation","description":"The cluster centers on translation initiation and reinitiation (translation reinitiation; formation of translation preinitiation complex) alongside ubiquitin-proteasome\u2013related processes (K11-linked ubiquitination; SCF-dependent proteasomal degradation; polyubiquitination; APC-dependent catabolic process). The presence of cell-cycle\u2013associated terms (cell division) further supports a theme where protein synthesis is coordinated with targeted proteolysis during division. This suggests a cohesive role in regulating protein levels via both synthesis and degradation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0000209","count":2}]},{"hash":"1760287367881810593","title":"RNA metabolism and translation regulation","description":"The top GO terms point to multiple RNA-centric processes\u2014splicing regulation, mRNA export, modification, and stress-related stability\u2014alongside translation initiation activities (reinitiation and preinitiation complex formation) and regulatory ncRNA-mediated silencing. Together, these emphasize coordinated RNA processing and control of translation. ","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0048026","count":4},{"id":"GO:1902625","count":3}]},{"hash":"1457674980036079909","title":"Kidney and Lymphatic Morphogenesis","description":"The top terms are dominated by metanephric (kidney) morphogenesis events (proximal/distal tubule morphogenesis, ascending limb development) and lymph vessel morphogenesis, pointing to a developmental theme focused on kidney and vascular/lymphatic formation. Some immune-related terms appear but are less central to the cluster\u2019s core signal. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":3},{"id":"GO:0072237","count":3},{"id":"GO:0036303","count":3},{"id":"GO:0072287","count":3},{"id":"GO:0002223","count":3}]},{"hash":"1773530308876755791","title":"Meiotic Chromosome Cohesion and Spindle Assembly","description":"This cluster centers on meiotic chromosome dynamics and spindle assembly. The strongest terms are meiotic sister chromatid cohesion and female meiotic nuclear division, with supporting signals from DNA replication-dependent chromatin assembly, tubulin complex assembly, and tubulin folding pathways, plus NLS-mediated nuclear import, all pointing to meiosis-related chromatin organization and spindle machinery rather than unrelated processes.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":2},{"id":"GO:0001938","count":1},{"id":"GO:0006275","count":1},{"id":"GO:0045945","count":1},{"id":"GO:0006335","count":1}]},{"hash":"2122329447451512436","title":"Calcium signaling and ion homeostasis","description":"This cluster centers on Ca2+-related processes (release of sequestered Ca2+ from Golgi, calcineurin-NFAT signaling modulation, T-tubule organization) and broad ion homeostasis (Mn2+, K+), with additional context of mechanosensing (hydrostatic pressure) and related signaling that can influence development. The common theme appears to be calcium-coupled ion regulation and membrane-associated signaling.","confidence":"High","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030026","count":3},{"id":"GO:0051599","count":2},{"id":"GO:0061454","count":2},{"id":"GO:1990938","count":2},{"id":"GO:0030007","count":2}]},{"hash":"1427579621117654531","title":"Unknown","description":"The top GO terms span neural signaling (negative regulation of synaptic plasticity, fast calcium-dependent neurotransmitter exocytosis, short-term potentiation) and immune/metabolic processes (TNF regulation, T cell proliferation, fat cell differentiation), with no single, coherent function linking all proteins. Given the mixed signals and lack of a unifying pathway, a clear cluster label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904468","count":2},{"id":"GO:0031914","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0098746","count":1},{"id":"GO:1990926","count":1}]},{"hash":"2088684762859270926","title":"Developmental regulation and meiosis","description":"The terms span broad developmental processes (neural plate development, oocyte localization during egg chamber formation, renal vesicle formation, organ identity maintenance) and cell-cycle/meiotic events (regulation of cell cycle, meiotic sister chromatid cohesion, female meiotic nuclear division). There isn\u2019t a single clear pathway tying all proteins together, so the label reflects a general developmental theme with meiotic associations.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070262","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0030720","count":2},{"id":"GO:0007143","count":2},{"id":"GO:0072033","count":2}]},{"hash":"308894645540842875","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:1901976","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0034314","count":3}]},{"hash":"415162447321996775","title":"Protein folding stress response","description":"This cluster is best described as a protein folding stress response or protein quality control cluster. The most represented terms relate to response to unfolded protein, ER stress and its link to apoptosis, chaperone-cofactor dependent refolding, and negative regulation of inclusion body assembly. Together these reflect cellular proteostasis under stress. A few terms like DNA replication and fungal cell wall biosynthesis appear less related and may reflect multifunctional proteins in the set.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:1903382","count":2},{"id":"GO:1903751","count":2},{"id":"GO:0070880","count":2},{"id":"GO:0090084","count":2}]},{"hash":"995840408857010643","title":"Drosophila egg-laying and olfactory behavior regulation","description":"The cluster\u2019s GO terms center on insect behavioral regulation, especially egg-laying behaviors and olfactory-driven behavior, with additional related behavioral terms (e.g., larval locomotion, behavioral defense). While there are a few unrelated molecular terms, the dominant theme is sexually reproductive and sensory-driven behavior in insects, suggesting a cohesive functional cluster around behavior regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045434","count":1},{"id":"GO:0048042","count":1},{"id":"GO:0002209","count":1},{"id":"GO:1901045","count":1},{"id":"GO:0008345","count":1}]},{"hash":"43468696313141281","title":"RNA Splicing and mRNA Processing Regulators","description":"Based on the GO terms, the proteins are primarily linked to RNA splicing, mRNA processing, and spliceosome dynamics (spliceosomal complex disassembly), with additional annotations for transcription regulation. This suggests a core function in RNA processing and splicing rather than a single developmental or signaling pathway. Some muscle-related terms appear, but they likely reflect broader regulatory roles or annotation overlap rather than a cohesive muscle-specific function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040027","count":1},{"id":"GO:0032091","count":1},{"id":"GO:0006397","count":1},{"id":"GO:1904876","count":1},{"id":"GO:0008380","count":1}]},{"hash":"949908363161573374","title":"Neuronal signaling and ion homeostasis","description":"The terms converge on signal transduction in neural contexts (neurotrophin TRK signaling, STAT phosphorylation, receptor clustering, cocaine response) together with ion homeostasis (potassium, magnesium, manganese). While there are a few outliers (angiogenesis, LPS response), the cluster most strongly suggests neuronal signaling coupled with ion regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006813","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0030026","count":1},{"id":"GO:0010960","count":1},{"id":"GO:0001525","count":1}]},{"hash":"792584531816734247","title":"Energy metabolism and hormonal stress responses","description":"The proteins show enrichment in central energy pathways (glycolysis, ATP biosynthesis) and glucose- and hormone-signaling responses (insulin, epinephrine), complemented by stress-related terms (heat, hypoxia) and related catabolic processes, pointing to a cluster focused on metabolic energy production modulated by hormonal and stress signaling.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046392","count":2},{"id":"GO:0010431","count":2},{"id":"GO:0061621","count":2},{"id":"GO:0009749","count":2},{"id":"GO:0071872","count":2}]},{"hash":"1994528055621902738","title":"Neuronal ubiquitination and synaptic transport","description":"This cluster is characterized by GO terms centered on ubiquitination (protein ubiquitination, K63/K48-linked ubiquitination, ubiquitin-dependent protein catabolic process) and neuronal/synaptic functions (excitatory postsynaptic potential, anterograde synaptic vesicle transport, regulation of neuron apoptotic process). Together, these terms suggest proteins involved in ubiquitin-mediated regulation of synaptic components and vesicle trafficking in neurons, supporting a label focused on neuronal ubiquitination and synaptic transport.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0070534","count":1},{"id":"GO:0042787","count":1}]},{"hash":"2030833931858836556","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006369","count":5},{"id":"GO:1903241","count":3},{"id":"GO:0070870","count":3},{"id":"GO:0043629","count":3},{"id":"GO:0035640","count":3}]},{"hash":"691698917056115299","title":"Centrosome/Cilium-Related Cell Cycle and Development","description":"The dominant GO signals point to centrosome and microtubule organization (microtubule anchoring at centrosome; mitotic spindle transition) and ciliogenesis/development (non-motile cilium assembly; left-right asymmetry determination), suggesting a cohesive role in cell division and ciliary-related development. Some stress/immune-related terms appear but do not define the core function of the cluster.","confidence":"High","size":5,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":1},{"id":"GO:0071908","count":1},{"id":"GO:0071276","count":1},{"id":"GO:0016570","count":1},{"id":"GO:0061087","count":1}]},{"hash":"710241456716702514","title":"Metabolic and redox processes","description":"The top GO terms cluster around metabolism-related processes (lipoate, thiamine, valine, alkane catabolism) and oxidative stress/detoxification (oxidation-reduction, cellular oxidant detoxification). A few terms suggest development or neuronal aspects, but their lower counts mean the dominant theme is metabolism with redox balance.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0032496","count":2},{"id":"GO:0009106","count":2},{"id":"GO:0098869","count":2}]},{"hash":"735643276861376377","title":"Signaling Regulation and Growth in Multicellular Tissues","description":"The Top Terms include multicellular organism growth, thyroid hormone receptor signaling, regulation of protein kinase activity, and NF-kappaB signal transduction, along with LPS response and epithelial differentiation. Together these suggest a module coordinating growth signals and intracellular signaling in multicellular contexts, rather than a single specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0043124","count":3},{"id":"GO:0051291","count":2},{"id":"GO:0045859","count":2},{"id":"GO:0071222","count":2}]},{"hash":"389680850250361554","title":"Neural and Multicellular Development","description":"These proteins are enriched for development-related GO terms, especially nervous system and forebrain development, along with skeletal and general multicellular organism development, and DNA-templated transcription. The dominant theme is developmental regulation of neural tissues, with transcriptional control supporting that process; a few stress/immune terms appear as secondary signals.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0071276","count":3}]},{"hash":"727246425243684925","title":"Translation and ribosome biogenesis","description":"The cluster is dominated by GO terms related to protein synthesis and ribosome assembly, including translation, translational initiation, cytoplasmic translational termination, ribosomal small subunit biogenesis, maturation of SSU-rRNA, and export of ribosomal subunits, with additional terms pointing to specialized translation (selenocysteine incorporation) and RNA processing linked to ribosome function.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000462","count":1},{"id":"GO:0006413","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0046677","count":1}]},{"hash":"618710720183814641","title":"Neural and Glial Cell Apoptosis","description":"The top GO terms are neuron apoptotic process and glial cell apoptotic process, indicating that the proteins cluster around neural cell apoptosis. The presence of DNA damage response and hydrogen peroxide response suggests stress- and damage-induced signaling that can trigger apoptosis. Some terms like response to amino acid, lipopolysaccharide, and antibiotic appear as broader stress or immune-related responses, but they do not dominate the profile; overall the cluster centers on neural cell apoptosis and associated stress signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051402","count":2},{"id":"GO:0034349","count":2},{"id":"GO:0006974","count":1},{"id":"GO:0042542","count":1},{"id":"GO:0043200","count":1}]},{"hash":"2156421054432802503","title":"Diverse solute transmembrane transport","description":"The GO terms indicate transport of a wide range of solutes (ions, sugars, vitamins, xenobiotics, osmotic stress-related substrates) across membranes, pointing to a common theme of membrane transport processes rather than a single substrate, so the cluster likely comprises diverse solute transport activities.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0097080","count":2}]},{"hash":"630456822863858967","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":1},{"id":"GO:0051259","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0032781","count":1}]},{"hash":"509041606482549601","title":"Chromatin organization and histone modification","description":"The top terms cluster around chromatin biology\u2014nucleosome assembly and positioning, histone H3 methylation marks, heterochromatin organization, and localization to chromatin\u2014pointing to a protein group involved in chromatin structure and epigenetic regulation, even with some obsolete GO annotations. This suggests roles in establishing and maintaining chromatin states and nucleus organization.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":5},{"id":"GO:0006334","count":5},{"id":"GO:0016584","count":5},{"id":"GO:0097298","count":5},{"id":"GO:0098532","count":5}]},{"hash":"1298292735107623519","title":"Cytokine-mediated innate antiviral defense","description":"The top GO terms are dominated by innate immune and antiviral functions (cytokine-mediated signaling pathway, innate immune response, defense response to virus), suggesting the proteins cluster around innate immune signaling and antiviral defense. The few metabolic or signaling modifiers present at low counts are likely incidental. Overall, the primary theme is innate immune defense against viruses.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019221","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051607","count":2},{"id":"GO:2000010","count":1},{"id":"GO:0090038","count":1}]},{"hash":"1385511316118756704","title":"ER-Golgi trafficking and secretory pathway","description":"The top GO terms cluster around ER-to-Golgi vesicle transport, SNARE disassembly, reticulophagy, and the constitutive secretory pathway, all pointing to vesicle trafficking and maintenance of the ER\u2013Golgi secretory network. Although translation-related terms appear, the strongest shared theme is vesicular transport and secretion related to ER function, including ER\u2013Golgi dynamics and membrane contact sites. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0035494","count":2}]},{"hash":"1573943926990796409","title":"Unknown","description":"The GO terms cover immune response, cell adhesion, macrophage chemotaxis, growth factor signaling, sperm binding, vascular development, heart morphogenesis, blood coagulation, and hormonal response. There is no single clear function or pathway that ties these terms together across the proteins, so a coherent cluster label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0002455","count":1},{"id":"GO:0010758","count":1},{"id":"GO:0048012","count":1},{"id":"GO:0007339","count":1}]},{"hash":"1303646508647899824","title":"Steroid Hormone Biosynthesis","description":"Dominant GO terms describe biosynthetic processes for steroid hormones (cortisol, testosterone, aldosterone, progesterone), giving a cohesive functional theme for the cluster. The presence of unrelated terms (photosynthesis, vancomycin biosynthesis, insecticide metabolism, uterus development) suggests mixed annotations, so the label reflects the main signal but with only Medium confidence due to the outliers.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0015979","count":2},{"id":"GO:0033072","count":1},{"id":"GO:0034651","count":1},{"id":"GO:0061370","count":1}]},{"hash":"1464646162293961046","title":"Flavonoid Glycosylation and Lignin Biosynthesis","description":"The cluster centers on flavonoid biosynthetic processes (kaempferol and cyanidin glucoside biosynthesis) and lignin metabolism, with related glycosylation and carbohydrate metabolism terms. This points to a cohesive theme of phenylpropanoid-derived secondary metabolism and sugar decoration of flavonoids.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009808","count":1},{"id":"GO:0033485","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0070980","count":1},{"id":"GO:0008360","count":1}]},{"hash":"505534448611346140","title":"Embryonic skeletal development and axon guidance","description":"These GO terms cluster around embryonic development with emphasis on skeletal formation (negative regulation of osteoblast differentiation, negative regulation of bone remodeling, somite/sclerotome development) and neural patterning (axon guidance, dendrite guidance, axonogenesis). The overlap of somite/sclerotome-related skeletal development with neural guidance processes suggests a theme of early embryonic tissue patterning, combining skeletal and nervous system formation. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045668","count":2},{"id":"GO:0090246","count":1},{"id":"GO:0061053","count":1},{"id":"GO:0070983","count":1},{"id":"GO:0033564","count":1}]},{"hash":"1059329068464657741","title":"Adrenergic GPCR signaling and blood pressure regulation","description":"The top GO terms cluster around GPCR pathways that regulate adenylate cyclase activity and vascular tone, including norepinephrine/epinephrine\u2013mediated vasodilation and related biogenic amine signaling (e.g., octopamine/tyramine) and angiotensin-related vasodilation, pointing to a cardiovascular regulatory theme. Some terms (e.g., neuronal migration and electron transport) appear as outliers, but the dominant signal links adrenergic/GPCR signaling to blood pressure regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":2},{"id":"GO:0010579","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0045777","count":2},{"id":"GO:0031635","count":1}]},{"hash":"1461465704936255403","title":"Amino acid transport and GABA biosynthesis","description":"The cluster's terms are dominated by transmembrane transport of amino acids (glutamate, threonine, serine, D-aspartate) and a GABA biosynthetic process, which together point to amino acid uptake/metabolism and neurotransmitter synthesis. The other terms (dermatan sulfate proteoglycan metabolism, ureteric bud formation) appear isolated and likely represent annotation noise, not core functions of the cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055085","count":1},{"id":"GO:0051938","count":1},{"id":"GO:0015826","count":1},{"id":"GO:0009449","count":1},{"id":"GO:0070779","count":1}]},{"hash":"100431869224040769","title":"Glutamatergic Synaptic Transmission","description":"The top GO terms point to excitatory synaptic activity: synaptic transmission, glutamatergic signaling, receptor clustering, and neurotrophin/TRK receptor signaling, indicating a core group involved in glutamatergic neurotransmission. A few terms (GM-CSF stimulus, LPS response, angiogenesis, actin binding) reflect broader signaling contexts or interactions but do not override the central neuronal-synaptic theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0071222","count":2}]},{"hash":"2089770035054394697","title":"Kidney tubule morphogenesis and immune signaling","description":"This cluster prominently features metanephric tubule development (proximal/distal tubule morphogenesis, ascending limb development) pointing to kidney development, alongside several immune-related terms (basophil activation, lectin receptor signaling, NK cell chemotaxis, fungal-origin response), suggesting a mixed theme of organ morphogenesis with immune signaling involvement. The dominant kidney development terms exist with supportive immune pathways, so the label reflects a dual-function cluster rather than a single narrow function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":4},{"id":"GO:0072237","count":4},{"id":"GO:0036303","count":4},{"id":"GO:0072287","count":4},{"id":"GO:0002223","count":4}]},{"hash":"2162392694775615758","title":"Potassium Transport and Membrane Potential Regulation","description":"The top GO terms are dominated by potassium ion transport, transmembrane transport, intracellular potassium homeostasis, and multiple aspects of membrane potential regulation (resting potential, stabilization, and repolarization), suggesting the proteins cluster around potassium channels/transporters and electrophysiological homeostasis. A few unrelated terms (like saliva secretion or T cell signaling) appear but do not override the central theme. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046541","count":2},{"id":"GO:0050862","count":1},{"id":"GO:0030322","count":1},{"id":"GO:1903640","count":1},{"id":"GO:0006813","count":1}]},{"hash":"1908013435029596592","title":"Neurotransmitter and hormone signaling in vascular regulation","description":"This cluster centers on signaling pathways mediated by various amine and opioid receptors (dopamine, octopamine/tyramine, norepinephrine/epinephrine, opioid signaling) and their links to vasodilation and blood pressure regulation, suggesting a core theme of neuroendocrine control of cardiovascular function. While there are also terms related to neural development and organ morphogenesis, the strongest common thread is signaling that modulates vascular physiology.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031635","count":1},{"id":"GO:0008284","count":1},{"id":"GO:0002025","count":1},{"id":"GO:0022900","count":1},{"id":"GO:0021853","count":1}]},{"hash":"290081033470153824","title":"Unknown","description":"The top GO terms mix neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration) with broad signaling and immune-related processes (insulin receptor signaling, T cell receptor signaling, LPS response, angiogenesis, STAT phosphorylation). There isn\u2019t a clear, single theme connecting these functions, so a cohesive specific label isn\u2019t justifiable.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0021697","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0048679","count":4}]},{"hash":"696941230311460202","title":"ER-to-Golgi Transport and ER Stress Response","description":"The GO terms point to COPII-coated vesicle budding, ER localization, and unfolded protein response, indicating roles in ER export to the Golgi and ER stress signaling. Some viral-host interaction terms are present but do not define the core function; the cluster mainly reflects secretory pathway trafficking and ER stress management.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":1},{"id":"GO:0006987","count":1},{"id":"GO:0044828","count":1},{"id":"GO:0006874","count":1},{"id":"GO:0044829","count":1}]},{"hash":"511789948845219045","title":"ER Stress and ER-to-Golgi Trafficking","description":"The top terms point to ER-focused biology: COPII vesicle budding, ER localization, and ER unfolded protein response, along with calcium homeostasis; mitochondrial permeabilization suggests stress-induced apoptosis. Taken together, the cluster seems to reflect ER stress response coupled with ER-to-Golgi trafficking, with some hints of host antiviral response context.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":1},{"id":"GO:0006987","count":1},{"id":"GO:0044828","count":1},{"id":"GO:0006874","count":1},{"id":"GO:0044829","count":1}]},{"hash":"315602142758466024","title":"Unknown","description":"The top terms span antibiotic catabolic processes and cell migration/development signals (including heart development and VEGF-regulated migration), with no clear, cohesive functional theme across the proteins. The mix of unrelated terms and an absence of internal connectivity suggests no single interpretable function for this cluster. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019876","count":1},{"id":"GO:0030655","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0033252","count":1},{"id":"GO:0071976","count":1}]},{"hash":"267203685857558744","title":"Oxidative and UV Stress Response with Transport Regulation","description":"The proteins are enriched for oxidative stress/ROS terms (negative regulation of ROS metabolism, response to hydrogen peroxide) and UV-A/gamma radiation responses, plus terms related to transport regulation (negative regulation of intracellular transport, anterograde axonal protein transport), hinting at a theme of stress response linked to cellular transport modulation. Confidence is moderate given the diverse terms and lack of direct interaction data.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":2},{"id":"GO:0042542","count":2},{"id":"GO:0006936","count":2},{"id":"GO:0070141","count":2},{"id":"GO:0032387","count":2}]},{"hash":"1257722975011877610","title":"Glycogen Metabolism Regulation","description":"The sole GO term available, negative regulation of glycogen catabolic process, points to a theme of inhibiting glycogen breakdown, suggesting these proteins may collectively regulate glycogen metabolism; however, with only one term and a small cluster, this support is modest.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045818","count":1}]},{"hash":"929870140383081200","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0006977","count":2},{"id":"GO:0009307","count":2},{"id":"GO:0000472","count":2}]},{"hash":"42880872365992820","title":"Regulators of signaling and cell migration","description":"Top GO terms point to regulatory roles in signaling (negative regulation of VEGF receptor signaling; negative regulation of STAT tyrosine phosphorylation) as well as processes involving cell movement (intestinal epithelial cell migration; regulation of axon regeneration). Additional terms reference broader regulatory effects on growth factor signaling and immune-related activity (granzyme B production) and structural podocyte function (slit diaphragm assembly). The common thread is modulation of signaling pathways that influence cell behavior, rather than a single specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":3},{"id":"GO:0000742","count":2},{"id":"GO:0042524","count":2},{"id":"GO:0048679","count":2},{"id":"GO:0061582","count":2}]},{"hash":"2181134299226802887","title":"Notch Signaling in Development","description":"The cluster contains both positive and negative regulation of Notch signaling and multiple development-related processes across tissues (follicle, intestine, segmentation), pointing to Notch-mediated developmental regulation as the common theme.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007143","count":1},{"id":"GO:0032092","count":1},{"id":"GO:0002315","count":1},{"id":"GO:0016267","count":1},{"id":"GO:1902367","count":1}]},{"hash":"229788507004137803","title":"Mitochondrial dynamics and immune signaling","description":"The cluster centers on mitochondria-related processes (membrane potential regulation, inner membrane organization, stress-induced fusion), indicating coordinated mitochondrial dynamics. It also includes innate and adaptive signaling elements (TLR3 signaling, PKC signaling, T cell polarity) and adhesion/remodeling activities (cadherin-mediated adhesion and extracellular matrix disassembly), suggesting a network where mitochondrial state interfaces with immune signaling and cell\u2013cell interactions.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010918","count":3},{"id":"GO:0034141","count":3},{"id":"GO:0007007","count":3},{"id":"GO:0070528","count":3},{"id":"GO:1903905","count":3}]},{"hash":"1431008777934066074","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitination and protein catabolic processes (e.g., ubiquitin-dependent protein catabolic process, K48-linked ubiquitination, autoubiquitination) and ERAD, with additional hints from receptor turnover and vesicle trafficking terms, all pointing to proteostasis and quality control via ubiquitin-mediated degradation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0030433","count":1},{"id":"GO:1900095","count":1},{"id":"GO:0070936","count":1}]},{"hash":"1398563856775707080","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by ribosome-related processes: ribosome biogenesis, cytoplasmic translation, ribosomal subunit export, and tRNA modification, indicating a core role in assembling and translating ribosomes for protein synthesis. The presence of cell division and septum assembly terms suggests some coupling to growth, but the ribosome-focused terms are the strongest shared theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0042274","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0090529","count":2},{"id":"GO:0042254","count":2}]},{"hash":"2161567345863172826","title":"Golgi\u2013Endosome Trafficking and Recycling","description":"The GO terms indicate intracellular transport centered on the Golgi and endosomal pathways, including retrograde transport from endosome to Golgi, Golgi retention, and endocytic recycling, suggesting a cohesive Golgi-endosome trafficking function for these proteins.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":1},{"id":"GO:0042147","count":1},{"id":"GO:0045053","count":1},{"id":"GO:1990126","count":1}]},{"hash":"1240394239403521925","title":"Neuronal signaling and cytoskeletal dynamics","description":"The top GO terms cluster around neuronal signaling and cytoskeleton-related processes, including axonogenesis, neurotrophin TRK receptor signaling, receptor clustering, and regulation of actin filament binding, suggesting a role in neurite outgrowth and cytoskeletal remodeling. While there are additional terms like angiogenesis and lipopolysaccharide response, these are less central to the core theme; overall, the strongest signal points to neuronal signaling coupled with cytoskeletal dynamics.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0042517","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0043113","count":2}]},{"hash":"1875218254180325538","title":"Nucleotide and purine metabolism","description":"The cluster centers on nucleotide-related processes: AMP biosynthetic process, nucleoside metabolic process, hypoxanthine biosynthetic process, and urate biosynthetic process, plus general phosphorylation, pointing to purine/nucleotide metabolism as the common theme. Some developmental and other terms appear but are less cohesive with the dominant metabolic signals. This suggests the proteins share a function linked to nucleotide and purine metabolism rather than a single development pathway. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006167","count":1},{"id":"GO:0031100","count":1},{"id":"GO:0060348","count":1},{"id":"GO:0009116","count":1},{"id":"GO:0016310","count":1}]},{"hash":"1769063542536561337","title":"Apoptosis and Signaling Regulators","description":"The GO terms show enrichment for regulation of apoptosis (apoptotic processes, intrinsic neuronal apoptotic signaling, ER stress-related), along with regulation of signaling pathways such as canonical Wnt signaling, GTPase activity, and JNK cascade, suggesting proteins that modulate cell survival and stress-response signaling. Some terms (fungal beta-glucan biosynthesis) appear unrelated and may be annotation noise; overall, the cluster centers on balancing pro- and anti-apoptotic signaling through key pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0006915","count":2},{"id":"GO:1903382","count":1}]},{"hash":"143746037831699597","title":"Membrane transporters linked to sensory perception","description":"This cluster\u2019s terms center on sodium ion transport/homeostasis and diverse sensory modalities (taste such as sour and salty, mechanosensation for touch, and temperature/pain perception), suggesting membrane-associated transporters/receptors involved in neuronal signaling and sensory perception. A few apoptosis-related terms appear but are not prominent, so the core theme is sensory-related membrane transport.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043654","count":1},{"id":"GO:0015917","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0035725","count":1},{"id":"GO:1905789","count":1}]},{"hash":"423423540983116871","title":"Lung branching morphogenesis and ECM remodeling","description":"The top GO terms converge on lung development, specifically epithelial tube branching morphogenesis, dichotomous subdivision of terminal units in the lung, and basement membrane/collagen catabolic processes, indicating extracellular matrix remodeling during lung morphogenesis. Some terms like bradykinin/neuropeptide catabolism and thyroid hormone response may reflect broader proteolytic or signaling roles, but the dominant theme is ECM remodeling tied to lung branching. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":2},{"id":"GO:0034769","count":2},{"id":"GO:0051603","count":2},{"id":"GO:0001913","count":2},{"id":"GO:0030574","count":2}]},{"hash":"205255625630811358","title":"Unknown","description":"The cluster shows a mix of development-related GO terms across neural/glial differentiation, ocular/retinal and renal morphogenesis, germline development, and immune signaling, with only a couple directly tied to neural development. The absence of a unifying theme or clearly cohesive function, combined with the small cluster size, makes it inappropriate to assign a specific functional label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021861","count":2},{"id":"GO:0021943","count":2},{"id":"GO:0072197","count":1},{"id":"GO:0007140","count":1},{"id":"GO:0046533","count":1}]},{"hash":"662726199423417061","title":"Mitotic Cell Cycle and Cytoskeleton","description":"The prominent GO terms point to mitotic processes (cell division, cell cycle, G2/M transition, chromosome segregation) and cytoskeletal organization (microtubule network, septin ring). Ubiquitin-dependent protein catabolic process indicates regulation of mitotic progression through protein turnover. Together they describe a cohesive module of mitosis coupled with cytoskeletal dynamics.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2},{"id":"GO:2000766","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0007059","count":1}]},{"hash":"1829597721594444710","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms center on ubiquitination (K48- and K6-linked) and ubiquitin-dependent protein catabolic processes, including autoubiquitination, pointing to regulated protein turnover. Related signaling pathways (TNF, JNK) and apoptosis regulation are consistent with ubiquitin-mediated stress responses. A couple of terms (e.g., V(D)J recombination, histone regulation) are less central to this theme, but the dominant pattern supports proteostasis via ubiquitin tagging and proteolysis.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070936","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0070512","count":2},{"id":"GO:0085020","count":2},{"id":"GO:0033151","count":2}]},{"hash":"343330155525576304","title":"Meiosis and Oocyte Maturation","description":"The terms cluster around meiotic spindle assembly in female meiosis I, oocyte maturation, and ubiquitin-proteasome\u2013mediated protein turnover, with microtubule polymerization as a core mechanism. This points to a shared function in meiosis and early oocyte development; some terms are broader or developmental, but the dominant pattern is meiosis-related regulation in oocytes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0021678","count":2},{"id":"GO:0021993","count":2},{"id":"GO:0070544","count":2}]},{"hash":"2209806102432318618","title":"ER membrane and nuclear envelope organization","description":"The GO terms cluster around ER structure and its relationship with the nuclear envelope and membranes: ER tubular network organization, ER inheritance, ER-dependent peroxisome organization, protein transport into membranes, nuclear pore complex assembly, and mitotic nuclear membrane reassembly. Some terms like taste perception and ABA response appear as noise, but the dominant theme is ER membrane dynamics and nuclear envelope biology.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032596","count":1},{"id":"GO:0034976","count":1},{"id":"GO:0050916","count":1},{"id":"GO:0051292","count":1},{"id":"GO:0071786","count":1}]},{"hash":"2294771362929691435","title":"Plant cell wall remodeling and plasmodesmata organization","description":"This cluster is dominated by GO terms related to plant-type cell wall modification, regulation of cellulose biosynthesis, and plasmodesma organization, indicating a shared function in plant cell wall remodeling and intercellular connectivity. While a few terms reference animal development and immune responses, the strongest signals are plant-specific.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":2},{"id":"GO:2001009","count":2},{"id":"GO:0009663","count":2},{"id":"GO:0071347","count":1},{"id":"GO:0000272","count":1}]},{"hash":"2221713683400411441","title":"Neural signaling and sensory behavior","description":"The proteins are annotated with GO terms centered on neural communication, sensory processing, and behavior (serotonin signaling, dopamine secretion, histamine response, cochlea development, taste aversion, walking, micturition), suggesting a cohesive theme of neurosensory signaling and response to stimuli.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":1},{"id":"GO:0043200","count":1},{"id":"GO:0050893","count":1},{"id":"GO:0007628","count":1},{"id":"GO:2001226","count":1}]},{"hash":"451024728500336283","title":"Ribosome Biogenesis and Translation Regulation","description":"The top GO terms cluster around ribosome production and protein synthesis, including translation, maturation of SSU-rRNA, ribosomal small subunit biogenesis/assembly, and overall ribosome biogenesis, as well as regulation of translation. Peripheral terms such as response to virus and positive regulation of the cell cycle are less central to the cluster\u2019s core function. Therefore, the label captures both the assembly of the small ribosomal subunit and the control of translation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0030490","count":2},{"id":"GO:0045787","count":1},{"id":"GO:0009615","count":1},{"id":"GO:0006417","count":1}]},{"hash":"1793033093040806122","title":"Unknown","description":"These four proteins are linked to a mix of GO terms, including tRNA wobble modification, diphthamide formation, mitochondrial events (cytochrome c release and fusion), peroxisome organization, and various signaling pathways. There is no single cohesive function or pathway that unites these terms, so a specific label cannot be assigned.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007117","count":1},{"id":"GO:0002098","count":1},{"id":"GO:0017183","count":1},{"id":"GO:0070493","count":1},{"id":"GO:1900063","count":1}]},{"hash":"2103087393551804444","title":"Neuromodulation of insect behavior","description":"The GO terms center on behavioral regulation and sensory processing, including cellular responses to temperature, pain perception, and various reproductive and locomotor behaviors (egg-laying regulation, receptivity, larval movement) as well as an opioid receptor signaling pathway, all pointing toward neuromodulatory control of behavior rather than a single metabolic or structural function. This suggests these proteins may contribute to how organisms modulate behavior in response to internal and external cues. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0045434","count":1},{"id":"GO:0048042","count":1}]},{"hash":"367538330987936770","title":"Unknown","description":"The terms include cellular response to cadmium ion, regulation of STAT tyrosine phosphorylation, regulation of axon regeneration, intestinal epithelial cell migration, regulation of growth hormone secretion, granzyme B production, CD8-positive T cell proliferation, and slit diaphragm assembly. This mix spans metal stress responses, immune signaling, neural and epithelial processes, and kidney barrier structure, with no single cohesive function connecting all proteins. Therefore a specific, representative label cannot be confidently assigned.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0042524","count":2},{"id":"GO:0048679","count":2},{"id":"GO:0061582","count":2},{"id":"GO:2001275","count":2}]},{"hash":"1944775848354023849","title":"Neuronal development and calcium signaling","description":"Most of the top GO terms point to neuronal development and synaptic function, including axonogenesis, retinal bipolar neuron differentiation, and neurotransmitter secretion. Calcium signaling terms (detection of calcium ion and calcium-release channel regulation) reinforce this theme, suggesting a focus on neuronal differentiation and calcium-dependent signaling. A few terms are broader (angiogenesis, cytoskeletal transport, transcription regulation, cell proliferation) but do not dominate, so the label emphasizes neuronal development and calcium-mediated signaling.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0005513","count":1},{"id":"GO:0060316","count":1},{"id":"GO:0008284","count":1},{"id":"GO:0019749","count":1}]},{"hash":"815210730225717284","title":"Unknown","description":"The top GO terms cover several unrelated processes (morphine/response to pain, negative regulation of inflammation, calcium detection and calcium-channel activity, meiotic DNA break formation/repair, transcription termination, and lung development) with only four proteins and a single edge, indicating weak connectivity and no clear shared function. Because there is no single dominant theme tying the proteins together, a coherent, specific label isn\u2019t apparent.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":4},{"id":"GO:0050728","count":4},{"id":"GO:0005513","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0010780","count":2}]},{"hash":"1763590792544572549","title":"Negative regulation of signaling pathways","description":"The prominent terms emphasize negative regulation of signaling cascades (ERK cascade, T cell receptor signaling, interferon signaling) and proliferation control, along with neural development terms (Bergmann glial differentiation, cerebellar cortex formation). This suggests the cluster groups proteins that modulate signaling pathways across neural and immune contexts rather than a single highly specific process.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0048679","count":2},{"id":"GO:0060336","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0060020","count":2}]},{"hash":"562401532704005799","title":"Dopaminergic Neural Signaling and Sensory Perception","description":"The cluster is dominated by neural and sensory terms: visual perception/learning, dopaminergic synaptic transmission, and cocaine-related behavioral responses, with ERK1/2 signaling often linked to neuronal activity. While a few terms reference immune or developmental processes (prostaglandin response, dsRNA response, macrophage chemotaxis, heart development), the strongest signal points to neural signaling and sensory processing with reward-related modulation.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0043330","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0048148","count":3}]},{"hash":"709190199001792275","title":"Olfactory Perception and Behavior","description":"The top GO terms point to olfactory sensing and response, with olfactory behavior and detection of chemical stimuli in sensory perception, indicating the proteins cluster around smell-related pathways and responses.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042048","count":1},{"id":"GO:0050907","count":1}]},{"hash":"402039882275163917","title":"Cerebellar development and synapse formation","description":"The top GO terms are dominated by cerebellar-specific development and synaptic organization (cerebellar cortex formation, Bergmann glial differentiation, dendritic spine morphogenesis, and protein localization to synapse), pointing to a shared role in cerebellar neural development and synaptogenesis. Some insulin-associated terms appear but are not central to the cluster\u2019s theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0060997","count":3},{"id":"GO:0035418","count":3},{"id":"GO:0008285","count":3}]},{"hash":"1358347613214591331","title":"Unknown","description":"No GO terms are provided for this cluster, and there are no edges or terms to guide a functional label. With four proteins and no shared enriched terms, a reliable common function cannot be inferred, so Unknown was chosen.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"558291735163059636","title":"Post-transcriptional RNA processing and splicing regulation","description":"The GO terms emphasize events after transcription: mRNA stability under stress, ncRNA-mediated gene silencing, spliceosome-driven and alternative splicing regulation, mRNA export, and RNA modification. Together these point to a coherent module of post-transcriptional control, including splicing regulation and RNA maturation/transport, rather than transcriptional initiation. ","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:1902625","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1118648772125197901","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006289","count":2},{"id":"GO:0042769","count":2},{"id":"GO:0006294","count":2},{"id":"GO:0006293","count":2},{"id":"GO:0006295","count":2}]},{"hash":"2244095782280178399","title":"Ion transport and calcium signaling in excitable cells","description":"The terms cluster around ion homeostasis (sodium/potassium transport, electrochemical gradient maintenance), intracellular calcium dynamics (calcium release from Golgi and calcium-dependent signaling), and associated structures (T-tubule organization) that are characteristic of excitable tissues like muscle and nerve cells. A few terms (e.g., vestibulocochlear nerve formation) hint at related sensory functions, but the dominant theme is ion transport coupled to calcium signaling.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051599","count":1},{"id":"GO:0061454","count":1},{"id":"GO:1990938","count":1},{"id":"GO:0030007","count":1},{"id":"GO:0070885","count":1}]},{"hash":"1277236313490294559","title":"Ubiquitin-Mediated Immune Signaling","description":"This cluster is dominated by ubiquitination-related GO terms (protein ubiquitination, ubiquitin-dependent proteolysis, K48- and K6-linked ubiquitination, autoubiquitination) alongside immune-related terms (adaptive immune response, V(D)J recombination, TNF signaling, regulation of apoptosis). The shared theme suggests proteins involved in tagging substrates for degradation and modulating immune signaling pathways, linking ubiquitin dynamics to immune processes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0070936","count":1},{"id":"GO:0070512","count":1},{"id":"GO:0085020","count":1}]},{"hash":"1592671046473307460","title":"Unknown","description":"These GO terms cover immune response to lipopolysaccharide, transcriptional regulation, p38 MAPK signaling, retinoic acid response, and development in reproductive tissues, adipogenesis, and pancreatic secretion. They do not point to a single coherent function or pathway that ties all proteins together, so a precise, representative label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0060068","count":3},{"id":"GO:0043433","count":3}]},{"hash":"1182809188303184197","title":"Developmental transcriptional regulation","description":"The cluster shows GO terms that emphasize transcriptional control (negative regulation of transcription by RNA Pol II; signal transduction involved in regulation of gene expression) along with diverse developmental processes (ectoderm formation, spinal cord development, mesodermal fate specification, heart-related development, odontogenesis, etc.). This points to proteins that regulate gene expression during embryonic development across multiple tissues, rather than a single pathway. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0023019","count":2},{"id":"GO:0035852","count":2},{"id":"GO:0001705","count":2},{"id":"GO:0021516","count":2}]},{"hash":"425387179253726655","title":"Unknown","description":"The GO terms cover immune response to lipopolysaccharide, organism growth, hormone signaling, lysosomal enzyme secretion, NF-kappaB regulation, circadian gene expression, and development; these do not converge on a single coherent function for the four proteins, so a concise, specific label cannot be reliably assigned.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0035264","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0090340","count":3},{"id":"GO:0043124","count":3}]},{"hash":"1690413570955205969","title":"Post-transcriptional mRNA processing and translation control","description":"The top GO terms cluster around mRNA stability, export, splicing regulation, mRNA modification, and various layers of translation control (reinitiation, IRES-dependent initiation, and miRNA-mediated silencing), all pointing to a post-transcriptional gene expression regulatory module, potentially stress-responsive.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":3},{"id":"GO:1902625","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001825","count":2},{"id":"GO:1903586","count":2}]},{"hash":"381462765336409778","title":"Stress-Driven Gene Expression and Cell Fate Regulation","description":"The top GO terms point to core gene-expression machinery (translation, rRNA transcription) and timing of expression (circadian regulation) together with cell fate control processes (cell cycle regulation, p53-mediated apoptotic signaling, anoikis) and a metabolic stress response (glucose starvation). This suggests a cluster centered on how cells regulate gene expression under stress and decide between survival, apoptosis, or differentiation cues, hence the chosen label.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0042149","count":1},{"id":"GO:0009303","count":1},{"id":"GO:0071158","count":1},{"id":"GO:0072332","count":1}]},{"hash":"996540849351409409","title":"TGF-\u03b2/BMP pathway regulators","description":"This cluster is dominated by GO terms connected to TGF-\u03b2/BMP signaling, including negative regulation of BMP signaling, cellular response to TGF-\u03b2, and SMAD-related processes, as well as peptidyl-threonine dephosphorylation which points to phosphatase-mediated modulation of signaling. A few terms appear unrelated (photosystem stoichiometry adjustment, germ-line masculinization), suggesting some noise, but the core themes converge on regulation and signal transduction within the TGF-\u03b2/BMP axis.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035970","count":1},{"id":"GO:0042006","count":1},{"id":"GO:0080005","count":1},{"id":"GO:0010991","count":1},{"id":"GO:0030512","count":1}]},{"hash":"2167392660351898882","title":"Neuronal growth signaling and cytoskeletal dynamics","description":"The top GO terms cluster around receptor tyrosine kinase\u2013mediated signaling (TRK signaling), axonogenesis, receptor clustering, angiogenesis, and actin filament binding, all indicative of growth-factor\u2013driven neural development and cytoskeletal remodeling. While some terms (lipopolysaccharide response, meiosis spindle regulation) are less coherent with this theme, the dominant pattern points to signaling and structural changes driving neuronal growth and connectivity.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0042517","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0043113","count":4}]},{"hash":"373373968778010197","title":"Chromosome Segregation and Spindle Checkpoint Regulation","description":"This cluster centers on cell division processes: sister chromatid cohesion and biorientation, establishment of protein localization to chromosomes, and spindle orientation checkpoints, indicating regulation of chromosome segregation during mitosis/meiosis. While a couple terms (e.g., P granule assembly) are less directly tied, the dominant theme is chromosome handling and checkpoint control during division.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090219","count":1},{"id":"GO:0006470","count":1},{"id":"GO:0031578","count":1},{"id":"GO:0090005","count":1},{"id":"GO:0007165","count":1}]},{"hash":"1581983507297142741","title":"Vacuolar trafficking and ion homeostasis","description":"The terms show a clear focus on vacuole-related biology (protein targeting to vacuole, vacuolar acidification, vacuole organization) along with ion transport and proton-driven processes (sodium and copper ion transport, proton transmembrane transport, proton motive force-driven ATP synthesis). This combination points to a coherent role in vacuolar function and maintaining ion balance and energy across membranes, rather than unrelated processes.  ","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":2},{"id":"GO:0015991","count":1},{"id":"GO:0007035","count":1},{"id":"GO:0006814","count":1},{"id":"GO:0007033","count":1}]},{"hash":"485141238919330432","title":"Unknown","description":"The top GO terms are scattered across neural signaling, hormone biosynthesis, ion transport, immune regulation, and pain perception, with no common function or pathway tying the four proteins together. There are no edges or shared enriched terms to define a cohesive cluster, so a specific functional label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900454","count":1},{"id":"GO:0034651","count":1},{"id":"GO:0021759","count":1},{"id":"GO:0035024","count":1},{"id":"GO:0086047","count":1}]},{"hash":"367303780550327278","title":"Epidermal proliferation control and apoptosis","description":"The GO terms cluster around negative regulation of keratinocyte proliferation, regulation of epidermal cell division, and keratinization, complemented by intrinsic apoptotic signaling in response to DNA damage and cytochrome c release. This suggests a group of proteins involved in restraining epidermal cell growth/differentiation and mediating stress-induced apoptosis, with additional signals related to cellular stress responses (e.g., Golgi reassembly, kinase activity regulation). Overall, the theme points to epidermal growth arrest coupled with DNA-damage\u2013driven apoptosis; the connection is plausible but based on a small set of terms, so the confidence is Medium.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010839","count":2},{"id":"GO:0001836","count":1},{"id":"GO:0090168","count":1},{"id":"GO:0008630","count":1},{"id":"GO:0071901","count":1}]},{"hash":"966011731616997057","title":"Vascular and cardiac development signaling","description":"This cluster shows strong representation of angiogenesis (GO:0001525), VEGF production (GO:0010573), and heart trabecula formation (GO:0060347), suggesting a cohesive theme around vascular and cardiac development and associated signaling pathways (PKC signaling, inositol phosphate biosynthesis). A single electron transport chain term appears ancillary rather than central to the main function. Overall, the label captures the core developmental context of the proteins.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0051867","count":1},{"id":"GO:0060133","count":1},{"id":"GO:0045176","count":1},{"id":"GO:0090179","count":1}]},{"hash":"689677045609846965","title":"Signaling and Transcription Regulation","description":"A core theme among the GO terms is regulatory control, including negative regulation of ERK signaling, ubiquitination, regulation of transcription by RNA polymerase II, and chromatin-related regulation, with additional terms touching developmental and cell-adhesion processes. This suggests the proteins collectively participate in broader regulatory roles rather than a single tightly defined pathway, justifying a label centered on signaling and transcription regulation.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":3},{"id":"GO:0070534","count":2},{"id":"GO:0046642","count":2},{"id":"GO:0060449","count":2},{"id":"GO:0097118","count":2}]},{"hash":"1512856006420254502","title":"Unknown","description":"There are no shared GO terms or interactions (no edges, no topology) to anchor a functional label, so the cluster cannot be confidently characterized.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"303830955466400793","title":"Chromatin modification and heterochromatin regulation","description":"This cluster\u2019s terms cluster around histone modifications (e.g., H3K4/H3K36 demethylation, histone hydroxylation) and heterochromatin-related processes (RITS complex localization, negative regulation of rDNA heterochromatin formation), pointing to chromatin state control and transcriptional silencing as the shared theme, despite several obsolete GO terms. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036138","count":1},{"id":"GO:0034630","count":1},{"id":"GO:0040010","count":1},{"id":"GO:0061188","count":1},{"id":"GO:0034720","count":1}]},{"hash":"1282685560159428338","title":"Acetylation-Linked PTMs","description":"This cluster centers on acetylation-related processes: N-terminal serine/methionine acetylation, peptidyl-lysine N6-acetylation, and spermidine acetylation are all acetylation events; melatonin biosynthesis involves an acetyltransferase step, and subtelomeric heterochromatin formation relates to histone acetylation controlling chromatin state. Additional terms like glucosamine metabolism and polyamine turnover can connect to acetyl-CoA\u2013dependent pathways, tying these diverse functions together under a common acetylation theme.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0019491","count":4},{"id":"GO:0030187","count":4},{"id":"GO:0006348","count":4},{"id":"GO:0017198","count":4}]},{"hash":"2134352130930956764","title":"Prostaglandin Biosynthesis and Inflammatory Response","description":"The top GO terms are dominated by prostaglandin biosynthesis, with supporting terms for inflammatory and detoxification responses (e.g., response to lipopolysaccharide, cellular oxidant detoxification, toxin catabolic process), suggesting a cluster tied to lipid mediator production and associated stress/inflammatory pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":2},{"id":"GO:0090503","count":1},{"id":"GO:0006308","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0033591","count":1}]},{"hash":"371162692966583597","title":"Organ development and tissue differentiation","description":"Interpretation: The top GO terms largely point to tissue- and organ-specific differentiation (trachea cartilage development, ventricular cardiac muscle cell differentiation, epithelial cell differentiation in prostate gland) and transcriptional control (DNA-templated transcription). A few terms involve immune signaling, which may reflect broader regulatory connections, but the dominant theme is developmental differentiation across tissues.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060534","count":4},{"id":"GO:0055012","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0071222","count":3},{"id":"GO:0035264","count":3}]},{"hash":"319359785323536845","title":"Organelle Contact Sites and Neuronal Plasticity","description":"The terms cluster around mitochondria-ER interactions (mitochondrion inheritance, ER-mitochondria tethering, reticulophagy) and vesicle trafficking (secretory pathway, ER-to-Golgi transport), coupled with actin remodeling and synapse plasticity, plus neuronal development hints. This suggests a cohesive theme of organelle interface dynamics and trafficking underpinning neuronal connectivity and plasticity.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":3},{"id":"GO:0061709","count":2},{"id":"GO:0045054","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0043316","count":2}]},{"hash":"999937412833868682","title":"Heart and retina development","description":"These proteins are linked by developmental GO terms, notably heart development and ventricular cardiac muscle morphogenesis, with retinal cone cell development also represented. This suggests a general developmental theme spanning cardiovascular and ocular development, rather than a single cohesive pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046549","count":3},{"id":"GO:1903799","count":3},{"id":"GO:0055010","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0071222","count":2}]},{"hash":"1172789213323658743","title":"Meiotic Oocyte Maturation and Spindle Assembly","description":"This cluster is dominated by terms related to female meiosis and oocyte maturation, including oocyte maturation itself, spindle assembly in female meiosis I, and microtubule polymerization, as well as SCF-proteasomal ubiquitin-dependent protein degradation that drives meiotic progression. While a couple of terms touch on broader developmental processes, the strongest and most coherent signal is meiotic progression in oocytes, justifying a focused label on oocyte maturation and spindle dynamics.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0021678","count":2},{"id":"GO:0021993","count":2},{"id":"GO:0070544","count":2}]},{"hash":"97510113298470642","title":"Histone modification and epigenetic regulation","description":"This cluster is dominated by terms related to histone modifications (H3K4/H3K27 methylation and demethylation) and regulation of DNA methylation, pointing to chromatin-based control of gene expression as the core function. Additional terms reference apoptotic signaling and developmental processes (spermatid differentiation, thymus morphogenesis), but the most consistent signal is epigenetic regulation via histone marks. Note that several GO terms are obsolete, but the theme remains interpretable. ","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097190","count":1},{"id":"GO:0034720","count":1},{"id":"GO:0010216","count":1},{"id":"GO:0007289","count":1},{"id":"GO:1904388","count":1}]},{"hash":"114207149409138310","title":"Ubiquitin and SUMO modification in development","description":"This cluster\u2019s GO terms center on ubiquitination (K48 and K63) and sumoylation, plus developmental processes like blastocyst formation and axis elongation. This suggests the proteins participate in post-translational modification pathways that regulate embryogenesis and morphogenesis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070534","count":1},{"id":"GO:0051026","count":1},{"id":"GO:0070936","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0060028","count":1}]},{"hash":"1275121154520067586","title":"Cytoskeletal dynamics and cell polarity","description":"The terms cluster around cytoskeletal organization and cell shape regulation (sarcomere organization, microtubule plus-end localization, plasma membrane organization, establishment/maintenance of cell polarity), with a note on nucleokinesis and migration. Although some terms involve membrane receptor signaling and platelet formation, the dominant theme is cytoskeleton-driven polarity and movement. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070493","count":1},{"id":"GO:2000273","count":1},{"id":"GO:0021817","count":1},{"id":"GO:1903715","count":1},{"id":"GO:0045214","count":1}]},{"hash":"2044811059407884213","title":"Unknown","description":"There are no GO terms or shared functional signals provided for this cluster (Edges 0, Triangles 0, Top Terms empty), so there's no evident common pathway or role linking the four proteins. Without GO terms to tie them together, the appropriate label is Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1672036514940448101","title":"Unknown","description":"This cluster lists GO terms from very diverse processes (DNA recombination, angiogenesis, calcium transport, B cell differentiation, multiple signaling pathways, and neuronal transmission), with no single cohesive function tying them together, so a confident, representative label isn\u2019t feasible.","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0001525","count":1},{"id":"GO:0006816","count":1},{"id":"GO:0002316","count":1},{"id":"GO:0035477","count":1}]},{"hash":"1744258307984880733","title":"Neuronal development and signaling with actin dynamics","description":"The dominant terms are neuronal development, neurotrophin receptor signaling, and receptor clustering, plus regulation of actin filament binding, which together point to neuronal differentiation and cytoskeletal signaling. Some terms like lipopolysaccharide response and angiogenesis appear less central, so the core theme is neuron-specific signaling and actin dynamics.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048666","count":4},{"id":"GO:0032435","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0042517","count":3}]},{"hash":"1070997537564847928","title":"Flavonoid and lignin biosynthesis","description":"The top GO terms strongly point to plant secondary metabolism, with specific flavonoid biosynthesis (kaempferol O-glucoside and cyanidin 3-O-glucoside) and lignin metabolic processes dominating the set, suggesting a phenylpropanoid pathway\u2013related cluster. Other biosynthetic processes appear as general context but do not override the flavonoid/lignin signal.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009808","count":1},{"id":"GO:0033485","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0070980","count":1},{"id":"GO:0008360","count":1}]},{"hash":"2029900920688183880","title":"RNA processing and translation regulation","description":"The dominant terms point to RNA maturation/splicing (RNA folding, SSU-rRNA maturation, Group I intron splicing, RNA splicing regulation) and translation control (translation, regulation of translational fidelity). A few unrelated GO terms appear infrequently, likely noise.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034337","count":1},{"id":"GO:0033120","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0000372","count":1},{"id":"GO:0046677","count":1}]},{"hash":"846576382741318044","title":"Nematode development and cortical actin regulation","description":"The GO terms converge on nematode-specific development processes (molting, pharyngeal pumping) and cytoskeletal/cortical organization (actin cortex localization, medial cortex localization), with accompanying signaling (kinase activation, cell cycle regulation). While not tied to a single pathway, the shared theme is nematode morphogenesis linked to cortical actin dynamics, suggesting this cluster centers on development with cytoskeletal regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048012","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0043050","count":2},{"id":"GO:0060583","count":1},{"id":"GO:0051291","count":1}]},{"hash":"314956236786935921","title":"Neurite outgrowth and signaling","description":"The cluster is dominated by terms tied to neuronal development and signaling, such as axonogenesis, neurotrophin/TRK receptor signaling, receptor clustering, and regulation of actin dynamics, all suggesting growth and communication in neural contexts. While there are some immune/stress-related terms (response to toxic substance, LPS), they are less central to the main theme, making neuronal growth and receptor-mediated signaling the most coherent interpretation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009636","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0042517","count":3},{"id":"GO:2001275","count":3}]},{"hash":"1602263128165840456","title":"Tissue remodeling and ECM turnover","description":"The top terms converge on extracellular matrix remodeling and bone/developmental processes (intramembranous ossification, bone resorption, collagen catabolic process, basement membrane disassembly), with related morphogenetic events like lung branching and decidualization. Some terms are older/obsolete annotations, but the shared theme is remodeling of ECM and tissues across contexts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":2},{"id":"GO:0045453","count":2},{"id":"GO:0051603","count":2},{"id":"GO:0001913","count":2},{"id":"GO:0030574","count":2}]},{"hash":"127755480540414823","title":"Apoptosis and oxidative stress response","description":"This cluster shows strong signals for apoptotic process along with responses to oxidative and DNA-damaging stresses (hydrogen peroxide, UV-A, gamma radiation), suggesting a thematic link to stress-induced cell fate decisions. Some terms like muscle contraction or estradiol response are more peripheral, but the dominant pattern centers on apoptosis and oxidative stress. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:2000378","count":1},{"id":"GO:0042542","count":1},{"id":"GO:0006936","count":1},{"id":"GO:0070141","count":1}]},{"hash":"44388900882186193","title":"Mitochondrial cristae formation","description":"Four proteins map to a mitochondrion-related function, with the top GO term being cristae formation (GO:0042407). This suggests the cluster\u2019s shared role is in the assembly or maintenance of mitochondrial cristae, despite minimal connectivity or additional terms. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042407","count":1}]},{"hash":"1658006885570360411","title":"Organelle Membrane Targeting","description":"The top GO terms cluster around targeting and insertion of proteins to mitochondrial and ER membranes, as well as intralumenal vesicle formation and related trafficking processes, suggesting a membrane-targeting/trafficking theme within the cluster. The small size and inclusion of some obsolete terms temper confidence, but membrane association is the clearest common thread.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072321","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0045039","count":1},{"id":"GO:0070676","count":1},{"id":"GO:0039702","count":1}]},{"hash":"1863883161406922160","title":"Unknown","description":"The GO terms listed are highly diverse (circadian rhythm, starch catabolic process, nitrogen response, pollen hydration, nail development, etc.) and there is no clear shared function or pathway linking these four proteins. With no edges and only singleton terms across disparate processes, a coherent label cannot be inferred.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":1},{"id":"GO:0007623","count":1},{"id":"GO:0005983","count":1},{"id":"GO:0043562","count":1},{"id":"GO:0007165","count":1}]},{"hash":"2038673198243712811","title":"Plant Cell Wall Polysaccharide Biosynthesis and Glycosylation","description":"Top GO terms point to biosynthesis of plant cell wall polysaccharides (homogalacturonan, mucilage, mannans, galactose metabolism) and plant-type secondary cell wall biogenesis with cell wall organization, complemented by glycosylation-related terms, suggesting a cohesive theme of wall polysaccharide construction and glycoprotein modification.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010289","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0010192","count":2},{"id":"GO:0005978","count":2},{"id":"GO:0046354","count":2}]},{"hash":"1347024688332328402","title":"Unknown","description":"There are no GO terms provided for this cluster, and the network has no edges or triangles. With only a single protein re-added by ReCIPE and no shared annotations, there is no clear theme tying the proteins together. Therefore, it is best labeled Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1948806042416986196","title":"Diverse Transmembrane Transporters","description":"The top GO terms indicate multiple transmembrane transport activities across a wide range of substrates, including sugars (galactose, arabinose), ions (sodium, phosphate), vitamins, nitrates, xenobiotics, and even neurotransmitter loading into synaptic vesicles. This pattern points to a cluster of membrane transporter proteins with broad or varied substrate specificity rather than a single substrate type.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0015751","count":1},{"id":"GO:0015706","count":1}]},{"hash":"1003278313322267389","title":"Nuclear transport and chromatin tethering","description":"The top GO terms cluster around nucleocytoplasmic transport and nuclear pore function (nuclear pore organization; ribosomal subunit export; mRNA export; NLS-bearing protein import) together with chromatin and telomere organization at the nuclear periphery (tethering of RNA Pol II genes and telomeres). This combination points to proteins involved in nuclear transport and nuclear architecture, so a label like \u201cNuclear transport and chromatin tethering\u201d captures the shared function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035080","count":3},{"id":"GO:0006409","count":3},{"id":"GO:0035392","count":3},{"id":"GO:0006999","count":3},{"id":"GO:0000973","count":3}]},{"hash":"252358155058101114","title":"Ubiquitination-driven proteostasis and chromatin regulation","description":"These proteins cluster around ubiquitin-related processes, including K63-linked ubiquitination, histone ubiquitination, and neddylation, with a broader link to proteasome-dependent quality control. Additional terms point to chromatin regulation and cell cycle aspects (subtelomeric heterochromatin formation, mitotic spindle elongation). Collectively, the theme is ubiquitin-centric modification and proteostasis influencing chromatin and division. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043951","count":3},{"id":"GO:0070534","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0009737","count":3},{"id":"GO:0045116","count":3}]},{"hash":"225770273085809133","title":"Unknown","description":"No GO terms are listed here to infer a shared biological function among NP_ proteins; with only connectivity data and no functional signals, a meaningful cluster name cannot be assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"926522288743077955","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":2},{"id":"GO:0046784","count":1},{"id":"GO:0002188","count":1},{"id":"GO:1901976","count":1},{"id":"GO:0035264","count":1}]},{"hash":"645083938078539107","title":"Unknown","description":"There are no GO terms provided for this cluster, and with only 3 proteins and 2 edges, there is no clear functional theme linking them. Without top terms to guide labeling, a specific, representative label cannot be determined.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"357575768399600092","title":"Nuclear processes and genome regulation","description":"The GO terms show a common theme around nucleus-centric functions: transcription regulation, DNA replication and chromatin assembly, nuclear import and mRNA transport, mitotic nuclear events, and nuclear receptor\u2013related signaling. While there are a few broader or peripheral terms (e.g., endothelial proliferation), the core cluster centers on nuclear regulation and genome maintenance, supporting a cohesive label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000324","count":2},{"id":"GO:0001938","count":1},{"id":"GO:0006275","count":1},{"id":"GO:0045945","count":1},{"id":"GO:0006335","count":1}]},{"hash":"325176397532016432","title":"Protein post-translational modifications","description":"Enrichment centers on multiple amino acid modifications (arginine hydroxylation, lysine methylation/dimethylation, N-terminal serine dimethylation) indicating a PTM-focused cluster. Additional terms include mRNA capping and biosynthetic/stress-related processes, suggesting some breadth beyond PTMs but with covalent protein modification as the core signal.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030961","count":2},{"id":"GO:0018027","count":2},{"id":"GO:0006744","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0035572","count":2}]},{"hash":"1326602026170720360","title":"Glycan biosynthesis and cell-surface adhesion","description":"The top GO terms cluster around glycosylation and glycan biosynthesis (arabinogalactan protein metabolism, poly-N-acetyllactosamine, Lewis a epitope, O-linked glycosylation) and related cell-surface/ECM processes (cell adhesion, polarity maintenance). This suggests these proteins participate in glycan modification on cell surfaces that influence adhesion and developmental interactions, despite species-specific contexts. Confidence: Medium","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042248","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0007299","count":2},{"id":"GO:0048354","count":2},{"id":"GO:0010405","count":2}]},{"hash":"2247818759931011845","title":"Axonogenesis and Neurotrophin Signaling","description":"This cluster is strongly annotated with axonogenesis and neurotrophin TRK receptor signaling (GO:0007409 and GO:2001275), plus related receptor clustering and actin cytoskeleton regulation, suggesting a shared role in neurite outgrowth and neuronal signaling. Other terms such as angiogenesis and cellular response to lipopolysaccharide appear, but the core signal aligns with neuronal growth pathways rather than immune or vascular processes.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0042517","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0043113","count":3}]},{"hash":"814443396432631568","title":"Dopamine/Catecholamine Metabolism","description":"The top GO terms are dominated by dopamine- and catecholamine-related metabolic processes (dopamine catabolic process, catecholamine metabolic process, negative regulation of dopamine metabolic process), indicating a cohesive theme around dopamine metabolism. Some unrelated terms appear (e.g., lignin, coumarin biosynthesis, auditory receptor development), but the strongest signal points to catecholamine/dopamine metabolism as the cluster\u2019s functional hallmark.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042135","count":2},{"id":"GO:0050668","count":2},{"id":"GO:0009809","count":2},{"id":"GO:0006584","count":2},{"id":"GO:0060117","count":2}]},{"hash":"1658232034070446682","title":"Unknown","description":"The top GO terms span chromatin/chromosome regulation, transcription regulation, post-translational modifications, and several diverse developmental processes, with many obsolete annotations. There is no single coherent theme linking these terms to a specific, shared function for the cluster, and the tiny size with no edges suggests the cluster may be noise or mixed annotations. Therefore, a specific functional label cannot be reliably assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905524","count":1},{"id":"GO:0031452","count":1},{"id":"GO:0006990","count":1},{"id":"GO:0002574","count":1},{"id":"GO:0010835","count":1}]},{"hash":"1364026396229922523","title":"Unknown","description":"The top GO terms span diverse developmental and immune processes (ureter morphogenesis, nephron tubule formation, neural crest migration, lens/photoreceptor development) and T-helper activation, with no clear overarching function. With no edges and highly scattered terms, there is no single cohesive theme to label this cluster reliably.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072197","count":2},{"id":"GO:0007140","count":2},{"id":"GO:0046533","count":2},{"id":"GO:0035711","count":2},{"id":"GO:0071504","count":2}]},{"hash":"1310257155177469970","title":"Nuclear mRNA Splicing and Spliceosome Assembly","description":"Dominant GO terms are about mRNA splicing and spliceosome assembly (GO:0045292, GO:0000245), plus related nuclear RNA processing steps (e.g., maturation of SSU-rRNA, deadenylation-dependent decapping, and nuclear import). This suggests the cluster represents nuclear RNA maturation/splicing machinery. Some terms also touch on chromatin-related processes, but the strongest signal is RNA splicing.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0070317","count":2},{"id":"GO:0051170","count":2},{"id":"GO:0030490","count":2},{"id":"GO:0000290","count":2}]},{"hash":"1080299464674926985","title":"Synaptic Vesicle Regulation and APP Metabolism","description":"Top GO terms cluster around neuronal synapse biology, including positive regulation of protein localization to the synapse, synaptic vesicle clustering and its regulation, receptor internalization, and learning. The amyloid precursor protein metabolic process reinforces a neuronal/synaptic context, while retina development suggests broader neural development involvement. Overall, the proteins appear linked by synaptic function with APP metabolism as a notable associated pathway; a few peripheral terms exist but do not obscure the core theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902474","count":1},{"id":"GO:0042982","count":1},{"id":"GO:0060041","count":1},{"id":"GO:0015705","count":1},{"id":"GO:0042136","count":1}]},{"hash":"1234366581789700982","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0009307","count":2},{"id":"GO:0000472","count":2},{"id":"GO:1990416","count":2}]},{"hash":"1359319070136692567","title":"Organogenesis and Embryonic Morphogenesis","description":"The top GO terms center on morphogenesis and organ development across multiple tissues (embryonic development, cardiac and muscle morphogenesis, eye development, thymus epithelium morphogenesis, circulatory system development, etc.), suggesting a coherent theme of organogenesis rather than a single pathway. The absence of network edges does not diminish this functional coherence, as the annotation-driven clustering captures shared developmental roles.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060528","count":2},{"id":"GO:0001547","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0055010","count":2},{"id":"GO:0048048","count":2}]},{"hash":"23608780613585896","title":"Ubiquitin-Dependent Proteolysis and Cell Cycle Regulation","description":"The top GO terms cluster around ubiquitin-mediated protein degradation (including K11-linked ubiquitination and histone H2A monoubiquitination) and key cell cycle transitions (G1/S, G2/M, and metaphase/anaphase). While there are some development-related morphogenesis terms, the dominant theme is ubiquitin signaling controlling protein turnover and cell-cycle progression, suggesting this cluster centers on ubiquitin-dependent regulation of the cell cycle.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0000082","count":1},{"id":"GO:0072576","count":1},{"id":"GO:0008283","count":1},{"id":"GO:0035518","count":1}]},{"hash":"1681042588348423151","title":"Unknown","description":"The GO terms are highly diverse: several distinct metabolic pathways (homocysteine, serine, carbohydrate, fatty acid metabolism), ion transport, nuclear import, retina development, and immune cell proliferation. There is no single shared function tying these proteins together, so a cohesive, specific label isn\u2019t evident.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043418","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0046651","count":2},{"id":"GO:1903830","count":2}]},{"hash":"1708887501425476073","title":"Unknown","description":"The GO terms span mitochondrial respiration, vesicle formation/disassembly, peroxisomal import, chaperone-mediated assembly, stress granule dynamics, and glycosylation, with no single common function connecting the proteins.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034551","count":1},{"id":"GO:0070676","count":1},{"id":"GO:0035494","count":1},{"id":"GO:0016562","count":1},{"id":"GO:1903715","count":1}]},{"hash":"540314232462515849","title":"Mitochondrial electron transport","description":"The only enriched GO term is GO:0006120, \u201cmitochondrial electron transport, NADH to ubiquinone,\u201d indicating involvement in the oxidative phosphorylation pathway. With three proteins and no interactions, they likely share a mitochondrial respiration function centered on the NADH dehydrogenase-to-ubiquinone step.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":1}]},{"hash":"1777784134417458423","title":"Neuronal signaling and ion transport","description":"The top GO terms point to neural activity and synaptic regulation (neuronal action potential, regulation of long-term synaptic depression, globus pallidus development, neural development signals) together with ionic processes (potassium ion export, membrane repolarization, magnesium ion response) and related cardiac conduction terms, suggesting a cluster centered on neuronal excitability and ion-channel\u2013mediated signaling with some overlap into cardiac electrical activity.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900454","count":2},{"id":"GO:0044335","count":2},{"id":"GO:0071286","count":2},{"id":"GO:0021759","count":2},{"id":"GO:0035024","count":2}]},{"hash":"790149690782527477","title":"Chitin-based cuticle development and ecdysis","description":"The strongest signals are chitin-based cuticle development, chitin catabolic process, and ecdysis, all reflecting arthropod exoskeleton formation and molting. Other terms (interleukin responses, cartilage/lung development) are only single entries and likely incidental. So the cluster most plausibly tags chitinous cuticle biology.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0070741","count":1},{"id":"GO:0030324","count":1}]},{"hash":"1328604751943544384","title":"Cardiac and Vascular Development and ECM Remodeling","description":"The GO terms point to heart and valve morphogenesis (cardiac right ventricle and pulmonary valve development), endothelial adhesion, and mesenchymal/smooth muscle proliferation, alongside extracellular matrix processes like hyaluronan biosynthesis and receptor clustering. This suggests a coordinated program of cardiovascular development with ECM remodeling and cell\u2013cell signaling. Vitamin D response and prostaglandin biosynthesis may modulate these processes, but the core theme remains heart/vasculature development and ECM dynamics.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0071603","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0048661","count":1},{"id":"GO:0003215","count":1}]},{"hash":"1096402654130148509","title":"Sugar Catabolism (Multi-sugar Pathways)","description":"The top GO terms are dominated by sugar- and carbohydrate-catabolic processes (L-arabinose, L-fucose, D-xylose, rhamnose, glycerol, and related pathways), plus a carbohydrate phosphorylation term, pointing to a shared function in carbohydrate degradation and utilization. Some terms (nucleotidyl decapping and quorum sensing) are less related and may reflect noise, but the strongest signal supports a sugar-catabolism theme for these proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031087","count":1},{"id":"GO:0046496","count":1},{"id":"GO:0019569","count":1},{"id":"GO:0042355","count":1},{"id":"GO:0009372","count":1}]},{"hash":"1839920761008171900","title":"Viral integration and latency","description":"The top GO terms point to viral entry into the host nucleus, establishment of integrated proviral latency, and DNA integration, with related host\u2013virus interactions such as apoptosis activation and DNA repair/recombination. This suggests a theme around viral genome integration and latency rather than a single host cellular pathway, so this concise label reflects the central function of the cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":1},{"id":"GO:0044179","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0006284","count":1},{"id":"GO:0006310","count":1}]},{"hash":"1990669374386609204","title":"Amino acid transport across membranes","description":"These proteins are linked to transmembrane transport and import of several amino acids (glutamate, threonine, serine, D-aspartate), with a related note on GABA biosynthesis. Together, the GO terms indicate a common theme of amino acid uptake across the plasma membrane, suggesting transporter or importer roles. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055085","count":1},{"id":"GO:0051938","count":1},{"id":"GO:0015826","count":1},{"id":"GO:0009449","count":1},{"id":"GO:0070779","count":1}]},{"hash":"362310693575485588","title":"Unknown","description":"The top GO terms span diverse processes (drug/xenobiotic response, calcium signaling, meiotic DNA repair, transcription termination, development) with no single dominant function. Coupled with no observed edges and only a few annotations, there is no cohesive theme to assign a specific label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0005513","count":1},{"id":"GO:0060316","count":1},{"id":"GO:0010780","count":1}]},{"hash":"185972313359231192","title":"Neuronal synapse and microtubule assembly","description":"Most terms point to neuronal synapse formation and function (dendritic spine development, synaptic vesicle budding) and cytoskeletal organization (tubulin complex assembly). Some terms appear as noise (umami taste, kidney development, forskolin response), but the core theme is neuronal/synaptic biology with microtubule dynamics. Confidence: Medium","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007021","count":2},{"id":"GO:0045176","count":1},{"id":"GO:0050917","count":1},{"id":"GO:1904322","count":1},{"id":"GO:0060999","count":1}]},{"hash":"1872754388987025940","title":"Developmental signaling and organogenesis with cytokine production","description":"These proteins are linked to broad developmental processes (nervous system development, heart development, angiogenesis, multicellular organism development, salivary gland boundary specification) and to signaling pathways (ERK cascade, STAT tyrosine phosphorylation). The presence of dendritic and mast cell cytokine production terms suggests additional roles in immune signaling. Although the cluster lacks interaction edges, the shared GO annotations point to a coherent theme of developmental signaling that can also engage immune cytokine activity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007507","count":3}]},{"hash":"285348012257370003","title":"Unknown","description":"The terms span coagulation signaling, peroxisome autophagy, carbohydrate response, endothelial apoptosis, PKC regulation, Th17 immune signaling, IGF receptor signaling, imaginal disc morphogenesis, focal adhesion dynamics, and Rho signaling, with no single shared function or pathway. Zero edges and only disparate, single-term associations suggest no coherent theme to label coherently.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070493","count":1},{"id":"GO:0030242","count":1},{"id":"GO:0071322","count":1},{"id":"GO:2000353","count":1},{"id":"GO:0090038","count":1}]},{"hash":"1363382461534878970","title":"Unknown","description":"The GO terms span very diverse processes, including skin differentiation, CNS myelin maintenance, fungal sphingolipid and sterol metabolism, fatty acid biosynthesis, nitrate/nitric oxide metabolism, and mitochondrial inheritance. There is no clear single functional theme connecting these proteins, suggesting the cluster is heterogeneous rather than representing one cohesive biological function.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001949","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0032443","count":3},{"id":"GO:0006636","count":3}]},{"hash":"1485154223706319775","title":"Membrane transport and secretion processes","description":"The top GO terms cluster around membrane-related activities: various transmembrane transport processes (xenobiotic, cobalt ion), protein secretion mechanisms, and pathway terms related to barrier biosynthesis (cutin, suberin) and even plant vascular development. This suggests a cohesive theme centered on membrane transport and secretory pathways with roles in barrier formation and compound handling, despite some diversity in specific terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0010222","count":1},{"id":"GO:0080051","count":1},{"id":"GO:0030253","count":1}]},{"hash":"556322162574108276","title":"Mitotic spindle assembly and chromatin organization","description":"The terms cluster around microtubule-based mitosis (spindle elongation, spindle localization, microtubule anchoring) and chromatin assembly during DNA replication, plus regulation of DNA replication and Pol III transcription, suggesting a cohesive theme of cell division mechanics and chromatin organization. Some peripheral terms (endothelial proliferation, hemocyte migration) are less central to this core, but do not override the dominant mitotic/chromatin signal.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001938","count":1},{"id":"GO:0035099","count":1},{"id":"GO:0006275","count":1},{"id":"GO:0042176","count":1},{"id":"GO:0051231","count":1}]},{"hash":"570659175462196570","title":"Sprouting Angiogenesis and Endothelial Migration Signaling","description":"The terms point to angiogenesis and specifically sprouting processes, including regulation of endothelial proliferation and cell migration in sprouting contexts, along with cytoskeletal remodeling (stress fibers), Rho and MAPK signaling, and Notch involvement\u2014all indicative of coordinated signaling driving sprouting angiogenesis and endothelial cell movement.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0043149","count":1},{"id":"GO:0035023","count":1},{"id":"GO:0033138","count":1}]},{"hash":"1685308195329518795","title":"Unknown","description":"There are no GO terms listed for this cluster and no edges or term frequencies to anchor a shared function, so a meaningful label cannot be inferred. Without functional clues, the safest label is Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2078117449940782682","title":"Plant cell wall cellulose biosynthesis and regulation","description":"Based on GO terms, the proteins are linked to plant-type cell wall cellulose biosynthesis and its regulation, suggesting the cluster represents components involved in synthesizing cellulose for the plant cell wall and regulating that process. The two GO terms reinforce a cohesive theme of cellulose production and its control, despite only three proteins and no reported interactions.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001009","count":1},{"id":"GO:0052324","count":1}]},{"hash":"1346210157268739459","title":"DNA Repair and Stress Response","description":"This cluster's GO terms center on DNA repair pathways (base-excision repair, nucleotide-excision repair) and DNA recombination, suggesting a core function in genome maintenance. Several \"response to ...\" terms (cadmium, ethanol, estradiol, light, folic acid) indicate broader environmental and metabolic stress signaling that could modulate these repair processes. The overall theme is DNA damage response with secondary stress signaling, despite low connectivity among the proteins.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006284","count":1},{"id":"GO:0071276","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0045471","count":1},{"id":"GO:0006289","count":1}]},{"hash":"221282349402044200","title":"Cerebellar development and Bergmann glia differentiation","description":"The top GO terms point to cerebellar development themes: cerebellar cortex formation and Bergmann glial cell differentiation, plus regulation of axon regeneration, suggesting a cluster centered on cerebellar neurodevelopment and glial involvement. Other terms (insulin signaling, cell cycle regulation) appear less directly connected and may reflect broader signaling context or annotation noise. This makes the label plausible and reasonably representative, though not definitive. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048679","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0060020","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1152823596951892363","title":"Mitochondrial TCA Cycle and Electron Transport","description":"The cluster is dominated by mitochondrial energy metabolism terms: 2-oxoglutarate metabolic process, the tricarboxylic acid cycle, and mitochondrial electron transport (succinate to ubiquinone), along with lipoate and thiamine biosynthesis as cofactors for key dehydrogenases. This points to roles in ATP production and redox balance; a few other terms (lipopolysaccharide response, neuron projection extension) may reflect broader or context-specific functions and are less central to the core activity. Overall, the label reflects the primary shared function of these proteins.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006103","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0009106","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0034720","count":1}]},{"hash":"1100098954514099697","title":"Angiogenesis and vascular inflammatory signaling","description":"Based on GO terms dominated by angiogenesis, vascular remodeling (smooth muscle proliferation), BBB maintenance, TNF response, prostaglandin and FGF production, and NF-kappaB signaling, the cluster appears tied to endothelial/vascular development and inflammatory signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":1},{"id":"GO:0048661","count":1},{"id":"GO:0042346","count":1},{"id":"GO:0034612","count":1},{"id":"GO:0010042","count":1}]},{"hash":"574567360011104544","title":"Collagen Receptor Signaling in Cartilage","description":"This cluster is dominated by GO terms describing collagen-activated tyrosine kinase receptor signaling and cartilage formation processes, including cartilage condensation and angiogenesis, with supporting terms like receptor clustering and TRK receptor signaling. The pattern suggests proteins involved in collagen-responsive receptor tyrosine kinase signaling driving cartilage development and related cell signaling events.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038063","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0001525","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0042517","count":1}]},{"hash":"65831488725346028","title":"ECM Remodeling in Tissue Morphogenesis","description":"These proteins cluster around processes that remodel extracellular matrix and supporting structures during development and tissue remodeling: collagen catabolic process, basement membrane disassembly, bone resorption, and intramembranous ossification all reflect ECM turnover; lung branching morphogenesis and decidualization involve ECM and stromal remodeling. A couple terms (neuropeptide catabolic process, T cell cytotoxicity) appear as outliers, but the dominant signal is ECM remodeling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":1},{"id":"GO:0045453","count":1},{"id":"GO:0051603","count":1},{"id":"GO:0001913","count":1},{"id":"GO:0030574","count":1}]},{"hash":"1345603817116925197","title":"Diverse solute transmembrane transporters","description":"This cluster shows GO terms focused on transmembrane transport of a wide range of solutes (nitrate, arabinose, galactose, sodium ions, vitamins, xenobiotics) and even neurotransmitter loading into synaptic vesicles, suggesting these proteins function as membrane transporters with broad substrate scope rather than a single substrate class. The glycogen catabolic regulation term is less connected to the main theme. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045818","count":1},{"id":"GO:1900754","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0015751","count":1}]},{"hash":"1472310528034381059","title":"Embryonic Development and Patterning","description":"The GO terms point to a broad set of developmental processes across multiple tissues (retina, spinal cord, heart, teeth, ectoderm, kidney) and patterning events, suggesting a general role in embryogenesis rather than a narrow function. This makes \"Embryonic Development and Patterning\" a concise, representative label for the cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0023019","count":1},{"id":"GO:0035852","count":1},{"id":"GO:0060040","count":1},{"id":"GO:0001705","count":1},{"id":"GO:0072272","count":1}]},{"hash":"1971825244643819192","title":"Ubiquitin signaling and chromatin regulation","description":"This cluster is driven by ubiquitin-related processes (K63-linked ubiquitination, neddylation, histone ubiquitination) and chromatin-associated functions (subtelomeric heterochromatin formation, histone modifications) that align with control of the cell cycle and proteasome-mediated quality control, suggesting a theme of ubiquitin-mediated regulation of chromatin and cell division. Some terms (e.g., T cell receptor signaling, plant hormone response) appear as outliers, but the dominant signal supports the chromatin- and ubiquitin-centric theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000086","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0043951","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0006348","count":2}]},{"hash":"1893228256529147768","title":"Meiotic spindle assembly and oocyte maturation","description":"The cluster\u2019s terms converge on meiosis and oocyte development, including spindle assembly in female meiosis I, oocyte maturation, and SCF-mediated proteasomal degradation, which together reflect meiotic progression and cell-cycle control. Microtubule polymerization supports spindle formation, reinforcing this meiotic/oocyte-focused theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0021678","count":2},{"id":"GO:0021993","count":2},{"id":"GO:0070544","count":2}]},{"hash":"1404835959365486679","title":"Ubiquitin-Proteasome Degradation","description":"This cluster is dominated by GO terms related to ubiquitination and ubiquitin-dependent proteasomal protein catabolism (including specific linkages like K48, K11, K6) and SCF-dependent degradation, indicating a cohesive theme of tagging substrates for degradation via the proteasome. Peripheral terms such as viral processes and adaptive immune response appear incidental to the main ubiquitin\u2011mediated turnover function.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0070936","count":1},{"id":"GO:1902104","count":1},{"id":"GO:0070979","count":1}]},{"hash":"335215864538929532","title":"Nucleolar ribosome biogenesis and rRNA transcription","description":"The GO terms cluster around nucleolar functions: nucleologenesis; nucleolar large rRNA transcription by RNA Pol I; ribosome biogenesis; rRNA and tRNA transcription by RNA Pol I/II/III; and regulatory ncRNA-associated heterochromatin formation. Together these indicate a nucleolus-centered program of ribosome production and gene expression. Some meiosis-related terms appear but are not the primary theme here.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007283","count":2},{"id":"GO:0006366","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0042797","count":1}]},{"hash":"502028247989734396","title":"Plant cell wall biosynthesis and root hair development","description":"The top GO terms point to cell wall organization, RG-II pectin biosynthesis, and root hair cell development, which together suggest involvement in plant cell wall construction and root hair formation. The cluster thus likely represents proteins coordinating wall biosynthesis with root hair differentiation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":1},{"id":"GO:0010306","count":1},{"id":"GO:0080147","count":1}]},{"hash":"1989642746019171166","title":"Tissue and organ morphogenesis","description":"The GO terms point to development and morphogenesis across multiple tissues and organs (kidney tubules, lymph vessels, neuromast hair cells, lens, mucosal tissue, etc.), with no single shared pathway beyond general morphogenesis. This suggests the cluster reflects broad tissue/organ development rather than a specific process.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072237","count":1},{"id":"GO:0036303","count":1},{"id":"GO:0048903","count":1},{"id":"GO:0042994","count":1},{"id":"GO:0042403","count":1}]},{"hash":"1088926349209582780","title":"Neurotransmission and sensory processing","description":"These proteins cluster around neural signaling and sensory function: serotonin receptor signaling, dopamine secretion, synaptic transmission, sensory processing, and related behaviors (walking, taste aversion). Ion transport terms may reflect neuronal excitability, reinforcing a theme of neuronal communication and sensory-mens/motor behavior. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0043200","count":1},{"id":"GO:0050893","count":1},{"id":"GO:0007628","count":1}]},{"hash":"2288792983659824675","title":"Neural Signaling and Sensory Processing","description":"The GO terms emphasize neural signaling (serotonin receptor signaling, dopamine secretion, synaptic transmission), sensory processing, and related behaviors (taste aversion, walking, cochlea development). This suggests the proteins group around neural communication and sensory pathways.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0043200","count":1},{"id":"GO:0050893","count":1},{"id":"GO:0007628","count":1}]}]