{"hash":"919339664130081273","title":"Proteostasis and Immune Signaling Regulation","description":"This cluster shows enrichment for protein quality control and turnover (cellular response to misfolded protein, deubiquitination in ubiquitin-dependent protein catabolic process, regulation of ER to Golgi vesicle transport) alongside modulation of immune/inflammatory pathways (negative regulation of canonical NF-kappaB signaling, tolerance induction to LPS, negative regulation of leukocyte migration). While a couple of terms touch development, the strongest shared theme is coordination between proteostasis and inflammatory signaling in cellular contexts such as epithelia. ","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"members":[{"accession":"XP_001748610.1","go_terms":[]},{"accession":"XP_001747783.1","go_terms":[]},{"accession":"XP_001748428.1","go_terms":[]},{"accession":"XP_001746100.1","go_terms":["GO:0060628","GO:0060576"]},{"accession":"XP_001746378.1","go_terms":[]},{"accession":"XP_001743985.1","go_terms":[]},{"accession":"XP_001749970.1","go_terms":[]},{"accession":"XP_001749810.1","go_terms":["GO:0048745","GO:0006616","GO:0071243","GO:0060324","GO:0003016","GO:0071218","GO:0010761","GO:1902042","GO:0050869","GO:0060368","GO:2000349","GO:0071108","GO:0071947","GO:0048008","GO:0032495","GO:2000347","GO:0070936","GO:0002385","GO:0002686","GO:0048261","GO:0002677","GO:0070433","GO:0001944","GO:0043305","GO:0035871","GO:0032703","GO:0043124","GO:0031397","GO:0032720","GO:0070536","GO:0035214","GO:0048662","GO:0070301","GO:2000352","GO:0001922","GO:0002634","GO:0034140","GO:0034148","GO:0072573","GO:0070429","GO:1900165","GO:0032691","GO:1900235","GO:0032717","GO:0045736"]}],"graph":[["XP_001747783.1","XP_001748428.1",0.526],["XP_001747783.1","XP_001748610.1",0.746],["XP_001746100.1","XP_001749810.1",0.836],["XP_001746378.1","XP_001749810.1",0.731],["XP_001749810.1","XP_001748610.1",0.918],["XP_001749810.1","XP_001749970.1",0.695]],"all_go_terms":{"GO:0060576":1,"GO:0060628":1,"GO:0071243":1,"GO:0071218":1,"GO:0048662":1,"GO:0072573":1,"GO:0045736":1,"GO:0071947":1,"GO:0002686":1,"GO:0043124":1,"GO:0001944":1,"GO:0032691":1,"GO:0048261":1,"GO:0048008":1,"GO:0071108":1,"GO:0070429":1,"GO:0002634":1,"GO:0070936":1,"GO:0034140":1,"GO:1900165":1,"GO:0032495":1,"GO:1900235":1,"GO:2000352":1,"GO:0034148":1,"GO:0032720":1,"GO:0060324":1,"GO:0006616":1,"GO:0043305":1,"GO:1902042":1,"GO:0070536":1,"GO:0035214":1,"GO:0060368":1,"GO:0010761":1,"GO:0032703":1,"GO:0070433":1,"GO:0002677":1,"GO:2000347":1,"GO:0048745":1,"GO:0001922":1,"GO:2000349":1,"GO:0002385":1,"GO:0031397":1,"GO:0070301":1,"GO:0032717":1,"GO:0003016":1,"GO:0050869":1,"GO:0035871":1},"recipe_readded":[]}