{"hash":"2052519464238156875","title":"ER quality control and protein maturation","description":"The cluster is dominated by GO terms related to ER-associated processes: positive regulation of translation initiation in response to ER stress, post-translational protein targeting to membranes, misfolded protein transport, and (obsolete) ERAD pathways, all pointing to protein folding, processing, and degradation in the endoplasmic reticulum. Redox homeostasis also fits with the oxidative folding environment of the ER. A few terms like tRNA import into nucleus and DNA replication appear peripheral, but the core theme centers on protein maturation and quality control in the secretory pathway.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"members":[{"accession":"XP_001742295.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_001742421.1","go_terms":["GO:0033211","GO:1990522","GO:0019835","GO:0006882","GO:0061042","GO:1901223"]},{"accession":"XP_001742442.1","go_terms":[]},{"accession":"XP_001743262.1","go_terms":["GO:0042733","GO:0038016","GO:0046627","GO:0051898","GO:0046325"]},{"accession":"XP_001743354.1","go_terms":["GO:0015699","GO:0006849","GO:0015700","GO:0043251"]},{"accession":"XP_001750276.1","go_terms":[]},{"accession":"XP_001751032.1","go_terms":[]}],"graph":[["XP_001742295.1","XP_001742421.1",0.568],["XP_001742295.1","XP_001742442.1",0.775],["XP_001742295.1","XP_001743262.1",0.534],["XP_001742295.1","XP_001743354.1",0.924],["XP_001742295.1","XP_001750276.1",0.637],["XP_001742295.1","XP_001751032.1",0.556]],"all_go_terms":{"GO:0036494":1,"GO:0031204":1,"GO:0045454":1,"GO:0035719":1,"GO:0097428":1,"GO:0070843":1,"GO:0071374":1,"GO:0006260":1,"GO:1901621":1,"GO:0030433":1,"GO:0009408":1,"GO:0006452":1,"GO:0051259":1,"GO:0090084":1,"GO:0006986":1,"GO:1900035":1,"GO:0006469":1,"GO:0032781":1,"GO:0070389":1,"GO:0071630":1,"GO:0006626":1,"GO:0006458":1,"GO:0001707":1,"GO:0046825":1,"GO:0034975":1,"GO:1990522":1,"GO:0006882":1,"GO:0033211":1,"GO:0061042":1,"GO:1901223":1,"GO:0019835":1,"GO:0051898":1,"GO:0046627":1,"GO:0046325":1,"GO:0038016":1,"GO:0042733":1,"GO:0006849":1,"GO:0015699":1,"GO:0043251":1,"GO:0015700":1},"recipe_readded":[]}