{"hash":"1786913051891877459","title":"Cardiac Calcium Signaling and Electrical Coupling","description":"The top GO terms center on calcium handling (release of Ca2+ from the sarcoplasmic reticulum, RyR channel regulation, intracellular calcium signaling) and electrical signaling in heart and neurons (cardiac conduction, neuronal action potential propagation), suggesting a cohesive function in excitation-contraction coupling and calcium-mediated signaling. A couple of outliers (cell cycle, steroid receptor assembly) are peripheral to this core theme, but overall the cluster maps to calcium-dependent electrical signaling in excitable tissues.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"members":[{"accession":"XP_001749317.1","go_terms":["GO:0060347","GO:0046661","GO:0019227","GO:1903779","GO:0055010","GO:0006458","GO:1902991","GO:0032515","GO:0086064","GO:0051775","GO:0051301","GO:0032925","GO:0006939","GO:0000412","GO:1901710","GO:0042098","GO:0030850","GO:0035584","GO:0048680","GO:0007049","GO:0007183","GO:0030073","GO:0006463","GO:0014808","GO:0003007","GO:0060315","GO:0022417","GO:0042026","GO:1990000","GO:0061179","GO:0016925","GO:0061077","GO:0007179","GO:0042542","GO:0009749","GO:0033197"]},{"accession":"XP_001746243.1","go_terms":["GO:1902600","GO:0009060","GO:0006122"]},{"accession":"XP_001748316.1","go_terms":["GO:0001949","GO:0032286","GO:0006636","GO:0000001","GO:0032443","GO:0006675","GO:0042128","GO:0006809"]},{"accession":"XP_001749814.1","go_terms":["GO:0005975","GO:0016998","GO:0042742","GO:0009253","GO:0044659"]},{"accession":"XP_001748295.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091"]},{"accession":"XP_001745037.1","go_terms":["GO:0071391"]},{"accession":"XP_001748667.1","go_terms":["GO:0006572","GO:0006559","GO:0006357","GO:0006749","GO:0046677","GO:0042178","GO:0019243","GO:0055114"]},{"accession":"XP_001747781.1","go_terms":["GO:1903255","GO:0052704","GO:1903257","GO:1903253","GO:0052707"]}],"graph":[["XP_001745037.1","XP_001749814.1",0.95],["XP_001745037.1","XP_001748316.1",0.938],["XP_001748667.1","XP_001749814.1",0.825],["XP_001748316.1","XP_001749317.1",0.959],["XP_001749317.1","XP_001749814.1",0.564],["XP_001746243.1","XP_001749814.1",0.873],["XP_001747781.1","XP_001749814.1",0.537]],"all_go_terms":{"GO:0086064":1,"GO:0014808":1,"GO:0007049":1,"GO:0006463":1,"GO:0060315":1,"GO:0019227":1,"GO:0035584":1,"GO:0032925":1,"GO:0022417":1,"GO:0000412":1,"GO:0030073":1,"GO:0046661":1,"GO:0006939":1,"GO:0016925":1,"GO:0003007":1,"GO:1990000":1,"GO:0048680":1,"GO:0055010":1,"GO:0051301":1,"GO:1902991":1,"GO:1903779":1,"GO:1901710":1,"GO:0051775":1,"GO:0061077":1,"GO:0060347":1,"GO:0007179":1,"GO:0033197":1,"GO:0006458":1,"GO:0061179":1,"GO:0007183":1,"GO:0042098":1,"GO:0042542":1,"GO:0030850":1,"GO:0042026":1,"GO:0032515":1,"GO:0009749":1,"GO:1902600":1,"GO:0009060":1,"GO:0006122":1,"GO:0042128":1,"GO:0006809":1,"GO:0001949":1,"GO:0032286":1,"GO:0032443":1,"GO:0000001":1,"GO:0006675":1,"GO:0006636":1,"GO:0005975":1,"GO:0009253":1,"GO:0044659":1,"GO:0016998":1,"GO:0042742":1,"GO:1903206":1,"GO:0006662":1,"GO:0080058":1,"GO:1903026":1,"GO:0046826":1,"GO:0043388":1,"GO:0033158":1,"GO:0098869":1,"GO:0000122":1,"GO:0045454":1,"GO:0034976":1,"GO:0018401":1,"GO:0006351":1,"GO:0055114":2,"GO:0034975":1,"GO:0016032":1,"GO:0034599":1,"GO:0030091":1,"GO:0071391":1,"GO:0042178":1,"GO:0006572":1,"GO:0006559":1,"GO:0019243":1,"GO:0006357":1,"GO:0046677":1,"GO:0006749":1,"GO:1903253":1,"GO:1903257":1,"GO:0052704":1,"GO:0052707":1,"GO:1903255":1},"recipe_readded":[]}